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St. Louis

$87+ Cheap flights from Syracuse to St. Louis (SYR - STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/30. Fares are subject to change and may not be available on all flights or dates of travel.
SYR — STL
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheapflights Tip: The best prices from Syracuse Hancock Intl to Lambert-St Louis are usually found in February or May, booked 81 days in advance, depart on a Friday or Saturday and return on a Tuesday

Cheap flight deals from Syracuse to St. Louis

Discover tips and strategies to find the most affordable flight options for your journey from Syracuse (SYR) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$248
(American Airlines)

One-way from

$87
(Kiwi.com)

Popular in

December

Cheapest in

February

Average price

$362
From Syracuse Hancock Intl to Lambert-St Louis
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One-way flight from Syracuse Hancock Intl to Lambert-St Louis
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Highest demand for flights based on searches. 8% potential increase in price ($32 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($11 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Syracuse to St. Louis

Cheapest flights from Syracuse to St. Louis
Explore the most affordable flight options available from Syracuse to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2512:29 pmSYR - STL
1 stop7h 13mAmerican Airlines
Sat 11/19:58 amSTL - SYR
1 stop5h 17mAmerican Airlines
Deal found 9/10$248
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/25:28 pmSYR - STL
1 stop7h 25mAmerican Airlines
Sun 10/54:58 pmSTL - SYR
1 stop4h 56mAmerican Airlines
Deal found 9/10$249
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/266:44 pmSYR - STL
1 stop5h 40mDelta
Sun 9/286:01 amSTL - SYR
1 stop4h 19mDelta
Deal found 9/9$259
This Delta deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/306:59 pmSYR - STL
1 stop5h 40mDelta
Sun 1/43:35 pmSTL - SYR
1 stop7h 06mDelta
Deal found 9/11$263
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/256:00 amSYR - STL
2 stops9h 27mUnited Airlines
Wed 10/2910:00 amSTL - SYR
1 stop5h 40mUnited Airlines
Deal found 9/10$273
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/67:56 pmSYR - STL
1 stop5h 00mAmerican Airlines
Sun 11/96:45 pmSTL - SYR
1 stop4h 34mAmerican Airlines
Deal found 9/10$274
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/256:01 pmSYR - STL
2 stops40h 31mMultiple Airlines
Sat 11/17:15 pmSTL - SYR
1 stop23h 30mMultiple Airlines
Deal found 9/10$288
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/253:14 pmSYR - STL
2 stops7h 52mAmerican Airlines
Wed 10/296:25 amSTL - SYR
1 stop6h 38mAmerican Airlines
Deal found 9/10$305
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/196:47 pmSYR - STL
1 stop5h 20mAmerican Airlines
Sun 9/215:27 amSTL - SYR
1 stop4h 33mAmerican Airlines
Deal found 9/10$309
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/116:15 amSYR - STL
1 stop5h 34mUnited Airlines
Mon 10/136:30 amSTL - SYR
1 stop4h 28mUnited Airlines
Deal found 9/10$319
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2412:39 pmSYR - STL
1 stop6h 38mUnited Airlines
Wed 10/2912:31 pmSTL - SYR
2 stops9h 42mUnited Airlines
Deal found 9/10$323
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/26:00 amSYR - STL
2 stops10h 44mUnited Airlines
Sun 10/55:00 amSTL - SYR
1 stop5h 58mUnited Airlines
Deal found 9/10$324

Cheapflights Fare Finder

 
Customize your flight search to find flights from Syracuse to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Syracuse to St. Louis that are best for you.

Fly from

Syracuse

Fly to

St. Louis

Route

Depart

Return

Price

SyracuseSt. Louis

SYR - STL

SYRSTL

Syracuse Hancock Intl

Sat 10/25

12:29 pm-6:42 pm

1 stop7h 13m

Lambert-St Louis

Sat 11/1

9:58 am-4:15 pm

1 stop5h 17m

$248

SyracuseSt. Louis

SYR - STL

SYRSTL

Syracuse Hancock Intl

Sat 10/11

5:43 pm-9:37 pm

1 stop4h 54m

Lambert-St Louis

Tue 10/14

9:20 am-4:47 pm

1 stop6h 27m

$249

SyracuseSt. Louis

SYR - STL

SYRSTL

Syracuse Hancock Intl

Tue 12/30

6:59 pm-11:39 pm

1 stop5h 40m

Lambert-St Louis

Sun 1/4

3:35 pm-11:41 pm

1 stop7h 06m

$249

SyracuseSt. Louis

SYR - STL

SYRSTL

Syracuse Hancock Intl

Thu 10/2

5:28 pm-11:53 pm

1 stop7h 25m

Lambert-St Louis

Sun 10/5

4:58 pm-10:54 pm

1 stop4h 56m

$249

SyracuseSt. Louis

SYR - STL

SYRSTL

Syracuse Hancock Intl

Tue 11/25

10:31 am-3:46 pm

1 stop6h 15m

Lambert-St Louis

Sun 11/30

3:14 pm-8:41 pm

1 stop4h 27m

$249

SyracuseSt. Louis

SYR - STL

SYRSTL

Syracuse Hancock Intl

Fri 10/10

12:39 pm-6:17 pm

1 stop6h 38m

Lambert-St Louis

Tue 10/14

9:20 am-4:47 pm

1 stop6h 27m

$249

SyracuseSt. Louis

SYR - STL

SYRSTL

Syracuse Hancock Intl

Thu 9/25

6:00 am-9:33 am

1 stop4h 33m

Lambert-St Louis

Sat 9/27

3:55 pm-11:59 pm

1 stop7h 04m

$259

SyracuseSt. Louis

SYR - STL

SYRSTL

Syracuse Hancock Intl

Fri 9/26

6:44 pm-11:24 pm

1 stop5h 40m

Lambert-St Louis

Sun 9/28

6:01 am-11:20 am

1 stop4h 19m

$259

SyracuseSt. Louis

SYR - STL

SYRSTL

Syracuse Hancock Intl

Sun 12/21

6:00 am-9:24 am

1 stop4h 24m

Lambert-St Louis

Sat 12/27

5:55 pm-11:15 pm

1 stop4h 20m

$263

SyracuseSt. Louis

SYR - STL

SYRSTL

Syracuse Hancock Intl

Sat 10/25

6:01 pm-9:32 am

2 stops40h 31m

Lambert-St Louis

Sat 11/1

7:15 pm-7:45 pm

1 stop23h 30m

$288

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/8

Showing 1-10 of 20 results
1
2

Best time to book a flight from Syracuse to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Syracuse with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Syracuse to St. Louis

How far ahead should I book a flight from Syracuse to St. Louis?

Use this chart to determine the optimal time to book a round-trip flight from Syracuse to St. Louis. Price data was last updated on August 29, 2025.

To ensure you get the cheapest price possible for a flight from Syracuse to St. Louis, you should look to book at least 24 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Syracuse to St. Louis?

Currently, August is the cheapest month in which you can book a flight from Syracuse to St. Louis (average of $311). Flying from Syracuse to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SYR to STL?

Find hourly flight availability from Syracuse to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 11, 2025.

Unlike in the afternoon, when flights are generally more expensive, you can save up to 32% on flights from Syracuse to St. Louis by exploring options for tickets in the evening.

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated September 11, 2025.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Syracuse to St. Louis. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,960 reviews

Crew

8.5

Boarding

8.2

Entertainment

7.9

Overall

8.0

Food

7.3

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
Delta
8.0
Very good
7,960 reviews
Delta
8.0
Very good
7,960 reviews

Crew

8.5

Boarding

8.2

Entertainment

7.9

Overall

8.0

Food

7.3

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
United Airlines
7.4
Good
8,937 reviews
Delta
8.0
Very good
7,960 reviews

Crew

8.5

Boarding

8.2

Entertainment

7.9

Overall

8.0

Food

7.3

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,960 reviews

Crew

8.5

Boarding

8.2

Entertainment

7.9

Overall

8.0

Food

7.3

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.

Related info for your journey

Find useful and relevant information for your journey from Syracuse to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Syracuse to St. Louis?

    Airlines like American Airlines, United Airlines, and Delta fly from Syracuse to St. Louis in about 4h 54m. The time it takes to get you to your destination can typically vary by up to 2h 19m. Airlines will cover a distance of 801 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Syracuse to St. Louis round-trip?

    According to our current data, American Airlines ($248), Delta ($248), and United Airlines ($306) offers the cheapest pricing from Syracuse to St. Louis. American Airlines is 34% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Syracuse to St. Louis that include hotel bookings?

    Yes. In addition to deals on Syracuse to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Syracuse to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Syracuse to St. Louis.

  • Can I find deals for business class flights from Syracuse to St. Louis?

    Yes. Cheapflights offers flight deals from Syracuse to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Syracuse to St. Louis?

    Currently, August is the cheapest month in which you can book a flight from Syracuse to St. Louis (average of $311). Flying from Syracuse to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
Edwardsville
O'Fallon
Fairview Heights
Maryland Heights
Collinsville
Eureka
Glencoe
St. Peters
Chesterfield
Alton
Farmington
Festus

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Alternative routes for Syracuse to St. Louis

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Syracuse to St. Louis

Discover the top 3 airlines that operate flights from Syracuse to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$248Average$370FlexibilityNo cancel feeOn-time71%
DeltaCheapest$248Average$353FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$306Average$541FlexibilityNo cancel feeOn-time69%

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