HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Santiago

$389+ Cheap flights from St. Louis (STL) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/16. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SCL
Apr 5 — Apr 121
Sun 4/5
Sun 4/12
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from St. Louis to Santiago with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from St. Louis to Santiago

Cheapest flights from St. Louis to Santiago
Explore the most affordable flight options available from St. Louis to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 6, 2026.

This LATAM Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/3112:04 pm
STL
-
SCL
2 stops15h 31m
LATAM Airlines
Tue 4/711:00 pm
SCL
-
STL
2 stops19h 53m
LATAM Airlines
Deal found 3/3$873
This LATAM Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/157:05 pm
STL
-
SCL
2 stops20h 20m
Multiple Airlines
Tue 10/64:10 am
SCL
-
STL
3 stops21h 17m
Multiple Airlines
Deal found 3/5$875
This American Airlines deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/152:33 pm
STL
-
SCL
2 stops15h 32m
American Airlines
Wed 4/228:35 pm
SCL
-
STL
2 stops19h 33m
American Airlines
Deal found 3/4$893
This American Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/202:33 pm
STL
-
SCL
2 stops15h 32m
American Airlines
Mon 4/278:35 pm
SCL
-
STL
2 stops18h 28m
American Airlines
Deal found 3/6$899
This LATAM Airlines deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/154:41 pm
STL
-
SCL
1 stop13h 34m
LATAM Airlines
Wed 4/228:40 pm
SCL
-
STL
1 stop12h 50m
LATAM Airlines
Deal found 3/4$902
This Delta deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/204:41 pm
STL
-
SCL
1 stop13h 34m
Delta
Mon 4/278:40 pm
SCL
-
STL
1 stop16h 16m
Delta
Deal found 3/6$908
This American Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1210:34 am
STL
-
SCL
2 stops20h 16m
American Airlines
Sat 9/269:30 pm
SCL
-
STL
2 stops19h 29m
American Airlines
Deal found 3/3$910
This LATAM Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/2011:42 am
STL
-
SCL
3 stops24h 43m
LATAM Airlines
Mon 4/275:40 am
SCL
-
STL
2 stops18h 56m
LATAM Airlines
Deal found 3/6$912
This American Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/172:12 pm
STL
-
SCL
2 stops15h 53m
American Airlines
Fri 4/248:35 pm
SCL
-
STL
2 stops17h 47m
American Airlines
Deal found 3/3$923

Find flight deals from St. Louis to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 6, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$873
(LATAM Airlines)

One-way from

$389
(Kiwi.com)

Popular in

January

Cheapest in

March

Average price

$833
Provider with most accurate pricing for Lambert-St Louis-Santiago Arturo Merino Benitez flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-Santiago Arturo Merino Benitez flights.
Search Deals
From Lambert-St Louis to Santiago Arturo Merino Benitez
Search Deals
One-way flight from Lambert-St Louis to Santiago Arturo Merino Benitez
Search Deals
Highest demand for flights based on searches. 16% potential increase in price ($206 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($66 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from St. Louis to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 6, 2026.
Use the filters below to find and compare flights from St. Louis to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Tue 3/31

12:04 pm-5:35 am

2 stops15h 31m

Santiago Arturo Merino Benitez

Tue 4/7

11:00 pm-5:53 pm

2 stops19h 53m

$873

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Mon 4/20

4:41 pm-7:15 am

1 stop13h 34m

Santiago Arturo Merino Benitez

Mon 4/27

8:40 pm-11:56 am

1 stop16h 16m

$908

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Fri 5/1

4:41 pm-2:05 pm

2 stops20h 24m

Santiago Arturo Merino Benitez

Sun 5/31

11:05 pm-5:56 pm

2 stops19h 51m

$985
Quickest round-trip

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Fri 4/17

4:41 pm-7:15 am

1 stop13h 34m

Santiago Arturo Merino Benitez

Fri 4/24

8:40 pm-8:30 am

1 stop12h 50m

$988

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Sun 3/22

4:05 pm-11:15 am

1 stop17h 10m

Santiago Arturo Merino Benitez

Wed 3/25

7:55 pm-3:29 pm

1 stop21h 34m

$1,020

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Sun 3/22

10:05 am-7:50 am

1 stop19h 45m

Santiago Arturo Merino Benitez

Wed 3/25

9:45 pm-9:21 am

1 stop13h 36m

$1,097

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Sun 3/22

7:03 am-6:25 am

2 stops21h 22m

Santiago Arturo Merino Benitez

Wed 3/25

6:40 am-11:58 pm

2 stops19h 18m

$1,097
Cheapest one-way

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Mon 3/16

8:10 pm-11:49 pm

2 stops49h 39m

$389

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Mon 3/16

4:05 pm-11:15 am

1 stop17h 10m

$410

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Sat 7/18

3:48 pm-9:05 pm

3 stops52h 17m

$472

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/3

Showing 1-10 of 15 resultsSorted by cheapest first
1
2

Compare providers for flights from St. Louis to Santiago

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Santiago in March.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
OvagoPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
AranGrantPrice Accuracy2 starsTrust Score*2 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on St. Louis-Santiago flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on St. Louis-Santiago flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from St. Louis-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on St. Louis-Santiago flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from St. Louis to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Santiago

What is the cheapest month to book a flight from St. Louis to Santiago?

Currently, March is the cheapest month in which you can book a flight from St. Louis to Santiago (average of $549). Flying from St. Louis to Santiago in June is currently the most expensive (average of $989). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated March 6, 2026.
Peruse reviews from past customers who have flown with Delta, LATAM Airlines, and American Airlines from St. Louis to Santiago to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,270 reviews

Comfort

7.9

Overall

7.9

Boarding

8.1

Crew

8.5

Entertainment

7.8

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,270 reviews
Delta
7.9
Good
8,270 reviews

Comfort

7.9

Overall

7.9

Boarding

8.1

Crew

8.5

Entertainment

7.8

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
LATAM Airlines
7.4
Good
1,917 reviews
Delta
7.9
Good
8,270 reviews

Comfort

7.9

Overall

7.9

Boarding

8.1

Crew

8.5

Entertainment

7.8

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.1
Good
11,399 reviews
Delta
7.9
Good
8,270 reviews

Comfort

7.9

Overall

7.9

Boarding

8.1

Crew

8.5

Entertainment

7.8

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from St. Louis to Santiago?

    Airlines like LATAM Airlines, Delta, and American Airlines fly from St. Louis to Santiago in about 12h 54m. The time it takes to get you to your destination can typically vary by up to 2h 59m. The distance between St. Louis and Santiago is about 5137 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from St. Louis to Santiago round-trip?

    Flying on Delta is currently your cheapest option to Santiago, with prices starting at $611. Additional round-trip tickets that might be worth considering are offered by American Airlines and LATAM Airlines, with the lowest prices starting at $689 and $803, respectively. These flights start at 41% lower than the current average price 3 months from now.

  • Can I find deals for flights from St. Louis to Santiago that include hotel bookings?

    Yes. In addition to deals on St. Louis to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Santiago.

  • Can I find deals for business class flights from St. Louis to Santiago?

    Yes. Cheapflights offers flight deals from St. Louis to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from St. Louis to Santiago?

    Currently, March is the cheapest month in which you can book a flight from St. Louis to Santiago (average of $549). Flying from St. Louis to Santiago in June is currently the most expensive (average of $989). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for St. Louis to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
St. Louis to Easter Island flights

Top 3 airlines flying from St. Louis to Santiago

Discover the top 3 airlines that operate flights from St. Louis to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 6, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$611Average$988FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$689Average$898FlexibilityNo cancel feeOn-time71%
LATAM AirlinesCheapest$803Average$913FlexibilityNo cancel feeOn-time81%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.