What are the cheapest airlines flying from Detroit Metropolitan Wayne County Airport to St. Louis round-trip?

Our cheapest airline available from Detroit Metropolitan Wayne County Airport to St. Louis is Spirit Airlines. Our recent data shows that you can find tickets from as low as $36 on this airline. Additional options worth looking into are Frontier and Southwest, starting at $111 and $137 round-trip. You may be able to fly from Detroit Metropolitan Wayne County Airport to St. Louis for 86% less than the average price by searching for these airlines.

Weekly flight availability from Detroit Metropolitan Wayne County Airport to St. Louis

The most flights from DTW to STL are scheduled on a Monday (17 on average). You will have fewer flight options on Saturday, which is when the least amount of flights are scheduled (3 on average).

In terms of precipitation, rainfall in St. Louis ranges from 2.2 - 4.7 inches per month. May is typically the wettest month, when rainfall can reach 4.7 in. February is typically the driest time to visit St. Louis when rainfall is around 2.2 in.

If weather is an important factor for your trip to St. Louis, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 32.0 F).

What are the cheapest flights from Detroit Metropolitan Wayne County Airport to St. Louis?

On average you can expect to pay $300 for a flight from Detroit Metropolitan Wayne County Airport to St. Louis. The cheapest flight overall is $127 while the most popular route, (Detroit Metropolitan Wayne County - Lambert-St Louis) is currently priced at $181.

What are the most reliable airlines from Detroit Metropolitan Wayne County Airport to St. Louis?

No one likes to see their flight delayed. When booking a flight from Detroit Metropolitan Wayne County Airport to St. Louis consider choosing SkyWest Airlines (100%), Endeavor Airlines (100%) or Delta (95%) as they are the most reliable in getting you off to your destination on time.

What are the most popular airlines that fly from Detroit Metropolitan Wayne County Airport to St. Louis?

Before booking your flight from Detroit Metropolitan Wayne County Airport to St. Louis check out the most popular airlines for this route: Delta, Southwest or Spirit Airlines.

Most accurate provider : When it comes to deals on Detroit Metropolitan Wayne County Airport-St. Louis flights, users find the pricing of Justfly.com to be most consistent on Cheapflights vs. Justfly.com Users can find the same prices on Detroit Metropolitan Wayne County Airport-St. Louis flight deals on Cheapflights vs. Justfly.com >95% of the time. Price accuracy is based on data collected from Detroit Metropolitan Wayne County Airport-St. Louis flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Detroit Metropolitan Wayne County Airport-St. Louis flights, Cheapflights users trust Justfly.com the most. Justfly.com has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Detroit Metropolitan Wayne County Airport-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

What airports do I use to fly from Detroit to St. Louis?

If you book a flight from Detroit to St. Louis, you will be flying from Detroit Metropolitan Wayne County to Lambert-St Louis. Flights to Lambert-St Louis (STL) from Detroit Metropolitan Wayne County (DTW) take 1h 40m for a nonstop flight. There are 13 flights from Detroit Metropolitan Wayne County to St. Louis per day from 4 airlines.

Can I find deals for flights from Detroit to St. Louis that include hotel bookings?

Yes. In addition to deals on Detroit to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Detroit to St. Louis?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Detroit to St. Louis.

Can I find deals for business class flights from Detroit to St. Louis?

Yes. Cheapflights offers flight deals from Detroit to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$55+ Flights from Detroit Metropolitan Wayne County Airport to St. Louis

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1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

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Cheapflights Tip: The best prices from Detroit Metropolitan Wayne County to Lambert-St Louis are usually found in July or August, booked 54 days in advance, depart on a Friday or Thursday and return on a Friday

Cheap flight deals from Detroit to St. Louis

Most accurate provider	Justfly.com 3 stars
Most trusted provider	Justfly.com 3 stars
Round-trip from	$110 (Priceline)
One-way from	$55 (Frontier)
Popular in	December
Cheapest in	July
Average price	$339
Good round-trip deal	$291 or less
Good one-way deal	$202 or less

Provider with most accurate pricing for Detroit Metropolitan Wayne County-Lambert-St Louis flight deals.

Search Deals

Provider most trusted by Cheapflights users for Detroit Metropolitan Wayne County-Lambert-St Louis flights.

Search Deals

From Detroit Metropolitan Wayne County to Lambert-St Louis

Search Deals

One-way flight from Detroit Metropolitan Wayne County to Lambert-St Louis

Search Deals

Highest demand for flights based on searches. 20% potential increase in price ($70 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 3% potential price decrease ($8 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in November 2025

Search Deals

Price to beat on a round-trip flight from Detroit Metropolitan Wayne County to Lambert-St Louis.

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Price to beat on a one-way flight from Detroit Metropolitan Wayne County to Lambert-St Louis.

Search Deals

Find flight deals from Detroit to St. Louis

Cheapest flights from Detroit to St. Louis
Explore the most affordable flight options available from Detroit to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 12, 2025.

Sat 12/1312:38 pmDTW - STL

1 stop10h 55mFrontier

Mon 12/159:54 amSTL - DTW

1 stop6h 23mFrontier

Deal found 11/11

$110

Mon 12/811:13 amDTW - STL

1 stop12h 20mMultiple Airlines

Thu 12/1112:04 pmSTL - DTW

1 stop6h 48mMultiple Airlines

Deal found 11/10

$177

Mon 11/175:14 pmDTW - STL

1 stop16h 53mFrontier

Tue 11/254:13 pmSTL - DTW

1 stop24h 55mFrontier

Deal found 11/9

$178

Wed 12/36:59 pmDTW - STL

1 stop17h 08mMultiple Airlines

Sun 12/710:42 amSTL - DTW

1 stop20h 25mMultiple Airlines

Deal found 11/9

$181

Mon 11/245:33 amDTW - STL

1 stop10h 39mAmerican Airlines

Thu 11/276:00 amSTL - DTW

1 stop9h 00mAmerican Airlines

Deal found 11/10

$183

Thu 12/45:50 amDTW - STL

1 stop6h 17mMultiple Airlines

Mon 12/83:30 pmSTL - DTW

2 stops15h 37mMultiple Airlines

Deal found 11/10

$189

Mon 12/86:12 pmDTW - STL

2 stops41h 02mMultiple Airlines

Mon 12/1510:47 amSTL - DTW

1 stop8h 05mMultiple Airlines

Deal found 11/10

$192

Sun 12/146:12 pmDTW - STL

1 stop15h 47mFrontier

Sun 1/255:11 pmSTL - DTW

2 stops17h 29mFrontier

Deal found 11/10

$199

Best flights from Detroit to St. Louis
Discover carefully curated flight deals from Detroit to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 12, 2025.

Thu 1/1511:05 amDTW - STL

1 stop4h 25mUnited Airlines

Mon 1/193:11 pmSTL - DTW

1 stop4h 15mUnited Airlines

Deal found 11/12

$191

Thu 12/412:20 pmDTW - STL

1 stop22h 54mFrontier

Mon 12/89:54 amSTL - DTW

1 stop6h 23mFrontier

Deal found 11/10

$201

Tue 12/96:45 pmDTW - STL

Nonstop1h 40mSouthwest

Tue 12/166:10 pmSTL - DTW

Nonstop1h 30mSouthwest

Deal found 11/11

$217

Mon 11/245:20 amDTW - STL

1 stop19h 37mMultiple Airlines

Tue 11/259:54 pmSTL - DTW

1 stop31h 11mMultiple Airlines

Deal found 11/12

$218

Mon 12/222:55 pmDTW - STL

1 stop8h 38mFrontier

Sun 12/2810:57 amSTL - DTW

1 stop6h 12mFrontier

Deal found 11/12

$213

Wed 12/36:00 amDTW - STL

1 stop5h 50mUnited Airlines

Sat 12/66:42 pmSTL - DTW

1 stop3h 49mUnited Airlines

Deal found 11/12

$214

Wed 12/36:45 pmDTW - STL

Nonstop1h 40mSouthwest

Sat 12/61:35 pmSTL - DTW

Nonstop1h 30mSouthwest

Deal found 11/11

$227

Thu 12/46:45 pmDTW - STL

Nonstop1h 40mSouthwest

Mon 12/86:10 pmSTL - DTW

Nonstop1h 30mSouthwest

Deal found 11/10

$237

Thu 12/1812:25 pmDTW - STL

2 stops8h 40mSouthwest

Wed 12/244:25 pmSTL - DTW

1 stop5h 15mSouthwest

Deal found 11/10

$252

Last-minute flights from Detroit to St. Louis
Discover last-minute flight deals from Detroit to St. Louis. Data last updated November 12, 2025 and is based on user searches.

Mon 11/175:14 pmDTW - STL

1 stop16h 53mFrontier

Tue 11/254:13 pmSTL - DTW

1 stop24h 55mFrontier

Deal found 11/9

$178

Mon 11/245:33 amDTW - STL

1 stop10h 39mAmerican Airlines

Thu 11/276:00 amSTL - DTW

1 stop9h 00mAmerican Airlines

Deal found 11/10

$183

Wed 12/36:59 pmDTW - STL

1 stop17h 08mMultiple Airlines

Sun 12/710:42 amSTL - DTW

1 stop20h 25mMultiple Airlines

Deal found 11/9

$181

Thu 12/45:50 amDTW - STL

1 stop6h 17mMultiple Airlines

Mon 12/83:30 pmSTL - DTW

2 stops15h 37mMultiple Airlines

Deal found 11/10

$189

Mon 12/811:13 amDTW - STL

1 stop12h 20mMultiple Airlines

Thu 12/1112:04 pmSTL - DTW

1 stop6h 48mMultiple Airlines

Deal found 11/10

$177

Mon 12/86:12 pmDTW - STL

2 stops41h 02mMultiple Airlines

Mon 12/1510:47 amSTL - DTW

1 stop8h 05mMultiple Airlines

Deal found 11/10

$192

Sat 12/1312:38 pmDTW - STL

1 stop10h 55mFrontier

Mon 12/159:54 amSTL - DTW

1 stop6h 23mFrontier

Deal found 11/11

$110

Sun 12/146:12 pmDTW - STL

1 stop15h 47mFrontier

Sun 1/2510:42 amSTL - DTW

1 stop23h 58mFrontier

Deal found 11/10

$199

One-way flights from Detroit to St. Louis
Search for one-way flight options from Detroit to St. Louis. Find affordable one-way fares based on user searches. Data last updated November 12, 2025.

Sat 1/244:07 pmDTW - STL

1 stop7h 26mFrontier

Deal found 11/11

$55

Sat 12/1312:38 pmDTW - STL

1 stop10h 55mFrontier

Deal found 11/11

$61

Mon 1/1211:28 amDTW - STL

1 stop12h 05mFrontier

Deal found 11/12

$66

Mon 1/196:07 pmDTW - STL

1 stop29h 26mFrontier

Deal found 11/10

$67

Fri 1/94:43 pmDTW - STL

1 stop18h 19mFrontier

Deal found 11/12

$68

Thu 1/110:01 pmDTW - STL

1 stop13h 01mFrontier

Deal found 11/11

$69

Sat 12/208:54 pmDTW - STL

1 stop26h 39mFrontier

Deal found 11/11

$70

Thu 12/187:50 amDTW - STL

1 stop9h 34mFrontier

Deal found 11/10

$72

Thu 1/86:13 pmDTW - STL

1 stop21h 35mFrontier

Deal found 11/12

$77

Wed 12/102:50 pmDTW - STL

1 stop21h 17mMultiple Airlines

Deal found 11/9

$78

Fri 1/2312:05 pmDTW - STL

1 stop22h 57mFrontier

Deal found 11/9

$79

Cheapflights Fare Finder

Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Thu 1/15

11:05 am-2:30 pm

1 stop4h 25m

Lambert-St Louis

Mon 1/19

3:11 pm-8:26 pm

1 stop4h 15m

$191

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Thu 12/4

12:20 pm-10:14 am

1 stop22h 54m

Lambert-St Louis

Mon 12/8

9:54 am-5:17 pm

1 stop6h 23m

$201

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Mon 12/22

2:55 pm-10:33 pm

1 stop8h 38m

Lambert-St Louis

Sun 12/28

10:57 am-6:09 pm

1 stop6h 12m

$213

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Wed 12/3

6:00 am-10:50 am

1 stop5h 50m

Lambert-St Louis

Sat 12/6

6:42 pm-11:31 pm

1 stop3h 49m

$214

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Tue 12/9

6:45 pm-7:25 pm

Nonstop1h 40m

Lambert-St Louis

Tue 12/16

6:10 pm-8:40 pm

Nonstop1h 30m

$217

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Mon 11/24

5:20 am-11:57 pm

1 stop19h 37m

Lambert-St Louis

Tue 11/25

9:54 pm-6:05 am

1 stop31h 11m

$218

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Wed 12/3

6:45 pm-7:25 pm

Nonstop1h 40m

Lambert-St Louis

Sat 12/6

1:35 pm-4:05 pm

Nonstop1h 30m

$227

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Thu 12/4

6:45 pm-7:25 pm

Nonstop1h 40m

Lambert-St Louis

Mon 12/8

6:10 pm-8:40 pm

Nonstop1h 30m

$237

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Thu 12/18

12:25 pm-8:05 pm

2 stops8h 40m

Lambert-St Louis

Wed 12/24

4:25 pm-10:40 pm

1 stop5h 15m

$252

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Wed 2/4

5:15 am-10:33 pm

1 stop18h 18m

$80

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/10

Showing 1-10 of 19 results

Compare providers for flights from Detroit to St. Louis

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Detroit to St. Louis in November.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy2 stars	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*1 star
eDreams	Price Accuracy3 stars	Trust Score*3 stars
Justfly.com	Price Accuracy3 stars	Trust Score*3 stars
Priceline	Price Accuracy1 star	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Detroit Metropolitan Wayne County Airport-St. Louis flights, users find the pricing of Justfly.com to be most consistent on Cheapflights vs. Justfly.com Users can find the same prices on Detroit Metropolitan Wayne County Airport-St. Louis flight deals on Cheapflights vs. Justfly.com >95% of the time. Price accuracy is based on data collected from Detroit Metropolitan Wayne County Airport-St. Louis flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Detroit Metropolitan Wayne County Airport-St. Louis flights, Cheapflights users trust Justfly.com the most. Justfly.com has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Detroit Metropolitan Wayne County Airport-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Detroit to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Detroit with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Detroit Metropolitan Wayne County Airport to St. Louis

Prices

Airlines

How far ahead should I book a flight from Detroit Metropolitan Wayne County Airport to St. Louis?

The price you pay for your flight from Detroit Metropolitan Wayne County Airport to St. Louis may vary depending on when you book. For the best chance of a lower fare, look to book 54 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Detroit Metropolitan Wayne County Airport to St. Louis?

Currently, August is the cheapest month in which you can book a flight from Detroit Metropolitan Wayne County Airport to St. Louis (average of $40). Flying from Detroit Metropolitan Wayne County Airport to St. Louis in December is currently the most expensive (average of $270). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DTW to STL?

Unlike in the morning, when flights are generally more expensive, you can save up to 16% on flights from Detroit Metropolitan Wayne County Airport to St. Louis by exploring options for tickets at noon.

What is the cheapest day to fly from Detroit Metropolitan Wayne County Airport to St. Louis?

Travelers seeking maximum savings on their Detroit Metropolitan Wayne County Airport to St. Louis flight should consider departing on Friday at noon when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

The best insider tips for Detroit Metropolitan Wayne County Airport to St. Louis flights

Cheapflights partnered with top experts to bring you the best recommendations for your Detroit Metropolitan Wayne County Airport to St. Louis trip

Airports

DTW

At DTW, security lines are generally short, with waits rarely exceeding 10 minutes in McNamara Terminal, making it efficient for business travelers.

STL

Use the MetroLink light rail from STL for a convenient, economical ride to downtown St. Louis, taking about 40 minutes.

Our travel experts

Brandon Schultz

Expert on DTW

Taryn White

Expert on STL

Reviews of airlines servicing St. Louis

Read reviews from past customers who have flown Southwest, Delta, and Spirit Airlines from Detroit Metropolitan Wayne County Airport to St. Louis. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Southwest

8.0

Very good

4,235 reviews

Reviews

1 / 20

2.0

Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Southwest

8.0

Very good

4,235 reviews

Southwest

8.0

Very good

4,235 reviews

Reviews

1 / 20

2.0

Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Delta

7.9

Good

8,008 reviews

Southwest

8.0

Very good

4,235 reviews

Reviews

1 / 20

2.0

Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Spirit Airlines

6.3

Okay

8,137 reviews

Southwest

8.0

Very good

4,235 reviews

Reviews

1 / 20

2.0

Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Frontier

5.8

Fair

3,113 reviews

Southwest

8.0

Very good

4,235 reviews

Reviews

1 / 20

2.0

Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

What airports do I use to fly from Detroit to St. Louis?
If you book a flight from Detroit to St. Louis, you will be flying from Detroit Metropolitan Wayne County to Lambert-St Louis. Flights to Lambert-St Louis (STL) from Detroit Metropolitan Wayne County (DTW) take 1h 40m for a nonstop flight. There are 13 flights from Detroit Metropolitan Wayne County to St. Louis per day from 4 airlines.
How long is the flight from Detroit Metropolitan Wayne County Airport to St. Louis?
For as low as $217, United Airlines can have you in St. Louis from Detroit Metropolitan Wayne County Airport in 1h 40m. Airlines will cover a distance of 439 mi. Both multi-stop and nonstop flights can be found to your destination and back.
What are the cheapest airlines flying from Detroit Metropolitan Wayne County Airport to St. Louis round-trip?
Our cheapest airline available from Detroit Metropolitan Wayne County Airport to St. Louis is Spirit Airlines. Our recent data shows that you can find tickets from as low as $36 on this airline. Additional options worth looking into are Frontier and Southwest, starting at $111 and $137 round-trip. You may be able to fly from Detroit Metropolitan Wayne County Airport to St. Louis for 86% less than the average price by searching for these airlines.
What are the most reliable airlines from Detroit Metropolitan Wayne County Airport to St. Louis?
No one likes to see their flight delayed. When booking a flight from Detroit Metropolitan Wayne County Airport to St. Louis consider choosing SkyWest Airlines (100%), Endeavor Airlines (100%) or Delta (95%) as they are the most reliable in getting you off to your destination on time.
What are the cheapest flights from Detroit Metropolitan Wayne County Airport to St. Louis?
On average you can expect to pay $300 for a flight from Detroit Metropolitan Wayne County Airport to St. Louis. The cheapest flight overall is $127 while the most popular route, (Detroit Metropolitan Wayne County - Lambert-St Louis) is currently priced at $181.
Can I find deals for flights from Detroit to St. Louis that include hotel bookings?
Yes. In addition to deals on Detroit to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Detroit to St. Louis?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Detroit to St. Louis.
Can I find deals for business class flights from Detroit to St. Louis?
Yes. Cheapflights offers flight deals from Detroit to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Detroit Metropolitan Wayne County Airport to St. Louis?
Currently, August is the cheapest month in which you can book a flight from Detroit Metropolitan Wayne County Airport to St. Louis (average of $40). Flying from Detroit Metropolitan Wayne County Airport to St. Louis in December is currently the most expensive (average of $270). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Other flights to St. Louis

Top 4 airlines flying from Detroit to St. Louis

Airline	Cheapest	Average	Flexibility	On-time
Spirit Airlines	Cheapest$36	Average$101	FlexibilityNo cancel fee	On-time65%
Frontier	Cheapest$111	Average$262	FlexibilityNo cancel fee	On-time62%
Southwest	Cheapest$137	Average$297	FlexibilityNo cancel fee	On-time63%
Delta	Cheapest$137	Average$303	FlexibilityNo cancel fee	On-timeN/A

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$55+ Cheap flights from Detroit Metropolitan Wayne County Airport to St. Louis (DTW - STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/24. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Detroit to St. Louis with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from Detroit Metropolitan Wayne County to Lambert-St Louis are usually found in July or August, booked 54 days in advance, depart on a Friday or Thursday and return on a Friday

Cheap flight deals from Detroit to St. Louis

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Good round-trip deal

Good one-way deal

Find flight deals from Detroit to St. Louis

Cheapest flights from Detroit to St. LouisExplore the most affordable flight options available from Detroit to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 12, 2025.

Explore the most affordable flight options available from Detroit to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 12, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to St. Louis that are best for you.

Compare providers for flights from Detroit to St. Louis

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Detroit to St. Louis in November.

Best time to book a flight from Detroit to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Detroit with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Detroit Metropolitan Wayne County Airport to St. Louis

How far ahead should I book a flight from Detroit Metropolitan Wayne County Airport to St. Louis?

What is the cheapest month to book a flight from Detroit Metropolitan Wayne County Airport to St. Louis?

What is the cheapest time of day to fly from DTW to STL?

What is the cheapest day to fly from Detroit Metropolitan Wayne County Airport to St. Louis?

Weekly flight availability from Detroit Metropolitan Wayne County Airport to St. Louis

The best insider tips for Detroit Metropolitan Wayne County Airport to St. Louis flights

Cheapflights partnered with top experts to bring you the best recommendations for your Detroit Metropolitan Wayne County Airport to St. Louis trip

Airports

DTW

STL

Our travel experts

Reviews of airlines servicing St. Louis

Related info for your journey

Find useful and relevant information for your journey from Detroit to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airports do I use to fly from Detroit to St. Louis?

How long is the flight from Detroit Metropolitan Wayne County Airport to St. Louis?

What are the cheapest airlines flying from Detroit Metropolitan Wayne County Airport to St. Louis round-trip?

What are the most reliable airlines from Detroit Metropolitan Wayne County Airport to St. Louis?

What are the cheapest flights from Detroit Metropolitan Wayne County Airport to St. Louis?

Can I find deals for flights from Detroit to St. Louis that include hotel bookings?

How can I find direct flights from Detroit to St. Louis?

Can I find deals for business class flights from Detroit to St. Louis?

What is the cheapest month to book a flight from Detroit Metropolitan Wayne County Airport to St. Louis?

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Top 4 airlines flying from Detroit to St. Louis

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Cheapest flights from Detroit to St. Louis
Explore the most affordable flight options available from Detroit to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 12, 2025.