$426+ Cheap flights from St. Louis (STL) to Santiago (SCL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/1. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SCL
Apr 23 — Apr 301
Round-trip
1 adult, Economy
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Find cheap flights from St. Louis to Santiago with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from St. Louis to Santiago
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Cheapest flights from St. Louis to SantiagoExplore the most affordable flight options available from St. Louis to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 24, 2026.
Explore the most affordable flight options available from St. Louis to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 24, 2026.
This American Airlines deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/52:33 pm
STL
- SCL
2 stops15h 32m
American Airlines
Tue 5/128:35 pm
SCL
- STL
1 stop14h 41m
American Airlines
Deal found 3/20![American Airlines logo]()
$820
This Delta deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/56:50 pm
STL
- SCL
2 stops18h 15m
Delta
Tue 5/127:55 pm
SCL
- STL
2 stops17h 25m
Delta
Deal found 3/20![Delta logo]()
$875
This LATAM Airlines deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/511:42 am
STL
- SCL
3 stops22h 07m
LATAM Airlines
Tue 5/127:50 am
SCL
- STL
2 stops17h 09m
LATAM Airlines
Deal found 3/20![LATAM Airlines logo]()
$880
This American Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/711:06 am
STL
- SCL
1 stop18h 59m
American Airlines
Thu 5/148:35 pm
SCL
- STL
1 stop14h 41m
American Airlines
Deal found 3/23![American Airlines logo]()
$892
This LATAM Airlines deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/2411:51 am
STL
- SCL
2 stops16h 34m
LATAM Airlines
Tue 9/111:00 pm
SCL
- STL
2 stops20h 02m
LATAM Airlines
Deal found 3/21![LATAM Airlines logo]()
$910
This KAYAK deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1811:51 am
STL
- SCL
2 stops16h 34m
LATAM Airlines
Wed 8/267:50 am
SCL
- STL
2 stops16h 47m
LATAM Airlines
Deal found 3/23![LATAM Airlines logo]()
$925
This KAYAK deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/167:05 pm
STL
- SCL
2 stops23h 40m
LATAM Airlines
Thu 8/278:40 pm
SCL
- STL
1 stop22h 22m
LATAM Airlines
Deal found 3/23![LATAM Airlines logo]()
$930
This KAYAK deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/1411:51 am
STL
- SCL
1 stop18h 24m
LATAM Airlines
Thu 8/278:40 pm
SCL
- STL
1 stop22h 22m
LATAM Airlines
Deal found 3/23![LATAM Airlines logo]()
$975
This Delta deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/165:00 pm
STL
- SCL
1 stop36h 50m
Delta
Sun 8/3010:55 pm
SCL
- STL
1 stop17h 48m
Delta
Deal found 3/23![Delta logo]()
$985
This Kiwi.com deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/166:30 am
STL
- SCL
1 stop13h 40m
Multiple Airlines
Thu 8/273:35 am
SCL
- STL
2 stops21h 39m
Multiple Airlines
Deal found 3/23![Multiple Airlines logo]()
$996
This Expedia deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/77:01 pm
STL
- SCL
3 stops25h 14m
LATAM Airlines
Thu 5/148:30 am
SCL
- STL
3 stops26h 14m
LATAM Airlines
Deal found 3/23![LATAM Airlines logo]()
$1,003
Best flights from St. Louis to SantiagoDiscover carefully curated flight deals from St. Louis to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 24, 2026.
Discover carefully curated flight deals from St. Louis to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 24, 2026.
This Delta deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/511:42 am
STL
- SCL
1 stop18h 33m
Delta
Tue 5/1210:55 pm
SCL
- STL
1 stop19h 10m
Delta
Deal found 3/20![Delta logo]()
$875
This LATAM Airlines deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/2411:51 am
STL
- SCL
2 stops16h 34m
LATAM Airlines
Tue 9/111:00 pm
SCL
- STL
2 stops20h 02m
LATAM Airlines
Deal found 3/21![LATAM Airlines logo]()
$910
This United Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/176:14 am
STL
- SCL
2 stops19h 06m
United Airlines
Sat 8/294:14 am
SCL
- STL
2 stops30h 55m
United Airlines
Deal found 3/23![United Airlines logo]()
$1,148
This American Airlines deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/31:09 pm
STL
- SCL
2 stops16h 41m
American Airlines
Sat 7/118:30 pm
SCL
- STL
2 stops16h 25m
American Airlines
Deal found 3/20![American Airlines logo]()
$1,155
This Expedia deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/157:05 pm
STL
- SCL
2 stops47h 40m
LATAM Airlines
Sat 8/298:40 pm
SCL
- STL
1 stop22h 22m
LATAM Airlines
Deal found 3/21![LATAM Airlines logo]()
$1,023
This Delta deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/810:49 am
STL
- SCL
1 stop19h 26m
Delta
Fri 5/1510:30 am
SCL
- STL
2 stops24h 19m
Delta
Deal found 3/24![Delta logo]()
$1,033
This LATAM Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/810:49 am
STL
- SCL
2 stops17h 36m
LATAM Airlines
Fri 5/156:10 pm
SCL
- STL
2 stops19h 46m
LATAM Airlines
Deal found 3/24![LATAM Airlines logo]()
$1,030
This Delta deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/31:39 pm
STL
- SCL
1 stop16h 36m
Delta
Sat 7/1110:55 pm
SCL
- STL
1 stop19h 03m
Delta
Deal found 3/21![Delta logo]()
$1,075
Last-minute flights from St. Louis to SantiagoDiscover last-minute flight deals from St. Louis to Santiago. Data last updated March 24, 2026 and is based on user searches.
Discover last-minute flight deals from St. Louis to Santiago. Data last updated March 24, 2026 and is based on user searches.
This Ovago deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/2610:50 am
STL
- SCL
2 stops16h 45m
LATAM Airlines
Sat 3/288:50 am
SCL
- STL
2 stops17h 08m
LATAM Airlines
Deal found 3/22![LATAM Airlines logo]()
$1,555
This KAYAK deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/316:30 am
STL
- SCL
2 stops21h 33m
Copa Airlines
Thu 4/2311:25 am
SCL
- STL
2 stops22h 00m
Copa Airlines
Deal found 3/21![Copa Airlines logo]()
$1,116
This KAYAK deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/3112:04 pm
STL
- SCL
2 stops16h 51m
LATAM Airlines
Thu 4/238:40 pm
SCL
- STL
1 stop14h 54m
LATAM Airlines
Deal found 3/21![LATAM Airlines logo]()
$1,184
This KAYAK deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/209:10 am
STL
- SCL
2 stops19h 00m
Copa Airlines
Fri 4/2411:25 am
SCL
- STL
2 stops24h 20m
Copa Airlines
Deal found 3/23![Copa Airlines logo]()
$1,123
This LATAM Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/209:59 am
STL
- SCL
2 stops19h 01m
LATAM Airlines
Wed 4/225:40 am
SCL
- STL
2 stops18h 56m
LATAM Airlines
Deal found 3/23![LATAM Airlines logo]()
$1,245
This Mytrip deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/209:10 am
STL
- SCL
3 stops28h 05m
Multiple Airlines
Fri 4/246:00 am
SCL
- STL
2 stops34h 25m
Multiple Airlines
Deal found 3/23![Multiple Airlines logo]()
$1,263
This KAYAK deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/209:59 am
STL
- SCL
2 stops19h 01m
LATAM Airlines
Fri 4/248:40 pm
SCL
- STL
1 stop14h 54m
LATAM Airlines
Deal found 3/23![LATAM Airlines logo]()
$1,275
One-way flights from St. Louis to SantiagoSearch for one-way flight options from St. Louis to Santiago. Find affordable one-way fares based on user searches. Data last updated March 24, 2026.
Search for one-way flight options from St. Louis to Santiago. Find affordable one-way fares based on user searches. Data last updated March 24, 2026.
This Kiwi.com deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/18:16 pm
STL
- SCL
3 stops31h 29m
Multiple Airlines
Deal found 3/23![Multiple Airlines logo]()
$426
This Delta deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/110:12 am
STL
- SCL
1 stop20h 03m
Delta
Deal found 3/23![Delta logo]()
$534
This eDestinos deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/304:10 pm
STL
- SCL
3 stops47h 25m
Multiple Airlines
Deal found 3/22![Multiple Airlines logo]()
$561
This American Airlines deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/3011:00 am
STL
- SCL
1 stop18h 50m
American Airlines
Deal found 3/22![American Airlines logo]()
$596
Find flight deals from St. Louis to Santiago
Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 24, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $820 (American Airlines) |
One-way from | $426 (Kiwi.com) |
Popular in | January |
Cheapest in | March |
Average price | $833 |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 24, 2026.
Use the filters below to find and compare flights from St. Louis to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Tue 5/5
11:42 am-7:15 am
1 stop18h 33m
Santiago Arturo Merino Benitez
Tue 5/12
10:55 pm-5:05 pm
1 stop19h 10m
$875
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Mon 8/24
11:51 am-5:25 am
2 stops16h 34m
Santiago Arturo Merino Benitez
Tue 9/1
11:00 pm-6:02 pm
2 stops20h 02m
$910
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Sat 8/15
7:05 pm-7:45 pm
2 stops47h 40m
Santiago Arturo Merino Benitez
Sat 8/29
8:40 pm-6:02 pm
1 stop22h 22m
$1,023
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Fri 5/8
10:49 am-5:25 am
2 stops17h 36m
Santiago Arturo Merino Benitez
Fri 5/15
6:10 pm-12:56 pm
2 stops19h 46m
$1,030
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Fri 5/8
10:49 am-7:15 am
1 stop19h 26m
Santiago Arturo Merino Benitez
Fri 5/15
10:30 am-9:49 am
2 stops24h 19m
$1,033
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Fri 7/3
1:39 pm-7:15 am
1 stop16h 36m
Santiago Arturo Merino Benitez
Sat 7/11
10:55 pm-4:58 pm
1 stop19h 03m
$1,075
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Mon 8/17
6:14 am-2:20 am
2 stops19h 06m
Santiago Arturo Merino Benitez
Sat 8/29
4:14 am-10:09 am
2 stops30h 55m
$1,148
Quickest round-trip
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Fri 7/3
1:09 pm-6:50 am
2 stops16h 41m
Santiago Arturo Merino Benitez
Sat 7/11
8:30 pm-11:55 am
2 stops16h 25m
$1,155
Cheapest one-way
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Wed 4/1
8:16 pm-5:45 am
3 stops31h 29m
$426
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Wed 4/1
10:12 am-8:15 am
1 stop20h 03m
$534
Showing 1-10 of 12 resultsSorted by cheapest first
Compare providers for flights from St. Louis to Santiago
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Santiago in March.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*2 stars |
- Most accurate provider: When it comes to deals on St. Louis-Santiago flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on St. Louis-Santiago flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from St. Louis-Santiago flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on St. Louis-Santiago flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from St. Louis to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from St. Louis with our price prediction graph.
STL-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to Santiago
What is the cheapest month to book a flight from St. Louis to Santiago?
Currently, March is the cheapest month in which you can book a flight from St. Louis to Santiago (average of $549). Flying from St. Louis to Santiago in June is currently the most expensive (average of $989). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from St. Louis to Santiago?
Reviews of airlines servicing Santiago
Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated March 24, 2026.
Peruse reviews from past customers who have flown with Delta,LATAM Airlines, andAmerican Airlines from St. Louis to Santiago to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Crew
8.5
Food
7.2
Entertainment
7.8
Overall
7.9
Comfort
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Boarding
8.1
Crew
8.5
Food
7.2
Entertainment
7.8
Overall
7.9
Comfort
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Boarding
8.1
Crew
8.5
Food
7.2
Entertainment
7.8
Overall
7.9
Comfort
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Boarding
8.1
Crew
8.5
Food
7.2
Entertainment
7.8
Overall
7.9
Comfort
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Related info for your journey
Find useful and relevant information for your journey from St. Louis to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Complete your trip
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Other flights from St. Louis
Popular flights
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Alternative routes for St. Louis to Santiago
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Complete your trip
Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from St. Louis to Santiago by cabin class
Find flights from St. Louis to Santiago, based on your preferred cabin class, be it economy, premium economy, business, or first class.
St. Louis and Santiago flights
Browse other St. Louis and Santiago flight options. Last updated on March 24, 2026.
Other flights from St. Louis
Browse through other flights departing from St. Louis. Flights are based on user searches made on Cheapflights and were last updated on March 24, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on March 24, 2026.
Top 3 airlines flying from St. Louis to Santiago
Discover the top 3 airlines that operate flights from St. Louis to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 24, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$611 | Average$1,003 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$689 | Average$898 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$803 | Average$898 | FlexibilityNo cancel fee | On-time81% |