HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Santiago de los Caballeros

$152+ Cheap flights from Key Largo, FL to Santiago de los Caballeros (STI)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/25. Fares are subject to change and may not be available on all flights or dates of travel.
MIA — STI
Aug 4 — Aug 111
Mon 8/4
Mon 8/11
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Key Largo to Santiago de los Caballeros with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Key Largo to Santiago de los Caballeros are usually found in September or October, booked 85 days in advance, depart on a Thursday or Sunday and return on a Friday

Cheap flight deals from Key Largo to Santiago de los Caballeros

Keep the following information in mind while searching for Key Largo to Santiago de los Caballeros flight deals. Data was last updated July 30, 2025.

Round-trip from

$260
(American Airlines)

One-way from

$152
(SmartFares)

Popular in

December

Cheapest in

September

Average price

$495
From Key Largo to Santiago de los Caballeros
Search Deals
One-way flight from Key Largo to Santiago de los Caballeros
Search Deals
Highest demand for flights based on searches. 10% potential increase in price ($54 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($16 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2025
Search Deals

Find flight deals from Key Largo to Santiago de los Caballeros

Cheapest flights from Key Largo to Santiago de los Caballeros
Explore the most affordable flight options available from Key Largo to Santiago de los Caballeros. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 30, 2025.

This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1110:17 amMIA - STI
Nonstop2h 10mAmerican Airlines
Tue 9/161:29 pmSTI - MIA
Nonstop2h 16mAmerican Airlines
Deal found 7/29$260
This Flightnetwork deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flightnetwork is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/109:04 pmMIA - STI
1 stop15h 47mFrontier
Wed 8/132:10 pmSTI - MIA
1 stop8h 13mFrontier
Deal found 7/30$341
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/117:10 amMIA - STI
1 stop12h 01mDelta
Thu 9/188:40 pmSTI - MIA
1 stop14h 00mDelta
Deal found 7/28$355
This FlightHub deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/117:10 amMIA - STI
1 stop5h 49mMultiple Airlines
Sun 9/1412:10 pmSTI - MIA
2 stops29h 23mMultiple Airlines
Deal found 7/29$397
This Mytrip deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/276:50 amMIA - STI
2 stops26h 25mSpirit Airlines
Wed 9/310:20 amSTI - MIA
2 stops25h 33mSpirit Airlines
Deal found 7/28$404

Cheapflights Fare Finder

 
Customize your flight search to find flights from Key Largo to Santiago de los Caballeros that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 30, 2025.
Use the filters below to find and compare flights from Key Largo to Santiago de los Caballeros that are best for you.

Fly from

Key Largo

Fly to

Santiago de los Caballeros

Route

Depart

Return

Price

MiamiSantiago de los Caballeros

MIA - STI

MIASTI

Miami

Thu 9/11

10:17 am-12:27 pm

Nonstop2h 10m

Santiago de los Caballeros

Tue 9/16

1:29 pm-3:45 pm

Nonstop2h 16m

$260

MiamiSantiago de los Caballeros

MIA - STI

MIASTI

Miami

Sun 8/10

9:04 pm-12:51 pm

1 stop15h 47m

Santiago de los Caballeros

Wed 8/13

2:10 pm-10:23 pm

1 stop8h 13m

$341

MiamiSantiago de los Caballeros

MIA - STI

MIASTI

Miami

Thu 9/11

7:10 am-7:11 pm

1 stop12h 01m

Santiago de los Caballeros

Thu 9/18

8:40 pm-10:40 am

1 stop14h 00m

$355

MiamiSantiago de los Caballeros

MIA - STI

MIASTI

Miami

Thu 9/11

7:10 am-12:59 pm

1 stop5h 49m

Santiago de los Caballeros

Sun 9/14

12:10 pm-5:33 pm

2 stops29h 23m

$397

MiamiSantiago de los Caballeros

MIA - STI

MIASTI

Miami

Wed 8/27

6:50 am-9:15 am

2 stops26h 25m

Santiago de los Caballeros

Wed 9/3

10:20 am-11:53 am

2 stops25h 33m

$404

MiamiSantiago de los Caballeros

MIA - STI

MIASTI

Miami

Thu 9/25

7:10 am-12:59 pm

1 stop5h 49m

$152

MiamiSantiago de los Caballeros

MIA - STI

MIASTI

Miami

Fri 8/15

6:30 am-12:51 pm

1 stop6h 21m

$165

MiamiSantiago de los Caballeros

MIA - STI

MIASTI

Miami

Wed 8/20

7:00 am-9:15 am

2 stops26h 15m

$166

MiamiSantiago de los Caballeros

MIA - STI

MIASTI

Miami

Wed 8/13

10:11 am-12:31 pm

Nonstop2h 20m

$177

MiamiSantiago de los Caballeros

MIA - STI

MIASTI

Miami

Mon 9/29

3:15 pm-12:34 am

1 stop9h 19m

$182

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/29

Best time to book a flight from Key Largo to Santiago de los Caballeros

Have a flexible travel schedule? Discover the best time to fly to Santiago de los Caballeros from Key Largo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key Largo to Santiago de los Caballeros

How far ahead should I book a flight from Key Largo to Santiago de los Caballeros?

Use this chart to determine the optimal time to book a round-trip flight from Key Largo to Santiago de los Caballeros. Price data was last updated on July 25, 2025.

The best time to book flights from Key Largo to Santiago de los Caballeros is 85 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Key Largo to Santiago de los Caballeros?

Currently, May is the cheapest month in which you can book a flight from Key Largo to Santiago de los Caballeros (average of $347). Flying from Key Largo to Santiago de los Caballeros in July is currently the most expensive (average of $603). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from KE9 to STI?

Find hourly flight availability from Key Largo to Santiago de los Caballeros. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 30, 2025.

When flying from Key Largo to Santiago de los Caballeros, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

What is the cheapest day to fly from Key Largo to Santiago de los Caballeros?

Use this chart to determine the cheapest time to fly round-trip from Key Largo to Santiago de los Caballeros. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Key Largo to Santiago de los Caballeros flight should consider departing on Thursday at noon when fares are most often at their lowest. Wednesday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Key Largo to Santiago de los Caballeros

Explore weekly flight availability from Key Largo to Santiago de los Caballeros. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated July 30, 2025.

The most flights from KE9 to STI are scheduled on a Monday (3 on average). You will have fewer flight options on Saturday, which is when the least amount of flights are scheduled (2 on average).

Reviews of airlines servicing Santiago de los Caballeros

Get insights into the airlines that provide service to Santiago de los Caballeros. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago de los Caballeros. Reviews last updated July 30, 2025.
Peruse reviews from past customers who have flown with Delta, American Airlines, and Spirit Airlines from Key Largo to Santiago de los Caballeros to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,980 reviews

Food

7.3

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Crew

8.5

Overall

8.0

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
8.0
Very good
7,980 reviews
Delta
8.0
Very good
7,980 reviews

Food

7.3

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Crew

8.5

Overall

8.0

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,980 reviews

Food

7.3

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Crew

8.5

Overall

8.0

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Spirit Airlines
6.3
Okay
8,048 reviews
Delta
8.0
Very good
7,980 reviews

Food

7.3

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Crew

8.5

Overall

8.0

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Frontier
5.9
Fair
3,237 reviews
Delta
8.0
Very good
7,980 reviews

Food

7.3

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Crew

8.5

Overall

8.0

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Key Largo to Santiago de los Caballeros. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santiago de los Caballeros from Key Largo?

    Most people fly into Santiago de los Caballeros (STI) if they book a flight to Santiago de los Caballeros from Key Largo. On average, Santiago has 2 inbound flights from Key Largo per day from 5 airlines. Santiago de los Caballeros is conveniently located just 6.8 mi from Santiago de los Caballeros’s city center.

  • How popular is this Key Largo to Santiago de los Caballeros flight route?

    Flights from Key Largo to Santiago de los Caballeros have been viewed 2 times in the past calendar month.

  • What are the cheapest airlines to fly from Key Largo to Santiago de los Caballeros one-way?

    The cheapest airline one-way is Frontier, with whom users have recently found tickets for as low as $152. However, be on the lookout for offers from Spirit Airlines and American Airlines, as they are both options that can get you from Key Largo to Santiago de los Caballeros for a low price.

  • What are the cheapest flights from Key Largo to Santiago de los Caballeros?

    On average you can expect to pay $458 for a flight from Key Largo to Santiago de los Caballeros. The cheapest flight overall is $211 while the most popular route, (Miami - Santiago de los Caballeros) is currently priced at $345.

  • Can I find deals for flights from Key Largo to Santiago de los Caballeros that include hotel bookings?

    Yes. In addition to deals on Key Largo to Santiago de los Caballeros flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key Largo to Santiago de los Caballeros?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key Largo to Santiago de los Caballeros.

  • Can I find deals for business class flights from Key Largo to Santiago de los Caballeros?

    Yes. Cheapflights offers flight deals from Key Largo to Santiago de los Caballeros by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Key Largo to Santiago de los Caballeros?

    Currently, May is the cheapest month in which you can book a flight from Key Largo to Santiago de los Caballeros (average of $347). Flying from Key Largo to Santiago de los Caballeros in July is currently the most expensive (average of $603). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Key Largo to Santiago de los Caballeros

See prices for flight routes from nearby airports that may be better suited for you.
Miami to Punta Cana flights
Fort Lauderdale to Punta Cana flights
Orlando to Punta Cana flights
Miami to Santo Domingo flights
Orlando to Santo Domingo flights
Fort Lauderdale to Santo Domingo flights
Orlando to Santiago de los Caballeros flights
Miami to Santiago de los Caballeros flights
Tampa to Punta Cana flights
Fort Lauderdale to Santiago de los Caballeros flights
West Palm Beach to Punta Cana flights
Tampa to Santo Domingo flights
Miami to Puerto Plata flights
West Palm Beach to Santo Domingo flights
Tampa to Puerto Plata flights
Orlando to Puerto Plata flights
Jacksonville to Santo Domingo flights
Tampa to Santiago de los Caballeros flights
Jacksonville to Punta Cana flights
Miami to La Romana flights
Jacksonville to Puerto Plata flights
Jacksonville to Santiago de los Caballeros flights
Sarasota to Punta Cana flights
Fort Myers to Punta Cana flights
Pensacola to Punta Cana flights
Fort Lauderdale to Puerto Plata flights
West Palm Beach to Santiago de los Caballeros flights
Melbourne to Santo Domingo flights
Daytona Beach to Santo Domingo flights
Panama City to Punta Cana flights
Sarasota to Santo Domingo flights
Daytona Beach to Punta Cana flights
Tallahassee to Punta Cana flights
Pensacola to Santiago de los Caballeros flights
Melbourne to Punta Cana flights
Valparaiso to Punta Cana flights
Miami to Nagua flights
West Palm Beach to Puerto Plata flights
Fort Myers to Santo Domingo flights
Fort Myers to Santiago de los Caballeros flights
Gainesville to Punta Cana flights
Pensacola to Santo Domingo flights
Gainesville to Santiago de los Caballeros flights
Fort Myers to Puerto Plata flights
Daytona Beach to Santiago de los Caballeros flights
Valparaiso to Santiago de los Caballeros flights
Fort Lauderdale to Nagua flights
Daytona Beach to Puerto Plata flights

Top 5 airlines flying from Key Largo to Santiago de los Caballeros

Discover the top 5 airlines that operate flights from Key Largo to Santiago de los Caballeros. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$225Average$300FlexibilityNo cancel feeOn-time62%
Spirit AirlinesCheapest$236Average$344FlexibilityNo cancel feeOn-time65%
Copa AirlinesCheapest$303Average$343FlexibilityNo cancel feeOn-time70%
JetBlueCheapest$315Average$486FlexibilityNo cancel feeOn-time62%
American AirlinesCheapest$351Average$501FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.