$427+ Cheap flights from St. Louis (STL) to Santiago (SCL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/30. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SCL
Jun 10 — Jun 171
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from St. Louis to Santiago with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from St. Louis to Santiago
Cheapest
Best
Last-minute
One-way
Cheapest flights from St. Louis to SantiagoExplore the most affordable flight options available from St. Louis to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 11, 2026.
Explore the most affordable flight options available from St. Louis to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 11, 2026.
This KAYAK deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/111:51 am
STL
- SCL
2 stops14h 44m
LATAM Airlines
Thu 12/1011:55 pm
SCL
- STL
1 stop20h 11m
LATAM Airlines
Deal found 5/6![LATAM Airlines logo]()
$920
This American Airlines deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/14:21 pm
STL
- SCL
1 stop13h 39m
American Airlines
Thu 12/1011:45 pm
SCL
- STL
1 stop15h 47m
American Airlines
Deal found 5/6![American Airlines logo]()
$925
This Orbitz deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/14:40 pm
STL
- SCL
1 stop12h 00m
LATAM Airlines
Thu 12/1012:55 am
SCL
- STL
1 stop19h 11m
LATAM Airlines
Deal found 5/6![LATAM Airlines logo]()
$956
This United Airlines deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/711:00 am
STL
- SCL
1 stop18h 50m
United Airlines
Thu 12/1010:45 pm
SCL
- STL
1 stop13h 57m
United Airlines
Deal found 5/7![United Airlines logo]()
$975
This KAYAK deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/164:40 pm
STL
- SCL
1 stop12h 00m
LATAM Airlines
Sun 12/611:25 pm
SCL
- STL
2 stops21h 36m
LATAM Airlines
Deal found 5/7![LATAM Airlines logo]()
$985
This United Airlines deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/88:15 pm
STL
- SCL
2 stops33h 35m
United Airlines
Mon 11/3010:45 pm
SCL
- STL
2 stops40h 35m
United Airlines
Deal found 5/8![United Airlines logo]()
$997
This Travelocity deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/94:40 pm
STL
- SCL
1 stop12h 00m
LATAM Airlines
Mon 11/3012:10 am
SCL
- STL
1 stop20h 51m
LATAM Airlines
Deal found 5/10![LATAM Airlines logo]()
$1,006
This Orbitz deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/166:59 pm
STL
- SCL
2 stops19h 26m
LATAM Airlines
Sun 12/612:25 am
SCL
- STL
2 stops20h 36m
LATAM Airlines
Deal found 5/7![LATAM Airlines logo]()
$1,016
Best flights from St. Louis to SantiagoDiscover carefully curated flight deals from St. Louis to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 11, 2026.
Discover carefully curated flight deals from St. Louis to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 11, 2026.
This KAYAK deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/310:51 am
STL
- SCL
2 stops18h 09m
LATAM Airlines
Sat 7/1111:05 pm
SCL
- STL
2 stops25h 48m
LATAM Airlines
Deal found 5/7![LATAM Airlines logo]()
$1,219
This United Airlines deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/17:00 am
STL
- SCL
2 stops20h 59m
United Airlines
Sat 9/53:27 am
SCL
- STL
2 stops32h 43m
United Airlines
Deal found 5/9![United Airlines logo]()
$1,228
This Delta deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/33:57 pm
STL
- SCL
1 stop14h 18m
Delta
Sat 7/118:40 pm
SCL
- STL
1 stop19h 08m
Delta
Deal found 5/6![Delta logo]()
$1,235
This Delta deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/249:21 am
STL
- SCL
1 stop20h 54m
Delta
Wed 7/18:40 pm
SCL
- STL
1 stop16h 54m
Delta
Deal found 5/9![Delta logo]()
$1,285
Last-minute flights from St. Louis to SantiagoDiscover last-minute flight deals from St. Louis to Santiago. Data last updated May 11, 2026 and is based on user searches.
Discover last-minute flight deals from St. Louis to Santiago. Data last updated May 11, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/274:19 pm
STL
- SCL
2 stops36h 41m
Multiple Airlines
Sun 6/79:30 am
SCL
- STL
1 stop30h 09m
Multiple Airlines
Deal found 5/6![Multiple Airlines logo]()
$1,176
This KAYAK deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2710:49 am
STL
- SCL
2 stops17h 01m
LATAM Airlines
Sun 6/711:05 pm
SCL
- STL
2 stops20h 02m
LATAM Airlines
Deal found 5/6![LATAM Airlines logo]()
$1,287
This Kiwi.com deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/54:19 pm
STL
- SCL
2 stops50h 04m
Multiple Airlines
Sun 6/149:30 am
SCL
- STL
1 stop30h 07m
Multiple Airlines
Deal found 5/8![Multiple Airlines logo]()
$1,202
This KAYAK deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/51:27 pm
STL
- SCL
2 stops16h 28m
LATAM Airlines
Sat 6/135:40 am
SCL
- STL
2 stops19h 06m
LATAM Airlines
Deal found 5/8![LATAM Airlines logo]()
$1,327
This Kiwi.com deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/216:30 am
STL
- SCL
1 stop13h 40m
Multiple Airlines
Sun 6/2811:05 pm
SCL
- STL
2 stops25h 44m
Multiple Airlines
Deal found 5/7![Multiple Airlines logo]()
$1,313
This American Airlines deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/2111:04 am
STL
- SCL
1 stop19h 01m
American Airlines
Sun 6/289:00 pm
SCL
- STL
1 stop14h 35m
American Airlines
Deal found 5/7![American Airlines logo]()
$1,325
This Ovago deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/248:35 am
STL
- SCL
2 stops19h 28m
Copa Airlines
Tue 6/302:27 am
SCL
- STL
2 stops21h 18m
Copa Airlines
Deal found 5/9![Copa Airlines logo]()
$1,273
This Delta deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/247:12 pm
STL
- SCL
2 stops17h 53m
Delta
Wed 7/18:40 pm
SCL
- STL
1 stop19h 12m
Delta
Deal found 5/9![Delta logo]()
$1,285
This Expedia deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/241:39 pm
STL
- SCL
3 stops22h 46m
LATAM Airlines
Wed 7/17:50 am
SCL
- STL
2 stops17h 06m
LATAM Airlines
Deal found 5/9![LATAM Airlines logo]()
$1,321
One-way flights from St. Louis to SantiagoSearch for one-way flight options from St. Louis to Santiago. Find affordable one-way fares based on user searches. Data last updated May 11, 2026.
Search for one-way flight options from St. Louis to Santiago. Find affordable one-way fares based on user searches. Data last updated May 11, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/306:33 pm
STL
- SCL
3 stops33h 30m
Multiple Airlines
Deal found 5/8![Multiple Airlines logo]()
$427
This Kiwi.com deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/314:52 pm
STL
- SCL
3 stops52h 51m
Multiple Airlines
Deal found 5/8![Multiple Airlines logo]()
$456
This Kiwi.com deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/14:52 pm
STL
- SCL
3 stops34h 03m
Multiple Airlines
Deal found 5/8![Multiple Airlines logo]()
$466
This Kiwi.com deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/278:08 pm
STL
- SCL
3 stops46h 15m
Multiple Airlines
Deal found 5/9![Multiple Airlines logo]()
$544
This Delta deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/249:17 am
STL
- SCL
1 stop20h 58m
Delta
Deal found 5/6![Delta logo]()
$608
This KAYAK deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/246:00 am
STL
- SCL
3 stops30h 25m
LATAM Airlines
Deal found 5/6![LATAM Airlines logo]()
$624
This American Airlines deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/2411:35 am
STL
- SCL
1 stop18h 15m
American Airlines
Deal found 5/10![American Airlines logo]()
$628
Find flight deals from St. Louis to Santiago
Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 11, 2026.
Most accurate provider | Ovago 3 stars |
|---|---|
Most trusted provider | Ovago 3 stars |
Round-trip from | $1,176 (Kiwi.com) |
One-way from | $427 (Kiwi.com) |
Popular in | January |
Cheapest in | March |
Average price | $1,088 |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 11, 2026.
Use the filters below to find and compare flights from St. Louis to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Fri 7/3
10:51 am-6:00 am
2 stops18h 09m
Santiago Arturo Merino Benitez
Sat 7/11
11:05 pm-11:53 pm
2 stops25h 48m
$1,219
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Tue 9/1
7:00 am-4:59 am
2 stops20h 59m
Santiago Arturo Merino Benitez
Sat 9/5
3:27 am-10:10 am
2 stops32h 43m
$1,228
Quickest round-trip
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Fri 7/3
3:57 pm-7:15 am
1 stop14h 18m
Santiago Arturo Merino Benitez
Sat 7/11
8:40 pm-2:48 pm
1 stop19h 08m
$1,235
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Wed 6/24
9:21 am-7:15 am
1 stop20h 54m
Santiago Arturo Merino Benitez
Wed 7/1
8:40 pm-12:34 pm
1 stop16h 54m
$1,285
Cheapest one-way
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Wed 5/27
8:08 pm-7:23 pm
3 stops46h 15m
$544
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Mon 8/24
6:00 am-4:50 am
2 stops21h 50m
$608
Quickest one-way
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Mon 8/24
10:16 am-6:50 am
2 stops19h 34m
$628
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Mon 8/24
6:00 am-1:25 pm
3 stops30h 25m
$643
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Thu 7/30
7:08 am-7:15 am
1 stop23h 07m
$649
Sorted by cheapest first
Compare providers for flights from St. Louis to Santiago
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Santiago in May.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on St. Louis-Santiago flights, users find the pricing of Ovago to be most consistent on Cheapflights vs. Ovago Users can find the same prices on St. Louis-Santiago flight deals on Cheapflights vs. Ovago >95% of the time. Price accuracy is based on data collected from St. Louis-Santiago flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on St. Louis-Santiago flights, Cheapflights users trust Ovago the most. Ovago has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from St. Louis to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from St. Louis with our price prediction graph.
STL-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to Santiago
What is the cheapest month to book a flight from St. Louis to Santiago?
Currently, March is the cheapest month in which you can book a flight from St. Louis to Santiago (average of $793). Flying from St. Louis to Santiago in January is currently the most expensive (average of $1,852). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from St. Louis to Santiago?
Reviews of airlines servicing Santiago
Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated May 11, 2026.
Peruse reviews from past customers who have flown with Delta,LATAM Airlines, andAmerican Airlines from St. Louis to Santiago to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.2
Crew
8.5
Boarding
8.1
Comfort
7.8
Entertainment
7.8
Overall
7.9
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Food
7.2
Crew
8.5
Boarding
8.1
Comfort
7.8
Entertainment
7.8
Overall
7.9
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Food
7.2
Crew
8.5
Boarding
8.1
Comfort
7.8
Entertainment
7.8
Overall
7.9
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Food
7.2
Crew
8.5
Boarding
8.1
Comfort
7.8
Entertainment
7.8
Overall
7.9
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from St. Louis to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Other flights from St. Louis
Popular flights
Santiago flight routes
Alternative routes for St. Louis to Santiago
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from St. Louis to Santiago by cabin class
Find flights from St. Louis to Santiago, based on your preferred cabin class, be it economy, premium economy, business, or first class.
St. Louis and Santiago flights
Browse other St. Louis and Santiago flight options. Last updated on May 11, 2026.
Other flights from St. Louis
Browse through other flights departing from St. Louis. Flights are based on user searches made on Cheapflights and were last updated on May 11, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on May 11, 2026.
Top 3 airlines flying from St. Louis to Santiago
Discover the top 3 airlines that operate flights from St. Louis to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 11, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$611 | Average$1,083 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$689 | Average$894 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$792 | Average$883 | FlexibilityNo cancel fee | On-time81% |