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Biloxi

$337+ Cheap flights from Portland, ME (PWM) to Biloxi, MS

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/18. Fares are subject to change and may not be available on all flights or dates of travel.
PWM — MSY
Feb 21 — Feb 281
Sat 2/21
Sat 2/28
1 adult, Economy
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Cheap flight deals from Portland to Biloxi

Cheapest flights from Portland to Biloxi
Explore the most affordable flight options available from Portland to Biloxi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 22, 2026.

This American Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/185:57 pm
PWM
-
GPT
1 stop7h 06m
American Airlines
Tue 8/256:15 am
GPT
-
PWM
1 stop6h 36m
American Airlines
Deal found 1/19$337
This American Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/175:19 pm
PWM
-
GPT
2 stops7h 38m
American Airlines
Tue 11/247:15 am
GPT
-
PWM
2 stops8h 24m
American Airlines
Deal found 1/19$446
This Delta deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/22:35 pm
PWM
-
GPT
2 stops8h 18m
Delta
Sun 2/84:00 pm
GPT
-
PWM
1 stop5h 27m
Delta
Deal found 1/21$459
This American Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/227:00 am
PWM
-
GPT
1 stop7h 19m
American Airlines
Sun 1/251:45 pm
GPT
-
PWM
1 stop7h 22m
American Airlines
Deal found 1/21$469
This American Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/27:00 am
PWM
-
GPT
1 stop7h 19m
American Airlines
Sun 2/81:45 pm
GPT
-
PWM
1 stop7h 22m
American Airlines
Deal found 1/21$472
This Delta deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/226:00 am
PWM
-
GPT
2 stops12h 15m
Delta
Sun 1/252:40 pm
GPT
-
PWM
1 stop6h 47m
Delta
Deal found 1/21$474
This American Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/2312:46 pm
PWM
-
GPT
2 stops10h 55m
American Airlines
Sun 1/251:45 pm
GPT
-
PWM
1 stop7h 22m
American Airlines
Deal found 1/20$541

Find flight deals from Portland to Biloxi

Keep the following information in mind while searching for Portland to Biloxi flight deals. Data was last updated January 22, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

Expedia
3 stars

Round-trip from

$459
(Delta)
Provider with most accurate pricing for Portland-Gulfport Biloxi Regional flight deals.
Search Deals
Provider most trusted by Cheapflights users for Portland-Gulfport Biloxi Regional flights.
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From Portland to Biloxi
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Portland to Biloxi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 22, 2026.
Use the filters below to find and compare flights from Portland to Biloxi that are best for you.

Fly from

Portland

Fly to

Biloxi

Route

Depart

Return

Price

PortlandGulfport

PWM - GPT

PWMGPT

Portland

Mon 2/2

2:35 pm-9:53 pm

2 stops8h 18m

Gulfport Biloxi Regional

Sun 2/8

4:00 pm-10:27 pm

1 stop5h 27m

$459

PortlandGulfport

PWM - GPT

PWMGPT

Portland

Mon 2/2

7:00 am-1:19 pm

1 stop7h 19m

Gulfport Biloxi Regional

Sun 2/8

1:45 pm-10:07 pm

1 stop7h 22m

$472

PortlandGulfport

PWM - GPT

PWMGPT

Portland

Sat 4/11

11:56 am-11:58 pm

1 stop13h 02m

Gulfport Biloxi Regional

Mon 4/13

6:10 pm-12:38 pm

1 stop17h 28m

$690

PortlandGulfport

PWM - GPT

PWMGPT

Portland

Thu 2/5

6:00 am-3:58 pm

2 stops10h 58m

Gulfport Biloxi Regional

Mon 2/9

5:13 pm-2:39 pm

2 stops20h 26m

$768

PortlandGulfport

PWM - GPT

PWMGPT

Portland

Sat 4/11

6:04 am-7:53 pm

3 stops14h 49m

Gulfport Biloxi Regional

Mon 4/13

7:05 am-9:40 pm

2 stops13h 35m

$1,072

PortlandGulfport

PWM - GPT

PWMGPT

Portland

Mon 2/2

8:40 am-7:48 pm

2 stops12h 08m

Gulfport Biloxi Regional

Sun 2/8

7:00 am-6:52 pm

3 stops10h 52m

$1,122

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/21

Best time to book a flight from Portland to Biloxi

Have a flexible travel schedule? Discover the best time to fly to Biloxi from Portland with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Portland to Biloxi

What is the cheapest month to book a flight from Portland, Maine to Biloxi?

Currently, March is the cheapest month in which you can book a flight from Portland, Maine to Biloxi (average of $64). Flying from Portland, Maine to Biloxi in December is currently the most expensive (average of $138). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Portland to Biloxi. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Portland to Biloxi?

    If you book a flight to Biloxi from Portland, you will be flying from Portland, which is the city’s only airport. Portland (PWM) is located 2.9 mi from the center of Portland. There are 0 flights from Portland to Biloxi per day from 5 different airlines.

  • How long is the flight from Portland, Maine to Biloxi?

    There are many flights that can get you from Portland, Maine to Biloxi in 7h 19m. Fly via Delta or American Airlines to get the fastest option. The distance from Portland, Maine to Biloxi is about 1374 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Portland to Biloxi that include hotel bookings?

    Yes. In addition to deals on Portland to Biloxi flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Portland to Biloxi?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Portland to Biloxi.

  • Can I find deals for business class flights from Portland to Biloxi?

    Yes. Cheapflights offers flight deals from Portland to Biloxi by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Portland, Maine to Biloxi?

    Currently, March is the cheapest month in which you can book a flight from Portland, Maine to Biloxi (average of $64). Flying from Portland, Maine to Biloxi in December is currently the most expensive (average of $138). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 5 airlines flying from Portland to Biloxi

Discover the top 5 airlines that operate flights from Portland to Biloxi. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 22, 2026.
AirlineCheapestAverageFlexibilityOn-time
JetBlueCheapest$87Average$131FlexibilityNo cancel feeOn-time62%
DeltaCheapest$182Average$368FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$246Average$441FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$271Average$397FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$290Average$476FlexibilityNo cancel feeOn-time63%

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