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South Carolina

$168+ Cheap flights from Odessa, TX to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/7. Fares are subject to change and may not be available on all flights or dates of travel.
MAF — CHS
Apr 9 — Apr 161
Thu 4/9
Thu 4/16
1 adult, Economy
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Cheap flight deals from Odessa to South Carolina

Cheapest flights from Odessa to South Carolina
Explore the most affordable flight options available from Odessa to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 10, 2026.

This United Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/75:00 am
MAF
-
MYR
2 stops8h 17m
United Airlines
Wed 4/811:00 am
MYR
-
MAF
2 stops11h 39m
United Airlines
Deal found 3/5$361
This United Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/155:00 am
MAF
-
CLT
1 stop4h 51m
United Airlines
Sat 4/186:15 am
CLT
-
MAF
2 stops10h 47m
United Airlines
Deal found 3/5$365
This United Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/77:20 am
MAF
-
SAV
1 stop6h 44m
United Airlines
Tue 4/1411:31 am
SAV
-
MAF
2 stops11h 08m
United Airlines
Deal found 3/8$370
This Southwest deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/711:45 am
MAF
-
SAV
2 stops7h 15m
Southwest
Tue 4/142:20 pm
SAV
-
MAF
2 stops8h 55m
Southwest
Deal found 3/8$375
This Southwest deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/712:30 pm
MAF
-
CLT
2 stops8h 10m
Southwest
Tue 4/1411:20 am
CLT
-
MAF
1 stop7h 20m
Southwest
Deal found 3/8$376
This United Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/125:00 am
MAF
-
CLT
1 stop4h 51m
United Airlines
Wed 4/156:15 am
CLT
-
MAF
2 stops11h 11m
United Airlines
Deal found 3/5$386
This Southwest deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/1511:00 am
MAF
-
CLT
2 stops8h 45m
Southwest
Sat 4/186:10 am
CLT
-
MAF
2 stops10h 50m
Southwest
Deal found 3/5$391
This United Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/57:20 am
MAF
-
SAV
1 stop6h 54m
United Airlines
Wed 5/611:42 am
SAV
-
MAF
1 stop7h 30m
United Airlines
Deal found 3/5$415
This Southwest deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/125:25 am
MAF
-
CLT
2 stops8h 05m
Southwest
Wed 4/156:40 am
CLT
-
MAF
2 stops8h 25m
Southwest
Deal found 3/5$431
This United Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/95:00 am
MAF
-
CLT
2 stops10h 23m
United Airlines
Tue 5/1210:34 am
CLT
-
MAF
2 stops12h 41m
United Airlines
Deal found 3/5$436
This United Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/97:00 am
MAF
-
CLT
1 stop7h 15m
United Airlines
Wed 5/136:35 am
CLT
-
MAF
1 stop7h 57m
United Airlines
Deal found 3/8$437
This American Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/219:18 am
MAF
-
MYR
1 stop6h 15m
American Airlines
Wed 3/255:19 pm
MYR
-
MAF
1 stop7h 50m
American Airlines
Deal found 3/6$547

Find flight deals from Odessa to South Carolina

Keep the following information in mind while searching for Odessa to South Carolina flight deals. Data was last updated March 10, 2026.

Round-trip from

$361
(United Airlines)

One-way from

$168
(United Airlines)
From Odessa to South Carolina
Search Deals
One-way flight from Odessa to South Carolina
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Odessa to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 10, 2026.
Use the filters below to find and compare flights from Odessa to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

MidlandMyrtle Beach

MAF - MYR

MAFMYR

Midland Intl

Tue 4/7

5:00 am-2:17 pm

2 stops8h 17m

Myrtle Beach Intl

Wed 4/8

11:00 am-9:39 pm

2 stops11h 39m

$361

MidlandCharlotte

MAF - CLT

MAFCLT

Midland Intl

Tue 4/7

12:30 pm-9:40 pm

2 stops8h 10m

Charlotte Douglas

Tue 4/14

11:20 am-5:40 pm

1 stop7h 20m

$376

MidlandSavannah

MAF - SAV

MAFSAV

Midland Intl

Tue 5/5

7:20 am-3:14 pm

1 stop6h 54m

Savannah/Hilton Head

Wed 5/6

11:42 am-6:12 pm

1 stop7h 30m

$415

MidlandCharlotte

MAF - CLT

MAFCLT

Midland Intl

Sun 4/12

5:25 am-2:30 pm

2 stops8h 05m

Charlotte Douglas

Wed 4/15

6:40 am-2:05 pm

2 stops8h 25m

$431

MidlandCharlotte

MAF - CLT

MAFCLT

Midland Intl

Sat 5/9

2:13 pm-9:39 pm

1 stop6h 26m

Charlotte Douglas

Tue 5/12

10:34 am-10:15 pm

2 stops12h 41m

$431

MidlandCharlotte

MAF - CLT

MAFCLT

Midland Intl

Sat 5/9

7:00 am-3:15 pm

1 stop7h 15m

Charlotte Douglas

Wed 5/13

4:18 pm-10:15 pm

1 stop6h 57m

$436
Quickest round-trip

MidlandMyrtle Beach

MAF - MYR

MAFMYR

Midland Intl

Sat 3/21

9:18 am-4:33 pm

1 stop6h 15m

Myrtle Beach Intl

Wed 3/25

5:19 pm-12:09 am

1 stop7h 50m

$547

MidlandMyrtle Beach

MAF - MYR

MAFMYR

Midland Intl

Sat 3/21

5:00 am-5:12 pm

2 stops11h 12m

Myrtle Beach Intl

Wed 3/25

12:57 pm-11:15 pm

2 stops11h 18m

$558
Cheapest one-way
Quickest one-way

MidlandCharlotte

MAF - CLT

MAFCLT

Midland Intl

Tue 4/7

5:00 am-10:51 am

1 stop4h 51m

$168

MidlandCharlotte

MAF - CLT

MAFCLT

Midland Intl

Tue 4/7

12:30 pm-9:40 pm

2 stops8h 10m

$173

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/5

Showing 1-10 of 14 resultsSorted by cheapest first
1
2

Best time to book a flight from Odessa to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Odessa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Odessa to South Carolina
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Odessa to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Odessa to South Carolina?

    For as low as $376, United Airlines can have you in South Carolina from Odessa in 8h 10m. There are 1241 mi between Odessa and South Carolina. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Odessa to South Carolina?

    While some choose either Midland Intl - Savannah/Hilton Head or Midland Intl - Myrtle Beach Intl, Midland Intl - Charlotte Douglas is the most popular route from Odessa to South Carolina.

  • Can I find deals for flights from Odessa to South Carolina that include hotel bookings?

    Yes. In addition to deals on Odessa to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Odessa to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Odessa to South Carolina.

  • Can I find deals for business class flights from Odessa to South Carolina?

    Yes. Cheapflights offers flight deals from Odessa to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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