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$378+ Cheap flights from La Crosse (LSE) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/9. Fares are subject to change and may not be available on all flights or dates of travel.
LSE — CHS
May 5 — May 121
Mon 5/5
Mon 5/12
1 adult, Economy
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Cheap flight deals from La Crosse to South Carolina

Keep the following information in mind while searching for La Crosse to South Carolina flight deals. Data was last updated April 30, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$410
(American Airlines)

One-way from

$378
(American Airlines)
Provider with most accurate pricing for La Crosse-Myrtle Beach Intl flight deals.
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Provider most trusted by Cheapflights users for La Crosse-Myrtle Beach Intl flights.
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From La Crosse to South Carolina
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One-way flight from La Crosse to South Carolina
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Find flight deals from La Crosse to South Carolina

Cheapest flights from La Crosse to South Carolina
Explore the most affordable flight options available from La Crosse to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 30, 2025.

This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/234:40 pmLSE - GSP
1 stop4h 06mAmerican Airlines
Sat 8/26:26 pmGSP - LSE
1 stop6h 05mAmerican Airlines
Deal found 4/28$410
This American Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/311:13 amLSE - CHS
1 stop7h 16mAmerican Airlines
Mon 7/77:48 pmCHS - LSE
1 stop4h 43mAmerican Airlines
Deal found 4/27$464
This American Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/2411:50 amLSE - SAV
2 stops11h 08mAmerican Airlines
Tue 5/275:00 amSAV - LSE
2 stops12h 05mAmerican Airlines
Deal found 4/27$542

Cheapflights Fare Finder

Customize your flight search to find flights from La Crosse to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 30, 2025.
Use the filters below to find and compare flights from La Crosse to South Carolina that are best for you.

Fly from

La Crosse

Fly to

South Carolina

Route

Depart

Return

Price

La CrosseGreenville

LSE - GSP

LSEGSP

La Crosse

Wed 7/23

4:40 pm-9:46 pm

1 stop4h 06m

Greenville

Sat 8/2

6:26 pm-11:31 pm

1 stop6h 05m

$410

La CrosseCharleston

LSE - CHS

LSECHS

La Crosse

Thu 7/3

11:13 am-7:29 pm

1 stop7h 16m

Charleston

Mon 7/7

7:48 pm-11:31 pm

1 stop4h 43m

$464

La CrosseSavannah

LSE - SAV

LSESAV

La Crosse

Sat 5/24

11:50 am-11:58 pm

2 stops11h 08m

Savannah/Hilton Head

Tue 5/27

5:00 am-4:05 pm

2 stops12h 05m

$542

La CrosseCharleston

LSE - CHS

LSECHS

La Crosse

Wed 7/9

11:29 am-7:17 pm

1 stop6h 48m

$378

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/27

Best time to book a flight from La Crosse to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from La Crosse with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from La Crosse to South Carolina

What is the cheapest month to book a flight from La Crosse to South Carolina?

Currently, August is the cheapest month in which you can book a flight from La Crosse to South Carolina (average of $217). Flying from La Crosse to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Rainfall in South Carolina by month

Plan your trip to South Carolina by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in South Carolina ranges from 3.0 - 6.5 inches per month. July is typically the wettest month, when rainfall can reach 6.5 in. November is typically the driest time to visit South Carolina when rainfall is around 3.0 in.

Temperature in South Carolina by month

Plan your trip to South Carolina by taking into account the average temperature totals by month.

If weather is an important factor for your trip to South Carolina, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 44.6 F).

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated April 30, 2025.
American Airlines
7.2
Good
10,000 reviews

Entertainment

6.9

Boarding

7.5

Overall

7.2

Crew

8.0

Food

6.5

Comfort

7.2

Reviews

1 / 20
10.0
Excellent

Anonymous,Apr 2025

MYR - CLT

This flight was impacted by a nearly 4, yes 4 hour delay. They replaced a 777 with another one and it had to be cleaned and catered before we could depart. Great crew did it without complaint.
American Airlines
7.2
Good
10,000 reviews
American Airlines
7.2
Good
10,000 reviews

Entertainment

6.9

Boarding

7.5

Overall

7.2

Crew

8.0

Food

6.5

Comfort

7.2

Reviews

1 / 20
10.0
Excellent

Anonymous,Apr 2025

MYR - CLT

This flight was impacted by a nearly 4, yes 4 hour delay. They replaced a 777 with another one and it had to be cleaned and catered before we could depart. Great crew did it without complaint.

Related info for your journey

Find useful and relevant information for your journey from La Crosse to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from La Crosse to South Carolina?

    Most people fly from La Crosse (LSE) if they book a flight from La Crosse to South Carolina. La Crosse is conveniently located just 5.4 mi from La Crosse’s city center.

  • What are the most popular routes from La Crosse to South Carolina?

    Most travelers choose La Crosse - Charleston, La Crosse - Savannah/Hilton Head or La Crosse - Greenville when deciding on the best route from La Crosse to South Carolina.

  • Can I find deals for flights from La Crosse to South Carolina that include hotel bookings?

    Yes. In addition to deals on La Crosse to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from La Crosse to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from La Crosse to South Carolina.

  • Can I find deals for business class flights from La Crosse to South Carolina?

    Yes. Cheapflights offers flight deals from La Crosse to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from La Crosse to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from La Crosse to South Carolina (average of $217). Flying from La Crosse to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for La Crosse to South Carolina

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Top airline flying from La Crosse to South Carolina

Discover the top airline that operate flights from La Crosse to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$569Average$674FlexibilityNo cancel feeOn-time71%

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