$275+ Cheap flights from St. Louis (STL) to Santiago (SCL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/21. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SCL
Aug 19 — Aug 261
Round-trip
1 adult, Economy
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Find cheap flights from St. Louis to Santiago with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from St. Louis to Santiago
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Best
Last-minute
One-way
Cheapest flights from St. Louis to SantiagoExplore the most affordable flight options available from St. Louis to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 20, 2026.
Explore the most affordable flight options available from St. Louis to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 20, 2026.
This American Airlines deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/35:00 am
STL
- SCL
1 stop25h 05m
American Airlines
Wed 9/169:30 pm
SCL
- STL
1 stop17h 51m
American Airlines
Deal found 7/19![American Airlines logo]()
$996
This American Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/111:35 am
STL
- SCL
1 stop17h 50m
American Airlines
Sun 9/69:50 pm
SCL
- STL
1 stop14h 55m
American Airlines
Deal found 7/15![American Airlines logo]()
$997
This American Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/212:45 pm
STL
- SCL
2 stops17h 20m
American Airlines
Mon 9/79:50 pm
SCL
- STL
2 stops21h 00m
American Airlines
Deal found 7/15![American Airlines logo]()
$1,002
This LATAM Airlines deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2812:00 pm
STL
- SCL
2 stops16h 55m
LATAM Airlines
Sun 11/18:30 pm
SCL
- STL
2 stops23h 36m
LATAM Airlines
Deal found 7/19![LATAM Airlines logo]()
$1,007
This LATAM Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/212:52 pm
STL
- SCL
3 stops23h 33m
LATAM Airlines
Sun 9/612:05 am
SCL
- STL
2 stops19h 48m
LATAM Airlines
Deal found 7/15![LATAM Airlines logo]()
$1,012
This United Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/282:56 pm
STL
- SCL
1 stop14h 54m
United Airlines
Sun 11/110:45 pm
SCL
- STL
1 stop22h 40m
United Airlines
Deal found 7/15![United Airlines logo]()
$1,027
This oojo deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/277:20 pm
STL
- SCL
2 stops17h 40m
LATAM Airlines
Tue 11/248:30 am
SCL
- STL
3 stops35h 36m
LATAM Airlines
Deal found 7/15![LATAM Airlines logo]()
$1,036
This Delta deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/226:00 am
STL
- SCL
1 stop22h 40m
Delta
Fri 1/18:13 am
SCL
- STL
2 stops18h 26m
Delta
Deal found 7/19![Delta logo]()
$1,047
This LATAM Airlines deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/85:28 pm
STL
- SCL
2 stops33h 07m
LATAM Airlines
Sat 11/145:55 pm
SCL
- STL
2 stops26h 11m
LATAM Airlines
Deal found 7/18![LATAM Airlines logo]()
$1,059
This oojo deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/109:00 am
STL
- SCL
2 stops18h 55m
LATAM Airlines
Sat 12/198:25 am
SCL
- STL
3 stops29h 23m
LATAM Airlines
Deal found 7/17![LATAM Airlines logo]()
$1,065
Best flights from St. Louis to SantiagoDiscover carefully curated flight deals from St. Louis to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 20, 2026.
Discover carefully curated flight deals from St. Louis to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 20, 2026.
This United Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/268:35 am
STL
- SCL
1 stop21h 15m
United Airlines
Mon 11/1610:45 pm
SCL
- STL
1 stop18h 28m
United Airlines
Deal found 7/15![United Airlines logo]()
$997
This American Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/211:35 am
STL
- SCL
1 stop18h 30m
American Airlines
Mon 9/79:50 pm
SCL
- STL
1 stop14h 49m
American Airlines
Deal found 7/15![American Airlines logo]()
$997
This LATAM Airlines deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2812:00 pm
STL
- SCL
2 stops16h 55m
LATAM Airlines
Sun 11/18:30 pm
SCL
- STL
2 stops23h 36m
LATAM Airlines
Deal found 7/19![LATAM Airlines logo]()
$1,007
This Delta deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/226:00 am
STL
- SCL
1 stop22h 40m
Delta
Mon 1/412:48 am
SCL
- STL
2 stops25h 51m
Delta
Deal found 7/19![Delta logo]()
$1,007
This American Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/19:32 am
STL
- SCL
2 stops19h 53m
American Airlines
Sun 9/69:50 pm
SCL
- STL
2 stops21h 11m
American Airlines
Deal found 7/15![American Airlines logo]()
$1,002
This United Airlines deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2811:00 am
STL
- SCL
1 stop18h 50m
United Airlines
Sun 11/110:45 pm
SCL
- STL
1 stop22h 40m
United Airlines
Deal found 7/19![United Airlines logo]()
$1,027
Last-minute flights from St. Louis to SantiagoDiscover last-minute flight deals from St. Louis to Santiago. Data last updated July 20, 2026 and is based on user searches.
Discover last-minute flight deals from St. Louis to Santiago. Data last updated July 20, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/196:14 am
STL
- SCL
2 stops15h 29m
United Airlines
Tue 7/2811:22 am
SCL
- STL
2 stops25h 19m
United Airlines
Deal found 7/17![United Airlines logo]()
$1,210
This United Airlines deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/196:14 am
STL
- SCL
2 stops15h 29m
United Airlines
Sat 8/14:14 am
SCL
- STL
2 stops30h 53m
United Airlines
Deal found 7/17![United Airlines logo]()
$1,240
This United Airlines deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/196:14 am
STL
- SCL
2 stops16h 12m
United Airlines
Fri 7/3111:22 am
SCL
- STL
2 stops37h 22m
United Airlines
Deal found 7/17![United Airlines logo]()
$1,251
This LATAM Airlines deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/2010:51 am
STL
- SCL
2 stops18h 09m
LATAM Airlines
Wed 7/298:40 pm
SCL
- STL
1 stop22h 13m
LATAM Airlines
Deal found 7/17![LATAM Airlines logo]()
$1,194
This LATAM Airlines deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/2010:51 am
STL
- SCL
2 stops18h 09m
LATAM Airlines
Thu 7/3011:00 pm
SCL
- STL
2 stops25h 53m
LATAM Airlines
Deal found 7/17![LATAM Airlines logo]()
$1,199
This KAYAK deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/2010:51 am
STL
- SCL
2 stops18h 09m
LATAM Airlines
Sun 8/28:40 pm
SCL
- STL
1 stop14h 14m
LATAM Airlines
Deal found 7/17![LATAM Airlines logo]()
$1,224
This KAYAK deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/2010:51 am
STL
- SCL
2 stops18h 09m
LATAM Airlines
Sat 8/111:00 pm
SCL
- STL
2 stops19h 53m
LATAM Airlines
Deal found 7/17![LATAM Airlines logo]()
$1,229
This United Airlines deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/226:14 am
STL
- SCL
2 stops19h 46m
United Airlines
Tue 7/2812:43 am
SCL
- STL
2 stops23h 02m
United Airlines
Deal found 7/17![United Airlines logo]()
$1,180
This KAYAK deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/226:14 am
STL
- SCL
2 stops19h 46m
Copa Airlines
Thu 7/3012:43 am
SCL
- STL
2 stops24h 01m
Copa Airlines
Deal found 7/17![Copa Airlines logo]()
$1,193
This KAYAK deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/2311:10 am
STL
- SCL
2 stops17h 04m
Copa Airlines
Wed 7/292:14 am
SCL
- STL
2 stops22h 30m
Copa Airlines
Deal found 7/18![Copa Airlines logo]()
$1,165
This Delta deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/810:31 am
STL
- SCL
2 stops18h 24m
Delta
Fri 8/148:40 pm
SCL
- STL
1 stop18h 53m
Delta
Deal found 7/16![Delta logo]()
$1,067
This oojo deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/86:00 am
STL
- SCL
2 stops22h 55m
LATAM Airlines
Fri 8/148:40 am
SCL
- STL
3 stops28h 16m
LATAM Airlines
Deal found 7/15![LATAM Airlines logo]()
$1,096
One-way flights from St. Louis to SantiagoSearch for one-way flight options from St. Louis to Santiago. Find affordable one-way fares based on user searches. Data last updated July 20, 2026.
Search for one-way flight options from St. Louis to Santiago. Find affordable one-way fares based on user searches. Data last updated July 20, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2110:35 am
STL
- SCL
3 stops41h 35m
Multiple Airlines
Deal found 7/16![Multiple Airlines logo]()
$275
This American Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/2411:35 am
STL
- SCL
1 stop18h 30m
American Airlines
Deal found 7/15![American Airlines logo]()
$658
This LATAM Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/2411:00 am
STL
- SCL
3 stops25h 25m
LATAM Airlines
Deal found 7/15![LATAM Airlines logo]()
$663
Find flight deals from St. Louis to Santiago
Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 20, 2026.
Most accurate provider | Ovago 3 stars |
|---|---|
Most trusted provider | Ovago 3 stars |
Round-trip from | $996 (American Airlines) |
One-way from | $275 (Kiwi.com) |
Popular in | January |
Cheapest in | March |
Average price | $1,055 |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 20, 2026.
Use the filters below to find and compare flights from St. Louis to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Mon 10/26
8:35 am-7:50 am
1 stop21h 15m
Santiago Arturo Merino Benitez
Mon 11/16
10:45 pm-2:13 pm
1 stop18h 28m
$997
Quickest round-trip
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Wed 9/2
11:35 am-7:05 am
1 stop18h 30m
Santiago Arturo Merino Benitez
Mon 9/7
9:50 pm-10:39 am
1 stop14h 49m
$997
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Tue 9/1
9:32 am-6:25 am
2 stops19h 53m
Santiago Arturo Merino Benitez
Sun 9/6
9:50 pm-5:01 pm
2 stops21h 11m
$1,002
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Wed 10/28
12:00 pm-6:55 am
2 stops16h 55m
Santiago Arturo Merino Benitez
Sun 11/1
8:30 pm-5:06 pm
2 stops23h 36m
$1,007
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Tue 12/22
6:00 am-7:40 am
1 stop22h 40m
Santiago Arturo Merino Benitez
Mon 1/4
12:48 am-11:39 pm
2 stops25h 51m
$1,007
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Wed 10/28
11:00 am-7:50 am
1 stop18h 50m
Santiago Arturo Merino Benitez
Sun 11/1
10:45 pm-6:25 pm
1 stop22h 40m
$1,027
Cheapest one-way
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Wed 10/21
10:35 am-6:10 am
3 stops41h 35m
$275
Quickest one-way
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Mon 8/24
12:55 pm-7:05 am
2 stops17h 10m
$658
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Mon 8/24
11:00 am-1:25 pm
3 stops25h 25m
$663
Sorted by cheapest first
Compare providers for flights from St. Louis to Santiago
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Santiago in July.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on St. Louis-Santiago flights, users find the pricing of Ovago to be most consistent on Cheapflights vs. Ovago Users can find the same prices on St. Louis-Santiago flight deals on Cheapflights vs. Ovago >95% of the time. Price accuracy is based on data collected from St. Louis-Santiago flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on St. Louis-Santiago flights, Cheapflights users trust Ovago the most. Ovago has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from St. Louis to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from St. Louis with our price prediction graph.
STL-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to Santiago
What is the cheapest month to book a flight from St. Louis to Santiago?
Currently, March is the cheapest month in which you can book a flight from St. Louis to Santiago (average of $823). Flying from St. Louis to Santiago in January is currently the most expensive (average of $1,948). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from St. Louis to Santiago?
Reviews of airlines servicing Santiago
Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated July 20, 2026.
Peruse reviews from past customers who have flown with Delta,LATAM Airlines, andAmerican Airlines from St. Louis to Santiago to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.8
Food
7.2
Overall
7.8
Boarding
8.1
Crew
8.5
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Comfort
7.8
Food
7.2
Overall
7.8
Boarding
8.1
Crew
8.5
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Comfort
7.8
Food
7.2
Overall
7.8
Boarding
8.1
Crew
8.5
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Comfort
7.8
Food
7.2
Overall
7.8
Boarding
8.1
Crew
8.5
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from St. Louis to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Complete your trip
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Popular flights
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Alternative routes for St. Louis to Santiago
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Complete your trip
Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from St. Louis to Santiago by cabin class
Find flights from St. Louis to Santiago, based on your preferred cabin class, be it economy, premium economy, business, or first class.
St. Louis and Santiago flights
Browse other St. Louis and Santiago flight options. Last updated on July 20, 2026.
Other flights from St. Louis
Browse through other flights departing from St. Louis. Flights are based on user searches made on Cheapflights and were last updated on July 20, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on July 20, 2026.
Top 3 airlines flying from St. Louis to Santiago
Discover the top 3 airlines that operate flights from St. Louis to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 20, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$611 | Average$1,125 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$689 | Average$894 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$792 | Average$1,013 | FlexibilityNo cancel fee | On-time81% |