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$351+ Cheap flights from St. Louis (STL) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/11. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SCL
Aug 30 — Sep 61
Sun 8/30
Sun 9/6
1 adult, Economy
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Cheap flight deals from St. Louis to Santiago

Cheapest flights from St. Louis to Santiago
Explore the most affordable flight options available from St. Louis to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 31, 2026.

This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/95:00 am
STL
-
SCL
1 stop25h 00m
American Airlines
Mon 11/1610:15 pm
SCL
-
STL
1 stop26h 32m
American Airlines
Deal found 7/27$990
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/211:35 am
STL
-
SCL
1 stop18h 30m
American Airlines
Mon 9/79:50 pm
SCL
-
STL
1 stop14h 49m
American Airlines
Deal found 7/26$997
This LATAM Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/910:40 am
STL
-
SCL
3 stops23h 09m
LATAM Airlines
Mon 11/168:40 am
SCL
-
STL
2 stops15h 53m
LATAM Airlines
Deal found 7/27$1,000
This Expedia deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/236:59 pm
STL
-
SCL
1 stop32h 41m
LATAM Airlines
Tue 12/299:50 pm
SCL
-
STL
1 stop15h 58m
LATAM Airlines
Deal found 7/29$1,005
This Delta deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/211:00 am
STL
-
SCL
1 stop19h 15m
Delta
Mon 9/78:40 pm
SCL
-
STL
1 stop21h 14m
Delta
Deal found 7/29$1,007
This LATAM Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/182:31 pm
STL
-
SCL
3 stops20h 54m
LATAM Airlines
Tue 12/1511:10 pm
SCL
-
STL
2 stops20h 22m
LATAM Airlines
Deal found 7/27$1,010
This LATAM Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/211:00 am
STL
-
SCL
3 stops25h 25m
LATAM Airlines
Mon 9/78:55 pm
SCL
-
STL
2 stops17h 37m
LATAM Airlines
Deal found 7/26$1,012
This United Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2811:00 am
STL
-
SCL
1 stop18h 50m
United Airlines
Sun 11/110:45 pm
SCL
-
STL
1 stop22h 53m
United Airlines
Deal found 7/28$1,017
This LATAM Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/111:00 am
STL
-
SCL
1 stop19h 15m
LATAM Airlines
Sun 9/68:40 pm
SCL
-
STL
1 stop14h 40m
LATAM Airlines
Deal found 7/30$1,027

Find flight deals from St. Louis to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 31, 2026.

Most accurate provider

Ovago
3 stars

Most trusted provider

Ovago
3 stars

Round-trip from

$990
(American Airlines)

One-way from

$351
(Kiwi.com)

Popular in

January

Cheapest in

March

Average price

$1,055
Provider with most accurate pricing for Lambert-St Louis-Santiago Arturo Merino Benitez flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-Santiago Arturo Merino Benitez flights.
Search Deals
From Lambert-St Louis to Santiago Arturo Merino Benitez
Search Deals
One-way flight from Lambert-St Louis to Santiago Arturo Merino Benitez
Search Deals
Highest demand for flights based on searches. 10% potential increase in price ($146 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($68 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from St. Louis to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 31, 2026.
Use the filters below to find and compare flights from St. Louis to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 11/18

8:30 am-8:50 am

1 stop21h 20m

Santiago Arturo Merino Benitez

Tue 12/15

10:45 pm-4:44 pm

1 stop20h 59m

$995

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 9/9

10:40 am-11:49 am

3 stops23h 09m

Santiago Arturo Merino Benitez

Mon 11/16

8:40 am-9:33 pm

2 stops15h 53m

$1,000

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 9/2

11:00 am-7:15 am

1 stop19h 15m

Santiago Arturo Merino Benitez

Mon 9/7

8:40 pm-3:54 pm

1 stop21h 14m

$1,007

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 10/28

2:25 pm-5:30 pm

2 stops25h 05m

Santiago Arturo Merino Benitez

Sun 11/1

5:00 pm-4:28 pm

2 stops26h 28m

$1,007

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 9/2

6:00 am-6:00 am

2 stops23h 00m

Santiago Arturo Merino Benitez

Mon 9/7

8:55 pm-12:32 pm

2 stops17h 37m

$1,007

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Tue 9/1

6:00 am-6:00 am

2 stops23h 00m

Santiago Arturo Merino Benitez

Sun 9/6

10:30 pm-11:58 pm

2 stops27h 28m

$1,007
Quickest round-trip

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 10/28

1:08 pm-7:50 am

2 stops16h 42m

Santiago Arturo Merino Benitez

Sun 11/1

10:45 pm-10:02 am

1 stop14h 17m

$1,017
Cheapest one-way

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 11/11

10:35 am-10:35 pm

3 stops33h 00m

$351
Quickest one-way

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 11/11

5:00 pm-9:00 am

1 stop13h 00m

$658

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 11/11

2:55 pm-8:50 am

1 stop14h 55m

$658

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/26

Showing 1-10 of 14 resultsSorted by cheapest first
1
2

Compare providers for flights from St. Louis to Santiago

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Santiago in July.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
OvagoPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on St. Louis-Santiago flights, users find the pricing of Ovago to be most consistent on Cheapflights vs. Ovago Users can find the same prices on St. Louis-Santiago flight deals on Cheapflights vs. Ovago >95% of the time. Price accuracy is based on data collected from St. Louis-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on St. Louis-Santiago flights, Cheapflights users trust Ovago the most. Ovago has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from St. Louis to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Santiago

What is the cheapest month to book a flight from St. Louis to Santiago?

Currently, March is the cheapest month in which you can book a flight from St. Louis to Santiago (average of $823). Flying from St. Louis to Santiago in January is currently the most expensive (average of $1,948). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated July 31, 2026.
Peruse reviews from past customers who have flown with Delta,LATAM Airlines, andAmerican Airlines from St. Louis to Santiago to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.8
Good
8,494 reviews

Entertainment

7.8

Comfort

7.8

Boarding

8.1

Crew

8.5

Food

7.2

Overall

7.8

Reviews

1 / 20
10.0
Excellent

Anonymous,May 2026

SEA - KOA

The snacks were not very good, not everyone was very friendly and professional
Delta
7.8
Good
8,494 reviews
Delta
7.8
Good
8,494 reviews

Entertainment

7.8

Comfort

7.8

Boarding

8.1

Crew

8.5

Food

7.2

Overall

7.8

Reviews

1 / 20
10.0
Excellent

Anonymous,May 2026

SEA - KOA

The snacks were not very good, not everyone was very friendly and professional
LATAM Airlines
7.4
Good
1,967 reviews
Delta
7.8
Good
8,494 reviews

Entertainment

7.8

Comfort

7.8

Boarding

8.1

Crew

8.5

Food

7.2

Overall

7.8

Reviews

1 / 20
10.0
Excellent

Anonymous,May 2026

SEA - KOA

The snacks were not very good, not everyone was very friendly and professional
American Airlines
7.1
Good
11,846 reviews
Delta
7.8
Good
8,494 reviews

Entertainment

7.8

Comfort

7.8

Boarding

8.1

Crew

8.5

Food

7.2

Overall

7.8

Reviews

1 / 20
10.0
Excellent

Anonymous,May 2026

SEA - KOA

The snacks were not very good, not everyone was very friendly and professional

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from St. Louis to Santiago?

    Airlines like United Airlines, LATAM Airlines, and Delta fly from St. Louis to Santiago in about 19h 15m. The time it takes to get you to your destination can typically vary by up to 3h 54m. The distance between St. Louis and Santiago is about 5137 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from St. Louis to Santiago round-trip?

    Flying on Delta is currently your cheapest option to Santiago, with prices starting at $611. Additional round-trip tickets that might be worth considering are offered by American Airlines and LATAM Airlines, with the lowest prices starting at $689 and $792, respectively. These flights start at 49% lower than the current average price 3 months from now.

  • Can I find deals for flights from St. Louis to Santiago that include hotel bookings?

    Yes. In addition to deals on St. Louis to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Santiago.

  • Can I find deals for business class flights from St. Louis to Santiago?

    Yes. Cheapflights offers flight deals from St. Louis to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from St. Louis to Santiago?

    Currently, March is the cheapest month in which you can book a flight from St. Louis to Santiago (average of $823). Flying from St. Louis to Santiago in January is currently the most expensive (average of $1,948). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for St. Louis to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from St. Louis to Santiago

Discover the top 3 airlines that operate flights from St. Louis to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 31, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$611Average$1,125FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$689Average$894FlexibilityNo cancel feeOn-time71%
LATAM AirlinesCheapest$792Average$1,013FlexibilityNo cancel feeOn-time81%

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