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$451+ Cheap flights from La Crosse (LSE) to South Carolina

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/18. Fares are subject to change and may not be available on all flights or dates of travel.
LSE — CHS
Nov 27 — Dec 41
Thu 11/27
Thu 12/4
1 adult, Economy
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Cheap flight deals from La Crosse to South Carolina

Keep the following information in mind while searching for La Crosse to South Carolina flight deals. Data was last updated October 28, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$451
(American Airlines)
Provider with most accurate pricing for La Crosse-Myrtle Beach Intl flight deals.
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Provider most trusted by Cheapflights users for La Crosse-Myrtle Beach Intl flights.
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From La Crosse to South Carolina
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Find flight deals from La Crosse to South Carolina

Cheapest flights from La Crosse to South Carolina
Explore the most affordable flight options available from La Crosse to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 28, 2025.

This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1810:09 amLSE - CLT
1 stop5h 47mAmerican Airlines
Tue 1/64:42 pmCLT - LSE
1 stop6h 34mAmerican Airlines
Deal found 10/28$451
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/186:00 amLSE - GSP
1 stop4h 01mAmerican Airlines
Mon 1/58:07 pmGSP - LSE
1 stop4h 31mAmerican Airlines
Deal found 10/26$464
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/316:00 amLSE - CHS
1 stop6h 12mAmerican Airlines
Sun 11/26:44 pmCHS - LSE
1 stop6h 05mAmerican Airlines
Deal found 10/27$479
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1810:09 amLSE - CLT
1 stop5h 47mAmerican Airlines
Mon 1/52:52 pmCLT - LSE
1 stop5h 44mAmerican Airlines
Deal found 10/28$484
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/16:15 pmLSE - CHS
1 stop5h 00mAmerican Airlines
Mon 11/36:40 pmCHS - LSE
1 stop6h 09mAmerican Airlines
Deal found 10/27$489
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/110:54 amLSE - CHS
2 stops10h 02mAmerican Airlines
Sun 11/26:44 pmCHS - LSE
1 stop6h 05mAmerican Airlines
Deal found 10/27$495
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/316:00 amLSE - CHS
1 stop6h 12mAmerican Airlines
Sat 11/11:42 pmCHS - LSE
1 stop5h 03mAmerican Airlines
Deal found 10/27$510
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/296:00 amLSE - CHS
1 stop6h 12mAmerican Airlines
Sat 11/11:42 pmCHS - LSE
1 stop5h 03mAmerican Airlines
Deal found 10/27$520
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/296:00 amLSE - CHS
1 stop6h 12mAmerican Airlines
Sun 11/26:44 pmCHS - LSE
1 stop6h 05mAmerican Airlines
Deal found 10/27$544
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/306:15 pmLSE - CHS
1 stop5h 00mAmerican Airlines
Fri 11/76:40 pmCHS - LSE
1 stop6h 09mAmerican Airlines
Deal found 10/27$568
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/216:00 amLSE - GSP
1 stop3h 58mAmerican Airlines
Sat 11/228:14 pmGSP - LSE
1 stop4h 35mAmerican Airlines
Deal found 10/26$647
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/266:00 amLSE - CHS
1 stop4h 55mAmerican Airlines
Thu 1/14:49 pmCHS - LSE
1 stop7h 49mAmerican Airlines
Deal found 10/27$726

Cheapflights Fare Finder

 
Customize your flight search to find flights from La Crosse to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 28, 2025.
Use the filters below to find and compare flights from La Crosse to South Carolina that are best for you.

Fly from

La Crosse

Fly to

South Carolina

Route

Depart

Return

Price

La CrosseCharlotte

LSE - CLT

LSECLT

La Crosse

Thu 12/18

10:09 am-4:56 pm

1 stop5h 47m

Charlotte Douglas

Tue 1/6

4:42 pm-10:16 pm

1 stop6h 34m

$451

La CrosseGreenville

LSE - GSP

LSEGSP

La Crosse

Thu 12/18

6:00 am-11:01 am

1 stop4h 01m

Greenville

Mon 1/5

8:07 pm-11:38 pm

1 stop4h 31m

$464

La CrosseCharlotte

LSE - CLT

LSECLT

La Crosse

Thu 12/18

6:00 am-1:32 pm

1 stop6h 32m

Charlotte Douglas

Mon 1/5

2:52 pm-7:36 pm

1 stop5h 44m

$484

La CrosseCharleston

LSE - CHS

LSECHS

La Crosse

Sat 4/11

1:03 pm-9:28 pm

2 stops7h 25m

Charleston

Wed 4/15

11:08 am-3:58 pm

1 stop5h 50m

$513

La CrosseGreenville

LSE - GSP

LSEGSP

La Crosse

Fri 11/21

6:00 am-10:58 am

1 stop3h 58m

Greenville

Sat 11/22

8:14 pm-11:49 pm

1 stop4h 35m

$647

La CrosseCharleston

LSE - CHS

LSECHS

La Crosse

Fri 12/26

6:00 am-11:55 am

1 stop4h 55m

Charleston

Thu 1/1

4:49 pm-11:38 pm

1 stop7h 49m

$726

La CrosseCharleston

LSE - CHS

LSECHS

La Crosse

Fri 12/26

6:00 am-11:55 am

1 stop4h 55m

Charleston

Fri 1/2

2:33 pm-11:38 pm

2 stops10h 05m

$732

La CrosseGreenville

LSE - GSP

LSEGSP

La Crosse

Tue 4/14

4:43 pm-9:28 pm

1 stop3h 45m

Greenville

Wed 4/15

7:59 am-10:56 am

1 stop3h 57m

$776

La CrosseSavannah

LSE - SAV

LSESAV

La Crosse

Mon 11/24

9:50 am-7:44 pm

2 stops8h 54m

Savannah/Hilton Head

Sun 11/30

5:06 pm-8:52 pm

1 stop4h 46m

$886

La CrosseCharlotte

LSE - CLT

LSECLT

La Crosse

Thu 12/18

6:00 am-1:32 pm

1 stop6h 32m

$470

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/26

Best time to book a flight from La Crosse to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from La Crosse with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from La Crosse to South Carolina
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from La Crosse to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from La Crosse to South Carolina?

    Most people fly from La Crosse (LSE) if they book a flight from La Crosse to South Carolina. La Crosse is conveniently located just 5.4 mi from La Crosse’s city center.

  • How long is the flight from La Crosse to South Carolina?

    A quick flight from La Crosse to South Carolina can take about 5h 47m. American Airlines provides one of the quickest options available for as low as $451. There are 810 mi between La Crosse and South Carolina.

  • What are the most popular routes from La Crosse to South Carolina?

    Most travelers choose La Crosse - Charleston, La Crosse - Greenville or La Crosse - Charlotte Douglas when deciding on the best route from La Crosse to South Carolina.

  • Can I find deals for flights from La Crosse to South Carolina that include hotel bookings?

    Yes. In addition to deals on La Crosse to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from La Crosse to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from La Crosse to South Carolina.

  • Can I find deals for business class flights from La Crosse to South Carolina?

    Yes. Cheapflights offers flight deals from La Crosse to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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