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Santiago de los Caballeros

$145+ Cheap flights from Key Largo, FL to Santiago de los Caballeros (STI)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/7. Fares are subject to change and may not be available on all flights or dates of travel.
MIA — STI
nov. 29 — dic. 61
sáb. 11/29
sáb. 12/6
1 adult, Economy
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Cheapflights Tip: The best prices from Key Largo to Santiago de los Caballeros are usually found in October or November, booked 54 days in advance, depart on a Thursday or Wednesday and return on a Friday

Cheap flight deals from Key Largo to Santiago de los Caballeros

Keep the following information in mind while searching for Key Largo to Santiago de los Caballeros flight deals. Data was last updated octubre 30, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$289
(American Airlines)

One-way from

$145
(American Airlines)

Popular in

December

Cheapest in

October

Average price

$353
Provider with most accurate pricing for Miami-Santiago de los Caballeros flight deals.
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Provider most trusted by Cheapflights users for Miami-Santiago de los Caballeros flights.
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From Key Largo to Santiago de los Caballeros
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One-way flight from Key Largo to Santiago de los Caballeros
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Highest demand for flights based on searches. 11% potential increase in price ($63 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($18 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Key Largo to Santiago de los Caballeros

Cheapest flights from Key Largo to Santiago de los Caballeros
Explore the most affordable flight options available from Key Largo to Santiago de los Caballeros. Find the lowest fares from popular airlines and budget airlines, with prices last updated on octubre 30, 2025.

This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/2712:14 pmMIA - STI
Nonstop2h 18mAmerican Airlines
vie. 12/56:00 amSTI - MIA
Nonstop2h 21mAmerican Airlines
Deal found 10/30$289
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 11/257:44 pmMIA - STI
Nonstop2h 12mAmerican Airlines
mar. 12/26:20 amSTI - MIA
Nonstop2h 15mAmerican Airlines
Deal found 10/30$299
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 11/247:44 pmMIA - STI
Nonstop2h 12mAmerican Airlines
lun. 12/16:20 amSTI - MIA
Nonstop2h 15mAmerican Airlines
Deal found 10/30$309
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 11/1112:15 pmMIA - STI
Nonstop2h 18mAmerican Airlines
lun. 11/177:00 amSTI - MIA
Nonstop2h 15mAmerican Airlines
Deal found 10/28$311
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 11/105:45 pmMIA - STI
Nonstop2h 06mAmerican Airlines
sáb. 11/157:00 amSTI - MIA
Nonstop2h 15mAmerican Airlines
Deal found 10/29$314
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 11/412:15 pmMIA - STI
Nonstop2h 18mAmerican Airlines
mar. 11/117:00 amSTI - MIA
Nonstop2h 15mAmerican Airlines
Deal found 10/30$316
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 11/165:45 pmMIA - STI
Nonstop2h 06mAmerican Airlines
sáb. 11/224:35 pmSTI - MIA
Nonstop2h 18mAmerican Airlines
Deal found 10/28$326
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 11/165:45 pmMIA - STI
Nonstop2h 06mAmerican Airlines
dom. 11/236:20 amSTI - MIA
Nonstop2h 15mAmerican Airlines
Deal found 10/29$331

Cheapflights Fare Finder

 
Customize your flight search to find flights from Key Largo to Santiago de los Caballeros that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 30, 2025.
Use the filters below to find and compare flights from Key Largo to Santiago de los Caballeros that are best for you.

Fly from

Key Largo

Fly to

Santiago de los Caballeros

Route

Depart

Return

Price

MiamiSantiago de los Caballeros

MIA - STI

MIASTI

Miami

jue. 11/13

11:27 am-12:59 am

1 stop12h 32m

Santiago de los Caballeros

lun. 11/17

6:40 am-4:10 pm

1 stop10h 30m

$358

MiamiSantiago de los Caballeros

MIA - STI

MIASTI

Miami

jue. 11/6

3:27 pm-1:24 am

1 stop8h 57m

Santiago de los Caballeros

lun. 11/10

9:01 pm-10:30 am

1 stop14h 29m

$358

MiamiSantiago de los Caballeros

MIA - STI

MIASTI

Miami

mar. 11/11

6:00 am-7:36 pm

2 stops12h 36m

Santiago de los Caballeros

lun. 11/17

6:40 am-2:33 pm

1 stop8h 53m

$362

MiamiSantiago de los Caballeros

MIA - STI

MIASTI

Miami

mar. 11/18

11:27 am-12:59 am

1 stop12h 32m

Santiago de los Caballeros

sáb. 11/22

6:40 am-6:52 pm

1 stop13h 12m

$382

MiamiSantiago de los Caballeros

MIA - STI

MIASTI

Miami

mar. 11/4

6:00 am-8:06 pm

2 stops13h 06m

Santiago de los Caballeros

sáb. 11/8

7:00 am-11:19 pm

1 stop17h 19m

$385

MiamiSantiago de los Caballeros

MIA - STI

MIASTI

Miami

mar. 11/4

6:00 am-8:06 pm

2 stops13h 06m

Santiago de los Caballeros

mar. 11/11

6:40 am-6:51 pm

1 stop13h 11m

$385

MiamiSantiago de los Caballeros

MIA - STI

MIASTI

Miami

jue. 11/13

11:27 am-12:59 am

1 stop12h 32m

Santiago de los Caballeros

dom. 11/16

9:01 pm-10:30 am

1 stop14h 29m

$390

MiamiSantiago de los Caballeros

MIA - STI

MIASTI

Miami

sáb. 12/6

12:15 pm-3:32 pm

Nonstop2h 17m

$148

MiamiSantiago de los Caballeros

MIA - STI

MIASTI

Miami

lun. 11/24

3:42 pm-12:59 am

1 stop8h 17m

$167

MiamiSantiago de los Caballeros

MIA - STI

MIASTI

Miami

lun. 1/26

7:15 am-8:34 pm

2 stops12h 19m

$167

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/29

Showing 1-10 of 15 results
1
2

Best time to book a flight from Key Largo to Santiago de los Caballeros

Have a flexible travel schedule? Discover the best time to fly to Santiago de los Caballeros from Key Largo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key Largo to Santiago de los Caballeros

How far ahead should I book a flight from Key Largo to Santiago de los Caballeros?

Use this chart to determine the optimal time to book a round-trip flight from Key Largo to Santiago de los Caballeros. Price data was last updated on October 24, 2025.

The best time to book flights from Key Largo to Santiago de los Caballeros is 54 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Key Largo to Santiago de los Caballeros?

Currently, April is the cheapest month in which you can book a flight from Key Largo to Santiago de los Caballeros (average of $123). Flying from Key Largo to Santiago de los Caballeros in December is currently the most expensive (average of $170). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from KE9 to STI?

Find hourly flight availability from Key Largo to Santiago de los Caballeros. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated octubre 30, 2025.

It’s typically best to fly out from Key Largo to Santiago de los Caballeros in the evening. Doing so could potentially save you 18% on the flight price compared to flying at noon, which is usually more expensive.

What is the cheapest day to fly from Key Largo to Santiago de los Caballeros?

Use this chart to determine the cheapest time to fly round-trip from Key Largo to Santiago de los Caballeros. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Key Largo to Santiago de los Caballeros flight should consider departing on Friday afternoons when fares are most often at their lowest. Monday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Santiago de los Caballeros

Get insights into the airlines that provide service to Santiago de los Caballeros. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago de los Caballeros. Reviews last updated octubre 30, 2025.
Peruse reviews from past customers who have flown with Copa Airlines, American Airlines, and Spirit Airlines from Key Largo to Santiago de los Caballeros to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,561 reviews

Overall

7.6

Boarding

7.8

Entertainment

6.8

Crew

8.1

Comfort

7.4

Food

6.9

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Copa Airlines
7.6
Good
1,561 reviews
Copa Airlines
7.6
Good
1,561 reviews

Overall

7.6

Boarding

7.8

Entertainment

6.8

Crew

8.1

Comfort

7.4

Food

6.9

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
American Airlines
7.2
Good
11,035 reviews
Copa Airlines
7.6
Good
1,561 reviews

Overall

7.6

Boarding

7.8

Entertainment

6.8

Crew

8.1

Comfort

7.4

Food

6.9

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Spirit Airlines
6.3
Okay
8,116 reviews
Copa Airlines
7.6
Good
1,561 reviews

Overall

7.6

Boarding

7.8

Entertainment

6.8

Crew

8.1

Comfort

7.4

Food

6.9

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Frontier
5.8
Fair
3,122 reviews
Copa Airlines
7.6
Good
1,561 reviews

Overall

7.6

Boarding

7.8

Entertainment

6.8

Crew

8.1

Comfort

7.4

Food

6.9

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip

Related info for your journey

Find useful and relevant information for your journey from Key Largo to Santiago de los Caballeros. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santiago de los Caballeros from Key Largo?

    Most people fly into Santiago de los Caballeros (STI) if they book a flight to Santiago de los Caballeros from Key Largo. On average, Santiago has 0 inbound flights from Key Largo per day from 5 airlines. Santiago de los Caballeros is conveniently located just 6.8 mi from Santiago de los Caballeros’s city center.

  • How popular is this Key Largo to Santiago de los Caballeros flight route?

    Flights from Key Largo to Santiago de los Caballeros have been viewed 2 times in the past calendar month.

  • How long is the flight from Key Largo to Santiago de los Caballeros?

    A quick flight from Key Largo to Santiago de los Caballeros can take about 12h 32m. Delta provides one of the quickest options available for as low as $358. There are 758 mi between Key Largo and Santiago de los Caballeros.

  • What are the cheapest flights from Key Largo to Santiago de los Caballeros?

    On average you can expect to pay $342 for a flight from Key Largo to Santiago de los Caballeros. The cheapest flight overall is $196 while the most popular route, (Miami - Santiago de los Caballeros) is currently priced at $358.

  • Can I find deals for flights from Key Largo to Santiago de los Caballeros that include hotel bookings?

    Yes. In addition to deals on Key Largo to Santiago de los Caballeros flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key Largo to Santiago de los Caballeros?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key Largo to Santiago de los Caballeros.

  • Can I find deals for business class flights from Key Largo to Santiago de los Caballeros?

    Yes. Cheapflights offers flight deals from Key Largo to Santiago de los Caballeros by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Key Largo to Santiago de los Caballeros?

    Currently, April is the cheapest month in which you can book a flight from Key Largo to Santiago de los Caballeros (average of $123). Flying from Key Largo to Santiago de los Caballeros in December is currently the most expensive (average of $170). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Key Largo to Santiago de los Caballeros

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from Key Largo to Santiago de los Caballeros

Discover the top 5 airlines that operate flights from Key Largo to Santiago de los Caballeros. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$214Average$330FlexibilityNo cancel feeOn-time65%
FrontierCheapest$225Average$330FlexibilityNo cancel feeOn-time62%
American AirlinesCheapest$290Average$494FlexibilityNo cancel feeOn-time71%
JetBlueCheapest$305Average$527FlexibilityNo cancel feeOn-time62%
Copa AirlinesCheapest$337Average$426FlexibilityNo cancel feeOn-time70%

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