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$375+ Cheap flights from Des Moines (DSM) to the Czech Republic

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/30. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — PRG
Jan 21 — Jan 281
Wed 1/21
Wed 1/28
1 adult, Economy
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Cheap flight deals from Des Moines to Czech Republic

Cheapest flights from Des Moines to Czech Republic
Explore the most affordable flight options available from Des Moines to Czech Republic. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 22, 2025.

This Ovago deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/256:40 amDSM - PRG
2 stops21h 20mAer Lingus
Sat 12/2711:40 amPRG - DSM
2 stops19h 11mAer Lingus
Deal found 12/21$2,251
This Air Canada deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/2511:15 amDSM - PRG
3 stops18h 50mAir Canada
Sat 12/277:35 amPRG - DSM
3 stops21h 05mAir Canada
Deal found 12/21$2,542

Find flight deals from Des Moines to Czech Republic

Keep the following information in mind while searching for Des Moines to Czech Republic flight deals. Data was last updated December 22, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$484
(lol.travel)

One-way from

$375
(Kiwi.com)
Provider with most accurate pricing for Des Moines-Václav Havel Prague flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Václav Havel Prague flights.
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From Des Moines to Czech Republic
Search Deals
One-way flight from Des Moines to Czech Republic
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Czech Republic that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 22, 2025.
Use the filters below to find and compare flights from Des Moines to the Czech Republic that are best for you.

Fly from

Des Moines

Fly to

Czech Republic

Route

Depart

Return

Price

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Tue 2/3

6:48 pm-4:05 pm

2 stops38h 17m

Václav Havel Prague

Tue 2/10

6:15 am-9:50 pm

2 stops22h 35m

$484

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 2/11

11:30 am-1:05 pm

2 stops18h 35m

Václav Havel Prague

Thu 2/19

10:25 am-9:41 pm

2 stops18h 16m

$494

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 2/4

6:48 pm-4:05 pm

2 stops14h 17m

Václav Havel Prague

Wed 2/11

10:15 am-9:50 pm

2 stops18h 35m

$494

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Tue 2/3

12:06 pm-11:40 am

2 stops16h 34m

Václav Havel Prague

Tue 2/10

8:55 am-8:54 pm

2 stops18h 59m

$497

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 2/4

11:26 am-11:40 am

2 stops17h 14m

Václav Havel Prague

Wed 2/11

8:55 am-9:22 pm

2 stops19h 27m

$498

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Thu 2/5

5:05 am-6:50 pm

2 stops30h 45m

Václav Havel Prague

Thu 2/12

7:35 pm-11:38 pm

2 stops35h 03m

$499

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Fri 1/30

6:48 pm-10:25 pm

2 stops20h 37m

$375

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Fri 1/30

6:48 pm-12:10 am

3 stops22h 22m

$453

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/21

Best time to book a flight from Des Moines to Czech Republic

Have a flexible travel schedule? Discover the best time to fly to Czech Republic from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to the Czech Republic
No data available for this route at this time. Please check back soon.

Reviews of airlines servicing Czech Republic

Get insights into the airlines that provide service to Czech Republic. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Czech Republic. Reviews last updated December 22, 2025.
Read through reviews of airlines operating flights from Des Moines to the Czech Republic, such as United Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,102 reviews

Crew

8.1

Food

6.6

Overall

7.4

Comfort

7.3

Boarding

7.7

Entertainment

7.1

Reviews

1 / 20
10.0
Excellent

Michelle,Dec 2025

DEN - MKE

I liked that the plane waited 5 minutes for a family whose incoming plane was late. This was the last flight of the day to MKE. Flight attendants actually checked in throughout the flight. Although, not really friendly. Happy to see screens on seat backs again. This is my first time not flying first class in over 10 years. It was economy plus.
United Airlines
7.4
Good
9,102 reviews
United Airlines
7.4
Good
9,102 reviews

Crew

8.1

Food

6.6

Overall

7.4

Comfort

7.3

Boarding

7.7

Entertainment

7.1

Reviews

1 / 20
10.0
Excellent

Michelle,Dec 2025

DEN - MKE

I liked that the plane waited 5 minutes for a family whose incoming plane was late. This was the last flight of the day to MKE. Flight attendants actually checked in throughout the flight. Although, not really friendly. Happy to see screens on seat backs again. This is my first time not flying first class in over 10 years. It was economy plus.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Czech Republic. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Czech Republic?

    Most people fly from Des Moines (DSM) if they book a flight from Des Moines to Czech Republic. Des Moines is conveniently located just 3.6 mi from Des Moines’s city center.

  • How long is the flight from Des Moines to Czech Republic?

    For as low as $484, Lufthansa can have you in Czech Republic from Des Moines in 38h 17m. The distance from Des Moines to Czech Republic is about 4753 mi.

  • Can I find deals for flights from Des Moines to Czech Republic that include hotel bookings?

    Yes. In addition to deals on Des Moines to Czech Republic flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Czech Republic?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Czech Republic.

  • Can I find deals for business class flights from Des Moines to Czech Republic?

    Yes. Cheapflights offers flight deals from Des Moines to Czech Republic by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for Des Moines to Czech Republic

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Des Moines to Czech Republic

Discover the top airline that operate flights from Des Moines to Czech Republic. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 22, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$597Average$939FlexibilityNo cancel feeOn-time69%

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