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South Carolina

$269+ Cheap flights from Santa Fe (SAF) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/14. Fares are subject to change and may not be available on all flights or dates of travel.
SAF — CHS
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheap flight deals from Santa Fe to South Carolina

Keep the following information in mind while searching for Santa Fe to South Carolina flight deals. Data was last updated September 15, 2025.

Round-trip from

$324
(American Airlines)

One-way from

$269
(American Airlines)
From Santa Fe to South Carolina
Search Deals
One-way flight from Santa Fe to South Carolina
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Find flight deals from Santa Fe to South Carolina

Cheapest flights from Santa Fe to South Carolina
Explore the most affordable flight options available from Santa Fe to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/216:15 amSAF - CHS
1 stop5h 21mAmerican Airlines
Tue 10/2812:15 pmCHS - SAF
2 stops10h 46mAmerican Airlines
Deal found 9/13$324
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/17:10 amSAF - CHS
2 stops10h 58mUnited Airlines
Sat 10/114:35 pmCHS - SAF
1 stop7h 28mUnited Airlines
Deal found 9/13$389
This American Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/277:15 amSAF - GSP
1 stop7h 42mAmerican Airlines
Wed 10/16:33 pmGSP - SAF
1 stop5h 23mAmerican Airlines
Deal found 9/12$394
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/177:24 pmSAF - CLT
1 stop8h 29mAmerican Airlines
Mon 10/207:05 amCLT - SAF
1 stop11h 01mAmerican Airlines
Deal found 9/14$403
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/12:05 pmSAF - CHS
1 stop6h 39mAmerican Airlines
Sat 10/112:26 pmCHS - SAF
1 stop8h 35mAmerican Airlines
Deal found 9/14$410
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/187:20 pmSAF - CLT
1 stop7h 53mAmerican Airlines
Sat 9/205:30 amCLT - SAF
1 stop7h 47mAmerican Airlines
Deal found 9/14$434
This American Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/106:15 amSAF - HHH
2 stops10h 23mAmerican Airlines
Sat 12/1311:47 amHHH - SAF
2 stops12h 01mAmerican Airlines
Deal found 9/12$434
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/187:00 amSAF - CLT
1 stop6h 11mUnited Airlines
Sat 9/206:00 amCLT - SAF
2 stops13h 09mUnited Airlines
Deal found 9/14$459
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/175:59 pmSAF - CLT
1 stop19h 14mUnited Airlines
Mon 10/2010:25 amCLT - SAF
2 stops24h 59mUnited Airlines
Deal found 9/14$533
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/97:24 pmSAF - CLT
1 stop7h 36mAmerican Airlines
Sun 10/127:05 amCLT - SAF
1 stop11h 01mAmerican Airlines
Deal found 9/13$557
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/117:10 amSAF - SAV
2 stops25h 22mUnited Airlines
Sat 10/187:10 amSAV - SAF
2 stops28h 14mUnited Airlines
Deal found 9/13$613
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1110:21 amSAF - SAV
1 stop10h 55mAmerican Airlines
Sat 10/182:08 pmSAV - SAF
1 stop10h 02mAmerican Airlines
Deal found 9/13$633

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santa Fe to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Santa Fe to South Carolina that are best for you.

Fly from

Santa Fe

Fly to

South Carolina

Route

Depart

Return

Price

Santa FeCharleston

SAF - CHS

SAFCHS

Santa Fe

Tue 10/21

6:15 am-1:36 pm

1 stop5h 21m

Charleston

Tue 10/28

6:30 am-2:56 pm

2 stops10h 26m

$324

Santa FeCharleston

SAF - CHS

SAFCHS

Santa Fe

Wed 10/1

7:10 am-8:08 pm

2 stops10h 58m

Charleston

Sat 10/11

4:35 pm-10:03 pm

1 stop7h 28m

$389

Santa FeGreenville

SAF - GSP

SAFGSP

Santa Fe

Sat 9/27

7:15 am-4:57 pm

1 stop7h 42m

Greenville

Wed 10/1

6:33 pm-9:56 pm

1 stop5h 23m

$394

Santa FeCharlotte

SAF - CLT

SAFCLT

Santa Fe

Fri 10/17

7:24 pm-5:53 am

1 stop8h 29m

Charlotte Douglas

Mon 10/20

7:05 am-4:06 pm

1 stop11h 01m

$403

Santa FeCharleston

SAF - CHS

SAFCHS

Santa Fe

Wed 10/1

2:05 pm-10:44 pm

1 stop6h 39m

Charleston

Sat 10/11

2:26 pm-9:01 pm

1 stop8h 35m

$410

Santa FeHilton Head Island

SAF - HHH

SAFHHH

Santa Fe

Wed 12/10

6:15 am-6:38 pm

2 stops10h 23m

Hilton Head Island

Sat 12/13

11:47 am-9:48 pm

2 stops12h 01m

$434

Santa FeSavannah

SAF - SAV

SAFSAV

Santa Fe

Tue 3/3

7:00 am-6:52 pm

2 stops9h 52m

Savannah/Hilton Head

Sat 3/7

7:17 pm-8:32 am

2 stops15h 15m

$503

Santa FeCharlotte

SAF - CLT

SAFCLT

Santa Fe

Fri 10/17

5:59 pm-3:13 pm

1 stop19h 14m

Charlotte Douglas

Mon 10/20

10:25 am-9:24 am

2 stops24h 59m

$533

Santa FeCharlotte

SAF - CLT

SAFCLT

Santa Fe

Thu 10/9

7:24 pm-5:00 am

1 stop7h 36m

Charlotte Douglas

Sun 10/12

7:05 am-4:06 pm

1 stop11h 01m

$557

Santa FeSavannah

SAF - SAV

SAFSAV

Santa Fe

Tue 3/3

5:04 pm-10:14 am

2 stops15h 10m

Savannah/Hilton Head

Sat 3/7

7:24 am-11:04 am

1 stop5h 40m

$577

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Showing 1-10 of 17 results
1
2

Best time to book a flight from Santa Fe to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Santa Fe with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santa Fe to South Carolina

What is the cheapest month to book a flight from Santa Fe to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Santa Fe to South Carolina (average of $217). Flying from Santa Fe to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated September 15, 2025.
See what other customers who have flown with American Airlines from Santa Fe to South Carolina have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
10,000 reviews

Food

6.4

Comfort

7.2

Entertainment

6.9

Overall

7.2

Boarding

7.5

Crew

8.0

Reviews

1 / 20
2.0
Mediocre

Jeremy,Sep 2025

SAN - PHL

Terrible. Bad customer service and unacceptable delay on the tarmac
American Airlines
7.2
Good
10,000 reviews
American Airlines
7.2
Good
10,000 reviews

Food

6.4

Comfort

7.2

Entertainment

6.9

Overall

7.2

Boarding

7.5

Crew

8.0

Reviews

1 / 20
2.0
Mediocre

Jeremy,Sep 2025

SAN - PHL

Terrible. Bad customer service and unacceptable delay on the tarmac

Related info for your journey

Find useful and relevant information for your journey from Santa Fe to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Santa Fe to South Carolina?

    Most people fly from Santa Fe (SAF) if they book a flight from Santa Fe to South Carolina. Santa Fe is conveniently located just 9.8 mi from Santa Fe’s city center.

  • How long is the flight from Santa Fe to South Carolina?

    A quick flight from Santa Fe to South Carolina can take about 5h 21m. American Airlines provides one of the quickest options available for as low as $324. Airlines will cover a distance of 1494 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Santa Fe to South Carolina?

    When deciding which route to take from Santa Fe to South Carolina consider Santa Fe - Charleston, Santa Fe - Charlotte Douglas or Santa Fe - Greenville as they are the most popular.

  • Can I find deals for flights from Santa Fe to South Carolina that include hotel bookings?

    Yes. In addition to deals on Santa Fe to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santa Fe to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santa Fe to South Carolina.

  • Can I find deals for business class flights from Santa Fe to South Carolina?

    Yes. Cheapflights offers flight deals from Santa Fe to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santa Fe to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Santa Fe to South Carolina (average of $217). Flying from Santa Fe to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Santa Fe to South Carolina

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Top airline flying from Santa Fe to South Carolina

Discover the top airline that operate flights from Santa Fe to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$374Average$613FlexibilityNo cancel feeOn-time71%

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