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$820+ Cheap flights from St. Louis (STL) to Santiago (SCL)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/5. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SCL
Apr 20 — Apr 271
Mon 4/20
Mon 4/27
1 adult, Economy
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Cheap flight deals from St. Louis to Santiago

Cheapest flights from St. Louis to Santiago
Explore the most affordable flight options available from St. Louis to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 21, 2026.

This American Airlines deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/52:33 pm
STL
-
SCL
2 stops15h 32m
American Airlines
Tue 5/128:35 pm
SCL
-
STL
1 stop14h 41m
American Airlines
Deal found 3/20$820
This Delta deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/56:50 pm
STL
-
SCL
2 stops18h 15m
Delta
Tue 5/127:55 pm
SCL
-
STL
2 stops17h 25m
Delta
Deal found 3/20$875
This LATAM Airlines deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/511:42 am
STL
-
SCL
3 stops22h 07m
LATAM Airlines
Tue 5/127:50 am
SCL
-
STL
2 stops17h 09m
LATAM Airlines
Deal found 3/20$880
This Delta deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/149:00 am
STL
-
SCL
1 stop21h 15m
Delta
Wed 11/411:10 pm
SCL
-
STL
1 stop16h 46m
Delta
Deal found 3/17$925
This American Airlines deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/812:43 pm
STL
-
SCL
2 stops17h 07m
American Airlines
Wed 9/309:30 pm
SCL
-
STL
2 stops20h 39m
American Airlines
Deal found 3/16$930
This American Airlines deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/3012:27 pm
STL
-
SCL
2 stops17h 38m
American Airlines
Thu 5/78:35 pm
SCL
-
STL
1 stop14h 41m
American Airlines
Deal found 3/16$940
This Billigflug deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Billigflug is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/36:50 pm
STL
-
SCL
2 stops34h 10m
LATAM Airlines
Sun 5/1011:05 pm
SCL
-
STL
2 stops25h 54m
LATAM Airlines
Deal found 3/19$942
This Orbitz deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/141:30 pm
STL
-
SCL
1 stop16h 45m
LATAM Airlines
Wed 11/412:10 am
SCL
-
STL
1 stop13h 38m
LATAM Airlines
Deal found 3/17$946
This Delta deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/134:41 pm
STL
-
SCL
1 stop13h 34m
Delta
Mon 4/208:40 pm
SCL
-
STL
1 stop12h 50m
Delta
Deal found 3/16$958

Find flight deals from St. Louis to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 21, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$820
(American Airlines)

Popular in

January

Cheapest in

March

Average price

$833
Provider with most accurate pricing for Lambert-St Louis-Santiago Arturo Merino Benitez flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-Santiago Arturo Merino Benitez flights.
Search Deals
From Lambert-St Louis to Santiago Arturo Merino Benitez
Search Deals
Highest demand for flights based on searches. 16% potential increase in price ($206 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($66 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from St. Louis to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 21, 2026.
Use the filters below to find and compare flights from St. Louis to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Tue 5/5

11:42 am-7:15 am

1 stop18h 33m

Santiago Arturo Merino Benitez

Tue 5/12

10:55 pm-5:05 pm

1 stop19h 10m

$875

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Sun 5/3

6:50 pm-6:00 am

2 stops34h 10m

Santiago Arturo Merino Benitez

Sun 5/10

11:05 pm-11:59 pm

2 stops25h 54m

$942
Quickest round-trip

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Mon 4/13

4:41 pm-7:15 am

1 stop13h 34m

Santiago Arturo Merino Benitez

Mon 4/20

8:40 pm-8:30 am

1 stop12h 50m

$958

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Mon 4/13

4:41 pm-7:15 am

1 stop13h 34m

Santiago Arturo Merino Benitez

Mon 4/20

8:40 pm-10:34 am

1 stop14h 54m

$958

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Tue 9/8

10:55 am-2:05 pm

2 stops25h 10m

Santiago Arturo Merino Benitez

Wed 9/30

12:35 pm-11:27 pm

3 stops36h 52m

$975

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Fri 7/3

11:51 am-6:00 am

2 stops17h 09m

Santiago Arturo Merino Benitez

Sat 7/11

11:05 pm-6:02 pm

2 stops19h 57m

$1,109

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Fri 7/3

11:51 am-6:00 am

2 stops17h 09m

Santiago Arturo Merino Benitez

Sat 7/11

10:55 pm-4:55 pm

1 stop19h 00m

$1,125

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/20

Sorted by cheapest first

Compare providers for flights from St. Louis to Santiago

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Santiago in March.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
OvagoPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
AranGrantPrice Accuracy2 starsTrust Score*2 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on St. Louis-Santiago flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on St. Louis-Santiago flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from St. Louis-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on St. Louis-Santiago flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from St. Louis to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Santiago

What is the cheapest month to book a flight from St. Louis to Santiago?

Currently, March is the cheapest month in which you can book a flight from St. Louis to Santiago (average of $549). Flying from St. Louis to Santiago in June is currently the most expensive (average of $989). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from St. Louis to Santiago?

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated March 21, 2026.
Peruse reviews from past customers who have flown with Delta,LATAM Airlines, andAmerican Airlines from St. Louis to Santiago to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,313 reviews

Entertainment

7.8

Comfort

7.9

Food

7.2

Boarding

8.1

Overall

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,313 reviews
Delta
7.9
Good
8,313 reviews

Entertainment

7.8

Comfort

7.9

Food

7.2

Boarding

8.1

Overall

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
LATAM Airlines
7.4
Good
1,917 reviews
Delta
7.9
Good
8,313 reviews

Entertainment

7.8

Comfort

7.9

Food

7.2

Boarding

8.1

Overall

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.1
Good
11,487 reviews
Delta
7.9
Good
8,313 reviews

Entertainment

7.8

Comfort

7.9

Food

7.2

Boarding

8.1

Overall

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from St. Louis to Santiago?

    Airlines like Delta and LATAM Airlines fly from St. Louis to Santiago in about 18h 33m. The time it takes to get you to your destination can typically vary by up to 15h 37m. The distance between St. Louis and Santiago is about 5137 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from St. Louis to Santiago round-trip?

    Flying on Delta is currently your cheapest option to Santiago, with prices starting at $611. Additional round-trip tickets that might be worth considering are offered by American Airlines and LATAM Airlines, with the lowest prices starting at $689 and $803, respectively. These flights start at 41% lower than the current average price 3 months from now.

  • Can I find deals for flights from St. Louis to Santiago that include hotel bookings?

    Yes. In addition to deals on St. Louis to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Santiago.

  • Can I find deals for business class flights from St. Louis to Santiago?

    Yes. Cheapflights offers flight deals from St. Louis to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from St. Louis to Santiago?

    Currently, March is the cheapest month in which you can book a flight from St. Louis to Santiago (average of $549). Flying from St. Louis to Santiago in June is currently the most expensive (average of $989). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for St. Louis to Santiago

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Top 3 airlines flying from St. Louis to Santiago

Discover the top 3 airlines that operate flights from St. Louis to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 21, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$611Average$1,003FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$689Average$898FlexibilityNo cancel feeOn-time71%
LATAM AirlinesCheapest$803Average$898FlexibilityNo cancel feeOn-time81%

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