HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
South Carolina

$146+ Cheap flights from Medford (MFR) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/22. Fares are subject to change and may not be available on all flights or dates of travel.
MFR — CHS
Jan 17 — Jan 241
Sat 1/17
Sat 1/24
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Medford to South Carolina with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Medford to South Carolina

Cheapest flights from Medford to South Carolina
Explore the most affordable flight options available from Medford to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

This United Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/255:00 amMFR - GSP
1 stop7h 08mUnited Airlines
Sun 1/1110:00 amGSP - MFR
2 stops14h 02mUnited Airlines
Deal found 12/17$424
This United Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/266:00 amMFR - CAE
2 stops25h 05mUnited Airlines
Tue 1/62:37 pmCAE - MFR
2 stops33h 25mUnited Airlines
Deal found 12/17$799
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/236:34 pmMFR - CLT
2 stops25h 04mUnited Airlines
Tue 12/308:00 amCLT - MFR
1 stop16h 12mUnited Airlines
Deal found 12/16$859
This American Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/235:20 amMFR - CLT
1 stop8h 55mAmerican Airlines
Tue 12/301:10 pmCLT - MFR
1 stop10h 10mAmerican Airlines
Deal found 12/17$901
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/236:34 pmMFR - CLT
2 stops25h 04mUnited Airlines
Sat 12/276:22 amCLT - MFR
2 stops19h 35mUnited Airlines
Deal found 12/16$1,077
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/235:20 amMFR - CLT
1 stop8h 55mAmerican Airlines
Sat 12/277:30 amCLT - MFR
1 stop9h 29mAmerican Airlines
Deal found 12/16$1,173
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/195:00 amMFR - CLT
2 stops13h 20mUnited Airlines
Fri 12/266:20 amCLT - MFR
2 stops10h 05mUnited Airlines
Deal found 12/16$1,915
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/198:47 pmMFR - CLT
1 stop12h 12mAmerican Airlines
Fri 12/267:30 amCLT - MFR
1 stop15h 50mAmerican Airlines
Deal found 12/16$2,091

Find flight deals from Medford to South Carolina

Keep the following information in mind while searching for Medford to South Carolina flight deals. Data was last updated December 18, 2025.

Round-trip from

$329
(American Airlines)

One-way from

$146
(Kiwi.com)
From Medford to South Carolina
Search Deals
One-way flight from Medford to South Carolina
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Medford to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Medford to South Carolina that are best for you.

Fly from

Medford

Fly to

South Carolina

Route

Depart

Return

Price

MedfordCharlotte

MFR - CLT

MFRCLT

Medford

Sat 1/17

5:05 am-4:00 pm

1 stop7h 55m

Charlotte Douglas

Tue 1/20

5:10 pm-11:48 pm

1 stop9h 38m

$329

MedfordCharlotte

MFR - CLT

MFRCLT

Medford

Sun 1/11

6:00 pm-6:11 am

1 stop9h 11m

Charlotte Douglas

Sun 1/25

7:45 am-1:07 pm

1 stop8h 22m

$329

MedfordCharlotte

MFR - CLT

MFRCLT

Medford

Sun 1/11

5:20 pm-9:18 am

2 stops12h 58m

Charlotte Douglas

Sun 1/25

5:10 pm-11:48 pm

1 stop9h 38m

$359

MedfordCharlotte

MFR - CLT

MFRCLT

Medford

Thu 4/16

6:34 pm-9:55 am

2 stops12h 21m

Charlotte Douglas

Tue 4/21

6:00 am-1:01 pm

2 stops10h 01m

$391

MedfordGreenville

MFR - GSP

MFRGSP

Medford

Sat 1/10

5:00 am-3:20 pm

1 stop7h 20m

Greenville

Wed 1/14

10:51 am-9:02 pm

2 stops13h 11m

$410

MedfordGreenville

MFR - GSP

MFRGSP

Medford

Sat 2/14

5:02 am-7:24 pm

2 stops11h 22m

Greenville

Wed 2/18

10:00 am-9:18 pm

2 stops14h 18m

$415

MedfordColumbia

MFR - CAE

MFRCAE

Medford

Sat 1/24

6:00 am-11:44 pm

2 stops14h 44m

Columbia Metropolitan

Tue 1/27

8:00 am-5:54 pm

2 stops12h 54m

$427

MedfordColumbia

MFR - CAE

MFRCAE

Medford

Wed 1/28

5:00 am-9:21 pm

2 stops13h 21m

Columbia Metropolitan

Sat 1/31

10:10 am-9:02 pm

2 stops13h 52m

$427

MedfordCharlotte

MFR - CLT

MFRCLT

Medford

Sat 2/21

5:02 am-9:21 pm

2 stops13h 19m

Charlotte Douglas

Wed 2/25

4:25 pm-9:18 pm

1 stop7h 53m

$434

MedfordColumbia

MFR - CAE

MFRCAE

Medford

Tue 4/14

2:03 pm-9:59 am

3 stops16h 56m

Columbia Metropolitan

Fri 4/17

7:39 pm-5:50 pm

2 stops25h 11m

$548

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/17

Showing 1-10 of 40 results
1
2
3
4

Best time to book a flight from Medford to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Medford with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Medford to South Carolina

What is the cheapest time of day to fly from MFR to SC?

Find hourly flight availability from Medford to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 18, 2025.

When flying from Medford to South Carolina, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 77% versus a flight in the morning.

What is the cheapest day to fly from Medford to South Carolina?

Use this chart to determine the cheapest time to fly round-trip from Medford to South Carolina. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Medford to South Carolina flight should consider departing on Thursday evenings when fares are most often at their lowest. Sunday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated December 18, 2025.
Get a feel of what it's like to fly with Delta and United Airlines from Medford to South Carolina by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,005 reviews

Boarding

8.1

Crew

8.5

Entertainment

7.9

Comfort

7.9

Overall

7.9

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,005 reviews
Delta
7.9
Good
8,005 reviews

Boarding

8.1

Crew

8.5

Entertainment

7.9

Comfort

7.9

Overall

7.9

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,092 reviews
Delta
7.9
Good
8,005 reviews

Boarding

8.1

Crew

8.5

Entertainment

7.9

Comfort

7.9

Overall

7.9

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Medford to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Medford to South Carolina?

    Medford (MFR), located 3.0 mi from the city center, is the airport you fly out of when you book flights from Medford to South Carolina.

  • How long is the flight from Medford to South Carolina?

    Airlines like Delta, American Airlines, and United Airlines fly from Medford to South Carolina in about 7h 20m. The time it takes to get you to your destination can typically vary by up to 1h 51m. Airlines will cover a distance of 2230 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Medford to South Carolina one-way?

    To fly one-way, consider booking your trip with Delta, which is currently one of the cheapest options available, starting at $146. Alaska Airlines flights start at $147 while deals on United Airlines start at $160 one-way.

  • What are the most popular routes from Medford to South Carolina?

    The most popular flight routes from Medford to South Carolina are Medford - Charlotte Douglas, Medford - Columbia Metropolitan and Medford - Greenville.

  • Can I find deals for flights from Medford to South Carolina that include hotel bookings?

    Yes. In addition to deals on Medford to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Medford to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Medford to South Carolina.

  • Can I find deals for business class flights from Medford to South Carolina?

    Yes. Cheapflights offers flight deals from Medford to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Medford to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
Portland to Los Angeles flights
Portland to Las Vegas flights
Portland to John F Kennedy Intl flights
Portland to Sky Harbor Intl flights
Portland to Honolulu flights
Portland to Newark flights
Portland to Dallas/Fort Worth flights
Portland to Kahului flights
Portland to Minneapolis flights
Portland to Denver flights
Portland to LaGuardia flights
Portland to San Diego flights
Portland to Hobby flights
Portland to Ontario flights
Portland to Orlando flights
Portland to Palm Springs flights
Portland to San Francisco flights
Portland to Kailua-Kona flights
Portland to Santa Ana flights
Portland to Miami flights
Portland to George Bush Intcntl flights
Portland to O'Hare Intl flights
Portland to Atlanta flights
Boise to Las Vegas flights
Boise to Sky Harbor Intl flights
Portland to Boston flights
Boise to Seattle flights
Portland to Salt Lake City flights
Portland to Dulles Intl flights
Portland to New Orleans flights
Portland to Burbank flights
Portland to Lihue flights
Boise to Denver flights
Boise to Los Angeles flights
Portland to San Jose flights
Boise to Dallas/Fort Worth flights
Portland to Tampa flights
Portland to Fort Lauderdale flights
Portland to Tucson flights
Portland to Love Field flights
Portland to Nashville flights
Redmond to Seattle flights
Portland to Austin flights
Eugene to Las Vegas flights
Eugene to Sky Harbor Intl flights
Portland to Reagan-National flights
Boise to Orlando flights
Portland to Baltimore flights
Boise to O'Hare Intl flights
Portland to Detroit flights

Top 2 airlines flying from Medford to South Carolina

Discover the top 2 airlines that operate flights from Medford to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$234Average$523FlexibilityNo cancel feeOn-time69%
DeltaCheapest$261Average$369FlexibilityNo cancel feeOn-timeN/A

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.
Site
©2025 Cheapflights