What are the cheapest airlines flying from Detroit Metropolitan Wayne County Airport to St. Louis round-trip?

Our cheapest airline available from Detroit Metropolitan Wayne County Airport to St. Louis is Spirit Airlines. Our recent data shows that you can find tickets from as low as $36 on this airline. Additional options worth looking into are Delta and Southwest, starting at $140 and $148 round-trip. You may be able to fly from Detroit Metropolitan Wayne County Airport to St. Louis for 86% less than the average price by searching for these airlines.

Weekly flight availability from Detroit Metropolitan Wayne County Airport to St. Louis

The most flights from DTW to STL are scheduled on a Monday (16 on average). You will have fewer flight options on Saturday, which is when the least amount of flights are scheduled (2 on average).

In terms of precipitation, rainfall in St. Louis ranges from 2.2 - 4.7 inches per month. May is typically the wettest month, when rainfall can reach 4.7 in. February is typically the driest time to visit St. Louis when rainfall is around 2.2 in.

If weather is an important factor for your trip to St. Louis, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 32.0 F).

What are the cheapest flights from Detroit Metropolitan Wayne County Airport to St. Louis?

On average you can expect to pay $260 for a flight from Detroit Metropolitan Wayne County Airport to St. Louis. The cheapest flight overall is $69 while the most popular route, (Detroit Metropolitan Wayne County - Lambert-St Louis) is currently priced at $165.

What are the most reliable airlines from Detroit Metropolitan Wayne County Airport to St. Louis?

No one likes to see their flight delayed. When booking a flight from Detroit Metropolitan Wayne County Airport to St. Louis consider choosing SkyWest Airlines (100%), KLM (88%) or Southwest (86%) as they are the most reliable in getting you off to your destination on time.

What are the most popular airlines that fly from Detroit Metropolitan Wayne County Airport to St. Louis?

Before booking your flight from Detroit Metropolitan Wayne County Airport to St. Louis check out the most popular airlines for this route: Delta, Spirit Airlines or United Airlines.

Most accurate provider : When it comes to deals on Detroit Metropolitan Wayne County Airport-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Detroit Metropolitan Wayne County Airport-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Detroit Metropolitan Wayne County Airport-St. Louis flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Detroit Metropolitan Wayne County Airport-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Detroit Metropolitan Wayne County Airport-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

What airports do I use to fly from Detroit to St. Louis?

If you book a flight from Detroit to St. Louis, you will be flying from Detroit Metropolitan Wayne County to Lambert-St Louis. Flights to Lambert-St Louis (STL) from Detroit Metropolitan Wayne County (DTW) take 1h 35m for a nonstop flight. There are 11 flights from Detroit Metropolitan Wayne County to St. Louis per day from 4 airlines.

Can I find deals for flights from Detroit to St. Louis that include hotel bookings?

Yes. In addition to deals on Detroit to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Detroit to St. Louis?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Detroit to St. Louis.

Can I find deals for business class flights from Detroit to St. Louis?

Yes. Cheapflights offers flight deals from Detroit to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$74+ Flights from Detroit Metropolitan Wayne County Airport to St. Louis

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1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Detroit Metropolitan Wayne County to Lambert-St Louis are usually found in July or August, booked 54 days in advance, depart on a Friday or Thursday and return on a Friday

Cheap flight deals from Detroit to St. Louis

Most accurate provider	FlightHub 3 stars
Most trusted provider	FlightHub 3 stars
Round-trip from	$154 (Booking.com)
One-way from	$74 (Kiwi.com)
Popular in	October
Cheapest in	July
Average price	$311
Good round-trip deal	$256 or less
Good one-way deal	$132 or less

Provider with most accurate pricing for Detroit Metropolitan Wayne County-Lambert-St Louis flight deals.

Search Deals

Provider most trusted by Cheapflights users for Detroit Metropolitan Wayne County-Lambert-St Louis flights.

Search Deals

From Detroit Metropolitan Wayne County to Lambert-St Louis

Search Deals

One-way flight from Detroit Metropolitan Wayne County to Lambert-St Louis

Search Deals

Highest demand for flights based on searches. 15% potential increase in price ($49 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 2% potential price decrease ($6 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in September 2025

Search Deals

Price to beat on a round-trip flight from Detroit Metropolitan Wayne County to Lambert-St Louis.

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Price to beat on a one-way flight from Detroit Metropolitan Wayne County to Lambert-St Louis.

Search Deals

Find flight deals from Detroit to St. Louis

Cheapest flights from Detroit to St. Louis
Explore the most affordable flight options available from Detroit to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 25, 2025.

Thu 10/234:58 pmDTW - STL

1 stop18h 18mFrontier

Thu 10/3011:07 amSTL - DTW

1 stop5h 05mFrontier

Deal found 9/23

$154

Sun 10/510:54 amDTW - STL

1 stop5h 10mFrontier

Thu 10/3011:07 amSTL - DTW

1 stop5h 05mFrontier

Deal found 9/25

$156

Tue 10/77:55 amDTW - STL

1 stop26h 12mFrontier

Fri 10/106:05 pmSTL - DTW

1 stop16h 12mFrontier

Deal found 9/23

$157

Mon 11/35:14 pmDTW - STL

1 stop16h 53mFrontier

Thu 11/67:45 pmSTL - DTW

1 stop19h 34mFrontier

Deal found 9/24

$159

Thu 10/211:54 amDTW - STL

1 stop22h 12mFrontier

Sun 10/51:57 pmSTL - DTW

1 stop17h 47mFrontier

Deal found 9/24

$172

Tue 10/215:30 amDTW - STL

1 stop9h 14mAmerican Airlines

Thu 10/237:16 amSTL - DTW

1 stop9h 18mAmerican Airlines

Deal found 9/23

$177

Wed 10/159:05 pmDTW - STL

1 stop14h 32mMultiple Airlines

Mon 10/206:05 pmSTL - DTW

2 stops13h 11mMultiple Airlines

Deal found 9/23

$179

Thu 10/211:54 amDTW - STL

1 stop22h 12mFrontier

Mon 10/64:00 pmSTL - DTW

1 stop21h 34mFrontier

Deal found 9/23

$183

Wed 10/229:05 pmDTW - STL

1 stop14h 32mMultiple Airlines

Wed 10/298:40 pmSTL - DTW

2 stops19h 32mMultiple Airlines

Deal found 9/24

$188

Thu 10/164:58 pmDTW - STL

1 stop18h 39mFrontier

Mon 10/207:52 pmSTL - DTW

1 stop28h 07mFrontier

Deal found 9/24

$189

Thu 11/69:20 pmDTW - STL

1 stop19h 41mMultiple Airlines

Mon 11/102:12 pmSTL - DTW

2 stops16h 48mMultiple Airlines

Deal found 9/24

$192

Best flights from Detroit to St. Louis
Discover carefully curated flight deals from Detroit to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 25, 2025.

Thu 10/234:58 pmDTW - STL

1 stop18h 18mMultiple Airlines

Thu 10/308:40 pmSTL - DTW

2 stops34h 36mMultiple Airlines

Deal found 9/23

$188

Thu 11/68:43 pmDTW - STL

1 stop4h 13mAmerican Airlines

Fri 11/74:42 pmSTL - DTW

1 stop6h 10mAmerican Airlines

Deal found 9/25

$223

Thu 10/168:05 pmDTW - STL

Nonstop1h 40mSouthwest

Mon 10/208:10 pmSTL - DTW

Nonstop1h 30mSouthwest

Deal found 9/23

$257

Tue 10/214:51 pmDTW - STL

Nonstop1h 38mDelta

Wed 10/2210:45 amSTL - DTW

Nonstop1h 32mDelta

Deal found 9/24

$257

Wed 11/59:20 pmDTW - STL

1 stop13h 52mMultiple Airlines

Fri 11/74:56 pmSTL - DTW

2 stops14h 26mMultiple Airlines

Deal found 9/22

$206

Mon 10/206:04 pmDTW - STL

1 stop6h 50mAmerican Airlines

Wed 10/226:00 amSTL - DTW

1 stop10h 34mAmerican Airlines

Deal found 9/25

$239

Sun 10/510:54 amDTW - STL

1 stop5h 10mMultiple Airlines

Thu 10/308:40 pmSTL - DTW

2 stops34h 36mMultiple Airlines

Deal found 9/25

$218

Thu 10/2312:45 pmDTW - STL

Nonstop1h 37mDelta

Thu 10/3010:45 amSTL - DTW

Nonstop1h 32mDelta

Deal found 9/23

$257

Mon 11/36:45 pmDTW - STL

Nonstop1h 40mSouthwest

Thu 11/65:10 amSTL - DTW

1 stop6h 00mSouthwest

Deal found 9/24

$267

Thu 11/137:59 pmDTW - STL

Nonstop1h 47mDelta

Mon 11/1710:45 amSTL - DTW

Nonstop1h 33mDelta

Deal found 9/25

$257

Thu 10/235:25 amDTW - STL

1 stop7h 05mSouthwest

Thu 10/307:45 amSTL - DTW

Nonstop1h 30mSouthwest

Deal found 9/23

$267

Mon 11/176:45 pmDTW - STL

Nonstop1h 40mSouthwest

Thu 11/207:00 amSTL - DTW

1 stop4h 20mSouthwest

Deal found 9/23

$267

Last-minute flights from Detroit to St. Louis
Discover last-minute flight deals from Detroit to St. Louis. Data last updated September 25, 2025 and is based on user searches.

Thu 10/211:54 amDTW - STL

1 stop22h 12mFrontier

Sun 10/51:57 pmSTL - DTW

1 stop17h 47mFrontier

Deal found 9/24

$172

Thu 10/211:54 amDTW - STL

1 stop22h 12mFrontier

Mon 10/64:00 pmSTL - DTW

1 stop21h 34mFrontier

Deal found 9/23

$183

Sun 10/510:54 amDTW - STL

1 stop5h 10mFrontier

Thu 10/3011:07 amSTL - DTW

1 stop5h 05mFrontier

Deal found 9/25

$156

Tue 10/77:55 amDTW - STL

1 stop26h 12mFrontier

Fri 10/106:05 pmSTL - DTW

1 stop16h 12mFrontier

Deal found 9/23

$157

Wed 10/159:05 pmDTW - STL

1 stop14h 32mMultiple Airlines

Mon 10/206:05 pmSTL - DTW

2 stops13h 11mMultiple Airlines

Deal found 9/23

$179

Thu 10/164:58 pmDTW - STL

1 stop18h 39mFrontier

Mon 10/207:52 pmSTL - DTW

1 stop28h 07mFrontier

Deal found 9/24

$189

Thu 10/164:58 pmDTW - STL

1 stop18h 39mMultiple Airlines

Mon 10/206:05 pmSTL - DTW

2 stops13h 11mMultiple Airlines

Deal found 9/24

$193

Tue 10/215:30 amDTW - STL

1 stop9h 14mAmerican Airlines

Tue 10/286:00 amSTL - DTW

1 stop10h 34mAmerican Airlines

Deal found 9/23

$177

Wed 10/229:05 pmDTW - STL

1 stop14h 32mMultiple Airlines

Wed 10/298:40 pmSTL - DTW

2 stops19h 32mMultiple Airlines

Deal found 9/24

$188

Thu 10/234:58 pmDTW - STL

1 stop18h 18mFrontier

Thu 10/3011:07 amSTL - DTW

1 stop5h 05mFrontier

Deal found 9/23

$154

One-way flights from Detroit to St. Louis
Search for one-way flight options from Detroit to St. Louis. Find affordable one-way fares based on user searches. Data last updated September 25, 2025.

Wed 10/229:05 pmDTW - STL

1 stop14h 32mMultiple Airlines

Deal found 9/25

$74

Fri 10/242:56 pmDTW - STL

1 stop8h 18mFrontier

Deal found 9/23

$80

Thu 10/234:58 pmDTW - STL

1 stop18h 18mFrontier

Deal found 9/23

$84

Fri 11/78:00 amDTW - STL

1 stop9h 01mMultiple Airlines

Deal found 9/23

$85

Sun 11/29:05 pmDTW - STL

1 stop13h 02mFrontier

Deal found 9/22

$86

Thu 11/69:20 pmDTW - STL

1 stop19h 41mMultiple Airlines

Deal found 9/23

$87

Tue 10/77:55 amDTW - STL

1 stop26h 12mFrontier

Deal found 9/23

$91

Tue 10/287:55 amDTW - STL

1 stop26h 12mFrontier

Deal found 9/23

$92

Sun 12/79:06 amDTW - STL

1 stop9h 25mFrontier

Deal found 9/22

$93

Mon 10/271:07 pmDTW - STL

1 stop8h 19mAmerican Airlines

Deal found 9/23

$94

Thu 12/119:06 amDTW - STL

1 stop9h 25mFrontier

Deal found 9/24

$95

Thu 1/89:00 amDTW - STL

1 stop6h 30mUnited Airlines

Deal found 9/24

$96

Cheapflights Fare Finder

Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Thu 10/23

4:58 pm-10:16 am

1 stop18h 18m

Lambert-St Louis

Thu 10/30

8:40 pm-8:16 am

2 stops34h 36m

$188

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Wed 11/5

9:20 pm-10:12 am

1 stop13h 52m

Lambert-St Louis

Fri 11/7

4:56 pm-8:22 am

2 stops14h 26m

$206

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Sun 10/5

10:54 am-3:04 pm

1 stop5h 10m

Lambert-St Louis

Thu 10/30

8:40 pm-8:16 am

2 stops34h 36m

$218

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Thu 11/6

8:43 pm-11:56 pm

1 stop4h 13m

Lambert-St Louis

Fri 11/7

4:42 pm-11:52 pm

1 stop6h 10m

$223

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Mon 10/20

6:04 pm-11:54 pm

1 stop6h 50m

Lambert-St Louis

Wed 10/22

6:00 am-5:34 pm

1 stop10h 34m

$239

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Thu 10/16

8:05 pm-8:45 pm

Nonstop1h 40m

Lambert-St Louis

Mon 10/20

8:10 pm-10:40 pm

Nonstop1h 30m

$257

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Tue 10/21

4:51 pm-5:29 pm

Nonstop1h 38m

Lambert-St Louis

Wed 10/22

10:45 am-1:17 pm

Nonstop1h 32m

$257

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Thu 10/23

12:45 pm-1:22 pm

Nonstop1h 37m

Lambert-St Louis

Thu 10/30

10:45 am-1:17 pm

Nonstop1h 32m

$257

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Thu 11/13

7:59 pm-8:46 pm

Nonstop1h 47m

Lambert-St Louis

Mon 11/17

10:45 am-1:18 pm

Nonstop1h 33m

$257

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Mon 11/3

6:45 pm-7:25 pm

Nonstop1h 40m

Lambert-St Louis

Thu 11/6

5:10 am-12:10 pm

1 stop6h 00m

$267

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/24

Showing 1-10 of 22 results

Compare providers for flights from Detroit to St. Louis

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Detroit to St. Louis in September.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy2 stars	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*3 stars
eDreams	Price Accuracy3 stars	Trust Score*3 stars
Justfly.com	Price Accuracy3 stars	Trust Score*3 stars
Priceline	Price Accuracy1 star	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Detroit Metropolitan Wayne County Airport-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Detroit Metropolitan Wayne County Airport-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Detroit Metropolitan Wayne County Airport-St. Louis flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Detroit Metropolitan Wayne County Airport-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Detroit Metropolitan Wayne County Airport-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

The best insider tips for Detroit Metropolitan Wayne County Airport to St. Louis flights

Cheapflights partnered with top experts to bring you the best recommendations for your Detroit Metropolitan Wayne County Airport to St. Louis trip

Airports

DTW

At DTW, security lines are generally short, with waits rarely exceeding 10 minutes in McNamara Terminal, making it efficient for business travelers.

STL

Use the MetroLink light rail from STL for a convenient, economical ride to downtown St. Louis, taking about 40 minutes.

Our travel experts

Brandon Schultz

Expert on DTW

Taryn White

Expert on STL

Best time to book a flight from Detroit to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Detroit with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Detroit Metropolitan Wayne County Airport to St. Louis

Prices

Airlines

How far ahead should I book a flight from Detroit Metropolitan Wayne County Airport to St. Louis?

The price you pay for your flight from Detroit Metropolitan Wayne County Airport to St. Louis may vary depending on when you book. For the best chance of a lower fare, look to book 54 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Detroit Metropolitan Wayne County Airport to St. Louis?

Currently, August is the cheapest month in which you can book a flight from Detroit Metropolitan Wayne County Airport to St. Louis (average of $311). Flying from Detroit Metropolitan Wayne County Airport to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DTW to STL?

Unlike in the morning, when flights are generally more expensive, you can save up to 20% on flights from Detroit Metropolitan Wayne County Airport to St. Louis by exploring options for tickets at noon.

What is the cheapest day to fly from Detroit Metropolitan Wayne County Airport to St. Louis?

Travelers seeking maximum savings on their Detroit Metropolitan Wayne County Airport to St. Louis flight should consider departing on Friday at noon when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing St. Louis

Read reviews from past customers who have flown Southwest, Delta, and United Airlines from Detroit Metropolitan Wayne County Airport to St. Louis. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Southwest

8.0

Very good

4,246 reviews

Reviews

1 / 20

2.0

Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Southwest

8.0

Very good

4,246 reviews

Southwest

8.0

Very good

4,246 reviews

Reviews

1 / 20

2.0

Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Delta

8.0

Very good

7,973 reviews

Southwest

8.0

Very good

4,246 reviews

Reviews

1 / 20

2.0

Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

United Airlines

7.4

Good

8,926 reviews

Southwest

8.0

Very good

4,246 reviews

Reviews

1 / 20

2.0

Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Spirit Airlines

6.3

Okay

8,045 reviews

Southwest

8.0

Very good

4,246 reviews

Reviews

1 / 20

2.0

Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

What airports do I use to fly from Detroit to St. Louis?
If you book a flight from Detroit to St. Louis, you will be flying from Detroit Metropolitan Wayne County to Lambert-St Louis. Flights to Lambert-St Louis (STL) from Detroit Metropolitan Wayne County (DTW) take 1h 35m for a nonstop flight. There are 11 flights from Detroit Metropolitan Wayne County to St. Louis per day from 4 airlines.
How long is the flight from Detroit Metropolitan Wayne County Airport to St. Louis?
For as low as $223, American Airlines can have you in St. Louis from Detroit Metropolitan Wayne County Airport in 4h 13m. Airlines will cover a distance of 439 mi.
What are the cheapest airlines flying from Detroit Metropolitan Wayne County Airport to St. Louis round-trip?
Our cheapest airline available from Detroit Metropolitan Wayne County Airport to St. Louis is Spirit Airlines. Our recent data shows that you can find tickets from as low as $36 on this airline. Additional options worth looking into are Delta and Southwest, starting at $140 and $148 round-trip. You may be able to fly from Detroit Metropolitan Wayne County Airport to St. Louis for 86% less than the average price by searching for these airlines.
What are the most reliable airlines from Detroit Metropolitan Wayne County Airport to St. Louis?
No one likes to see their flight delayed. When booking a flight from Detroit Metropolitan Wayne County Airport to St. Louis consider choosing SkyWest Airlines (100%), KLM (88%) or Southwest (86%) as they are the most reliable in getting you off to your destination on time.
What are the cheapest flights from Detroit Metropolitan Wayne County Airport to St. Louis?
On average you can expect to pay $260 for a flight from Detroit Metropolitan Wayne County Airport to St. Louis. The cheapest flight overall is $69 while the most popular route, (Detroit Metropolitan Wayne County - Lambert-St Louis) is currently priced at $165.
Can I find deals for flights from Detroit to St. Louis that include hotel bookings?
Yes. In addition to deals on Detroit to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Detroit to St. Louis?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Detroit to St. Louis.
Can I find deals for business class flights from Detroit to St. Louis?
Yes. Cheapflights offers flight deals from Detroit to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Detroit Metropolitan Wayne County Airport to St. Louis?
Currently, August is the cheapest month in which you can book a flight from Detroit Metropolitan Wayne County Airport to St. Louis (average of $311). Flying from Detroit Metropolitan Wayne County Airport to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Other flights to St. Louis

Top 4 airlines flying from Detroit to St. Louis

Airline	Cheapest	Average	Flexibility	On-time
Spirit Airlines	Cheapest$36	Average$101	FlexibilityNo cancel fee	On-time65%
Delta	Cheapest$140	Average$305	FlexibilityNo cancel fee	On-timeN/A
Southwest	Cheapest$148	Average$300	FlexibilityNo cancel fee	On-time63%
United Airlines	Cheapest$232	Average$476	FlexibilityNo cancel fee	On-time69%

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$74+ Cheap flights from Detroit Metropolitan Wayne County Airport to St. Louis (DTW - STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/22. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Detroit to St. Louis with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from Detroit Metropolitan Wayne County to Lambert-St Louis are usually found in July or August, booked 54 days in advance, depart on a Friday or Thursday and return on a Friday

Cheap flight deals from Detroit to St. Louis

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Good round-trip deal

Good one-way deal

Find flight deals from Detroit to St. Louis

Cheapest flights from Detroit to St. LouisExplore the most affordable flight options available from Detroit to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 25, 2025.

Explore the most affordable flight options available from Detroit to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 25, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to St. Louis that are best for you.

Compare providers for flights from Detroit to St. Louis

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

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The best insider tips for Detroit Metropolitan Wayne County Airport to St. Louis flights

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Best time to book a flight from Detroit to St. Louis

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Everything you need to know about your flight from Detroit Metropolitan Wayne County Airport to St. Louis

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Weekly flight availability from Detroit Metropolitan Wayne County Airport to St. Louis

Reviews of airlines servicing St. Louis

Related info for your journey

Find useful and relevant information for your journey from Detroit to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

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What are the cheapest flights from Detroit Metropolitan Wayne County Airport to St. Louis?

Can I find deals for flights from Detroit to St. Louis that include hotel bookings?

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What is the cheapest month to book a flight from Detroit Metropolitan Wayne County Airport to St. Louis?

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Alternative routes for Detroit to St. Louis

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Top 4 airlines flying from Detroit to St. Louis

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Cheapest flights from Detroit to St. Louis
Explore the most affordable flight options available from Detroit to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 25, 2025.