$421+ Cheap flights from St. Louis (STL) to Santiago (SCL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/17. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SCL
Oct 1 — Oct 81
Round-trip
1 adult, Economy
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Find cheap flights from St. Louis to Santiago with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from St. Louis to Santiago
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Best
Last-minute
One-way
Cheapest flights from St. Louis to SantiagoExplore the most affordable flight options available from St. Louis to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 1, 2026.
Explore the most affordable flight options available from St. Louis to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 1, 2026.
This Delta deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/1912:00 pm -
1 stop18h 15m
Sun 11/19:55 pm -
2 stops28h 59m
Deal found 8/30![Delta logo]()
$983
This Expedia deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/186:00 am -
2 stops22h 15m
Wed 11/2511:10 pm -
1 stop14h 10m
Deal found 8/29![LATAM Airlines logo]()
$991
This Delta deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2012:00 pm -
1 stop18h 15m
Tue 10/2711:10 pm -
1 stop13h 41m
Deal found 8/27![Delta logo]()
$995
This American Airlines deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/185:00 pm -
1 stop12h 45m
Wed 11/2510:30 pm -
1 stop14h 07m
Deal found 8/29![American Airlines logo]()
$1,021
This American Airlines deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/1212:49 pm -
2 stops17h 21m
Mon 10/199:30 pm -
2 stops17h 05m
Deal found 8/28![American Airlines logo]()
$1,026
This Delta deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/266:00 am -
2 stops21h 40m
Sat 10/38:55 pm -
2 stops20h 59m
Deal found 8/27![Delta logo]()
$1,037
This LATAM Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/15:23 pm -
2 stops23h 02m
Sun 9/66:40 am -
2 stops18h 51m
Deal found 8/27![LATAM Airlines logo]()
$1,042
This United Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:50 pm -
2 stops35h 00m
Mon 11/210:45 pm -
2 stops21h 14m
Deal found 8/31![United Airlines logo]()
$1,047
This LATAM Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/212:52 pm -
3 stops23h 33m
Mon 9/710:30 pm -
2 stops27h 12m
Deal found 8/27![LATAM Airlines logo]()
$1,052
This Orbitz deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/106:00 am -
3 stops29h 20m
Thu 12/317:00 pm -
2 stops18h 46m
Deal found 8/29![LATAM Airlines logo]()
$1,065
Best flights from St. Louis to SantiagoDiscover carefully curated flight deals from St. Louis to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 1, 2026.
Discover carefully curated flight deals from St. Louis to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 1, 2026.
This Delta deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/197:20 pm -
2 stops17h 40m
Sun 11/19:55 pm -
2 stops28h 59m
Deal found 8/30![Delta logo]()
$983
This LATAM Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/202:25 pm -
1 stop15h 50m
Tue 10/278:25 pm -
2 stops16h 26m
Deal found 8/27![LATAM Airlines logo]()
$995
This Delta deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/136:00 am -
2 stops20h 20m
Tue 1/2612:48 am -
2 stops20h 13m
Deal found 8/31![Delta logo]()
$995
This LATAM Airlines deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/261:40 pm -
1 stop16h 35m
Sat 10/38:55 pm -
2 stops16h 00m
Deal found 8/28![LATAM Airlines logo]()
$1,037
This Delta deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/183:40 pm -
2 stops20h 20m
Thu 2/2511:10 pm -
1 stop21h 51m
Deal found 8/27![Delta logo]()
$995
This Delta deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2012:00 pm -
1 stop18h 15m
Tue 10/2711:10 pm -
1 stop13h 41m
Deal found 8/27![Delta logo]()
$995
This Delta deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/266:00 am -
2 stops21h 40m
Sat 10/38:55 pm -
2 stops20h 59m
Deal found 8/27![Delta logo]()
$1,037
Last-minute flights from St. Louis to SantiagoDiscover last-minute flight deals from St. Louis to Santiago. Data last updated September 1, 2026 and is based on user searches.
Discover last-minute flight deals from St. Louis to Santiago. Data last updated September 1, 2026 and is based on user searches.
This LATAM Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/15:23 pm -
2 stops23h 02m
Sun 9/66:40 am -
2 stops18h 51m
Deal found 8/27![LATAM Airlines logo]()
$1,042
This LATAM Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/211:00 am -
2 stops29h 25m
Mon 9/710:30 pm -
2 stops27h 12m
Deal found 8/27![LATAM Airlines logo]()
$1,047
This Delta deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/25:23 pm -
1 stop12h 52m
Mon 9/78:40 pm -
1 stop29h 02m
Deal found 8/31![Delta logo]()
$1,128
This Delta deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/266:00 am -
2 stops21h 40m
Sat 10/38:55 pm -
2 stops20h 59m
Deal found 8/27![Delta logo]()
$1,037
This Expedia deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/265:46 pm -
2 stops34h 59m
Sat 10/38:40 am -
3 stops28h 15m
Deal found 8/27![LATAM Airlines logo]()
$1,073
This American Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/265:10 pm -
1 stop12h 50m
Sat 10/39:30 pm -
1 stop17h 51m
Deal found 8/30![American Airlines logo]()
$1,210
One-way flights from St. Louis to SantiagoSearch for one-way flight options from St. Louis to Santiago. Find affordable one-way fares based on user searches. Data last updated September 1, 2026.
Search for one-way flight options from St. Louis to Santiago. Find affordable one-way fares based on user searches. Data last updated September 1, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1710:20 am -
3 stops28h 05m
Deal found 8/28![Multiple Airlines logo]()
$421
This Kiwi.com deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/185:19 pm -
3 stops34h 51m
Deal found 8/28![Multiple Airlines logo]()
$556
This SmartFares deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1710:05 am -
1 stop20h 10m
Deal found 8/28![LATAM Airlines logo]()
$671
This SmartFares deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/184:59 pm -
1 stop13h 16m
Deal found 8/28![LATAM Airlines logo]()
$717
Find flight deals from St. Louis to Santiago
Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 1, 2026.
Most accurate provider | Ovago 3 stars |
|---|---|
Most trusted provider | Ovago 3 stars |
Round-trip from | $983 (Delta) |
One-way from | $421 (Kiwi.com) |
Popular in | January |
Cheapest in | March |
Average price | $1,195 |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 1, 2026.
Use the filters below to find and compare flights from St. Louis to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisSantiago
STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez
STLSCL
Lambert-St Louis
Mon 10/19
7:20 pm-3:00 pm
2 stops17h 40m
Santiago Arturo Merino Benitez
Sun 11/1
9:55 pm-11:54 pm
2 stops28h 59m
$983
St. LouisSantiago
STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez
STLSCL
Lambert-St Louis
Tue 10/20
2:25 pm-8:15 am
1 stop15h 50m
Santiago Arturo Merino Benitez
Tue 10/27
8:25 pm-10:51 am
2 stops16h 26m
$995
St. LouisSantiago
STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez
STLSCL
Lambert-St Louis
Wed 1/13
6:00 am-5:20 am
2 stops20h 20m
Santiago Arturo Merino Benitez
Tue 1/26
12:48 am-6:01 pm
2 stops20h 13m
$995
St. LouisSantiago
STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez
STLSCL
Lambert-St Louis
Thu 2/18
3:40 pm-3:00 pm
2 stops20h 20m
Santiago Arturo Merino Benitez
Thu 2/25
11:10 pm-6:01 pm
1 stop21h 51m
$995
Quickest round-trip
St. LouisSantiago
STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez
STLSCL
Lambert-St Louis
Tue 10/20
12:00 pm-8:15 am
1 stop18h 15m
Santiago Arturo Merino Benitez
Tue 10/27
11:10 pm-10:51 am
1 stop13h 41m
$995
St. LouisSantiago
STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez
STLSCL
Lambert-St Louis
Sat 9/26
1:40 pm-8:15 am
1 stop16h 35m
Santiago Arturo Merino Benitez
Sat 10/3
8:55 pm-10:55 am
2 stops16h 00m
$1,037
St. LouisSantiago
STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez
STLSCL
Lambert-St Louis
Sat 9/26
6:00 am-5:40 am
2 stops21h 40m
Santiago Arturo Merino Benitez
Sat 10/3
8:55 pm-3:54 pm
2 stops20h 59m
$1,037
Cheapest one-way
St. LouisSantiago
STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez
STLSCL
Lambert-St Louis
Thu 9/17
10:20 am-4:25 pm
3 stops28h 05m
$421
St. LouisSantiago
STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez
STLSCL
Lambert-St Louis
Fri 9/18
5:19 pm-6:10 am
3 stops34h 51m
$556
Quickest one-way
St. LouisSantiago
STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez
STLSCL
Lambert-St Louis
Thu 9/17
10:05 am-8:15 am
1 stop20h 10m
$671
Sorted by cheapest first
Compare providers for flights from St. Louis to Santiago
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Santiago in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on St. Louis-Santiago flights, users find the pricing of Ovago to be most consistent on Cheapflights vs. Ovago Users can find the same prices on St. Louis-Santiago flight deals on Cheapflights vs. Ovago >95% of the time. Price accuracy is based on data collected from St. Louis-Santiago flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on St. Louis-Santiago flights, Cheapflights users trust Ovago the most. Ovago has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from St. Louis to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from St. Louis with our price prediction graph.
STL-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to Santiago
Reviews of airlines servicing Santiago
Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated September 1, 2026.
Peruse reviews from past customers who have flown with Delta,LATAM Airlines, andAmerican Airlines from St. Louis to Santiago to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.2
Overall
7.8
Boarding
8.1
Crew
8.5
Comfort
7.8
Entertainment
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Food
7.2
Overall
7.8
Boarding
8.1
Crew
8.5
Comfort
7.8
Entertainment
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Food
7.2
Overall
7.8
Boarding
8.1
Crew
8.5
Comfort
7.8
Entertainment
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Food
7.2
Overall
7.8
Boarding
8.1
Crew
8.5
Comfort
7.8
Entertainment
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Related info for your journey
Find useful and relevant information for your journey from St. Louis to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Alternative routes for St. Louis to Santiago
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Complete your trip
Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from St. Louis to Santiago by cabin class
Find flights from St. Louis to Santiago, based on your preferred cabin class, be it economy, premium economy, business, or first class.
St. Louis and Santiago flights
Browse other St. Louis and Santiago flight options. Last updated on September 1, 2026.
Other flights from St. Louis
Browse through other flights departing from St. Louis. Flights are based on user searches made on Cheapflights and were last updated on September 1, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 1, 2026.
Top 3 airlines flying from St. Louis to Santiago
Discover the top 3 airlines that operate flights from St. Louis to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 1, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$611 | Average$1,187 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$689 | Average$898 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$792 | Average$995 | FlexibilityNo cancel fee | On-time81% |