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$128+ Cheap flights from Iowa to Buffalo (BUF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/12. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — BUF
Dec 4 — Dec 111
Thu 12/4
Thu 12/11
1 adult, Economy
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Find flight deals from Iowa to Buffalo

Cheapest flights from Iowa to Buffalo
Explore the most affordable flight options available from Iowa to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 4, 2025.

This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/135:43 pmMLI - BUF
1 stop5h 24mAmerican Airlines
Sat 1/106:00 amBUF - MLI
1 stop5h 58mAmerican Airlines
Deal found 11/3$249
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/135:08 pmMLI - BUF
1 stop5h 51mDelta
Sat 1/106:03 amBUF - MLI
2 stops11h 23mDelta
Deal found 11/3$254
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/25:29 pmOMA - BUF
1 stop4h 29mDelta
Sat 12/66:12 amBUF - OMA
1 stop4h 31mDelta
Deal found 11/3$317
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/25:29 pmOMA - BUF
1 stop4h 29mDelta
Thu 12/45:50 pmBUF - OMA
1 stop4h 09mDelta
Deal found 11/3$331
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/35:29 pmOMA - BUF
1 stop4h 29mDelta
Sun 12/76:12 amBUF - OMA
1 stop4h 26mDelta
Deal found 11/3$352
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/106:17 amDSM - BUF
1 stop5h 17mDelta
Fri 12/191:16 pmBUF - DSM
1 stop4h 00mDelta
Deal found 11/3$352
This United Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/103:25 pmOMA - BUF
1 stop4h 50mUnited Airlines
Fri 12/127:00 amBUF - OMA
2 stops10h 22mUnited Airlines
Deal found 11/4$357
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/135:45 amDSM - BUF
2 stops10h 08mUnited Airlines
Sat 12/205:35 pmBUF - DSM
1 stop5h 05mUnited Airlines
Deal found 11/3$357
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/245:29 pmOMA - BUF
1 stop4h 28mDelta
Wed 11/266:12 amBUF - OMA
1 stop4h 38mDelta
Deal found 11/3$360
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/248:02 amDSM - BUF
1 stop4h 15mUnited Airlines
Fri 11/287:00 amBUF - DSM
1 stop6h 14mUnited Airlines
Deal found 11/3$360
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/75:29 pmOMA - BUF
1 stop4h 29mDelta
Thu 12/116:12 amBUF - OMA
1 stop4h 26mDelta
Deal found 11/3$366
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/171:17 pmDSM - BUF
2 stops8h 40mAmerican Airlines
Mon 12/226:00 amBUF - DSM
1 stop8h 21mAmerican Airlines
Deal found 11/3$367

Cheap flight deals from Iowa to Buffalo

Keep the following information in mind while searching for Iowa to Buffalo flight deals. Data was last updated November 4, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$249
(American Airlines)

One-way from

$128
(Kiwi.com)

Popular in

February

Cheapest in

October

Average price

$311
Provider with most accurate pricing for Des Moines-Buffalo flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Buffalo flights.
Search Deals
From Iowa to Buffalo
Search Deals
One-way flight from Iowa to Buffalo
Search Deals
Highest demand for flights based on searches. 22% potential increase in price ($122 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($24 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 4, 2025.
Use the filters below to find and compare flights from Iowa to Buffalo that are best for you.

Fly from

Iowa

Fly to

Buffalo

Route

Depart

Return

Price

MolineBuffalo

MLI - BUF

MLIBUF

Moline Quad-City

Sat 12/13

5:08 pm-11:59 pm

1 stop5h 51m

Buffalo

Sat 1/10

6:03 am-4:26 pm

2 stops11h 23m

$254

MolineBuffalo

MLI - BUF

MLIBUF

Moline Quad-City

Sat 12/13

10:52 am-10:54 pm

2 stops11h 02m

Buffalo

Sat 1/10

5:16 am-3:27 pm

2 stops11h 11m

$303

OmahaBuffalo

OMA - BUF

OMABUF

Omaha Eppley Airfield

Tue 12/2

5:29 pm-10:58 pm

1 stop4h 29m

Buffalo

Sat 12/6

6:12 am-9:43 am

1 stop4h 31m

$317

OmahaBuffalo

OMA - BUF

OMABUF

Omaha Eppley Airfield

Sat 12/6

3:08 pm-11:59 pm

1 stop7h 51m

Buffalo

Wed 12/10

5:50 pm-8:59 pm

1 stop4h 09m

$317

Cedar RapidsBuffalo

CID - BUF

CIDBUF

Cedar Rapids

Wed 3/25

1:10 pm-8:28 pm

1 stop6h 18m

Buffalo

Sat 3/28

7:00 am-11:49 am

1 stop5h 49m

$319

MolineBuffalo

MLI - BUF

MLIBUF

Moline Quad-City

Wed 2/18

6:00 am-11:46 am

1 stop4h 46m

Buffalo

Sat 2/21

6:00 am-3:04 pm

1 stop10h 04m

$319

OmahaBuffalo

OMA - BUF

OMABUF

Omaha Eppley Airfield

Mon 12/8

5:29 pm-10:58 pm

1 stop4h 29m

Buffalo

Wed 12/10

5:50 pm-8:59 pm

1 stop4h 09m

$331

OmahaBuffalo

OMA - BUF

OMABUF

Omaha Eppley Airfield

Thu 12/11

6:19 am-12:34 pm

1 stop5h 15m

Buffalo

Sat 12/13

5:50 pm-8:59 pm

1 stop4h 09m

$331

OmahaBuffalo

OMA - BUF

OMABUF

Omaha Eppley Airfield

Thu 12/4

10:18 am-5:10 pm

1 stop5h 52m

Buffalo

Sat 12/6

6:12 am-9:43 am

1 stop4h 31m

$331

OmahaBuffalo

OMA - BUF

OMABUF

Omaha Eppley Airfield

Tue 12/2

5:29 pm-10:58 pm

1 stop4h 29m

Buffalo

Thu 12/4

5:50 pm-8:59 pm

1 stop4h 09m

$331

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/4

Showing 1-10 of 47 results
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Best time to book a flight from Iowa to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Buffalo

What is the cheapest month to book a flight from Iowa to Buffalo?

Currently, June is the cheapest month in which you can book a flight from Iowa to Buffalo (average of $100). Flying from Iowa to Buffalo in December is currently the most expensive (average of $295). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Iowa to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Buffalo from Iowa?

    Most people fly into Buffalo (BUF) if they book a flight to Buffalo from Iowa. Buffalo is conveniently located just 8.3 mi from Buffalo’s city center.

  • How long is the flight from Iowa to Buffalo?

    Airlines like Delta, American Airlines, and United Airlines fly from Iowa to Buffalo in about 5h 51m. The time it takes to get you to your destination can typically vary by up to 5h 11m. There are 611 mi between Iowa and Buffalo. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Iowa to Buffalo one-way?

    For one-way options, check prices for Frontier. According to our data, you can fly for as low as $129. Users have also found prices from $157 and $159 on Delta and United Airlines, respectively.

  • What are the most popular routes from Iowa to Buffalo?

    While some choose either Omaha Eppley Airfield - Buffalo or Cedar Rapids - Buffalo, Des Moines - Buffalo is the most popular route from Iowa to Buffalo.

  • Can I find deals for flights from Iowa to Buffalo that include hotel bookings?

    Yes. In addition to deals on Iowa to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Buffalo.

  • Can I find deals for business class flights from Iowa to Buffalo?

    Yes. Cheapflights offers flight deals from Iowa to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to Buffalo?

    Currently, June is the cheapest month in which you can book a flight from Iowa to Buffalo (average of $100). Flying from Iowa to Buffalo in December is currently the most expensive (average of $295). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Lockport
Cheektowaga
Orchard Park
Batavia
Williamsville
Eden
Amherst
West Seneca

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See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Iowa to Buffalo

Discover the top 3 airlines that operate flights from Iowa to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 4, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$148Average$332FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$238Average$328FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$278Average$444FlexibilityNo cancel feeOn-time69%

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