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$69+ Cheap flights from Myrtle Beach (MYR) to Florida Keys

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/17. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — EYW
Feb 25 — Mar 41
Wed 2/25
Wed 3/4
1 adult, Economy
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Cheap flight deals from Myrtle Beach to Florida Keys

Cheapest flights from Myrtle Beach to Florida Keys
Explore the most affordable flight options available from Myrtle Beach to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 26, 2026.

This Mytrip deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/2410:09 am
MYR
-
MIA
1 stop10h 04m
Spirit Airlines
Tue 3/38:37 pm
MIA
-
MYR
1 stop15h 48m
Spirit Airlines
Deal found 1/25$142
This CheapOair deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/710:00 am
MYR
-
MIA
1 stop10h 13m
Spirit Airlines
Sat 2/141:24 pm
MIA
-
MYR
1 stop10h 33m
Spirit Airlines
Deal found 1/26$163
This CheapOair deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/310:09 am
MYR
-
MIA
1 stop10h 04m
Spirit Airlines
Fri 3/66:02 am
MIA
-
MYR
1 stop26h 56m
Spirit Airlines
Deal found 1/24$167
This CheapOair deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/710:00 am
MYR
-
MIA
1 stop10h 13m
Spirit Airlines
Sun 2/151:24 pm
MIA
-
MYR
1 stop10h 33m
Spirit Airlines
Deal found 1/24$169
This CheapOair deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/186:15 am
MYR
-
MIA
1 stop6h 04m
Spirit Airlines
Thu 2/192:52 pm
MIA
-
MYR
1 stop9h 05m
Spirit Airlines
Deal found 1/24$175
This Kiwi.com deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/78:15 pm
MYR
-
MIA
2 stops21h 33m
Multiple Airlines
Sat 2/146:00 am
MIA
-
MYR
1 stop17h 57m
Multiple Airlines
Deal found 1/24$177
This Kiwi.com deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/1410:01 am
MYR
-
MIA
1 stop9h 15m
Multiple Airlines
Mon 3/166:49 pm
MIA
-
MYR
1 stop19h 43m
Multiple Airlines
Deal found 1/24$181
This CheapOair deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/216:15 am
MYR
-
MIA
1 stop6h 04m
Spirit Airlines
Sat 2/286:02 am
MIA
-
MYR
1 stop14h 37m
Spirit Airlines
Deal found 1/24$182
This Kiwi.com deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/229:09 am
MYR
-
EYW
1 stop4h 21m
Spirit Airlines
Fri 2/272:25 pm
EYW
-
MYR
1 stop17h 48m
Spirit Airlines
Deal found 1/25$239
This Kiwi.com deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/2811:54 am
MYR
-
EYW
1 stop21h 12m
Multiple Airlines
Mon 3/22:25 pm
EYW
-
MYR
1 stop17h 48m
Multiple Airlines
Deal found 1/26$245
This Kiwi.com deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/66:37 pm
MYR
-
EYW
1 stop16h 53m
Spirit Airlines
Thu 4/912:25 pm
EYW
-
MYR
1 stop5h 14m
Spirit Airlines
Deal found 1/25$255
This Kiwi.com deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/229:09 am
MYR
-
EYW
1 stop4h 21m
Multiple Airlines
Fri 2/271:06 pm
EYW
-
MYR
2 stops21h 56m
Multiple Airlines
Deal found 1/25$257

Find flight deals from Myrtle Beach to Florida Keys

Keep the following information in mind while searching for Myrtle Beach to Florida Keys flight deals. Data was last updated January 26, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

Expedia
3 stars

Round-trip from

$142
(Mytrip)

One-way from

$69
(Mytrip)

Popular in

June

Cheapest in

October

Average price

$328
Provider with most accurate pricing for Myrtle Beach Intl-Miami flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Miami flights.
Search Deals
From Myrtle Beach Intl to Florida Keys
Search Deals
One-way flight from Myrtle Beach Intl to Florida Keys
Search Deals
Highest demand for flights based on searches. 4% potential increase in price ($15 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($5 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 26, 2026.
Use the filters below to find and compare flights from Myrtle Beach to Florida Keys that are best for you.

Fly from

Myrtle Beach

Fly to

Florida Keys

Route

Depart

Return

Price

Myrtle BeachMiami

MYR - MIA

MYRMIA

Myrtle Beach Intl

Tue 3/3

10:09 am-8:13 pm

1 stop10h 04m

Miami

Fri 3/6

6:02 am-8:58 am

1 stop26h 56m

$167

Myrtle BeachMiami

MYR - MIA

MYRMIA

Myrtle Beach Intl

Sat 2/7

10:00 am-8:13 pm

1 stop10h 13m

Miami

Sun 2/15

1:24 pm-11:57 pm

1 stop10h 33m

$170

Myrtle BeachMiami

MYR - MIA

MYRMIA

Myrtle Beach Intl

Sun 2/22

6:15 am-12:14 am

1 stop17h 59m

Miami

Tue 2/24

8:37 pm-12:25 pm

1 stop15h 48m

$175

Myrtle BeachMiami

MYR - MIA

MYRMIA

Myrtle Beach Intl

Sat 3/14

10:01 am-7:16 pm

1 stop9h 15m

Miami

Mon 3/16

6:49 pm-2:32 pm

1 stop19h 43m

$181

Myrtle BeachMiami

MYR - MIA

MYRMIA

Myrtle Beach Intl

Tue 3/3

10:09 am-8:13 pm

1 stop10h 04m

Miami

Fri 3/6

12:16 pm-8:13 am

2 stops19h 57m

$185

Myrtle BeachMiami

MYR - MIA

MYRMIA

Myrtle Beach Intl

Mon 2/23

6:15 am-8:13 pm

1 stop13h 58m

Miami

Tue 2/24

7:05 am-8:13 am

2 stops25h 08m

$191

Myrtle BeachMiami

MYR - MIA

MYRMIA

Myrtle Beach Intl

Wed 2/25

1:20 pm-9:32 pm

1 stop8h 12m

Miami

Sun 3/1

5:05 am-8:13 am

2 stops27h 08m

$192

Myrtle BeachMiami

MYR - MIA

MYRMIA

Myrtle Beach Intl

Tue 2/24

9:09 am-12:16 pm

2 stops27h 07m

Miami

Tue 3/3

9:53 pm-2:55 pm

2 stops17h 02m

$194

Myrtle BeachMiami

MYR - MIA

MYRMIA

Myrtle Beach Intl

Sat 5/2

9:53 am-7:25 pm

1 stop9h 32m

Miami

Wed 5/6

11:55 am-6:26 pm

1 stop6h 31m

$205

Myrtle BeachMiami

MYR - MIA

MYRMIA

Myrtle Beach Intl

Wed 4/29

9:53 am-7:25 pm

1 stop9h 32m

Miami

Fri 5/1

11:55 am-6:26 pm

1 stop6h 31m

$205

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/25

Showing 1-10 of 33 results
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Best time to book a flight from Myrtle Beach to Florida Keys

Have a flexible travel schedule? Discover the best time to fly to Florida Keys from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to Florida Keys

What is the cheapest month to book a flight from Myrtle Beach to Florida Keys?

Currently, February is the cheapest month in which you can book a flight from Myrtle Beach to Florida Keys (average of $64). Flying from Myrtle Beach to Florida Keys in April is currently the most expensive (average of $259). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Florida Keys

Get insights into the airlines that provide service to Florida Keys. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florida Keys. Reviews last updated January 26, 2026.
Read through reviews of airlines operating flights from Myrtle Beach to Florida Keys, such as Delta, American Airlines, and Spirit Airlines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,113 reviews

Crew

8.5

Food

7.2

Boarding

8.1

Comfort

7.9

Entertainment

7.8

Overall

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
7.9
Good
8,113 reviews
Delta
7.9
Good
8,113 reviews

Crew

8.5

Food

7.2

Boarding

8.1

Comfort

7.9

Entertainment

7.8

Overall

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,189 reviews
Delta
7.9
Good
8,113 reviews

Crew

8.5

Food

7.2

Boarding

8.1

Comfort

7.9

Entertainment

7.8

Overall

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Spirit Airlines
6.3
Okay
8,379 reviews
Delta
7.9
Good
8,113 reviews

Crew

8.5

Food

7.2

Boarding

8.1

Comfort

7.9

Entertainment

7.8

Overall

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to Florida Keys. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Myrtle Beach to Florida Keys?

    Myrtle Beach Intl (MYR) is the airport you will fly out of if you book a flight from Myrtle Beach to Florida Keys. It is only a 2.1 mi journey to Myrtle Beach Intl (MYR) from Myrtle Beach’s city center.

  • How long is the flight from Myrtle Beach to Florida Keys?

    Spirit Airlines can get you from Myrtle Beach to Florida Keys in just under 10h 04m. Your travel time can differ by up to . Myrtle Beach and Florida Keys are separated by a distance of 551 mi.

  • What are the cheapest airlines to fly from Myrtle Beach to Florida Keys one-way?

    The cheapest airline one-way is Spirit Airlines, with whom users have recently found tickets for as low as $45. However, be on the lookout for offers from American Airlines and Delta, as they are both options that can get you from Myrtle Beach to Florida Keys for a low price.

  • Can I find deals for flights from Myrtle Beach to Florida Keys that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to Florida Keys flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to Florida Keys?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to Florida Keys.

  • Can I find deals for business class flights from Myrtle Beach to Florida Keys?

    Yes. Cheapflights offers flight deals from Myrtle Beach to Florida Keys by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to Florida Keys?

    Currently, February is the cheapest month in which you can book a flight from Myrtle Beach to Florida Keys (average of $64). Flying from Myrtle Beach to Florida Keys in April is currently the most expensive (average of $259). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Myrtle Beach to Florida Keys

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Top 2 airlines flying from Myrtle Beach to Florida Keys

Discover the top 2 airlines that operate flights from Myrtle Beach to Florida Keys. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 26, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$223Average$438FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$263Average$439FlexibilityNo cancel feeOn-time71%

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