$92+ Cheap flights from Missouri to Buffalo (BUF)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/15. Fares are subject to change and may not be available on all flights or dates of travel.
STL — BUF
Apr 29 — May 61
Round-trip
1 adult, Economy
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Cheapest flights from Missouri to BuffaloExplore the most affordable flight options available from Missouri to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 30, 2026.
Explore the most affordable flight options available from Missouri to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 30, 2026.
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/411:13 am
MCI
- BUF
1 stop22h 28m
Frontier
Sat 5/912:41 pm
BUF
- MCI
1 stop5h 48m
Frontier
Deal found 3/25![Frontier logo]()
$146
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/66:24 pm
MCI
- BUF
1 stop15h 17m
Frontier
Fri 5/82:49 pm
BUF
- MCI
1 stop27h 40m
Frontier
Deal found 3/25![Frontier logo]()
$149
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/111:19 am
MCI
- BUF
1 stop23h 54m
Frontier
Fri 5/82:49 pm
BUF
- MCI
1 stop27h 40m
Frontier
Deal found 3/25![Frontier logo]()
$159
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/52:34 pm
MCI
- BUF
2 stops22h 20m
Frontier
Sat 5/912:41 pm
BUF
- MCI
1 stop5h 48m
Frontier
Deal found 3/25![Frontier logo]()
$193
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/42:15 pm
MCI
- BUF
2 stops19h 26m
Frontier
Fri 5/82:49 pm
BUF
- MCI
1 stop27h 40m
Frontier
Deal found 3/25![Frontier logo]()
$194
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/66:24 pm
MCI
- BUF
2 stops24h 40m
Frontier
Sat 5/912:41 pm
BUF
- MCI
1 stop5h 48m
Frontier
Deal found 3/25![Frontier logo]()
$196
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/411:13 am
MCI
- BUF
1 stop22h 28m
Multiple Airlines
Wed 5/62:49 pm
BUF
- MCI
2 stops18h 05m
Multiple Airlines
Deal found 3/25![Multiple Airlines logo]()
$197
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/111:19 am
MCI
- BUF
1 stop23h 54m
Multiple Airlines
Wed 5/62:49 pm
BUF
- MCI
2 stops18h 05m
Multiple Airlines
Deal found 3/25![Multiple Airlines logo]()
$207
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/115:27 pm
STL
- BUF
1 stop16h 14m
Frontier
Mon 5/182:49 pm
BUF
- STL
1 stop27h 44m
Frontier
Deal found 3/27![Frontier logo]()
$208
This Kiwi.com deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/3011:21 am
STL
- BUF
1 stop23h 02m
Frontier
Sun 5/312:32 pm
BUF
- STL
1 stop19h 18m
Frontier
Deal found 3/26![Frontier logo]()
$224
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/111:19 am
MCI
- BUF
1 stop23h 54m
Frontier
Tue 5/1211:36 am
BUF
- MCI
2 stops27h 13m
Frontier
Deal found 3/25![Frontier logo]()
$226
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/311:53 am
MCI
- BUF
2 stops21h 41m
Frontier
Fri 5/82:49 pm
BUF
- MCI
1 stop27h 40m
Frontier
Deal found 3/25![Frontier logo]()
$228
Best flights from Missouri to BuffaloDiscover carefully curated flight deals from Missouri to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 30, 2026.
Discover carefully curated flight deals from Missouri to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 30, 2026.
This Delta deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/55:46 pm
MCI
- BUF
1 stop3h 53m
Delta
Sat 5/96:25 am
BUF
- MCI
1 stop4h 21m
Delta
Deal found 3/25![Delta logo]()
$315
This United Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/141:33 pm
SGF
- BUF
1 stop8h 37m
United Airlines
Sat 4/187:00 am
BUF
- SGF
1 stop4h 48m
United Airlines
Deal found 3/30![United Airlines logo]()
$339
This Southwest deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/2012:50 pm
STL
- BUF
1 stop4h 25m
Southwest
Wed 6/244:25 pm
BUF
- STL
2 stops7h 00m
Southwest
Deal found 3/27![Southwest logo]()
$381
This Kiwi.com deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/36:19 pm
MCI
- BUF
1 stop15h 21m
Frontier
Fri 8/72:50 pm
BUF
- MCI
2 stops23h 10m
Frontier
Deal found 3/30![Frontier logo]()
$383
This American Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/229:22 am
STL
- BUF
1 stop7h 19m
American Airlines
Sun 7/265:25 pm
BUF
- STL
1 stop5h 02m
American Airlines
Deal found 3/30![American Airlines logo]()
$392
This Delta deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/52:10 pm
MCI
- BUF
1 stop3h 41m
Delta
Sun 5/109:00 am
BUF
- MCI
1 stop5h 18m
Delta
Deal found 3/25![Delta logo]()
$364
This United Airlines deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/511:15 am
STL
- BUF
2 stops11h 40m
United Airlines
Wed 5/65:50 pm
BUF
- STL
1 stop4h 23m
United Airlines
Deal found 3/28![United Airlines logo]()
$382
This Southwest deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/56:05 pm
MCI
- BUF
1 stop5h 05m
Southwest
Mon 6/87:55 pm
BUF
- MCI
1 stop4h 20m
Southwest
Deal found 3/28![Southwest logo]()
$386
This Delta deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/36:30 am
MCI
- BUF
1 stop4h 09m
Delta
Wed 5/66:05 am
BUF
- MCI
1 stop4h 44m
Delta
Deal found 3/25![Delta logo]()
$364
This American Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/1010:21 am
SGF
- BUF
1 stop6h 09m
American Airlines
Tue 4/1411:31 am
BUF
- SGF
1 stop7h 04m
American Airlines
Deal found 3/26![American Airlines logo]()
$421
This Southwest deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/217:45 pm
STL
- BUF
1 stop11h 05m
Southwest
Mon 5/258:00 pm
BUF
- STL
1 stop3h 45m
Southwest
Deal found 3/29![Southwest logo]()
$392
This United Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/283:23 pm
COU
- BUF
1 stop4h 20m
United Airlines
Sat 5/27:00 am
BUF
- COU
1 stop4h 55m
United Airlines
Deal found 3/26![United Airlines logo]()
$398
This Southwest deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/308:10 pm
STL
- BUF
1 stop11h 00m
Southwest
Sun 8/23:25 pm
BUF
- STL
1 stop8h 10m
Southwest
Deal found 3/30![Southwest logo]()
$392
This Southwest deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/174:00 pm
STL
- BUF
1 stop6h 20m
Southwest
Mon 4/208:00 pm
BUF
- STL
1 stop3h 45m
Southwest
Deal found 3/29![Southwest logo]()
$394
This United Airlines deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/23:22 pm
MCI
- BUF
1 stop4h 39m
United Airlines
Wed 5/611:02 am
BUF
- MCI
1 stop6h 22m
United Airlines
Deal found 3/27![United Airlines logo]()
$437
This American Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/162:11 pm
SGF
- BUF
1 stop7h 19m
American Airlines
Mon 7/2010:02 am
BUF
- SGF
1 stop4h 39m
American Airlines
Deal found 3/26![American Airlines logo]()
$503
This United Airlines deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/126:17 am
MCI
- BUF
2 stops6h 53m
United Airlines
Sat 5/165:55 pm
BUF
- MCI
1 stop5h 13m
United Airlines
Deal found 3/28![United Airlines logo]()
$442
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/198:40 am
MCI
- BUF
1 stop4h 55m
Southwest
Thu 7/238:45 am
BUF
- MCI
1 stop6h 30m
Southwest
Deal found 3/26![Southwest logo]()
$407
This American Airlines deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/2611:27 am
SGF
- BUF
1 stop6h 14m
American Airlines
Wed 7/16:00 am
BUF
- SGF
1 stop5h 00m
American Airlines
Deal found 3/27![American Airlines logo]()
$518
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/302:25 pm
STL
- BUF
2 stops7h 55m
Southwest
Sun 5/32:55 pm
BUF
- STL
2 stops6h 40m
Southwest
Deal found 3/26![Southwest logo]()
$437
This United Airlines deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/113:10 pm
SGF
- BUF
1 stop4h 39m
United Airlines
Sun 4/126:09 am
BUF
- SGF
2 stops9h 26m
United Airlines
Deal found 3/29![United Airlines logo]()
$522
This United Airlines deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/1111:23 am
SGF
- BUF
2 stops11h 11m
United Airlines
Thu 4/167:00 am
BUF
- SGF
1 stop4h 48m
United Airlines
Deal found 3/29![United Airlines logo]()
$528
Last-minute flights from Missouri to BuffaloDiscover last-minute flight deals from Missouri to Buffalo. Data last updated March 30, 2026 and is based on user searches.
Discover last-minute flight deals from Missouri to Buffalo. Data last updated March 30, 2026 and is based on user searches.
This Expedia deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/307:47 am
STL
- BUF
1 stop11h 43m
Frontier
Fri 4/39:00 pm
BUF
- STL
1 stop11h 51m
Frontier
Deal found 3/26![Frontier logo]()
$240
This Delta deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/73:56 pm
SGF
- BUF
1 stop6h 50m
Delta
Sun 4/124:42 pm
BUF
- SGF
1 stop6h 01m
Delta
Deal found 3/29![Delta logo]()
$384
This Delta deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/73:56 pm
SGF
- BUF
1 stop6h 50m
Delta
Sat 4/116:00 am
BUF
- SGF
1 stop6h 07m
Delta
Deal found 3/29![Delta logo]()
$388
This Trip.com deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/84:59 pm
STL
- BUF
1 stop17h 03m
Frontier
Sun 4/1211:57 am
BUF
- STL
1 stop20h 54m
Frontier
Deal found 3/30![Frontier logo]()
$245
This Kiwi.com deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/96:29 pm
STL
- BUF
1 stop16h 48m
Frontier
Sun 4/128:59 pm
BUF
- STL
1 stop11h 52m
Frontier
Deal found 3/26![Frontier logo]()
$388
This Expedia deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/104:59 pm
STL
- BUF
1 stop17h 00m
Frontier
Sun 4/128:59 pm
BUF
- STL
1 stop11h 52m
Frontier
Deal found 3/27![Frontier logo]()
$280
This United Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/141:33 pm
SGF
- BUF
1 stop8h 37m
United Airlines
Sat 4/187:00 am
BUF
- SGF
1 stop4h 48m
United Airlines
Deal found 3/30![United Airlines logo]()
$339
This Kiwi.com deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/2311:25 am
STL
- BUF
1 stop22h 58m
Frontier
Thu 4/301:08 pm
BUF
- STL
1 stop18h 42m
Frontier
Deal found 3/26![Frontier logo]()
$246
This Kiwi.com deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/2711:13 am
MCI
- BUF
1 stop24h 29m
Frontier
Mon 5/412:32 pm
BUF
- MCI
2 stops50h 17m
Frontier
Deal found 3/28![Frontier logo]()
$300
This Southwest deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/275:30 am
MCI
- BUF
1 stop3h 45m
Southwest
Mon 5/46:00 am
BUF
- MCI
1 stop4h 20m
Southwest
Deal found 3/28![Southwest logo]()
$365
This American Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/294:51 pm
MCI
- BUF
1 stop5h 28m
American Airlines
Sun 5/36:00 am
BUF
- MCI
1 stop5h 18m
American Airlines
Deal found 3/30![American Airlines logo]()
$382
This Kiwi.com deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/3011:21 am
STL
- BUF
1 stop23h 02m
Frontier
Sun 5/312:32 pm
BUF
- STL
1 stop19h 18m
Frontier
Deal found 3/26![Frontier logo]()
$224
One-way flights from Missouri to BuffaloSearch for one-way flight options from Missouri to Buffalo. Find affordable one-way fares based on user searches. Data last updated March 30, 2026.
Search for one-way flight options from Missouri to Buffalo. Find affordable one-way fares based on user searches. Data last updated March 30, 2026.
This Trip.com deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/158:23 pm
STL
- BUF
1 stop14h 17m
Frontier
Deal found 3/26![Frontier logo]()
$92
This Delta deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/266:04 pm
STL
- BUF
1 stop4h 55m
Delta
Deal found 3/26![Delta logo]()
$129
This Kiwi.com deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/268:08 pm
STL
- BUF
2 stops37h 33m
Frontier
Deal found 3/26![Frontier logo]()
$132
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/295:27 pm
STL
- BUF
1 stop17h 01m
Frontier
Deal found 3/27![Frontier logo]()
$139
This Trip.com deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/136:24 pm
MCI
- BUF
1 stop15h 17m
Frontier
Deal found 3/29![Frontier logo]()
$140
This Kiwi.com deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/12:34 pm
MCI
- BUF
2 stops19h 07m
Frontier
Deal found 3/30![Frontier logo]()
$141
This Kiwi.com deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/264:59 pm
STL
- BUF
2 stops17h 48m
Frontier
Deal found 3/29![Frontier logo]()
$147
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/155:35 am
STL
- BUF
1 stop3h 45m
Southwest
Deal found 3/26![Southwest logo]()
$150
This United Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/159:10 am
STL
- BUF
2 stops8h 39m
United Airlines
Deal found 3/26![United Airlines logo]()
$168
This Kiwi.com deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/108:08 pm
STL
- BUF
2 stops16h 46m
Frontier
Deal found 3/26![Frontier logo]()
$169
This Delta deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/155:46 pm
MCI
- BUF
1 stop3h 53m
Delta
Deal found 3/26![Delta logo]()
$170
This Southwest deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/116:30 am
STL
- BUF
2 stops6h 50m
Southwest
Deal found 3/28![Southwest logo]()
$174
Find flight deals from Missouri to Buffalo
Keep the following information in mind while searching for Missouri to Buffalo flight deals. Data was last updated March 30, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $146 (Kiwi.com) |
One-way from | $92 (Trip.com) |
Popular in | March |
Cheapest in | July |
Average price | $466 |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 30, 2026.
Use the filters below to find and compare flights from Missouri to Buffalo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Kansas CityBuffalo
MCI - BUF
MCIBUF
Kansas City
Tue 5/5
5:46 pm-10:39 pm
1 stop3h 53m
Buffalo
Sat 5/9
6:25 am-9:46 am
1 stop4h 21m
$315
SpringfieldBuffalo
SGF - BUF
SGFBUF
Springfield-Branson
Tue 4/14
1:33 pm-11:10 pm
1 stop8h 37m
Buffalo
Sat 4/18
7:00 am-10:48 am
1 stop4h 48m
$339
Kansas CityBuffalo
MCI - BUF
MCIBUF
Kansas City
Tue 5/5
2:10 pm-6:51 pm
1 stop3h 41m
Buffalo
Sun 5/10
9:00 am-1:18 pm
1 stop5h 18m
$364
Kansas CityBuffalo
MCI - BUF
MCIBUF
Kansas City
Sun 5/3
6:30 am-11:39 am
1 stop4h 09m
Buffalo
Wed 5/6
6:05 am-9:49 am
1 stop4h 44m
$364
St. LouisBuffalo
STL - BUF
STLBUF
Lambert-St Louis
Sat 6/20
12:50 pm-6:15 pm
1 stop4h 25m
Buffalo
Wed 6/24
4:25 pm-10:25 pm
2 stops7h 00m
$381
St. LouisBuffalo
STL - BUF
STLBUF
Lambert-St Louis
Tue 5/5
11:15 am-11:55 pm
2 stops11h 40m
Buffalo
Wed 5/6
5:50 pm-9:13 pm
1 stop4h 23m
$382
Kansas CityBuffalo
MCI - BUF
MCIBUF
Kansas City
Mon 8/3
6:19 pm-10:40 am
1 stop15h 21m
Buffalo
Fri 8/7
2:50 pm-1:00 pm
2 stops23h 10m
$383
Kansas CityBuffalo
MCI - BUF
MCIBUF
Kansas City
Fri 6/5
6:05 pm-12:10 am
1 stop5h 05m
Buffalo
Mon 6/8
7:55 pm-11:15 pm
1 stop4h 20m
$386
St. LouisBuffalo
STL - BUF
STLBUF
Lambert-St Louis
Wed 7/22
9:22 am-5:41 pm
1 stop7h 19m
Buffalo
Sun 7/26
5:25 pm-9:27 pm
1 stop5h 02m
$392
St. LouisBuffalo
STL - BUF
STLBUF
Lambert-St Louis
Thu 5/21
7:45 pm-7:50 am
1 stop11h 05m
Buffalo
Mon 5/25
8:00 pm-10:45 pm
1 stop3h 45m
$392
Showing 1-10 of 49 resultsSorted by cheapest first
Best time to book a flight from Missouri to Buffalo
Have a flexible travel schedule? Discover the best time to fly to Buffalo from Missouri with our price prediction graph.
MCI-BUF
SGF-BUF
STL-BUF
COU-BUF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to Buffalo
USMO-BUF
MCI-BUF
SGF-BUF
STL-BUF
COU-BUF
What is the cheapest month to book a flight from Missouri to Buffalo?
Currently, September is the cheapest month in which you can book a flight from Missouri to Buffalo (average of $175). Flying from Missouri to Buffalo in March is currently the most expensive (average of $316). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Missouri to Buffalo?
Related info for your journey
Find useful and relevant information for your journey from Missouri to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Buffalo?
Book flights to Buffalo if you plan to visit one of these locationsLockport
Cheektowaga
Batavia
Williamsville
Orchard Park
Eden
Amherst
West Seneca
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Buffalo flight routes
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Alternative routes for Missouri to Buffalo
See prices for flight routes from nearby airports that may be better suited for you.
Other flights to Buffalo
Explore flights to Buffalo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on March 30, 2026.
Complete your trip
Complete your trip to Buffalo by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Missouri to Buffalo by cabin class
Find flights from Missouri to Buffalo, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Missouri and Buffalo flights
Browse other Missouri and Buffalo flight options. Last updated on March 30, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Missouri to Buffalo flights
Consider these flights traveling from Missouri to Buffalo.
Top 4 airlines flying from Missouri to Buffalo
Discover the top 4 airlines that operate flights from Missouri to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 30, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$167 | Average$453 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$221 | Average$349 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$233 | Average$312 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$291 | Average$461 | FlexibilityNo cancel fee | On-time63% |