$479+ Cheap flights from St. Louis (STL) to Santiago (SCL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/10. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SCL
Jul 21 — Jul 281
Round-trip
1 adult, Economy
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Find cheap flights from St. Louis to Santiago with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from St. Louis to Santiago
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Best
Last-minute
One-way
Cheapest flights from St. Louis to SantiagoExplore the most affordable flight options available from St. Louis to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 21, 2026.
Explore the most affordable flight options available from St. Louis to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 21, 2026.
This American Airlines deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/111:35 am
STL
- SCL
1 stop17h 50m
American Airlines
Sun 9/69:50 pm
SCL
- STL
1 stop14h 55m
American Airlines
Deal found 6/20![American Airlines logo]()
$947
This LATAM Airlines deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/26:00 am
STL
- SCL
3 stops27h 49m
LATAM Airlines
Mon 9/74:30 pm
SCL
- STL
2 stops33h 12m
LATAM Airlines
Deal found 6/20![LATAM Airlines logo]()
$957
This LATAM Airlines deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/112:52 pm
STL
- SCL
3 stops23h 33m
LATAM Airlines
Sun 9/69:30 pm
SCL
- STL
2 stops28h 28m
LATAM Airlines
Deal found 6/20![LATAM Airlines logo]()
$962
This Expedia deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/16:00 am
STL
- SCL
1 stop22h 40m
LATAM Airlines
Mon 12/1412:55 am
SCL
- STL
1 stop19h 11m
LATAM Airlines
Deal found 6/16![LATAM Airlines logo]()
$978
This Expedia deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/283:42 pm
STL
- SCL
2 stops22h 48m
LATAM Airlines
Wed 11/1112:10 am
SCL
- STL
1 stop13h 38m
LATAM Airlines
Deal found 6/19![LATAM Airlines logo]()
$983
This Orbitz deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/141:22 pm
STL
- SCL
3 stops23h 03m
LATAM Airlines
Tue 7/218:40 pm
SCL
- STL
1 stop14h 03m
LATAM Airlines
Deal found 6/16![LATAM Airlines logo]()
$988
This Expedia deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/181:30 pm
STL
- SCL
3 stops21h 00m
LATAM Airlines
Wed 11/258:45 am
SCL
- STL
2 stops17h 54m
LATAM Airlines
Deal found 6/17![LATAM Airlines logo]()
$993
This LATAM Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/45:36 pm
STL
- SCL
1 stop12h 39m
LATAM Airlines
Sat 7/116:00 pm
SCL
- STL
3 stops24h 53m
LATAM Airlines
Deal found 6/16![LATAM Airlines logo]()
$1,027
This United Airlines deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/81:08 pm
STL
- SCL
2 stops16h 42m
United Airlines
Wed 11/1110:45 pm
SCL
- STL
1 stop14h 20m
United Airlines
Deal found 6/20![United Airlines logo]()
$1,161
Best flights from St. Louis to SantiagoDiscover carefully curated flight deals from St. Louis to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 21, 2026.
Discover carefully curated flight deals from St. Louis to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 21, 2026.
This United Airlines deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/281:08 pm
STL
- SCL
2 stops16h 42m
United Airlines
Wed 11/1110:45 pm
SCL
- STL
1 stop22h 40m
United Airlines
Deal found 6/19![United Airlines logo]()
$947
This American Airlines deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/211:35 am
STL
- SCL
1 stop18h 30m
American Airlines
Mon 9/79:50 pm
SCL
- STL
1 stop14h 49m
American Airlines
Deal found 6/20![American Airlines logo]()
$947
This LATAM Airlines deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/26:00 am
STL
- SCL
3 stops27h 49m
LATAM Airlines
Mon 9/74:30 pm
SCL
- STL
2 stops33h 12m
LATAM Airlines
Deal found 6/20![LATAM Airlines logo]()
$957
This United Airlines deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1811:00 am
STL
- SCL
1 stop18h 50m
United Airlines
Wed 11/2510:45 pm
SCL
- STL
1 stop20h 50m
United Airlines
Deal found 6/17![United Airlines logo]()
$947
This American Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/19:32 am
STL
- SCL
2 stops19h 53m
American Airlines
Sun 9/69:50 pm
SCL
- STL
2 stops21h 11m
American Airlines
Deal found 6/16![American Airlines logo]()
$952
Last-minute flights from St. Louis to SantiagoDiscover last-minute flight deals from St. Louis to Santiago. Data last updated June 21, 2026 and is based on user searches.
Discover last-minute flight deals from St. Louis to Santiago. Data last updated June 21, 2026 and is based on user searches.
This LATAM Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/45:36 pm
STL
- SCL
1 stop12h 39m
LATAM Airlines
Sat 7/116:00 pm
SCL
- STL
3 stops24h 53m
LATAM Airlines
Deal found 6/16![LATAM Airlines logo]()
$1,027
This Delta deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/1410:51 am
STL
- SCL
1 stop19h 24m
Delta
Tue 7/218:40 pm
SCL
- STL
1 stop22h 13m
Delta
Deal found 6/16![Delta logo]()
$957
This Orbitz deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/141:22 pm
STL
- SCL
3 stops23h 03m
LATAM Airlines
Tue 7/218:40 pm
SCL
- STL
1 stop14h 03m
LATAM Airlines
Deal found 6/16![LATAM Airlines logo]()
$988
This Delta deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/199:24 am
STL
- SCL
1 stop20h 51m
Delta
Sun 7/268:40 pm
SCL
- STL
1 stop22h 13m
Delta
Deal found 6/20![Delta logo]()
$1,165
This Expedia deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/1910:51 am
STL
- SCL
2 stops34h 04m
LATAM Airlines
Sun 7/269:30 pm
SCL
- STL
2 stops27h 23m
LATAM Airlines
Deal found 6/20![LATAM Airlines logo]()
$1,166
One-way flights from St. Louis to SantiagoSearch for one-way flight options from St. Louis to Santiago. Find affordable one-way fares based on user searches. Data last updated June 21, 2026.
Search for one-way flight options from St. Louis to Santiago. Find affordable one-way fares based on user searches. Data last updated June 21, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/104:57 pm
STL
- SCL
3 stops53h 29m
Multiple Airlines
Deal found 6/16![Multiple Airlines logo]()
$479
This American Airlines deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/2412:55 pm
STL
- SCL
2 stops17h 10m
American Airlines
Deal found 6/20![American Airlines logo]()
$633
This LATAM Airlines deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/2411:00 am
STL
- SCL
3 stops25h 25m
LATAM Airlines
Deal found 6/20![LATAM Airlines logo]()
$638
This Delta deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/1010:51 am
STL
- SCL
1 stop19h 24m
Delta
Deal found 6/16![Delta logo]()
$694
This LATAM Airlines deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/2710:16 am
STL
- SCL
1 stop19h 59m
LATAM Airlines
Deal found 6/18![LATAM Airlines logo]()
$1,313
This Booking.com deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/271:20 pm
STL
- SCL
2 stops23h 55m
Multiple Airlines
Deal found 6/18![Multiple Airlines logo]()
$1,671
Find flight deals from St. Louis to Santiago
Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 21, 2026.
Most accurate provider | Ovago 3 stars |
|---|---|
Most trusted provider | Ovago 3 stars |
Round-trip from | $947 (American Airlines) |
One-way from | $479 (Kiwi.com) |
Popular in | January |
Cheapest in | March |
Average price | $1,605 |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 21, 2026.
Use the filters below to find and compare flights from St. Louis to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Wed 10/28
1:08 pm-7:50 am
2 stops16h 42m
Santiago Arturo Merino Benitez
Wed 11/11
10:45 pm-6:25 pm
1 stop22h 40m
$947
Quickest round-trip
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Wed 9/2
11:35 am-7:05 am
1 stop18h 30m
Santiago Arturo Merino Benitez
Mon 9/7
9:50 pm-10:39 am
1 stop14h 49m
$947
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Wed 11/18
11:00 am-8:50 am
1 stop18h 50m
Santiago Arturo Merino Benitez
Wed 11/25
10:45 pm-4:35 pm
1 stop20h 50m
$947
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Tue 9/1
9:32 am-6:25 am
2 stops19h 53m
Santiago Arturo Merino Benitez
Sun 9/6
9:50 pm-5:01 pm
2 stops21h 11m
$952
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Wed 9/2
6:00 am-10:49 am
3 stops27h 49m
Santiago Arturo Merino Benitez
Mon 9/7
4:30 pm-11:42 pm
2 stops33h 12m
$957
Cheapest one-way
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Fri 7/10
4:09 pm-11:26 pm
2 stops54h 17m
$577
Quickest one-way
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Mon 8/24
12:55 pm-7:05 am
2 stops17h 10m
$633
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Mon 8/24
11:00 am-1:25 pm
3 stops25h 25m
$638
Sorted by cheapest first
Compare providers for flights from St. Louis to Santiago
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Santiago in June.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on St. Louis-Santiago flights, users find the pricing of Ovago to be most consistent on Cheapflights vs. Ovago Users can find the same prices on St. Louis-Santiago flight deals on Cheapflights vs. Ovago >95% of the time. Price accuracy is based on data collected from St. Louis-Santiago flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on St. Louis-Santiago flights, Cheapflights users trust Ovago the most. Ovago has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from St. Louis to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from St. Louis with our price prediction graph.
STL-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to Santiago
What is the cheapest month to book a flight from St. Louis to Santiago?
Currently, March is the cheapest month in which you can book a flight from St. Louis to Santiago (average of $823). Flying from St. Louis to Santiago in January is currently the most expensive (average of $1,948). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from St. Louis to Santiago?
Reviews of airlines servicing Santiago
Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated June 21, 2026.
Peruse reviews from past customers who have flown with Delta,LATAM Airlines, andAmerican Airlines from St. Louis to Santiago to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.2
Entertainment
7.8
Overall
7.8
Comfort
7.8
Crew
8.5
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Food
7.2
Entertainment
7.8
Overall
7.8
Comfort
7.8
Crew
8.5
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Food
7.2
Entertainment
7.8
Overall
7.8
Comfort
7.8
Crew
8.5
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Food
7.2
Entertainment
7.8
Overall
7.8
Comfort
7.8
Crew
8.5
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from St. Louis to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Alternative routes for St. Louis to Santiago
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Complete your trip
Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from St. Louis to Santiago by cabin class
Find flights from St. Louis to Santiago, based on your preferred cabin class, be it economy, premium economy, business, or first class.
St. Louis and Santiago flights
Browse other St. Louis and Santiago flight options. Last updated on June 21, 2026.
Other flights from St. Louis
Browse through other flights departing from St. Louis. Flights are based on user searches made on Cheapflights and were last updated on June 21, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on June 21, 2026.
Top 3 airlines flying from St. Louis to Santiago
Discover the top 3 airlines that operate flights from St. Louis to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 21, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$574 | Average$894 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$611 | Average$1,112 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$792 | Average$908 | FlexibilityNo cancel fee | On-time81% |