Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Orlando to Cape Girardeau as you normally would.
Located just 6.3 mi from the city center, Cape Girardeau is the airport most travelers will use when flying to Cape Girardeau from Orlando. Booking flights from Orlando to Cape Girardeau (CGI) should be relatively easy as there are 0 daily inbound flights from Orlando from 0 different airlines.