$248+ Cheap flights from Portland, ME (PWM) to Biloxi, MS
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/14. Fares are subject to change and may not be available on all flights or dates of travel.
PWM — MSY
Oct 22 — Oct 291
Round-trip
1 adult, Economy
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Find cheap flights from Portland to Biloxi with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Portland to Biloxi
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Best
Last-minute
One-way
Cheapest flights from Portland to BiloxiExplore the most affordable flight options available from Portland to Biloxi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 22, 2026.
Explore the most affordable flight options available from Portland to Biloxi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 22, 2026.
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/117:10 am -
1 stop7h 08m
Sat 11/142:02 pm -
1 stop6h 34m
Deal found 9/21![American Airlines logo]()
$359
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1112:45 pm -
2 stops10h 07m
Sat 11/146:26 am -
1 stop5h 40m
Deal found 9/21![Delta logo]()
$364
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/15:45 am -
1 stop7h 28m
Sat 11/72:02 pm -
1 stop6h 34m
Deal found 9/17![American Airlines logo]()
$419
This Delta deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/612:42 pm -
2 stops9h 04m
Fri 11/131:50 pm -
2 stops9h 29m
Deal found 9/20![Delta logo]()
$429
This Delta deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/156:00 am -
1 stop8h 04m
Sun 11/226:26 am -
1 stop5h 35m
Deal found 9/20![Delta logo]()
$458
This Kiwi.com deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/63:53 pm -
2 stops52h 12m
Fri 11/136:46 pm -
1 stop22h 05m
Deal found 9/20![Multiple Airlines logo]()
$479
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/145:19 pm -
2 stops26h 46m
Sun 10/187:45 pm -
1 stop12h 23m
Deal found 9/18![Breeze Airways logo]()
$494
Best flights from Portland to BiloxiDiscover carefully curated flight deals from Portland to Biloxi that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 22, 2026.
Discover carefully curated flight deals from Portland to Biloxi that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 22, 2026.
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/117:10 am -
1 stop7h 08m
Sat 11/142:02 pm -
1 stop6h 34m
Deal found 9/21![American Airlines logo]()
$359
This Delta deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1112:45 pm -
2 stops10h 07m
Sat 11/146:26 am -
1 stop5h 40m
Deal found 9/19![Delta logo]()
$364
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/66:00 am -
2 stops11h 02m
Sat 1/91:54 pm -
2 stops30h 54m
Deal found 9/21![United Airlines logo]()
$653
This Delta deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/266:00 am -
1 stop8h 35m
Tue 3/26:00 am -
2 stops9h 59m
Deal found 9/20![Delta logo]()
$463
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals ”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/196:00 am -
1 stop8h 35m
Sun 2/282:15 pm -
1 stop7h 08m
Deal found 9/21![Delta logo]()
$603
Last-minute flights from Portland to BiloxiDiscover last-minute flight deals from Portland to Biloxi. Data last updated September 22, 2026 and is based on user searches.
Discover last-minute flight deals from Portland to Biloxi. Data last updated September 22, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:30 am -
2 stops7h 41m
Sun 10/41:59 pm -
2 stops8h 57m
Deal found 9/21![Delta logo]()
$670
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/26:00 am -
1 stop7h 55m
Sun 10/41:59 pm -
2 stops8h 57m
Deal found 9/21![Delta logo]()
$823
This Delta deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/56:02 am -
2 stops8h 09m
Tue 10/66:26 am -
1 stop5h 36m
Deal found 9/19![Delta logo]()
$722
This Delta deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/56:02 am -
2 stops8h 09m
Wed 10/71:46 pm -
2 stops8h 32m
Deal found 9/19![Delta logo]()
$728
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/145:19 pm -
2 stops26h 46m
Sun 10/187:45 pm -
1 stop12h 23m
Deal found 9/18![Breeze Airways logo]()
$494
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/167:24 pm -
1 stop5h 35m
Sun 10/186:42 pm -
1 stop15h 44m
Deal found 9/17![American Airlines logo]()
$714
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/197:24 pm -
1 stop5h 35m
Thu 10/2212:49 pm -
1 stop4h 55m
Deal found 9/17![American Airlines logo]()
$654
One-way flights from Portland to BiloxiSearch for one-way flight options from Portland to Biloxi. Find affordable one-way fares based on user searches. Data last updated September 22, 2026.
Search for one-way flight options from Portland to Biloxi. Find affordable one-way fares based on user searches. Data last updated September 22, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/145:19 pm -
2 stops26h 46m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/18![Breeze Airways logo]()
$248
This Delta deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/56:02 am -
2 stops8h 09m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/19![Delta logo]()
$364
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/1310:06 am -
3 stops57h 59m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/18![Breeze Airways logo]()
$386
This American Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/144:29 pm -
1 stop8h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/18![American Airlines logo]()
$390
This United Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/136:00 am -
2 stops32h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/18![United Airlines logo]()
$474
This United Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/45:15 am -
2 stops9h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/19![United Airlines logo]()
$515
This American Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/137:03 am -
1 stop6h 47m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/18![American Airlines logo]()
$517
This United Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:00 am -
3 stops35h 12m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/18![United Airlines logo]()
$646
Find flight deals from Portland to Biloxi
Keep the following information in mind while searching for Portland to Biloxi flight deals. Data was last updated September 22, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $359 (American Airlines) |
One-way from | $248 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from Portland to Biloxi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 22, 2026.
Use the filters below to find and compare flights from Portland to Biloxi that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
PortlandGulfport
PWM Portland - GPT Gulfport Biloxi Regional
PWMGPT
Portland
Wed 10/14
5:19 pm-7:05 pm
2 stops26h 46m
Gulfport Biloxi Regional
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$248
PortlandGulfport
PWM Portland - GPT Gulfport Biloxi Regional
PWMGPT
Portland
Wed 11/11
7:10 am-1:18 pm
1 stop7h 08m
Gulfport Biloxi Regional
Sat 11/14
2:02 pm-9:36 pm
1 stop6h 34m
$359
PortlandGulfport
PWM Portland - GPT Gulfport Biloxi Regional
PWMGPT
Portland
Mon 10/5
6:02 am-1:11 pm
2 stops8h 09m
Gulfport Biloxi Regional
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$364
PortlandGulfport
PWM Portland - GPT Gulfport Biloxi Regional
PWMGPT
Portland
Wed 11/11
12:45 pm-9:52 pm
2 stops10h 07m
Gulfport Biloxi Regional
Sat 11/14
6:26 am-1:06 pm
1 stop5h 40m
$364
PortlandGulfport
PWM Portland - GPT Gulfport Biloxi Regional
PWMGPT
Portland
Tue 10/13
10:06 am-7:05 pm
3 stops57h 59m
Gulfport Biloxi Regional
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$386
PortlandGulfport
PWM Portland - GPT Gulfport Biloxi Regional
PWMGPT
Portland
Fri 2/26
6:00 am-1:35 pm
1 stop8h 35m
Gulfport Biloxi Regional
Tue 3/2
6:00 am-4:59 pm
2 stops9h 59m
$463
PortlandGulfport
PWM Portland - GPT Gulfport Biloxi Regional
PWMGPT
Portland
Tue 10/13
6:00 am-1:25 pm
2 stops32h 25m
Gulfport Biloxi Regional
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$474
PortlandGulfport
PWM Portland - GPT Gulfport Biloxi Regional
PWMGPT
Portland
Sun 10/4
5:15 am-1:25 pm
2 stops9h 10m
Gulfport Biloxi Regional
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$515
Quickest round-trip
PortlandGulfport
PWM Portland - GPT Gulfport Biloxi Regional
PWMGPT
Portland
Tue 10/13
7:03 am-12:50 pm
1 stop6h 47m
Gulfport Biloxi Regional
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$517
PortlandGulfport
PWM Portland - GPT Gulfport Biloxi Regional
PWMGPT
Portland
Fri 2/19
6:00 am-1:35 pm
1 stop8h 35m
Gulfport Biloxi Regional
Sun 2/28
2:15 pm-10:23 pm
1 stop7h 08m
$603
Showing 1-10 of 12 resultsSorted by cheapest first
Best time to book a flight from Portland to Biloxi
Have a flexible travel schedule? Discover the best time to fly to Biloxi from Portland with our price prediction graph.
PWM-GPT
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Portland to Biloxi
PWM-B1L
PWM-GPT
No data available for this route at this time. Please check back soon.
Related info for your journey
Find useful and relevant information for your journey from Portland to Biloxi. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Portland to Biloxi
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Complete your trip
Complete your trip to Biloxi by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Portland to Biloxi by cabin class
Find flights from Portland to Biloxi, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Portland and Biloxi flights
Browse other Portland and Biloxi flight options. Last updated on September 22, 2026.
Other flights from Portland
Browse through other flights departing from Portland. Flights are based on user searches made on Cheapflights and were last updated on September 22, 2026.
Popular flight searches
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Portland to Biloxi flights
Consider these flights traveling from Portland to Biloxi.
Top 4 airlines flying from Portland to Biloxi
Discover the top 4 airlines that operate flights from Portland to Biloxi. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 22, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$183 | Average$411 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$307 | Average$457 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$361 | Average$496 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$397 | Average$556 | FlexibilityNo cancel fee | On-time69% |