How long is the flight from Italy to South Carolina?

A quick flight from Italy to South Carolina can take about 16h 17m. American Airlines provides one of the quickest options available for as low as $667. The distance from Italy to South Carolina is about 4519 mi. This flight may include one or multiple stops.

In terms of precipitation, rainfall in South Carolina ranges from 3.0 - 6.5 inches per month. July is typically the wettest month, when rainfall can reach 6.5 in. November is typically the driest time to visit South Carolina when rainfall is around 3.0 in.

If weather is an important factor for your trip to South Carolina, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 44.6 F).

Can I find deals for flights from Italy to South Carolina that include hotel bookings?

Yes. In addition to deals on Italy to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Italy to South Carolina?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Italy to South Carolina.

Can I find deals for business class flights from Italy to South Carolina?

Yes. Cheapflights offers flight deals from Italy to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$313+ Cheap Flights from Italy to South Carolina

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1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

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Find flight deals from Italy to South Carolina

Cheapest flights from Italy to South Carolina
Explore the most affordable flight options available from Italy to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 16, 2025.

Thu 11/139:15 amMXP - CLT

2 stops19h 53mMultiple Airlines

Wed 11/195:45 amCLT - MXP

2 stops22h 40mMultiple Airlines

Deal found 10/16

$522

Fri 11/217:10 pmFCO - CLT

1 stop31h 15mMultiple Airlines

Thu 12/49:00 amCLT - FCO

2 stops23h 30mMultiple Airlines

Deal found 10/16

$558

Thu 11/207:00 amFCO - CLT

2 stops31h 49mMultiple Airlines

Wed 12/310:17 amCLT - FCO

1 stop22h 13mMultiple Airlines

Deal found 10/15

$571

Thu 11/136:30 amLIN - CLT

2 stops22h 38mMultiple Airlines

Wed 11/195:45 amCLT - LIN

2 stops22h 25mMultiple Airlines

Deal found 10/16

$605

Mon 11/108:00 pmMXP - CLT

2 stops29h 58mMultiple Airlines

Tue 11/185:45 amCLT - MXP

3 stops31h 25mMultiple Airlines

Deal found 10/15

$622

Tue 11/1110:15 amFCO - CLT

1 stop17h 53mMultiple Airlines

Tue 11/255:35 amCLT - FCO

1 stop19h 30mMultiple Airlines

Deal found 10/16

$641

Sat 11/16:10 pmFCO - CLT

1 stop30h 28mMultiple Airlines

Sat 11/84:55 pmCLT - FCO

1 stop15h 35mMultiple Airlines

Deal found 10/16

$645

Mon 11/37:50 pmMXP - CLT

2 stops30h 08mMultiple Airlines

Sun 11/95:45 amCLT - MXP

2 stops31h 25mMultiple Airlines

Deal found 10/16

$648

Thu 11/132:40 pmMXP - CLT

2 stops15h 18mLufthansa

Wed 11/195:35 pmCLT - MXP

1 stop13h 30mLufthansa

Deal found 10/16

$655

Mon 11/109:10 amMXP - CLT

2 stops17h 47mAir Canada

Tue 11/189:30 amCLT - MXP

2 stops42h 25mAir Canada

Deal found 10/15

$656

Fri 11/219:45 amFCO - CLT

2 stops17h 12mAir Canada

Thu 12/45:05 pmCLT - FCO

2 stops34h 20mAir Canada

Deal found 10/16

$657

Sat 11/18:00 amMXP - CLT

1 stop14h 55mLufthansa

Wed 11/52:50 pmCLT - MXP

2 stops17h 05mLufthansa

Deal found 10/16

$668

Best flights from Italy to South Carolina
Discover carefully curated flight deals from Italy to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 16, 2025.

Thu 11/207:00 amFCO - CLT

2 stops31h 49mMultiple Airlines

Wed 12/310:17 amCLT - FCO

1 stop22h 13mMultiple Airlines

Deal found 10/15

$571

Fri 2/131:45 pmBLQ - CLT

1 stop35h 20mAmerican Airlines

Sun 3/89:20 pmCLT - BLQ

1 stop17h 00mAmerican Airlines

Deal found 10/16

$663

Thu 11/1310:40 amMXP - CLT

2 stops16h 17mAir Canada

Wed 11/199:30 amCLT - MXP

2 stops18h 25mAir Canada

Deal found 10/16

$667

Sat 11/18:00 amMXP - CLT

1 stop14h 55mLufthansa

Wed 11/52:50 pmCLT - MXP

2 stops17h 05mLufthansa

Deal found 10/16

$668

Mon 11/1010:25 amMXP - CLT

1 stop17h 10mFinnair

Tue 11/188:12 amCLT - MXP

1 stop17h 53mFinnair

Deal found 10/15

$673

Thu 2/56:55 amVCE - CLT

1 stop15h 10mBritish Airways

Sat 2/148:06 pmCLT - VCE

2 stops13h 49mBritish Airways

Deal found 10/16

$676

Fri 2/612:45 pmFCO - CHS

2 stops34h 02mKLM

Sun 2/812:15 pmCHS - FCO

2 stops17h 40mKLM

Deal found 10/14

$683

Mon 11/102:15 pmNAP - CLT

2 stops26h 17mUnited Airlines

Sun 11/161:56 pmCLT - NAP

2 stops21h 29mUnited Airlines

Deal found 10/15

$691

Thu 11/206:10 amFCO - CLT

2 stops21h 41mDelta

Wed 12/36:45 pmCLT - FCO

2 stops16h 40mDelta

Deal found 10/15

$706

Mon 11/108:00 pmMXP - CLT

2 stops29h 58mMultiple Airlines

Tue 11/185:45 amCLT - MXP

3 stops31h 25mMultiple Airlines

Deal found 10/15

$622

Sun 2/157:15 amBLQ - CLT

1 stop17h 50mAmerican Airlines

Tue 3/107:30 pmCLT - BLQ

1 stop15h 20mAmerican Airlines

Deal found 10/16

$663

Thu 11/1310:25 amMXP - CLT

1 stop12h 45mFinnair

Wed 11/198:22 amCLT - MXP

1 stop17h 43mFinnair

Deal found 10/16

$676

Thu 11/137:05 pmNAP - CLT

2 stops29h 46mLufthansa

Mon 11/176:50 pmCLT - NAP

1 stop16h 35mLufthansa

Deal found 10/16

$676

Fri 12/1211:00 amFCO - CLT

1 stop18h 12mBritish Airways

Tue 1/138:20 pmCLT - FCO

1 stop14h 35mBritish Airways

Deal found 10/16

$682

Thu 11/1310:25 amMXP - CLT

1 stop18h 43mMultiple Airlines

Wed 11/195:45 amCLT - MXP

2 stops22h 00mMultiple Airlines

Deal found 10/16

$629

Fri 12/121:35 pmFCO - CLT

2 stops37h 22mAir Canada

Fri 1/169:30 amCLT - FCO

2 stops17h 55mAir Canada

Deal found 10/16

$694

Fri 11/146:10 amLIN - CLT

2 stops17h 10mUnited Airlines

Tue 11/187:44 pmCLT - LIN

2 stops15h 11mUnited Airlines

Deal found 10/14

$700

Wed 3/410:05 amFCO - CLT

2 stops17h 45mDelta

Wed 3/181:15 pmCLT - FCO

2 stops14h 40mDelta

Deal found 10/16

$709

Mon 2/167:15 amBLQ - CLT

1 stop17h 50mAmerican Airlines

Fri 3/611:00 pmCLT - BLQ

1 stop30h 20mAmerican Airlines

Deal found 10/16

$663

Wed 11/127:05 amFCO - CLT

2 stops20h 59mUnited Airlines

Sun 11/161:56 pmCLT - FCO

1 stop11h 59mUnited Airlines

Deal found 10/14

$701

Thu 2/196:15 amNAP - MYR

2 stops41h 41mDelta

Mon 2/2310:55 amMYR - NAP

2 stops28h 20mDelta

Deal found 10/14

$719

Fri 2/131:45 pmBLQ - CLT

1 stop35h 20mAmerican Airlines

Sat 3/711:00 pmCLT - BLQ

1 stop30h 50mAmerican Airlines

Deal found 10/16

$663

Mon 11/37:50 pmMXP - CLT

2 stops30h 08mMultiple Airlines

Sun 11/95:45 amCLT - MXP

3 stops31h 25mMultiple Airlines

Deal found 10/16

$667

Thu 11/611:05 amVCE - GSP

1 stop18h 51mLufthansa

Mon 11/102:55 pmGSP - VCE

2 stops15h 25mLufthansa

Deal found 10/15

$739

Fri 2/67:05 amFCO - CHS

2 stops17h 59mUnited Airlines

Sun 2/82:58 pmCHS - FCO

1 stop11h 32mUnited Airlines

Deal found 10/14

$701

Sat 11/1510:05 amFCO - CHS

2 stops16h 27mDelta

Sun 11/236:00 amCHS - FCO

1 stop21h 45mDelta

Deal found 10/15

$721

Fri 2/131:45 pmBLQ - CLT

1 stop35h 20mAmerican Airlines

Mon 3/94:16 pmCLT - BLQ

2 stops14h 24mAmerican Airlines

Deal found 10/16

$663

Thu 11/137:20 amLIN - CLT

2 stops17h 05mMultiple Airlines

Wed 11/195:45 amCLT - LIN

2 stops22h 20mMultiple Airlines

Deal found 10/16

$673

Mon 12/157:05 amFCO - CLT

2 stops33h 27mUnited Airlines

Thu 1/159:55 amCLT - FCO

1 stop16h 35mUnited Airlines

Deal found 10/16

$704

Sun 2/157:15 amBLQ - CLT

1 stop17h 50mAmerican Airlines

Sun 3/82:30 pmCLT - BLQ

2 stops16h 20mAmerican Airlines

Deal found 10/16

$663

Last-minute flights from Italy to South Carolina
Discover last-minute flight deals from Italy to South Carolina. Data last updated October 16, 2025 and is based on user searches.

Sat 11/16:10 pmFCO - CLT

1 stop30h 28mMultiple Airlines

Sat 11/84:55 pmCLT - FCO

1 stop15h 35mMultiple Airlines

Deal found 10/16

$645

Sat 11/18:00 amMXP - CLT

1 stop14h 55mLufthansa

Wed 11/52:50 pmCLT - MXP

2 stops17h 05mLufthansa

Deal found 10/16

$668

Mon 11/37:50 pmMXP - CLT

2 stops30h 08mMultiple Airlines

Sun 11/95:45 amCLT - MXP

2 stops31h 25mMultiple Airlines

Deal found 10/16

$648

Mon 11/108:00 pmMXP - CLT

2 stops29h 58mMultiple Airlines

Tue 11/185:45 amCLT - MXP

3 stops31h 25mMultiple Airlines

Deal found 10/15

$622

Mon 11/109:10 amMXP - CLT

2 stops17h 47mAir Canada

Tue 11/189:30 amCLT - MXP

2 stops42h 25mAir Canada

Deal found 10/15

$656

Tue 11/1110:15 amFCO - CLT

1 stop17h 53mMultiple Airlines

Tue 11/255:35 amCLT - FCO

1 stop19h 30mMultiple Airlines

Deal found 10/16

$641

Thu 11/139:15 amMXP - CLT

2 stops19h 53mMultiple Airlines

Wed 11/195:45 amCLT - MXP

2 stops22h 40mMultiple Airlines

Deal found 10/16

$522

Thu 11/136:30 amLIN - CLT

2 stops22h 38mMultiple Airlines

Wed 11/195:45 amCLT - LIN

2 stops22h 25mMultiple Airlines

Deal found 10/16

$605

Thu 11/132:40 pmMXP - CLT

2 stops15h 18mLufthansa

Wed 11/195:35 pmCLT - MXP

1 stop13h 30mLufthansa

Deal found 10/16

$655

Thu 11/207:00 amFCO - CLT

2 stops31h 49mMultiple Airlines

Wed 12/310:17 amCLT - FCO

1 stop22h 13mMultiple Airlines

Deal found 10/15

$571

Fri 11/217:10 pmFCO - CLT

1 stop31h 15mMultiple Airlines

Thu 12/49:00 amCLT - FCO

2 stops23h 30mMultiple Airlines

Deal found 10/16

$558

Fri 11/219:45 amFCO - CLT

2 stops17h 12mAir Canada

Thu 12/45:05 pmCLT - FCO

2 stops34h 20mAir Canada

Deal found 10/16

$657

One-way flights from Italy to South Carolina
Search for one-way flight options from Italy to South Carolina. Find affordable one-way fares based on user searches. Data last updated October 16, 2025.

Fri 12/127:10 pmFCO - CLT

2 stops51h 39mMultiple Airlines

Deal found 10/16

$313

Thu 12/117:10 pmFCO - CLT

2 stops30h 00mMultiple Airlines

Deal found 10/15

$337

Mon 12/87:10 amMXP - CLT

2 stops37h 37mMultiple Airlines

Deal found 10/16

$342

Mon 2/911:15 pmVCE - CLT

2 stops49h 21mMultiple Airlines

Deal found 10/15

$352

Fri 1/168:50 pmFCO - CLT

2 stops41h 13mMultiple Airlines

Deal found 10/16

$360

Sat 12/137:10 pmFCO - CLT

2 stops44h 27mMultiple Airlines

Deal found 10/16

$370

Wed 11/128:30 pmFCO - CLT

2 stops48h 15mMultiple Airlines

Deal found 10/16

$373

Thu 11/1311:45 amFCO - CLT

3 stops57h 11mMultiple Airlines

Deal found 10/15

$379

Mon 11/106:00 amMXP - CLT

2 stops44h 10mMultiple Airlines

Deal found 10/15

$382

Sat 11/155:45 amFCO - CLT

2 stops39h 00mMultiple Airlines

Deal found 10/15

$384

Tue 11/1110:30 pmFCO - CLT

3 stops46h 25mMultiple Airlines

Deal found 10/15

$386

Sat 12/67:15 pmMXP - CLT

1 stop24h 55mMultiple Airlines

Deal found 10/16

$391

Cheap flight deals from Italy to South Carolina

Round-trip from	$522 (flugladen.de)
One-way from	$313 (Kiwi.com)

From Italy to South Carolina

Search Deals

One-way flight from Italy to South Carolina

Search Deals

Cheapflights Fare Finder

Use the filters below to find and compare flights from Italy to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

RomeCharlotte

FCO - CLT

FCOCLT

Rome Fiumicino

Thu 11/20

7:00 am-8:49 am

2 stops31h 49m

Charlotte Douglas

Wed 12/3

10:17 am-2:30 pm

1 stop22h 13m

$571

MilanCharlotte

MXP - CLT

MXPCLT

Milan Malpensa

Mon 11/10

8:00 pm-7:58 pm

2 stops29h 58m

Charlotte Douglas

Tue 11/18

5:45 am-7:10 pm

3 stops31h 25m

$622

MilanCharlotte

MXP - CLT

MXPCLT

Milan Malpensa

Thu 11/13

10:25 am-11:08 pm

1 stop18h 43m

Charlotte Douglas

Wed 11/19

5:45 am-9:45 am

2 stops22h 00m

$629

BolognaCharlotte

BLQ - CLT

BLQCLT

Bologna Guglielmo Marconi

Fri 2/13

1:45 pm-7:05 pm

1 stop35h 20m

Charlotte Douglas

Sun 3/8

9:20 pm-7:20 pm

1 stop17h 00m

$663

BolognaCharlotte

BLQ - CLT

BLQCLT

Bologna Guglielmo Marconi

Sun 2/15

7:15 am-7:05 pm

1 stop17h 50m

Charlotte Douglas

Tue 3/10

7:30 pm-3:50 pm

1 stop15h 20m

$663

BolognaCharlotte

BLQ - CLT

BLQCLT

Bologna Guglielmo Marconi

Mon 2/16

7:15 am-7:05 pm

1 stop17h 50m

Charlotte Douglas

Fri 3/6

11:00 pm-11:20 am

1 stop30h 20m

$663

BolognaCharlotte

BLQ - CLT

BLQCLT

Bologna Guglielmo Marconi

Fri 2/13

1:45 pm-7:05 pm

1 stop35h 20m

Charlotte Douglas

Sat 3/7

11:00 pm-11:50 am

1 stop30h 50m

$663

BolognaCharlotte

BLQ - CLT

BLQCLT

Bologna Guglielmo Marconi

Fri 2/13

1:45 pm-7:05 pm

1 stop35h 20m

Charlotte Douglas

Mon 3/9

4:16 pm-11:40 am

2 stops14h 24m

$663

BolognaCharlotte

BLQ - CLT

BLQCLT

Bologna Guglielmo Marconi

Sun 2/15

7:15 am-7:05 pm

1 stop17h 50m

Charlotte Douglas

Sun 3/8

2:30 pm-11:50 am

2 stops16h 20m

$663

MilanCharlotte

MXP - CLT

MXPCLT

Milan Malpensa

Thu 11/13

10:40 am-8:57 pm

2 stops16h 17m

Charlotte Douglas

Wed 11/19

9:30 am-9:55 am

2 stops18h 25m

$667

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/16

Showing 1-10 of 60 results

...

Best time to book a flight from Italy to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Italy with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Italy to South Carolina

What is the cheapest time of day to fly from IT to SC?

It’s optimal to fly from Italy to South Carolina in the afternoon. By choosing this option you can save up to 15% on the cost of your flight, compared to a flight in the evening.

Reviews of airlines servicing South Carolina

Read reviews from past customers who have flown Lufthansa from Italy to South Carolina. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Lufthansa

6.8

Okay

7,497 reviews

Reviews

1 / 20

8.0

Excellent

Anonymous,Jan 2025

FRA - TPA

I had ordered a gluten-free meal through you I double triple checked that through you got screamed at by one of your representatives. She yelled at me and said that she had ordered the mail, she had chosen my seat, and made sure that all my baggage is were paid for. That was a lie. My experience with discover airlines in and of itself was GOOD but your representative was out of line did not do anything that she screamed at me and told me she did and I literally had to call the airlines myself to get my seat selected to double check on my gluten-free meal which still was not on board and to pay for my bags which I thought that I paid for all of them until I got to the airport and I still had to pay for my check back. So cheap flights I will never use you again.

Lufthansa

6.8

Okay

7,497 reviews

Lufthansa

6.8

Okay

7,497 reviews

Reviews

1 / 20

8.0

Excellent

Anonymous,Jan 2025

FRA - TPA

Related info for your journey

How long is the flight from Italy to South Carolina?
A quick flight from Italy to South Carolina can take about 16h 17m. American Airlines provides one of the quickest options available for as low as $667. The distance from Italy to South Carolina is about 4519 mi. This flight may include one or multiple stops.
Can I find deals for flights from Italy to South Carolina that include hotel bookings?
Yes. In addition to deals on Italy to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Italy to South Carolina?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Italy to South Carolina.
Can I find deals for business class flights from Italy to South Carolina?
Yes. Cheapflights offers flight deals from Italy to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

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$313+ Cheap flights from Italy to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/12. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Italy to South Carolina with Cheapflights

1. Tell us where you want to go

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3. Compare prices and book

Find flight deals from Italy to South Carolina

Cheapest flights from Italy to South CarolinaExplore the most affordable flight options available from Italy to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 16, 2025.

Explore the most affordable flight options available from Italy to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 16, 2025.

Cheap flight deals from Italy to South Carolina

Keep the following information in mind while searching for Italy to South Carolina flight deals. Data was last updated October 16, 2025.

Round-trip from

One-way from

Cheapflights Fare Finder

Use the filters below to find and compare flights from Italy to South Carolina that are best for you.

Best time to book a flight from Italy to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Italy with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Italy to South Carolina

What is the cheapest time of day to fly from IT to SC?

Find hourly flight availability from Italy to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 16, 2025.

Reviews of airlines servicing South Carolina

Read reviews from past customers who have flown Lufthansa from Italy to South Carolina. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Italy to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from Italy to South Carolina?

Can I find deals for flights from Italy to South Carolina that include hotel bookings?

How can I find direct flights from Italy to South Carolina?

Can I find deals for business class flights from Italy to South Carolina?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Italy to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.

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Book with Flexibility

Travel Smart

Cheapest flights from Italy to South Carolina
Explore the most affordable flight options available from Italy to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 16, 2025.