$258+ Cheap flights from Portland, ME (PWM) to Biloxi, MS
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/7. Fares are subject to change and may not be available on all flights or dates of travel.
PWM — MSY
Oct 13 — Oct 201
Round-trip
1 adult, Economy
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Find cheap flights from Portland to Biloxi with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Portland to Biloxi
Cheapest
Best
Last-minute
One-way
Cheapest flights from Portland to BiloxiExplore the most affordable flight options available from Portland to Biloxi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 13, 2026.
Explore the most affordable flight options available from Portland to Biloxi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 13, 2026.
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/26:00 am -
1 stop8h 09m
Sat 12/54:00 pm -
1 stop6h 34m
Deal found 9/9![Delta logo]()
$339
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:00 am -
2 stops12h 19m
Sat 11/146:20 am -
1 stop5h 46m
Deal found 9/10![Delta logo]()
$344
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/117:10 am -
1 stop7h 08m
Sat 11/142:02 pm -
1 stop6h 34m
Deal found 9/10![American Airlines logo]()
$407
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/318:49 am -
2 stops11h 45m
Wed 11/47:00 am -
2 stops13h 51m
Deal found 9/9![United Airlines logo]()
$599
Best flights from Portland to BiloxiDiscover carefully curated flight deals from Portland to Biloxi that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 13, 2026.
Discover carefully curated flight deals from Portland to Biloxi that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 13, 2026.
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:00 am -
2 stops12h 19m
Sat 11/144:00 pm -
1 stop6h 31m
Deal found 9/9![Delta logo]()
$344
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/117:10 am -
1 stop7h 08m
Sat 11/142:02 pm -
1 stop6h 34m
Deal found 9/11![American Airlines logo]()
$407
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/212:49 pm -
2 stops10h 08m
Sat 12/56:15 am -
2 stops8h 56m
Deal found 9/9![Delta logo]()
$349
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/266:00 am -
1 stop8h 35m
Tue 3/26:00 am -
2 stops9h 59m
Deal found 9/10![Delta logo]()
$404
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/266:00 am -
1 stop8h 35m
Mon 3/12:15 pm -
1 stop7h 08m
Deal found 9/10![Delta logo]()
$498
Last-minute flights from Portland to BiloxiDiscover last-minute flight deals from Portland to Biloxi. Data last updated September 13, 2026 and is based on user searches.
Discover last-minute flight deals from Portland to Biloxi. Data last updated September 13, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/236:06 am -
2 stops11h 06m
Sun 9/2712:00 pm -
2 stops10h 28m
Deal found 9/8![United Airlines logo]()
$835
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/237:00 am -
1 stop7h 12m
Sun 9/2712:35 pm -
2 stops10h 01m
Deal found 9/8![American Airlines logo]()
$847
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/318:49 am -
2 stops11h 45m
Wed 11/47:00 am -
2 stops13h 51m
Deal found 9/9![United Airlines logo]()
$599
One-way flights from Portland to BiloxiSearch for one-way flight options from Portland to Biloxi. Find affordable one-way fares based on user searches. Data last updated September 13, 2026.
Search for one-way flight options from Portland to Biloxi. Find affordable one-way fares based on user searches. Data last updated September 13, 2026.
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/76:00 am -
2 stops11h 12m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![United Airlines logo]()
$258
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/77:00 am -
3 stops37h 05m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![Breeze Airways logo]()
$328
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/76:01 am -
1 stop8h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![Delta logo]()
$410
Find flight deals from Portland to Biloxi
Keep the following information in mind while searching for Portland to Biloxi flight deals. Data was last updated September 13, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $339 (Delta) |
One-way from | $258 (United Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Portland to Biloxi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 13, 2026.
Use the filters below to find and compare flights from Portland to Biloxi that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
PortlandGulfport
PWM Portland - GPT Gulfport Biloxi Regional
PWMGPT
Portland
Wed 10/7
6:00 am-4:12 pm
2 stops11h 12m
Gulfport Biloxi Regional
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$258
PortlandGulfport
PWM Portland - GPT Gulfport Biloxi Regional
PWMGPT
Portland
Wed 11/11
6:00 am-5:19 pm
2 stops12h 19m
Gulfport Biloxi Regional
Sat 11/14
4:00 pm-11:31 pm
1 stop6h 31m
$344
PortlandGulfport
PWM Portland - GPT Gulfport Biloxi Regional
PWMGPT
Portland
Wed 12/2
12:49 pm-9:57 pm
2 stops10h 08m
Gulfport Biloxi Regional
Sat 12/5
6:15 am-4:11 pm
2 stops8h 56m
$349
PortlandGulfport
PWM Portland - GPT Gulfport Biloxi Regional
PWMGPT
Portland
Fri 2/26
6:00 am-1:35 pm
1 stop8h 35m
Gulfport Biloxi Regional
Tue 3/2
6:00 am-4:59 pm
2 stops9h 59m
$404
PortlandGulfport
PWM Portland - GPT Gulfport Biloxi Regional
PWMGPT
Portland
Wed 11/11
7:10 am-1:18 pm
1 stop7h 08m
Gulfport Biloxi Regional
Sat 11/14
2:02 pm-9:36 pm
1 stop6h 34m
$407
Quickest round-trip
PortlandGulfport
PWM Portland - GPT Gulfport Biloxi Regional
PWMGPT
Portland
Wed 10/7
6:01 am-1:01 pm
1 stop8h 00m
Gulfport Biloxi Regional
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$410
PortlandGulfport
PWM Portland - GPT Gulfport Biloxi Regional
PWMGPT
Portland
Fri 2/26
6:00 am-1:35 pm
1 stop8h 35m
Gulfport Biloxi Regional
Mon 3/1
2:15 pm-10:23 pm
1 stop7h 08m
$498
Sorted by cheapest first
Best time to book a flight from Portland to Biloxi
Have a flexible travel schedule? Discover the best time to fly to Biloxi from Portland with our price prediction graph.
PWM-GPT
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Portland to Biloxi
PWM-B1L
PWM-GPT
No data available for this route at this time. Please check back soon.
Related info for your journey
Find useful and relevant information for your journey from Portland to Biloxi. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Portland to Biloxi
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Complete your trip
Complete your trip to Biloxi by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Portland to Biloxi by cabin class
Find flights from Portland to Biloxi, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Portland and Biloxi flights
Browse other Portland and Biloxi flight options. Last updated on September 13, 2026.
Other flights from Portland
Browse through other flights departing from Portland. Flights are based on user searches made on Cheapflights and were last updated on September 13, 2026.
Popular flight searches
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Portland to Biloxi flights
Consider these flights traveling from Portland to Biloxi.
Top 4 airlines flying from Portland to Biloxi
Discover the top 4 airlines that operate flights from Portland to Biloxi. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 13, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$183 | Average$411 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$290 | Average$488 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$305 | Average$455 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$451 | Average$556 | FlexibilityNo cancel fee | On-time69% |