$141+ Cheap flights from Missouri to Buffalo (BUF)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/15. Fares are subject to change and may not be available on all flights or dates of travel.
STL — BUF
Dec 3 — Dec 101
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Missouri to Buffalo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Missouri to Buffalo
Cheapest
Best
Last-minute
One-way
Cheapest flights from Missouri to BuffaloExplore the most affordable flight options available from Missouri to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 3, 2026.
Explore the most affordable flight options available from Missouri to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 3, 2026.
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/197:00 am -
1 stop5h 26m
Mon 11/236:36 pm -
1 stop6h 20m
Deal found 10/29![Delta logo]()
$271
This CheapOair deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/186:20 pm -
1 stop25h 23m
Sun 12/206:20 pm -
1 stop7h 21m
Deal found 11/2![Frontier logo]()
$275
This Frontier deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2011:11 am -
1 stop8h 13m
Sun 11/229:20 pm -
1 stop13h 56m
Deal found 10/29![Frontier logo]()
$280
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/94:05 pm -
1 stop4h 55m
Mon 12/142:00 pm -
1 stop5h 50m
Deal found 10/29![Southwest logo]()
$281
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/107:20 am -
1 stop6h 55m
Sat 1/92:20 pm -
1 stop6h 20m
Deal found 10/29![Southwest logo]()
$298
This Delta deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/97:00 am -
1 stop5h 29m
Fri 12/119:15 am -
1 stop5h 15m
Deal found 10/30![Delta logo]()
$309
This Southwest deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/97:20 am -
1 stop6h 55m
Fri 12/119:05 am -
2 stops11h 05m
Deal found 10/30![Southwest logo]()
$310
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/196:20 am -
1 stop3h 20m
Mon 11/2311:00 am -
2 stops9h 10m
Deal found 10/29![Southwest logo]()
$325
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/116:03 am -
1 stop8h 06m
Sun 12/136:49 pm -
1 stop6h 47m
Deal found 11/2![American Airlines logo]()
$363
This Southwest deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/115:35 am -
1 stop3h 50m
Sun 12/135:30 pm -
2 stops6h 30m
Deal found 11/2![Southwest logo]()
$368
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/245:30 am -
1 stop3h 35m
Fri 11/275:30 pm -
1 stop7h 40m
Deal found 10/29![Southwest logo]()
$371
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/301:08 pm -
1 stop6h 28m
Thu 12/311:30 am -
1 stop5h 54m
Deal found 11/1![United Airlines logo]()
$373
Best flights from Missouri to BuffaloDiscover carefully curated flight deals from Missouri to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 3, 2026.
Discover carefully curated flight deals from Missouri to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 3, 2026.
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/94:05 pm -
1 stop4h 55m
Mon 12/142:00 pm -
1 stop5h 50m
Deal found 10/29![Southwest logo]()
$281
This Delta deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/1810:13 am -
1 stop6h 41m
Thu 1/216:05 am -
1 stop5h 59m
Deal found 10/30![Delta logo]()
$309
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/611:36 am -
1 stop4h 15m
Sat 1/96:30 am -
1 stop5h 16m
Deal found 10/29![United Airlines logo]()
$370
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/107:20 am -
1 stop6h 55m
Sat 1/92:20 pm -
1 stop6h 20m
Deal found 10/29![Southwest logo]()
$298
This Southwest deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/911:55 am -
2 stops9h 05m
Fri 12/119:05 am -
2 stops11h 05m
Deal found 10/30![Southwest logo]()
$315
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/63:12 pm -
1 stop4h 39m
Sat 1/910:15 am -
1 stop5h 19m
Deal found 11/1![United Airlines logo]()
$391
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/196:20 am -
1 stop3h 20m
Mon 11/2311:00 am -
2 stops9h 10m
Deal found 10/29![Southwest logo]()
$325
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/129:40 am -
1 stop6h 17m
Wed 12/1610:30 am -
1 stop5h 11m
Deal found 11/1![United Airlines logo]()
$404
This United Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/185:00 am -
2 stops10h 41m
Thu 1/215:43 pm -
1 stop4h 54m
Deal found 10/31![United Airlines logo]()
$414
This Southwest deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/305:30 am -
1 stop3h 35m
Thu 12/33:55 pm -
2 stops7h 05m
Deal found 11/1![Southwest logo]()
$408
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/69:47 am -
1 stop6h 04m
Sat 1/910:15 am -
1 stop5h 02m
Deal found 10/29![United Airlines logo]()
$420
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/57:36 am -
1 stop4h 41m
Wed 12/96:30 am -
1 stop4h 57m
Deal found 11/2![United Airlines logo]()
$425
This Southwest deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/196:20 pm -
1 stop4h 55m
Sat 12/267:35 pm -
1 stop4h 35m
Deal found 11/2![Southwest logo]()
$446
This United Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/273:10 pm -
1 stop5h 11m
Wed 3/35:50 pm -
1 stop4h 40m
Deal found 10/31![United Airlines logo]()
$428
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/193:17 pm -
1 stop4h 18m
Sat 12/267:52 pm -
1 stop5h 07m
Deal found 11/2![United Airlines logo]()
$430
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2612:55 pm -
1 stop5h 09m
Fri 11/276:30 am -
1 stop6h 53m
Deal found 11/2![United Airlines logo]()
$440
This United Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/296:00 am -
2 stops7h 15m
Tue 1/55:43 pm -
1 stop5h 03m
Deal found 10/31![United Airlines logo]()
$536
Last-minute flights from Missouri to BuffaloDiscover last-minute flight deals from Missouri to Buffalo. Data last updated November 3, 2026 and is based on user searches.
Discover last-minute flight deals from Missouri to Buffalo. Data last updated November 3, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/303:10 pm -
1 stop4h 26m
Tue 11/310:30 am -
1 stop5h 03m
Deal found 10/29![United Airlines logo]()
$409
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/305:08 pm -
1 stop5h 51m
Tue 11/36:45 pm -
1 stop4h 55m
Deal found 10/29![American Airlines logo]()
$418
This Delta deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/316:00 am -
2 stops8h 11m
Sun 11/112:15 pm -
2 stops10h 04m
Deal found 10/30![Delta logo]()
$419
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/181:08 pm -
1 stop6h 28m
Thu 11/196:00 am -
1 stop5h 48m
Deal found 10/29![United Airlines logo]()
$389
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/197:00 am -
1 stop5h 26m
Mon 11/236:36 pm -
1 stop6h 20m
Deal found 10/29![Delta logo]()
$271
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/196:20 am -
1 stop3h 20m
Mon 11/2311:00 am -
2 stops9h 10m
Deal found 10/29![Southwest logo]()
$325
This Mytrip deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/197:24 pm -
2 stops24h 00m
Sun 11/229:20 pm -
2 stops21h 20m
Deal found 10/30![Frontier logo]()
$388
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/195:00 am -
1 stop4h 45m
Mon 11/235:28 am -
1 stop5h 40m
Deal found 11/2![American Airlines logo]()
$413
This Frontier deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2011:11 am -
1 stop8h 13m
Sun 11/229:20 pm -
1 stop13h 56m
Deal found 10/29![Frontier logo]()
$280
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/245:30 am -
1 stop3h 35m
Fri 11/275:30 pm -
1 stop7h 40m
Deal found 10/29![Southwest logo]()
$371
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/301:08 pm -
1 stop6h 28m
Thu 12/311:30 am -
1 stop5h 54m
Deal found 11/1![United Airlines logo]()
$373
This Southwest deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/305:30 am -
1 stop3h 35m
Thu 12/33:55 pm -
2 stops7h 05m
Deal found 11/1![Southwest logo]()
$408
One-way flights from Missouri to BuffaloSearch for one-way flight options from Missouri to Buffalo. Find affordable one-way fares based on user searches. Data last updated November 3, 2026.
Search for one-way flight options from Missouri to Buffalo. Find affordable one-way fares based on user searches. Data last updated November 3, 2026.
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/156:45 am -
1 stop5h 44m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/29![Delta logo]()
$141
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/266:00 am -
2 stops12h 04m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/29![United Airlines logo]()
$146
This Kiwi.com deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/27:58 pm -
2 stops39h 21m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/31![Frontier logo]()
$152
This Southwest deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/23:35 pm -
1 stop5h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/31![Southwest logo]()
$155
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/235:31 pm -
1 stop5h 28m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/2![Delta logo]()
$163
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/236:00 am -
2 stops7h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/2![United Airlines logo]()
$168
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2610:25 am -
1 stop5h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/2![American Airlines logo]()
$170
This Southwest deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/48:20 am -
2 stops6h 05m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/2![Southwest logo]()
$195
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/37:31 am -
1 stop4h 32m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/1![United Airlines logo]()
$219
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/271:45 pm -
1 stop7h 01m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/2![American Airlines logo]()
$231
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/301:45 pm -
1 stop7h 01m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/2![American Airlines logo]()
$284
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/11:45 pm -
2 stops9h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/2![American Airlines logo]()
$289
Find flight deals from Missouri to Buffalo
Keep the following information in mind while searching for Missouri to Buffalo flight deals. Data was last updated November 3, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $271 (Delta) |
One-way from | $141 (Delta) |
Popular in | April |
Cheapest in | February |
Average price | $467 |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 3, 2026.
Use the filters below to find and compare flights from Missouri to Buffalo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Kansas CityBuffalo
MCI Kansas City - BUF Buffalo
MCIBUF
Kansas City
Tue 12/15
6:45 am-1:29 pm
1 stop5h 44m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$141
Kansas CityBuffalo
MCI Kansas City - BUF Buffalo
MCIBUF
Kansas City
Thu 11/26
12:55 pm-7:04 pm
1 stop5h 09m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$141
Quickest round-trip
Kansas CityBuffalo
MCI Kansas City - BUF Buffalo
MCIBUF
Kansas City
Tue 12/15
6:00 am-10:40 am
1 stop3h 40m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$141
Kansas CityBuffalo
MCI Kansas City - BUF Buffalo
MCIBUF
Kansas City
Tue 12/15
1:04 pm-11:34 pm
2 stops9h 30m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$146
St. LouisBuffalo
STL Lambert-St Louis - BUF Buffalo
STLBUF
Lambert-St Louis
Wed 12/2
7:58 pm-12:19 pm
2 stops39h 21m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$152
Kansas CityBuffalo
MCI Kansas City - BUF Buffalo
MCIBUF
Kansas City
Fri 12/25
4:05 pm-10:00 pm
1 stop4h 55m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$163
Kansas CityBuffalo
MCI Kansas City - BUF Buffalo
MCIBUF
Kansas City
Mon 1/4
5:26 pm-11:59 pm
1 stop5h 33m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$163
Kansas CityBuffalo
MCI Kansas City - BUF Buffalo
MCIBUF
Kansas City
Mon 11/23
5:31 pm-11:59 pm
1 stop5h 28m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$163
Kansas CityBuffalo
MCI Kansas City - BUF Buffalo
MCIBUF
Kansas City
Mon 11/23
6:00 am-2:20 pm
2 stops7h 20m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$168
SpringfieldBuffalo
SGF Springfield-Branson - BUF Buffalo
SGFBUF
Springfield-Branson
Thu 11/26
10:25 am-4:25 pm
1 stop5h 00m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$170
Showing 1-10 of 38 resultsSorted by cheapest first
Best time to book a flight from Missouri to Buffalo
Have a flexible travel schedule? Discover the best time to fly to Buffalo from Missouri with our price prediction graph.
STL-BUF
MCI-BUF
COU-BUF
SGF-BUF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to Buffalo
USMO-BUF
STL-BUF
MCI-BUF
COU-BUF
SGF-BUF
What is the cheapest month to book a flight from Missouri to Buffalo?
Currently, February is the cheapest month in which you can book a flight from Missouri to Buffalo (average of $337). Flying from Missouri to Buffalo in April is currently the most expensive (average of $466). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Missouri to Buffalo?
Airfare is below average for this route at the moment.
Missouri to Buffalo flights typically cost between $337 and $621 in November.The cheapest round-trip price found within the last 5 days was $271 on Delta (Nov 19-Nov 23).
Related info for your journey
Find useful and relevant information for your journey from Missouri to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Buffalo?
Book flights to Buffalo if you plan to visit one of these locationsCheektowaga
Lockport
Amherst
Williamsville
Orchard Park
Eden
Bowmansville
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Buffalo flight routes
Complete your trip
Flights by cabin class
Other flight options
Popular flights
Top destinations
Alternative routes for Missouri to Buffalo
See prices for flight routes from nearby airports that may be better suited for you.
Other flights to Buffalo
Explore flights to Buffalo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on November 3, 2026.
Complete your trip
Complete your trip to Buffalo by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Missouri to Buffalo by cabin class
Find flights from Missouri to Buffalo, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Missouri and Buffalo flights
Browse other Missouri and Buffalo flight options. Last updated on November 3, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Missouri to Buffalo flights
Consider these flights traveling from Missouri to Buffalo.
Top 5 airlines flying from Missouri to Buffalo
Discover the top 5 airlines that operate flights from Missouri to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 3, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$115 | Average$126 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$145 | Average$432 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$233 | Average$403 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$248 | Average$428 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$298 | Average$421 | FlexibilityNo cancel fee | On-time63% |