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$74+ Cheap flights from Myrtle Beach (MYR) to Florida Keys

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/4. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — EYW
ago. 4 — ago. 111
lun. 8/4
lun. 8/11
1 adult, Economy
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Cheap flight deals from Myrtle Beach to Florida Keys

Keep the following information in mind while searching for Myrtle Beach to Florida Keys flight deals. Data was last updated julio 30, 2025.

Round-trip from

$171
(Mytrip)

One-way from

$74
(Cheapflightsfares)

Popular in

March

Cheapest in

October

Average price

$346
From Myrtle Beach Intl to Florida Keys
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One-way flight from Myrtle Beach Intl to Florida Keys
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Highest demand for flights based on searches. 13% potential increase in price ($51 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from Myrtle Beach to Florida Keys

Cheapest flights from Myrtle Beach to Florida Keys
Explore the most affordable flight options available from Myrtle Beach to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julio 30, 2025.

This Mytrip deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 8/216:50 amMYR - MIA
1 stop10h 26mSpirit Airlines
mié. 8/276:50 amMIA - MYR
1 stop5h 30mSpirit Airlines
Deal found 7/29$171
This CheapOair deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 8/299:35 amMYR - MIA
1 stop11h 10mMultiple Airlines
lun. 9/16:50 amMIA - MYR
1 stop5h 30mMultiple Airlines
Deal found 7/30$213
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 11/156:10 pmMYR - MIA
1 stop6h 38mAmerican Airlines
jue. 11/208:35 amMIA - MYR
1 stop5h 24mAmerican Airlines
Deal found 7/29$243
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 9/22:20 pmMYR - EYW
1 stop5h 52mDelta
mié. 9/176:10 pmEYW - MYR
1 stop5h 39mDelta
Deal found 7/28$249
This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/85:25 amMYR - EYW
1 stop5h 57mAmerican Airlines
sáb. 12/138:10 amEYW - MYR
1 stop4h 01mAmerican Airlines
Deal found 7/30$339
This Mytrip deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 9/201:15 pmMYR - EYW
2 stops19h 00mMultiple Airlines
sáb. 9/279:52 amEYW - MYR
3 stops34h 14mMultiple Airlines
Deal found 7/30$346

Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated julio 30, 2025.
Use the filters below to find and compare flights from Myrtle Beach to Florida Keys that are best for you.

Fly from

Myrtle Beach

Fly to

Florida Keys

Route

Depart

Return

Price

Myrtle BeachMiami

MYR - MIA

MYRMIA

Myrtle Beach Intl

jue. 8/21

6:50 am-5:16 pm

1 stop10h 26m

Miami

mié. 8/27

6:50 am-12:20 pm

1 stop5h 30m

$171

Myrtle BeachMiami

MYR - MIA

MYRMIA

Myrtle Beach Intl

vie. 8/29

9:35 am-8:45 pm

1 stop11h 10m

Miami

lun. 9/1

6:50 am-12:20 pm

1 stop5h 30m

$213

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

mar. 9/2

2:20 pm-8:12 pm

1 stop5h 52m

Key West

mié. 9/17

6:10 pm-11:49 pm

1 stop5h 39m

$249

Myrtle BeachMiami

MYR - MIA

MYRMIA

Myrtle Beach Intl

vie. 9/12

8:06 am-1:57 pm

1 stop5h 51m

Miami

dom. 9/14

5:18 am-10:26 am

1 stop5h 08m

$257

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

dom. 8/17

7:00 am-2:05 pm

1 stop7h 05m

Key West

sáb. 8/23

4:49 pm-9:44 pm

1 stop4h 55m

$339

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

sáb. 9/20

1:15 pm-8:15 am

2 stops19h 00m

Key West

sáb. 9/27

9:52 am-8:06 pm

3 stops34h 14m

$346

Myrtle BeachMiami

MYR - MIA

MYRMIA

Myrtle Beach Intl

sáb. 10/4

7:55 am-1:32 pm

1 stop5h 37m

$74

Myrtle BeachMiami

MYR - MIA

MYRMIA

Myrtle Beach Intl

dom. 8/3

3:50 pm-10:32 pm

1 stop6h 42m

$93

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

dom. 8/31

5:31 pm-9:43 am

2 stops16h 12m

$152

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

dom. 8/31

9:19 am-1:18 pm

1 stop3h 59m

$160

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/30

Showing 1-10 of 15 results
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2

Best time to book a flight from Myrtle Beach to Florida Keys

Have a flexible travel schedule? Discover the best time to fly to Florida Keys from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to Florida Keys

What is the cheapest month to book a flight from Myrtle Beach to Florida Keys?

Currently, August is the cheapest month in which you can book a flight from Myrtle Beach to Florida Keys (average of $328). Flying from Myrtle Beach to Florida Keys in March is currently the most expensive (average of $492). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MYR to EOA?

Find hourly flight availability from Myrtle Beach to Florida Keys. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated julio 30, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Myrtle Beach to Florida Keys as you normally would.

Reviews of airlines servicing Florida Keys

Get insights into the airlines that provide service to Florida Keys. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florida Keys. Reviews last updated julio 30, 2025.
Read through reviews of airlines operating flights from Myrtle Beach to Florida Keys, such as Southwest, Delta, and United Airlines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,241 reviews

Crew

8.6

Entertainment

7.5

Boarding

8.1

Food

7.0

Comfort

8.0

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Southwest
8.0
Very good
4,241 reviews
Southwest
8.0
Very good
4,241 reviews

Crew

8.6

Entertainment

7.5

Boarding

8.1

Food

7.0

Comfort

8.0

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Delta
8.0
Very good
7,980 reviews
Southwest
8.0
Very good
4,241 reviews

Crew

8.6

Entertainment

7.5

Boarding

8.1

Food

7.0

Comfort

8.0

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
United Airlines
7.4
Good
8,896 reviews
Southwest
8.0
Very good
4,241 reviews

Crew

8.6

Entertainment

7.5

Boarding

8.1

Food

7.0

Comfort

8.0

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,241 reviews

Crew

8.6

Entertainment

7.5

Boarding

8.1

Food

7.0

Comfort

8.0

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Spirit Airlines
6.3
Okay
8,048 reviews
Southwest
8.0
Very good
4,241 reviews

Crew

8.6

Entertainment

7.5

Boarding

8.1

Food

7.0

Comfort

8.0

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to Florida Keys. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Myrtle Beach to Florida Keys?

    Myrtle Beach Intl (MYR) is the airport you will fly out of if you book a flight from Myrtle Beach to Florida Keys. It is only a 2.1 mi journey to Myrtle Beach Intl (MYR) from Myrtle Beach’s city center.

  • What are the cheapest airlines to fly from Myrtle Beach to Florida Keys one-way?

    The cheapest airline one-way is Spirit Airlines, with whom users have recently found tickets for as low as $74. However, be on the lookout for offers from Frontier and American Airlines, as they are both options that can get you from Myrtle Beach to Florida Keys for a low price.

  • Can I find deals for flights from Myrtle Beach to Florida Keys that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to Florida Keys flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to Florida Keys?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to Florida Keys.

  • Can I find deals for business class flights from Myrtle Beach to Florida Keys?

    Yes. Cheapflights offers flight deals from Myrtle Beach to Florida Keys by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to Florida Keys?

    Currently, August is the cheapest month in which you can book a flight from Myrtle Beach to Florida Keys (average of $328). Flying from Myrtle Beach to Florida Keys in March is currently the most expensive (average of $492). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Myrtle Beach to Florida Keys

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Top 2 airlines flying from Myrtle Beach to Florida Keys

Discover the top 2 airlines that operate flights from Myrtle Beach to Florida Keys. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated julio 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$223Average$438FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$278Average$481FlexibilityNo cancel feeOn-time71%

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