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$159+ Cheap flights from Iowa to Buffalo (BUF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/20. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — BUF
Jul 10 — Jul 171
Fri 7/10
Fri 7/17
1 adult, Economy
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Cheap flight deals from Iowa to Buffalo

Cheapest flights from Iowa to Buffalo
Explore the most affordable flight options available from Iowa to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 10, 2026.

This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/265:55 pm
OMA
-
BUF
1 stop5h 03m
Delta
Mon 8/317:52 pm
BUF
-
OMA
1 stop4h 06m
Delta
Deal found 6/8$290
This Southwest deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/265:50 am
OMA
-
BUF
1 stop4h 30m
Southwest
Mon 8/317:10 pm
BUF
-
OMA
1 stop3h 55m
Southwest
Deal found 6/7$291
This Southwest deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/92:40 pm
DSM
-
BUF
1 stop4h 55m
Southwest
Sat 9/126:45 am
BUF
-
DSM
1 stop8h 25m
Southwest
Deal found 6/7$291
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/16:52 pm
MLI
-
BUF
1 stop4h 46m
American Airlines
Sat 7/46:00 am
BUF
-
MLI
1 stop5h 58m
American Airlines
Deal found 6/10$309
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/275:55 pm
OMA
-
BUF
1 stop5h 03m
Delta
Mon 8/316:40 am
BUF
-
OMA
1 stop4h 06m
Delta
Deal found 6/8$317
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/2111:25 am
CID
-
BUF
1 stop4h 31m
United Airlines
Sun 8/235:58 pm
BUF
-
CID
1 stop4h 21m
United Airlines
Deal found 6/8$319
This American Airlines deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/36:50 pm
MLI
-
BUF
1 stop4h 12m
American Airlines
Sun 7/56:32 am
BUF
-
MLI
1 stop5h 41m
American Airlines
Deal found 6/7$319
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/246:52 pm
MLI
-
BUF
1 stop4h 46m
American Airlines
Sat 6/276:00 am
BUF
-
MLI
1 stop5h 41m
American Airlines
Deal found 6/10$339
This American Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/216:24 am
OMA
-
BUF
1 stop7h 02m
American Airlines
Fri 9/257:59 am
BUF
-
OMA
1 stop4h 49m
American Airlines
Deal found 6/8$344
This American Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/166:00 am
DSM
-
BUF
1 stop5h 42m
American Airlines
Sun 9/205:44 pm
BUF
-
DSM
1 stop6h 57m
American Airlines
Deal found 6/9$345
This American Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/301:50 pm
OMA
-
BUF
1 stop8h 00m
American Airlines
Fri 7/36:27 am
BUF
-
OMA
1 stop5h 51m
American Airlines
Deal found 6/9$355
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/86:00 am
DSM
-
BUF
1 stop4h 22m
Delta
Wed 7/156:29 am
BUF
-
DSM
1 stop4h 16m
Delta
Deal found 6/10$355

Find flight deals from Iowa to Buffalo

Keep the following information in mind while searching for Iowa to Buffalo flight deals. Data was last updated June 10, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$290
(Delta)

One-way from

$159
(United Airlines)

Popular in

March

Cheapest in

October

Average price

$406
Provider with most accurate pricing for Des Moines-Buffalo flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Buffalo flights.
Search Deals
From Iowa to Buffalo
Search Deals
One-way flight from Iowa to Buffalo
Search Deals
Highest demand for flights based on searches. 14% potential increase in price ($69 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 8% potential price decrease ($33 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in June 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 10, 2026.
Use the filters below to find and compare flights from Iowa to Buffalo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

OmahaBuffalo

OMA - BUF

OMABUF

Omaha Eppley Airfield

Wed 8/26

5:50 am-2:20 pm

2 stops7h 30m

Buffalo

Mon 8/31

7:10 pm-10:05 pm

1 stop3h 55m

$296
Quickest round-trip

OmahaBuffalo

OMA - BUF

OMABUF

Omaha Eppley Airfield

Thu 8/27

6:25 am-11:22 am

1 stop3h 57m

Buffalo

Mon 8/31

7:52 pm-10:58 pm

1 stop4h 06m

$317

MolineBuffalo

MLI - BUF

MLIBUF

Moline Quad-City

Fri 7/3

6:50 pm-12:02 am

1 stop4h 12m

Buffalo

Sun 7/5

6:32 am-11:13 am

1 stop5h 41m

$319

MolineBuffalo

MLI - BUF

MLIBUF

Moline Quad-City

Thu 9/17

5:10 pm-11:54 pm

1 stop5h 44m

Buffalo

Mon 9/21

6:05 am-10:23 am

1 stop5h 18m

$319

MolineBuffalo

MLI - BUF

MLIBUF

Moline Quad-City

Fri 7/17

6:50 pm-11:59 pm

1 stop4h 09m

Buffalo

Sun 7/19

6:32 am-11:23 am

1 stop5h 51m

$319

MolineBuffalo

MLI - BUF

MLIBUF

Moline Quad-City

Tue 6/23

1:15 pm-9:03 pm

1 stop6h 48m

Buffalo

Sat 6/27

10:57 am-3:05 pm

1 stop5h 08m

$369

Cedar RapidsBuffalo

CID - BUF

CIDBUF

Cedar Rapids

Fri 8/21

11:51 am-9:48 pm

2 stops8h 57m

Buffalo

Sun 8/23

6:09 pm-12:18 am

1 stop7h 09m

$369

OmahaBuffalo

OMA - BUF

OMABUF

Omaha Eppley Airfield

Thu 8/6

6:48 am-5:08 pm

2 stops9h 20m

Buffalo

Mon 8/10

4:49 pm-11:38 pm

1 stop7h 49m

$369

OmahaBuffalo

OMA - BUF

OMABUF

Omaha Eppley Airfield

Tue 10/6

1:55 pm-10:46 pm

1 stop7h 51m

Buffalo

Wed 10/7

7:00 am-12:14 pm

1 stop6h 14m

$370

OmahaBuffalo

OMA - BUF

OMABUF

Omaha Eppley Airfield

Tue 6/30

12:50 pm-11:54 pm

2 stops10h 04m

Buffalo

Fri 7/3

4:13 pm-12:19 am

2 stops9h 06m

$383

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/9

Showing 1-10 of 48 resultsSorted by cheapest first
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Best time to book a flight from Iowa to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Buffalo

What is the cheapest month to book a flight from Iowa to Buffalo?

Currently, September is the cheapest month in which you can book a flight from Iowa to Buffalo (average of $208). Flying from Iowa to Buffalo in May is currently the most expensive (average of $422). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Iowa to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Buffalo from Iowa?

    Most people fly into Buffalo (BUF) if they book a flight to Buffalo from Iowa. Buffalo is conveniently located just 8.3 mi from Buffalo’s city center.

  • How long is the flight from Iowa to Buffalo?

    Airlines like Southwest, Delta, and American Airlines fly from Iowa to Buffalo in about 3h 57m. The time it takes to get you to your destination can typically vary by up to 58m. There are 885 mi between Iowa and Buffalo. This flight may include one or multiple stops.

  • What are the most popular routes from Iowa to Buffalo?

    While some choose either Des Moines - Buffalo or Cedar Rapids - Buffalo, Omaha Eppley Airfield - Buffalo is the most popular route from Iowa to Buffalo.

  • Can I find deals for flights from Iowa to Buffalo that include hotel bookings?

    Yes. In addition to deals on Iowa to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Buffalo.

  • Can I find deals for business class flights from Iowa to Buffalo?

    Yes. Cheapflights offers flight deals from Iowa to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to Buffalo?

    Currently, September is the cheapest month in which you can book a flight from Iowa to Buffalo (average of $208). Flying from Iowa to Buffalo in May is currently the most expensive (average of $422). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Lockport
Cheektowaga
Amherst
Batavia
Williamsville
Orchard Park
Eden

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Alternative routes for Iowa to Buffalo

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Iowa to Buffalo

Discover the top 3 airlines that operate flights from Iowa to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 10, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$216Average$332FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$225Average$393FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$238Average$340FlexibilityNo cancel feeOn-time71%

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