HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Buffalo

$140+ Cheap flights from Iowa to Buffalo (BUF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/23. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — BUF
Aug 28 — Sep 41
Fri 8/28
Fri 9/4
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Iowa to Buffalo with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Iowa to Buffalo

Cheapest flights from Iowa to Buffalo
Explore the most affordable flight options available from Iowa to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2026.

This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/2210:26 am
OMA
-
BUF
1 stop3h 48m
Delta
Wed 8/263:54 pm
BUF
-
OMA
1 stop6h 00m
Delta
Deal found 7/27$279
This United Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/2211:19 am
OMA
-
BUF
1 stop4h 33m
United Airlines
Tue 8/256:00 am
BUF
-
OMA
2 stops9h 04m
United Airlines
Deal found 7/26$284
This Delta deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/245:55 pm
OMA
-
BUF
1 stop5h 03m
Delta
Tue 9/13:54 pm
BUF
-
OMA
1 stop6h 00m
Delta
Deal found 7/25$289
This American Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/246:55 am
OMA
-
BUF
2 stops9h 13m
American Airlines
Tue 9/110:43 am
BUF
-
OMA
2 stops9h 24m
American Airlines
Deal found 7/25$290
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/112:22 pm
OMA
-
BUF
1 stop4h 42m
American Airlines
Sat 12/512:43 pm
BUF
-
OMA
2 stops7h 37m
American Airlines
Deal found 7/26$294
This American Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1012:23 pm
OMA
-
BUF
2 stops9h 05m
American Airlines
Tue 10/135:51 pm
BUF
-
OMA
2 stops7h 34m
American Airlines
Deal found 7/28$295
This Southwest deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/15:05 am
OMA
-
BUF
1 stop4h 20m
Southwest
Tue 10/67:00 pm
BUF
-
OMA
1 stop4h 20m
Southwest
Deal found 7/24$302
This American Airlines deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/86:55 am
OMA
-
BUF
2 stops9h 13m
American Airlines
Sat 9/127:15 am
BUF
-
OMA
1 stop7h 21m
American Airlines
Deal found 7/24$306
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/146:00 pm
OMA
-
BUF
1 stop4h 53m
Delta
Thu 9/176:20 am
BUF
-
OMA
1 stop4h 24m
Delta
Deal found 7/28$309
This American Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/23:57 pm
CID
-
BUF
1 stop5h 13m
American Airlines
Tue 10/68:00 am
BUF
-
CID
1 stop6h 22m
American Airlines
Deal found 7/28$319
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/295:09 pm
MLI
-
BUF
1 stop5h 50m
Delta
Sat 9/55:13 pm
BUF
-
MLI
1 stop6h 06m
Delta
Deal found 7/27$319
This American Airlines deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/95:00 am
CID
-
BUF
1 stop5h 48m
American Airlines
Wed 9/164:55 pm
BUF
-
CID
2 stops8h 22m
American Airlines
Deal found 7/24$324

Find flight deals from Iowa to Buffalo

Keep the following information in mind while searching for Iowa to Buffalo flight deals. Data was last updated July 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$279
(Delta)

One-way from

$140
(United Airlines)

Popular in

March

Cheapest in

October

Average price

$452
Provider with most accurate pricing for Des Moines-Buffalo flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Buffalo flights.
Search Deals
From Iowa to Buffalo
Search Deals
One-way flight from Iowa to Buffalo
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($43 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 7% potential price decrease ($30 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2026.
Use the filters below to find and compare flights from Iowa to Buffalo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

OmahaBuffalo

OMA - BUF

OMABUF

Omaha Eppley Airfield

Mon 8/31

5:35 am-10:45 am

1 stop4h 10m

Buffalo

Wed 9/2

6:25 pm-9:45 pm

1 stop4h 20m

$279

OmahaBuffalo

OMA - BUF

OMABUF

Omaha Eppley Airfield

Sat 10/10

5:58 pm-10:38 pm

1 stop3h 40m

Buffalo

Tue 10/13

6:10 am-9:50 am

1 stop4h 40m

$279

OmahaBuffalo

OMA - BUF

OMABUF

Omaha Eppley Airfield

Sat 8/22

11:19 am-4:52 pm

1 stop4h 33m

Buffalo

Tue 8/25

8:55 am-4:28 pm

1 stop8h 33m

$279

OmahaBuffalo

OMA - BUF

OMABUF

Omaha Eppley Airfield

Tue 9/8

3:05 pm-8:40 pm

1 stop4h 35m

Buffalo

Sat 9/12

7:50 am-11:45 am

1 stop4h 55m

$279

OmahaBuffalo

OMA - BUF

OMABUF

Omaha Eppley Airfield

Tue 9/8

6:00 pm-10:35 pm

1 stop3h 35m

Buffalo

Sat 9/12

4:59 pm-10:52 pm

1 stop6h 53m

$279
Quickest round-trip

OmahaBuffalo

OMA - BUF

OMABUF

Omaha Eppley Airfield

Sat 8/22

10:26 am-3:14 pm

1 stop3h 48m

Buffalo

Wed 8/26

7:52 pm-10:58 pm

1 stop4h 06m

$279

OmahaBuffalo

OMA - BUF

OMABUF

Omaha Eppley Airfield

Sat 8/22

6:00 am-4:52 pm

2 stops9h 52m

Buffalo

Wed 8/26

10:30 am-2:04 pm

1 stop4h 34m

$284

OmahaBuffalo

OMA - BUF

OMABUF

Omaha Eppley Airfield

Thu 10/1

4:00 pm-11:40 pm

2 stops6h 40m

Buffalo

Tue 10/6

4:25 pm-10:20 pm

2 stops6h 55m

$289

MolineBuffalo

MLI - BUF

MLIBUF

Moline Quad-City

Wed 11/11

5:13 pm-11:59 pm

1 stop5h 46m

Buffalo

Sun 11/15

6:00 am-10:20 am

1 stop5h 20m

$319

MolineBuffalo

MLI - BUF

MLIBUF

Moline Quad-City

Sat 8/29

5:09 pm-11:59 pm

1 stop5h 50m

Buffalo

Sat 9/5

5:13 pm-10:19 pm

1 stop6h 06m

$319

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/26

Showing 1-10 of 56 resultsSorted by cheapest first
1
2
3
...
6

Best time to book a flight from Iowa to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Buffalo

What is the cheapest month to book a flight from Iowa to Buffalo?

Currently, October is the cheapest month in which you can book a flight from Iowa to Buffalo (average of $269). Flying from Iowa to Buffalo in March is currently the most expensive (average of $772). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Iowa to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Buffalo from Iowa?

    Most people fly into Buffalo (BUF) if they book a flight to Buffalo from Iowa. Buffalo is conveniently located just 8.3 mi from Buffalo’s city center.

  • How long is the flight from Iowa to Buffalo?

    Airlines like Southwest, Delta, and American Airlines fly from Iowa to Buffalo in about 3h 40m. The time it takes to get you to your destination can typically vary by up to 46m. There are 885 mi between Iowa and Buffalo. This flight may include one or multiple stops.

  • What are the most popular routes from Iowa to Buffalo?

    While some choose either Des Moines - Buffalo or Moline Quad-City - Buffalo, Omaha Eppley Airfield - Buffalo is the most popular route from Iowa to Buffalo.

  • Can I find deals for flights from Iowa to Buffalo that include hotel bookings?

    Yes. In addition to deals on Iowa to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Buffalo.

  • Can I find deals for business class flights from Iowa to Buffalo?

    Yes. Cheapflights offers flight deals from Iowa to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to Buffalo?

    Currently, October is the cheapest month in which you can book a flight from Iowa to Buffalo (average of $269). Flying from Iowa to Buffalo in March is currently the most expensive (average of $772). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Lockport
Cheektowaga
Amherst
Williamsville
Orchard Park
Eden
Bowmansville

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Iowa to Buffalo

See prices for flight routes from nearby airports that may be better suited for you.
San Francisco to Newark flights
San Francisco to John F Kennedy Intl flights
San Francisco to LaGuardia flights
Los Angeles to John F Kennedy Intl flights
Los Angeles to Newark flights
Dallas/Fort Worth to LaGuardia flights
Dallas/Fort Worth to John F Kennedy Intl flights
Dallas/Fort Worth to Newark flights
O'Hare Intl to John F Kennedy Intl flights
Los Angeles to LaGuardia flights
Miami to Newark flights
Hobby to LaGuardia flights
Atlanta to John F Kennedy Intl flights
Hobby to Newark flights
Orlando to LaGuardia flights
O'Hare Intl to Newark flights
Seattle to John F Kennedy Intl flights
Raleigh to John F Kennedy Intl flights
Ontario to John F Kennedy Intl flights
Orlando to Newark flights
Miami to LaGuardia flights
Seattle to Newark flights
Atlanta to Newark flights
Fort Lauderdale to Newark flights
Atlanta to LaGuardia flights
Raleigh to LaGuardia flights
Miami to John F Kennedy Intl flights
Fort Lauderdale to John F Kennedy Intl flights
O'Hare Intl to LaGuardia flights
Austin to John F Kennedy Intl flights
Orlando to John F Kennedy Intl flights
Austin to Newark flights
George Bush Intcntl to LaGuardia flights
Fort Lauderdale to LaGuardia flights
George Bush Intcntl to Newark flights
Sky Harbor Intl to John F Kennedy Intl flights
Detroit to LaGuardia flights
Raleigh to Newark flights
Charlotte to LaGuardia flights
Tampa to Newark flights
Detroit to Newark flights
Charlotte to Newark flights
Denver to LaGuardia flights
Hobby to John F Kennedy Intl flights
Tampa to John F Kennedy Intl flights
George Bush Intcntl to John F Kennedy Intl flights
Denver to Newark flights
Tampa to LaGuardia flights
Minneapolis to Newark flights

Top 3 airlines flying from Iowa to Buffalo

Discover the top 3 airlines that operate flights from Iowa to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$216Average$332FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$238Average$318FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$278Average$377FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.