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South Carolina

$297+ Cheap flights from Odessa, TX to South Carolina

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/7. Fares are subject to change and may not be available on all flights or dates of travel.
MAF — CHS
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheap flight deals from Odessa to South Carolina

Keep the following information in mind while searching for Odessa to South Carolina flight deals. Data was last updated September 15, 2025.

Round-trip from

$297
(American Airlines)
From Odessa to South Carolina
Search Deals

Find flight deals from Odessa to South Carolina

Cheapest flights from Odessa to South Carolina
Explore the most affordable flight options available from Odessa to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/75:00 amMAF - CLT
1 stop6h 18mAmerican Airlines
Tue 10/76:31 pmCLT - MAF
1 stop5h 03mAmerican Airlines
Deal found 9/15$297
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/1412:33 pmMAF - CLT
2 stops8h 02mDelta
Tue 10/216:18 amCLT - MAF
2 stops11h 13mDelta
Deal found 9/14$307
This Southwest deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/275:40 amMAF - CLT
1 stop6h 55mSouthwest
Tue 9/304:50 pmCLT - MAF
1 stop5h 55mSouthwest
Deal found 9/13$311
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/412:33 pmMAF - CLT
2 stops10h 13mDelta
Tue 10/76:18 amCLT - MAF
2 stops11h 13mDelta
Deal found 9/15$314
This Southwest deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/145:45 amMAF - SAV
1 stop7h 35mSouthwest
Tue 12/167:50 amSAV - MAF
1 stop5h 40mSouthwest
Deal found 9/13$317
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/275:30 amMAF - CLT
2 stops6h 32mDelta
Tue 9/306:59 amCLT - MAF
2 stops10h 41mDelta
Deal found 9/13$321
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/142:25 pmMAF - CLT
1 stop6h 58mAmerican Airlines
Tue 10/212:56 pmCLT - MAF
1 stop6h 43mAmerican Airlines
Deal found 9/14$348
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1112:06 pmMAF - CLT
2 stops8h 35mUnited Airlines
Sun 10/127:00 amCLT - MAF
1 stop8h 02mUnited Airlines
Deal found 9/14$356
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/149:46 amMAF - CLT
2 stops10h 26mUnited Airlines
Tue 10/214:27 pmCLT - MAF
1 stop6h 31mUnited Airlines
Deal found 9/14$368
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/46:01 amMAF - CLT
1 stop6h 42mAmerican Airlines
Tue 10/72:56 pmCLT - MAF
1 stop6h 43mAmerican Airlines
Deal found 9/15$382
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/45:00 amMAF - CLT
2 stops11h 05mUnited Airlines
Tue 10/77:00 amCLT - MAF
1 stop8h 02mUnited Airlines
Deal found 9/15$474
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/2512:33 pmMAF - SAV
2 stops8h 12mDelta
Sun 9/285:20 amSAV - MAF
2 stops7h 33mDelta
Deal found 9/15$677

Cheapflights Fare Finder

 
Customize your flight search to find flights from Odessa to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Odessa to South Carolina that are best for you.

Fly from

Odessa

Fly to

South Carolina

Route

Depart

Return

Price

MidlandCharlotte

MAF - CLT

MAFCLT

Midland Intl

Tue 10/7

5:00 am-12:18 pm

1 stop6h 18m

Charlotte Douglas

Tue 10/7

6:31 pm-10:34 pm

1 stop5h 03m

$297

MidlandCharlotte

MAF - CLT

MAFCLT

Midland Intl

Tue 10/14

12:33 pm-9:35 pm

2 stops8h 02m

Charlotte Douglas

Tue 10/21

6:18 am-4:31 pm

2 stops11h 13m

$307

MidlandCharlotte

MAF - CLT

MAFCLT

Midland Intl

Sat 9/27

5:40 am-1:35 pm

1 stop6h 55m

Charlotte Douglas

Tue 9/30

4:50 pm-9:45 pm

1 stop5h 55m

$311

MidlandCharlotte

MAF - CLT

MAFCLT

Midland Intl

Sat 10/4

12:33 pm-11:46 pm

2 stops10h 13m

Charlotte Douglas

Tue 10/7

6:18 am-4:31 pm

2 stops11h 13m

$314

MidlandSavannah

MAF - SAV

MAFSAV

Midland Intl

Sun 12/14

10:00 am-6:55 pm

2 stops7h 55m

Savannah/Hilton Head

Tue 12/16

7:50 am-12:30 pm

1 stop5h 40m

$317

MidlandCharlotte

MAF - CLT

MAFCLT

Midland Intl

Sat 9/27

5:30 am-1:02 pm

2 stops6h 32m

Charlotte Douglas

Tue 9/30

6:59 am-4:40 pm

2 stops10h 41m

$321

MidlandCharlotte

MAF - CLT

MAFCLT

Midland Intl

Tue 10/14

2:25 pm-10:23 pm

1 stop6h 58m

Charlotte Douglas

Tue 10/21

2:56 pm-8:39 pm

1 stop6h 43m

$348

MidlandCharlotte

MAF - CLT

MAFCLT

Midland Intl

Tue 10/14

9:46 am-9:12 pm

2 stops10h 26m

Charlotte Douglas

Tue 10/21

4:27 pm-9:58 pm

1 stop6h 31m

$368

MidlandCharlotte

MAF - CLT

MAFCLT

Midland Intl

Sat 10/4

6:01 am-1:43 pm

1 stop6h 42m

Charlotte Douglas

Tue 10/7

2:56 pm-8:39 pm

1 stop6h 43m

$382

MidlandCharlotte

MAF - CLT

MAFCLT

Midland Intl

Sat 10/11

12:06 pm-9:41 pm

2 stops8h 35m

Charlotte Douglas

Sun 10/12

6:00 am-2:02 pm

2 stops9h 02m

$401

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Showing 1-10 of 15 results
1
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Best time to book a flight from Odessa to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Odessa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Odessa to South Carolina
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Odessa to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Odessa to South Carolina?

    For as low as $297, American Airlines can have you in South Carolina from Odessa in 6h 18m. There are 1241 mi between Odessa and South Carolina. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Odessa to South Carolina?

    While some choose either Midland Intl - Myrtle Beach Intl or Midland Intl - Savannah/Hilton Head, Midland Intl - Charlotte Douglas is the most popular route from Odessa to South Carolina.

  • Can I find deals for flights from Odessa to South Carolina that include hotel bookings?

    Yes. In addition to deals on Odessa to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Odessa to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Odessa to South Carolina.

  • Can I find deals for business class flights from Odessa to South Carolina?

    Yes. Cheapflights offers flight deals from Odessa to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Odessa to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Odessa to South Carolina (average of $217). Flying from Odessa to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Odessa to South Carolina

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