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South Carolina

$295+ Cheap flights from Medford (MFR) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/17. Fares are subject to change and may not be available on all flights or dates of travel.
MFR — CHS
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
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Cheap flight deals from Medford to South Carolina

Keep the following information in mind while searching for Medford to South Carolina flight deals. Data was last updated October 30, 2025.

Round-trip from

$309
(Delta)

One-way from

$295
(United Airlines)
From Medford to South Carolina
Search Deals
One-way flight from Medford to South Carolina
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Find flight deals from Medford to South Carolina

Cheapest flights from Medford to South Carolina
Explore the most affordable flight options available from Medford to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/75:00 amMFR - CLT
1 stop8h 24mDelta
Sat 12/135:34 pmCLT - MFR
1 stop8h 19mDelta
Deal found 10/29$309
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/611:40 amMFR - GSP
2 stops9h 01mDelta
Sat 12/135:35 amGSP - MFR
2 stops9h 26mDelta
Deal found 10/28$315
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/55:23 pmMFR - CLT
2 stops12h 55mDelta
Mon 12/85:11 pmCLT - MFR
2 stops9h 48mDelta
Deal found 10/28$349
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/65:00 amMFR - GSP
2 stops8h 53mUnited Airlines
Sat 12/134:23 pmGSP - MFR
1 stop8h 07mUnited Airlines
Deal found 10/28$619
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/15:00 amMFR - CAE
2 stops29h 47mUnited Airlines
Fri 12/55:24 pmCAE - MFR
2 stops22h 59mUnited Airlines
Deal found 10/30$738
This Alaska Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/2312:39 pmMFR - CLT
2 stops19h 26mAlaska Airlines
Tue 12/301:03 pmCLT - MFR
2 stops13h 56mAlaska Airlines
Deal found 10/29$817
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/235:00 amMFR - CLT
1 stop14h 38mUnited Airlines
Tue 12/306:20 amCLT - MFR
2 stops17h 52mUnited Airlines
Deal found 10/30$882
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/233:12 pmMFR - CLT
1 stop17h 47mAmerican Airlines
Tue 12/307:30 amCLT - MFR
1 stop15h 50mAmerican Airlines
Deal found 10/30$885
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/25:00 amMFR - CLT
1 stop7h 14mUnited Airlines
Tue 11/44:17 pmCLT - MFR
1 stop7h 58mUnited Airlines
Deal found 10/29$887
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/25:15 amMFR - CLT
1 stop8h 04mDelta
Tue 11/412:56 pmCLT - MFR
2 stops12h 54mDelta
Deal found 10/29$892
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/255:20 amMFR - CLT
1 stop8h 59mAmerican Airlines
Sat 11/294:39 pmCLT - MFR
1 stop9h 25mAmerican Airlines
Deal found 10/29$901

Cheapflights Fare Finder

 
Customize your flight search to find flights from Medford to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Medford to South Carolina that are best for you.

Fly from

Medford

Fly to

South Carolina

Route

Depart

Return

Price

MedfordCharlotte

MFR - CLT

MFRCLT

Medford

Fri 1/9

5:32 am-6:18 pm

1 stop9h 46m

Charlotte Douglas

Fri 1/16

2:32 pm-7:38 pm

1 stop8h 06m

$309

MedfordCharlotte

MFR - CLT

MFRCLT

Medford

Sun 12/7

5:00 am-4:24 pm

1 stop8h 24m

Charlotte Douglas

Sat 12/13

5:34 pm-10:53 pm

1 stop8h 19m

$309

MedfordCharlotte

MFR - CLT

MFRCLT

Medford

Fri 12/5

6:20 am-7:32 pm

1 stop10h 12m

Charlotte Douglas

Mon 12/8

2:32 pm-8:11 pm

1 stop8h 39m

$309

MedfordCharlotte

MFR - CLT

MFRCLT

Medford

Fri 12/5

5:00 am-4:24 pm

1 stop8h 24m

Charlotte Douglas

Mon 12/8

5:11 pm-11:59 pm

2 stops9h 48m

$314

MedfordGreenville

MFR - GSP

MFRGSP

Medford

Sat 12/6

11:40 am-11:41 pm

2 stops9h 01m

Greenville

Sat 12/13

5:35 am-12:01 pm

2 stops9h 26m

$315

MedfordColumbia

MFR - CAE

MFRCAE

Medford

Sat 3/7

6:05 am-8:28 am

2 stops23h 23m

Columbia Metropolitan

Tue 3/10

5:40 am-11:09 pm

2 stops20h 29m

$464

MedfordGreenville

MFR - GSP

MFRGSP

Medford

Tue 3/3

5:45 am-10:35 pm

2 stops13h 50m

Greenville

Sat 3/7

7:37 am-3:00 pm

2 stops10h 23m

$479

MedfordGreenville

MFR - GSP

MFRGSP

Medford

Tue 3/3

6:05 am-10:05 pm

2 stops13h 00m

Greenville

Sat 3/7

5:45 am-1:03 pm

2 stops10h 18m

$515

MedfordGreenville

MFR - GSP

MFRGSP

Medford

Tue 3/3

5:02 am-3:15 pm

1 stop7h 13m

Greenville

Sat 3/7

6:40 am-9:23 pm

2 stops17h 43m

$600

MedfordGreenville

MFR - GSP

MFRGSP

Medford

Sat 12/6

5:00 am-4:53 pm

2 stops8h 53m

Greenville

Sat 12/13

4:23 pm-9:30 pm

1 stop8h 07m

$619

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/29

Showing 1-10 of 19 results
1
2

Best time to book a flight from Medford to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Medford with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Medford to South Carolina

What is the cheapest month to book a flight from Medford to South Carolina?

Currently, July is the cheapest month in which you can book a flight from Medford to South Carolina (average of $175). Flying from Medford to South Carolina in December is currently the most expensive (average of $688). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MFR to SC?

Find hourly flight availability from Medford to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 30, 2025.

When flying from Medford to South Carolina, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 77% versus a flight in the morning.

What is the cheapest day to fly from Medford to South Carolina?

Use this chart to determine the cheapest time to fly round-trip from Medford to South Carolina. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Medford to South Carolina flight should consider departing on Thursday evenings when fares are most often at their lowest. Sunday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated October 30, 2025.
Get a feel of what it's like to fly with Alaska Airlines, Delta, and United Airlines from Medford to South Carolina by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
11,214 reviews

Overall

8.0

Boarding

8.1

Comfort

7.8

Crew

8.5

Food

7.1

Entertainment

7.0

Reviews

1 / 20
10.0
Excellent

Anonymous,Sep 2025

BOS - HNL

The flight was awesome but a little long. I would prefer a flight with a layover. The amount of space available was minimal and a little uncomfortable for that long of a flight.
Alaska Airlines
8.0
Very good
11,214 reviews
Alaska Airlines
8.0
Very good
11,214 reviews

Overall

8.0

Boarding

8.1

Comfort

7.8

Crew

8.5

Food

7.1

Entertainment

7.0

Reviews

1 / 20
10.0
Excellent

Anonymous,Sep 2025

BOS - HNL

The flight was awesome but a little long. I would prefer a flight with a layover. The amount of space available was minimal and a little uncomfortable for that long of a flight.
Delta
7.9
Good
7,993 reviews
Alaska Airlines
8.0
Very good
11,214 reviews

Overall

8.0

Boarding

8.1

Comfort

7.8

Crew

8.5

Food

7.1

Entertainment

7.0

Reviews

1 / 20
10.0
Excellent

Anonymous,Sep 2025

BOS - HNL

The flight was awesome but a little long. I would prefer a flight with a layover. The amount of space available was minimal and a little uncomfortable for that long of a flight.
United Airlines
7.4
Good
8,998 reviews
Alaska Airlines
8.0
Very good
11,214 reviews

Overall

8.0

Boarding

8.1

Comfort

7.8

Crew

8.5

Food

7.1

Entertainment

7.0

Reviews

1 / 20
10.0
Excellent

Anonymous,Sep 2025

BOS - HNL

The flight was awesome but a little long. I would prefer a flight with a layover. The amount of space available was minimal and a little uncomfortable for that long of a flight.

Related info for your journey

Find useful and relevant information for your journey from Medford to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Medford to South Carolina?

    Medford (MFR), located 3.0 mi from the city center, is the airport you fly out of when you book flights from Medford to South Carolina.

  • How long is the flight from Medford to South Carolina?

    Airlines like American Airlines, Delta, and Alaska Airlines fly from Medford to South Carolina in about 8h 24m. The time it takes to get you to your destination can typically vary by up to 5h 26m. Airlines will cover a distance of 2286 mi. This flight may include one or multiple stops.

  • What are the most popular routes from Medford to South Carolina?

    The most popular flight routes from Medford to South Carolina are Medford - Charlotte Douglas, Medford - Greenville and Medford - Columbia Metropolitan.

  • Can I find deals for flights from Medford to South Carolina that include hotel bookings?

    Yes. In addition to deals on Medford to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Medford to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Medford to South Carolina.

  • Can I find deals for business class flights from Medford to South Carolina?

    Yes. Cheapflights offers flight deals from Medford to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Medford to South Carolina?

    Currently, July is the cheapest month in which you can book a flight from Medford to South Carolina (average of $175). Flying from Medford to South Carolina in December is currently the most expensive (average of $688). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Medford to South Carolina

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Top 3 airlines flying from Medford to South Carolina

Discover the top 3 airlines that operate flights from Medford to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$234Average$531FlexibilityNo cancel feeOn-time69%
DeltaCheapest$274Average$369FlexibilityNo cancel feeOn-timeN/A
Alaska AirlinesCheapest$353Average$494FlexibilityNo cancel feeOn-time75%

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