$77+ Cheap flights from Missouri to Buffalo (BUF)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/23. Fares are subject to change and may not be available on all flights or dates of travel.
STL — BUF
Oct 18 — Oct 251
Round-trip
1 adult, Economy
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Find cheap flights from Missouri to Buffalo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Missouri to BuffaloExplore the most affordable flight options available from Missouri to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 18, 2026.
Explore the most affordable flight options available from Missouri to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 18, 2026.
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:00 am -
1 stop5h 46m
Wed 10/218:00 am -
1 stop5h 35m
Deal found 9/16![American Airlines logo]()
$227
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/142:20 pm -
2 stops7h 05m
Wed 10/218:00 am -
1 stop4h 35m
Deal found 9/16![Southwest logo]()
$232
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/16:20 am -
1 stop3h 20m
Sat 12/56:00 am -
2 stops9h 10m
Deal found 9/15![Southwest logo]()
$246
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1710:27 am -
2 stops7h 40m
Sat 10/2410:46 am -
1 stop4h 30m
Deal found 9/15![United Airlines logo]()
$261
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1011:31 am -
1 stop4h 37m
Mon 10/125:50 pm -
1 stop7h 29m
Deal found 9/15![American Airlines logo]()
$271
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/107:22 am -
1 stop6h 05m
Mon 10/125:50 pm -
1 stop7h 38m
Deal found 9/14![American Airlines logo]()
$272
This Southwest deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/235:00 am -
1 stop7h 45m
Mon 10/264:30 pm -
1 stop7h 45m
Deal found 9/17![Southwest logo]()
$291
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/510:28 am -
1 stop6h 08m
Wed 10/146:15 am -
1 stop4h 32m
Deal found 9/17![Delta logo]()
$291
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/244:00 pm -
1 stop6h 59m
Wed 10/285:20 pm -
1 stop5h 59m
Deal found 9/15![Delta logo]()
$291
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/243:05 pm -
1 stop4h 44m
Wed 10/286:00 am -
2 stops9h 33m
Deal found 9/15![United Airlines logo]()
$296
This Southwest deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/157:55 pm -
1 stop13h 05m
Mon 10/197:20 pm -
1 stop6h 15m
Deal found 9/14![Southwest logo]()
$299
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/235:31 pm -
1 stop5h 28m
Mon 10/266:55 pm -
1 stop6h 01m
Deal found 9/15![Delta logo]()
$306
Best flights from Missouri to BuffaloDiscover carefully curated flight deals from Missouri to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 18, 2026.
Discover carefully curated flight deals from Missouri to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 18, 2026.
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/16:20 am -
1 stop3h 20m
Sat 12/56:00 am -
2 stops9h 10m
Deal found 9/15![Southwest logo]()
$246
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/243:05 pm -
1 stop4h 44m
Wed 10/281:53 pm -
1 stop5h 12m
Deal found 9/15![United Airlines logo]()
$291
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:00 am -
2 stops8h 11m
Wed 10/2812:21 pm -
1 stop5h 26m
Deal found 9/15![Delta logo]()
$296
This Southwest deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/235:00 am -
1 stop7h 45m
Mon 10/264:30 pm -
1 stop7h 45m
Deal found 9/17![Southwest logo]()
$291
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/61:05 pm -
1 stop6h 47m
Sat 1/95:45 pm -
1 stop5h 00m
Deal found 9/16![United Airlines logo]()
$335
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/253:55 pm -
1 stop5h 40m
Fri 11/278:05 am -
2 stops12h 05m
Deal found 9/16![Southwest logo]()
$337
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/205:46 pm -
1 stop5h 04m
Thu 10/227:00 am -
1 stop4h 26m
Deal found 9/16![United Airlines logo]()
$352
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/2411:45 am -
1 stop5h 55m
Fri 11/276:35 am -
1 stop4h 14m
Deal found 9/13![Delta logo]()
$404
This Southwest deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/161:00 pm -
1 stop4h 40m
Sun 10/185:50 am -
1 stop4h 30m
Deal found 9/17![Southwest logo]()
$341
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/36:34 am -
1 stop4h 01m
Sun 11/86:56 pm -
1 stop6h 00m
Deal found 9/13![Delta logo]()
$404
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/191:29 pm -
1 stop6h 18m
Thu 10/227:00 am -
1 stop6h 13m
Deal found 9/16![United Airlines logo]()
$377
This Southwest deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/85:45 am -
1 stop3h 40m
Mon 11/165:00 pm -
1 stop6h 00m
Deal found 9/14![Southwest logo]()
$345
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/255:55 pm -
1 stop3h 47m
Sat 11/286:10 am -
1 stop4h 39m
Deal found 9/14![Delta logo]()
$411
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2411:19 am -
1 stop4h 24m
Wed 10/285:58 pm -
1 stop6h 00m
Deal found 9/13![United Airlines logo]()
$408
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/207:25 am -
2 stops6h 10m
Thu 10/226:00 am -
2 stops8h 15m
Deal found 9/16![Southwest logo]()
$386
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/241:09 pm -
1 stop6h 27m
Tue 12/88:17 am -
1 stop8h 57m
Deal found 9/17![United Airlines logo]()
$413
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/66:25 am -
1 stop4h 40m
Sun 10/117:55 pm -
1 stop5h 25m
Deal found 9/15![Southwest logo]()
$386
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/76:29 am -
1 stop7h 41m
Tue 10/133:05 pm -
2 stops9h 39m
Deal found 9/15![United Airlines logo]()
$431
Last-minute flights from Missouri to BuffaloDiscover last-minute flight deals from Missouri to Buffalo. Data last updated September 18, 2026 and is based on user searches.
Discover last-minute flight deals from Missouri to Buffalo. Data last updated September 18, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/510:28 am -
1 stop6h 08m
Wed 10/146:15 am -
1 stop4h 32m
Deal found 9/17![Delta logo]()
$291
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1011:31 am -
1 stop4h 37m
Mon 10/125:50 pm -
1 stop7h 29m
Deal found 9/15![American Airlines logo]()
$271
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/107:22 am -
1 stop6h 05m
Mon 10/125:50 pm -
1 stop7h 38m
Deal found 9/14![American Airlines logo]()
$272
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:00 am -
1 stop5h 46m
Wed 10/218:00 am -
1 stop5h 35m
Deal found 9/16![American Airlines logo]()
$227
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/142:20 pm -
2 stops7h 05m
Wed 10/218:00 am -
1 stop4h 35m
Deal found 9/16![Southwest logo]()
$232
This Southwest deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/157:55 pm -
1 stop13h 05m
Mon 10/197:20 pm -
1 stop6h 15m
Deal found 9/14![Southwest logo]()
$299
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1710:27 am -
2 stops7h 40m
Sat 10/2410:46 am -
1 stop4h 30m
Deal found 9/15![United Airlines logo]()
$261
This Southwest deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/205:50 am -
1 stop3h 35m
Sun 10/258:00 am -
1 stop6h 00m
Deal found 9/17![Southwest logo]()
$312
This Southwest deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/235:00 am -
1 stop7h 45m
Mon 10/264:30 pm -
1 stop7h 45m
Deal found 9/17![Southwest logo]()
$291
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/235:31 pm -
1 stop5h 28m
Mon 10/266:55 pm -
1 stop6h 01m
Deal found 9/15![Delta logo]()
$306
This Southwest deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/235:50 pm -
1 stop4h 55m
Mon 10/265:45 pm -
1 stop7h 45m
Deal found 9/14![Southwest logo]()
$325
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/243:05 pm -
1 stop4h 44m
Wed 10/281:53 pm -
1 stop5h 12m
Deal found 9/15![United Airlines logo]()
$291
One-way flights from Missouri to BuffaloSearch for one-way flight options from Missouri to Buffalo. Find affordable one-way fares based on user searches. Data last updated September 18, 2026.
Search for one-way flight options from Missouri to Buffalo. Find affordable one-way fares based on user searches. Data last updated September 18, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:35 pm -
1 stop17h 24m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![Frontier logo]()
$77
This Southwest deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/143:20 pm -
1 stop6h 05m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![Southwest logo]()
$114
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/105:46 pm -
1 stop5h 04m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![United Airlines logo]()
$128
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/131:29 pm -
1 stop6h 18m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![United Airlines logo]()
$146
This Southwest deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/234:30 pm -
2 stops6h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![Southwest logo]()
$148
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/72:10 pm -
2 stops7h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![Southwest logo]()
$167
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/115:27 pm -
1 stop5h 32m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![American Airlines logo]()
$209
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/116:10 am -
1 stop8h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![United Airlines logo]()
$219
This deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/75:46 pm -
1 stop5h 04m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![United Airlines logo]()
$229
This Southwest deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/138:30 am -
2 stops5h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![Southwest logo]()
$231
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/116:00 am -
2 stops7h 23m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![United Airlines logo]()
$244
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/299:30 am -
1 stop4h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![United Airlines logo]()
$249
Find flight deals from Missouri to Buffalo
Keep the following information in mind while searching for Missouri to Buffalo flight deals. Data was last updated September 18, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $227 (American Airlines) |
One-way from | $77 (Kiwi.com) |
Popular in | April |
Cheapest in | February |
Average price | $354 |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 18, 2026.
Use the filters below to find and compare flights from Missouri to Buffalo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisBuffalo
STL Lambert-St Louis - BUF Buffalo
STLBUF
Lambert-St Louis
Fri 10/23
6:35 pm-12:59 pm
1 stop17h 24m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$77
St. LouisBuffalo
STL Lambert-St Louis - BUF Buffalo
STLBUF
Lambert-St Louis
Wed 10/14
3:20 pm-10:25 pm
1 stop6h 05m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$114
Kansas CityBuffalo
MCI Kansas City - BUF Buffalo
MCIBUF
Kansas City
Sat 10/10
5:46 pm-11:50 pm
1 stop5h 04m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$128
Kansas CityBuffalo
MCI Kansas City - BUF Buffalo
MCIBUF
Kansas City
Wed 10/7
4:23 pm-11:59 pm
1 stop6h 36m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$128
St. LouisBuffalo
STL Lambert-St Louis - BUF Buffalo
STLBUF
Lambert-St Louis
Tue 10/13
1:29 pm-8:47 pm
1 stop6h 18m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$146
St. LouisBuffalo
STL Lambert-St Louis - BUF Buffalo
STLBUF
Lambert-St Louis
Fri 10/23
4:30 pm-11:45 pm
2 stops6h 15m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$148
Kansas CityBuffalo
MCI Kansas City - BUF Buffalo
MCIBUF
Kansas City
Wed 10/7
2:10 pm-10:25 pm
2 stops7h 15m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$167
Kansas CityBuffalo
MCI Kansas City - BUF Buffalo
MCIBUF
Kansas City
Sun 10/11
6:10 am-3:10 pm
1 stop8h 00m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$219
Kansas CityBuffalo
MCI Kansas City - BUF Buffalo
MCIBUF
Kansas City
Wed 10/7
5:46 pm-11:50 pm
1 stop5h 04m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$229
St. LouisBuffalo
STL Lambert-St Louis - BUF Buffalo
STLBUF
Lambert-St Louis
Tue 10/13
8:30 am-3:20 pm
2 stops5h 50m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$231
Showing 1-10 of 34 resultsSorted by cheapest first
Best time to book a flight from Missouri to Buffalo
Have a flexible travel schedule? Discover the best time to fly to Buffalo from Missouri with our price prediction graph.
STL-BUF
MCI-BUF
SGF-BUF
COU-BUF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to Buffalo
USMO-BUF
STL-BUF
MCI-BUF
SGF-BUF
COU-BUF
What is the cheapest month to book a flight from Missouri to Buffalo?
Currently, February is the cheapest month in which you can book a flight from Missouri to Buffalo (average of $337). Flying from Missouri to Buffalo in December is currently the most expensive (average of $483). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Missouri to Buffalo?
Airfare is below average for this route at the moment.
Missouri to Buffalo flights typically cost between $284 and $479 in October.The cheapest round-trip price found within the last 5 days was $227 on American Airlines (Oct 14-Oct 21).
Related info for your journey
Find useful and relevant information for your journey from Missouri to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Buffalo?
Book flights to Buffalo if you plan to visit one of these locationsCheektowaga
Lockport
Amherst
Williamsville
Orchard Park
Eden
Bowmansville
Browse thousands of different options on Cheapflights for your next trip
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Alternative routes for Missouri to Buffalo
See prices for flight routes from nearby airports that may be better suited for you.
Other flights to Buffalo
Explore flights to Buffalo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 18, 2026.
Complete your trip
Complete your trip to Buffalo by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Missouri to Buffalo by cabin class
Find flights from Missouri to Buffalo, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Missouri and Buffalo flights
Browse other Missouri and Buffalo flight options. Last updated on September 18, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Missouri to Buffalo flights
Consider these flights traveling from Missouri to Buffalo.
Top 5 airlines flying from Missouri to Buffalo
Discover the top 5 airlines that operate flights from Missouri to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 18, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$115 | Average$126 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$145 | Average$432 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$233 | Average$408 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$248 | Average$472 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$298 | Average$416 | FlexibilityNo cancel fee | On-time63% |