$253+ Cheap flights from La Crosse (LSE) to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/20. Fares are subject to change and may not be available on all flights or dates of travel.
LSE — CHS
Apr 10 — Apr 171
Round-trip
1 adult, Economy
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Find cheap flights from La Crosse to South Carolina with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from La Crosse to South CarolinaExplore the most affordable flight options available from La Crosse to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 11, 2026.
Explore the most affordable flight options available from La Crosse to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 11, 2026.
This American Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/211:34 am
LSE
- CLT
1 stop5h 47m
American Airlines
Thu 4/96:00 pm
CLT
- LSE
1 stop6h 54m
American Airlines
Deal found 3/11![American Airlines logo]()
$298
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/65:09 am
LSE
- CLT
1 stop4h 09m
American Airlines
Mon 4/136:00 pm
CLT
- LSE
1 stop6h 54m
American Airlines
Deal found 3/9![American Airlines logo]()
$349
This American Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/45:09 am
LSE
- CLT
1 stop7h 23m
American Airlines
Fri 4/102:04 pm
CLT
- LSE
1 stop5h 03m
American Airlines
Deal found 3/10![American Airlines logo]()
$368
This American Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/1410:05 am
LSE
- CLT
1 stop7h 36m
American Airlines
Sat 4/186:00 pm
CLT
- LSE
1 stop6h 54m
American Airlines
Deal found 3/11![American Airlines logo]()
$369
This American Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/1111:34 am
LSE
- CHS
1 stop4h 10m
American Airlines
Sat 3/146:08 pm
CHS
- LSE
1 stop6h 28m
American Airlines
Deal found 3/7![American Airlines logo]()
$418
This American Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/36:29 pm
LSE
- CLT
1 stop14h 49m
American Airlines
Tue 4/72:04 pm
CLT
- LSE
1 stop10h 50m
American Airlines
Deal found 3/8![American Airlines logo]()
$443
This American Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/215:09 am
LSE
- CHS
2 stops11h 56m
American Airlines
Sat 3/285:10 am
CHS
- LSE
2 stops6h 52m
American Airlines
Deal found 3/10![American Airlines logo]()
$445
This American Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/35:09 am
LSE
- CLT
1 stop4h 09m
American Airlines
Wed 4/83:24 pm
CLT
- LSE
2 stops9h 30m
American Airlines
Deal found 3/8![American Airlines logo]()
$459
This American Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/86:37 pm
LSE
- CHS
1 stop16h 12m
American Airlines
Sun 5/107:07 am
CHS
- LSE
1 stop17h 47m
American Airlines
Deal found 3/8![American Airlines logo]()
$473
This American Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/75:40 am
LSE
- CHS
1 stop16h 26m
American Airlines
Sun 5/107:07 am
CHS
- LSE
1 stop17h 47m
American Airlines
Deal found 3/8![American Airlines logo]()
$497
This American Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/196:00 am
LSE
- SAV
1 stop4h 37m
American Airlines
Sun 8/2312:23 pm
SAV
- LSE
1 stop6h 39m
American Airlines
Deal found 3/8![American Airlines logo]()
$497
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/211:34 am
LSE
- SAV
2 stops11h 23m
American Airlines
Mon 4/65:20 pm
SAV
- LSE
1 stop17h 15m
American Airlines
Deal found 3/9![American Airlines logo]()
$501
Best flights from La Crosse to South CarolinaDiscover carefully curated flight deals from La Crosse to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 11, 2026.
Discover carefully curated flight deals from La Crosse to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 11, 2026.
This American Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/211:34 am
LSE
- CLT
1 stop5h 47m
American Airlines
Thu 4/96:00 pm
CLT
- LSE
1 stop6h 54m
American Airlines
Deal found 3/11![American Airlines logo]()
$298
This United Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/269:42 am
LSE
- CHS
2 stops23h 20m
United Airlines
Sat 8/293:25 pm
CHS
- LSE
1 stop27h 45m
United Airlines
Deal found 3/7![United Airlines logo]()
$672
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/65:09 am
LSE
- CLT
1 stop4h 09m
American Airlines
Mon 4/136:00 pm
CLT
- LSE
1 stop6h 54m
American Airlines
Deal found 3/9![American Airlines logo]()
$349
This American Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/45:09 am
LSE
- CLT
1 stop7h 23m
American Airlines
Fri 4/102:04 pm
CLT
- LSE
1 stop5h 03m
American Airlines
Deal found 3/10![American Airlines logo]()
$368
This American Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/1410:05 am
LSE
- CLT
1 stop7h 36m
American Airlines
Sat 4/186:00 pm
CLT
- LSE
1 stop6h 54m
American Airlines
Deal found 3/11![American Airlines logo]()
$369
This American Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/36:29 pm
LSE
- CLT
1 stop14h 49m
American Airlines
Tue 4/72:04 pm
CLT
- LSE
1 stop10h 50m
American Airlines
Deal found 3/8![American Airlines logo]()
$443
This American Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/35:09 am
LSE
- CLT
1 stop4h 09m
American Airlines
Wed 4/83:24 pm
CLT
- LSE
2 stops9h 30m
American Airlines
Deal found 3/8![American Airlines logo]()
$459
This United Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/81:49 pm
LSE
- CHS
2 stops28h 10m
United Airlines
Sun 5/106:00 am
CHS
- LSE
2 stops19h 17m
United Airlines
Deal found 3/8![United Airlines logo]()
$697
This American Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1910:53 am
LSE
- SAV
2 stops7h 10m
American Airlines
Sun 8/2312:23 pm
SAV
- LSE
1 stop6h 39m
American Airlines
Deal found 3/8![American Airlines logo]()
$503
This American Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/206:00 am
LSE
- SAV
1 stop4h 37m
American Airlines
Sun 8/2312:23 pm
SAV
- LSE
1 stop6h 39m
American Airlines
Deal found 3/7![American Airlines logo]()
$524
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/211:34 am
LSE
- SAV
1 stop10h 14m
American Airlines
Mon 4/65:20 pm
SAV
- LSE
1 stop17h 15m
American Airlines
Deal found 3/9![American Airlines logo]()
$530
This American Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/2811:52 am
LSE
- SAV
2 stops11h 07m
American Airlines
Mon 6/11:15 pm
SAV
- LSE
1 stop11h 51m
American Airlines
Deal found 3/11![American Airlines logo]()
$531
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/111:34 am
LSE
- SAV
2 stops11h 23m
American Airlines
Mon 4/65:20 pm
SAV
- LSE
1 stop17h 15m
American Airlines
Deal found 3/9![American Airlines logo]()
$533
This American Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/256:29 pm
LSE
- CLT
1 stop14h 49m
American Airlines
Sun 3/2911:00 pm
CLT
- LSE
1 stop13h 01m
American Airlines
Deal found 3/7![American Airlines logo]()
$608
This American Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/249:48 am
LSE
- CHS
1 stop5h 56m
American Airlines
Fri 3/273:48 pm
CHS
- LSE
2 stops8h 48m
American Airlines
Deal found 3/10![American Airlines logo]()
$642
This American Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/3011:34 am
LSE
- CHS
2 stops10h 27m
American Airlines
Sat 4/45:20 pm
CHS
- LSE
2 stops7h 16m
American Airlines
Deal found 3/7![American Airlines logo]()
$694
Last-minute flights from La Crosse to South CarolinaDiscover last-minute flight deals from La Crosse to South Carolina. Data last updated March 11, 2026 and is based on user searches.
Discover last-minute flight deals from La Crosse to South Carolina. Data last updated March 11, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/1111:34 am
LSE
- CHS
1 stop4h 10m
American Airlines
Sat 3/146:08 pm
CHS
- LSE
1 stop6h 28m
American Airlines
Deal found 3/7![American Airlines logo]()
$418
This American Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/215:09 am
LSE
- CHS
2 stops11h 56m
American Airlines
Sat 3/285:10 am
CHS
- LSE
2 stops6h 52m
American Airlines
Deal found 3/10![American Airlines logo]()
$445
This American Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/249:48 am
LSE
- CHS
1 stop5h 56m
American Airlines
Fri 3/275:23 pm
CHS
- LSE
1 stop7h 13m
American Airlines
Deal found 3/10![American Airlines logo]()
$636
This American Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/256:29 pm
LSE
- CLT
1 stop14h 49m
American Airlines
Sun 3/2911:00 pm
CLT
- LSE
1 stop13h 01m
American Airlines
Deal found 3/7![American Airlines logo]()
$608
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/111:34 am
LSE
- SAV
1 stop10h 14m
American Airlines
Mon 4/65:20 pm
SAV
- LSE
1 stop17h 15m
American Airlines
Deal found 3/9![American Airlines logo]()
$527
This American Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/211:34 am
LSE
- CLT
1 stop5h 47m
American Airlines
Thu 4/96:00 pm
CLT
- LSE
1 stop6h 54m
American Airlines
Deal found 3/11![American Airlines logo]()
$298
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/211:34 am
LSE
- SAV
2 stops11h 23m
American Airlines
Mon 4/65:20 pm
SAV
- LSE
1 stop17h 15m
American Airlines
Deal found 3/9![American Airlines logo]()
$501
This American Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/36:29 pm
LSE
- CLT
1 stop14h 49m
American Airlines
Tue 4/72:04 pm
CLT
- LSE
1 stop10h 50m
American Airlines
Deal found 3/8![American Airlines logo]()
$443
This American Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/35:09 am
LSE
- CLT
1 stop4h 09m
American Airlines
Wed 4/83:24 pm
CLT
- LSE
2 stops9h 30m
American Airlines
Deal found 3/8![American Airlines logo]()
$459
This American Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/45:09 am
LSE
- CLT
1 stop7h 23m
American Airlines
Fri 4/102:04 pm
CLT
- LSE
1 stop5h 03m
American Airlines
Deal found 3/10![American Airlines logo]()
$368
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/65:09 am
LSE
- CLT
1 stop4h 09m
American Airlines
Mon 4/136:00 pm
CLT
- LSE
1 stop6h 54m
American Airlines
Deal found 3/9![American Airlines logo]()
$349
This American Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/1410:05 am
LSE
- CLT
1 stop7h 36m
American Airlines
Sat 4/186:00 pm
CLT
- LSE
1 stop6h 54m
American Airlines
Deal found 3/11![American Airlines logo]()
$369
One-way flights from La Crosse to South CarolinaSearch for one-way flight options from La Crosse to South Carolina. Find affordable one-way fares based on user searches. Data last updated March 11, 2026.
Search for one-way flight options from La Crosse to South Carolina. Find affordable one-way fares based on user searches. Data last updated March 11, 2026.
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/205:34 pm
LSE
- CLT
1 stop5h 25m
American Airlines
Deal found 3/9![American Airlines logo]()
$253
This American Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/1210:05 am
LSE
- CHS
1 stop6h 57m
American Airlines
Deal found 3/7![American Airlines logo]()
$275
This American Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/106:37 pm
LSE
- CHS
1 stop16h 12m
American Airlines
Deal found 3/7![American Airlines logo]()
$278
This American Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/810:05 am
LSE
- CHS
2 stops11h 36m
American Airlines
Deal found 3/7![American Airlines logo]()
$281
This American Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/3011:34 am
LSE
- CHS
2 stops8h 12m
American Airlines
Deal found 3/7![American Airlines logo]()
$294
This American Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/1110:05 am
LSE
- CHS
1 stop12h 03m
American Airlines
Deal found 3/7![American Airlines logo]()
$339
This American Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/285:09 am
LSE
- CHS
2 stops11h 56m
American Airlines
Deal found 3/7![American Airlines logo]()
$359
This United Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/201:53 pm
LSE
- CLT
2 stops20h 09m
United Airlines
Deal found 3/9![United Airlines logo]()
$364
This American Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/95:40 am
LSE
- CHS
1 stop16h 28m
American Airlines
Deal found 3/7![American Airlines logo]()
$374
Find flight deals from La Crosse to South Carolina
Keep the following information in mind while searching for La Crosse to South Carolina flight deals. Data was last updated March 11, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $298 (American Airlines) |
One-way from | $253 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from La Crosse to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 11, 2026.
Use the filters below to find and compare flights from La Crosse to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
La CrosseCharlotte
LSE - CLT
LSECLT
La Crosse
Thu 4/2
11:34 am-6:21 pm
1 stop5h 47m
Charlotte Douglas
Thu 4/9
6:00 pm-11:54 pm
1 stop6h 54m
$298
Quickest round-trip
La CrosseCharlotte
LSE - CLT
LSECLT
La Crosse
Mon 4/6
5:09 am-10:18 am
1 stop4h 09m
Charlotte Douglas
Mon 4/13
6:00 pm-11:54 pm
1 stop6h 54m
$349
La CrosseCharlotte
LSE - CLT
LSECLT
La Crosse
Sat 4/4
5:09 am-1:32 pm
1 stop7h 23m
Charlotte Douglas
Fri 4/10
2:04 pm-6:07 pm
1 stop5h 03m
$368
La CrosseCharlotte
LSE - CLT
LSECLT
La Crosse
Tue 4/14
10:05 am-6:41 pm
1 stop7h 36m
Charlotte Douglas
Sat 4/18
6:00 pm-11:54 pm
1 stop6h 54m
$369
La CrosseCharlotte
LSE - CLT
LSECLT
La Crosse
Fri 4/3
6:29 pm-10:18 am
1 stop14h 49m
Charlotte Douglas
Tue 4/7
2:04 pm-11:54 pm
1 stop10h 50m
$443
La CrosseCharlotte
LSE - CLT
LSECLT
La Crosse
Fri 4/3
5:09 am-10:18 am
1 stop4h 09m
Charlotte Douglas
Wed 4/8
3:24 pm-11:54 pm
2 stops9h 30m
$459
La CrosseSavannah
LSE - SAV
LSESAV
La Crosse
Wed 8/19
10:53 am-7:03 pm
2 stops7h 10m
Savannah/Hilton Head
Sun 8/23
12:23 pm-6:02 pm
1 stop6h 39m
$503
La CrosseSavannah
LSE - SAV
LSESAV
La Crosse
Thu 8/20
6:00 am-11:37 am
1 stop4h 37m
Savannah/Hilton Head
Sun 8/23
12:23 pm-6:02 pm
1 stop6h 39m
$524
La CrosseSavannah
LSE - SAV
LSESAV
La Crosse
Thu 4/2
11:34 am-10:48 pm
1 stop10h 14m
Savannah/Hilton Head
Mon 4/6
5:20 pm-9:35 am
1 stop17h 15m
$530
La CrosseSavannah
LSE - SAV
LSESAV
La Crosse
Thu 5/28
11:52 am-11:59 pm
2 stops11h 07m
Savannah/Hilton Head
Mon 6/1
1:15 pm-12:06 am
1 stop11h 51m
$531
Showing 1-10 of 26 resultsSorted by cheapest first
Best time to book a flight from La Crosse to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from La Crosse with our price prediction graph.
LSE-CLT
LSE-CHS
LSE-SAV
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from La Crosse to South Carolina
LSE-USSC
LSE-CLT
LSE-CHS
LSE-SAV
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated March 11, 2026.
Read reviews from past customers who have flown American Airlines from La Crosse to South Carolina. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Boarding
7.5
Crew
7.9
Food
6.4
Overall
7.1
Entertainment
6.9
Comfort
7.2
Reviews
1 / 20
2.0
MediocreAnonymous,Mar 2026
MIA - SFO
Boarding
7.5
Crew
7.9
Food
6.4
Overall
7.1
Entertainment
6.9
Comfort
7.2
Reviews
1 / 20
2.0
MediocreAnonymous,Mar 2026
MIA - SFO
Related info for your journey
Find useful and relevant information for your journey from La Crosse to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for La Crosse to South Carolina
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La Crosse and South Carolina flights
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La Crosse to South Carolina flights
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Top airline flying from La Crosse to South Carolina
Discover the top airline that operate flights from La Crosse to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 11, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$514 | Average$689 | FlexibilityNo cancel fee | On-time71% |