HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Buffalo

$143+ Cheap flights from Iowa to Buffalo (BUF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/8. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — BUF
Mar 28 — Apr 41
Sat 3/28
Sat 4/4
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Iowa to Buffalo with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Iowa to Buffalo

Cheapest flights from Iowa to Buffalo
Explore the most affordable flight options available from Iowa to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 26, 2026.

This American Airlines deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/106:28 pm
CID
-
BUF
1 stop4h 12m
American Airlines
Sat 3/146:00 am
BUF
-
CID
1 stop4h 13m
American Airlines
Deal found 2/23$279
This United Airlines deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/2110:00 am
CID
-
BUF
1 stop5h 46m
United Airlines
Sun 5/247:00 am
BUF
-
CID
1 stop4h 33m
United Airlines
Deal found 2/25$285
This Delta deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/135:12 pm
OMA
-
BUF
1 stop5h 20m
Delta
Tue 5/195:41 pm
BUF
-
OMA
1 stop6h 34m
Delta
Deal found 2/25$285
This American Airlines deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/134:02 pm
OMA
-
BUF
1 stop4h 34m
American Airlines
Tue 5/197:00 am
BUF
-
OMA
2 stops9h 33m
American Airlines
Deal found 2/25$299
This American Airlines deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/203:31 pm
MLI
-
BUF
1 stop6h 10m
American Airlines
Mon 3/305:59 pm
BUF
-
MLI
1 stop6h 38m
American Airlines
Deal found 2/25$299
This American Airlines deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2212:00 pm
DSM
-
BUF
1 stop4h 30m
American Airlines
Mon 4/276:00 am
BUF
-
DSM
1 stop5h 26m
American Airlines
Deal found 2/25$300
This American Airlines deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/113:31 pm
MLI
-
BUF
1 stop6h 10m
American Airlines
Sun 3/155:59 pm
BUF
-
MLI
1 stop6h 38m
American Airlines
Deal found 2/24$304
This Delta deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/105:15 pm
MLI
-
BUF
1 stop5h 31m
Delta
Mon 3/164:47 pm
BUF
-
MLI
1 stop6h 43m
Delta
Deal found 2/25$309
This American Airlines deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/302:23 pm
ALO
-
BUF
1 stop6h 13m
American Airlines
Tue 5/56:00 pm
BUF
-
ALO
1 stop6h 49m
American Airlines
Deal found 2/25$309
This Delta deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1612:05 pm
CID
-
BUF
1 stop5h 28m
Delta
Sat 10/247:25 pm
BUF
-
CID
1 stop4h 01m
Delta
Deal found 2/23$319
This Delta deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/106:00 am
MLI
-
BUF
2 stops9h 51m
Delta
Tue 3/176:02 am
BUF
-
MLI
2 stops11h 30m
Delta
Deal found 2/25$319
This Southwest deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/225:30 am
DSM
-
BUF
1 stop3h 50m
Southwest
Mon 4/2712:40 pm
BUF
-
DSM
2 stops11h 25m
Southwest
Deal found 2/25$322

Find flight deals from Iowa to Buffalo

Keep the following information in mind while searching for Iowa to Buffalo flight deals. Data was last updated February 26, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$279
(American Airlines)

One-way from

$143
(Delta)

Popular in

February

Cheapest in

October

Average price

$646
Provider with most accurate pricing for Des Moines-Buffalo flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Buffalo flights.
Search Deals
From Iowa to Buffalo
Search Deals
One-way flight from Iowa to Buffalo
Search Deals
Highest demand for flights based on searches. 22% potential increase in price ($121 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($24 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 26, 2026.
Use the filters below to find and compare flights from Iowa to Buffalo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cedar RapidsBuffalo

CID - BUF

CIDBUF

Cedar Rapids

Tue 3/10

7:07 am-3:25 pm

2 stops7h 18m

Buffalo

Sat 3/14

6:00 am-9:13 am

1 stop4h 13m

$284

Cedar RapidsBuffalo

CID - BUF

CIDBUF

Cedar Rapids

Thu 5/21

10:00 am-4:46 pm

1 stop5h 46m

Buffalo

Sun 5/24

7:00 am-10:33 am

1 stop4h 33m

$285

OmahaBuffalo

OMA - BUF

OMABUF

Omaha Eppley Airfield

Wed 5/13

5:12 pm-11:32 pm

1 stop5h 20m

Buffalo

Tue 5/19

5:41 pm-11:15 pm

1 stop6h 34m

$285

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Wed 4/22

12:00 pm-5:30 pm

1 stop4h 30m

Buffalo

Mon 4/27

6:00 am-10:26 am

1 stop5h 26m

$300

MolineBuffalo

MLI - BUF

MLIBUF

Moline Quad-City

Wed 3/11

3:31 pm-10:41 pm

1 stop6h 10m

Buffalo

Sun 3/15

5:59 pm-11:37 pm

1 stop6h 38m

$304

WaterlooBuffalo

ALO - BUF

ALOBUF

Waterloo

Thu 4/30

2:23 pm-9:36 pm

1 stop6h 13m

Buffalo

Tue 5/5

6:00 pm-11:49 pm

1 stop6h 49m

$309

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Thu 4/9

5:25 am-10:15 am

1 stop3h 50m

Buffalo

Mon 4/13

8:00 pm-11:05 pm

1 stop4h 05m

$328

Cedar RapidsBuffalo

CID - BUF

CIDBUF

Cedar Rapids

Tue 4/28

8:00 am-1:13 pm

1 stop4h 13m

Buffalo

Sat 5/2

11:02 am-1:58 pm

1 stop3h 56m

$339

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Fri 3/27

5:20 pm-11:46 pm

1 stop5h 26m

Buffalo

Wed 4/1

6:15 am-9:46 am

1 stop4h 31m

$339

MolineBuffalo

MLI - BUF

MLIBUF

Moline Quad-City

Sat 5/2

3:47 pm-9:01 pm

1 stop4h 14m

Buffalo

Wed 5/6

7:00 am-12:53 pm

1 stop6h 53m

$339

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/24

Showing 1-10 of 56 resultsSorted by cheapest first
1
2
3
...
6

Best time to book a flight from Iowa to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Buffalo

What is the cheapest month to book a flight from Iowa to Buffalo?

Currently, June is the cheapest month in which you can book a flight from Iowa to Buffalo (average of $100). Flying from Iowa to Buffalo in February is currently the most expensive (average of $304). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Iowa to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Buffalo from Iowa?

    Most people fly into Buffalo (BUF) if they book a flight to Buffalo from Iowa. Buffalo is conveniently located just 8.3 mi from Buffalo’s city center.

  • How long is the flight from Iowa to Buffalo?

    Airlines like American Airlines, United Airlines, and Delta fly from Iowa to Buffalo in about 5h 20m. The time it takes to get you to your destination can typically vary by up to 1h 58m. There are 885 mi between Iowa and Buffalo. This flight may include one or multiple stops.

  • What are the most popular routes from Iowa to Buffalo?

    While some choose either Des Moines - Buffalo or Moline Quad-City - Buffalo, Omaha Eppley Airfield - Buffalo is the most popular route from Iowa to Buffalo.

  • Can I find deals for flights from Iowa to Buffalo that include hotel bookings?

    Yes. In addition to deals on Iowa to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Buffalo.

  • Can I find deals for business class flights from Iowa to Buffalo?

    Yes. Cheapflights offers flight deals from Iowa to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to Buffalo?

    Currently, June is the cheapest month in which you can book a flight from Iowa to Buffalo (average of $100). Flying from Iowa to Buffalo in February is currently the most expensive (average of $304). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Lockport
Cheektowaga
Batavia
Williamsville
Orchard Park
Eden
Amherst
West Seneca

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Iowa to Buffalo

See prices for flight routes from nearby airports that may be better suited for you.
San Francisco to John F Kennedy Intl flights
San Francisco to Newark flights
San Francisco to LaGuardia flights
Los Angeles to John F Kennedy Intl flights
Dallas/Fort Worth to John F Kennedy Intl flights
Dallas/Fort Worth to Newark flights
Dallas/Fort Worth to LaGuardia flights
O'Hare Intl to John F Kennedy Intl flights
Fort Lauderdale to Newark flights
Los Angeles to Newark flights
Miami to John F Kennedy Intl flights
Orlando to John F Kennedy Intl flights
Los Angeles to LaGuardia flights
Fort Lauderdale to John F Kennedy Intl flights
Atlanta to LaGuardia flights
Atlanta to John F Kennedy Intl flights
Miami to Newark flights
Miami to LaGuardia flights
Fort Lauderdale to LaGuardia flights
O'Hare Intl to LaGuardia flights
O'Hare Intl to Newark flights
Hobby to Newark flights
Atlanta to Newark flights
Hobby to John F Kennedy Intl flights
Tampa to Newark flights
Raleigh to John F Kennedy Intl flights
Hobby to LaGuardia flights
Denver to LaGuardia flights
Orlando to LaGuardia flights
Austin to John F Kennedy Intl flights
West Palm Beach to Newark flights
Orlando to Newark flights
Raleigh to LaGuardia flights
Charlotte to John F Kennedy Intl flights
Seattle to Newark flights
Denver to Newark flights
George Bush Intcntl to John F Kennedy Intl flights
San Jose to Newark flights
San Jose to John F Kennedy Intl flights
Seattle to John F Kennedy Intl flights
George Bush Intcntl to Newark flights
Minneapolis to John F Kennedy Intl flights
Detroit to John F Kennedy Intl flights
Austin to Newark flights
Oakland to Newark flights
Minneapolis to LaGuardia flights
Denver to John F Kennedy Intl flights
West Palm Beach to John F Kennedy Intl flights
Burbank to LaGuardia flights
Ontario to Newark flights

Top 3 airlines flying from Iowa to Buffalo

Discover the top 3 airlines that operate flights from Iowa to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 26, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$148Average$331FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$238Average$326FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$278Average$453FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.