$156+ Cheap flights from Knoxville (TYS) to Biloxi, MS
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/28. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — MSY
Oct 16 — Oct 231
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Biloxi with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Biloxi
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Cheapest flights from Knoxville to BiloxiExplore the most affordable flight options available from Knoxville to Biloxi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2026.
Explore the most affordable flight options available from Knoxville to Biloxi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/55:37 pm -
2 stops16h 14m
Sun 11/87:45 pm -
1 stop16h 46m
Deal found 9/12![Multiple Airlines logo]()
$318
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:06 pm -
1 stop6h 53m
Wed 10/216:42 pm -
1 stop4h 13m
Deal found 9/16![American Airlines logo]()
$335
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/55:40 am -
1 stop4h 37m
Sun 11/86:26 am -
1 stop3h 28m
Deal found 9/15![Delta logo]()
$366
This Delta deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/54:11 pm -
1 stop5h 35m
Sat 11/76:26 am -
1 stop6h 05m
Deal found 9/12![Delta logo]()
$392
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:15 am -
2 stops27h 36m
Sun 10/187:45 pm -
1 stop14h 29m
Deal found 9/14![Multiple Airlines logo]()
$404
This Delta deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/105:40 am -
1 stop4h 37m
Sat 10/174:00 pm -
1 stop5h 22m
Deal found 9/12![Delta logo]()
$418
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/296:06 pm -
1 stop5h 26m
Sat 10/35:42 pm -
1 stop4h 08m
Deal found 9/14![American Airlines logo]()
$477
This American Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/107:58 pm -
1 stop5h 01m
Sat 10/176:42 pm -
1 stop4h 13m
Deal found 9/12![American Airlines logo]()
$482
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1610:26 am -
1 stop3h 45m
Tue 9/225:59 pm -
1 stop4h 56m
Deal found 9/15![Delta logo]()
$495
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/15:40 am -
1 stop4h 37m
Thu 11/56:26 am -
1 stop3h 19m
Deal found 9/14![Delta logo]()
$499
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/18:04 pm -
1 stop4h 53m
Thu 11/512:43 pm -
1 stop3h 54m
Deal found 9/14![American Airlines logo]()
$522
Best flights from Knoxville to BiloxiDiscover carefully curated flight deals from Knoxville to Biloxi that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 16, 2026.
Discover carefully curated flight deals from Knoxville to Biloxi that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 16, 2026.
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:06 pm -
1 stop6h 53m
Wed 10/216:42 pm -
1 stop4h 13m
Deal found 9/16![American Airlines logo]()
$335
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/2612:00 pm -
1 stop5h 02m
Sat 1/301:54 pm -
1 stop7h 20m
Deal found 9/15![United Airlines logo]()
$393
This Delta deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/105:40 am -
1 stop4h 37m
Sat 10/174:00 pm -
1 stop5h 22m
Deal found 9/12![Delta logo]()
$418
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/296:06 pm -
1 stop5h 26m
Sat 10/35:42 pm -
1 stop4h 08m
Deal found 9/14![American Airlines logo]()
$477
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/15:40 am -
1 stop4h 37m
Thu 11/56:26 am -
1 stop3h 19m
Deal found 9/14![Delta logo]()
$499
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/277:00 am -
1 stop7h 18m
Fri 10/304:55 pm -
2 stops22h 09m
Deal found 9/15![United Airlines logo]()
$569
Last-minute flights from Knoxville to BiloxiDiscover last-minute flight deals from Knoxville to Biloxi. Data last updated September 16, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Biloxi. Data last updated September 16, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1610:26 am -
1 stop3h 45m
Tue 9/225:59 pm -
1 stop4h 56m
Deal found 9/15![Delta logo]()
$495
This United Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1612:15 pm -
1 stop4h 57m
Tue 9/222:00 pm -
2 stops25h 58m
Deal found 9/12![United Airlines logo]()
$709
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/286:30 am -
1 stop12h 36m
Fri 10/26:46 pm -
2 stops36h 19m
Deal found 9/12![Multiple Airlines logo]()
$608
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/296:06 pm -
1 stop5h 26m
Sat 10/35:42 pm -
1 stop4h 08m
Deal found 9/14![American Airlines logo]()
$477
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2912:05 pm -
1 stop5h 07m
Sat 10/35:14 pm -
2 stops15h 31m
Deal found 9/14![United Airlines logo]()
$623
This Delta deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/105:40 am -
1 stop4h 37m
Sat 10/174:00 pm -
1 stop5h 22m
Deal found 9/12![Delta logo]()
$418
This American Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/107:58 pm -
1 stop5h 01m
Sat 10/176:42 pm -
1 stop4h 13m
Deal found 9/12![American Airlines logo]()
$482
This United Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/106:03 pm -
2 stops20h 22m
Sat 10/172:00 pm -
1 stop6h 55m
Deal found 9/12![United Airlines logo]()
$593
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:06 pm -
1 stop6h 53m
Wed 10/216:42 pm -
1 stop4h 13m
Deal found 9/16![American Airlines logo]()
$335
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:15 am -
2 stops27h 36m
Sun 10/187:45 pm -
1 stop14h 29m
Deal found 9/14![Multiple Airlines logo]()
$404
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/157:58 pm -
1 stop5h 01m
Sun 10/186:42 pm -
1 stop4h 13m
Deal found 9/14![American Airlines logo]()
$573
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/277:00 am -
1 stop7h 18m
Fri 10/304:55 pm -
2 stops22h 09m
Deal found 9/15![United Airlines logo]()
$569
One-way flights from Knoxville to BiloxiSearch for one-way flight options from Knoxville to Biloxi. Find affordable one-way fares based on user searches. Data last updated September 16, 2026.
Search for one-way flight options from Knoxville to Biloxi. Find affordable one-way fares based on user searches. Data last updated September 16, 2026.
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/285:40 am -
1 stop4h 37m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Delta logo]()
$156
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/109:36 pm -
2 stops36h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/12![Multiple Airlines logo]()
$188
This American Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/107:58 pm -
1 stop5h 01m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/12![American Airlines logo]()
$238
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/286:45 am -
2 stops13h 49m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![United Airlines logo]()
$437
Find flight deals from Knoxville to Biloxi
Keep the following information in mind while searching for Knoxville to Biloxi flight deals. Data was last updated September 16, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $318 (Kiwi.com) |
One-way from | $156 (Delta) |
Popular in | March |
Cheapest in | October |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Biloxi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 16, 2026.
Use the filters below to find and compare flights from Knoxville to Biloxi that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
KnoxvilleGulfport
TYS Knoxville McGhee Tyson - GPT Gulfport Biloxi Regional
TYSGPT
Knoxville McGhee Tyson
Wed 10/28
5:40 am-9:17 am
1 stop4h 37m
Gulfport Biloxi Regional
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$156
KnoxvilleGulfport
TYS Knoxville McGhee Tyson - GPT Gulfport Biloxi Regional
TYSGPT
Knoxville McGhee Tyson
Sat 10/10
7:58 pm-11:59 pm
1 stop5h 01m
Gulfport Biloxi Regional
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$238
KnoxvilleGulfport
TYS Knoxville McGhee Tyson - GPT Gulfport Biloxi Regional
TYSGPT
Knoxville McGhee Tyson
Wed 10/14
6:06 pm-11:59 pm
1 stop6h 53m
Gulfport Biloxi Regional
Wed 10/21
6:42 pm-11:55 pm
1 stop4h 13m
$335
KnoxvilleGulfport
TYS Knoxville McGhee Tyson - GPT Gulfport Biloxi Regional
TYSGPT
Knoxville McGhee Tyson
Sat 10/10
9:36 pm-8:51 am
3 stops36h 15m
Gulfport Biloxi Regional
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$371
KnoxvilleGulfport
TYS Knoxville McGhee Tyson - GPT Gulfport Biloxi Regional
TYSGPT
Knoxville McGhee Tyson
Tue 1/26
12:00 pm-4:02 pm
1 stop5h 02m
Gulfport Biloxi Regional
Sat 1/30
1:54 pm-10:14 pm
1 stop7h 20m
$393
KnoxvilleGulfport
TYS Knoxville McGhee Tyson - GPT Gulfport Biloxi Regional
TYSGPT
Knoxville McGhee Tyson
Sat 10/10
5:40 am-9:17 am
1 stop4h 37m
Gulfport Biloxi Regional
Sat 10/17
4:00 pm-10:22 pm
1 stop5h 22m
$418
KnoxvilleGulfport
TYS Knoxville McGhee Tyson - GPT Gulfport Biloxi Regional
TYSGPT
Knoxville McGhee Tyson
Wed 10/28
6:45 am-7:34 pm
2 stops13h 49m
Gulfport Biloxi Regional
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$437
KnoxvilleGulfport
TYS Knoxville McGhee Tyson - GPT Gulfport Biloxi Regional
TYSGPT
Knoxville McGhee Tyson
Tue 9/29
6:06 pm-10:32 pm
1 stop5h 26m
Gulfport Biloxi Regional
Sat 10/3
5:42 pm-10:50 pm
1 stop4h 08m
$477
KnoxvilleGulfport
TYS Knoxville McGhee Tyson - GPT Gulfport Biloxi Regional
TYSGPT
Knoxville McGhee Tyson
Sun 11/1
5:40 am-9:17 am
1 stop4h 37m
Gulfport Biloxi Regional
Thu 11/5
6:26 am-10:45 am
1 stop3h 19m
$499
KnoxvilleGulfport
TYS Knoxville McGhee Tyson - GPT Gulfport Biloxi Regional
TYSGPT
Knoxville McGhee Tyson
Tue 10/27
7:00 am-1:18 pm
1 stop7h 18m
Gulfport Biloxi Regional
Fri 10/30
4:55 pm-4:04 pm
2 stops22h 09m
$569
Sorted by cheapest first
Best time to book a flight from Knoxville to Biloxi
Have a flexible travel schedule? Discover the best time to fly to Biloxi from Knoxville with our price prediction graph.
TYS-GPT
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Biloxi
TYS-B1L
TYS-GPT
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing Biloxi
Get insights into the airlines that provide service to Biloxi. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Biloxi. Reviews last updated September 16, 2026.
Get a feel of what it's like to fly with Delta from Knoxville to Biloxi by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Entertainment
7.8
Overall
7.8
Comfort
7.8
Food
7.2
Crew
8.5
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Boarding
8.1
Entertainment
7.8
Overall
7.8
Comfort
7.8
Food
7.2
Crew
8.5
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Biloxi. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Complete your trip
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Knoxville and Biloxi flights
Browse other Knoxville and Biloxi flight options. Last updated on September 16, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on September 16, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Knoxville to Biloxi flights
Consider these flights traveling from Knoxville to Biloxi.
Top 4 airlines flying from Knoxville to Biloxi
Discover the top 4 airlines that operate flights from Knoxville to Biloxi. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 16, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$66 | Average$94 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$252 | Average$414 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$259 | Average$378 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$289 | Average$376 | FlexibilityNo cancel fee | On-time63% |