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$509+ Cheap flights from Des Moines (DSM) to the Czech Republic

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/6. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — PRG
Mar 23 — Mar 301
Mon 3/23
Mon 3/30
1 adult, Economy
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Cheap flight deals from Des Moines to Czech Republic

Cheapest flights from Des Moines to Czech Republic
Explore the most affordable flight options available from Des Moines to Czech Republic. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 21, 2026.

This oojo deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/15:01 pm
DSM
-
PRG
2 stops22h 49m
British Airways
Sun 5/109:20 pm
PRG
-
DSM
2 stops33h 29m
British Airways
Deal found 2/18$597
This United Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/111:40 am
DSM
-
PRG
2 stops14h 15m
United Airlines
Sun 5/109:10 am
PRG
-
DSM
2 stops20h 35m
United Airlines
Deal found 2/19$611
This FlightHub deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/202:15 pm
DSM
-
PRG
2 stops36h 25m
Scandinavian Airlines
Fri 9/253:20 pm
PRG
-
DSM
2 stops38h 06m
Scandinavian Airlines
Deal found 2/21$621
This Gurufare deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gurufare is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/18:10 pm
DSM
-
PRG
2 stops20h 00m
Lufthansa
Sun 5/102:10 pm
PRG
-
DSM
2 stops15h 59m
Lufthansa
Deal found 2/20$634
This United Airlines deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/45:03 pm
DSM
-
PRG
2 stops16h 02m
United Airlines
Sun 3/87:25 am
PRG
-
DSM
2 stops20h 15m
United Airlines
Deal found 2/17$711
This Billigflug deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Billigflug is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/73:21 pm
DSM
-
PRG
2 stops14h 24m
Multiple Airlines
Tue 4/146:10 am
PRG
-
DSM
2 stops15h 15m
Multiple Airlines
Deal found 2/20$730
This KLM deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/75:47 pm
DSM
-
PRG
2 stops16h 53m
KLM
Tue 4/146:00 am
PRG
-
DSM
2 stops16h 41m
KLM
Deal found 2/20$754
This Delta deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/76:15 am
DSM
-
PRG
2 stops21h 15m
Delta
Tue 4/146:00 am
PRG
-
DSM
2 stops16h 41m
Delta
Deal found 2/21$762
This Delta deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/610:51 am
DSM
-
PRG
2 stops19h 54m
Delta
Mon 4/132:30 pm
PRG
-
DSM
2 stops32h 11m
Delta
Deal found 2/20$763
This ResecentrumGruppen deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure ResecentrumGruppen is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/56:59 pm
DSM
-
PRG
2 stops19h 21m
Lufthansa
Sun 4/122:10 pm
PRG
-
DSM
2 stops15h 49m
Lufthansa
Deal found 2/18$766
This FlightHub deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/3111:04 am
DSM
-
PRG
2 stops39h 36m
Scandinavian Airlines
Sun 9/63:20 pm
PRG
-
DSM
2 stops38h 06m
Scandinavian Airlines
Deal found 2/18$787

Find flight deals from Des Moines to Czech Republic

Keep the following information in mind while searching for Des Moines to Czech Republic flight deals. Data was last updated February 21, 2026.

Round-trip from

$597
(oojo)

One-way from

$509
(Gotogate)
From Des Moines to Czech Republic
Search Deals
One-way flight from Des Moines to Czech Republic
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Czech Republic that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 21, 2026.
Use the filters below to find and compare flights from Des Moines to the Czech Republic that are best for you.

Fly from

Des Moines

Fly to

Czech Republic

Route

Depart

Return

Price

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Fri 5/1

5:01 pm-10:50 pm

2 stops22h 49m

Václav Havel Prague

Sun 5/10

9:20 pm-11:49 pm

2 stops33h 29m

$597

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Fri 5/1

11:40 am-8:55 am

2 stops14h 15m

Václav Havel Prague

Sun 5/10

9:10 am-10:45 pm

2 stops20h 35m

$611

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 3/4

8:00 am-4:05 pm

3 stops25h 05m

Václav Havel Prague

Sun 3/8

7:25 am-8:40 pm

2 stops20h 15m

$711

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Tue 4/7

5:47 pm-5:40 pm

2 stops16h 53m

Václav Havel Prague

Tue 4/14

6:00 am-3:41 pm

2 stops16h 41m

$754

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Tue 4/7

6:15 am-10:30 am

2 stops21h 15m

Václav Havel Prague

Tue 4/14

6:00 am-3:41 pm

2 stops16h 41m

$762

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Mon 4/6

6:15 am-10:30 am

2 stops21h 15m

Václav Havel Prague

Mon 4/13

2:30 pm-3:41 pm

2 stops32h 11m

$763

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Sun 4/5

1:10 pm-5:55 pm

2 stops21h 45m

Václav Havel Prague

Sun 4/12

2:10 pm-10:59 pm

2 stops15h 49m

$794

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Sun 4/5

6:59 pm-9:20 pm

2 stops19h 21m

Václav Havel Prague

Sun 4/12

2:10 pm-10:59 pm

2 stops15h 49m

$799

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Mon 4/6

7:04 pm-4:05 pm

2 stops14h 01m

$509

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Sun 3/15

7:00 am-4:05 pm

2 stops27h 05m

$511

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/20

Showing 1-10 of 12 results
1
2

Best time to book a flight from Des Moines to Czech Republic

Have a flexible travel schedule? Discover the best time to fly to Czech Republic from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to the Czech Republic
No data available for this route at this time. Please check back soon.

Reviews of airlines servicing Czech Republic

Get insights into the airlines that provide service to Czech Republic. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Czech Republic. Reviews last updated February 21, 2026.
Read through reviews of airlines operating flights from Des Moines to the Czech Republic, such as United Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,335 reviews

Comfort

7.3

Boarding

7.7

Entertainment

7.1

Overall

7.4

Crew

8.1

Food

6.6

Reviews

1 / 20
10.0
Excellent

Dane,Jan 2026

TYS - IAD

It was a short flight, so no time for amenities. Just glad everything was quick and easy from boarding to arriving at my destination with my family
United Airlines
7.4
Good
9,335 reviews
United Airlines
7.4
Good
9,335 reviews

Comfort

7.3

Boarding

7.7

Entertainment

7.1

Overall

7.4

Crew

8.1

Food

6.6

Reviews

1 / 20
10.0
Excellent

Dane,Jan 2026

TYS - IAD

It was a short flight, so no time for amenities. Just glad everything was quick and easy from boarding to arriving at my destination with my family

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Czech Republic. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Czech Republic?

    Most people fly from Des Moines (DSM) if they book a flight from Des Moines to Czech Republic. Des Moines is conveniently located just 3.6 mi from Des Moines’s city center.

  • How long is the flight from Des Moines to Czech Republic?

    For as low as $611, British Airways can have you in Czech Republic from Des Moines in 14h 15m. The distance from Des Moines to Czech Republic is about 4753 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Des Moines to Czech Republic that include hotel bookings?

    Yes. In addition to deals on Des Moines to Czech Republic flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Czech Republic?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Czech Republic.

  • Can I find deals for business class flights from Des Moines to Czech Republic?

    Yes. Cheapflights offers flight deals from Des Moines to Czech Republic by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for Des Moines to Czech Republic

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