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$99+ Cheap flights from Myrtle Beach (MYR) to Florida Keys

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/5. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — EYW
Nov 27 — Dec 41
Thu 11/27
Thu 12/4
1 adult, Economy
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Find flight deals from Myrtle Beach to Florida Keys

Cheapest flights from Myrtle Beach to Florida Keys
Explore the most affordable flight options available from Myrtle Beach to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 28, 2025.

This Mytrip deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1011:13 amMYR - MIA
1 stop10h 58mSpirit Airlines
Fri 11/1412:05 pmMIA - MYR
2 stops10h 21mSpirit Airlines
Deal found 10/27$193
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/29:22 amMYR - MIA
1 stop10h 25mMultiple Airlines
Thu 12/48:21 amMIA - MYR
1 stop8h 25mMultiple Airlines
Deal found 10/27$194
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1211:13 amMYR - MIA
2 stops23h 47mSpirit Airlines
Tue 11/181:02 pmMIA - MYR
1 stop21h 06mSpirit Airlines
Deal found 10/27$200
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/125:41 pmMYR - MIA
1 stop21h 22mMultiple Airlines
Tue 12/168:21 amMIA - MYR
1 stop24h 28mMultiple Airlines
Deal found 10/28$216
This Kiwi.com deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/48:27 pmMYR - MIA
2 stops27h 32mMultiple Airlines
Thu 12/118:21 amMIA - MYR
1 stop8h 25mMultiple Airlines
Deal found 10/25$217
This Mytrip deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/239:22 amMYR - MIA
1 stop13h 53mSpirit Airlines
Tue 11/2512:41 pmMIA - MYR
1 stop7h 13mSpirit Airlines
Deal found 10/27$221
This Mytrip deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/142:46 pmMYR - MIA
2 stops19h 12mSpirit Airlines
Sun 11/169:59 pmMIA - MYR
3 stops24h 27mSpirit Airlines
Deal found 10/28$222
This Mytrip deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/49:05 amMYR - MIA
1 stop5h 58mSpirit Airlines
Thu 12/48:53 pmMIA - MYR
1 stop11h 07mSpirit Airlines
Deal found 10/25$223
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/87:30 amMYR - EYW
1 stop5h 33mAmerican Airlines
Sat 12/134:53 pmEYW - MYR
1 stop7h 01mAmerican Airlines
Deal found 10/27$249
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/51:59 pmMYR - EYW
2 stops9h 08mAmerican Airlines
Wed 12/1012:00 pmEYW - MYR
2 stops8h 50mAmerican Airlines
Deal found 10/27$259
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/62:15 pmMYR - EYW
1 stop18h 00mMultiple Airlines
Mon 12/88:55 amEYW - MYR
1 stop4h 25mMultiple Airlines
Deal found 10/27$267
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/192:14 pmMYR - EYW
1 stop16h 53mBreeze Airways
Wed 12/247:47 amEYW - MYR
1 stop25h 02mBreeze Airways
Deal found 10/27$273

Cheap flight deals from Myrtle Beach to Florida Keys

Keep the following information in mind while searching for Myrtle Beach to Florida Keys flight deals. Data was last updated October 28, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$193
(Mytrip)

One-way from

$99
(Kiwi.com)

Popular in

December

Cheapest in

October

Average price

$297
Provider with most accurate pricing for Myrtle Beach Intl-Miami flight deals.
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Provider most trusted by Cheapflights users for Myrtle Beach Intl-Miami flights.
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From Myrtle Beach Intl to Florida Keys
Search Deals
One-way flight from Myrtle Beach Intl to Florida Keys
Search Deals
Highest demand for flights based on searches. 3% potential increase in price ($13 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 28, 2025.
Use the filters below to find and compare flights from Myrtle Beach to Florida Keys that are best for you.

Fly from

Myrtle Beach

Fly to

Florida Keys

Route

Depart

Return

Price

Myrtle BeachMiami

MYR - MIA

MYRMIA

Myrtle Beach Intl

Mon 11/10

11:13 am-10:11 pm

1 stop10h 58m

Miami

Fri 11/14

12:05 pm-10:26 pm

2 stops10h 21m

$193

Myrtle BeachMiami

MYR - MIA

MYRMIA

Myrtle Beach Intl

Tue 12/2

9:22 am-7:47 pm

1 stop10h 25m

Miami

Thu 12/4

8:21 am-4:46 pm

1 stop8h 25m

$194

Myrtle BeachMiami

MYR - MIA

MYRMIA

Myrtle Beach Intl

Thu 1/8

9:59 am-9:00 pm

1 stop11h 01m

Miami

Mon 1/12

8:40 pm-11:51 am

1 stop15h 11m

$199

Myrtle BeachMiami

MYR - MIA

MYRMIA

Myrtle Beach Intl

Wed 11/12

11:13 am-11:00 am

2 stops23h 47m

Miami

Tue 11/18

6:25 am-10:08 am

3 stops27h 43m

$208

Myrtle BeachMiami

MYR - MIA

MYRMIA

Myrtle Beach Intl

Fri 12/12

5:41 pm-3:03 pm

1 stop21h 22m

Miami

Tue 12/16

8:21 am-8:49 am

1 stop24h 28m

$216

Myrtle BeachMiami

MYR - MIA

MYRMIA

Myrtle Beach Intl

Thu 12/4

8:27 pm-11:59 pm

2 stops27h 32m

Miami

Thu 12/11

8:21 am-4:46 pm

1 stop8h 25m

$217

Myrtle BeachMiami

MYR - MIA

MYRMIA

Myrtle Beach Intl

Fri 12/12

9:05 am-3:03 pm

1 stop5h 58m

Miami

Tue 12/16

12:36 pm-8:49 am

2 stops20h 13m

$223

Myrtle BeachMiami

MYR - MIA

MYRMIA

Myrtle Beach Intl

Fri 1/9

4:03 pm-9:10 am

1 stop17h 07m

Miami

Mon 1/12

9:31 pm-10:41 am

2 stops13h 10m

$230

Myrtle BeachMiami

MYR - MIA

MYRMIA

Myrtle Beach Intl

Tue 12/2

2:46 pm-11:23 am

2 stops20h 37m

Miami

Thu 12/4

8:53 pm-8:00 am

1 stop11h 07m

$233

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Mon 12/8

3:29 pm-9:46 pm

1 stop6h 17m

Key West

Sat 12/13

4:53 pm-11:54 pm

1 stop7h 01m

$249

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/28

Showing 1-10 of 36 results
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Best time to book a flight from Myrtle Beach to Florida Keys

Have a flexible travel schedule? Discover the best time to fly to Florida Keys from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to Florida Keys

What is the cheapest month to book a flight from Myrtle Beach to Florida Keys?

Currently, February is the cheapest month in which you can book a flight from Myrtle Beach to Florida Keys (average of $64). Flying from Myrtle Beach to Florida Keys in April is currently the most expensive (average of $290). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MYR to EOA?

Find hourly flight availability from Myrtle Beach to Florida Keys. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 28, 2025.

One of the essential ways to save on airfare from Myrtle Beach to Florida Keys is to remain as flexible as possible. Flights that are in the evening tend to be the most expensive. A flight in the afternoon could potentially save you up to 23% on airfare.

Reviews of airlines servicing Florida Keys

Get insights into the airlines that provide service to Florida Keys. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florida Keys. Reviews last updated October 28, 2025.
Read through reviews of airlines operating flights from Myrtle Beach to Florida Keys, such as Delta, American Airlines, and Spirit Airlines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,995 reviews

Entertainment

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Comfort

7.9

Overall

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
7.9
Good
7,995 reviews
Delta
7.9
Good
7,995 reviews

Entertainment

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Comfort

7.9

Overall

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,033 reviews
Delta
7.9
Good
7,995 reviews

Entertainment

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Comfort

7.9

Overall

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Spirit Airlines
6.3
Okay
8,112 reviews
Delta
7.9
Good
7,995 reviews

Entertainment

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Comfort

7.9

Overall

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to Florida Keys. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Myrtle Beach to Florida Keys?

    Myrtle Beach Intl (MYR) is the airport you will fly out of if you book a flight from Myrtle Beach to Florida Keys. It is only a 2.1 mi journey to Myrtle Beach Intl (MYR) from Myrtle Beach’s city center.

  • How long is the flight from Myrtle Beach to Florida Keys?

    Spirit Airlines, American Airlines, and Delta can get you from Myrtle Beach to Florida Keys in just under 4h 06m. Your travel time can differ by up to 6h 52m. Myrtle Beach and Florida Keys are separated by a distance of 653 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Myrtle Beach to Florida Keys one-way?

    The cheapest airline one-way is Spirit Airlines, with whom users have recently found tickets for as low as $112. However, be on the lookout for offers from Breeze Airways and American Airlines, as they are both options that can get you from Myrtle Beach to Florida Keys for a low price.

  • Can I find deals for flights from Myrtle Beach to Florida Keys that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to Florida Keys flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to Florida Keys?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to Florida Keys.

  • Can I find deals for business class flights from Myrtle Beach to Florida Keys?

    Yes. Cheapflights offers flight deals from Myrtle Beach to Florida Keys by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to Florida Keys?

    Currently, February is the cheapest month in which you can book a flight from Myrtle Beach to Florida Keys (average of $64). Flying from Myrtle Beach to Florida Keys in April is currently the most expensive (average of $290). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 2 airlines flying from Myrtle Beach to Florida Keys

Discover the top 2 airlines that operate flights from Myrtle Beach to Florida Keys. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$223Average$438FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$279Average$479FlexibilityNo cancel feeOn-time71%

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