What are the cheapest airlines to fly from Denver to Santiago de los Caballeros one-way?

To fly one-way, consider booking your trip with JetBlue, which is currently one of the cheapest options available, starting at $249. Frontier flights start at $265 while deals on Delta start at $270 one-way.

What is the cheapest day to fly from Denver to Santiago de los Caballeros?

Travelers seeking maximum savings on their Denver to Santiago de los Caballeros flight should consider departing on Monday evenings when fares are most often at their lowest. Friday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

In terms of precipitation, rainfall in Santiago de los Caballeros ranges from 3.0 - 11.6 inches per month. December is typically the wettest month, when rainfall can reach 11.6 in. July is typically the driest time to visit Santiago de los Caballeros when rainfall is around 3.0 in.

If weather is an important factor for your trip to Santiago de los Caballeros, use this chart to help with planning. For those seeking warmer temperatures, June is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 73.4 F).

What are the most popular airlines that fly from Denver to Santiago de los Caballeros?

The most popular airlines flying from Denver to Santiago de los Caballeros are American Airlines, JetBlue and Delta. Something to consider prior to booking your flight.

What is the cheapest day to fly round-trip from Denver to Santiago de los Caballeros?

Monday is generally a great day to depart. Flying on this day could help you save up to 29%.

What is the cheapest month to fly from Denver to Santiago de los Caballeros?

February can be a great time to fly to Santiago de los Caballeros from Denver with a flight ticket averaging about $660. Cheapflights users have found deals in the month of February for as cheap as $302. The most expensive prices can be found in the month of December.

How can I find direct flights from Denver to Santiago de los Caballeros?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Denver to Santiago de los Caballeros.

Can I find deals for business class flights from Denver to Santiago de los Caballeros?

Yes. Cheapflights offers flight deals from Denver to Santiago de los Caballeros by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$220+ Flights from Denver to Santiago de los Caballeros

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Cheap flight deals from Denver to Santiago de los Caballeros

Round-trip from	$457 (JetBlue)
One-way from	$220 (Mytrip)
Popular in	December
Cheapest in	February
Average price	$615

From Denver Intl to Santiago de los Caballeros

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One-way flight from Denver Intl to Santiago de los Caballeros

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Highest demand for flights based on searches. 21% potential increase in price ($184 potential increase over avg. RT price).

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Cheapest flight prices on average. 4% potential price decrease ($29 potential savings vs. average RT price).

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Average for round-trip flights in July 2025

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Find flight deals from Denver to Santiago de los Caballeros

Cheapest flights from Denver to Santiago de los Caballeros
Explore the most affordable flight options available from Denver to Santiago de los Caballeros. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julio 29, 2025.

mié. 10/111:59 pmDEN - STI

1 stop8h 55mJetBlue

lun. 10/69:55 amSTI - DEN

1 stop15h 09mJetBlue

Deal found 7/29

$457

jue. 8/148:52 amDEN - STI

2 stops25h 59mFrontier

jue. 8/211:26 pmSTI - DEN

2 stops29h 15mFrontier

Deal found 7/29

$506

mar. 9/1611:57 pmDEN - STI

1 stop10h 30mAmerican Airlines

mar. 10/71:14 pmSTI - DEN

1 stop11h 42mAmerican Airlines

Deal found 7/28

$555

mar. 9/166:25 pmDEN - STI

2 stops16h 15mDelta

mar. 10/78:31 pmSTI - DEN

2 stops17h 16mDelta

Deal found 7/29

$559

jue. 8/145:50 pmDEN - STI

3 stops37h 25mMultiple Airlines

jue. 8/2110:20 amSTI - DEN

3 stops33h 05mMultiple Airlines

Deal found 7/29

$770

Best flights from Denver to Santiago de los Caballeros
Discover carefully curated flight deals from Denver to Santiago de los Caballeros that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated julio 29, 2025.

mié. 10/111:59 pmDEN - STI

1 stop8h 55mJetBlue

lun. 10/69:55 amSTI - DEN

1 stop15h 09mJetBlue

Deal found 7/29

$457

jue. 8/148:52 amDEN - STI

2 stops25h 59mFrontier

jue. 8/211:26 pmSTI - DEN

2 stops29h 15mFrontier

Deal found 7/29

$506

mar. 9/1611:57 pmDEN - STI

1 stop10h 30mAmerican Airlines

mar. 10/71:14 pmSTI - DEN

1 stop11h 42mAmerican Airlines

Deal found 7/28

$555

mar. 9/164:49 pmDEN - STI

2 stops17h 51mDelta

mar. 10/76:00 amSTI - DEN

1 stop14h 19mDelta

Deal found 7/29

$559

jue. 8/145:50 pmDEN - STI

3 stops37h 25mMultiple Airlines

jue. 8/2110:20 amSTI - DEN

3 stops33h 05mMultiple Airlines

Deal found 7/29

$770

Last-minute flights from Denver to Santiago de los Caballeros
Discover last-minute flight deals from Denver to Santiago de los Caballeros. Data last updated julio 29, 2025 and is based on user searches.

mié. 7/3012:55 amDEN - STI

2 stops16h 33mDelta

jue. 8/76:03 amSTI - DEN

2 stops18h 26mDelta

Deal found 7/28

$996

mar. 8/512:55 amDEN - STI

2 stops16h 33mDelta

vie. 8/156:03 amSTI - DEN

2 stops20h 12mDelta

Deal found 7/28

$1,169

mié. 8/61:39 pmDEN - STI

2 stops45h 12mFrontier

vie. 8/152:06 pmSTI - DEN

2 stops35h 05mFrontier

Deal found 7/28

$657

mié. 8/611:52 pmDEN - STI

1 stop10h 39mAmerican Airlines

vie. 8/151:31 pmSTI - DEN

1 stop11h 28mAmerican Airlines

Deal found 7/28

$668

mié. 8/611:54 pmDEN - STI

1 stop11h 38mJetBlue

jue. 8/142:15 amSTI - DEN

1 stop10h 10mJetBlue

Deal found 7/28

$857

mié. 8/611:25 amDEN - STI

2 stops30h 40mMultiple Airlines

vie. 8/1510:20 amSTI - DEN

3 stops32h 41mMultiple Airlines

Deal found 7/28

$1,708

jue. 8/148:52 amDEN - STI

2 stops25h 59mFrontier

jue. 8/211:26 pmSTI - DEN

2 stops29h 15mFrontier

Deal found 7/29

$506

jue. 8/1411:52 pmDEN - STI

1 stop10h 39mAmerican Airlines

jue. 8/211:31 pmSTI - DEN

1 stop11h 28mAmerican Airlines

Deal found 7/29

$563

jue. 8/1411:54 pmDEN - STI

1 stop11h 38mJetBlue

mié. 8/202:17 amSTI - DEN

1 stop22h 42mJetBlue

Deal found 7/29

$746

jue. 8/145:50 pmDEN - STI

3 stops37h 25mMultiple Airlines

jue. 8/2110:20 amSTI - DEN

3 stops33h 05mMultiple Airlines

Deal found 7/29

$770

One-way flights from Denver to Santiago de los Caballeros
Search for one-way flight options from Denver to Santiago de los Caballeros. Find affordable one-way fares based on user searches. Data last updated julio 29, 2025.

vie. 9/268:40 amDEN - STI

2 stops24h 25mMultiple Airlines

Deal found 7/28

$220

vie. 9/2611:59 pmDEN - STI

1 stop9h 05mJetBlue

Deal found 7/28

$249

jue. 8/78:52 amDEN - STI

2 stops25h 59mFrontier

Deal found 7/27

$265

jue. 8/2812:11 pmDEN - STI

1 stop10h 31mDelta

Deal found 7/29

$270

vie. 9/262:47 pmDEN - STI

2 stops19h 40mAmerican Airlines

Deal found 7/28

$276

jue. 8/79:40 amDEN - STI

3 stops14h 06mUnited Airlines

Deal found 7/28

$2,061

Cheapflights Fare Finder

Use the filters below to find and compare flights from Denver to Santiago de los Caballeros that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DenverSantiago de los Caballeros

DEN - STI

DENSTI

Denver Intl

mié. 10/1

11:59 pm-10:54 am

1 stop8h 55m

Santiago de los Caballeros

lun. 10/6

9:55 am-11:04 pm

1 stop15h 09m

$457

DenverSantiago de los Caballeros

DEN - STI

DENSTI

Denver Intl

jue. 8/14

8:52 am-12:51 pm

2 stops25h 59m

Santiago de los Caballeros

jue. 8/21

1:26 pm-4:41 pm

2 stops29h 15m

$506

DenverSantiago de los Caballeros

DEN - STI

DENSTI

Denver Intl

mar. 9/16

11:57 pm-12:27 pm

1 stop10h 30m

Santiago de los Caballeros

mar. 10/7

1:14 pm-10:56 pm

1 stop11h 42m

$555

DenverSantiago de los Caballeros

DEN - STI

DENSTI

Denver Intl

mar. 9/16

4:49 pm-12:40 pm

2 stops17h 51m

Santiago de los Caballeros

mar. 10/7

6:00 am-6:19 pm

1 stop14h 19m

$559

DenverSantiago de los Caballeros

DEN - STI

DENSTI

Denver Intl

jue. 8/14

5:50 pm-9:15 am

3 stops37h 25m

Santiago de los Caballeros

jue. 8/21

10:20 am-5:25 pm

3 stops33h 05m

$770

DenverSantiago de los Caballeros

DEN - STI

DENSTI

Denver Intl

vie. 9/26

8:40 am-11:05 am

2 stops24h 25m

$220

DenverSantiago de los Caballeros

DEN - STI

DENSTI

Denver Intl

vie. 9/26

11:59 pm-11:04 am

1 stop9h 05m

$249

DenverSantiago de los Caballeros

DEN - STI

DENSTI

Denver Intl

jue. 8/7

8:52 am-12:51 pm

2 stops25h 59m

$265

DenverSantiago de los Caballeros

DEN - STI

DENSTI

Denver Intl

jue. 8/28

12:11 pm-12:42 am

1 stop10h 31m

$270

DenverSantiago de los Caballeros

DEN - STI

DENSTI

Denver Intl

vie. 9/26

2:47 pm-12:27 pm

2 stops19h 40m

$276

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/28

Showing 1-10 of 11 results

Best time to book a flight from Denver to Santiago de los Caballeros

Have a flexible travel schedule? Discover the best time to fly to Santiago de los Caballeros from Denver with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Denver to Santiago de los Caballeros

What is the cheapest month to book a flight from Denver to Santiago de los Caballeros?

Currently, May is the cheapest month in which you can book a flight from Denver to Santiago de los Caballeros (average of $347). Flying from Denver to Santiago de los Caballeros in July is currently the most expensive (average of $612). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DEN to STI?

A simple way to save on the total cost of your ticket is to fly from Denver to Santiago de los Caballeros in the morning. If you’re flexible enough to do this you can expect to save up to 10% on your trip compared to booking a flight at noon.

Reviews of airlines servicing Santiago de los Caballeros

Read through reviews of airlines operating flights from Denver to Santiago de los Caballeros, such as Delta, United Airlines, and JetBlue. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,977 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Delta

8.0

Very good

7,977 reviews

Delta

8.0

Very good

7,977 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

United Airlines

7.4

Good

8,899 reviews

Delta

8.0

Very good

7,977 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

JetBlue

7.3

Good

2,913 reviews

Delta

8.0

Very good

7,977 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,977 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Frontier

5.9

Fair

3,238 reviews

Delta

8.0

Very good

7,977 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

What are the cheapest airlines flying from Denver to Santiago de los Caballeros round-trip?
Our cheapest airline available from Denver to Santiago de los Caballeros is JetBlue. Our recent data shows that you can find tickets from as low as $457 on this airline. Additional options worth looking into are Frontier and American Airlines, starting at $506 and $555 round-trip. Users have found that JetBlue is 30% cheaper than the other options available to this destination.
What are the cheapest airlines to fly from Denver to Santiago de los Caballeros one-way?
To fly one-way, consider booking your trip with JetBlue, which is currently one of the cheapest options available, starting at $249. Frontier flights start at $265 while deals on Delta start at $270 one-way.
Can I find deals for flights from Denver to Santiago de los Caballeros that include hotel bookings?
Yes. In addition to deals on Denver to Santiago de los Caballeros flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Denver to Santiago de los Caballeros?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Denver to Santiago de los Caballeros.
Can I find deals for business class flights from Denver to Santiago de los Caballeros?
Yes. Cheapflights offers flight deals from Denver to Santiago de los Caballeros by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Denver to Santiago de los Caballeros?
Currently, May is the cheapest month in which you can book a flight from Denver to Santiago de los Caballeros (average of $347). Flying from Denver to Santiago de los Caballeros in July is currently the most expensive (average of $612). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Top 3 airlines flying from Denver to Santiago de los Caballeros

Airline	Cheapest	Average	Flexibility	On-time
JetBlue	Cheapest$296	Average$555	FlexibilityNo cancel fee	On-time62%
Delta	Cheapest$485	Average$582	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$495	Average$685	FlexibilityNo cancel fee	On-time71%

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$220+ Cheap flights from Denver (DEN) to Santiago de los Caballeros (STI)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/26. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Denver to Santiago de los Caballeros with Cheapflights

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2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Denver to Santiago de los Caballeros

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Denver to Santiago de los Caballeros

Cheapest flights from Denver to Santiago de los CaballerosExplore the most affordable flight options available from Denver to Santiago de los Caballeros. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julio 29, 2025.

Explore the most affordable flight options available from Denver to Santiago de los Caballeros. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julio 29, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Denver to Santiago de los Caballeros that are best for you.

Best time to book a flight from Denver to Santiago de los Caballeros

Have a flexible travel schedule? Discover the best time to fly to Santiago de los Caballeros from Denver with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Denver to Santiago de los Caballeros

What is the cheapest month to book a flight from Denver to Santiago de los Caballeros?

What is the cheapest time of day to fly from DEN to STI?

Find hourly flight availability from Denver to Santiago de los Caballeros. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated julio 29, 2025.

Reviews of airlines servicing Santiago de los Caballeros

Read through reviews of airlines operating flights from Denver to Santiago de los Caballeros, such as Delta, United Airlines, and JetBlue. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Denver to Santiago de los Caballeros. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from Denver to Santiago de los Caballeros round-trip?

What are the cheapest airlines to fly from Denver to Santiago de los Caballeros one-way?

Can I find deals for flights from Denver to Santiago de los Caballeros that include hotel bookings?

How can I find direct flights from Denver to Santiago de los Caballeros?

Can I find deals for business class flights from Denver to Santiago de los Caballeros?

What is the cheapest month to book a flight from Denver to Santiago de los Caballeros?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Denver to Santiago de los Caballeros

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from Denver to Santiago de los Caballeros

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Cheapest flights from Denver to Santiago de los Caballeros
Explore the most affordable flight options available from Denver to Santiago de los Caballeros. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julio 29, 2025.