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South Carolina

$285+ Cheap flights from Santa Fe (SAF) to South Carolina

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/16. Fares are subject to change and may not be available on all flights or dates of travel.
SAF — CHS
Feb 27 — Mar 61
Fri 2/27
Fri 3/6
1 adult, Economy
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Cheap flight deals from Santa Fe to South Carolina

Cheapest flights from Santa Fe to South Carolina
Explore the most affordable flight options available from Santa Fe to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 28, 2026.

This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/166:42 pm
SAF
-
CLT
1 stop9h 14m
American Airlines
Sun 2/227:25 am
CLT
-
SAF
1 stop9h 40m
American Airlines
Deal found 1/26$285
This American Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/286:15 am
SAF
-
CHS
1 stop6h 40m
American Airlines
Tue 3/33:45 pm
CHS
-
SAF
1 stop7h 03m
American Airlines
Deal found 1/28$385
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/282:04 pm
SAF
-
CHS
1 stop6h 37m
American Airlines
Sat 5/27:00 am
CHS
-
SAF
1 stop7h 06m
American Airlines
Deal found 1/26$411
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/37:00 am
SAF
-
CLT
1 stop6h 16m
United Airlines
Sat 2/78:00 am
CLT
-
SAF
1 stop6h 39m
United Airlines
Deal found 1/27$484
This United Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/107:00 am
SAF
-
GSP
1 stop6h 20m
United Airlines
Sat 2/144:16 pm
GSP
-
SAF
1 stop6h 15m
United Airlines
Deal found 1/26$485
This United Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/1010:45 am
SAF
-
SAV
2 stops10h 01m
United Airlines
Sat 2/144:02 pm
SAV
-
SAF
1 stop6h 29m
United Airlines
Deal found 1/25$530
This United Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/37:00 am
SAF
-
CHS
1 stop6h 05m
United Airlines
Sat 2/710:30 am
CHS
-
SAF
2 stops8h 26m
United Airlines
Deal found 1/25$565
This United Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/167:00 am
SAF
-
CLT
2 stops12h 09m
United Airlines
Sun 2/226:15 am
CLT
-
SAF
2 stops10h 30m
United Airlines
Deal found 1/26$1,199

Find flight deals from Santa Fe to South Carolina

Keep the following information in mind while searching for Santa Fe to South Carolina flight deals. Data was last updated January 28, 2026.

Round-trip from

$285
(American Airlines)
From Santa Fe to South Carolina
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santa Fe to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 28, 2026.
Use the filters below to find and compare flights from Santa Fe to South Carolina that are best for you.

Fly from

Santa Fe

Fly to

South Carolina

Route

Depart

Return

Price

Santa FeCharlotte

SAF - CLT

SAFCLT

Santa Fe

Mon 2/16

6:42 pm-5:56 am

1 stop9h 14m

Charlotte Douglas

Sun 2/22

7:25 am-3:05 pm

1 stop9h 40m

$285

Santa FeCharleston

SAF - CHS

SAFCHS

Santa Fe

Sat 2/28

6:15 am-2:55 pm

1 stop6h 40m

Charleston

Tue 3/3

3:45 pm-8:48 pm

1 stop7h 03m

$385

Santa FeCharleston

SAF - CHS

SAFCHS

Santa Fe

Tue 4/28

2:04 pm-10:41 pm

1 stop6h 37m

Charleston

Sat 5/2

7:00 am-12:06 pm

1 stop7h 06m

$411

Santa FeGreenville

SAF - GSP

SAFGSP

Santa Fe

Tue 2/10

7:00 am-3:20 pm

1 stop6h 20m

Greenville

Sat 2/14

4:16 pm-8:31 pm

1 stop6h 15m

$485

Santa FeSavannah

SAF - SAV

SAFSAV

Santa Fe

Tue 2/10

10:45 am-10:46 pm

2 stops10h 01m

Savannah/Hilton Head

Sat 2/14

4:02 pm-8:31 pm

1 stop6h 29m

$530

Santa FeCharlotte

SAF - CLT

SAFCLT

Santa Fe

Mon 2/16

7:00 am-9:09 pm

2 stops12h 09m

Charlotte Douglas

Sun 2/22

6:15 am-2:45 pm

2 stops10h 30m

$1,199

Santa FeCharlotte

SAF - CLT

SAFCLT

Santa Fe

Sat 4/11

6:40 pm-6:06 am

1 stop9h 26m

$299

Santa FeCharlotte

SAF - CLT

SAFCLT

Santa Fe

Thu 4/9

6:15 am-4:29 pm

1 stop8h 14m

$299

Santa FeCharleston

SAF - CHS

SAFCHS

Santa Fe

Tue 5/12

7:00 am-3:14 pm

1 stop6h 14m

$300

Santa FeCharleston

SAF - CHS

SAFCHS

Santa Fe

Mon 4/13

1:19 pm-9:37 pm

1 stop6h 18m

$300

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/27

Showing 1-10 of 19 results
1
2

Best time to book a flight from Santa Fe to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Santa Fe with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santa Fe to South Carolina

What is the cheapest month to book a flight from Santa Fe to South Carolina?

Currently, November is the cheapest month in which you can book a flight from Santa Fe to South Carolina (average of $228). Flying from Santa Fe to South Carolina in March is currently the most expensive (average of $354). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated January 28, 2026.
See what other customers who have flown with American Airlines from Santa Fe to South Carolina have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,201 reviews

Comfort

7.2

Entertainment

6.9

Overall

7.2

Crew

8.0

Food

6.4

Boarding

7.5

Reviews

1 / 20
2.0
Mediocre

Susie,Jan 2026

CLT - TPA

This flight was delayed 3 or 4 times. We had boarded the plane, sat on plane for a good 30 minutes, then we had to board the aircraft, walk to a different gate, wait and then board another aircraft. We arrived in Tampa 4 hours later than the original booking. I feel there should have been some sort of compensation especially for the advantage members.
American Airlines
7.2
Good
11,201 reviews
American Airlines
7.2
Good
11,201 reviews

Comfort

7.2

Entertainment

6.9

Overall

7.2

Crew

8.0

Food

6.4

Boarding

7.5

Reviews

1 / 20
2.0
Mediocre

Susie,Jan 2026

CLT - TPA

This flight was delayed 3 or 4 times. We had boarded the plane, sat on plane for a good 30 minutes, then we had to board the aircraft, walk to a different gate, wait and then board another aircraft. We arrived in Tampa 4 hours later than the original booking. I feel there should have been some sort of compensation especially for the advantage members.

Related info for your journey

Find useful and relevant information for your journey from Santa Fe to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Santa Fe to South Carolina?

    Most people fly from Santa Fe (SAF) if they book a flight from Santa Fe to South Carolina. Santa Fe is conveniently located just 9.8 mi from Santa Fe’s city center.

  • How long is the flight from Santa Fe to South Carolina?

    A quick flight from Santa Fe to South Carolina can take about 6h 20m. American Airlines provides one of the quickest options available for as low as $485. Airlines will cover a distance of 1343 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Santa Fe to South Carolina?

    When deciding which route to take from Santa Fe to South Carolina consider Santa Fe - Charleston, Santa Fe - Charlotte Douglas or Santa Fe - Greenville as they are the most popular.

  • Can I find deals for flights from Santa Fe to South Carolina that include hotel bookings?

    Yes. In addition to deals on Santa Fe to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santa Fe to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santa Fe to South Carolina.

  • Can I find deals for business class flights from Santa Fe to South Carolina?

    Yes. Cheapflights offers flight deals from Santa Fe to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santa Fe to South Carolina?

    Currently, November is the cheapest month in which you can book a flight from Santa Fe to South Carolina (average of $228). Flying from Santa Fe to South Carolina in March is currently the most expensive (average of $354). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top airline flying from Santa Fe to South Carolina

Discover the top airline that operate flights from Santa Fe to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 28, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$264Average$523FlexibilityNo cancel feeOn-time71%

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