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$307+ Cheap flights from Mexico City (MEX) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/15. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — SCL
May 28 — Jun 41
Thu 5/28
Thu 6/4
1 adult, Economy
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Find cheap flights from Mexico City to Santiago with Cheapflights

1. Tell us where you want to go

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Cheapflights Tip: The best prices from Mexico City Benito Juarez to Santiago Arturo Merino Benitez are usually found in May or November, booked 90 days in advance, depart on a Wednesday or Thursday and return on a Monday

Cheap flight deals from Mexico City to Santiago

Cheapest flights from Mexico City to Santiago
Explore the most affordable flight options available from Mexico City to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 28, 2026.

This Kiwi.com deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/810:00 pm
MEX
-
SCL
1 stop27h 56m
Multiple Airlines
Mon 6/154:56 am
SCL
-
MEX
1 stop32h 14m
Multiple Airlines
Deal found 4/24$627
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/32:10 am
MEX
-
SCL
2 stops24h 01m
Multiple Airlines
Sun 6/148:20 pm
SCL
-
MEX
1 stop16h 50m
Multiple Airlines
Deal found 4/26$638
This Kiwi.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/49:50 am
MEX
-
SCL
1 stop11h 36m
Copa Airlines
Wed 5/64:09 am
SCL
-
MEX
1 stop12h 21m
Copa Airlines
Deal found 4/23$650
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/155:50 am
MEX
-
SCL
1 stop11h 33m
Copa Airlines
Sat 5/234:41 am
SCL
-
MEX
1 stop11h 49m
Copa Airlines
Deal found 4/27$651
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/171:10 pm
MEX
-
SCL
2 stops37h 01m
Multiple Airlines
Sat 6/278:31 am
SCL
-
MEX
1 stop28h 39m
Multiple Airlines
Deal found 4/26$661
This Kiwi.com deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/101:20 am
MEX
-
SCL
1 stop19h 23m
Copa Airlines
Thu 5/144:09 am
SCL
-
MEX
1 stop12h 21m
Copa Airlines
Deal found 4/24$663
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/263:30 pm
MEX
-
SCL
1 stop25h 53m
Copa Airlines
Tue 6/211:17 am
SCL
-
MEX
1 stop15h 43m
Copa Airlines
Deal found 4/28$664
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/23:30 pm
MEX
-
SCL
1 stop11h 33m
Multiple Airlines
Sun 6/148:20 pm
SCL
-
MEX
1 stop16h 50m
Multiple Airlines
Deal found 4/26$666
This Copa Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/22:10 am
MEX
-
SCL
1 stop19h 16m
Copa Airlines
Tue 5/124:41 am
SCL
-
MEX
1 stop19h 24m
Copa Airlines
Deal found 4/27$682

Find flight deals from Mexico City to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Mexico City (MEX) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 28, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$627
(Kiwi.com)

One-way from

$307
(Kiwi.com)

Popular in

April

Cheapest in

May

Average price

$684

Good round-trip deal

$760 or less

Good one-way deal

$391 or less
Provider with most accurate pricing for Mexico City Benito Juarez-Santiago Arturo Merino Benitez flight deals.
Search Deals
Provider most trusted by Cheapflights users for Mexico City Benito Juarez-Santiago Arturo Merino Benitez flights.
Search Deals
From Mexico City Benito Juarez to Santiago Arturo Merino Benitez
Search Deals
One-way flight from Mexico City Benito Juarez to Santiago Arturo Merino Benitez
Search Deals
Highest demand for flights based on searches. 0% potential increase in price ($1 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 0% potential price decrease ($6 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals
Price to beat on a round-trip flight from Mexico City Benito Juarez to Santiago Arturo Merino Benitez.
Search Deals
Price to beat on a one-way flight from Mexico City Benito Juarez to Santiago Arturo Merino Benitez.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mexico City to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 28, 2026.
Use the filters below to find and compare flights from Mexico City to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Mon 5/4

9:50 am-11:26 pm

1 stop11h 36m

Santiago Arturo Merino Benitez

Wed 5/6

4:09 am-2:30 pm

1 stop12h 21m

$650

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sat 5/2

12:25 am-10:43 pm

1 stop20h 18m

Santiago Arturo Merino Benitez

Fri 5/22

11:17 am-12:15 am

1 stop14h 58m

$682

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Tue 5/26

1:20 am-7:23 pm

1 stop16h 03m

Santiago Arturo Merino Benitez

Sun 5/31

11:17 am-10:05 pm

1 stop12h 48m

$682

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Mon 5/4

5:50 am-3:00 am

1 stop19h 10m

Santiago Arturo Merino Benitez

Sun 8/2

2:27 am-10:05 pm

1 stop21h 38m

$713

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Fri 7/17

9:50 am-3:00 am

1 stop15h 10m

Santiago Arturo Merino Benitez

Sun 7/26

11:22 am-1:00 am

1 stop15h 38m

$744
Cheapest one-way

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Fri 5/29

1:20 am-7:23 pm

1 stop16h 03m

$340

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 5/6

1:20 am-10:43 pm

1 stop19h 23m

$340

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sun 5/10

2:10 am-7:23 pm

1 stop15h 13m

$340

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Fri 5/15

2:10 am-7:23 pm

1 stop15h 13m

$340
Quickest one-way

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Fri 5/29

5:50 am-10:43 pm

1 stop14h 53m

$340

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/24

Showing 1-10 of 16 resultsSorted by cheapest first
1
2

Compare providers for flights from Mexico City to Santiago

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Mexico City to Santiago in April.
ProviderPrice AccuracyTrust Score*
FlightHubPrice Accuracy3 starsTrust Score*3 stars
CheapflightsfaresPrice Accuracy2 starsTrust Score*1 star
GotogatePrice Accuracy2 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Mexico City-Santiago flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Mexico City-Santiago flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Mexico City-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Mexico City-Santiago flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Mexico City-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Mexico City to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Mexico City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Santiago

How far ahead should I book a flight from Mexico City to Santiago?

The best time to book flights from Mexico City to Santiago is 89 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Mexico City to Santiago?

Currently, May is the cheapest month in which you can book a flight from Mexico City to Santiago (average of $555). Flying from Mexico City to Santiago in April is currently the most expensive (average of $684). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MEX to SCL?

Find hourly flight availability from Mexico City to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 28, 2026.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Mexico City to Santiago as you normally would.

How much does it cost to fly round-trip from Mexico City to Santiago?

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated April 28, 2026.
See what other customers who have flown with Copa Airlines,LATAM Airlines, andAeromexico from Mexico City to Santiago have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.5
Good
1,580 reviews

Overall

7.5

Boarding

7.8

Food

6.8

Comfort

7.4

Crew

8.1

Entertainment

6.8

Reviews

1 / 20
2.0
Mediocre

Juan,Dec 2025

EZE - PTY

The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.
Copa Airlines
7.5
Good
1,580 reviews
Copa Airlines
7.5
Good
1,580 reviews

Overall

7.5

Boarding

7.8

Food

6.8

Comfort

7.4

Crew

8.1

Entertainment

6.8

Reviews

1 / 20
2.0
Mediocre

Juan,Dec 2025

EZE - PTY

The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.
LATAM Airlines
7.4
Good
1,913 reviews
Copa Airlines
7.5
Good
1,580 reviews

Overall

7.5

Boarding

7.8

Food

6.8

Comfort

7.4

Crew

8.1

Entertainment

6.8

Reviews

1 / 20
2.0
Mediocre

Juan,Dec 2025

EZE - PTY

The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.
Aeromexico
7.4
Good
1,521 reviews
Copa Airlines
7.5
Good
1,580 reviews

Overall

7.5

Boarding

7.8

Food

6.8

Comfort

7.4

Crew

8.1

Entertainment

6.8

Reviews

1 / 20
2.0
Mediocre

Juan,Dec 2025

EZE - PTY

The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.

Related info for your journey

Find useful and relevant information for your journey from Mexico City to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Mexico City to Santiago flight route?

    Within the past month, 2 users have taken a look at flights from Mexico City Benito Juarez to Santiago Arturo Merino Benitez.

  • How long is the flight from Mexico City to Santiago?

    For as low as $650, Copa Airlines can have you in Santiago from Mexico City in 11h 36m. The distance between Mexico City and Santiago is about 4096 mi.

  • What are the cheapest airlines flying from Mexico City to Santiago round-trip?

    Cheapflights users have booked flights from Mexico City to Santiago round-trip from $284. Other airlines that can offer you cheap pricing are LATAM Airlines, from $329, and Copa Airlines, from $423. Users have found that Aeromexico is 54% cheaper than the other options available to this destination.

  • What are the cheapest airlines to fly from Mexico City to Santiago one-way?

    To fly one-way, consider booking your trip with Aeromexico, which is currently one of the cheapest options available, starting at $76. Avianca flights start at $247 while deals on LATAM Airlines start at $283 one-way.

  • What are the most reliable airlines from Mexico City to Santiago?

    Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Mexico City to Santiago on time: LATAM Airlines (100%), Wamos Air (100%), WestJet (77%).

  • What are the cheapest flights from Mexico City to Santiago?

    While on average a flight from Mexico City to Santiago is generally $606, our data shows the cheapest flight currently is $312. When looking at the most popular route, (Mexico City Benito Juarez - Santiago Arturo Merino Benitez), you can expect to pay $665 for that flight.

  • Can I find deals for flights from Mexico City to Santiago that include hotel bookings?

    Yes. In addition to deals on Mexico City to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mexico City to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Santiago.

  • Can I find deals for business class flights from Mexico City to Santiago?

    Yes. Cheapflights offers flight deals from Mexico City to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mexico City to Santiago?

    Currently, May is the cheapest month in which you can book a flight from Mexico City to Santiago (average of $555). Flying from Mexico City to Santiago in April is currently the most expensive (average of $684). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Complete your trip

Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Santiago car rentals
Santiago Arturo Merino Benitez Airport car rentals
Lastarria car rentals

Top 3 airlines flying from Mexico City to Santiago

Discover the top 3 airlines that operate flights from Mexico City to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 28, 2026.
AirlineCheapestAverageFlexibilityOn-time
AeromexicoCheapest$284Average$608FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$329Average$679FlexibilityNo cancel feeOn-time81%
Copa AirlinesCheapest$423Average$646FlexibilityNo cancel feeOn-time70%

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