$225+ Cheap flights from Portland, ME (PWM) to Biloxi, MS
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/16. Fares are subject to change and may not be available on all flights or dates of travel.
PWM — MSY
Sep 18 — Sep 251
Round-trip
1 adult, Economy
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Find cheap flights from Portland to Biloxi with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Portland to Biloxi
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Best
Last-minute
One-way
Cheapest flights from Portland to BiloxiExplore the most affordable flight options available from Portland to Biloxi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 19, 2026.
Explore the most affordable flight options available from Portland to Biloxi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 19, 2026.
This Delta deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:00 am -
1 stop8h 08m
Sat 11/146:25 am -
1 stop5h 38m
Deal found 8/17![Delta logo]()
$339
This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/117:10 am -
1 stop7h 18m
Sat 11/142:02 pm -
1 stop6h 34m
Deal found 8/18![American Airlines logo]()
$353
This American Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/185:18 pm -
1 stop6h 14m
Mon 9/211:42 pm -
1 stop7h 31m
Deal found 8/16![American Airlines logo]()
$399
This American Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/185:18 pm -
1 stop6h 14m
Fri 9/251:42 pm -
1 stop7h 31m
Deal found 8/19![American Airlines logo]()
$431
This American Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/175:18 pm -
1 stop6h 14m
Tue 9/221:42 pm -
2 stops9h 03m
Deal found 8/16![American Airlines logo]()
$438
This Delta deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/172:10 pm -
1 stop20h 06m
Tue 9/221:59 pm -
2 stops8h 57m
Deal found 8/16![Delta logo]()
$518
Best flights from Portland to BiloxiDiscover carefully curated flight deals from Portland to Biloxi that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 19, 2026.
Discover carefully curated flight deals from Portland to Biloxi that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 19, 2026.
This Delta deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:00 am -
1 stop8h 08m
Sat 11/146:25 am -
1 stop5h 38m
Deal found 8/17![Delta logo]()
$339
This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/117:10 am -
1 stop7h 18m
Sat 11/142:02 pm -
1 stop6h 34m
Deal found 8/18![American Airlines logo]()
$353
Last-minute flights from Portland to BiloxiDiscover last-minute flight deals from Portland to Biloxi. Data last updated August 19, 2026 and is based on user searches.
Discover last-minute flight deals from Portland to Biloxi. Data last updated August 19, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/245:15 am -
2 stops11h 57m
Mon 8/312:00 pm -
2 stops8h 59m
Deal found 8/19![United Airlines logo]()
$543
This American Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/241:30 pm -
2 stops10h 00m
Mon 8/311:50 pm -
1 stop7h 10m
Deal found 8/19![American Airlines logo]()
$544
This American Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/175:18 pm -
1 stop6h 14m
Tue 9/221:42 pm -
1 stop7h 31m
Deal found 8/16![American Airlines logo]()
$339
This Delta deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/172:10 pm -
1 stop20h 06m
Tue 9/221:59 pm -
2 stops8h 57m
Deal found 8/16![Delta logo]()
$518
This American Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/185:18 pm -
1 stop6h 14m
Mon 9/211:42 pm -
1 stop7h 31m
Deal found 8/16![American Airlines logo]()
$399
This American Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/185:18 pm -
1 stop6h 14m
Fri 9/251:42 pm -
1 stop7h 31m
Deal found 8/19![American Airlines logo]()
$431
This Delta deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/184:45 pm -
2 stops17h 36m
Tue 9/221:59 pm -
2 stops8h 57m
Deal found 8/16![Delta logo]()
$623
This American Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/185:18 pm -
1 stop6h 14m
Sun 9/207:00 am -
2 stops7h 41m
Deal found 8/16![American Airlines logo]()
$633
One-way flights from Portland to BiloxiSearch for one-way flight options from Portland to Biloxi. Find affordable one-way fares based on user searches. Data last updated August 19, 2026.
Search for one-way flight options from Portland to Biloxi. Find affordable one-way fares based on user searches. Data last updated August 19, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/165:09 pm -
3 stops40h 42m
Deal found 8/18![Multiple Airlines logo]()
$225
This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/167:00 am -
1 stop7h 12m
Deal found 8/18![American Airlines logo]()
$235
This United Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/56:02 am -
2 stops11h 10m
Deal found 8/18![United Airlines logo]()
$240
This American Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/255:18 pm -
1 stop6h 14m
Deal found 8/16![American Airlines logo]()
$262
This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/57:05 am -
1 stop6h 10m
Deal found 8/18![American Airlines logo]()
$349
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/57:00 am -
3 stops49h 41m
Deal found 8/19![Breeze Airways logo]()
$354
This United Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/256:00 am -
3 stops32h 25m
Deal found 8/16![United Airlines logo]()
$496
This American Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/87:05 am -
1 stop7h 12m
Deal found 8/16![American Airlines logo]()
$507
This Delta deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/256:02 am -
2 stops12h 12m
Deal found 8/17![Delta logo]()
$535
Find flight deals from Portland to Biloxi
Keep the following information in mind while searching for Portland to Biloxi flight deals. Data was last updated August 19, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $339 (Delta) |
One-way from | $225 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from Portland to Biloxi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 19, 2026.
Use the filters below to find and compare flights from Portland to Biloxi that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
PortlandGulfport
PWM Portland - GPT Gulfport Biloxi Regional
PWMGPT
Portland
Wed 11/11
6:00 am-1:08 pm
1 stop8h 08m
Gulfport Biloxi Regional
Sat 11/14
6:25 am-1:03 pm
1 stop5h 38m
$339
PortlandGulfport
PWM Portland - GPT Gulfport Biloxi Regional
PWMGPT
Portland
Wed 11/11
7:10 am-1:28 pm
1 stop7h 18m
Gulfport Biloxi Regional
Sat 11/14
2:02 pm-9:36 pm
1 stop6h 34m
$353
Cheapest one-way
PortlandGulfport
PWM Portland - GPT Gulfport Biloxi Regional
PWMGPT
Portland
Wed 9/16
5:09 pm-8:51 am
3 stops40h 42m
$225
PortlandGulfport
PWM Portland - GPT Gulfport Biloxi Regional
PWMGPT
Portland
Sat 9/5
6:02 am-4:12 pm
2 stops11h 10m
$240
PortlandGulfport
PWM Portland - GPT Gulfport Biloxi Regional
PWMGPT
Portland
Wed 9/16
5:15 am-4:12 pm
2 stops11h 57m
$240
PortlandGulfport
PWM Portland - GPT Gulfport Biloxi Regional
PWMGPT
Portland
Fri 9/25
5:30 am-5:12 pm
2 stops12h 42m
$334
PortlandGulfport
PWM Portland - GPT Gulfport Biloxi Regional
PWMGPT
Portland
Tue 9/8
2:42 pm-10:30 pm
2 stops8h 48m
$334
Quickest one-way
PortlandGulfport
PWM Portland - GPT Gulfport Biloxi Regional
PWMGPT
Portland
Sat 9/5
7:05 am-12:15 pm
1 stop6h 10m
$349
PortlandGulfport
PWM Portland - GPT Gulfport Biloxi Regional
PWMGPT
Portland
Sat 9/5
7:00 am-7:41 am
3 stops49h 41m
$354
PortlandGulfport
PWM Portland - GPT Gulfport Biloxi Regional
PWMGPT
Portland
Fri 9/25
6:00 am-1:25 pm
3 stops32h 25m
$496
Showing 1-10 of 11 resultsSorted by cheapest first
Best time to book a flight from Portland to Biloxi
Have a flexible travel schedule? Discover the best time to fly to Biloxi from Portland with our price prediction graph.
PWM-GPT
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Portland to Biloxi
PWM-B1L
PWM-GPT
No data available for this route at this time. Please check back soon.
Related info for your journey
Find useful and relevant information for your journey from Portland to Biloxi. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Portland to Biloxi
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Complete your trip
Complete your trip to Biloxi by adding a car rental and/or hotel reservation to your travel itinerary.
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Portland and Biloxi flights
Browse other Portland and Biloxi flight options. Last updated on August 19, 2026.
Other flights from Portland
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Portland to Biloxi flights
Consider these flights traveling from Portland to Biloxi.
Top 4 airlines flying from Portland to Biloxi
Discover the top 4 airlines that operate flights from Portland to Biloxi. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 19, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$182 | Average$397 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$290 | Average$484 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$305 | Average$455 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$451 | Average$556 | FlexibilityNo cancel fee | On-time69% |