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$264+ Cheap flights from Santa Fe (SAF) to South Carolina

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/12. Fares are subject to change and may not be available on all flights or dates of travel.
SAF — CHS
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
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Cheap flight deals from Santa Fe to South Carolina

Keep the following information in mind while searching for Santa Fe to South Carolina flight deals. Data was last updated October 30, 2025.

Round-trip from

$264
(American Airlines)
From Santa Fe to South Carolina
Search Deals

Find flight deals from Santa Fe to South Carolina

Cheapest flights from Santa Fe to South Carolina
Explore the most affordable flight options available from Santa Fe to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/141:26 pmSAF - CLT
1 stop7h 27mUnited Airlines
Tue 11/188:15 amCLT - SAF
1 stop8h 27mUnited Airlines
Deal found 10/29$334
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/106:15 amSAF - HHH
2 stops10h 18mAmerican Airlines
Sat 12/1311:47 amHHH - SAF
2 stops12h 01mAmerican Airlines
Deal found 10/29$429
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/245:16 pmSAF - CLT
1 stop5h 31mAmerican Airlines
Sun 11/305:23 amCLT - SAF
1 stop6h 05mAmerican Airlines
Deal found 10/30$624
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/256:31 pmSAF - CLT
1 stop8h 34mAmerican Airlines
Sun 11/305:23 amCLT - SAF
1 stop6h 05mAmerican Airlines
Deal found 10/30$635
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/207:00 amSAF - GSP
2 stops14h 56mUnited Airlines
Wed 11/264:56 pmGSP - SAF
2 stops18h 29mUnited Airlines
Deal found 10/30$702
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/2510:48 amSAF - CLT
2 stops11h 10mUnited Airlines
Sun 11/308:15 amCLT - SAF
1 stop10h 42mUnited Airlines
Deal found 10/30$942
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/237:00 amSAF - CHS
1 stop6h 09mUnited Airlines
Mon 12/294:05 pmCHS - SAF
1 stop7h 54mUnited Airlines
Deal found 10/29$1,309

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santa Fe to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Santa Fe to South Carolina that are best for you.

Fly from

Santa Fe

Fly to

South Carolina

Route

Depart

Return

Price

Santa FeCharleston

SAF - CHS

SAFCHS

Santa Fe

Mon 1/12

6:25 am-2:25 pm

1 stop6h 00m

Charleston

Tue 1/20

7:32 am-12:29 pm

1 stop6h 57m

$264

Santa FeCharlotte

SAF - CLT

SAFCLT

Santa Fe

Fri 11/14

1:26 pm-10:53 pm

1 stop7h 27m

Charlotte Douglas

Tue 11/18

8:15 am-2:42 pm

1 stop8h 27m

$334

Santa FeSavannah

SAF - SAV

SAFSAV

Santa Fe

Mon 1/12

7:00 am-10:46 pm

2 stops13h 46m

Savannah/Hilton Head

Tue 1/20

10:10 am-8:47 pm

2 stops12h 37m

$349

Santa FeCharlotte

SAF - CLT

SAFCLT

Santa Fe

Sat 4/11

1:26 pm-10:42 pm

1 stop7h 16m

Charlotte Douglas

Wed 4/15

4:05 pm-10:01 pm

1 stop7h 56m

$414

Santa FeHilton Head Island

SAF - HHH

SAFHHH

Santa Fe

Wed 12/10

6:15 am-6:33 pm

2 stops10h 18m

Hilton Head Island

Sat 12/13

11:47 am-9:48 pm

2 stops12h 01m

$429

Santa FeCharleston

SAF - CHS

SAFCHS

Santa Fe

Tue 3/3

6:15 am-2:53 pm

1 stop6h 38m

Charleston

Sat 3/7

3:46 pm-8:50 pm

1 stop7h 04m

$444

Santa FeGreenville

SAF - GSP

SAFGSP

Santa Fe

Sat 2/28

6:15 am-3:35 pm

1 stop7h 20m

Greenville

Tue 3/3

4:25 pm-8:50 pm

1 stop6h 25m

$455

Santa FeGreenville

SAF - GSP

SAFGSP

Santa Fe

Sat 2/28

6:00 pm-10:06 am

2 stops14h 06m

Greenville

Tue 3/3

6:30 am-12:48 pm

2 stops8h 18m

$478

Santa FeSavannah

SAF - SAV

SAFSAV

Santa Fe

Mon 1/12

6:25 am-3:17 pm

1 stop6h 52m

Savannah/Hilton Head

Tue 1/20

7:12 am-12:29 pm

1 stop7h 17m

$518

Santa FeCharleston

SAF - CHS

SAFCHS

Santa Fe

Mon 1/12

7:00 am-3:05 pm

1 stop6h 05m

Charleston

Fri 1/16

7:45 pm-12:41 pm

2 stops18h 56m

$558

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/30

Showing 1-10 of 21 results
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Best time to book a flight from Santa Fe to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Santa Fe with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santa Fe to South Carolina

What is the cheapest month to book a flight from Santa Fe to South Carolina?

Currently, November is the cheapest month in which you can book a flight from Santa Fe to South Carolina (average of $263). Flying from Santa Fe to South Carolina in January is currently the most expensive (average of $393). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Santa Fe to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Santa Fe to South Carolina?

    Most people fly from Santa Fe (SAF) if they book a flight from Santa Fe to South Carolina. Santa Fe is conveniently located just 9.8 mi from Santa Fe’s city center.

  • How long is the flight from Santa Fe to South Carolina?

    A quick flight from Santa Fe to South Carolina can take about 6h. American Airlines provides one of the quickest options available for as low as $264. Airlines will cover a distance of 1494 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Santa Fe to South Carolina?

    When deciding which route to take from Santa Fe to South Carolina consider Santa Fe - Savannah/Hilton Head, Santa Fe - Charleston or Santa Fe - Charlotte Douglas as they are the most popular.

  • Can I find deals for flights from Santa Fe to South Carolina that include hotel bookings?

    Yes. In addition to deals on Santa Fe to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santa Fe to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santa Fe to South Carolina.

  • Can I find deals for business class flights from Santa Fe to South Carolina?

    Yes. Cheapflights offers flight deals from Santa Fe to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santa Fe to South Carolina?

    Currently, November is the cheapest month in which you can book a flight from Santa Fe to South Carolina (average of $263). Flying from Santa Fe to South Carolina in January is currently the most expensive (average of $393). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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