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$282+ Cheap flights from Italy to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/3. Fares are subject to change and may not be available on all flights or dates of travel.
NAP — CHS
ene. 1 — ene. 81
jue. 1/1
jue. 1/8
1 adult, Economy
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Cheap flight deals from Italy to South Carolina

Cheapest flights from Italy to South Carolina
Explore the most affordable flight options available from Italy to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on diciembre 2, 2025.

This American Airlines deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/1111:00 amFCO - CLT
1 stop14h 45mAmerican Airlines
dom. 1/116:30 pmCLT - FCO
1 stop21h 25mAmerican Airlines
Deal found 11/30$684
This United Airlines deal was found by Cheapflights users on 11/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 12/71:05 pmMXP - CHS
2 stops40h 37mUnited Airlines
dom. 12/146:00 amCHS - MXP
1 stop19h 30mUnited Airlines
Deal found 11/29$702
This KLM deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/1612:00 pmMXP - CLT
1 stop16h 46mMultiple Airlines
dom. 1/116:53 pmCLT - MXP
2 stops14h 02mMultiple Airlines
Deal found 11/30$710
This Delta deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/1611:05 amMXP - CLT
1 stop15h 14mDelta
dom. 1/115:00 pmCLT - MXP
2 stops15h 55mDelta
Deal found 12/2$711
This KLM deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/1610:55 amLIN - CLT
2 stops17h 00mMultiple Airlines
dom. 1/111:13 pmCLT - LIN
2 stops13h 32mMultiple Airlines
Deal found 11/30$712
This Air France deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/1611:35 amMXP - CLT
2 stops17h 11mAir France
dom. 1/116:53 pmCLT - MXP
2 stops14h 02mAir France
Deal found 11/30$713
This Iberia deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Iberia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/117:30 amFCO - CLT
1 stop14h 55mIberia
dom. 1/114:37 pmCLT - FCO
2 stops16h 53mIberia
Deal found 11/30$713
This KLM deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/1612:00 pmMXP - CLT
1 stop27h 18mKLM
dom. 1/119:29 amCLT - MXP
1 stop17h 36mKLM
Deal found 12/2$715
This United Airlines deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/1111:00 amFCO - CLT
2 stops16h 59mUnited Airlines
dom. 1/116:30 pmCLT - FCO
2 stops13h 30mUnited Airlines
Deal found 12/2$719
This American Airlines deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/57:25 amLIN - CHS
2 stops17h 04mAmerican Airlines
mar. 12/95:38 pmCHS - LIN
2 stops14h 52mAmerican Airlines
Deal found 12/2$784
This British Airways deal was found by Cheapflights users on 11/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure British Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 12/710:40 amLIN - CHS
2 stops17h 20mBritish Airways
dom. 12/146:31 pmCHS - LIN
2 stops13h 59mBritish Airways
Deal found 11/29$785
This Finnair deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Finnair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/510:25 amMXP - CHS
1 stop16h 18mMultiple Airlines
mar. 12/911:56 amCHS - MXP
1 stop14h 09mMultiple Airlines
Deal found 12/2$785

Find flight deals from Italy to South Carolina

Keep the following information in mind while searching for Italy to South Carolina flight deals. Data was last updated diciembre 2, 2025.

Round-trip from

$550
(Trip.com)

One-way from

$282
(Kiwi.com)
From Italy to South Carolina
Search Deals
One-way flight from Italy to South Carolina
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Italy to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated diciembre 2, 2025.
Use the filters below to find and compare flights from Italy to South Carolina that are best for you.

Fly from

Italy

Fly to

South Carolina

Route

Depart

Return

Price

RomeCharlotte

FCO - CLT

FCOCLT

Rome Fiumicino

dom. 1/18

11:25 am-11:59 pm

2 stops18h 34m

Charlotte Douglas

vie. 1/23

9:06 am-2:00 pm

2 stops22h 54m

$550

MilanCharlotte

MXP - CLT

MXPCLT

Milan Malpensa

lun. 1/12

9:15 am-11:59 pm

2 stops20h 44m

Charlotte Douglas

dom. 1/18

9:06 am-10:25 am

2 stops19h 19m

$578

MilanCharlotte

MXP - CLT

MXPCLT

Milan Malpensa

mié. 1/14

9:15 am-11:59 pm

2 stops20h 44m

Charlotte Douglas

mié. 1/21

6:00 am-10:25 am

3 stops22h 25m

$605

VeniceCharlotte

VCE - CLT

VCECLT

Venice Marco Polo

lun. 1/12

6:55 am-4:05 pm

1 stop15h 10m

Charlotte Douglas

dom. 1/18

8:25 pm-4:55 pm

1 stop14h 30m

$608

VeniceCharlotte

VCE - CLT

VCECLT

Venice Marco Polo

lun. 1/19

6:55 am-7:05 pm

1 stop18h 10m

Charlotte Douglas

dom. 1/25

8:25 pm-4:55 pm

1 stop14h 30m

$611

MilanCharleston

MXP - CHS

MXPCHS

Milan Malpensa

vie. 1/16

9:45 am-5:59 pm

1 stop14h 14m

Charleston

vie. 1/23

2:58 pm-10:45 am

2 stops13h 47m

$614

VeniceCharlotte

VCE - CLT

VCECLT

Venice Marco Polo

lun. 1/12

6:30 am-6:59 pm

2 stops18h 29m

Charlotte Douglas

dom. 1/18

6:50 pm-4:15 pm

1 stop15h 25m

$618

VeniceCharlotte

VCE - CLT

VCECLT

Venice Marco Polo

jue. 4/16

6:50 pm-1:10 pm

1 stop24h 20m

Charlotte Douglas

jue. 5/7

11:45 pm-6:40 pm

1 stop12h 55m

$622

MilanCharleston

MXP - CHS

MXPCHS

Milan Malpensa

vie. 1/16

9:10 am-7:04 pm

2 stops15h 54m

Charleston

vie. 1/23

4:55 pm-7:30 am

2 stops32h 35m

$630

MilanCharleston

MXP - CHS

MXPCHS

Milan Malpensa

vie. 3/6

9:10 am-7:00 pm

2 stops15h 50m

Charleston

mié. 3/11

8:15 am-7:30 am

2 stops18h 15m

$630

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/2

Showing 1-10 of 60 results
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Best time to book a flight from Italy to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Italy with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Italy to South Carolina

What is the cheapest time of day to fly from IT to SC?

Find hourly flight availability from Italy to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated diciembre 2, 2025.

It’s optimal to fly from Italy to South Carolina in the afternoon. By choosing this option you can save up to 15% on the cost of your flight, compared to a flight in the evening.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated diciembre 2, 2025.
Read reviews from past customers who have flown Lufthansa from Italy to South Carolina. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Lufthansa
6.8
Okay
7,603 reviews

Entertainment

6.4

Boarding

7.0

Crew

7.6

Comfort

6.8

Food

6.3

Overall

6.8

Reviews

1 / 20
8.0
Excellent

Anonymous,Jan 2025

FRA - TPA

I had ordered a gluten-free meal through you I double triple checked that through you got screamed at by one of your representatives. She yelled at me and said that she had ordered the mail, she had chosen my seat, and made sure that all my baggage is were paid for. That was a lie. My experience with discover airlines in and of itself was GOOD but your representative was out of line did not do anything that she screamed at me and told me she did and I literally had to call the airlines myself to get my seat selected to double check on my gluten-free meal which still was not on board and to pay for my bags which I thought that I paid for all of them until I got to the airport and I still had to pay for my check back. So cheap flights I will never use you again.
Lufthansa
6.8
Okay
7,603 reviews
Lufthansa
6.8
Okay
7,603 reviews

Entertainment

6.4

Boarding

7.0

Crew

7.6

Comfort

6.8

Food

6.3

Overall

6.8

Reviews

1 / 20
8.0
Excellent

Anonymous,Jan 2025

FRA - TPA

I had ordered a gluten-free meal through you I double triple checked that through you got screamed at by one of your representatives. She yelled at me and said that she had ordered the mail, she had chosen my seat, and made sure that all my baggage is were paid for. That was a lie. My experience with discover airlines in and of itself was GOOD but your representative was out of line did not do anything that she screamed at me and told me she did and I literally had to call the airlines myself to get my seat selected to double check on my gluten-free meal which still was not on board and to pay for my bags which I thought that I paid for all of them until I got to the airport and I still had to pay for my check back. So cheap flights I will never use you again.

Related info for your journey

Find useful and relevant information for your journey from Italy to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Italy to South Carolina?

    A quick flight from Italy to South Carolina can take about 14h 14m. Lufthansa provides one of the quickest options available for as low as $614. The distance from Italy to South Carolina is about 4582 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Italy to South Carolina one-way?

    To fly one-way, consider booking your trip with Delta, which is currently one of the cheapest options available, starting at $182. American Airlines flights start at $265 while deals on United Airlines start at $269 one-way.

  • Can I find deals for flights from Italy to South Carolina that include hotel bookings?

    Yes. In addition to deals on Italy to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Italy to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Italy to South Carolina.

  • Can I find deals for business class flights from Italy to South Carolina?

    Yes. Cheapflights offers flight deals from Italy to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

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