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$161+ Cheap flights from Odessa, TX to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/21. Fares are subject to change and may not be available on all flights or dates of travel.
MAF — CHS
nov. 29 — dic. 61
sáb. 11/29
sáb. 12/6
1 adult, Economy
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Cheap flight deals from Odessa to South Carolina

Keep the following information in mind while searching for Odessa to South Carolina flight deals. Data was last updated octubre 30, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$364
(Southwest)

One-way from

$161
(United Airlines)
Provider with most accurate pricing for Midland Intl-Myrtle Beach Intl flight deals.
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Provider most trusted by Cheapflights users for Midland Intl-Myrtle Beach Intl flights.
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From Odessa to South Carolina
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One-way flight from Odessa to South Carolina
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Find flight deals from Odessa to South Carolina

Cheapest flights from Odessa to South Carolina
Explore the most affordable flight options available from Odessa to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on octubre 30, 2025.

This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 11/21:55 pmMAF - CLT
1 stop7h 58mUnited Airlines
vie. 11/74:17 pmCLT - MAF
1 stop6h 48mUnited Airlines
Deal found 10/29$351
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 11/212:33 pmMAF - CLT
2 stops10h 17mDelta
vie. 11/75:30 amCLT - MAF
2 stops7h 23mDelta
Deal found 10/29$361
This Southwest deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/304:00 pmMAF - SAV
2 stops6h 20mSouthwest
mar. 1/66:05 amSAV - MAF
2 stops9h 05mSouthwest
Deal found 10/27$397
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 11/15:45 amMAF - CLT
2 stops12h 55mSouthwest
vie. 11/77:40 amCLT - MAF
1 stop9h 50mSouthwest
Deal found 10/29$431
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 11/129:13 amMAF - SAV
1 stop4h 41mAmerican Airlines
dom. 11/167:25 pmSAV - MAF
1 stop5h 30mAmerican Airlines
Deal found 10/28$447
This Southwest deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/131:55 pmMAF - SAV
2 stops8h 00mSouthwest
lun. 11/177:50 amSAV - MAF
1 stop5h 40mSouthwest
Deal found 10/28$472
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 11/141:55 pmMAF - CLT
1 stop7h 58mUnited Airlines
dom. 11/166:45 amCLT - MAF
1 stop5h 39mUnited Airlines
Deal found 10/29$483
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/306:00 amMAF - SAV
1 stop15h 08mAmerican Airlines
mar. 1/64:33 pmSAV - MAF
1 stop5h 16mAmerican Airlines
Deal found 10/27$518
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 11/142:15 pmMAF - CLT
2 stops6h 55mSouthwest
dom. 11/167:40 amCLT - MAF
2 stops8h 10mSouthwest
Deal found 10/29$519
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 11/210:00 amMAF - CLT
2 stops8h 00mSouthwest
sáb. 11/88:15 amCLT - MAF
1 stop5h 10mSouthwest
Deal found 10/29$555
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 11/210:00 amMAF - CLT
1 stop8h 15mSouthwest
vie. 11/77:40 amCLT - MAF
1 stop9h 50mSouthwest
Deal found 10/29$640
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 11/127:56 amMAF - SAV
3 stops15h 00mUnited Airlines
dom. 11/167:04 amSAV - MAF
2 stops15h 59mUnited Airlines
Deal found 10/28$697

Cheapflights Fare Finder

 
Customize your flight search to find flights from Odessa to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 30, 2025.
Use the filters below to find and compare flights from Odessa to South Carolina that are best for you.

Fly from

Odessa

Fly to

South Carolina

Route

Depart

Return

Price

MidlandCharlotte

MAF - CLT

MAFCLT

Midland Intl

dom. 11/2

1:55 pm-10:53 pm

1 stop7h 58m

Charlotte Douglas

vie. 11/7

4:17 pm-10:05 pm

1 stop6h 48m

$351

MidlandCharlotte

MAF - CLT

MAFCLT

Midland Intl

dom. 11/2

12:33 pm-11:50 pm

2 stops10h 17m

Charlotte Douglas

vie. 11/7

5:30 am-11:53 am

2 stops7h 23m

$361

MidlandCharlotte

MAF - CLT

MAFCLT

Midland Intl

dom. 11/2

12:33 pm-11:50 pm

2 stops10h 17m

Charlotte Douglas

sáb. 11/8

6:15 am-11:53 am

2 stops6h 38m

$361

MidlandCharlotte

MAF - CLT

MAFCLT

Midland Intl

mié. 1/21

11:05 am-5:20 pm

1 stop5h 15m

Charlotte Douglas

dom. 1/25

12:55 pm-9:20 pm

1 stop9h 25m

$364

MidlandSavannah

MAF - SAV

MAFSAV

Midland Intl

mar. 12/30

4:00 pm-11:20 pm

2 stops6h 20m

Savannah/Hilton Head

mar. 1/6

6:05 am-2:10 pm

2 stops9h 05m

$397

MidlandCharlotte

MAF - CLT

MAFCLT

Midland Intl

dom. 11/2

7:00 am-11:58 pm

3 stops15h 58m

Charlotte Douglas

sáb. 11/8

10:43 am-6:15 pm

2 stops8h 32m

$446

MidlandCharlotte

MAF - CLT

MAFCLT

Midland Intl

vie. 11/14

2:15 pm-10:10 pm

2 stops6h 55m

Charlotte Douglas

dom. 11/16

7:40 am-4:30 pm

1 stop9h 50m

$446

MidlandSavannah

MAF - SAV

MAFSAV

Midland Intl

mié. 11/12

9:13 am-2:54 pm

1 stop4h 41m

Savannah/Hilton Head

dom. 11/16

7:25 pm-11:55 pm

1 stop5h 30m

$447

MidlandSavannah

MAF - SAV

MAFSAV

Midland Intl

jue. 11/13

1:55 pm-10:55 pm

2 stops8h 00m

Savannah/Hilton Head

lun. 11/17

7:50 am-12:30 pm

1 stop5h 40m

$472

MidlandCharlotte

MAF - CLT

MAFCLT

Midland Intl

vie. 11/14

1:55 pm-10:53 pm

1 stop7h 58m

Charlotte Douglas

dom. 11/16

6:45 am-11:24 am

1 stop5h 39m

$483

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/29

Showing 1-10 of 18 results
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Best time to book a flight from Odessa to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Odessa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Odessa to South Carolina
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Odessa to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Odessa to South Carolina?

    For as low as $397, United Airlines can have you in South Carolina from Odessa in 6h 20m. There are 1227 mi between Odessa and South Carolina. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Odessa to South Carolina one-way?

    One-way options have recently been found by users for as low as $161 on United Airlines. Other airlines that offer cheap prices include American Airlines from $161 and Southwest from $166 one-way.

  • What are the most popular routes from Odessa to South Carolina?

    While some choose either Midland Intl - Myrtle Beach Intl or Midland Intl - Savannah/Hilton Head, Midland Intl - Charlotte Douglas is the most popular route from Odessa to South Carolina.

  • Can I find deals for flights from Odessa to South Carolina that include hotel bookings?

    Yes. In addition to deals on Odessa to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Odessa to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Odessa to South Carolina.

  • Can I find deals for business class flights from Odessa to South Carolina?

    Yes. Cheapflights offers flight deals from Odessa to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for Odessa to South Carolina

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