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South Carolina

$160+ Cheap flights from Medford (MFR) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/19. Fares are subject to change and may not be available on all flights or dates of travel.
MFR — CHS
Apr 25 — May 21
Sat 4/25
Sat 5/2
1 adult, Economy
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Cheap flight deals from Medford to South Carolina

Cheapest flights from Medford to South Carolina
Explore the most affordable flight options available from Medford to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 26, 2026.

This United Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/125:00 am
MFR
-
GSP
1 stop7h 10m
United Airlines
Tue 9/224:15 pm
GSP
-
MFR
1 stop8h 01m
United Airlines
Deal found 3/24$389
This United Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/712:50 pm
MFR
-
CLT
1 stop7h 09m
United Airlines
Sat 4/118:06 am
CLT
-
MFR
1 stop8h 10m
United Airlines
Deal found 3/23$449
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/259:16 pm
MFR
-
CLT
1 stop31h 09m
Multiple Airlines
Sat 5/304:45 pm
CLT
-
MFR
2 stops30h 41m
Multiple Airlines
Deal found 3/25$479
This United Airlines deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/266:35 pm
MFR
-
CLT
2 stops12h 10m
United Airlines
Sat 5/304:08 pm
CLT
-
MFR
1 stop8h 09m
United Airlines
Deal found 3/21$493
This United Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/1812:50 pm
MFR
-
CLT
1 stop7h 09m
United Airlines
Wed 4/228:06 am
CLT
-
MFR
1 stop8h 10m
United Airlines
Deal found 3/24$499
This United Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/36:35 pm
MFR
-
GSP
2 stops12h 20m
United Airlines
Mon 6/84:15 pm
GSP
-
MFR
1 stop8h 01m
United Airlines
Deal found 3/24$511
This United Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/256:26 pm
MFR
-
CAE
2 stops12h 21m
United Airlines
Sat 8/2910:18 am
CAE
-
MFR
2 stops13h 58m
United Airlines
Deal found 3/24$513
This Delta deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/255:25 pm
MFR
-
CLT
2 stops12h 31m
Delta
Sat 5/301:05 pm
CLT
-
MFR
2 stops12h 04m
Delta
Deal found 3/25$523
This United Airlines deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/282:12 pm
MFR
-
CLT
3 stops15h 51m
United Airlines
Sat 5/26:15 am
CLT
-
MFR
2 stops14h 40m
United Airlines
Deal found 3/22$565
This Delta deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/45:25 pm
MFR
-
GSP
2 stops12h 39m
Delta
Tue 6/95:44 am
GSP
-
MFR
2 stops10h 17m
Delta
Deal found 3/24$576
This Delta deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/35:25 pm
MFR
-
GSP
2 stops12h 39m
Delta
Mon 6/85:44 am
GSP
-
MFR
2 stops10h 17m
Delta
Deal found 3/24$624
This Alaska Airlines deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/45:41 pm
MFR
-
GSP
2 stops14h 09m
Alaska Airlines
Tue 6/911:34 am
GSP
-
MFR
2 stops10h 05m
Alaska Airlines
Deal found 3/22$723

Find flight deals from Medford to South Carolina

Keep the following information in mind while searching for Medford to South Carolina flight deals. Data was last updated March 26, 2026.

Round-trip from

$389
(United Airlines)

One-way from

$160
(Delta)
From Medford to South Carolina
Search Deals
One-way flight from Medford to South Carolina
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Medford to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 26, 2026.
Use the filters below to find and compare flights from Medford to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

MedfordCharlotte

MFR - CLT

MFRCLT

Medford

Tue 4/7

12:50 pm-10:59 pm

1 stop7h 09m

Charlotte Douglas

Sat 4/11

8:06 am-1:16 pm

1 stop8h 10m

$449

MedfordCharlotte

MFR - CLT

MFRCLT

Medford

Tue 5/26

6:35 pm-9:45 am

2 stops12h 10m

Charlotte Douglas

Sat 5/30

4:08 pm-9:17 pm

1 stop8h 09m

$493

MedfordCharlotte

MFR - CLT

MFRCLT

Medford

Sat 4/18

12:50 pm-10:59 pm

1 stop7h 09m

Charlotte Douglas

Wed 4/22

8:06 am-1:16 pm

1 stop8h 10m

$499

MedfordCharlotte

MFR - CLT

MFRCLT

Medford

Tue 4/28

6:31 pm-1:21 pm

2 stops15h 50m

Charlotte Douglas

Sat 5/2

8:05 am-1:01 pm

1 stop7h 56m

$504

MedfordGreenville

MFR - GSP

MFRGSP

Medford

Wed 6/3

6:35 pm-9:55 am

2 stops12h 20m

Greenville

Mon 6/8

4:15 pm-9:16 pm

1 stop8h 01m

$511

MedfordCharlotte

MFR - CLT

MFRCLT

Medford

Mon 5/25

5:25 pm-8:56 am

2 stops12h 31m

Charlotte Douglas

Sat 5/30

1:05 pm-10:09 pm

2 stops12h 04m

$523

MedfordGreenville

MFR - GSP

MFRGSP

Medford

Thu 6/4

5:25 pm-9:04 am

2 stops12h 39m

Greenville

Tue 6/9

5:44 am-1:01 pm

2 stops10h 17m

$576

MedfordGreenville

MFR - GSP

MFRGSP

Medford

Thu 6/4

5:41 pm-10:50 am

2 stops14h 09m

Greenville

Tue 6/9

11:34 am-6:39 pm

2 stops10h 05m

$723

MedfordGreenville

MFR - GSP

MFRGSP

Medford

Thu 6/4

5:00 am-3:19 pm

1 stop7h 19m

Greenville

Tue 6/9

5:41 pm-12:04 pm

2 stops21h 23m

$754

MedfordColumbia

MFR - CAE

MFRCAE

Medford

Sun 4/5

5:14 am-6:02 pm

2 stops9h 48m

Columbia Metropolitan

Wed 4/8

2:43 pm-11:04 pm

2 stops11h 21m

$940

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/21

Showing 1-10 of 19 resultsSorted by cheapest first
1
2

Best time to book a flight from Medford to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Medford with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Medford to South Carolina

What is the cheapest time of day to fly from MFR to SC?

Find hourly flight availability from Medford to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 26, 2026.

When flying from Medford to South Carolina, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 64% versus a flight in the morning.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated March 26, 2026.
Get a feel of what it's like to fly with Delta and United Airlines from Medford to South Carolina by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,331 reviews

Crew

8.5

Comfort

7.9

Overall

7.9

Boarding

8.1

Entertainment

7.8

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,331 reviews
Delta
7.9
Good
8,331 reviews

Crew

8.5

Comfort

7.9

Overall

7.9

Boarding

8.1

Entertainment

7.8

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,484 reviews
Delta
7.9
Good
8,331 reviews

Crew

8.5

Comfort

7.9

Overall

7.9

Boarding

8.1

Entertainment

7.8

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Medford to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Medford to South Carolina?

    Medford (MFR), located 3.0 mi from the city center, is the airport you fly out of when you book flights from Medford to South Carolina.

  • How long is the flight from Medford to South Carolina?

    Airlines like United Airlines, Delta, and American Airlines fly from Medford to South Carolina in about 7h 09m. The time it takes to get you to your destination can typically vary by up to 5h 30m. Airlines will cover a distance of 2286 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Medford to South Carolina one-way?

    To fly one-way, consider booking your trip with Delta, which is currently one of the cheapest options available, starting at $124. Aeromexico flights start at $126 while deals on Alaska Airlines start at $150 one-way.

  • What are the most popular routes from Medford to South Carolina?

    The most popular flight routes from Medford to South Carolina are Medford - Charlotte Douglas, Medford - Greenville and Medford - Columbia Metropolitan.

  • Can I find deals for flights from Medford to South Carolina that include hotel bookings?

    Yes. In addition to deals on Medford to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Medford to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Medford to South Carolina.

  • Can I find deals for business class flights from Medford to South Carolina?

    Yes. Cheapflights offers flight deals from Medford to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for Medford to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Medford to South Carolina

Discover the top 2 airlines that operate flights from Medford to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 26, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$175Average$584FlexibilityNo cancel feeOn-time69%
DeltaCheapest$261Average$369FlexibilityNo cancel feeOn-timeN/A

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