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$326+ Cheap flights from St. Louis (STL) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/8. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SCL
Jun 17 — Jun 241
Tue 6/17
Tue 6/24
1 adult, Economy
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Cheapflights Tip: The best prices from Lambert-St Louis to Santiago Arturo Merino Benitez are usually found in October or July, booked 49 days in advance, depart on a Wednesday or Monday and return on a Tuesday

Cheap flight deals from St. Louis to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 12, 2025.

Round-trip from

$843
(SmartFares)

One-way from

$326
(Kiwi.com)

Popular in

December

Cheapest in

October

Average price

$1,019
From Lambert-St Louis to Santiago Arturo Merino Benitez
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One-way flight from Lambert-St Louis to Santiago Arturo Merino Benitez
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Highest demand for flights based on searches. 5% potential increase in price ($58 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($20 potential savings vs. average RT price).
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Average for round-trip flights in June 2025
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Find flight deals from St. Louis to Santiago

Cheapest flights from St. Louis to Santiago
Explore the most affordable flight options available from St. Louis to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

This SmartFares deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/109:00 amSTL - SCL
1 stop19h 00mLATAM Airlines
Sun 11/232:30 pmSCL - STL
2 stops36h 09mLATAM Airlines
Deal found 6/11$843
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/102:40 pmSTL - SCL
2 stops15h 25mAmerican Airlines
Sun 11/2310:15 pmSCL - STL
2 stops16h 42mAmerican Airlines
Deal found 6/10$848
This LATAM Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/188:25 amSTL - SCL
3 stops32h 10mMultiple Airlines
Mon 8/253:40 pmSCL - STL
2 stops31h 22mMultiple Airlines
Deal found 6/11$874
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/13:30 pmSTL - SCL
1 stop13h 30mDelta
Fri 11/2112:30 amSCL - STL
2 stops20h 32mDelta
Deal found 6/10$884
This Copa Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/267:55 amSTL - SCL
2 stops20h 09mCopa Airlines
Fri 8/112:23 amSCL - STL
2 stops20h 08mCopa Airlines
Deal found 6/10$1,946

Cheapflights Fare Finder

Customize your flight search to find flights from St. Louis to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
Use the filters below to find and compare flights from St. Louis to Santiago that are best for you.

Fly from

St. Louis

Fly to

Santiago

Route

Depart

Return

Price

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Mon 11/10

9:00 am-7:00 am

1 stop19h 00m

Santiago Arturo Merino Benitez

Sun 11/23

2:30 pm-11:39 pm

2 stops36h 09m

$843

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Mon 11/10

2:40 pm-9:05 am

2 stops15h 25m

Santiago Arturo Merino Benitez

Sun 11/23

10:15 pm-11:57 am

2 stops16h 42m

$848

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Mon 8/18

8:25 am-5:35 pm

3 stops32h 10m

Santiago Arturo Merino Benitez

Mon 8/25

3:40 pm-10:02 pm

2 stops31h 22m

$874

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Sat 11/1

3:30 pm-7:00 am

1 stop13h 30m

Santiago Arturo Merino Benitez

Fri 11/21

12:30 am-6:02 pm

2 stops20h 32m

$884

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Sat 7/26

7:55 am-5:04 am

2 stops20h 09m

Santiago Arturo Merino Benitez

Fri 8/1

12:23 am-7:31 pm

2 stops20h 08m

$1,946

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Tue 7/8

5:40 pm-10:30 pm

3 stops51h 50m

$326

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Tue 7/15

1:29 pm-6:30 am

2 stops16h 01m

$537

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Tue 7/15

9:27 am-7:00 am

1 stop20h 33m

$543

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Thu 6/26

5:25 am-7:00 am

1 stop24h 35m

$683

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Sun 6/22

8:10 am-7:50 am

3 stops46h 40m

$2,055

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/11

Best time to book a flight from St. Louis to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Santiago

How far ahead should I book a flight from St. Louis to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from St. Louis to Santiago. Price data was last updated on June 9, 2025.

To ensure you get the cheapest price possible for a flight from St. Louis to Santiago, you should look to book at least 49 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from St. Louis to Santiago?

Currently, April is the cheapest month in which you can book a flight from St. Louis to Santiago (average of $752). Flying from St. Louis to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from STL to SCL?

Find hourly flight availability from St. Louis to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 12, 2025.

A simple way to save on the total cost of your ticket is to fly from St. Louis to Santiago at noon. If you’re flexible enough to do this you can expect to save up to 9% on your trip compared to booking a flight in the morning.

Rainfall in Santiago by month

Plan your trip to Santiago by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Santiago ranges from 0.0 - 2.8 inches per month. June is typically the wettest month, when rainfall can reach 2.8 in. January is typically the driest time to visit Santiago when rainfall is around 0.0 in.

Temperature in Santiago by month

Plan your trip to Santiago by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Santiago, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 69.8 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 46.4 F).

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated June 12, 2025.
Delta
8.0
Very good
7,946 reviews

Crew

8.5

Overall

8.0

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,946 reviews
Delta
8.0
Very good
7,946 reviews

Crew

8.5

Overall

8.0

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
LATAM Airlines
7.5
Good
1,785 reviews
Delta
8.0
Very good
7,946 reviews

Crew

8.5

Overall

8.0

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Copa Airlines
7.5
Good
1,451 reviews
Delta
8.0
Very good
7,946 reviews

Crew

8.5

Overall

8.0

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Turkish Airlines
7.3
Good
3,848 reviews
Delta
8.0
Very good
7,946 reviews

Crew

8.5

Overall

8.0

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,946 reviews

Crew

8.5

Overall

8.0

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from St. Louis to Santiago round-trip?

    Flying on LATAM Airlines is currently your cheapest option to Santiago, with prices starting at $843. Additional round-trip tickets that might be worth considering are offered by American Airlines and Delta, with the lowest prices starting at $848 and $884, respectively. These flights start at 13% lower than the current average price 3 months from now.

  • What are the cheapest airlines to fly from St. Louis to Santiago one-way?

    The cheapest airline one-way is LATAM Airlines, with whom users have recently found tickets for as low as $537. However, be on the lookout for offers from Delta and American Airlines, as they are both options that can get you from St. Louis to Santiago for a low price.

  • Can I find deals for flights from St. Louis to Santiago that include hotel bookings?

    Yes. In addition to deals on St. Louis to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Santiago.

  • Can I find deals for business class flights from St. Louis to Santiago?

    Yes. Cheapflights offers flight deals from St. Louis to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from St. Louis to Santiago?

    Currently, April is the cheapest month in which you can book a flight from St. Louis to Santiago (average of $752). Flying from St. Louis to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for St. Louis to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from St. Louis to Santiago

Discover the top 4 airlines that operate flights from St. Louis to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$742Average$1,026FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$762Average$986FlexibilityNo cancel feeOn-time81%
American AirlinesCheapest$822Average$992FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$883Average$1,002FlexibilityNo cancel feeOn-time69%

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