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$168+ Cheap flights from Panama City, FL to Buffalo (ECP - BUF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/12. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — BUF
apr 17 — apr 241
ven 4/17
ven 4/24
1 adult, Economy
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Cheap flight deals from Panama City to Buffalo

Cheapest flights from Panama City to Buffalo
Explore the most affordable flight options available from Panama City to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on marzo 18, 2026.

This United Airlines deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar 5/52:14 pm
ECP
-
BUF
1 stop5h 47m
United Airlines
mer 5/67:00 am
BUF
-
ECP
1 stop7h 18m
United Airlines
Deal found 3/16$405
This Delta deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
gio 7/239:23 am
ECP
-
BUF
1 stop5h 07m
Delta
dom 7/266:16 am
BUF
-
ECP
1 stop5h 14m
Delta
Deal found 3/18$443
This Southwest deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
gio 7/237:50 am
ECP
-
BUF
1 stop6h 35m
Southwest
dom 7/267:20 am
BUF
-
ECP
1 stop7h 20m
Southwest
Deal found 3/17$447
This American Airlines deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
gio 7/231:17 pm
ECP
-
BUF
1 stop4h 55m
American Airlines
dom 7/267:34 pm
BUF
-
ECP
1 stop5h 03m
American Airlines
Deal found 3/17$453
This Delta deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ven 7/244:10 pm
ECP
-
BUF
1 stop6h 48m
Delta
dom 7/266:16 am
BUF
-
ECP
1 stop5h 14m
Delta
Deal found 3/16$461

Find flight deals from Panama City to Buffalo

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated marzo 18, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$405
(United Airlines)

One-way from

$168
(American Airlines)

Popular in

December

Cheapest in

September

Average price

$636
Provider with most accurate pricing for Panama City NW Florida Beaches-Buffalo flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City NW Florida Beaches-Buffalo flights.
Search Deals
From Panama City NW Florida Beaches to Buffalo
Search Deals
One-way flight from Panama City NW Florida Beaches to Buffalo
Search Deals
Highest demand for flights based on searches. 41% potential increase in price ($308 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 8% potential price decrease ($35 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated marzo 18, 2026.
Use the filters below to find and compare flights from Panama City to Buffalo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

mar 5/5

2:14 pm-9:01 pm

1 stop5h 47m

Buffalo

mer 5/6

7:00 am-1:18 pm

1 stop7h 18m

$405

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

gio 7/23

7:50 am-3:25 pm

1 stop6h 35m

Buffalo

dom 7/26

7:20 am-1:40 pm

1 stop7h 20m

$447

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

ven 7/24

4:10 pm-11:58 pm

1 stop6h 48m

Buffalo

dom 7/26

6:16 am-10:30 am

1 stop5h 14m

$461
Quickest round-trip

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

mer 4/22

5:10 pm-11:37 pm

1 stop5h 27m

Buffalo

gio 4/23

7:40 pm-11:12 pm

1 stop4h 32m

$478

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

ven 7/24

7:05 am-12:56 pm

1 stop4h 51m

Buffalo

dom 7/26

5:24 am-12:08 pm

1 stop7h 44m

$479
Cheapest one-way

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

mar 5/12

11:43 am-6:03 pm

1 stop5h 20m

$168

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

mer 5/13

12:05 pm-9:45 pm

2 stops8h 40m

$173

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

gio 4/23

10:48 am-6:38 pm

1 stop6h 50m

$183

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

gio 4/23

9:55 am-7:45 pm

2 stops8h 50m

$188

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

mer 4/8

2:19 pm-8:43 pm

1 stop5h 24m

$193

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/18

Showing 1-10 of 13 resultsSorted by cheapest first
1
2

Compare providers for flights from Panama City to Buffalo

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Buffalo in March.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City, Florida-Buffalo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City, Florida-Buffalo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City, Florida-Buffalo flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City, Florida-Buffalo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Buffalo

What is the cheapest month to book a flight from Panama City, Florida to Buffalo?

Currently, September is the cheapest month in which you can book a flight from Panama City, Florida to Buffalo (average of $203). Flying from Panama City, Florida to Buffalo in March is currently the most expensive (average of $359). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Buffalo

Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated marzo 18, 2026.
Read reviews from past customers who have flown Delta and American Airlines from Panama City to Buffalo. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,286 reviews

Boarding

8.1

Entertainment

7.8

Comfort

7.9

Crew

8.5

Food

7.2

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
Delta
7.9
Good
8,286 reviews
Delta
7.9
Good
8,286 reviews

Boarding

8.1

Entertainment

7.8

Comfort

7.9

Crew

8.5

Food

7.2

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
American Airlines
7.1
Good
11,468 reviews
Delta
7.9
Good
8,286 reviews

Boarding

8.1

Entertainment

7.8

Comfort

7.9

Crew

8.5

Food

7.2

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!

Related info for your journey

Find useful and relevant information for your journey from Panama City to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City, Florida to Buffalo?

    United Airlines and Delta can get you from Panama City, Florida to Buffalo in just under 5h 47m. Your travel time can differ by up to 1h 01m. Panama City, Florida and Buffalo are separated by a distance of 952 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Panama City, Florida to Buffalo round-trip?

    Flying on American Airlines is currently your cheapest option to Buffalo, with prices starting at $236. Another option worth looking into is Delta, starting at $296 round trip. You may be able to fly from Panama City, Florida to Buffalo for 46% less than the average price by searching for these airlines.

  • Can I find deals for flights from Panama City to Buffalo that include hotel bookings?

    Yes. In addition to deals on Panama City to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Buffalo.

  • Can I find deals for business class flights from Panama City to Buffalo?

    Yes. Cheapflights offers flight deals from Panama City to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to Buffalo?

    Currently, September is the cheapest month in which you can book a flight from Panama City, Florida to Buffalo (average of $203). Flying from Panama City, Florida to Buffalo in March is currently the most expensive (average of $359). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Lockport
Cheektowaga
Batavia
Williamsville
Orchard Park
Eden
Amherst
West Seneca

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Top 2 airlines flying from Panama City to Buffalo

Discover the top 2 airlines that operate flights from Panama City to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated marzo 18, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$236Average$387FlexibilityNo cancel feeOn-time71%
DeltaCheapest$296Average$334FlexibilityNo cancel feeOn-timeN/A

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