HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Buffalo

$171+ Cheap flights from Panama City, FL to Buffalo (ECP - BUF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/4. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — BUF
Feb 28 — Mar 71
Sat 2/28
Sat 3/7
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Panama City to Buffalo with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Panama City to Buffalo

Cheapest flights from Panama City to Buffalo
Explore the most affordable flight options available from Panama City to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 29, 2026.

This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/21:58 pm
ECP
-
BUF
1 stop6h 26m
American Airlines
Tue 5/56:59 pm
BUF
-
ECP
1 stop4h 53m
American Airlines
Deal found 1/27$330
This Southwest deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/27:20 am
ECP
-
BUF
1 stop5h 55m
Southwest
Tue 5/511:10 am
BUF
-
ECP
2 stops8h 45m
Southwest
Deal found 1/27$335
This Delta deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/25:49 am
ECP
-
BUF
2 stops8h 25m
Delta
Tue 5/56:05 am
BUF
-
ECP
2 stops7h 36m
Delta
Deal found 1/27$352
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/54:34 pm
ECP
-
BUF
1 stop6h 16m
American Airlines
Thu 3/127:40 pm
BUF
-
ECP
1 stop5h 09m
American Airlines
Deal found 1/27$390
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/124:34 pm
ECP
-
BUF
1 stop6h 16m
American Airlines
Mon 2/167:41 pm
BUF
-
ECP
1 stop5h 08m
American Airlines
Deal found 1/27$467
This United Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/142:25 pm
ECP
-
BUF
1 stop5h 26m
United Airlines
Wed 2/187:00 am
BUF
-
ECP
2 stops10h 11m
United Airlines
Deal found 1/28$468
This Southwest deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/51:25 pm
ECP
-
BUF
2 stops9h 45m
Southwest
Thu 3/126:10 am
BUF
-
ECP
2 stops8h 05m
Southwest
Deal found 1/27$504
This Southwest deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/1212:35 pm
ECP
-
BUF
2 stops8h 35m
Southwest
Mon 2/165:25 am
BUF
-
ECP
2 stops12h 20m
Southwest
Deal found 1/27$573

Find flight deals from Panama City to Buffalo

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$330
(American Airlines)

One-way from

$171
(American Airlines)

Popular in

December

Cheapest in

September

Average price

$646
Provider with most accurate pricing for Panama City NW Florida Beaches-Buffalo flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City NW Florida Beaches-Buffalo flights.
Search Deals
From Panama City NW Florida Beaches to Buffalo
Search Deals
One-way flight from Panama City NW Florida Beaches to Buffalo
Search Deals
Highest demand for flights based on searches. 38% potential increase in price ($267 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 8% potential price decrease ($32 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Panama City to Buffalo that are best for you.

Fly from

Panama City

Fly to

Buffalo

Route

Depart

Return

Price

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Sat 5/2

7:20 am-2:15 pm

1 stop5h 55m

Buffalo

Tue 5/5

11:10 am-6:55 pm

2 stops8h 45m

$335

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Sat 5/2

5:49 am-3:14 pm

2 stops8h 25m

Buffalo

Tue 5/5

6:05 am-12:41 pm

2 stops7h 36m

$352

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Thu 3/5

4:34 pm-11:50 pm

1 stop6h 16m

Buffalo

Thu 3/12

7:40 pm-11:49 pm

1 stop5h 09m

$390

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Thu 2/12

4:34 pm-11:50 pm

1 stop6h 16m

Buffalo

Mon 2/16

7:41 pm-11:49 pm

1 stop5h 08m

$467

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Sat 2/14

2:25 pm-8:51 pm

1 stop5h 26m

Buffalo

Wed 2/18

7:00 am-4:11 pm

2 stops10h 11m

$468

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Thu 3/5

1:25 pm-12:10 am

2 stops9h 45m

Buffalo

Thu 3/12

6:10 am-1:15 pm

2 stops8h 05m

$504

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Thu 2/12

12:35 pm-10:10 pm

2 stops8h 35m

Buffalo

Mon 2/16

5:25 am-4:45 pm

2 stops12h 20m

$573

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Mon 5/4

7:21 am-1:04 pm

1 stop4h 43m

$171

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Sun 5/3

5:35 am-2:15 pm

2 stops7h 40m

$209

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Sat 2/14

6:00 am-1:03 pm

1 stop6h 03m

$234

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/27

Showing 1-10 of 11 results
1
2

Compare providers for flights from Panama City to Buffalo

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Buffalo in January.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City, Florida-Buffalo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City, Florida-Buffalo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City, Florida-Buffalo flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City, Florida-Buffalo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Buffalo

What is the cheapest month to book a flight from Panama City, Florida to Buffalo?

Currently, September is the cheapest month in which you can book a flight from Panama City, Florida to Buffalo (average of $203). Flying from Panama City, Florida to Buffalo in February is currently the most expensive (average of $299). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Buffalo

Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated January 29, 2026.
Read reviews from past customers who have flown Delta and American Airlines from Panama City to Buffalo. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,128 reviews

Overall

7.9

Food

7.2

Boarding

8.1

Comfort

7.9

Crew

8.5

Entertainment

7.8

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
Delta
7.9
Good
8,128 reviews
Delta
7.9
Good
8,128 reviews

Overall

7.9

Food

7.2

Boarding

8.1

Comfort

7.9

Crew

8.5

Entertainment

7.8

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
American Airlines
7.2
Good
11,205 reviews
Delta
7.9
Good
8,128 reviews

Overall

7.9

Food

7.2

Boarding

8.1

Comfort

7.9

Crew

8.5

Entertainment

7.8

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!

Related info for your journey

Find useful and relevant information for your journey from Panama City to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City, Florida to Buffalo?

    Southwest, Delta, and American Airlines can get you from Panama City, Florida to Buffalo in just under 5h 55m. Your travel time can differ by up to 2h 30m. Panama City, Florida and Buffalo are separated by a distance of 952 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Panama City, Florida to Buffalo round-trip?

    Flying on American Airlines is currently your cheapest option to Buffalo, with prices starting at $236. Another option worth looking into is Delta, starting at $296 round trip. You may be able to fly from Panama City, Florida to Buffalo for 44% less than the average price by searching for these airlines.

  • Can I find deals for flights from Panama City to Buffalo that include hotel bookings?

    Yes. In addition to deals on Panama City to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Buffalo.

  • Can I find deals for business class flights from Panama City to Buffalo?

    Yes. Cheapflights offers flight deals from Panama City to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to Buffalo?

    Currently, September is the cheapest month in which you can book a flight from Panama City, Florida to Buffalo (average of $203). Flying from Panama City, Florida to Buffalo in February is currently the most expensive (average of $299). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Lockport
Cheektowaga
Batavia
Williamsville
Orchard Park
Eden
Amherst
West Seneca

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Panama City to Buffalo

See prices for flight routes from nearby airports that may be better suited for you.
Fort Lauderdale to John F Kennedy Intl flights
Miami to John F Kennedy Intl flights
Fort Lauderdale to Newark flights
Fort Lauderdale to LaGuardia flights
Orlando to John F Kennedy Intl flights
Miami to LaGuardia flights
Miami to Newark flights
Tampa to John F Kennedy Intl flights
West Palm Beach to Newark flights
Tampa to LaGuardia flights
Orlando to Newark flights
Orlando to LaGuardia flights
Tampa to Newark flights
West Palm Beach to John F Kennedy Intl flights
West Palm Beach to LaGuardia flights
Jacksonville to John F Kennedy Intl flights
Jacksonville to Newark flights
Fort Myers to John F Kennedy Intl flights
Jacksonville to LaGuardia flights
Fort Myers to Newark flights
Orlando to White Plains flights
Fort Myers to LaGuardia flights
Sarasota to John F Kennedy Intl flights
Pensacola to LaGuardia flights
Orlando to Buffalo flights
Sarasota to Newark flights
Pensacola to John F Kennedy Intl flights
Fort Lauderdale to White Plains flights
Tampa to Islip flights
Sarasota to LaGuardia flights
Pensacola to Newark flights
Orlando to Albany flights
Tampa to White Plains flights
Daytona Beach to John F Kennedy Intl flights
Tampa to Buffalo flights
West Palm Beach to Islip flights
Orlando to Stewart flights
West Palm Beach to White Plains flights
Orlando to Islip flights
Gainesville to Newark flights
Orlando to Syracuse flights
Gainesville to John F Kennedy Intl flights
Panama City to LaGuardia flights
Fort Myers to White Plains flights
Fort Lauderdale to Stewart flights
Orlando to Rochester flights
Fort Lauderdale to Islip flights
Tallahassee to John F Kennedy Intl flights
Fort Lauderdale to Buffalo flights
Fort Lauderdale to Albany flights

Top 2 airlines flying from Panama City to Buffalo

Discover the top 2 airlines that operate flights from Panama City to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$236Average$367FlexibilityNo cancel feeOn-time71%
DeltaCheapest$296Average$356FlexibilityNo cancel feeOn-timeN/A

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.