$240+ Cheap flights from Portland, ME (PWM) to Biloxi, MS
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/23. Fares are subject to change and may not be available on all flights or dates of travel.
PWM — MSY
Sep 26 — Oct 31
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Portland to Biloxi with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Portland to Biloxi
Cheapest
Best
Last-minute
One-way
Cheapest flights from Portland to BiloxiExplore the most affordable flight options available from Portland to Biloxi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 27, 2026.
Explore the most affordable flight options available from Portland to Biloxi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 27, 2026.
This Delta deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:00 am -
1 stop8h 05m
Sat 11/146:20 am -
1 stop5h 46m
Deal found 8/25![Delta logo]()
$339
This American Airlines deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/117:10 am -
1 stop7h 08m
Sat 11/142:02 pm -
1 stop6h 34m
Deal found 8/23![American Airlines logo]()
$353
This American Airlines deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/197:24 pm -
1 stop5h 35m
Thu 10/2212:49 pm -
1 stop4h 55m
Deal found 8/25![American Airlines logo]()
$469
This United Airlines deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/319:46 am -
2 stops10h 48m
Wed 11/47:00 am -
2 stops15h 21m
Deal found 8/26![United Airlines logo]()
$572
This American Airlines deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/97:00 am -
1 stop7h 12m
Sun 9/137:00 am -
2 stops7h 41m
Deal found 8/25![American Airlines logo]()
$591
This United Airlines deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/196:00 am -
2 stops32h 25m
Thu 10/2212:00 pm -
2 stops10h 28m
Deal found 8/25![United Airlines logo]()
$790
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/317:05 am -
1 stop7h 12m
Tue 9/11:50 pm -
1 stop7h 10m
Deal found 8/22![American Airlines logo]()
$830
Best flights from Portland to BiloxiDiscover carefully curated flight deals from Portland to Biloxi that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 27, 2026.
Discover carefully curated flight deals from Portland to Biloxi that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 27, 2026.
This Delta deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:00 am -
1 stop8h 05m
Sat 11/146:20 am -
1 stop5h 46m
Deal found 8/26![Delta logo]()
$339
Last-minute flights from Portland to BiloxiDiscover last-minute flight deals from Portland to Biloxi. Data last updated August 27, 2026 and is based on user searches.
Discover last-minute flight deals from Portland to Biloxi. Data last updated August 27, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/317:05 am -
1 stop7h 12m
Tue 9/11:50 pm -
1 stop7h 10m
Deal found 8/22![American Airlines logo]()
$830
This United Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/319:49 am -
2 stops10h 49m
Tue 9/17:08 am -
2 stops13h 15m
Deal found 8/22![United Airlines logo]()
$841
This American Airlines deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/97:00 am -
1 stop7h 12m
Sun 9/137:00 am -
2 stops7h 41m
Deal found 8/25![American Airlines logo]()
$591
This United Airlines deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:06 am -
3 stops11h 06m
Sun 9/132:00 pm -
2 stops8h 59m
Deal found 8/25![United Airlines logo]()
$1,254
One-way flights from Portland to BiloxiSearch for one-way flight options from Portland to Biloxi. Find affordable one-way fares based on user searches. Data last updated August 27, 2026.
Search for one-way flight options from Portland to Biloxi. Find affordable one-way fares based on user searches. Data last updated August 27, 2026.
This Delta deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/236:02 am -
2 stops8h 09m
Deal found 8/24![Delta logo]()
$240
This United Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/245:15 am -
2 stops11h 57m
Deal found 8/24![United Airlines logo]()
$415
Find flight deals from Portland to Biloxi
Keep the following information in mind while searching for Portland to Biloxi flight deals. Data was last updated August 27, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $339 (Delta) |
One-way from | $240 (Delta) |
Cheapflights Fare Finder
Customize your flight search to find flights from Portland to Biloxi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 27, 2026.
Use the filters below to find and compare flights from Portland to Biloxi that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
PortlandGulfport
PWM Portland - GPT Gulfport Biloxi Regional
PWMGPT
Portland
Wed 11/11
6:00 am-1:05 pm
1 stop8h 05m
Gulfport Biloxi Regional
Sat 11/14
6:20 am-1:06 pm
1 stop5h 46m
$339
Cheapest one-way
Quickest one-way
PortlandGulfport
PWM Portland - GPT Gulfport Biloxi Regional
PWMGPT
Portland
Wed 9/23
6:02 am-1:11 pm
2 stops8h 09m
$240
PortlandGulfport
PWM Portland - GPT Gulfport Biloxi Regional
PWMGPT
Portland
Thu 9/24
5:15 am-4:12 pm
2 stops11h 57m
$415
Sorted by cheapest first
Best time to book a flight from Portland to Biloxi
Have a flexible travel schedule? Discover the best time to fly to Biloxi from Portland with our price prediction graph.
PWM-GPT
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Portland to Biloxi
PWM-B1L
PWM-GPT
No data available for this route at this time. Please check back soon.
Related info for your journey
Find useful and relevant information for your journey from Portland to Biloxi. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Other flights from Portland
Popular flights
Top destinations
Alternative routes for Portland to Biloxi
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Biloxi by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Portland to Biloxi by cabin class
Find flights from Portland to Biloxi, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Portland and Biloxi flights
Browse other Portland and Biloxi flight options. Last updated on August 27, 2026.
Other flights from Portland
Browse through other flights departing from Portland. Flights are based on user searches made on Cheapflights and were last updated on August 27, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Portland to Biloxi flights
Consider these flights traveling from Portland to Biloxi.
Top 4 airlines flying from Portland to Biloxi
Discover the top 4 airlines that operate flights from Portland to Biloxi. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 27, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$183 | Average$403 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$290 | Average$484 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$305 | Average$455 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$451 | Average$556 | FlexibilityNo cancel fee | On-time69% |