$359+ Cheap flights from St. Louis (STL) to Santiago (SCL)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/30. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SCL
Dec 7 — Dec 141
Round-trip
1 adult, Economy
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Find cheap flights from St. Louis to Santiago with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from St. Louis to Santiago
Cheapest
Best
Last-minute
One-way
Cheapest flights from St. Louis to SantiagoExplore the most affordable flight options available from St. Louis to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 7, 2026.
Explore the most affordable flight options available from St. Louis to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 7, 2026.
This Mytrip deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/253:04 pm -
3 stops35h 41m
Wed 12/94:15 pm -
2 stops34h 57m
Deal found 11/4![Multiple Airlines logo]()
$742
This FlightHub deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/223:48 pm -
1 stop11h 52m
Fri 1/88:15 am -
3 stops37h 26m
Deal found 11/4![LATAM Airlines logo]()
$1,057
This LATAM Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/3010:05 am -
1 stop18h 35m
Tue 12/19:45 am -
2 stops17h 20m
Deal found 11/3![LATAM Airlines logo]()
$1,138
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/710:47 am -
2 stops17h 43m
Mon 11/911:10 pm -
1 stop20h 33m
Deal found 11/3![Delta logo]()
$1,163
This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/286:00 am -
2 stops22h 30m
Tue 1/1912:48 am -
2 stops25h 38m
Deal found 11/5![Delta logo]()
$1,166
This LATAM Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/293:48 pm -
3 stops20h 12m
Tue 1/199:45 am -
2 stops26h 32m
Deal found 11/5![LATAM Airlines logo]()
$1,170
This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/277:15 pm -
1 stop33h 25m
Mon 1/1811:00 pm -
1 stop15h 04m
Deal found 11/5![Delta logo]()
$1,175
This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/2912:37 pm -
1 stop15h 03m
Sat 1/238:25 pm -
2 stops15h 52m
Deal found 11/5![Delta logo]()
$1,177
Best flights from St. Louis to SantiagoDiscover carefully curated flight deals from St. Louis to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 7, 2026.
Discover carefully curated flight deals from St. Louis to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 7, 2026.
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/156:49 pm -
2 stops17h 06m
Tue 3/211:10 pm -
1 stop12h 59m
Deal found 11/3![Delta logo]()
$1,116
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/1510:05 am -
1 stop19h 45m
Tue 3/210:45 pm -
1 stop21h 01m
Deal found 11/2![United Airlines logo]()
$1,116
This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/13:40 pm -
2 stops21h 25m
Thu 4/86:00 pm -
2 stops17h 48m
Deal found 11/5![Delta logo]()
$1,166
This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/286:00 am -
1 stop21h 40m
Mon 1/1811:00 pm -
1 stop13h 17m
Deal found 11/5![Delta logo]()
$1,166
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/146:00 am -
1 stop22h 40m
Mon 1/1811:00 pm -
1 stop27h 26m
Deal found 11/3![Delta logo]()
$1,193
Last-minute flights from St. Louis to SantiagoDiscover last-minute flight deals from St. Louis to Santiago. Data last updated November 7, 2026 and is based on user searches.
Discover last-minute flight deals from St. Louis to Santiago. Data last updated November 7, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/72:55 pm -
1 stop14h 55m
Mon 11/910:45 pm -
1 stop22h 53m
Deal found 11/3![United Airlines logo]()
$1,163
This Mytrip deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/253:04 pm -
3 stops35h 41m
Wed 12/94:15 pm -
2 stops34h 57m
Deal found 11/4![Multiple Airlines logo]()
$742
This LATAM Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/3010:05 am -
1 stop18h 35m
Tue 12/19:45 am -
2 stops17h 20m
Deal found 11/3![LATAM Airlines logo]()
$1,138
This FlightHub deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/223:48 pm -
1 stop11h 52m
Fri 1/88:15 am -
3 stops37h 26m
Deal found 11/4![LATAM Airlines logo]()
$1,057
This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/277:15 pm -
1 stop33h 25m
Mon 1/1811:00 pm -
1 stop15h 04m
Deal found 11/5![Delta logo]()
$1,175
This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/286:00 am -
2 stops22h 30m
Tue 1/1912:48 am -
2 stops25h 38m
Deal found 11/5![Delta logo]()
$1,166
This LATAM Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/293:48 pm -
3 stops20h 12m
Tue 1/199:45 am -
2 stops26h 32m
Deal found 11/5![LATAM Airlines logo]()
$1,170
This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/293:48 pm -
1 stop11h 52m
Sun 1/249:50 pm -
1 stop14h 27m
Deal found 11/5![Delta logo]()
$1,177
One-way flights from St. Louis to SantiagoSearch for one-way flight options from St. Louis to Santiago. Find affordable one-way fares based on user searches. Data last updated November 7, 2026.
Search for one-way flight options from St. Louis to Santiago. Find affordable one-way fares based on user searches. Data last updated November 7, 2026.
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/306:21 pm -
3 stops27h 52m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/3![Multiple Airlines logo]()
$359
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/166:20 pm -
2 stops46h 51m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/3![Multiple Airlines logo]()
$422
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/251:20 pm -
2 stops32h 04m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/5![Multiple Airlines logo]()
$428
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/36:13 pm -
2 stops30h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/3![Multiple Airlines logo]()
$454
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/306:05 pm -
3 stops56h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/3![Multiple Airlines logo]()
$491
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/1512:14 pm -
3 stops35h 34m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/3![Multiple Airlines logo]()
$512
Find flight deals from St. Louis to Santiago
Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 7, 2026.
Most accurate provider | Ovago 3 stars |
|---|---|
Most trusted provider | Ovago 3 stars |
Round-trip from | $742 (Mytrip) |
One-way from | $359 (Kiwi.com) |
Popular in | January |
Cheapest in | October |
Average price | $1,405 |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 7, 2026.
Use the filters below to find and compare flights from St. Louis to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisSantiago
STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez
STLSCL
Lambert-St Louis
Wed 12/30
6:21 pm-1:13 am
3 stops27h 52m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$359
St. LouisSantiago
STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez
STLSCL
Lambert-St Louis
Wed 12/16
6:20 pm-8:11 pm
2 stops46h 51m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$422
St. LouisSantiago
STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez
STLSCL
Lambert-St Louis
Wed 11/25
1:20 pm-12:24 am
2 stops32h 04m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$428
St. LouisSantiago
STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez
STLSCL
Lambert-St Louis
Sun 11/15
4:26 pm-2:48 am
2 stops31h 22m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$555
St. LouisSantiago
STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez
STLSCL
Lambert-St Louis
Thu 12/3
12:36 pm-7:40 am
1 stop16h 04m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$574
St. LouisSantiago
STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez
STLSCL
Lambert-St Louis
Mon 11/30
12:29 pm-7:40 am
1 stop16h 11m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$574
St. LouisSantiago
STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez
STLSCL
Lambert-St Louis
Mon 11/30
5:30 pm-3:00 pm
2 stops18h 30m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$574
Quickest round-trip
St. LouisSantiago
STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez
STLSCL
Lambert-St Louis
Wed 11/25
2:31 pm-7:40 am
1 stop14h 09m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$574
St. LouisSantiago
STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez
STLSCL
Lambert-St Louis
Wed 12/16
6:00 am-6:40 am
1 stop21h 40m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$574
St. LouisSantiago
STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez
STLSCL
Lambert-St Louis
Mon 2/15
6:49 pm-2:55 pm
2 stops17h 06m
Santiago Arturo Merino Benitez
Tue 3/2
11:10 pm-9:09 am
1 stop12h 59m
$1,116
Showing 1-10 of 14 resultsSorted by cheapest first
Compare providers for flights from St. Louis to Santiago
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Santiago in November.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on St. Louis-Santiago flights, users find the pricing of Ovago to be most consistent on Cheapflights vs. Ovago Users can find the same prices on St. Louis-Santiago flight deals on Cheapflights vs. Ovago >95% of the time. Price accuracy is based on data collected from St. Louis-Santiago flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on St. Louis-Santiago flights, Cheapflights users trust Ovago the most. Ovago has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from St. Louis to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from St. Louis with our price prediction graph.
STL-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to Santiago
What is the cheapest month to book a flight from St. Louis to Santiago?
Currently, October is the cheapest month in which you can book a flight from St. Louis to Santiago (average of $995). Flying from St. Louis to Santiago in January is currently the most expensive (average of $1,667). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from St. Louis to Santiago?
Airfare is below average for this route at the moment.
St. Louis to Santiago flights typically cost between $1,258 and $1,405 in November.The cheapest round-trip price found within the last 5 days was $742 on Multiple Airlines (Nov 25-Dec 9).
Reviews of airlines servicing Santiago
Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated November 7, 2026.
Peruse reviews from past customers who have flown with Delta,LATAM Airlines, andAmerican Airlines from St. Louis to Santiago to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.8
Entertainment
7.8
Comfort
7.8
Crew
8.5
Boarding
8.1
Food
7.2
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Overall
7.8
Entertainment
7.8
Comfort
7.8
Crew
8.5
Boarding
8.1
Food
7.2
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Overall
7.8
Entertainment
7.8
Comfort
7.8
Crew
8.5
Boarding
8.1
Food
7.2
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Overall
7.8
Entertainment
7.8
Comfort
7.8
Crew
8.5
Boarding
8.1
Food
7.2
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Related info for your journey
Find useful and relevant information for your journey from St. Louis to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Alternative routes for St. Louis to Santiago
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Complete your trip
Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from St. Louis to Santiago, based on your preferred cabin class, be it economy, premium economy, business, or first class.
St. Louis and Santiago flights
Browse other St. Louis and Santiago flight options. Last updated on November 7, 2026.
Other flights from St. Louis
Browse through other flights departing from St. Louis. Flights are based on user searches made on Cheapflights and were last updated on November 7, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on November 7, 2026.
Top 3 airlines flying from St. Louis to Santiago
Discover the top 3 airlines that operate flights from St. Louis to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 7, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$792 | Average$1,064 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$858 | Average$1,227 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$894 | Average$1,255 | FlexibilityNo cancel fee | On-time71% |