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$86+ Cheap flights from Syracuse to St. Louis (SYR - STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/9. Fares are subject to change and may not be available on all flights or dates of travel.
SYR — STL
Apr 10 — Apr 171
Fri 4/10
Fri 4/17
1 adult, Economy
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Cheap flight deals from Syracuse to St. Louis

Cheapest flights from Syracuse to St. Louis
Explore the most affordable flight options available from Syracuse to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 11, 2026.

This American Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/158:21 am
SYR
-
STL
1 stop4h 48m
American Airlines
Tue 8/186:06 am
STL
-
SYR
1 stop4h 34m
American Airlines
Deal found 3/5$271
This United Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/22:21 pm
SYR
-
STL
1 stop6h 30m
United Airlines
Tue 5/56:30 am
STL
-
SYR
2 stops6h 44m
United Airlines
Deal found 3/7$276
This Delta deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/286:00 am
SYR
-
STL
1 stop7h 23m
Delta
Tue 6/26:04 pm
STL
-
SYR
1 stop4h 10m
Delta
Deal found 3/8$280
This American Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/12:04 pm
SYR
-
STL
1 stop5h 00m
American Airlines
Mon 5/42:12 pm
STL
-
SYR
1 stop7h 52m
American Airlines
Deal found 3/7$289
This United Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/66:15 am
SYR
-
STL
1 stop6h 52m
United Airlines
Sat 6/131:13 pm
STL
-
SYR
1 stop7h 06m
United Airlines
Deal found 3/10$291
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/245:15 am
SYR
-
STL
1 stop4h 36m
American Airlines
Sat 3/286:33 pm
STL
-
SYR
1 stop4h 11m
American Airlines
Deal found 3/9$299
This American Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/157:26 pm
SYR
-
STL
1 stop5h 30m
American Airlines
Tue 5/195:51 am
STL
-
SYR
1 stop4h 09m
American Airlines
Deal found 3/10$300
This Delta deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/15:50 am
SYR
-
STL
1 stop4h 56m
Delta
Tue 4/75:15 pm
STL
-
SYR
1 stop4h 23m
Delta
Deal found 3/10$309
This American Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/255:15 am
SYR
-
STL
1 stop4h 36m
American Airlines
Sun 3/296:57 pm
STL
-
SYR
1 stop4h 40m
American Airlines
Deal found 3/10$319
This United Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/236:30 am
SYR
-
STL
1 stop5h 15m
United Airlines
Sat 5/21:24 pm
STL
-
SYR
2 stops9h 06m
United Airlines
Deal found 3/6$320
This United Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/26:30 am
SYR
-
STL
1 stop5h 15m
United Airlines
Tue 4/79:10 am
STL
-
SYR
2 stops10h 10m
United Airlines
Deal found 3/8$325
This Delta deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/86:00 am
SYR
-
STL
1 stop4h 30m
Delta
Mon 7/139:00 am
STL
-
SYR
1 stop6h 21m
Delta
Deal found 3/9$334

Find flight deals from Syracuse to St. Louis

Discover tips and strategies to find the most affordable flight options for your journey from Syracuse (SYR) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 11, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$271
(American Airlines)

One-way from

$86
(Expedia)

Popular in

April

Cheapest in

January

Average price

$378
Provider with most accurate pricing for Syracuse Hancock Intl-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Syracuse Hancock Intl-Lambert-St Louis flights.
Search Deals
From Syracuse Hancock Intl to Lambert-St Louis
Search Deals
One-way flight from Syracuse Hancock Intl to Lambert-St Louis
Search Deals
Highest demand for flights based on searches. 7% potential increase in price ($27 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($7 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Syracuse to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 11, 2026.
Use the filters below to find and compare flights from Syracuse to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

SyracuseSt. Louis

SYR - STL

SYRSTL

Syracuse Hancock Intl

Thu 5/28

6:00 am-12:23 pm

1 stop7h 23m

Lambert-St Louis

Tue 6/2

6:04 pm-11:14 pm

1 stop4h 10m

$280

SyracuseSt. Louis

SYR - STL

SYRSTL

Syracuse Hancock Intl

Thu 4/23

6:30 am-10:45 am

1 stop5h 15m

Lambert-St Louis

Sat 5/2

1:24 pm-11:30 pm

2 stops9h 06m

$320

SyracuseSt. Louis

SYR - STL

SYRSTL

Syracuse Hancock Intl

Fri 6/5

6:15 am-12:11 pm

1 stop6h 56m

Lambert-St Louis

Sun 6/7

1:13 pm-9:19 pm

1 stop7h 06m

$343

SyracuseSt. Louis

SYR - STL

SYRSTL

Syracuse Hancock Intl

Sat 4/4

6:15 am-10:56 am

1 stop5h 41m

Lambert-St Louis

Tue 4/7

7:45 am-6:53 pm

2 stops10h 08m

$355

SyracuseSt. Louis

SYR - STL

SYRSTL

Syracuse Hancock Intl

Fri 6/26

6:15 am-12:11 pm

1 stop6h 56m

Lambert-St Louis

Sun 6/28

1:13 pm-9:19 pm

1 stop7h 06m

$359

SyracuseSt. Louis

SYR - STL

SYRSTL

Syracuse Hancock Intl

Thu 6/4

6:15 am-12:11 pm

1 stop6h 56m

Lambert-St Louis

Mon 6/8

1:13 pm-9:19 pm

1 stop7h 06m

$359

SyracuseSt. Louis

SYR - STL

SYRSTL

Syracuse Hancock Intl

Sat 4/11

6:15 am-9:13 pm

2 stops15h 58m

Lambert-St Louis

Wed 4/15

7:45 am-8:20 pm

2 stops11h 35m

$476
Quickest round-trip

SyracuseSt. Louis

SYR - STL

SYRSTL

Syracuse Hancock Intl

Sun 3/29

5:50 am-9:46 am

1 stop4h 56m

Lambert-St Louis

Sun 4/5

5:59 pm-11:09 pm

1 stop4h 10m

$489
Cheapest one-way

SyracuseSt. Louis

SYR - STL

SYRSTL

Syracuse Hancock Intl

Thu 4/9

8:25 pm-7:51 am

1 stop12h 26m

$86

SyracuseSt. Louis

SYR - STL

SYRSTL

Syracuse Hancock Intl

Thu 8/6

8:16 pm-6:36 pm

2 stops23h 20m

$214

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/8

Showing 1-10 of 17 resultsSorted by cheapest first
1
2

Compare providers for flights from Syracuse to St. Louis

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Syracuse to St. Louis in March.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
JustAirTicketPrice Accuracy-Trust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Syracuse-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Syracuse-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Syracuse-St. Louis flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Syracuse-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Syracuse-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Syracuse to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Syracuse with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Syracuse to St. Louis

How far ahead should I book a flight from Syracuse to St. Louis?

Use this chart to determine the optimal time to book a round-trip flight from Syracuse to St. Louis. Price data was last updated on March 6, 2026.

To ensure you get the cheapest price possible for a flight from Syracuse to St. Louis, you should look to book at least 24 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Syracuse to St. Louis?

Currently, December is the cheapest month in which you can book a flight from Syracuse to St. Louis (average of $184). Flying from Syracuse to St. Louis in March is currently the most expensive (average of $291). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated March 11, 2026.
Read reviews from past customers who have flown Delta,United Airlines, andAmerican Airlines from Syracuse to St. Louis. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,278 reviews

Crew

8.5

Boarding

8.1

Entertainment

7.8

Food

7.2

Comfort

7.9

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
Delta
7.9
Good
8,278 reviews
Delta
7.9
Good
8,278 reviews

Crew

8.5

Boarding

8.1

Entertainment

7.8

Food

7.2

Comfort

7.9

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
United Airlines
7.4
Good
9,414 reviews
Delta
7.9
Good
8,278 reviews

Crew

8.5

Boarding

8.1

Entertainment

7.8

Food

7.2

Comfort

7.9

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
American Airlines
7.1
Good
11,419 reviews
Delta
7.9
Good
8,278 reviews

Crew

8.5

Boarding

8.1

Entertainment

7.8

Food

7.2

Comfort

7.9

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.

Related info for your journey

Find useful and relevant information for your journey from Syracuse to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Syracuse to St. Louis?

    Airlines like Delta and United Airlines fly from Syracuse to St. Louis in about 5h 15m. The time it takes to get you to your destination can typically vary by up to 2h 08m. Airlines will cover a distance of 801 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Syracuse to St. Louis round-trip?

    According to our current data, American Airlines ($248), United Airlines ($248), and Delta ($248) offers the cheapest pricing from Syracuse to St. Louis. American Airlines is 27% cheaper than the average price of flights available within the next 90 days to this destination.

  • What are the cheapest airlines to fly from Syracuse to St. Louis one-way?

    $118 is the cheapest one-way deal found within the past few days, from Delta. You may also be able to find cheap deals on American Airlines and United Airlines, with prices starting from $175 and $238, respectively.

  • Can I find deals for flights from Syracuse to St. Louis that include hotel bookings?

    Yes. In addition to deals on Syracuse to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Syracuse to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Syracuse to St. Louis.

  • Can I find deals for business class flights from Syracuse to St. Louis?

    Yes. Cheapflights offers flight deals from Syracuse to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Syracuse to St. Louis?

    Currently, December is the cheapest month in which you can book a flight from Syracuse to St. Louis (average of $184). Flying from Syracuse to St. Louis in March is currently the most expensive (average of $291). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
Edwardsville
O'Fallon
Fenton
Swansea
Fairview Heights
Maryland Heights
Collinsville
Eureka
Wentzville
Glencoe
Chesterfield
Alton
Farmington
Festus

Browse thousands of different options on Cheapflights for your next trip

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Top 3 airlines flying from Syracuse to St. Louis

Discover the top 3 airlines that operate flights from Syracuse to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 11, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$248Average$343FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$248Average$346FlexibilityNo cancel feeOn-time71%
DeltaCheapest$248Average$336FlexibilityNo cancel feeOn-timeN/A

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