HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Florence

$362+ Cheap flights from Orlando (MCO) to Florence, SC (FLO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/11. Fares are subject to change and may not be available on all flights or dates of travel.
MCO — FLO
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Orlando to Florence with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Find flight deals from Orlando to Florence

Cheapest flights from Orlando to Florence
Explore the most affordable flight options available from Orlando to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/255:00 amMCO - FLO
1 stop5h 45mAmerican Airlines
Tue 12/26:15 amFLO - MCO
1 stop3h 52mAmerican Airlines
Deal found 10/28$417
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/41:53 pmMCO - FLO
1 stop4h 12mAmerican Airlines
Wed 12/106:15 amFLO - MCO
1 stop3h 51mAmerican Airlines
Deal found 10/29$471
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/207:41 pmMCO - FLO
1 stop4h 00mAmerican Airlines
Sun 11/2311:11 amFLO - MCO
1 stop4h 14mAmerican Airlines
Deal found 10/30$517

Cheap flight deals from Orlando to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Orlando (MCO) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 30, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$417
(American Airlines)

One-way from

$362
(American Airlines)
Provider with most accurate pricing for Orlando-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Orlando-Florence flights.
Search Deals
From Orlando to Florence
Search Deals
One-way flight from Orlando to Florence
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Orlando to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Orlando Airport to Florence that are best for you.

Fly from

Orlando

Fly to

Florence

Route

Depart

Return

Price

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Tue 11/25

3:01 pm-11:41 pm

2 stops8h 40m

Florence

Tue 12/2

10:29 am-2:01 pm

1 stop3h 32m

$422

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Thu 12/4

1:53 pm-6:05 pm

1 stop4h 12m

Florence

Wed 12/10

6:15 am-10:06 am

1 stop3h 51m

$471

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Thu 11/20

7:41 pm-11:41 pm

1 stop4h 00m

Florence

Sun 11/23

11:11 am-3:25 pm

1 stop4h 14m

$517

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Tue 11/11

6:00 am-10:47 am

1 stop4h 47m

$362

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Wed 11/12

6:00 am-9:54 am

1 stop3h 54m

$362

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Mon 11/10

9:10 am-5:09 pm

2 stops7h 59m

$456

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/29

Compare providers for flights from Orlando to Florence

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Orlando to Florence in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Orlando Airport-Florence, South Carolina flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Orlando Airport-Florence, South Carolina flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Orlando Airport-Florence, South Carolina flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Orlando Airport-Florence, South Carolina flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Orlando Airport-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Orlando to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Orlando with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Orlando Airport to Florence

What is the cheapest month to book a flight from Orlando Airport to Florence, South Carolina?

Currently, December is the cheapest month in which you can book a flight from Orlando Airport to Florence, South Carolina (average of $39). Flying from Orlando Airport to Florence, South Carolina in June is currently the most expensive (average of $76). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Orlando to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Orlando?

    For a flight from Orlando to Florence, you will be flying into Florence. Florence (FLO) is just 2.3 mi from the center of the city. Florence is the only Florence airport and it handles 0 inbound flights from Orlando per day. 0 airlines have flights to Florence from Orlando on a regular basis.

  • How long is the flight from Orlando Airport to Florence, South Carolina?

    For as low as $422, American Airlines can have you in Florence, South Carolina from Orlando Airport in 8h 40m. Orlando Airport and Florence, South Carolina are separated by a distance of 408 mi.

  • Can I find deals for flights from Orlando to Florence that include hotel bookings?

    Yes. In addition to deals on Orlando to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Orlando to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Orlando to Florence.

  • Can I find deals for business class flights from Orlando to Florence?

    Yes. Cheapflights offers flight deals from Orlando to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Orlando Airport to Florence, South Carolina?

    Currently, December is the cheapest month in which you can book a flight from Orlando Airport to Florence, South Carolina (average of $39). Flying from Orlando Airport to Florence, South Carolina in June is currently the most expensive (average of $76). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.