$360+ Cheap flights from St. Louis (STL) to Santiago (SCL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/10. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SCL
Sep 13 — Sep 201
Round-trip
1 adult, Economy
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Find cheap flights from St. Louis to Santiago with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from St. Louis to Santiago
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Best
Last-minute
One-way
Cheapest flights from St. Louis to SantiagoExplore the most affordable flight options available from St. Louis to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2026.
Explore the most affordable flight options available from St. Louis to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2026.
This Faresmojo deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Faresmojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/317:00 am -
1 stop22h 40m
Tue 11/1011:10 pm -
1 stop15h 05m
Deal found 8/13![JetBlue logo]()
$876
This Expedia deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/176:00 am -
1 stop22h 40m
Mon 12/79:50 pm -
1 stop16h 25m
Deal found 8/9![LATAM Airlines logo]()
$986
This LATAM Airlines deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2112:00 pm -
2 stops17h 00m
Wed 11/45:55 pm -
2 stops18h 22m
Deal found 8/9![LATAM Airlines logo]()
$995
This Delta deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/26:00 am -
2 stops21h 40m
Mon 9/78:40 pm -
1 stop19h 28m
Deal found 8/10![Delta logo]()
$997
This United Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/16:50 pm -
2 stops35h 00m
Thu 11/1210:45 pm -
2 stops21h 06m
Deal found 8/13![United Airlines logo]()
$1,000
This Delta deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/237:20 am -
1 stop21h 20m
Tue 1/128:13 am -
2 stops18h 26m
Deal found 8/9![Delta logo]()
$1,001
This American Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/210:22 am -
2 stops19h 43m
Mon 9/79:50 pm -
2 stops21h 00m
Deal found 8/11![American Airlines logo]()
$1,002
This Delta deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/17:00 am -
1 stop21h 40m
Thu 11/1211:10 pm -
1 stop17h 16m
Deal found 8/10![Delta logo]()
$1,016
This LATAM Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/111:00 am -
1 stop19h 15m
Sun 9/68:40 pm -
1 stop14h 40m
Deal found 8/10![LATAM Airlines logo]()
$1,017
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/282:11 pm -
1 stop15h 49m
Mon 10/59:30 pm -
1 stop22h 19m
Deal found 8/13![American Airlines logo]()
$1,021
This Mytrip deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/314:05 pm -
2 stops18h 35m
Tue 11/107:00 am -
3 stops35h 26m
Deal found 8/12![Multiple Airlines logo]()
$1,024
Best flights from St. Louis to SantiagoDiscover carefully curated flight deals from St. Louis to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 14, 2026.
Discover carefully curated flight deals from St. Louis to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 14, 2026.
This Faresmojo deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Faresmojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/317:00 am -
1 stop22h 40m
Tue 11/1011:10 pm -
1 stop15h 05m
Deal found 8/13![JetBlue logo]()
$876
This Delta deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/26:00 am -
2 stops21h 40m
Mon 9/78:40 pm -
1 stop19h 28m
Deal found 8/9![Delta logo]()
$997
This LATAM Airlines deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/16:00 am -
2 stops23h 00m
Sun 9/610:30 pm -
2 stops27h 28m
Deal found 8/9![LATAM Airlines logo]()
$997
This United Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/16:50 pm -
2 stops35h 00m
Thu 11/1210:45 pm -
2 stops21h 06m
Deal found 8/13![United Airlines logo]()
$1,000
This Delta deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/106:00 am -
2 stops21h 40m
Wed 9/168:40 pm -
1 stop14h 20m
Deal found 8/11![Delta logo]()
$997
This Delta deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/91:40 pm -
1 stop16h 35m
Wed 9/168:40 pm -
1 stop16h 15m
Deal found 8/10![Delta logo]()
$997
Last-minute flights from St. Louis to SantiagoDiscover last-minute flight deals from St. Louis to Santiago. Data last updated August 14, 2026 and is based on user searches.
Discover last-minute flight deals from St. Louis to Santiago. Data last updated August 14, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/283:25 pm -
2 stops14h 40m
Tue 9/18:50 pm -
2 stops17h 04m
Deal found 8/14![American Airlines logo]()
$1,038
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/2810:16 am -
2 stops19h 49m
Wed 9/28:50 pm -
2 stops21h 11m
Deal found 8/13![American Airlines logo]()
$1,052
This Delta deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/2812:52 pm -
2 stops24h 13m
Tue 9/18:40 pm -
1 stop16h 06m
Deal found 8/12![Delta logo]()
$1,058
This LATAM Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/111:00 am -
1 stop19h 15m
Sun 9/68:40 pm -
1 stop14h 40m
Deal found 8/10![LATAM Airlines logo]()
$1,017
This Delta deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/26:00 am -
2 stops21h 40m
Mon 9/78:40 pm -
1 stop19h 28m
Deal found 8/10![Delta logo]()
$997
This American Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/210:22 am -
2 stops19h 43m
Mon 9/79:50 pm -
2 stops21h 00m
Deal found 8/11![American Airlines logo]()
$1,002
This oojo deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/211:00 am -
2 stops16h 40m
Mon 9/79:30 am -
3 stops26h 04m
Deal found 8/10![LATAM Airlines logo]()
$1,048
This Orbitz deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/93:40 pm -
3 stops20h 45m
Wed 9/169:30 am -
3 stops27h 25m
Deal found 8/10![LATAM Airlines logo]()
$1,033
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/282:11 pm -
1 stop15h 49m
Mon 10/59:30 pm -
1 stop22h 19m
Deal found 8/13![American Airlines logo]()
$1,021
One-way flights from St. Louis to SantiagoSearch for one-way flight options from St. Louis to Santiago. Find affordable one-way fares based on user searches. Data last updated August 14, 2026.
Search for one-way flight options from St. Louis to Santiago. Find affordable one-way fares based on user searches. Data last updated August 14, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/106:39 pm -
3 stops34h 16m
Deal found 8/11![Multiple Airlines logo]()
$360
This Kiwi.com deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/1512:17 pm -
3 stops36h 29m
Deal found 8/12![Multiple Airlines logo]()
$389
This Kiwi.com deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/26:45 pm -
3 stops41h 50m
Deal found 8/10![Multiple Airlines logo]()
$402
This Mytrip deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/84:05 pm -
2 stops27h 30m
Deal found 8/11![Multiple Airlines logo]()
$497
This Faresmojo deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Faresmojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/103:40 pm -
1 stop14h 35m
Deal found 8/11![JetBlue logo]()
$538
This oojo deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/246:00 am -
2 stops23h 55m
Deal found 8/10![LATAM Airlines logo]()
$660
This Delta deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/249:15 am -
1 stop21h 00m
Deal found 8/10![Delta logo]()
$666
This SmartFares deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/152:30 pm -
1 stop15h 45m
Deal found 8/12![LATAM Airlines logo]()
$668
This Delta deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/1510:05 am -
2 stops17h 35m
Deal found 8/12![Delta logo]()
$688
This Avianca deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/246:54 pm -
2 stops18h 21m
Deal found 8/11![Multiple Airlines logo]()
$690
Find flight deals from St. Louis to Santiago
Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 14, 2026.
Most accurate provider | Ovago 3 stars |
|---|---|
Most trusted provider | Ovago 3 stars |
Round-trip from | $876 (Faresmojo) |
One-way from | $360 (Kiwi.com) |
Popular in | January |
Cheapest in | March |
Average price | $1,267 |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2026.
Use the filters below to find and compare flights from St. Louis to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisSantiago
STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez
STLSCL
Lambert-St Louis
Sat 10/31
7:00 am-7:40 am
1 stop22h 40m
Santiago Arturo Merino Benitez
Tue 11/10
11:10 pm-11:15 am
1 stop15h 05m
$876
St. LouisSantiago
STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez
STLSCL
Lambert-St Louis
Wed 9/2
6:00 am-4:40 am
2 stops21h 40m
Santiago Arturo Merino Benitez
Mon 9/7
8:40 pm-2:08 pm
1 stop19h 28m
$997
St. LouisSantiago
STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez
STLSCL
Lambert-St Louis
Tue 9/1
6:00 am-6:00 am
2 stops23h 00m
Santiago Arturo Merino Benitez
Sun 9/6
10:30 pm-11:58 pm
2 stops27h 28m
$997
St. LouisSantiago
STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez
STLSCL
Lambert-St Louis
Thu 9/10
6:00 am-5:40 am
2 stops21h 40m
Santiago Arturo Merino Benitez
Wed 9/16
8:40 pm-9:00 am
1 stop14h 20m
$997
Quickest round-trip
St. LouisSantiago
STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez
STLSCL
Lambert-St Louis
Wed 9/9
1:40 pm-8:15 am
1 stop16h 35m
Santiago Arturo Merino Benitez
Wed 9/16
8:40 pm-10:55 am
1 stop16h 15m
$997
St. LouisSantiago
STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez
STLSCL
Lambert-St Louis
Sun 11/1
6:50 pm-8:50 am
2 stops35h 00m
Santiago Arturo Merino Benitez
Thu 11/12
10:45 pm-4:51 pm
2 stops21h 06m
$1,000
Cheapest one-way
St. LouisSantiago
STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez
STLSCL
Lambert-St Louis
Thu 9/10
6:39 pm-6:55 am
3 stops34h 16m
$360
St. LouisSantiago
STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez
STLSCL
Lambert-St Louis
Tue 12/8
4:05 pm-10:35 pm
2 stops27h 30m
$497
Quickest one-way
St. LouisSantiago
STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez
STLSCL
Lambert-St Louis
Thu 9/10
3:40 pm-8:15 am
1 stop14h 35m
$538
St. LouisSantiago
STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez
STLSCL
Lambert-St Louis
Mon 8/24
6:00 am-6:55 am
2 stops23h 55m
$660
Showing 1-10 of 13 resultsSorted by cheapest first
Compare providers for flights from St. Louis to Santiago
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Santiago in August.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on St. Louis-Santiago flights, users find the pricing of Ovago to be most consistent on Cheapflights vs. Ovago Users can find the same prices on St. Louis-Santiago flight deals on Cheapflights vs. Ovago >95% of the time. Price accuracy is based on data collected from St. Louis-Santiago flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on St. Louis-Santiago flights, Cheapflights users trust Ovago the most. Ovago has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from St. Louis to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from St. Louis with our price prediction graph.
STL-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to Santiago
What is the cheapest month to book a flight from St. Louis to Santiago?
Currently, March is the cheapest month in which you can book a flight from St. Louis to Santiago (average of $823). Flying from St. Louis to Santiago in January is currently the most expensive (average of $1,948). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from St. Louis to Santiago?
Airfare is below average for this route at the moment.
St. Louis to Santiago flights typically cost between $1,234 and $1,382 in October.The cheapest round-trip price found within the last 5 days was $876 on JetBlue (Oct 31-Nov 10).
Reviews of airlines servicing Santiago
Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated August 14, 2026.
Peruse reviews from past customers who have flown with Delta,LATAM Airlines, andAmerican Airlines from St. Louis to Santiago to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.2
Boarding
8.1
Entertainment
7.8
Comfort
7.8
Crew
8.5
Overall
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Food
7.2
Boarding
8.1
Entertainment
7.8
Comfort
7.8
Crew
8.5
Overall
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Food
7.2
Boarding
8.1
Entertainment
7.8
Comfort
7.8
Crew
8.5
Overall
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Food
7.2
Boarding
8.1
Entertainment
7.8
Comfort
7.8
Crew
8.5
Overall
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from St. Louis to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Alternative routes for St. Louis to Santiago
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Complete your trip
Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from St. Louis to Santiago, based on your preferred cabin class, be it economy, premium economy, business, or first class.
St. Louis and Santiago flights
Browse other St. Louis and Santiago flight options. Last updated on August 14, 2026.
Other flights from St. Louis
Browse through other flights departing from St. Louis. Flights are based on user searches made on Cheapflights and were last updated on August 14, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on August 14, 2026.
Top 3 airlines flying from St. Louis to Santiago
Discover the top 3 airlines that operate flights from St. Louis to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$611 | Average$1,175 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$689 | Average$898 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$792 | Average$1,013 | FlexibilityNo cancel fee | On-time81% |