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Des Moines

$450+ Cheap flights from Prague (PRG) to Des Moines (DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/22. Fares are subject to change and may not be available on all flights or dates of travel.
PRG — DSM
Nov 28 — Dec 51
Fri 11/28
Fri 12/5
1 adult, Economy
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Find flight deals from Prague to Des Moines

Cheapest flights from Prague to Des Moines
Explore the most affordable flight options available from Prague to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 29, 2025.

This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/77:35 amPRG - DSM
2 stops16h 50mUnited Airlines
Tue 11/115:14 pmDSM - PRG
2 stops22h 11mUnited Airlines
Deal found 10/28$985
This Gotogate deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1211:40 amPRG - DSM
2 stops19h 05mAer Lingus
Fri 12/195:45 amDSM - PRG
2 stops22h 15mAer Lingus
Deal found 10/28$1,228
This Mytrip deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/129:30 pmPRG - DSM
3 stops31h 59mMultiple Airlines
Fri 12/198:05 amDSM - PRG
3 stops28h 25mMultiple Airlines
Deal found 10/28$1,633

Cheap flight deals from Prague to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Prague (PRG) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 29, 2025.

Most accurate provider

Expedia
2 stars

Most trusted provider

Expedia
3 stars

Round-trip from

$1,228
(Gotogate)

One-way from

$450
(Kiwi.com)
Provider with most accurate pricing for Václav Havel Prague-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Václav Havel Prague-Des Moines flights.
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From Václav Havel Prague to Des Moines
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One-way flight from Václav Havel Prague to Des Moines
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Prague to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 29, 2025.
Use the filters below to find and compare flights from Prague to Des Moines that are best for you.

Fly from

Prague

Fly to

Des Moines

Route

Depart

Return

Price

PragueDes Moines

PRG - DSM

PRGDSM

Václav Havel Prague

Fri 12/12

11:40 am-11:45 pm

2 stops19h 05m

Des Moines

Fri 12/19

5:45 am-11:00 am

2 stops22h 15m

$1,228

PragueDes Moines

PRG - DSM

PRGDSM

Václav Havel Prague

Fri 12/12

9:30 pm-10:29 pm

3 stops31h 59m

Des Moines

Fri 12/19

8:05 am-7:30 pm

3 stops28h 25m

$1,633

PragueDes Moines

PRG - DSM

PRGDSM

Václav Havel Prague

Mon 12/8

8:15 am-12:35 pm

3 stops59h 20m

$504

PragueDes Moines

PRG - DSM

PRGDSM

Václav Havel Prague

Thu 1/22

6:50 pm-5:08 pm

2 stops53h 18m

$533

PragueDes Moines

PRG - DSM

PRGDSM

Václav Havel Prague

Mon 12/1

6:00 am-8:47 pm

3 stops21h 47m

$729

PragueDes Moines

PRG - DSM

PRGDSM

Václav Havel Prague

Mon 12/8

11:40 am-11:52 pm

2 stops19h 12m

$843

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/27

  • Most accurate provider: When it comes to deals on Prague-Des Moines flights, users find the pricing of Expedia to be most consistent on Cheapflights vs. Expedia Users can find the same prices on Prague-Des Moines flight deals on Cheapflights vs. Expedia 90-95% of the time. Price accuracy is based on data collected from Prague-Des Moines flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Prague-Des Moines flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Prague-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Prague to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Prague with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Prague to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Prague to Des Moines?

    Aer Lingus can get you from Prague to Des Moines in just under 19h 05m. Your travel time can differ by up to . There are 4753 mi between Prague and Des Moines.

  • Can I find deals for flights from Prague to Des Moines that include hotel bookings?

    Yes. In addition to deals on Prague to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Prague to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Prague to Des Moines.

  • Can I find deals for business class flights from Prague to Des Moines?

    Yes. Cheapflights offers flight deals from Prague to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Johnston
Altoona
Boone
Ames
West Des Moines
Ankeny

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