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$281+ Cheap flights from St. Louis (STL) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/16. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SCL
ene. 3 — ene. 101
sáb. 1/3
sáb. 1/10
1 adult, Economy
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Cheapflights Tip: The best prices from Lambert-St Louis to Santiago Arturo Merino Benitez are usually found in March or July, booked 62 days in advance, depart on a Wednesday or Monday and return on a Tuesday

Cheap flight deals from St. Louis to Santiago

Cheapest flights from St. Louis to Santiago
Explore the most affordable flight options available from St. Louis to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on diciembre 4, 2025.

This LATAM Airlines deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/291:22 pmSTL - SCL
1 stop15h 18mLATAM Airlines
lun. 1/199:30 pmSCL - STL
1 stop14h 23mLATAM Airlines
Deal found 12/3$764
This United Airlines deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/116:15 amSTL - SCL
1 stop23h 35mUnited Airlines
sáb. 12/2010:45 pmSCL - STL
1 stop14h 04mUnited Airlines
Deal found 12/2$954
This Expedia deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/299:47 amSTL - SCL
1 stop18h 53mLATAM Airlines
lun. 1/1210:15 pmSCL - STL
2 stops28h 24mLATAM Airlines
Deal found 12/3$1,059
This KAYAK deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/246:00 amSTL - SCL
2 stops20h 35mLATAM Airlines
mar. 1/610:15 pmSCL - STL
2 stops28h 24mLATAM Airlines
Deal found 12/3$1,081
This American Airlines deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/296:00 pmSTL - SCL
1 stop12h 25mAmerican Airlines
lun. 1/1211:55 pmSCL - STL
1 stop20h 27mAmerican Airlines
Deal found 12/3$1,094
This United Airlines deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 12/611:10 amSTL - SCL
1 stop18h 40mUnited Airlines
mié. 12/1010:45 pmSCL - STL
1 stop14h 19mUnited Airlines
Deal found 12/1$1,124

Find flight deals from St. Louis to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated diciembre 4, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$757
(United Airlines)

One-way from

$281
(Kiwi.com)

Popular in

February

Cheapest in

March

Average price

$1,078
Provider with most accurate pricing for Lambert-St Louis-Santiago Arturo Merino Benitez flight deals.
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Provider most trusted by Cheapflights users for Lambert-St Louis-Santiago Arturo Merino Benitez flights.
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From Lambert-St Louis to Santiago Arturo Merino Benitez
Search Deals
One-way flight from Lambert-St Louis to Santiago Arturo Merino Benitez
Search Deals
Highest demand for flights based on searches. 3% potential increase in price ($30 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($13 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from St. Louis to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated diciembre 4, 2025.
Use the filters below to find and compare flights from St. Louis to Santiago that are best for you.

Fly from

St. Louis

Fly to

Santiago

Route

Depart

Return

Price

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

mié. 3/11

7:10 am-7:40 am

1 stop22h 30m

Santiago Arturo Merino Benitez

jue. 3/26

10:10 pm-8:52 am

1 stop12h 42m

$755

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

lun. 3/9

11:25 am-7:50 am

2 stops18h 25m

Santiago Arturo Merino Benitez

lun. 3/23

9:45 pm-9:21 am

1 stop13h 36m

$755

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

mar. 3/10

11:25 am-7:50 am

2 stops18h 25m

Santiago Arturo Merino Benitez

mié. 3/25

9:45 pm-2:42 pm

2 stops18h 57m

$755

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

dom. 3/8

6:59 pm-7:40 am

1 stop34h 41m

Santiago Arturo Merino Benitez

jue. 3/26

10:10 pm-8:52 am

1 stop12h 42m

$755

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

dom. 3/8

6:59 pm-7:40 am

1 stop34h 41m

Santiago Arturo Merino Benitez

mar. 3/24

10:10 pm-3:53 pm

1 stop19h 43m

$755

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

jue. 3/12

7:10 am-5:35 am

2 stops20h 25m

Santiago Arturo Merino Benitez

jue. 3/26

8:10 am-11:42 pm

2 stops17h 32m

$757

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

mié. 3/11

5:00 pm-7:40 am

1 stop12h 40m

Santiago Arturo Merino Benitez

mié. 3/25

10:10 pm-5:53 pm

1 stop21h 43m

$757

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

lun. 3/9

3:58 pm-7:40 am

1 stop13h 42m

Santiago Arturo Merino Benitez

jue. 3/26

10:10 pm-5:53 pm

1 stop21h 43m

$757

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

dom. 3/8

5:15 pm-5:55 am

1 stop34h 40m

Santiago Arturo Merino Benitez

lun. 3/23

11:25 pm-3:53 pm

2 stops18h 28m

$757

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

mar. 3/10

1:00 pm-7:40 am

1 stop16h 40m

Santiago Arturo Merino Benitez

mar. 3/24

8:50 am-11:42 pm

2 stops16h 52m

$757

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/2

Showing 1-10 of 19 results
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Compare providers for flights from St. Louis to Santiago

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Santiago in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars
AranGrantPrice Accuracy2 starsTrust Score*3 stars
OvagoPrice Accuracy2 starsTrust Score*2 stars
CheapfaremartPrice Accuracy-Trust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on St. Louis-Santiago flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on St. Louis-Santiago flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from St. Louis-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on St. Louis-Santiago flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from St. Louis to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Santiago

How far ahead should I book a flight from St. Louis to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from St. Louis to Santiago. Price data was last updated on November 28, 2025.

To ensure you get the cheapest price possible for a flight from St. Louis to Santiago, you should look to book at least 62 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from St. Louis to Santiago?

Currently, December is the cheapest month in which you can book a flight from St. Louis to Santiago (average of $552). Flying from St. Louis to Santiago in October is currently the most expensive (average of $924). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from STL to SCL?

Find hourly flight availability from St. Louis to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated diciembre 4, 2025.

A simple way to save on the total cost of your ticket is to fly from St. Louis to Santiago in the evening. If you’re flexible enough to do this you can expect to save up to 19% on your trip compared to booking a flight in the morning.

How much does it cost to fly round-trip from St. Louis to Santiago?

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated diciembre 4, 2025.
Peruse reviews from past customers who have flown with Delta, LATAM Airlines, and United Airlines from St. Louis to Santiago to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,011 reviews

Comfort

7.9

Overall

7.9

Crew

8.5

Boarding

8.1

Food

7.3

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,011 reviews
Delta
7.9
Good
8,011 reviews

Comfort

7.9

Overall

7.9

Crew

8.5

Boarding

8.1

Food

7.3

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
LATAM Airlines
7.5
Good
1,889 reviews
Delta
7.9
Good
8,011 reviews

Comfort

7.9

Overall

7.9

Crew

8.5

Boarding

8.1

Food

7.3

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,063 reviews
Delta
7.9
Good
8,011 reviews

Comfort

7.9

Overall

7.9

Crew

8.5

Boarding

8.1

Food

7.3

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,043 reviews
Delta
7.9
Good
8,011 reviews

Comfort

7.9

Overall

7.9

Crew

8.5

Boarding

8.1

Food

7.3

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from St. Louis to Santiago?

    Airlines like Delta and United Airlines fly from St. Louis to Santiago in about 18h 25m. The time it takes to get you to your destination can typically vary by up to 4h 05m. The distance between St. Louis and Santiago is about 5137 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from St. Louis to Santiago round-trip?

    Flying on American Airlines is currently your cheapest option to Santiago, with prices starting at $689. Additional round-trip tickets that might be worth considering are offered by United Airlines and Delta, with the lowest prices starting at $764 and $803, respectively. These flights start at 30% lower than the current average price 3 months from now.

  • Can I find deals for flights from St. Louis to Santiago that include hotel bookings?

    Yes. In addition to deals on St. Louis to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Santiago.

  • Can I find deals for business class flights from St. Louis to Santiago?

    Yes. Cheapflights offers flight deals from St. Louis to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from St. Louis to Santiago?

    Currently, December is the cheapest month in which you can book a flight from St. Louis to Santiago (average of $552). Flying from St. Louis to Santiago in October is currently the most expensive (average of $924). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for St. Louis to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
Kansas City to Santiago flights
Springfield to Santiago flights
Kansas City to Balmaceda flights
St. Louis to Easter Island flights

Top 4 airlines flying from St. Louis to Santiago

Discover the top 4 airlines that operate flights from St. Louis to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated diciembre 4, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$689Average$992FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$764Average$1,047FlexibilityNo cancel feeOn-time69%
DeltaCheapest$803Average$1,003FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$823Average$908FlexibilityNo cancel feeOn-time81%

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