$54+ Cheap flights from Tampa (TPA) to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/12. Fares are subject to change and may not be available on all flights or dates of travel.
TPA — CHS
Dez 21 — Dez 281
1 adult, Economy
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Cheapest flights from Tampa to South CarolinaExplore the most affordable flight options available from Tampa to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 21, 2025.
Explore the most affordable flight options available from Tampa to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 21, 2025.
This Kiwi.com deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fr 12/126:12 pmTPA - CLT
Nonstop1h 48mFrontier
So 12/148:44 amCLT - TPA
Nonstop1h 54mFrontier
Deal found 11/20![Frontier logo]()
$109
This Priceline deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Do 12/117:15 amTPA - MYR
Nonstop1h 34mMultiple Airlines
Sa 12/139:54 amMYR - TPA
1 stop9h 01mMultiple Airlines
Deal found 11/20![Multiple Airlines logo]()
$112
This Super.com deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sa 12/68:09 amTPA - MYR
1 stop9h 39mSpirit Airlines
Di 12/99:54 amMYR - TPA
1 stop9h 01mSpirit Airlines
Deal found 11/19![Spirit Airlines logo]()
$118
This Kiwi.com deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mi 12/108:07 pmTPA - CLT
1 stop3h 52mMultiple Airlines
So 12/148:44 amCLT - TPA
Nonstop1h 54mMultiple Airlines
Deal found 11/20![Multiple Airlines logo]()
$120
This Priceline deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fr 12/126:12 pmTPA - CLT
Nonstop1h 48mFrontier
Fr 12/1210:38 pmCLT - TPA
1 stop9h 19mFrontier
Deal found 11/19![Frontier logo]()
$124
This Kiwi.com deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
So 12/1411:48 amTPA - CLT
Nonstop1h 48mMultiple Airlines
Mo 12/158:54 amCLT - TPA
1 stop22h 17mMultiple Airlines
Deal found 11/19![Multiple Airlines logo]()
$125
This Priceline deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Do 12/47:15 amTPA - MYR
Nonstop1h 34mMultiple Airlines
Mo 12/89:54 amMYR - TPA
1 stop9h 01mMultiple Airlines
Deal found 11/20![Multiple Airlines logo]()
$126
This Kiwi.com deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Do 12/48:09 amTPA - CLT
1 stop5h 54mSpirit Airlines
Mo 12/82:58 pmCLT - TPA
1 stop3h 57mSpirit Airlines
Deal found 11/20![Spirit Airlines logo]()
$126
This Kiwi.com deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Di 12/98:07 pmTPA - CLT
1 stop3h 52mSpirit Airlines
Sa 12/132:57 pmCLT - TPA
1 stop3h 58mSpirit Airlines
Deal found 11/19![Spirit Airlines logo]()
$128
This CheapOair deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Do 12/49:28 pmTPA - CLT
1 stop10h 31mFrontier
Fr 12/128:55 pmCLT - TPA
Nonstop1h 54mFrontier
Deal found 11/19![Frontier logo]()
$129
This Priceline deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Do 12/47:15 amTPA - MYR
Nonstop1h 34mBreeze Airways
Mo 12/82:14 pmMYR - TPA
Nonstop1h 42mBreeze Airways
Deal found 11/19![Breeze Airways logo]()
$130
This Cheapflightsfares deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mi 12/108:09 amTPA - CLT
1 stop5h 54mSpirit Airlines
Sa 12/132:57 pmCLT - TPA
1 stop3h 58mSpirit Airlines
Deal found 11/20![Spirit Airlines logo]()
$130
Cheap flight deals from Tampa to South Carolina
Keep the following information in mind while searching for Tampa to South Carolina flight deals. Data was last updated November 21, 2025.
Most accurate provider | Mytrip 3 stars |
|---|---|
Most trusted provider | Mytrip 3 stars |
Round-trip from | $108 (Super.com) |
One-way from | $54 (Super.com) |
Popular in | May |
Cheapest in | January |
Average price | $171 |
Good round-trip deal | $163 or less |
Good one-way deal | $48 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Tampa to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 21, 2025.
Use the filters below to find and compare flights from Tampa to South Carolina that are best for you.
Fly from
Tampa
Fly to
South Carolina
Route
Depart
Return
Price
TampaMyrtle Beach
TPA - MYR
TPAMYR
Tampa
Do 1/29
10:05 am-11:43 am
Nonstop1h 38m
Myrtle Beach Intl
Mo 2/2
6:09 pm-7:51 pm
Nonstop1h 42m
$118
TampaMyrtle Beach
TPA - MYR
TPAMYR
Tampa
Mo 1/12
10:05 am-11:43 am
Nonstop1h 38m
Myrtle Beach Intl
Fr 1/16
6:09 pm-7:51 pm
Nonstop1h 42m
$118
TampaGreenville
TPA - GSP
TPAGSP
Tampa
Fr 1/9
6:27 pm-8:07 pm
Nonstop1h 40m
Greenville
Mo 1/12
4:07 pm-5:47 pm
Nonstop1h 40m
$119
TampaCharlotte
TPA - CLT
TPACLT
Tampa
Do 1/8
9:19 pm-7:59 am
1 stop10h 40m
Charlotte Douglas
Fr 1/9
1:47 pm-8:37 pm
1 stop6h 50m
$124
TampaMyrtle Beach
TPA - MYR
TPAMYR
Tampa
Sa 12/6
8:09 am-5:48 pm
1 stop9h 39m
Myrtle Beach Intl
Fr 12/12
2:14 pm-3:56 pm
Nonstop1h 42m
$126
TampaMyrtle Beach
TPA - MYR
TPAMYR
Tampa
Do 12/4
7:15 am-8:49 am
Nonstop1h 34m
Myrtle Beach Intl
Fr 12/12
2:14 pm-3:56 pm
Nonstop1h 42m
$126
TampaCharlotte
TPA - CLT
TPACLT
Tampa
Do 12/4
8:09 am-2:03 pm
1 stop5h 54m
Charlotte Douglas
Fr 12/5
2:58 pm-6:55 pm
1 stop3h 57m
$130
TampaCharlotte
TPA - CLT
TPACLT
Tampa
Sa 12/6
8:07 pm-11:59 pm
1 stop3h 52m
Charlotte Douglas
Mo 12/8
2:58 pm-6:55 pm
1 stop3h 57m
$133
TampaCharlotte
TPA - CLT
TPACLT
Tampa
Fr 1/23
10:10 am-12:01 pm
Nonstop1h 51m
Charlotte Douglas
Di 2/3
7:00 am-5:33 pm
1 stop10h 33m
$135
TampaCharleston
TPA - CHS
TPACHS
Tampa
Do 12/4
1:00 pm-2:28 pm
Nonstop1h 28m
Charleston
Mo 12/8
9:23 pm-10:52 pm
Nonstop1h 29m
$138
Showing 1-10 of 60 results
Best time to book a flight from Tampa to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Tampa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Tampa to South Carolina
What is the cheapest month to book a flight from Tampa to South Carolina?
Currently, May is the cheapest month in which you can book a flight from Tampa to South Carolina (average of $39). Flying from Tampa to South Carolina in January is currently the most expensive (average of $76). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from TPA to SC?
Find hourly flight availability from Tampa to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 21, 2025.
Unlike in the evening, when flights are generally more expensive, you can save up to 11% on flights from Tampa to South Carolina by exploring options for tickets at noon.
What is the cheapest day to fly from Tampa to South Carolina?
Use this chart to determine the cheapest time to fly round-trip from Tampa to South Carolina. Price data was last updated on December 16, 2024.
Travelers seeking maximum savings on their Tampa to South Carolina flight should consider departing on Friday mornings when fares are most often at their lowest. Thursday at noon flights should be avoided if possible as fares are typically the most expensive at this time.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated November 21, 2025.
See what other customers who have flown with Breeze Airways, Delta, and American Airlines from Tampa to South Carolina have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
6.7
Comfort
8.2
Entertainment
6.7
Boarding
8.3
Overall
8.2
Crew
8.8
Reviews
1 / 14
10.0
ExcellentKim,Nov 2025
PWM - RSW
Food
6.7
Comfort
8.2
Entertainment
6.7
Boarding
8.3
Overall
8.2
Crew
8.8
Reviews
1 / 14
10.0
ExcellentKim,Nov 2025
PWM - RSW
Food
6.7
Comfort
8.2
Entertainment
6.7
Boarding
8.3
Overall
8.2
Crew
8.8
Reviews
1 / 14
10.0
ExcellentKim,Nov 2025
PWM - RSW
Food
6.7
Comfort
8.2
Entertainment
6.7
Boarding
8.3
Overall
8.2
Crew
8.8
Reviews
1 / 14
10.0
ExcellentKim,Nov 2025
PWM - RSW
Food
6.7
Comfort
8.2
Entertainment
6.7
Boarding
8.3
Overall
8.2
Crew
8.8
Reviews
1 / 14
10.0
ExcellentKim,Nov 2025
PWM - RSW
Food
6.7
Comfort
8.2
Entertainment
6.7
Boarding
8.3
Overall
8.2
Crew
8.8
Reviews
1 / 14
10.0
ExcellentKim,Nov 2025
PWM - RSW
Related info for your journey
Find useful and relevant information for your journey from Tampa to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
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Alternative routes for Tampa to South Carolina
See prices for flight routes from nearby airports that may be better suited for you.
Top 6 airlines flying from Tampa to South Carolina
Discover the top 6 airlines that operate flights from Tampa to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 21, 2025.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$78 | Average$99 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$86 | Average$179 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$95 | Average$184 | FlexibilityNo cancel fee | On-time65% | |
| Cheapest$115 | Average$308 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$156 | Average$366 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$176 | Average$345 | FlexibilityNo cancel fee | On-time71% |