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Biloxi

$321+ Cheap flights from Knoxville (TYS) to Biloxi, MS

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/8. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — MSY
Sep 3 — Sep 101
Thu 9/3
Thu 9/10
1 adult, Economy
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Cheap flight deals from Knoxville to Biloxi

Cheapest flights from Knoxville to Biloxi
Explore the most affordable flight options available from Knoxville to Biloxi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 4, 2026.

This Kiwi.com deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/89:28 pm
TYS
-
GPT
1 stop12h 23m
Multiple Airlines
Mon 10/126:46 pm
GPT
-
TYS
1 stop19h 28m
Multiple Airlines
Deal found 8/2$321
This Delta deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/16:12 pm
TYS
-
GPT
1 stop5h 09m
Delta
Tue 9/84:00 pm
GPT
-
TYS
1 stop5h 27m
Delta
Deal found 8/2$357
This United Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/277:15 am
TYS
-
GPT
1 stop7h 09m
United Airlines
Mon 8/312:00 pm
GPT
-
TYS
1 stop6h 45m
United Airlines
Deal found 7/30$384
This American Airlines deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:06 pm
TYS
-
GPT
1 stop6h 53m
American Airlines
Mon 11/25:39 pm
GPT
-
TYS
1 stop4h 09m
American Airlines
Deal found 8/1$397
This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/174:22 pm
TYS
-
GPT
1 stop7h 08m
American Airlines
Sun 8/235:50 pm
GPT
-
TYS
1 stop5h 09m
American Airlines
Deal found 7/30$427
This Delta deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/316:12 pm
TYS
-
GPT
1 stop5h 09m
Delta
Mon 9/76:00 pm
GPT
-
TYS
1 stop4h 52m
Delta
Deal found 8/3$458
This Kiwi.com deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/216:30 am
TYS
-
GPT
1 stop12h 36m
Multiple Airlines
Fri 9/256:46 pm
GPT
-
TYS
2 stops38h 18m
Multiple Airlines
Deal found 7/31$459
This Delta deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/16:00 am
TYS
-
GPT
1 stop4h 19m
Delta
Tue 8/410:01 am
GPT
-
TYS
1 stop4h 29m
Delta
Deal found 7/30$465
This American Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/47:25 pm
TYS
-
GPT
1 stop4h 05m
American Airlines
Sun 9/67:05 am
GPT
-
TYS
1 stop7h 08m
American Airlines
Deal found 7/31$504
This American Airlines deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/1310:08 am
TYS
-
GPT
1 stop4h 09m
American Airlines
Sat 8/156:32 am
GPT
-
TYS
1 stop5h 59m
American Airlines
Deal found 8/3$510

Find flight deals from Knoxville to Biloxi

Keep the following information in mind while searching for Knoxville to Biloxi flight deals. Data was last updated August 4, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$321
(Kiwi.com)

Popular in

March

Cheapest in

September

Average price

$403
Provider with most accurate pricing for Knoxville McGhee Tyson-Gulfport Biloxi Regional flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Gulfport Biloxi Regional flights.
Search Deals
From Knoxville McGhee Tyson to Biloxi
Search Deals
Highest demand for flights based on searches. 38% potential increase in price ($328 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 23% potential price decrease ($101 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in August 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Biloxi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 4, 2026.
Use the filters below to find and compare flights from Knoxville to Biloxi that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Fri 10/30

6:06 pm-11:59 pm

1 stop6h 53m

Gulfport Biloxi Regional

Mon 11/2

5:39 pm-10:48 pm

1 stop4h 09m

$397

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Thu 8/27

3:40 pm-7:38 pm

1 stop4h 58m

Gulfport Biloxi Regional

Mon 8/31

2:00 pm-9:45 pm

1 stop6h 45m

$418

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Mon 8/17

4:22 pm-10:30 pm

1 stop7h 08m

Gulfport Biloxi Regional

Sun 8/23

5:50 pm-11:59 pm

1 stop5h 09m

$427

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Tue 9/1

6:00 am-9:15 am

1 stop4h 15m

Gulfport Biloxi Regional

Mon 9/7

6:00 pm-11:52 pm

1 stop4h 52m

$458

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Mon 8/17

5:40 am-9:15 am

1 stop4h 35m

Gulfport Biloxi Regional

Fri 8/21

1:48 pm-6:52 pm

1 stop4h 04m

$519
Quickest round-trip

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Fri 9/4

7:25 pm-10:30 pm

1 stop4h 05m

Gulfport Biloxi Regional

Mon 9/7

5:45 pm-10:58 pm

1 stop4h 13m

$526

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/1

Sorted by cheapest first

Best time to book a flight from Knoxville to Biloxi

Have a flexible travel schedule? Discover the best time to fly to Biloxi from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Biloxi

What is the cheapest time of day to fly from TYS to B1L?

Find hourly flight availability from Knoxville to Biloxi. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 4, 2026.

When flying from Knoxville to Biloxi, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

How much does it cost to fly round-trip from Knoxville to Biloxi?

Airfare is typical for this route at the moment.
Knoxville to Biloxi flights typically cost between $308 and $527 in October.
The cheapest round-trip price found within the last 5 days was $321 on Multiple Airlines (Oct 8-Oct 12).

Reviews of airlines servicing Biloxi

Get insights into the airlines that provide service to Biloxi. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Biloxi. Reviews last updated August 4, 2026.
Get a feel of what it's like to fly with Delta and American Airlines from Knoxville to Biloxi by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.8
Good
8,483 reviews

Food

7.2

Overall

7.8

Entertainment

7.8

Crew

8.5

Comfort

7.8

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Anonymous,May 2026

SEA - KOA

The snacks were not very good, not everyone was very friendly and professional
Delta
7.8
Good
8,483 reviews
Delta
7.8
Good
8,483 reviews

Food

7.2

Overall

7.8

Entertainment

7.8

Crew

8.5

Comfort

7.8

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Anonymous,May 2026

SEA - KOA

The snacks were not very good, not everyone was very friendly and professional
American Airlines
7.1
Good
11,842 reviews
Delta
7.8
Good
8,483 reviews

Food

7.2

Overall

7.8

Entertainment

7.8

Crew

8.5

Comfort

7.8

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Anonymous,May 2026

SEA - KOA

The snacks were not very good, not everyone was very friendly and professional

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Biloxi. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Biloxi?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to Biloxi. You should not have trouble finding flights to Biloxi from McGhee Tyson; the airport handles an average of 0 outbound flights to Biloxi per day. You should also have plenty of airline options to choose from since 4 airlines have flights from the Knoxville airport to Biloxi. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • How long is the flight from Knoxville to Biloxi?

    A quick flight from Knoxville to Biloxi can take about 4h 58m. Delta provides one of the quickest options available for as low as $418. The distance from Knoxville to Biloxi is about 474 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Knoxville to Biloxi that include hotel bookings?

    Yes. In addition to deals on Knoxville to Biloxi flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Biloxi?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Biloxi.

  • Can I find deals for business class flights from Knoxville to Biloxi?

    Yes. Cheapflights offers flight deals from Knoxville to Biloxi by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Top 4 airlines flying from Knoxville to Biloxi

Discover the top 4 airlines that operate flights from Knoxville to Biloxi. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 4, 2026.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$66Average$103FlexibilityNo cancel feeOn-time88%
American AirlinesCheapest$250Average$397FlexibilityNo cancel feeOn-time71%
DeltaCheapest$253Average$413FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$289Average$363FlexibilityNo cancel feeOn-time63%

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