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Santiago de los Caballeros

$120+ Cheap flights from Key Largo, FL to Santiago de los Caballeros (STI)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/25. Fares are subject to change and may not be available on all flights or dates of travel.
MIA — STI
Feb 28 — Mar 71
Sat 2/28
Sat 3/7
1 adult, Economy
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Cheapflights Tip: The best prices from Key Largo to Santiago de los Caballeros are usually found in January or October, booked 55 days in advance, depart on a Thursday or Tuesday and return on a Tuesday

Cheap flight deals from Key Largo to Santiago de los Caballeros

Cheapest flights from Key Largo to Santiago de los Caballeros
Explore the most affordable flight options available from Key Largo to Santiago de los Caballeros. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 29, 2026.

This American Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/46:33 pm
MIA
-
STI
Nonstop2h 13m
American Airlines
Sun 2/86:00 am
STI
-
MIA
Nonstop2h 23m
American Airlines
Deal found 1/28$249
This American Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/56:33 pm
MIA
-
STI
Nonstop2h 13m
American Airlines
Sat 2/76:00 am
STI
-
MIA
Nonstop2h 23m
American Airlines
Deal found 1/28$250
This American Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/66:16 pm
MIA
-
STI
Nonstop2h 14m
American Airlines
Mon 3/97:00 am
STI
-
MIA
Nonstop2h 29m
American Airlines
Deal found 1/28$252
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/812:20 pm
MIA
-
STI
Nonstop2h 12m
American Airlines
Wed 2/114:33 pm
STI
-
MIA
Nonstop2h 32m
American Airlines
Deal found 1/27$261
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/266:15 pm
MIA
-
STI
Nonstop2h 14m
American Airlines
Tue 3/317:00 am
STI
-
MIA
Nonstop2h 29m
American Airlines
Deal found 1/27$263
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/56:33 pm
MIA
-
STI
Nonstop2h 13m
American Airlines
Mon 2/96:00 am
STI
-
MIA
Nonstop2h 23m
American Airlines
Deal found 1/27$264
This American Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/106:33 pm
MIA
-
STI
Nonstop2h 13m
American Airlines
Tue 5/51:32 pm
STI
-
MIA
Nonstop2h 23m
American Airlines
Deal found 1/28$265
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/76:33 pm
MIA
-
STI
Nonstop2h 13m
American Airlines
Thu 2/192:31 pm
STI
-
MIA
Nonstop2h 28m
American Airlines
Deal found 1/27$267
This American Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/116:33 pm
MIA
-
STI
Nonstop2h 13m
American Airlines
Wed 2/188:00 am
STI
-
MIA
Nonstop2h 29m
American Airlines
Deal found 1/28$274
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/1610:10 am
MIA
-
STI
Nonstop2h 13m
American Airlines
Thu 4/231:32 pm
STI
-
MIA
Nonstop2h 23m
American Airlines
Deal found 1/27$275
This American Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/1610:10 am
MIA
-
STI
Nonstop2h 13m
American Airlines
Mon 4/201:32 pm
STI
-
MIA
Nonstop2h 23m
American Airlines
Deal found 1/28$278

Find flight deals from Key Largo to Santiago de los Caballeros

Keep the following information in mind while searching for Key Largo to Santiago de los Caballeros flight deals. Data was last updated January 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$252
(American Airlines)

One-way from

$120
(American Airlines)

Popular in

December

Cheapest in

January

Average price

$349
Provider with most accurate pricing for Miami-Santiago de los Caballeros flight deals.
Search Deals
Provider most trusted by Cheapflights users for Miami-Santiago de los Caballeros flights.
Search Deals
From Key Largo to Santiago de los Caballeros
Search Deals
One-way flight from Key Largo to Santiago de los Caballeros
Search Deals
High demand for flights, 3% potential price rise
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($11 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Key Largo to Santiago de los Caballeros that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Key Largo to Santiago de los Caballeros that are best for you.

Fly from

Key Largo

Fly to

Santiago de los Caballeros

Route

Depart

Return

Price

MiamiSantiago de los Caballeros

MIA - STI

MIASTI

Miami

Fri 3/6

6:16 pm-9:30 pm

Nonstop2h 14m

Santiago de los Caballeros

Mon 3/9

7:00 am-9:29 am

Nonstop2h 29m

$252

MiamiSantiago de los Caballeros

MIA - STI

MIASTI

Miami

Thu 4/16

10:10 am-12:23 pm

Nonstop2h 13m

Santiago de los Caballeros

Mon 4/20

1:32 pm-3:55 pm

Nonstop2h 23m

$278

MiamiSantiago de los Caballeros

MIA - STI

MIASTI

Miami

Wed 2/25

6:16 pm-9:30 pm

Nonstop2h 14m

Santiago de los Caballeros

Mon 3/2

8:00 am-9:29 am

Nonstop2h 29m

$307

MiamiSantiago de los Caballeros

MIA - STI

MIASTI

Miami

Fri 2/20

6:16 pm-9:30 pm

Nonstop2h 14m

Santiago de los Caballeros

Sun 3/1

8:00 am-9:29 am

Nonstop2h 29m

$309

MiamiSantiago de los Caballeros

MIA - STI

MIASTI

Miami

Wed 3/25

6:15 pm-8:29 pm

Nonstop2h 14m

Santiago de los Caballeros

Sun 4/5

7:00 am-9:29 am

Nonstop2h 29m

$310

MiamiSantiago de los Caballeros

MIA - STI

MIASTI

Miami

Thu 3/26

6:01 am-2:56 pm

1 stop8h 55m

Santiago de los Caballeros

Mon 3/30

3:51 pm-10:42 pm

1 stop6h 51m

$323

MiamiSantiago de los Caballeros

MIA - STI

MIASTI

Miami

Wed 2/18

6:16 pm-9:30 pm

Nonstop2h 14m

Santiago de los Caballeros

Sun 2/22

8:00 am-9:29 am

Nonstop2h 29m

$337

MiamiSantiago de los Caballeros

MIA - STI

MIASTI

Miami

Thu 4/23

6:00 am-2:50 pm

1 stop8h 50m

Santiago de los Caballeros

Mon 4/27

3:59 pm-10:42 pm

1 stop6h 43m

$357

MiamiSantiago de los Caballeros

MIA - STI

MIASTI

Miami

Thu 4/16

6:00 am-2:50 pm

1 stop8h 50m

Santiago de los Caballeros

Thu 4/23

3:59 pm-10:42 pm

1 stop6h 43m

$357

MiamiSantiago de los Caballeros

MIA - STI

MIASTI

Miami

Thu 5/14

6:00 am-2:50 pm

1 stop8h 50m

Santiago de los Caballeros

Mon 5/18

3:59 pm-10:42 pm

1 stop6h 43m

$357

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/27

Showing 1-10 of 22 results
1
2
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Best time to book a flight from Key Largo to Santiago de los Caballeros

Have a flexible travel schedule? Discover the best time to fly to Santiago de los Caballeros from Key Largo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key Largo to Santiago de los Caballeros

How far ahead should I book a flight from Key Largo to Santiago de los Caballeros?

Use this chart to determine the optimal time to book a round-trip flight from Key Largo to Santiago de los Caballeros. Price data was last updated on January 23, 2026.

The best time to book flights from Key Largo to Santiago de los Caballeros is 55 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Key Largo to Santiago de los Caballeros?

Currently, April is the cheapest month in which you can book a flight from Key Largo to Santiago de los Caballeros (average of $123). Flying from Key Largo to Santiago de los Caballeros in November is currently the most expensive (average of $172). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from KE9 to STI?

Find hourly flight availability from Key Largo to Santiago de los Caballeros. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 29, 2026.

It’s typically best to fly out from Key Largo to Santiago de los Caballeros in the morning. Doing so could potentially save you 11% on the flight price compared to flying in the afternoon, which is usually more expensive.

What is the cheapest day to fly from Key Largo to Santiago de los Caballeros?

Use this chart to determine the cheapest time to fly round-trip from Key Largo to Santiago de los Caballeros. Price data was last updated on January 24, 2026.

Travelers seeking maximum savings on their Key Largo to Santiago de los Caballeros flight should consider departing on Thursday at noon when fares are most often at their lowest. Saturday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Key Largo to Santiago de los Caballeros

Explore weekly flight availability from Key Largo to Santiago de los Caballeros. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated January 29, 2026.

The most flights from KE9 to STI are scheduled on a Thursday (4 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (2 on average).

Reviews of airlines servicing Santiago de los Caballeros

Get insights into the airlines that provide service to Santiago de los Caballeros. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago de los Caballeros. Reviews last updated January 29, 2026.
Peruse reviews from past customers who have flown with American Airlines, JetBlue, and Spirit Airlines from Key Largo to Santiago de los Caballeros to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,206 reviews

Comfort

7.2

Crew

8.0

Boarding

7.5

Food

6.4

Entertainment

6.9

Overall

7.2

Reviews

1 / 20
4.0
Okay

Susie,Jan 2026

TPA - CLT

I was sitting at the back of the plane and the flight attendants were so loud, talking to each other and laughing! I thought they were having a party back there.
American Airlines
7.2
Good
11,206 reviews
American Airlines
7.2
Good
11,206 reviews

Comfort

7.2

Crew

8.0

Boarding

7.5

Food

6.4

Entertainment

6.9

Overall

7.2

Reviews

1 / 20
4.0
Okay

Susie,Jan 2026

TPA - CLT

I was sitting at the back of the plane and the flight attendants were so loud, talking to each other and laughing! I thought they were having a party back there.
JetBlue
7.2
Good
2,891 reviews
American Airlines
7.2
Good
11,206 reviews

Comfort

7.2

Crew

8.0

Boarding

7.5

Food

6.4

Entertainment

6.9

Overall

7.2

Reviews

1 / 20
4.0
Okay

Susie,Jan 2026

TPA - CLT

I was sitting at the back of the plane and the flight attendants were so loud, talking to each other and laughing! I thought they were having a party back there.
Spirit Airlines
6.3
Okay
8,394 reviews
American Airlines
7.2
Good
11,206 reviews

Comfort

7.2

Crew

8.0

Boarding

7.5

Food

6.4

Entertainment

6.9

Overall

7.2

Reviews

1 / 20
4.0
Okay

Susie,Jan 2026

TPA - CLT

I was sitting at the back of the plane and the flight attendants were so loud, talking to each other and laughing! I thought they were having a party back there.
Frontier
5.7
Fair
3,056 reviews
American Airlines
7.2
Good
11,206 reviews

Comfort

7.2

Crew

8.0

Boarding

7.5

Food

6.4

Entertainment

6.9

Overall

7.2

Reviews

1 / 20
4.0
Okay

Susie,Jan 2026

TPA - CLT

I was sitting at the back of the plane and the flight attendants were so loud, talking to each other and laughing! I thought they were having a party back there.

Related info for your journey

Find useful and relevant information for your journey from Key Largo to Santiago de los Caballeros. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santiago de los Caballeros from Key Largo?

    Most people fly into Santiago de los Caballeros (STI) if they book a flight to Santiago de los Caballeros from Key Largo. On average, Santiago has 3 inbound flights from Key Largo per day from 4 airlines. Santiago de los Caballeros is conveniently located just 6.8 mi from Santiago de los Caballeros’s city center.

  • How popular is this Key Largo to Santiago de los Caballeros flight route?

    Flights from Key Largo to Santiago de los Caballeros have been viewed 2 times in the past calendar month.

  • How long is the flight from Key Largo to Santiago de los Caballeros?

    A quick flight from Key Largo to Santiago de los Caballeros can take about 2h 14m. American Airlines provides one of the quickest options available for as low as $252. There are 758 mi between Key Largo and Santiago de los Caballeros. Generally, flights for this route are nonstop.

  • What are the cheapest airlines to fly from Key Largo to Santiago de los Caballeros one-way?

    The cheapest airline one-way is Frontier, with whom users have recently found tickets for as low as $92. However, be on the lookout for offers from Spirit Airlines and American Airlines, as they are both options that can get you from Key Largo to Santiago de los Caballeros for a low price.

  • What are the cheapest flights from Key Largo to Santiago de los Caballeros?

    On average you can expect to pay $272 for a flight from Key Largo to Santiago de los Caballeros. The cheapest flight overall is $140 while the most popular route, (Miami - Santiago de los Caballeros) is currently priced at $289.

  • Can I find deals for flights from Key Largo to Santiago de los Caballeros that include hotel bookings?

    Yes. In addition to deals on Key Largo to Santiago de los Caballeros flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key Largo to Santiago de los Caballeros?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key Largo to Santiago de los Caballeros.

  • Can I find deals for business class flights from Key Largo to Santiago de los Caballeros?

    Yes. Cheapflights offers flight deals from Key Largo to Santiago de los Caballeros by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Key Largo to Santiago de los Caballeros?

    Currently, April is the cheapest month in which you can book a flight from Key Largo to Santiago de los Caballeros (average of $123). Flying from Key Largo to Santiago de los Caballeros in November is currently the most expensive (average of $172). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Key Largo to Santiago de los Caballeros

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Key Largo to Santiago de los Caballeros

Discover the top 4 airlines that operate flights from Key Largo to Santiago de los Caballeros. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
JetBlueCheapest$208Average$428FlexibilityNo cancel feeOn-time62%
Spirit AirlinesCheapest$211Average$306FlexibilityNo cancel feeOn-time65%
FrontierCheapest$225Average$371FlexibilityNo cancel feeOn-time62%
American AirlinesCheapest$261Average$456FlexibilityNo cancel feeOn-time71%

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