$172+ Cheap flights from Knoxville (TYS) to Biloxi, MS
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/12. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — MSY
May 29 — Jun 51
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Biloxi with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Biloxi
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Best
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One-way
Cheapest flights from Knoxville to BiloxiExplore the most affordable flight options available from Knoxville to Biloxi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 29, 2026.
Explore the most affordable flight options available from Knoxville to Biloxi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 29, 2026.
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/305:40 am
TYS
- GPT
1 stop4h 41m
Delta
Tue 7/76:00 pm
GPT
- TYS
1 stop4h 52m
Delta
Deal found 4/29![Delta logo]()
$347
This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/203:30 pm
TYS
- GPT
1 stop7h 17m
United Airlines
Sun 5/245:19 pm
GPT
- TYS
1 stop4h 53m
United Airlines
Deal found 4/28![United Airlines logo]()
$355
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/134:25 pm
TYS
- GPT
2 stops27h 45m
Multiple Airlines
Sun 5/177:50 pm
GPT
- TYS
1 stop20h 40m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$363
This United Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/223:25 pm
TYS
- GPT
1 stop5h 17m
United Airlines
Tue 8/252:00 pm
GPT
- TYS
1 stop6h 30m
United Airlines
Deal found 4/25![United Airlines logo]()
$384
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/275:40 am
TYS
- GPT
1 stop4h 41m
Delta
Wed 6/31:55 pm
GPT
- TYS
1 stop5h 37m
Delta
Deal found 4/29![Delta logo]()
$397
This American Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/237:59 pm
TYS
- GPT
1 stop5h 02m
American Airlines
Sat 5/306:38 pm
GPT
- TYS
1 stop4h 09m
American Airlines
Deal found 4/25![American Airlines logo]()
$426
Best flights from Knoxville to BiloxiDiscover carefully curated flight deals from Knoxville to Biloxi that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 29, 2026.
Discover carefully curated flight deals from Knoxville to Biloxi that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 29, 2026.
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/305:40 am
TYS
- GPT
1 stop4h 41m
Delta
Tue 7/76:00 pm
GPT
- TYS
1 stop4h 52m
Delta
Deal found 4/29![Delta logo]()
$347
This United Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/223:25 pm
TYS
- GPT
1 stop5h 17m
United Airlines
Tue 8/252:00 pm
GPT
- TYS
1 stop6h 30m
United Airlines
Deal found 4/25![United Airlines logo]()
$384
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/275:40 am
TYS
- GPT
1 stop4h 41m
Delta
Wed 6/31:55 pm
GPT
- TYS
1 stop5h 37m
Delta
Deal found 4/29![Delta logo]()
$397
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/135:40 am
TYS
- GPT
1 stop4h 41m
Delta
Sun 5/176:32 am
GPT
- TYS
1 stop3h 37m
Delta
Deal found 4/29![Delta logo]()
$507
This United Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/233:25 pm
TYS
- GPT
1 stop7h 20m
United Airlines
Sat 5/305:24 pm
GPT
- TYS
2 stops15h 41m
United Airlines
Deal found 4/25![United Airlines logo]()
$582
Last-minute flights from Knoxville to BiloxiDiscover last-minute flight deals from Knoxville to Biloxi. Data last updated April 29, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Biloxi. Data last updated April 29, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/295:57 pm
TYS
- GPT
1 stop7h 01m
American Airlines
Tue 5/56:03 am
GPT
- TYS
1 stop7h 19m
American Airlines
Deal found 4/28![American Airlines logo]()
$520
This Kiwi.com deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/106:30 am
TYS
- GPT
2 stops13h 40m
Multiple Airlines
Thu 5/147:50 pm
GPT
- TYS
1 stop20h 40m
Multiple Airlines
Deal found 4/25![Multiple Airlines logo]()
$494
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/134:25 pm
TYS
- GPT
2 stops27h 45m
Multiple Airlines
Sun 5/177:50 pm
GPT
- TYS
1 stop20h 40m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$363
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/131:59 pm
TYS
- GPT
1 stop4h 15m
Delta
Sun 5/176:32 am
GPT
- TYS
1 stop5h 38m
Delta
Deal found 4/27![Delta logo]()
$447
This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/203:30 pm
TYS
- GPT
1 stop7h 17m
United Airlines
Sun 5/245:19 pm
GPT
- TYS
1 stop4h 53m
United Airlines
Deal found 4/28![United Airlines logo]()
$355
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/228:35 am
TYS
- GPT
1 stop5h 34m
Delta
Sun 5/246:32 am
GPT
- TYS
1 stop3h 37m
Delta
Deal found 4/28![Delta logo]()
$476
This American Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/237:59 pm
TYS
- GPT
1 stop5h 02m
American Airlines
Sat 5/306:38 pm
GPT
- TYS
1 stop4h 09m
American Airlines
Deal found 4/25![American Airlines logo]()
$426
This United Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/233:25 pm
TYS
- GPT
1 stop7h 20m
United Airlines
Sat 5/305:24 pm
GPT
- TYS
2 stops15h 41m
United Airlines
Deal found 4/25![United Airlines logo]()
$582
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/275:40 am
TYS
- GPT
1 stop4h 41m
Delta
Wed 6/31:55 pm
GPT
- TYS
1 stop5h 37m
Delta
Deal found 4/29![Delta logo]()
$397
One-way flights from Knoxville to BiloxiSearch for one-way flight options from Knoxville to Biloxi. Find affordable one-way fares based on user searches. Data last updated April 29, 2026.
Search for one-way flight options from Knoxville to Biloxi. Find affordable one-way fares based on user searches. Data last updated April 29, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1212:56 pm
TYS
- GPT
2 stops43h 45m
Multiple Airlines
Deal found 4/28![Multiple Airlines logo]()
$172
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/125:30 am
TYS
- GPT
1 stop5h 05m
Delta
Deal found 4/28![Delta logo]()
$206
This Kiwi.com deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/101:02 pm
TYS
- GPT
2 stops31h 08m
Multiple Airlines
Deal found 4/25![Multiple Airlines logo]()
$216
This American Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/107:59 pm
TYS
- GPT
1 stop5h 02m
American Airlines
Deal found 4/25![American Airlines logo]()
$219
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/1310:05 am
TYS
- GPT
1 stop4h 28m
Delta
Deal found 4/28![Delta logo]()
$236
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/132:56 pm
TYS
- GPT
3 stops17h 45m
Multiple Airlines
Deal found 4/28![Multiple Airlines logo]()
$239
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/1611:56 am
TYS
- GPT
2 stops32h 14m
Multiple Airlines
Deal found 4/28![Multiple Airlines logo]()
$242
This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/167:05 am
TYS
- GPT
1 stop7h 16m
United Airlines
Deal found 4/28![United Airlines logo]()
$380
This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/126:30 am
TYS
- GPT
2 stops14h 12m
United Airlines
Deal found 4/28![United Airlines logo]()
$477
Find flight deals from Knoxville to Biloxi
Keep the following information in mind while searching for Knoxville to Biloxi flight deals. Data was last updated April 29, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $347 (Delta) |
One-way from | $172 (Kiwi.com) |
Popular in | March |
Cheapest in | June |
Average price | $456 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Biloxi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 29, 2026.
Use the filters below to find and compare flights from Knoxville to Biloxi that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleGulfport
TYS - GPT
TYSGPT
Knoxville McGhee Tyson
Tue 6/30
5:40 am-9:21 am
1 stop4h 41m
Gulfport Biloxi Regional
Tue 7/7
6:00 pm-11:52 pm
1 stop4h 52m
$347
KnoxvilleGulfport
TYS - GPT
TYSGPT
Knoxville McGhee Tyson
Sat 8/22
3:25 pm-7:42 pm
1 stop5h 17m
Gulfport Biloxi Regional
Tue 8/25
2:00 pm-9:30 pm
1 stop6h 30m
$384
KnoxvilleGulfport
TYS - GPT
TYSGPT
Knoxville McGhee Tyson
Wed 5/27
5:40 am-9:21 am
1 stop4h 41m
Gulfport Biloxi Regional
Wed 6/3
1:55 pm-8:32 pm
1 stop5h 37m
$397
Quickest round-trip
KnoxvilleGulfport
TYS - GPT
TYSGPT
Knoxville McGhee Tyson
Wed 5/13
5:40 am-9:21 am
1 stop4h 41m
Gulfport Biloxi Regional
Sun 5/17
6:32 am-11:09 am
1 stop3h 37m
$507
KnoxvilleGulfport
TYS - GPT
TYSGPT
Knoxville McGhee Tyson
Sat 5/23
3:25 pm-9:45 pm
1 stop7h 20m
Gulfport Biloxi Regional
Sat 5/30
5:24 pm-10:05 am
2 stops15h 41m
$582
Cheapest one-way
KnoxvilleGulfport
TYS - GPT
TYSGPT
Knoxville McGhee Tyson
Wed 8/12
12:56 pm-7:41 am
2 stops43h 45m
$172
KnoxvilleGulfport
TYS - GPT
TYSGPT
Knoxville McGhee Tyson
Wed 6/10
1:02 pm-7:10 pm
2 stops31h 08m
$216
Quickest one-way
KnoxvilleGulfport
TYS - GPT
TYSGPT
Knoxville McGhee Tyson
Sun 6/7
7:46 pm-10:17 pm
1 stop3h 31m
$236
KnoxvilleGulfport
TYS - GPT
TYSGPT
Knoxville McGhee Tyson
Thu 8/13
10:05 am-1:33 pm
1 stop4h 28m
$236
KnoxvilleGulfport
TYS - GPT
TYSGPT
Knoxville McGhee Tyson
Wed 8/12
6:30 am-7:42 pm
2 stops14h 12m
$477
Showing 1-10 of 12 resultsSorted by cheapest first
Best time to book a flight from Knoxville to Biloxi
Have a flexible travel schedule? Discover the best time to fly to Biloxi from Knoxville with our price prediction graph.
TYS-GPT
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Biloxi
TYS-B1L
TYS-GPT
How much does it cost to fly round-trip from Knoxville to Biloxi?
Reviews of airlines servicing Biloxi
Get insights into the airlines that provide service to Biloxi. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Biloxi. Reviews last updated April 29, 2026.
Get a feel of what it's like to fly with Delta and American Airlines from Knoxville to Biloxi by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.5
Entertainment
7.8
Food
7.2
Boarding
8.1
Comfort
7.9
Overall
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Crew
8.5
Entertainment
7.8
Food
7.2
Boarding
8.1
Comfort
7.9
Overall
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Crew
8.5
Entertainment
7.8
Food
7.2
Boarding
8.1
Comfort
7.9
Overall
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Biloxi. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Complete your trip
Complete your trip to Biloxi by adding a car rental and/or hotel reservation to your travel itinerary.
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Knoxville and Biloxi flights
Browse other Knoxville and Biloxi flight options. Last updated on April 29, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on April 29, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Knoxville to Biloxi flights
Consider these flights traveling from Knoxville to Biloxi.
Top 4 airlines flying from Knoxville to Biloxi
Discover the top 4 airlines that operate flights from Knoxville to Biloxi. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 29, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$65 | Average$88 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$209 | Average$391 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$233 | Average$366 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$294 | Average$376 | FlexibilityNo cancel fee | On-time63% |