$136+ Cheap flights from Greenville to Buffalo (GSP - BUF)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/29. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — BUF
Apr 5 — Apr 121
Round-trip
1 adult, Economy
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Find cheap flights from Greenville to Buffalo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Greenville to Buffalo
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Best
Last-minute
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Cheapest flights from Greenville to BuffaloExplore the most affordable flight options available from Greenville to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 6, 2026.
Explore the most affordable flight options available from Greenville to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 6, 2026.
This Delta deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/305:40 am
GSP
- BUF
1 stop5h 21m
Delta
Wed 4/16:02 am
BUF
- GSP
1 stop4h 57m
Delta
Deal found 3/4![Delta logo]()
$286
This Delta deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/256:22 pm
GSP
- BUF
1 stop4h 17m
Delta
Sat 5/93:52 pm
BUF
- GSP
1 stop5h 46m
Delta
Deal found 3/1![Delta logo]()
$297
This American Airlines deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/236:00 am
GSP
- BUF
1 stop4h 58m
American Airlines
Thu 3/265:30 am
BUF
- GSP
1 stop5h 14m
American Airlines
Deal found 3/2![American Airlines logo]()
$301
This American Airlines deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/255:20 am
GSP
- BUF
2 stops6h 38m
American Airlines
Sat 5/96:00 am
BUF
- GSP
1 stop4h 11m
American Airlines
Deal found 3/1![American Airlines logo]()
$302
This American Airlines deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/255:20 am
GSP
- BUF
2 stops6h 38m
American Airlines
Sat 4/255:42 pm
BUF
- GSP
2 stops6h 15m
American Airlines
Deal found 3/1![American Airlines logo]()
$307
This American Airlines deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/146:00 am
GSP
- BUF
1 stop5h 14m
American Airlines
Sat 5/1612:29 pm
BUF
- GSP
1 stop6h 14m
American Airlines
Deal found 3/2![American Airlines logo]()
$316
This Delta deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/25:40 am
GSP
- BUF
1 stop5h 21m
Delta
Sun 5/106:15 am
BUF
- GSP
1 stop5h 50m
Delta
Deal found 3/2![Delta logo]()
$332
This Southwest deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/210:45 am
GSP
- BUF
2 stops7h 15m
Southwest
Sun 5/108:55 am
BUF
- GSP
1 stop4h 15m
Southwest
Deal found 3/3![Southwest logo]()
$337
Best flights from Greenville to BuffaloDiscover carefully curated flight deals from Greenville to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 6, 2026.
Discover carefully curated flight deals from Greenville to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 6, 2026.
This Delta deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/26:22 pm
GSP
- BUF
1 stop4h 17m
Delta
Sun 5/106:15 am
BUF
- GSP
1 stop5h 50m
Delta
Deal found 3/4![Delta logo]()
$352
This United Airlines deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/3110:33 am
GSP
- BUF
1 stop3h 44m
United Airlines
Wed 4/17:00 am
BUF
- GSP
1 stop4h 54m
United Airlines
Deal found 3/2![United Airlines logo]()
$367
This Southwest deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/191:55 pm
GSP
- BUF
1 stop6h 35m
Southwest
Mon 3/235:55 pm
BUF
- GSP
1 stop3h 55m
Southwest
Deal found 3/1![Southwest logo]()
$374
This Delta deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/295:05 pm
GSP
- BUF
1 stop6h 53m
Delta
Fri 7/312:09 pm
BUF
- GSP
1 stop4h 04m
Delta
Deal found 3/1![Delta logo]()
$367
This Southwest deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/261:55 pm
GSP
- BUF
2 stops8h 40m
Southwest
Mon 6/292:50 pm
BUF
- GSP
1 stop6h 45m
Southwest
Deal found 3/5![Southwest logo]()
$412
This Delta deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/236:14 pm
GSP
- BUF
1 stop4h 41m
Delta
Thu 3/266:02 am
BUF
- GSP
1 stop4h 57m
Delta
Deal found 3/5![Delta logo]()
$384
This Southwest deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/2712:25 pm
GSP
- BUF
2 stops8h 50m
Southwest
Mon 3/3012:05 pm
BUF
- GSP
2 stops10h 40m
Southwest
Deal found 3/2![Southwest logo]()
$414
This Delta deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/206:05 am
GSP
- BUF
1 stop8h 14m
Delta
Sun 3/296:02 am
BUF
- GSP
1 stop4h 56m
Delta
Deal found 3/1![Delta logo]()
$416
Last-minute flights from Greenville to BuffaloDiscover last-minute flight deals from Greenville to Buffalo. Data last updated March 6, 2026 and is based on user searches.
Discover last-minute flight deals from Greenville to Buffalo. Data last updated March 6, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/236:00 am
GSP
- BUF
1 stop4h 58m
American Airlines
Thu 3/265:30 am
BUF
- GSP
1 stop5h 14m
American Airlines
Deal found 3/2![American Airlines logo]()
$301
This American Airlines deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/276:53 pm
GSP
- BUF
1 stop3h 57m
American Airlines
Mon 3/304:04 pm
BUF
- GSP
1 stop6h 04m
American Airlines
Deal found 3/2![American Airlines logo]()
$344
This Delta deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/305:40 am
GSP
- BUF
1 stop5h 21m
Delta
Wed 4/16:02 am
BUF
- GSP
1 stop4h 57m
Delta
Deal found 3/4![Delta logo]()
$286
This Delta deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/17:30 am
GSP
- BUF
1 stop4h 14m
Delta
Mon 4/64:47 pm
BUF
- GSP
1 stop5h 05m
Delta
Deal found 3/3![Delta logo]()
$355
This American Airlines deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/66:00 am
GSP
- BUF
1 stop4h 58m
American Airlines
Fri 4/107:28 pm
BUF
- GSP
1 stop4h 29m
American Airlines
Deal found 3/2![American Airlines logo]()
$362
This Delta deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/256:22 pm
GSP
- BUF
1 stop4h 17m
Delta
Sat 5/93:52 pm
BUF
- GSP
1 stop5h 46m
Delta
Deal found 3/1![Delta logo]()
$297
This American Airlines deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/255:20 am
GSP
- BUF
2 stops6h 38m
American Airlines
Sat 5/96:00 am
BUF
- GSP
1 stop4h 11m
American Airlines
Deal found 3/1![American Airlines logo]()
$302
This American Airlines deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/255:20 am
GSP
- BUF
2 stops6h 38m
American Airlines
Sat 4/255:42 pm
BUF
- GSP
2 stops6h 15m
American Airlines
Deal found 3/1![American Airlines logo]()
$307
One-way flights from Greenville to BuffaloSearch for one-way flight options from Greenville to Buffalo. Find affordable one-way fares based on user searches. Data last updated March 6, 2026.
Search for one-way flight options from Greenville to Buffalo. Find affordable one-way fares based on user searches. Data last updated March 6, 2026.
This American Airlines deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/2510:40 am
GSP
- BUF
1 stop5h 14m
American Airlines
Deal found 3/4![American Airlines logo]()
$136
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/48:18 pm
GSP
- BUF
2 stops39h 55m
Multiple Airlines
Deal found 3/3![Multiple Airlines logo]()
$139
This United Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/1512:07 pm
GSP
- BUF
2 stops6h 42m
United Airlines
Deal found 3/5![United Airlines logo]()
$141
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/178:18 pm
GSP
- BUF
2 stops15h 55m
Multiple Airlines
Deal found 3/3![Multiple Airlines logo]()
$143
This Delta deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/16:14 pm
GSP
- BUF
1 stop4h 41m
Delta
Deal found 3/3![Delta logo]()
$146
This Delta deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/255:40 am
GSP
- BUF
1 stop5h 21m
Delta
Deal found 3/1![Delta logo]()
$149
This United Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/27:42 pm
GSP
- BUF
1 stop4h 08m
United Airlines
Deal found 3/3![United Airlines logo]()
$151
This Delta deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/185:40 am
GSP
- BUF
1 stop5h 21m
Delta
Deal found 3/4![Delta logo]()
$159
This deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/25:40 am
GSP
- BUF
1 stop5h 21m
Delta
Deal found 3/4![Delta logo]()
$161
This United Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/256:30 am
GSP
- BUF
2 stops7h 44m
United Airlines
Deal found 3/3![United Airlines logo]()
$176
Find flight deals from Greenville to Buffalo
Discover tips and strategies to find the most affordable flight options for your journey from Greenville (GSP) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 6, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $286 (Delta) |
One-way from | $136 (American Airlines) |
Popular in | December |
Cheapest in | March |
Average price | $242 |
Cheapflights Fare Finder
Customize your flight search to find flights from Greenville to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 6, 2026.
Use the filters below to find and compare flights from Greenville to Buffalo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
GreenvilleBuffalo
GSP - BUF
GSPBUF
Greenville
Sat 5/2
6:22 pm-10:39 pm
1 stop4h 17m
Buffalo
Sun 5/10
6:15 am-12:05 pm
1 stop5h 50m
$352
Quickest round-trip
GreenvilleBuffalo
GSP - BUF
GSPBUF
Greenville
Tue 3/31
10:33 am-2:17 pm
1 stop3h 44m
Buffalo
Wed 4/1
7:00 am-11:54 am
1 stop4h 54m
$367
GreenvilleBuffalo
GSP - BUF
GSPBUF
Greenville
Mon 6/29
5:05 pm-11:58 pm
1 stop6h 53m
Buffalo
Fri 7/3
12:09 pm-4:13 pm
1 stop4h 04m
$367
GreenvilleBuffalo
GSP - BUF
GSPBUF
Greenville
Thu 3/19
1:55 pm-8:30 pm
1 stop6h 35m
Buffalo
Mon 3/23
5:55 pm-9:50 pm
1 stop3h 55m
$374
GreenvilleBuffalo
GSP - BUF
GSPBUF
Greenville
Mon 3/23
6:14 pm-10:55 pm
1 stop4h 41m
Buffalo
Thu 3/26
6:02 am-10:59 am
1 stop4h 57m
$384
GreenvilleBuffalo
GSP - BUF
GSPBUF
Greenville
Fri 6/26
1:55 pm-10:35 pm
2 stops8h 40m
Buffalo
Mon 6/29
2:50 pm-9:35 pm
1 stop6h 45m
$412
GreenvilleBuffalo
GSP - BUF
GSPBUF
Greenville
Fri 3/27
12:25 pm-9:15 pm
2 stops8h 50m
Buffalo
Mon 3/30
12:05 pm-10:45 pm
2 stops10h 40m
$414
GreenvilleBuffalo
GSP - BUF
GSPBUF
Greenville
Fri 3/20
6:05 am-2:19 pm
1 stop8h 14m
Buffalo
Sun 3/29
6:02 am-10:58 am
1 stop4h 56m
$416
Cheapest one-way
GreenvilleBuffalo
GSP - BUF
GSPBUF
Greenville
Wed 4/29
6:59 pm-11:31 pm
1 stop4h 32m
$136
GreenvilleBuffalo
GSP - BUF
GSPBUF
Greenville
Wed 4/29
6:45 am-2:35 pm
2 stops7h 50m
$141
Showing 1-10 of 19 resultsSorted by cheapest first
Compare providers for flights from Greenville to Buffalo
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Greenville to Buffalo in March.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Greenville-Buffalo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Greenville-Buffalo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Greenville-Buffalo flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Greenville-Buffalo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Greenville-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Greenville to Buffalo
Have a flexible travel schedule? Discover the best time to fly to Buffalo from Greenville with our price prediction graph.
GSP-BUF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Greenville to Buffalo
Reviews of airlines servicing Buffalo
Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated March 6, 2026.
Peruse reviews from past customers who have flown with Southwest, Delta, and American Airlines from Greenville to Buffalo to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.5
Crew
8.6
Comfort
8.0
Food
7.0
Overall
8.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Entertainment
7.5
Crew
8.6
Comfort
8.0
Food
7.0
Overall
8.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Entertainment
7.5
Crew
8.6
Comfort
8.0
Food
7.0
Overall
8.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Entertainment
7.5
Crew
8.6
Comfort
8.0
Food
7.0
Overall
8.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Related info for your journey
Find useful and relevant information for your journey from Greenville to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Buffalo?
Book flights to Buffalo if you plan to visit one of these locationsLockport
Cheektowaga
Batavia
Williamsville
Orchard Park
Eden
Amherst
West Seneca
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Other flights to Buffalo
Explore flights to Buffalo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on March 6, 2026.
Complete your trip
Complete your trip to Buffalo by adding a car rental and/or hotel reservation to your travel itinerary.
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Greenville and Buffalo flights
Browse other Greenville and Buffalo flight options. Last updated on March 6, 2026.
Other flights from Greenville
Browse through other flights departing from Greenville. Flights are based on user searches made on Cheapflights and were last updated on March 6, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Greenville to Buffalo
Discover the top 3 airlines that operate flights from Greenville to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 6, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$216 | Average$311 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$236 | Average$346 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$277 | Average$336 | FlexibilityNo cancel fee | On-time63% |