$277+ Cheap flights from Knoxville (TYS) to Santo Domingo (SDQ)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/7. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SDQ
Oct 21 — Oct 281
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Santo Domingo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Santo Domingo
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Cheapest flights from Knoxville to Santo DomingoExplore the most affordable flight options available from Knoxville to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 21, 2026.
Explore the most affordable flight options available from Knoxville to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 21, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/163:54 pm -
2 stops27h 24m
Thu 10/226:10 am -
1 stop29h 54m
Deal found 9/18![Multiple Airlines logo]()
$567
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/185:40 am -
1 stop7h 52m
Thu 12/33:57 pm -
1 stop6h 59m
Deal found 9/16![Delta logo]()
$570
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/226:05 pm -
2 stops15h 17m
Thu 10/292:33 pm -
1 stop8h 26m
Deal found 9/16![American Airlines logo]()
$575
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/186:48 am -
2 stops12h 05m
Thu 12/311:09 am -
1 stop10h 08m
Deal found 9/17![American Airlines logo]()
$580
This Delta deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/165:40 am -
1 stop7h 52m
Thu 10/227:35 pm -
1 stop15h 27m
Deal found 9/18![Delta logo]()
$581
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/197:58 pm -
2 stops17h 35m
Mon 10/267:00 am -
2 stops14h 33m
Deal found 9/21![American Airlines logo]()
$595
This American Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:00 am -
2 stops14h 50m
Thu 10/227:00 am -
2 stops13h 18m
Deal found 9/18![American Airlines logo]()
$626
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/305:47 am -
1 stop8h 04m
Fri 1/2212:36 pm -
1 stop8h 39m
Deal found 9/21![American Airlines logo]()
$638
This American Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/188:18 am -
2 stops10h 16m
Thu 9/242:15 pm -
1 stop8h 52m
Deal found 9/18![American Airlines logo]()
$861
This American Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/186:16 pm -
2 stops18h 55m
Tue 9/224:20 pm -
1 stop6h 47m
Deal found 9/18![American Airlines logo]()
$955
Best flights from Knoxville to Santo DomingoDiscover carefully curated flight deals from Knoxville to Santo Domingo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 21, 2026.
Discover carefully curated flight deals from Knoxville to Santo Domingo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 21, 2026.
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/226:00 am -
1 stop7h 33m
Thu 10/297:00 am -
1 stop15h 59m
Deal found 9/16![American Airlines logo]()
$570
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1811:20 am -
1 stop11h 26m
Thu 12/36:00 am -
1 stop15h 37m
Deal found 9/17![United Airlines logo]()
$570
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/185:40 am -
1 stop7h 52m
Thu 12/33:57 pm -
1 stop6h 59m
Deal found 9/16![Delta logo]()
$570
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/136:00 am -
1 stop11h 25m
Wed 1/2010:58 am -
1 stop14h 01m
Deal found 9/16![American Airlines logo]()
$575
This Delta deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/165:40 am -
1 stop7h 52m
Thu 10/227:35 pm -
1 stop15h 27m
Deal found 9/18![Delta logo]()
$581
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/186:48 am -
2 stops12h 05m
Thu 12/311:09 am -
1 stop10h 08m
Deal found 9/17![American Airlines logo]()
$580
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/176:00 am -
1 stop7h 15m
Sun 1/243:40 pm -
1 stop9h 06m
Deal found 9/17![Delta logo]()
$633
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/197:58 pm -
2 stops17h 35m
Mon 10/267:00 am -
2 stops14h 33m
Deal found 9/21![American Airlines logo]()
$595
Last-minute flights from Knoxville to Santo DomingoDiscover last-minute flight deals from Knoxville to Santo Domingo. Data last updated September 21, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Santo Domingo. Data last updated September 21, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/188:18 am -
2 stops10h 16m
Thu 9/242:15 pm -
1 stop8h 52m
Deal found 9/18![American Airlines logo]()
$861
This American Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/186:16 pm -
2 stops18h 55m
Tue 9/224:20 pm -
1 stop6h 47m
Deal found 9/18![American Airlines logo]()
$955
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/163:54 pm -
2 stops27h 24m
Thu 10/226:10 am -
1 stop29h 54m
Deal found 9/18![Multiple Airlines logo]()
$567
This Delta deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/165:40 am -
1 stop7h 52m
Thu 10/227:35 pm -
1 stop15h 27m
Deal found 9/18![Delta logo]()
$581
This American Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:00 am -
2 stops14h 50m
Thu 10/227:00 am -
2 stops13h 18m
Deal found 9/18![American Airlines logo]()
$626
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/197:58 pm -
2 stops13h 24m
Mon 10/267:00 am -
1 stop15h 59m
Deal found 9/21![American Airlines logo]()
$595
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/226:00 am -
1 stop7h 33m
Thu 10/297:00 am -
1 stop15h 59m
Deal found 9/16![American Airlines logo]()
$570
One-way flights from Knoxville to Santo DomingoSearch for one-way flight options from Knoxville to Santo Domingo. Find affordable one-way fares based on user searches. Data last updated September 21, 2026.
Search for one-way flight options from Knoxville to Santo Domingo. Find affordable one-way fares based on user searches. Data last updated September 21, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/71:58 pm -
3 stops49h 31m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![Multiple Airlines logo]()
$277
This Kiwi.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/174:41 pm -
2 stops26h 37m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![Multiple Airlines logo]()
$278
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/176:00 am -
1 stop14h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![American Airlines logo]()
$354
This American Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/256:00 am -
1 stop7h 11m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/18![American Airlines logo]()
$408
This Kiwi.com deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/266:55 pm -
2 stops24h 23m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/20![Multiple Airlines logo]()
$425
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/251:54 pm -
3 stops21h 48m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/18![Multiple Airlines logo]()
$462
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/266:05 am -
1 stop9h 12m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/20![American Airlines logo]()
$473
This Mytrip deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/278:30 pm -
2 stops22h 19m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/20![Multiple Airlines logo]()
$494
Find flight deals from Knoxville to Santo Domingo
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Santo Domingo (SDQ). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 21, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $567 (Kiwi.com) |
One-way from | $277 (Kiwi.com) |
Popular in | August |
Cheapest in | March |
Average price | $735 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 21, 2026.
Use the filters below to find and compare flights from Knoxville to Santo Domingo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleSanto Domingo
TYS Knoxville McGhee Tyson - SDQ Santo Domingo Las Americas
TYSSDQ
Knoxville McGhee Tyson
Sat 10/17
4:41 pm-7:18 pm
2 stops26h 37m
Santo Domingo Las Americas
Wed 12/31
12:00 am-11:30 pm
Nonstop0h 00m
$278
KnoxvilleSanto Domingo
TYS Knoxville McGhee Tyson - SDQ Santo Domingo Las Americas
TYSSDQ
Knoxville McGhee Tyson
Mon 12/7
1:58 pm-11:11 am
1 stop20h 13m
Santo Domingo Las Americas
Wed 12/31
12:00 am-11:30 pm
Nonstop0h 00m
$283
KnoxvilleSanto Domingo
TYS Knoxville McGhee Tyson - SDQ Santo Domingo Las Americas
TYSSDQ
Knoxville McGhee Tyson
Sat 10/17
6:00 am-8:50 pm
1 stop14h 50m
Santo Domingo Las Americas
Wed 12/31
12:00 am-11:30 pm
Nonstop0h 00m
$354
Quickest round-trip
KnoxvilleSanto Domingo
TYS Knoxville McGhee Tyson - SDQ Santo Domingo Las Americas
TYSSDQ
Knoxville McGhee Tyson
Fri 9/25
6:00 am-1:11 pm
1 stop7h 11m
Santo Domingo Las Americas
Wed 12/31
12:00 am-11:30 pm
Nonstop0h 00m
$408
KnoxvilleSanto Domingo
TYS Knoxville McGhee Tyson - SDQ Santo Domingo Las Americas
TYSSDQ
Knoxville McGhee Tyson
Sat 9/26
6:55 pm-7:18 pm
2 stops24h 23m
Santo Domingo Las Americas
Wed 12/31
12:00 am-11:30 pm
Nonstop0h 00m
$425
KnoxvilleSanto Domingo
TYS Knoxville McGhee Tyson - SDQ Santo Domingo Las Americas
TYSSDQ
Knoxville McGhee Tyson
Sat 9/26
6:05 am-3:17 pm
1 stop9h 12m
Santo Domingo Las Americas
Wed 12/31
12:00 am-11:30 pm
Nonstop0h 00m
$473
KnoxvilleSanto Domingo
TYS Knoxville McGhee Tyson - SDQ Santo Domingo Las Americas
TYSSDQ
Knoxville McGhee Tyson
Sun 9/27
8:30 pm-6:49 pm
2 stops22h 19m
Santo Domingo Las Americas
Wed 12/31
12:00 am-11:30 pm
Nonstop0h 00m
$494
KnoxvilleSanto Domingo
TYS Knoxville McGhee Tyson - SDQ Santo Domingo Las Americas
TYSSDQ
Knoxville McGhee Tyson
Thu 10/22
6:00 am-1:33 pm
1 stop7h 33m
Santo Domingo Las Americas
Thu 10/29
7:00 am-10:59 pm
1 stop15h 59m
$570
KnoxvilleSanto Domingo
TYS Knoxville McGhee Tyson - SDQ Santo Domingo Las Americas
TYSSDQ
Knoxville McGhee Tyson
Wed 11/18
11:20 am-11:46 pm
1 stop11h 26m
Santo Domingo Las Americas
Thu 12/3
6:00 am-8:37 pm
1 stop15h 37m
$570
KnoxvilleSanto Domingo
TYS Knoxville McGhee Tyson - SDQ Santo Domingo Las Americas
TYSSDQ
Knoxville McGhee Tyson
Wed 11/18
5:40 am-2:32 pm
1 stop7h 52m
Santo Domingo Las Americas
Thu 12/3
3:57 pm-9:56 pm
1 stop6h 59m
$570
Showing 1-10 of 15 resultsSorted by cheapest first
Compare providers for flights from Knoxville to Santo Domingo
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Santo Domingo in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-Santo Domingo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Santo Domingo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Santo Domingo flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Santo Domingo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Santo Domingo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Santo Domingo
Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Knoxville with our price prediction graph.
TYS-SDQ
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Santo Domingo
Reviews of airlines servicing Santo Domingo
Get insights into the airlines that provide service to Santo Domingo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santo Domingo. Reviews last updated September 21, 2026.
Peruse reviews from past customers who have flown with Delta and American Airlines from Knoxville to Santo Domingo to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Food
7.2
Overall
7.8
Comfort
7.8
Entertainment
7.8
Crew
8.5
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Boarding
8.1
Food
7.2
Overall
7.8
Comfort
7.8
Entertainment
7.8
Crew
8.5
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Boarding
8.1
Food
7.2
Overall
7.8
Comfort
7.8
Entertainment
7.8
Crew
8.5
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Santo Domingo?
Book flights to Santo Domingo if you plan to visit one of these locationsJuan Dolio
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Knoxville and Santo Domingo flights
Browse other Knoxville and Santo Domingo flight options. Last updated on September 21, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on September 21, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santo Domingo
Explore flights to Santo Domingo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 21, 2026.
Top 2 airlines flying from Knoxville to Santo Domingo
Discover the top 2 airlines that operate flights from Knoxville to Santo Domingo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 21, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$399 | Average$609 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$435 | Average$664 | FlexibilityNo cancel fee | On-timeN/A |