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$204+ Cheap flights from Odessa, TX to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/13. Fares are subject to change and may not be available on all flights or dates of travel.
MAF — CHS
Jan 17 — Jan 241
Sat 1/17
Sat 1/24
1 adult, Economy
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Cheap flight deals from Odessa to South Carolina

Cheapest flights from Odessa to South Carolina
Explore the most affordable flight options available from Odessa to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

This American Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/306:00 amMAF - SAV
1 stop11h 47mAmerican Airlines
Sat 1/37:38 pmSAV - MAF
1 stop14h 03mAmerican Airlines
Deal found 12/15$729
This United Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/307:40 amMAF - SAV
1 stop6h 38mUnited Airlines
Sat 1/311:40 amSAV - MAF
1 stop12h 45mUnited Airlines
Deal found 12/15$817
This American Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1912:13 pmMAF - CLT
1 stop6h 08mAmerican Airlines
Fri 12/261:25 pmCLT - MAF
1 stop5h 09mAmerican Airlines
Deal found 12/17$887
This Southwest deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/193:45 pmMAF - CLT
2 stops6h 30mSouthwest
Fri 12/265:40 pmCLT - MAF
1 stop6h 25mSouthwest
Deal found 12/17$892

Find flight deals from Odessa to South Carolina

Keep the following information in mind while searching for Odessa to South Carolina flight deals. Data was last updated December 18, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$372
(Southwest)

One-way from

$204
(United Airlines)
Provider with most accurate pricing for Midland Intl-Myrtle Beach Intl flight deals.
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Provider most trusted by Cheapflights users for Midland Intl-Myrtle Beach Intl flights.
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From Odessa to South Carolina
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One-way flight from Odessa to South Carolina
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Odessa to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Odessa to South Carolina that are best for you.

Fly from

Odessa

Fly to

South Carolina

Route

Depart

Return

Price

MidlandCharlotte

MAF - CLT

MAFCLT

Midland Intl

Sat 1/31

5:50 am-2:45 pm

1 stop7h 55m

Charlotte Douglas

Fri 2/6

12:55 pm-9:20 pm

1 stop9h 25m

$372

MidlandCharlotte

MAF - CLT

MAFCLT

Midland Intl

Sat 1/31

4:55 pm-12:40 am

1 stop6h 45m

Charlotte Douglas

Fri 2/6

3:44 pm-8:49 pm

1 stop6h 05m

$372

MidlandCharlotte

MAF - CLT

MAFCLT

Midland Intl

Wed 2/18

7:00 am-9:09 pm

2 stops13h 09m

Charlotte Douglas

Sat 2/21

6:33 am-1:48 pm

1 stop8h 15m

$394

MidlandSavannah

MAF - SAV

MAFSAV

Midland Intl

Tue 1/13

7:00 am-1:17 pm

1 stop5h 17m

Savannah/Hilton Head

Wed 1/14

11:43 am-6:19 pm

1 stop7h 36m

$413

MidlandCharlotte

MAF - CLT

MAFCLT

Midland Intl

Sat 1/31

12:41 pm-9:10 pm

2 stops7h 29m

Charlotte Douglas

Sat 2/7

11:01 am-4:25 pm

1 stop6h 24m

$422

MidlandCharlotte

MAF - CLT

MAFCLT

Midland Intl

Sat 1/31

7:00 am-3:42 pm

1 stop7h 42m

Charlotte Douglas

Thu 2/5

6:45 am-1:54 pm

1 stop8h 09m

$424

MidlandSavannah

MAF - SAV

MAFSAV

Midland Intl

Tue 12/30

6:00 am-6:47 pm

1 stop11h 47m

Savannah/Hilton Head

Sat 1/3

7:38 pm-8:41 am

1 stop14h 03m

$729

MidlandSavannah

MAF - SAV

MAFSAV

Midland Intl

Tue 12/30

7:40 am-3:18 pm

1 stop6h 38m

Savannah/Hilton Head

Sat 1/3

11:40 am-11:25 pm

1 stop12h 45m

$817

MidlandCharlotte

MAF - CLT

MAFCLT

Midland Intl

Fri 2/13

2:56 pm-9:57 pm

1 stop6h 01m

$204

MidlandCharlotte

MAF - CLT

MAFCLT

Midland Intl

Fri 2/13

10:18 am-4:21 pm

1 stop5h 03m

$204

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/15

Showing 1-10 of 14 results
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Best time to book a flight from Odessa to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Odessa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Odessa to South Carolina
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Odessa to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Odessa to South Carolina?

    For as low as $413, Southwest can have you in South Carolina from Odessa in 5h 17m. There are 1227 mi between Odessa and South Carolina. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Odessa to South Carolina?

    While some choose either Midland Intl - Savannah/Hilton Head or Midland Intl - Myrtle Beach Intl, Midland Intl - Charlotte Douglas is the most popular route from Odessa to South Carolina.

  • Can I find deals for flights from Odessa to South Carolina that include hotel bookings?

    Yes. In addition to deals on Odessa to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Odessa to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Odessa to South Carolina.

  • Can I find deals for business class flights from Odessa to South Carolina?

    Yes. Cheapflights offers flight deals from Odessa to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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