HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Florida Keys

$117+ Cheap flights from Greenville (GSP) to Florida Keys

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/9. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — EYW
Feb 14 — Feb 211
Sat 2/14
Sat 2/21
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Greenville to Florida Keys with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Greenville to Florida Keys

Keep the following information in mind while searching for Greenville to Florida Keys flight deals. Data was last updated January 15, 2026.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$179
(American Airlines)

One-way from

$117
(Kiwi.com)

Popular in

November

Cheapest in

January

Average price

$355
Provider with most accurate pricing for Greenville-Miami flight deals.
Search Deals
Provider most trusted by Cheapflights users for Greenville-Miami flights.
Search Deals
From Greenville to Florida Keys
Search Deals
One-way flight from Greenville to Florida Keys
Search Deals
Highest demand for flights based on searches. 4% potential increase in price ($16 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 0% potential price decrease ($2 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Find flight deals from Greenville to Florida Keys

Cheapest flights from Greenville to Florida Keys
Explore the most affordable flight options available from Greenville to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 15, 2026.

This Kiwi.com deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/234:07 pm
GSP
-
EYW
1 stop18h 02m
Breeze Airways
Fri 1/309:49 am
EYW
-
GSP
1 stop10h 18m
Breeze Airways
Deal found 1/15$158
This Kiwi.com deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/234:07 pm
GSP
-
EYW
1 stop18h 02m
Breeze Airways
Mon 1/269:49 am
EYW
-
GSP
1 stop10h 18m
Breeze Airways
Deal found 1/14$165
This American Airlines deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/177:26 pm
GSP
-
MIA
Nonstop1h 57m
American Airlines
Tue 2/244:48 pm
MIA
-
GSP
Nonstop2h 08m
American Airlines
Deal found 1/14$179
This American Airlines deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/116:56 pm
GSP
-
MIA
Nonstop2h 03m
American Airlines
Wed 2/184:48 pm
MIA
-
GSP
Nonstop2h 08m
American Airlines
Deal found 1/13$189
This Delta deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/173:00 pm
GSP
-
MIA
1 stop5h 44m
Delta
Tue 2/241:28 pm
MIA
-
GSP
1 stop6h 51m
Delta
Deal found 1/15$199
This American Airlines deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/227:26 pm
GSP
-
MIA
Nonstop1h 57m
American Airlines
Mon 3/24:48 pm
MIA
-
GSP
Nonstop2h 08m
American Airlines
Deal found 1/14$229
This American Airlines deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/116:00 am
GSP
-
MIA
1 stop4h 12m
American Airlines
Wed 2/2510:09 pm
MIA
-
GSP
Nonstop2h 13m
American Airlines
Deal found 1/14$234
This Delta deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/225:40 am
GSP
-
MIA
1 stop3h 46m
Delta
Sat 2/287:15 am
MIA
-
GSP
1 stop5h 36m
Delta
Deal found 1/13$239
This Delta deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/115:40 am
GSP
-
MIA
1 stop3h 46m
Delta
Wed 2/257:15 am
MIA
-
GSP
1 stop6h 47m
Delta
Deal found 1/13$249
This Kiwi.com deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/52:58 pm
GSP
-
EYW
1 stop23h 55m
Multiple Airlines
Mon 3/91:06 pm
EYW
-
GSP
1 stop6h 32m
Multiple Airlines
Deal found 1/13$259
This American Airlines deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/227:26 pm
GSP
-
MIA
Nonstop1h 57m
American Airlines
Sat 2/281:40 pm
MIA
-
GSP
Nonstop2h 13m
American Airlines
Deal found 1/13$264
This Kiwi.com deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/136:22 pm
GSP
-
EYW
2 stops38h 44m
Multiple Airlines
Fri 2/201:06 pm
EYW
-
GSP
1 stop6h 32m
Multiple Airlines
Deal found 1/14$268

Cheapflights Fare Finder

 
Customize your flight search to find flights from Greenville to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 15, 2026.
Use the filters below to find and compare flights from Greenville to Florida Keys that are best for you.

Fly from

Greenville

Fly to

Florida Keys

Route

Depart

Return

Price

GreenvilleMiami

GSP - MIA

GSPMIA

Greenville

Sun 2/22

5:40 am-9:26 am

1 stop3h 46m

Miami

Sat 2/28

7:15 am-12:51 pm

1 stop5h 36m

$239

GreenvilleKey West

GSP - EYW

GSPEYW

Greenville

Thu 2/19

3:04 pm-2:47 pm

1 stop23h 43m

Key West

Mon 2/23

9:49 am-8:07 pm

1 stop10h 18m

$268

GreenvilleKey West

GSP - EYW

GSPEYW

Greenville

Thu 5/7

6:45 pm-10:57 pm

1 stop4h 12m

Key West

Tue 5/12

11:24 am-6:15 pm

1 stop6h 51m

$269

GreenvilleKey West

GSP - EYW

GSPEYW

Greenville

Fri 5/8

3:42 pm-7:44 pm

1 stop4h 02m

Key West

Mon 5/11

2:35 pm-9:25 pm

1 stop6h 50m

$269

GreenvilleKey West

GSP - EYW

GSPEYW

Greenville

Tue 2/3

6:56 pm-11:56 pm

1 stop5h 00m

Key West

Tue 2/10

7:45 pm-11:57 pm

1 stop4h 12m

$274

GreenvilleKey West

GSP - EYW

GSPEYW

Greenville

Tue 5/5

5:40 am-10:52 am

1 stop5h 12m

Key West

Mon 5/11

2:35 pm-9:25 pm

1 stop6h 50m

$279

GreenvilleKey West

GSP - EYW

GSPEYW

Greenville

Wed 4/29

6:00 am-12:42 pm

1 stop6h 42m

Key West

Mon 5/11

2:35 pm-9:25 pm

1 stop6h 50m

$289

GreenvilleKey West

GSP - EYW

GSPEYW

Greenville

Sat 5/2

6:45 pm-10:57 pm

1 stop4h 12m

Key West

Wed 5/6

11:24 am-6:15 pm

1 stop6h 51m

$294

GreenvilleMiami

GSP - MIA

GSPMIA

Greenville

Tue 1/27

10:05 am-4:10 pm

1 stop6h 05m

Miami

Fri 1/30

7:55 am-5:35 pm

1 stop9h 40m

$295

GreenvilleMiami

GSP - MIA

GSPMIA

Greenville

Fri 1/30

10:05 am-4:10 pm

1 stop6h 05m

Miami

Mon 2/2

7:55 am-5:35 pm

1 stop9h 40m

$295

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/12

Showing 1-10 of 39 results
1
2
3
4

Best time to book a flight from Greenville to Florida Keys

Have a flexible travel schedule? Discover the best time to fly to Florida Keys from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to Florida Keys

What is the cheapest month to book a flight from Greenville to Florida Keys?

Currently, January is the cheapest month in which you can book a flight from Greenville to Florida Keys (average of $86). Flying from Greenville to Florida Keys in December is currently the most expensive (average of $107). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Florida Keys

Get insights into the airlines that provide service to Florida Keys. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florida Keys. Reviews last updated January 15, 2026.
Get a feel of what it's like to fly with Southwest, Delta, and American Airlines from Greenville to Florida Keys by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,258 reviews

Food

7.0

Overall

8.0

Boarding

8.1

Crew

8.6

Comfort

8.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Southwest
8.0
Very good
4,258 reviews
Southwest
8.0
Very good
4,258 reviews

Food

7.0

Overall

8.0

Boarding

8.1

Crew

8.6

Comfort

8.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Delta
7.9
Good
8,044 reviews
Southwest
8.0
Very good
4,258 reviews

Food

7.0

Overall

8.0

Boarding

8.1

Crew

8.6

Comfort

8.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
American Airlines
7.2
Good
11,125 reviews
Southwest
8.0
Very good
4,258 reviews

Food

7.0

Overall

8.0

Boarding

8.1

Crew

8.6

Comfort

8.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Allegiant Air
7.2
Good
702 reviews
Southwest
8.0
Very good
4,258 reviews

Food

7.0

Overall

8.0

Boarding

8.1

Crew

8.6

Comfort

8.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

Find useful and relevant information for your journey from Greenville to Florida Keys. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Greenville to Florida Keys?

    If you book a flight to Florida Keys from Greenville, you will be flying from Greenville, which is the city’s only airport. Greenville (GSP) is located 10.4 mi from the center of Greenville.

  • How long is the flight from Greenville to Florida Keys?

    There are many flights that can get you from Greenville to Florida Keys in 3h 46m. Fly via Delta, American Airlines, or Southwest to get the fastest option. The distance from Greenville to Florida Keys is about 639 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Greenville to Florida Keys one-way?

    To fly one-way, consider booking your trip with Allegiant Air, which is currently one of the cheapest options available, starting at $39. American Airlines flights start at $121 while deals on Delta start at $127 one-way.

  • Can I find deals for flights from Greenville to Florida Keys that include hotel bookings?

    Yes. In addition to deals on Greenville to Florida Keys flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to Florida Keys?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to Florida Keys.

  • Can I find deals for business class flights from Greenville to Florida Keys?

    Yes. Cheapflights offers flight deals from Greenville to Florida Keys by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Greenville to Florida Keys?

    Currently, January is the cheapest month in which you can book a flight from Greenville to Florida Keys (average of $86). Flying from Greenville to Florida Keys in December is currently the most expensive (average of $107). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Greenville to Florida Keys

See prices for flight routes from nearby airports that may be better suited for you.
Charlotte to Fort Lauderdale flights
Charlotte to Miami flights
Charlotte to Orlando flights
Charlotte to Tampa flights
Charlotte to West Palm Beach flights
Charleston to Fort Lauderdale flights
Charlotte to Fort Myers flights
Charleston to Miami flights
Charlotte to Sarasota flights
Greenville to Miami flights
Columbia to Orlando flights
Charlotte to Key West flights
Columbia to Miami flights
Charleston to Tampa flights
Myrtle Beach to Fort Lauderdale flights
Charleston to Orlando flights
Savannah to Miami flights
Charlotte to Jacksonville flights
Myrtle Beach to Orlando flights
Myrtle Beach to Miami flights
Greenville to Orlando flights
Myrtle Beach to Tampa flights
Charlotte to Pensacola flights
Charlotte to Panama City flights
Columbia to Tampa flights
Savannah to Orlando flights
Greenville to Tampa flights
Charleston to West Palm Beach flights
Charlotte to Valparaiso flights
Charleston to Key West flights
Greenville to Key West flights
Myrtle Beach to Fort Myers flights
Myrtle Beach to West Palm Beach flights
Columbia to Fort Lauderdale flights
Charleston to Fort Myers flights
Columbia to West Palm Beach flights
Greenville to West Palm Beach flights
Charlotte to Daytona Beach flights
Greenville to Fort Lauderdale flights
Augusta to Fort Lauderdale flights
Myrtle Beach to Sarasota flights
Savannah to Fort Lauderdale flights
Charleston to Sarasota flights
Savannah to Tampa flights
Greenville to St Petersburg flights
Greenville to Pensacola flights
Columbia to Key West flights
Savannah to West Palm Beach flights
Greenville to Melbourne flights
Augusta to Miami flights

Top 2 airlines flying from Greenville to Florida Keys

Discover the top 2 airlines that operate flights from Greenville to Florida Keys. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 15, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$248Average$390FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$253Average$399FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.