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$157+ Cheap flights from Panama City, FL to Buffalo (ECP - BUF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/9. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — BUF
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheap flight deals from Panama City to Buffalo

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 15, 2025.

Round-trip from

$287
(Delta)

One-way from

$157
(American Airlines)

Popular in

January

Cheapest in

September

Average price

$276
From Panama City NW Florida Beaches to Buffalo
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One-way flight from Panama City NW Florida Beaches to Buffalo
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Highest demand for flights based on searches. 14% potential increase in price ($67 potential increase over avg. RT price).
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Cheapest flight prices on average. 6% potential price decrease ($23 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Panama City to Buffalo

Cheapest flights from Panama City to Buffalo
Explore the most affordable flight options available from Panama City to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/276:00 amECP - BUF
1 stop4h 01mDelta
Sat 11/15:14 pmBUF - ECP
1 stop6h 56mDelta
Deal found 9/13$350
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/111:00 amECP - BUF
1 stop6h 03mDelta
Thu 10/26:00 amBUF - ECP
1 stop4h 55mDelta
Deal found 9/13$447
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/73:41 pmECP - BUF
1 stop7h 02mAmerican Airlines
Thu 10/96:00 amBUF - ECP
1 stop5h 13mAmerican Airlines
Deal found 9/14$507
This Southwest deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/17:40 amECP - BUF
2 stops9h 15mSouthwest
Thu 10/25:15 pmBUF - ECP
2 stops6h 20mSouthwest
Deal found 9/13$542
This Southwest deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/2711:05 amECP - BUF
2 stops11h 45mSouthwest
Sat 11/111:10 amBUF - ECP
2 stops6h 50mSouthwest
Deal found 9/13$551
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1810:13 amECP - BUF
1 stop7h 26mAmerican Airlines
Sun 9/211:42 pmBUF - ECP
1 stop5h 47mAmerican Airlines
Deal found 9/13$787

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Panama City to Buffalo that are best for you.

Fly from

Panama City

Fly to

Buffalo

Route

Depart

Return

Price

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Wed 2/18

6:00 am-11:16 am

1 stop4h 16m

Buffalo

Sat 2/21

2:00 pm-6:38 pm

1 stop5h 38m

$287

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Mon 10/27

6:00 am-11:01 am

1 stop4h 01m

Buffalo

Sat 11/1

5:14 pm-11:10 pm

1 stop6h 56m

$350

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Wed 2/18

2:57 pm-11:20 pm

2 stops7h 23m

Buffalo

Sat 2/21

6:23 am-9:54 am

1 stop4h 31m

$362

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Wed 10/1

11:00 am-6:03 pm

1 stop6h 03m

Buffalo

Thu 10/2

6:00 am-9:55 am

1 stop4h 55m

$447

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Tue 10/7

3:41 pm-11:43 pm

1 stop7h 02m

Buffalo

Thu 10/9

6:00 am-10:13 am

1 stop5h 13m

$507

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Thu 10/9

5:30 am-11:04 am

1 stop4h 34m

$157

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Thu 10/9

6:30 am-9:13 pm

3 stops13h 43m

$1,133

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/13

Best time to book a flight from Panama City to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Buffalo

What is the cheapest month to book a flight from Panama City, Florida to Buffalo?

Currently, January is the cheapest month in which you can book a flight from Panama City, Florida to Buffalo (average of $256). Flying from Panama City, Florida to Buffalo in December is currently the most expensive (average of $337). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ECP to BUF?

Find hourly flight availability from Panama City to Buffalo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 15, 2025.

A simple way to save on the total cost of your ticket is to fly from Panama City, Florida to Buffalo in the morning. If you’re flexible enough to do this you can expect to save up to 16% on your trip compared to booking a flight at noon.

Reviews of airlines servicing Buffalo

Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated September 15, 2025.
Read reviews from past customers who have flown Delta and American Airlines from Panama City to Buffalo. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,956 reviews

Comfort

7.9

Crew

8.5

Entertainment

7.9

Food

7.3

Boarding

8.2

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
Delta
8.0
Very good
7,956 reviews
Delta
8.0
Very good
7,956 reviews

Comfort

7.9

Crew

8.5

Entertainment

7.9

Food

7.3

Boarding

8.2

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,956 reviews

Comfort

7.9

Crew

8.5

Entertainment

7.9

Food

7.3

Boarding

8.2

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!

Related info for your journey

Find useful and relevant information for your journey from Panama City to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City, Florida to Buffalo?

    Delta can get you from Panama City, Florida to Buffalo in just under 4h 16m. Your travel time can differ by up to . Panama City, Florida and Buffalo are separated by a distance of 952 mi.

  • What are the cheapest airlines flying from Panama City, Florida to Buffalo round-trip?

    Flying on American Airlines is currently your cheapest option to Buffalo, with prices starting at $172. Another option worth looking into is Delta, starting at $290 round trip. You may be able to fly from Panama City, Florida to Buffalo for 57% less than the average price by searching for these airlines.

  • Can I find deals for flights from Panama City to Buffalo that include hotel bookings?

    Yes. In addition to deals on Panama City to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Buffalo.

  • Can I find deals for business class flights from Panama City to Buffalo?

    Yes. Cheapflights offers flight deals from Panama City to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to Buffalo?

    Currently, January is the cheapest month in which you can book a flight from Panama City, Florida to Buffalo (average of $256). Flying from Panama City, Florida to Buffalo in December is currently the most expensive (average of $337). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Lockport
Orchard Park
Batavia
Williamsville
Eden
Amherst
West Seneca

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Top 2 airlines flying from Panama City to Buffalo

Discover the top 2 airlines that operate flights from Panama City to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$172Average$318FlexibilityNo cancel feeOn-time71%
DeltaCheapest$290Average$366FlexibilityNo cancel feeOn-timeN/A

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