$501+ Cheap flights from St. Louis (STL) to Santiago (SCL)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/28. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SCL
Nov 24 — Dec 11
Round-trip
1 adult, Economy
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Find cheap flights from St. Louis to Santiago with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from St. Louis to Santiago
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Best
Last-minute
One-way
Cheapest flights from St. Louis to SantiagoExplore the most affordable flight options available from St. Louis to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 25, 2026.
Explore the most affordable flight options available from St. Louis to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 25, 2026.
This LATAM Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/156:00 am -
1 stop22h 40m
Tue 12/2912:48 am -
2 stops26h 07m
Deal found 10/21![LATAM Airlines logo]()
$958
This LATAM Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1012:36 pm -
1 stop16h 04m
Tue 12/2912:48 am -
2 stops26h 07m
Deal found 10/21![LATAM Airlines logo]()
$1,037
This LATAM Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/112:33 pm -
1 stop14h 07m
Tue 12/2912:48 am -
2 stops26h 07m
Deal found 10/21![LATAM Airlines logo]()
$1,048
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/286:00 am -
1 stop21h 40m
Fri 1/159:50 pm -
1 stop15h 58m
Deal found 10/21![Delta logo]()
$1,127
This LATAM Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/283:48 pm -
3 stops20h 12m
Fri 1/159:50 pm -
1 stop15h 58m
Deal found 10/21![LATAM Airlines logo]()
$1,131
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/52:33 pm -
2 stops21h 27m
Sat 12/128:25 pm -
2 stops20h 03m
Deal found 10/21![Delta logo]()
$1,138
This LATAM Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/52:33 pm -
3 stops21h 27m
Sat 12/1211:10 pm -
2 stops20h 14m
Deal found 10/21![LATAM Airlines logo]()
$1,142
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/106:00 am -
2 stops22h 30m
Tue 12/2912:48 am -
2 stops18h 40m
Deal found 10/21![Delta logo]()
$1,152
This United Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/88:02 am -
2 stops21h 48m
Tue 12/1510:45 pm -
2 stops18h 56m
Deal found 10/24![United Airlines logo]()
$1,156
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/135:31 pm -
1 stop34h 09m
Tue 12/2912:48 am -
2 stops26h 07m
Deal found 10/21![Delta logo]()
$1,160
Best flights from St. Louis to SantiagoDiscover carefully curated flight deals from St. Louis to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 25, 2026.
Discover carefully curated flight deals from St. Louis to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 25, 2026.
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/156:15 am -
1 stop23h 35m
Tue 3/210:45 pm -
1 stop20h 59m
Deal found 10/20![United Airlines logo]()
$1,116
This Delta deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/119:00 am -
2 stops19h 30m
Wed 1/209:50 pm -
1 stop23h 11m
Deal found 10/23![Delta logo]()
$1,116
This United Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/116:15 am -
1 stop23h 35m
Wed 1/2010:45 pm -
1 stop13h 46m
Deal found 10/23![United Airlines logo]()
$1,116
This Delta deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/207:20 am -
2 stops20h 35m
Sat 3/68:13 am -
2 stops18h 26m
Deal found 10/24![Delta logo]()
$1,142
This United Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/206:15 am -
2 stops23h 35m
Sat 3/610:45 pm -
2 stops49h 28m
Deal found 10/25![United Airlines logo]()
$1,161
Last-minute flights from St. Louis to SantiagoDiscover last-minute flight deals from St. Louis to Santiago. Data last updated October 25, 2026 and is based on user searches.
Discover last-minute flight deals from St. Louis to Santiago. Data last updated October 25, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/242:25 pm -
2 stops18h 50m
Thu 10/296:30 pm -
2 stops18h 21m
Deal found 10/21![Delta logo]()
$1,163
This Mytrip deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/248:55 am -
2 stops35h 15m
Thu 10/296:58 am -
3 stops34h 25m
Deal found 10/21![Multiple Airlines logo]()
$1,459
This Flightnetwork deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flightnetwork is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/298:00 am -
2 stops19h 45m
Fri 10/304:15 pm -
2 stops19h 57m
Deal found 10/22![Avianca logo]()
$1,543
This Delta deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/187:13 am -
1 stop21h 27m
Wed 11/253:50 pm -
2 stops21h 11m
Deal found 10/20![Delta logo]()
$1,188
This LATAM Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/182:31 pm -
3 stops21h 29m
Wed 11/258:25 pm -
2 stops16h 36m
Deal found 10/20![LATAM Airlines logo]()
$1,609
This Delta deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/216:00 am -
1 stop22h 40m
Sat 11/288:13 am -
2 stops18h 43m
Deal found 10/24![Delta logo]()
$1,287
This American Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/219:03 am -
2 stops21h 22m
Sat 11/2810:30 pm -
1 stop13h 41m
Deal found 10/24![American Airlines logo]()
$1,380
This Mytrip deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/216:05 pm -
3 stops31h 55m
Fri 11/272:10 am -
2 stops24h 49m
Deal found 10/24![Multiple Airlines logo]()
$1,398
This LATAM Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/2112:29 pm -
3 stops23h 31m
Sat 11/285:55 pm -
2 stops18h 05m
Deal found 10/24![LATAM Airlines logo]()
$1,566
One-way flights from St. Louis to SantiagoSearch for one-way flight options from St. Louis to Santiago. Find affordable one-way fares based on user searches. Data last updated October 25, 2026.
Search for one-way flight options from St. Louis to Santiago. Find affordable one-way fares based on user searches. Data last updated October 25, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/285:58 pm -
3 stops32h 07m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/23![Multiple Airlines logo]()
$501
This Kiwi.com deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/185:59 pm -
3 stops47h 59m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/23![Multiple Airlines logo]()
$583
This Expedia deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/286:00 am -
1 stop22h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/23![LATAM Airlines logo]()
$660
This Expedia deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/93:40 pm -
2 stops20h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/20![LATAM Airlines logo]()
$665
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/96:00 am -
3 stops25h 53m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/20![Multiple Airlines logo]()
$670
This United Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/186:10 am -
1 stop23h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/23![United Airlines logo]()
$723
This FlightHub deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/1811:51 am -
2 stops31h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/23![LATAM Airlines logo]()
$736
Find flight deals from St. Louis to Santiago
Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 25, 2026.
Most accurate provider | Ovago 3 stars |
|---|---|
Most trusted provider | Ovago 3 stars |
Round-trip from | $958 (LATAM Airlines) |
One-way from | $501 (Kiwi.com) |
Popular in | January |
Cheapest in | March |
Average price | $995 |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 25, 2026.
Use the filters below to find and compare flights from St. Louis to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisSantiago
STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez
STLSCL
Lambert-St Louis
Mon 12/28
5:58 pm-5:05 am
3 stops32h 07m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$501
St. LouisSantiago
STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez
STLSCL
Lambert-St Louis
Thu 2/18
4:05 pm-1:16 pm
2 stops18h 11m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$614
Quickest round-trip
St. LouisSantiago
STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez
STLSCL
Lambert-St Louis
Tue 2/9
3:40 pm-7:40 am
1 stop13h 00m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$660
St. LouisSantiago
STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez
STLSCL
Lambert-St Louis
Tue 2/9
6:00 am-10:53 am
3 stops25h 53m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$670
St. LouisSantiago
STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez
STLSCL
Lambert-St Louis
Thu 2/18
6:10 am-8:50 am
1 stop23h 40m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$723
St. LouisSantiago
STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez
STLSCL
Lambert-St Louis
Thu 2/18
11:51 am-9:51 pm
2 stops31h 00m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$736
St. LouisSantiago
STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez
STLSCL
Lambert-St Louis
Mon 2/15
6:15 am-8:50 am
1 stop23h 35m
Santiago Arturo Merino Benitez
Tue 3/2
10:45 pm-4:44 pm
1 stop20h 59m
$1,116
St. LouisSantiago
STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez
STLSCL
Lambert-St Louis
Mon 1/11
9:00 am-7:30 am
2 stops19h 30m
Santiago Arturo Merino Benitez
Wed 1/20
9:50 pm-6:01 pm
1 stop23h 11m
$1,116
St. LouisSantiago
STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez
STLSCL
Lambert-St Louis
Mon 1/11
6:15 am-8:50 am
1 stop23h 35m
Santiago Arturo Merino Benitez
Wed 1/20
10:45 pm-9:31 am
1 stop13h 46m
$1,116
St. LouisSantiago
STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez
STLSCL
Lambert-St Louis
Sat 2/20
7:20 am-6:55 am
2 stops20h 35m
Santiago Arturo Merino Benitez
Sat 3/6
8:13 am-11:39 pm
2 stops18h 26m
$1,142
Showing 1-10 of 11 resultsSorted by cheapest first
Compare providers for flights from St. Louis to Santiago
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Santiago in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on St. Louis-Santiago flights, users find the pricing of Ovago to be most consistent on Cheapflights vs. Ovago Users can find the same prices on St. Louis-Santiago flight deals on Cheapflights vs. Ovago >95% of the time. Price accuracy is based on data collected from St. Louis-Santiago flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on St. Louis-Santiago flights, Cheapflights users trust Ovago the most. Ovago has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from St. Louis to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from St. Louis with our price prediction graph.
STL-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to Santiago
What is the cheapest month to book a flight from St. Louis to Santiago?
Currently, March is the cheapest month in which you can book a flight from St. Louis to Santiago (average of $898). Flying from St. Louis to Santiago in January is currently the most expensive (average of $1,667). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from St. Louis to Santiago?
Airfare is below average for this route at the moment.
St. Louis to Santiago flights typically cost between $1,126 and $1,200 in December.The cheapest round-trip price found within the last 5 days was $958 on LATAM Airlines (Dec 15-Dec 29).
Reviews of airlines servicing Santiago
Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated October 25, 2026.
Peruse reviews from past customers who have flown with Delta,LATAM Airlines, andAmerican Airlines from St. Louis to Santiago to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Overall
7.8
Crew
8.5
Comfort
7.8
Entertainment
7.8
Food
7.2
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Boarding
8.1
Overall
7.8
Crew
8.5
Comfort
7.8
Entertainment
7.8
Food
7.2
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Boarding
8.1
Overall
7.8
Crew
8.5
Comfort
7.8
Entertainment
7.8
Food
7.2
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Boarding
8.1
Overall
7.8
Crew
8.5
Comfort
7.8
Entertainment
7.8
Food
7.2
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Related info for your journey
Find useful and relevant information for your journey from St. Louis to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Alternative routes for St. Louis to Santiago
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Complete your trip
Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from St. Louis to Santiago, based on your preferred cabin class, be it economy, premium economy, business, or first class.
St. Louis and Santiago flights
Browse other St. Louis and Santiago flight options. Last updated on October 25, 2026.
Other flights from St. Louis
Browse through other flights departing from St. Louis. Flights are based on user searches made on Cheapflights and were last updated on October 25, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 25, 2026.
Top 3 airlines flying from St. Louis to Santiago
Discover the top 3 airlines that operate flights from St. Louis to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 25, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$762 | Average$1,218 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$792 | Average$1,037 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$858 | Average$1,227 | FlexibilityNo cancel fee | On-timeN/A |