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South Carolina

$339+ Cheap flights from Medford (MFR) to South Carolina

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/7. Fares are subject to change and may not be available on all flights or dates of travel.
MFR — CHS
Mar 11 — Mar 181
Wed 3/11
Wed 3/18
1 adult, Economy
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Cheap flight deals from Medford to South Carolina

Cheapest flights from Medford to South Carolina
Explore the most affordable flight options available from Medford to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 9, 2026.

This United Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/75:00 am
MFR
-
CLT
2 stops13h 15m
United Airlines
Tue 3/1011:07 am
CLT
-
MFR
2 stops13h 11m
United Airlines
Deal found 2/8$339
This United Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/231:10 pm
MFR
-
CLT
1 stop6h 57m
United Airlines
Sat 6/61:05 pm
CLT
-
MFR
2 stops12h 55m
United Airlines
Deal found 2/8$350
This United Airlines deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/1012:50 pm
MFR
-
CLT
1 stop7h 08m
United Airlines
Mon 4/138:06 am
CLT
-
MFR
1 stop8h 10m
United Airlines
Deal found 2/6$359
This United Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/166:31 pm
MFR
-
CLT
2 stops12h 22m
United Airlines
Mon 4/208:06 am
CLT
-
MFR
1 stop8h 10m
United Airlines
Deal found 2/9$392
This Delta deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/245:55 am
MFR
-
CLT
1 stop7h 00m
Delta
Sat 2/285:05 pm
CLT
-
MFR
1 stop8h 50m
Delta
Deal found 2/9$399
This American Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/75:13 am
MFR
-
CLT
1 stop7h 33m
American Airlines
Tue 3/104:25 pm
CLT
-
MFR
1 stop9h 48m
American Airlines
Deal found 2/8$402
This Delta deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/235:20 am
MFR
-
CLT
1 stop8h 09m
Delta
Sat 6/65:37 pm
CLT
-
MFR
1 stop7h 58m
Delta
Deal found 2/8$418
This United Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/247:00 am
MFR
-
CAE
2 stops13h 44m
United Airlines
Sat 2/289:00 am
CAE
-
MFR
2 stops16h 28m
United Airlines
Deal found 2/9$439
This United Airlines deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/185:02 am
MFR
-
GSP
1 stop7h 13m
United Airlines
Thu 2/266:12 am
GSP
-
MFR
2 stops14h 32m
United Airlines
Deal found 2/7$444
This Delta deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/285:20 am
MFR
-
CLT
1 stop8h 27m
Delta
Wed 6/175:25 pm
CLT
-
MFR
1 stop9h 16m
Delta
Deal found 2/8$449
This Alaska Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/286:00 am
MFR
-
CAE
2 stops9h 58m
Alaska Airlines
Sat 10/3112:45 pm
CAE
-
MFR
2 stops13h 10m
Alaska Airlines
Deal found 2/8$489
This United Airlines deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/217:00 am
MFR
-
GSP
2 stops13h 59m
United Airlines
Wed 2/254:16 pm
GSP
-
MFR
1 stop8h 02m
United Airlines
Deal found 2/7$494

Find flight deals from Medford to South Carolina

Keep the following information in mind while searching for Medford to South Carolina flight deals. Data was last updated February 9, 2026.

Round-trip from

$339
(United Airlines)
From Medford to South Carolina
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Medford to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 9, 2026.
Use the filters below to find and compare flights from Medford to South Carolina that are best for you.

Fly from

Medford

Fly to

South Carolina

Route

Depart

Return

Price

MedfordCharlotte

MFR - CLT

MFRCLT

Medford

Sat 3/7

5:00 am-9:15 pm

2 stops13h 15m

Charlotte Douglas

Tue 3/10

11:07 am-9:18 pm

2 stops13h 11m

$339

MedfordCharlotte

MFR - CLT

MFRCLT

Medford

Sat 5/23

1:10 pm-11:07 pm

1 stop6h 57m

Charlotte Douglas

Sat 6/6

1:05 pm-11:00 pm

2 stops12h 55m

$350

MedfordCharlotte

MFR - CLT

MFRCLT

Medford

Fri 4/10

12:50 pm-10:58 pm

1 stop7h 08m

Charlotte Douglas

Mon 4/13

8:06 am-1:16 pm

1 stop8h 10m

$359

MedfordCharlotte

MFR - CLT

MFRCLT

Medford

Wed 4/8

6:31 pm-9:03 am

2 stops11h 32m

Charlotte Douglas

Sat 4/11

8:06 am-1:16 pm

1 stop8h 10m

$385

MedfordCharlotte

MFR - CLT

MFRCLT

Medford

Tue 2/24

5:55 am-3:55 pm

1 stop7h 00m

Charlotte Douglas

Sat 2/28

5:05 pm-10:55 pm

1 stop8h 50m

$399

MedfordCharlotte

MFR - CLT

MFRCLT

Medford

Sat 5/23

5:20 am-4:29 pm

1 stop8h 09m

Charlotte Douglas

Sat 6/6

5:37 pm-10:35 pm

1 stop7h 58m

$418

MedfordColumbia

MFR - CAE

MFRCAE

Medford

Tue 2/24

7:00 am-11:44 pm

2 stops13h 44m

Columbia Metropolitan

Sat 2/28

9:00 am-10:28 pm

2 stops16h 28m

$439

MedfordCharlotte

MFR - CLT

MFRCLT

Medford

Thu 4/16

5:00 am-3:15 pm

1 stop7h 15m

Charlotte Douglas

Mon 4/20

8:06 am-1:16 pm

1 stop8h 10m

$451

MedfordGreenville

MFR - GSP

MFRGSP

Medford

Sat 2/21

7:00 am-11:59 pm

2 stops13h 59m

Greenville

Wed 2/25

4:16 pm-9:18 pm

1 stop8h 02m

$494

MedfordGreenville

MFR - GSP

MFRGSP

Medford

Sat 2/21

7:00 am-9:59 pm

2 stops11h 59m

Greenville

Tue 2/24

4:16 pm-9:18 pm

1 stop8h 02m

$494

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/6

Showing 1-10 of 24 results
1
2
3

Best time to book a flight from Medford to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Medford with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Medford to South Carolina

What is the cheapest time of day to fly from MFR to SC?

Find hourly flight availability from Medford to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 9, 2026.

When flying from Medford to South Carolina, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 64% versus a flight in the morning.

What is the cheapest day to fly from Medford to South Carolina?

Use this chart to determine the cheapest time to fly round-trip from Medford to South Carolina. Price data was last updated on March 30, 2025.

Travelers seeking maximum savings on their Medford to South Carolina flight should consider departing on Thursday evenings when fares are most often at their lowest. Sunday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated February 9, 2026.
Get a feel of what it's like to fly with Delta and United Airlines from Medford to South Carolina by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,178 reviews

Food

7.2

Overall

7.9

Boarding

8.1

Crew

8.5

Comfort

7.9

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,178 reviews
Delta
7.9
Good
8,178 reviews

Food

7.2

Overall

7.9

Boarding

8.1

Crew

8.5

Comfort

7.9

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,267 reviews
Delta
7.9
Good
8,178 reviews

Food

7.2

Overall

7.9

Boarding

8.1

Crew

8.5

Comfort

7.9

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Medford to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Medford to South Carolina?

    Medford (MFR), located 3.0 mi from the city center, is the airport you fly out of when you book flights from Medford to South Carolina.

  • How long is the flight from Medford to South Carolina?

    Airlines like United Airlines fly from Medford to South Carolina in about 13h 15m. The time it takes to get you to your destination can typically vary by up to . Airlines will cover a distance of 2286 mi.

  • What are the cheapest airlines to fly from Medford to South Carolina one-way?

    To fly one-way, consider booking your trip with Delta, which is currently one of the cheapest options available, starting at $124. Aeromexico flights start at $126 while deals on Alaska Airlines start at $150 one-way.

  • What are the most popular routes from Medford to South Carolina?

    The most popular flight routes from Medford to South Carolina are Medford - Charlotte Douglas, Medford - Greenville and Medford - Columbia Metropolitan.

  • Can I find deals for flights from Medford to South Carolina that include hotel bookings?

    Yes. In addition to deals on Medford to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Medford to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Medford to South Carolina.

  • Can I find deals for business class flights from Medford to South Carolina?

    Yes. Cheapflights offers flight deals from Medford to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for Medford to South Carolina

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Top 2 airlines flying from Medford to South Carolina

Discover the top 2 airlines that operate flights from Medford to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 9, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$175Average$523FlexibilityNo cancel feeOn-time69%
DeltaCheapest$261Average$369FlexibilityNo cancel feeOn-timeN/A

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