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$458+ Cheap flights from Orlando (MCO) to Florence, SC (FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/26. Fares are subject to change and may not be available on all flights or dates of travel.
MCO — FLO
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheap flight deals from Orlando to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Orlando (MCO) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$458
(American Airlines)
From Orlando to Florence
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Find flight deals from Orlando to Florence

Cheapest flights from Orlando to Florence
Explore the most affordable flight options available from Orlando to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/2612:11 pmMCO - FLO
2 stops11h 05mAmerican Airlines
Tue 9/306:14 amFLO - MCO
2 stops13h 30mAmerican Airlines
Deal found 9/11$458
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/2412:47 pmMCO - FLO
1 stop4h 25mAmerican Airlines
Sun 9/285:14 amFLO - MCO
1 stop6h 35mAmerican Airlines
Deal found 9/9$472

Cheapflights Fare Finder

 
Customize your flight search to find flights from Orlando to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Orlando Airport to Florence that are best for you.

Fly from

Orlando

Fly to

Florence

Route

Depart

Return

Price

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Fri 9/26

12:11 pm-11:16 pm

2 stops11h 05m

Florence

Tue 9/30

6:14 am-7:44 pm

2 stops13h 30m

$458

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Wed 9/24

12:47 pm-5:12 pm

1 stop4h 25m

Florence

Sun 9/28

5:14 am-11:49 am

1 stop6h 35m

$472

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/11

Best time to book a flight from Orlando to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Orlando with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Orlando Airport to Florence

What is the cheapest month to book a flight from Orlando Airport to Florence, South Carolina?

Currently, January is the cheapest month in which you can book a flight from Orlando Airport to Florence, South Carolina (average of $366). Flying from Orlando Airport to Florence, South Carolina in October is currently the most expensive (average of $501). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Orlando to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Orlando?

    For a flight from Orlando to Florence, you will be flying into Florence. Florence (FLO) is just 2.3 mi from the center of the city. Florence is the only Florence airport and it handles 0 inbound flights from Orlando per day. 0 airlines have flights to Florence from Orlando on a regular basis.

  • How long is the flight from Orlando Airport to Florence, South Carolina?

    For as low as $458, American Airlines can have you in Florence, South Carolina from Orlando Airport in 11h 05m. Orlando Airport and Florence, South Carolina are separated by a distance of 408 mi.

  • Can I find deals for flights from Orlando to Florence that include hotel bookings?

    Yes. In addition to deals on Orlando to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Orlando to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Orlando to Florence.

  • Can I find deals for business class flights from Orlando to Florence?

    Yes. Cheapflights offers flight deals from Orlando to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Orlando Airport to Florence, South Carolina?

    Currently, January is the cheapest month in which you can book a flight from Orlando Airport to Florence, South Carolina (average of $366). Flying from Orlando Airport to Florence, South Carolina in October is currently the most expensive (average of $501). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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