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South Carolina

$408+ Cheap flights from La Crosse (LSE) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/31. Fares are subject to change and may not be available on all flights or dates of travel.
LSE — CHS
feb. 26 — mar. 51
jue. 2/26
jue. 3/5
1 adult, Economy
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Cheap flight deals from La Crosse to South Carolina

Cheapest flights from La Crosse to South Carolina
Explore the most affordable flight options available from La Crosse to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on enero 27, 2026.

This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 3/1111:34 am
LSE
-
CHS
1 stop4h 10m
American Airlines
sáb. 3/147:10 am
CHS
-
LSE
1 stop4h 52m
American Airlines
Deal found 1/27$430
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 3/32:36 pm
LSE
-
SAV
1 stop7h 12m
American Airlines
mar. 3/105:20 pm
SAV
-
LSE
1 stop7h 16m
American Airlines
Deal found 1/26$430
This American Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 4/65:09 am
LSE
-
CLT
1 stop4h 09m
American Airlines
sáb. 4/112:13 pm
CLT
-
LSE
1 stop4h 49m
American Airlines
Deal found 1/25$471
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/111:21 am
LSE
-
CLT
2 stops6h 46m
American Airlines
mar. 10/66:00 pm
CLT
-
LSE
1 stop6h 19m
American Airlines
Deal found 1/27$477
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 2/105:08 pm
LSE
-
GSP
1 stop5h 51m
American Airlines
sáb. 2/147:29 am
GSP
-
LSE
1 stop4h 26m
American Airlines
Deal found 1/26$490
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 2/145:20 am
LSE
-
CLT
1 stop4h 47m
American Airlines
sáb. 2/216:26 pm
CLT
-
LSE
1 stop6h 10m
American Airlines
Deal found 1/26$492
This American Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 3/1411:35 am
LSE
-
CHS
2 stops10h 26m
American Airlines
jue. 3/195:25 pm
CHS
-
LSE
1 stop7h 11m
American Airlines
Deal found 1/25$493
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 2/106:00 am
LSE
-
CLT
2 stops8h 18m
American Airlines
sáb. 2/143:54 pm
CLT
-
LSE
2 stops8h 42m
American Airlines
Deal found 1/26$521
This American Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 3/1411:35 am
LSE
-
SAV
2 stops9h 09m
American Airlines
jue. 3/1911:59 am
SAV
-
LSE
1 stop7h 00m
American Airlines
Deal found 1/25$522
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 2/106:00 am
LSE
-
CHS
2 stops12h 05m
American Airlines
sáb. 2/147:10 am
CHS
-
LSE
1 stop4h 45m
American Airlines
Deal found 1/26$525
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 3/305:09 am
LSE
-
CHS
1 stop5h 25m
American Airlines
sáb. 4/46:08 pm
CHS
-
LSE
1 stop6h 28m
American Airlines
Deal found 1/26$566
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 2/1211:31 am
LSE
-
CHS
1 stop4h 13m
American Airlines
dom. 2/155:15 pm
CHS
-
LSE
2 stops7h 21m
American Airlines
Deal found 1/27$574

Find flight deals from La Crosse to South Carolina

Keep the following information in mind while searching for La Crosse to South Carolina flight deals. Data was last updated enero 27, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$430
(American Airlines)

One-way from

$408
(American Airlines)
Provider with most accurate pricing for La Crosse-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for La Crosse-Myrtle Beach Intl flights.
Search Deals
From La Crosse to South Carolina
Search Deals
One-way flight from La Crosse to South Carolina
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Cheapflights Fare Finder

 
Customize your flight search to find flights from La Crosse to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated enero 27, 2026.
Use the filters below to find and compare flights from La Crosse to South Carolina that are best for you.

Fly from

La Crosse

Fly to

South Carolina

Route

Depart

Return

Price

La CrosseSavannah

LSE - SAV

LSESAV

La Crosse

mar. 3/3

2:36 pm-10:48 pm

1 stop7h 12m

Savannah/Hilton Head

mar. 3/10

5:20 pm-11:36 pm

1 stop7h 16m

$430

La CrosseCharleston

LSE - CHS

LSECHS

La Crosse

mié. 3/11

11:34 am-8:46 pm

2 stops8h 12m

Charleston

sáb. 3/14

7:10 am-11:02 am

1 stop4h 52m

$436

La CrosseCharlotte

LSE - CLT

LSECLT

La Crosse

lun. 4/6

5:09 am-10:18 am

1 stop4h 09m

Charlotte Douglas

sáb. 4/11

2:13 pm-6:02 pm

1 stop4h 49m

$471

La CrosseGreenville

LSE - GSP

LSEGSP

La Crosse

mar. 2/10

5:08 pm-11:59 pm

1 stop5h 51m

Greenville

sáb. 2/14

7:29 am-10:55 am

1 stop4h 26m

$490

La CrosseCharlotte

LSE - CLT

LSECLT

La Crosse

mar. 2/10

5:08 pm-10:57 pm

1 stop4h 49m

Charlotte Douglas

sáb. 2/14

6:26 pm-11:36 pm

1 stop6h 10m

$492

La CrosseCharlotte

LSE - CLT

LSECLT

La Crosse

sáb. 2/14

5:20 am-11:07 am

1 stop4h 47m

Charlotte Douglas

sáb. 2/21

6:26 pm-11:36 pm

1 stop6h 10m

$492

La CrosseCharleston

LSE - CHS

LSECHS

La Crosse

sáb. 3/14

11:35 am-11:01 pm

2 stops10h 26m

Charleston

jue. 3/19

5:25 pm-11:36 pm

1 stop7h 11m

$493

La CrosseSavannah

LSE - SAV

LSESAV

La Crosse

sáb. 3/14

11:35 am-9:44 pm

2 stops9h 09m

Savannah/Hilton Head

jue. 3/19

11:59 am-5:59 pm

1 stop7h 00m

$522

La CrosseCharleston

LSE - CHS

LSECHS

La Crosse

jue. 2/12

11:31 am-4:44 pm

1 stop4h 13m

Charleston

dom. 2/15

5:15 pm-11:36 pm

2 stops7h 21m

$574

La CrosseCharleston

LSE - CHS

LSECHS

La Crosse

jue. 2/12

11:31 am-4:44 pm

1 stop4h 13m

Charleston

lun. 2/16

7:10 am-11:01 am

1 stop4h 51m

$588

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/26

Showing 1-10 of 20 results
1
2

Best time to book a flight from La Crosse to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from La Crosse with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from La Crosse to South Carolina
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from La Crosse to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from La Crosse to South Carolina?

    Most people fly from La Crosse (LSE) if they book a flight from La Crosse to South Carolina. La Crosse is conveniently located just 5.4 mi from La Crosse’s city center.

  • How long is the flight from La Crosse to South Carolina?

    A quick flight from La Crosse to South Carolina can take about 7h 12m. American Airlines provides one of the quickest options available for as low as $430. There are 977 mi between La Crosse and South Carolina.

  • What are the most popular routes from La Crosse to South Carolina?

    Most travelers choose La Crosse - Charleston, La Crosse - Savannah/Hilton Head or La Crosse - Charlotte Douglas when deciding on the best route from La Crosse to South Carolina.

  • Can I find deals for flights from La Crosse to South Carolina that include hotel bookings?

    Yes. In addition to deals on La Crosse to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from La Crosse to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from La Crosse to South Carolina.

  • Can I find deals for business class flights from La Crosse to South Carolina?

    Yes. Cheapflights offers flight deals from La Crosse to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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