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$378+ Cheap flights from La Crosse (LSE) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/7. Fares are subject to change and may not be available on all flights or dates of travel.
LSE — CHS
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheap flight deals from La Crosse to South Carolina

Keep the following information in mind while searching for La Crosse to South Carolina flight deals. Data was last updated September 11, 2025.

Round-trip from

$449
(American Airlines)

One-way from

$378
(American Airlines)
From La Crosse to South Carolina
Search Deals
One-way flight from La Crosse to South Carolina
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Find flight deals from La Crosse to South Carolina

Cheapest flights from La Crosse to South Carolina
Explore the most affordable flight options available from La Crosse to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/146:15 pmLSE - CLT
1 stop15h 03mAmerican Airlines
Fri 11/1410:18 pmCLT - LSE
1 stop12h 11mAmerican Airlines
Deal found 9/10$449
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/2010:09 amLSE - CHS
1 stop6h 35mAmerican Airlines
Thu 9/256:17 pmCHS - LSE
1 stop6h 00mAmerican Airlines
Deal found 9/11$469
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/710:54 amLSE - CLT
1 stop4h 06mAmerican Airlines
Sun 11/26:00 pmCLT - LSE
1 stop6h 49mAmerican Airlines
Deal found 9/10$475
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/156:00 amLSE - CLT
1 stop4h 22mAmerican Airlines
Tue 11/1811:18 amCLT - LSE
1 stop5h 52mAmerican Airlines
Deal found 9/9$488
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/106:15 pmLSE - CLT
1 stop4h 44mAmerican Airlines
Sun 10/128:15 pmCLT - LSE
1 stop4h 11mAmerican Airlines
Deal found 9/10$501
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/46:00 amLSE - CLT
1 stop6h 04mAmerican Airlines
Wed 10/81:01 pmCLT - LSE
1 stop5h 44mAmerican Airlines
Deal found 9/10$528
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/56:00 amLSE - SAV
2 stops10h 44mAmerican Airlines
Sat 11/89:00 amSAV - LSE
2 stops9h 32mAmerican Airlines
Deal found 9/10$561
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/266:30 pmLSE - GSP
1 stop15h 26mAmerican Airlines
Tue 9/3010:25 amGSP - LSE
2 stops8h 26mAmerican Airlines
Deal found 9/10$701
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/76:00 amLSE - GSP
1 stop3h 52mAmerican Airlines
Fri 10/108:04 pmGSP - LSE
1 stop15h 20mAmerican Airlines
Deal found 9/10$758

Cheapflights Fare Finder

 
Customize your flight search to find flights from La Crosse to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from La Crosse to South Carolina that are best for you.

Fly from

La Crosse

Fly to

South Carolina

Route

Depart

Return

Price

La CrosseCharlotte

LSE - CLT

LSECLT

La Crosse

Tue 10/14

6:15 pm-10:18 am

1 stop15h 03m

Charlotte Douglas

Fri 11/14

10:18 pm-9:29 am

1 stop12h 11m

$449

La CrosseCharlotte

LSE - CLT

LSECLT

La Crosse

Tue 10/7

10:54 am-4:00 pm

1 stop4h 06m

Charlotte Douglas

Sun 11/2

6:00 pm-11:49 pm

1 stop6h 49m

$475

La CrosseCharlotte

LSE - CLT

LSECLT

La Crosse

Sat 11/15

6:00 am-11:22 am

1 stop4h 22m

Charlotte Douglas

Tue 11/18

11:18 am-4:10 pm

1 stop5h 52m

$488

La CrosseCharlotte

LSE - CLT

LSECLT

La Crosse

Fri 10/10

6:15 pm-11:59 pm

1 stop4h 44m

Charlotte Douglas

Sun 10/12

8:15 pm-11:26 pm

1 stop4h 11m

$501

La CrosseCharlotte

LSE - CLT

LSECLT

La Crosse

Sat 10/4

6:00 am-1:35 pm

2 stops6h 35m

Charlotte Douglas

Wed 10/8

1:01 pm-5:45 pm

1 stop5h 44m

$534

La CrosseSavannah

LSE - SAV

LSESAV

La Crosse

Wed 11/5

6:00 am-5:44 pm

2 stops10h 44m

Savannah/Hilton Head

Sat 11/8

9:00 am-5:32 pm

2 stops9h 32m

$561

La CrosseGreenville

LSE - GSP

LSEGSP

La Crosse

Fri 9/26

6:30 pm-10:56 am

1 stop15h 26m

Greenville

Tue 9/30

10:25 am-5:51 pm

2 stops8h 26m

$701

La CrosseGreenville

LSE - GSP

LSEGSP

La Crosse

Tue 10/7

6:00 am-10:52 am

1 stop3h 52m

Greenville

Fri 10/10

8:04 pm-10:24 am

1 stop15h 20m

$758

La CrosseGreenville

LSE - GSP

LSEGSP

La Crosse

Tue 10/7

6:00 am-10:52 am

1 stop3h 52m

$378

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Best time to book a flight from La Crosse to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from La Crosse with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from La Crosse to South Carolina
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from La Crosse to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from La Crosse to South Carolina?

    Most people fly from La Crosse (LSE) if they book a flight from La Crosse to South Carolina. La Crosse is conveniently located just 5.4 mi from La Crosse’s city center.

  • How long is the flight from La Crosse to South Carolina?

    A quick flight from La Crosse to South Carolina can take about 15h 03m. American Airlines provides one of the quickest options available for as low as $449. There are 810 mi between La Crosse and South Carolina.

  • What are the most popular routes from La Crosse to South Carolina?

    Most travelers choose La Crosse - Charlotte Douglas, La Crosse - Savannah/Hilton Head or La Crosse - Greenville when deciding on the best route from La Crosse to South Carolina.

  • Can I find deals for flights from La Crosse to South Carolina that include hotel bookings?

    Yes. In addition to deals on La Crosse to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from La Crosse to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from La Crosse to South Carolina.

  • Can I find deals for business class flights from La Crosse to South Carolina?

    Yes. Cheapflights offers flight deals from La Crosse to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from La Crosse to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from La Crosse to South Carolina (average of $217). Flying from La Crosse to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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