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$433+ Cheap flights from La Crosse (LSE) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/13. Fares are subject to change and may not be available on all flights or dates of travel.
LSE — CHS
Jan 11 — Jan 181
Sun 1/11
Sun 1/18
1 adult, Economy
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Cheap flight deals from La Crosse to South Carolina

Cheapest flights from La Crosse to South Carolina
Explore the most affordable flight options available from La Crosse to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

This American Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/186:00 amLSE - CLT
1 stop6h 32mAmerican Airlines
Tue 1/612:10 pmCLT - LSE
1 stop5h 06mAmerican Airlines
Deal found 12/11$550
This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/2610:09 amLSE - CLT
1 stop5h 47mAmerican Airlines
Tue 12/302:52 pmCLT - LSE
1 stop5h 44mAmerican Airlines
Deal found 12/10$618

Find flight deals from La Crosse to South Carolina

Keep the following information in mind while searching for La Crosse to South Carolina flight deals. Data was last updated December 12, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$541
(American Airlines)

One-way from

$433
(American Airlines)
Provider with most accurate pricing for La Crosse-Myrtle Beach Intl flight deals.
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Provider most trusted by Cheapflights users for La Crosse-Myrtle Beach Intl flights.
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From La Crosse to South Carolina
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One-way flight from La Crosse to South Carolina
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Cheapflights Fare Finder

 
Customize your flight search to find flights from La Crosse to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
Use the filters below to find and compare flights from La Crosse to South Carolina that are best for you.

Fly from

La Crosse

Fly to

South Carolina

Route

Depart

Return

Price

La CrosseCharlotte

LSE - CLT

LSECLT

La Crosse

Fri 2/13

10:03 am-7:07 pm

2 stops8h 04m

Charlotte Douglas

Sat 2/28

6:25 pm-11:36 pm

1 stop6h 11m

$457

La CrosseCharleston

LSE - CHS

LSECHS

La Crosse

Thu 2/26

10:03 am-4:27 pm

1 stop5h 24m

Charleston

Mon 3/2

4:57 pm-11:36 pm

1 stop7h 39m

$541

La CrosseCharlotte

LSE - CLT

LSECLT

La Crosse

Thu 12/18

10:09 am-4:56 pm

1 stop5h 47m

Charlotte Douglas

Tue 1/6

12:10 pm-4:16 pm

1 stop5h 06m

$550

La CrosseSavannah

LSE - SAV

LSESAV

La Crosse

Sat 1/24

6:00 am-12:50 pm

1 stop5h 50m

Savannah/Hilton Head

Wed 1/28

3:45 pm-10:16 pm

1 stop7h 31m

$550

La CrosseSavannah

LSE - SAV

LSESAV

La Crosse

Thu 1/8

11:37 am-10:43 pm

2 stops10h 06m

Savannah/Hilton Head

Thu 1/15

3:45 pm-10:16 pm

1 stop7h 31m

$606

La CrosseCharlotte

LSE - CLT

LSECLT

La Crosse

Fri 12/26

10:09 am-4:56 pm

1 stop5h 47m

Charlotte Douglas

Tue 12/30

2:52 pm-7:36 pm

1 stop5h 44m

$618

La CrosseSavannah

LSE - SAV

LSESAV

La Crosse

Sat 1/17

6:00 am-4:35 pm

2 stops9h 35m

Savannah/Hilton Head

Tue 1/20

3:45 pm-10:16 pm

1 stop7h 31m

$636

La CrosseCharlotte

LSE - CLT

LSECLT

La Crosse

Wed 1/14

5:08 pm-10:54 pm

1 stop4h 46m

Charlotte Douglas

Fri 1/16

10:18 pm-4:16 pm

1 stop18h 58m

$743

La CrosseCharlotte

LSE - CLT

LSECLT

La Crosse

Tue 1/13

6:00 am-1:10 pm

1 stop6h 10m

Charlotte Douglas

Fri 1/16

6:37 pm-4:16 pm

1 stop22h 39m

$743

La CrosseCharlotte

LSE - CLT

LSECLT

La Crosse

Tue 1/13

5:08 pm-10:54 pm

1 stop4h 46m

$433

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/10

Showing 1-10 of 11 results
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Best time to book a flight from La Crosse to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from La Crosse with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from La Crosse to South Carolina
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from La Crosse to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from La Crosse to South Carolina?

    Most people fly from La Crosse (LSE) if they book a flight from La Crosse to South Carolina. La Crosse is conveniently located just 5.4 mi from La Crosse’s city center.

  • How long is the flight from La Crosse to South Carolina?

    A quick flight from La Crosse to South Carolina can take about 8h 04m. American Airlines provides one of the quickest options available for as low as $457. There are 810 mi between La Crosse and South Carolina.

  • What are the most popular routes from La Crosse to South Carolina?

    Most travelers choose La Crosse - Charlotte Douglas, La Crosse - Charleston or La Crosse - Savannah/Hilton Head when deciding on the best route from La Crosse to South Carolina.

  • Can I find deals for flights from La Crosse to South Carolina that include hotel bookings?

    Yes. In addition to deals on La Crosse to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from La Crosse to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from La Crosse to South Carolina.

  • Can I find deals for business class flights from La Crosse to South Carolina?

    Yes. Cheapflights offers flight deals from La Crosse to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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