Santiago

$479+ Cheap flights from St. Louis (STL) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/10. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SCL
Jul 21 — Jul 281
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Cheap flight deals from St. Louis to Santiago

Cheapest flights from St. Louis to Santiago
Explore the most affordable flight options available from St. Louis to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 21, 2026.

This American Airlines deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/111:35 am
STL
-
SCL
1 stop17h 50m
American Airlines
Sun 9/69:50 pm
SCL
-
STL
1 stop14h 55m
American Airlines
Deal found 6/20$947
This LATAM Airlines deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/26:00 am
STL
-
SCL
3 stops27h 49m
LATAM Airlines
Mon 9/74:30 pm
SCL
-
STL
2 stops33h 12m
LATAM Airlines
Deal found 6/20$957
This LATAM Airlines deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/112:52 pm
STL
-
SCL
3 stops23h 33m
LATAM Airlines
Sun 9/69:30 pm
SCL
-
STL
2 stops28h 28m
LATAM Airlines
Deal found 6/20$962
This Expedia deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/16:00 am
STL
-
SCL
1 stop22h 40m
LATAM Airlines
Mon 12/1412:55 am
SCL
-
STL
1 stop19h 11m
LATAM Airlines
Deal found 6/16$978
This Expedia deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/283:42 pm
STL
-
SCL
2 stops22h 48m
LATAM Airlines
Wed 11/1112:10 am
SCL
-
STL
1 stop13h 38m
LATAM Airlines
Deal found 6/19$983
This Orbitz deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/141:22 pm
STL
-
SCL
3 stops23h 03m
LATAM Airlines
Tue 7/218:40 pm
SCL
-
STL
1 stop14h 03m
LATAM Airlines
Deal found 6/16$988
This Expedia deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/181:30 pm
STL
-
SCL
3 stops21h 00m
LATAM Airlines
Wed 11/258:45 am
SCL
-
STL
2 stops17h 54m
LATAM Airlines
Deal found 6/17$993
This LATAM Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/45:36 pm
STL
-
SCL
1 stop12h 39m
LATAM Airlines
Sat 7/116:00 pm
SCL
-
STL
3 stops24h 53m
LATAM Airlines
Deal found 6/16$1,027
This United Airlines deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/81:08 pm
STL
-
SCL
2 stops16h 42m
United Airlines
Wed 11/1110:45 pm
SCL
-
STL
1 stop14h 20m
United Airlines
Deal found 6/20$1,161

Find flight deals from St. Louis to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 21, 2026.

Most accurate provider

Ovago
3 stars

Most trusted provider

Ovago
3 stars

Round-trip from

$947
(American Airlines)

One-way from

$479
(Kiwi.com)

Popular in

January

Cheapest in

March

Average price

$1,605
Provider with most accurate pricing for Lambert-St Louis-Santiago Arturo Merino Benitez flight deals.
Provider most trusted by Cheapflights users for Lambert-St Louis-Santiago Arturo Merino Benitez flights.
From Lambert-St Louis to Santiago Arturo Merino Benitez
One-way flight from Lambert-St Louis to Santiago Arturo Merino Benitez
Highest demand for flights based on searches. 11% potential increase in price ($152 potential increase over avg. RT price).
Cheapest flight prices on average. 6% potential price decrease ($70 potential savings vs. average RT price).
Average for round-trip flights in June 2026

Cheapflights Fare Finder

 
Customize your flight search to find flights from St. Louis to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 21, 2026.
Use the filters below to find and compare flights from St. Louis to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 10/28

1:08 pm-7:50 am

2 stops16h 42m

Santiago Arturo Merino Benitez

Wed 11/11

10:45 pm-6:25 pm

1 stop22h 40m

$947
Quickest round-trip

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 9/2

11:35 am-7:05 am

1 stop18h 30m

Santiago Arturo Merino Benitez

Mon 9/7

9:50 pm-10:39 am

1 stop14h 49m

$947

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 11/18

11:00 am-8:50 am

1 stop18h 50m

Santiago Arturo Merino Benitez

Wed 11/25

10:45 pm-4:35 pm

1 stop20h 50m

$947

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Tue 9/1

9:32 am-6:25 am

2 stops19h 53m

Santiago Arturo Merino Benitez

Sun 9/6

9:50 pm-5:01 pm

2 stops21h 11m

$952

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 9/2

6:00 am-10:49 am

3 stops27h 49m

Santiago Arturo Merino Benitez

Mon 9/7

4:30 pm-11:42 pm

2 stops33h 12m

$957
Cheapest one-way

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Fri 7/10

4:09 pm-11:26 pm

2 stops54h 17m

$577
Quickest one-way

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Mon 8/24

12:55 pm-7:05 am

2 stops17h 10m

$633

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Mon 8/24

11:00 am-1:25 pm

3 stops25h 25m

$638

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/16

Sorted by cheapest first

Compare providers for flights from St. Louis to Santiago

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Santiago in June.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
OvagoPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on St. Louis-Santiago flights, users find the pricing of Ovago to be most consistent on Cheapflights vs. Ovago Users can find the same prices on St. Louis-Santiago flight deals on Cheapflights vs. Ovago >95% of the time. Price accuracy is based on data collected from St. Louis-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on St. Louis-Santiago flights, Cheapflights users trust Ovago the most. Ovago has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from St. Louis to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Santiago

What is the cheapest month to book a flight from St. Louis to Santiago?

Currently, March is the cheapest month in which you can book a flight from St. Louis to Santiago (average of $823). Flying from St. Louis to Santiago in January is currently the most expensive (average of $1,948). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from St. Louis to Santiago?

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated June 21, 2026.
Peruse reviews from past customers who have flown with Delta,LATAM Airlines, andAmerican Airlines from St. Louis to Santiago to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Food

7.2

Entertainment

7.8

Overall

7.8

Comfort

7.8

Crew

8.5

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Anonymous,May 2026

SEA - KOA

The snacks were not very good, not everyone was very friendly and professional

Food

7.2

Entertainment

7.8

Overall

7.8

Comfort

7.8

Crew

8.5

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Anonymous,May 2026

SEA - KOA

The snacks were not very good, not everyone was very friendly and professional

Food

7.2

Entertainment

7.8

Overall

7.8

Comfort

7.8

Crew

8.5

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Anonymous,May 2026

SEA - KOA

The snacks were not very good, not everyone was very friendly and professional

Food

7.2

Entertainment

7.8

Overall

7.8

Comfort

7.8

Crew

8.5

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Anonymous,May 2026

SEA - KOA

The snacks were not very good, not everyone was very friendly and professional

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • How long is the flight from St. Louis to Santiago?

    Airlines like United Airlines and American Airlines fly from St. Louis to Santiago in about 16h 42m. The time it takes to get you to your destination can typically vary by up to 1h 48m. The distance between St. Louis and Santiago is about 5137 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from St. Louis to Santiago round-trip?

    Flying on Delta is currently your cheapest option to Santiago, with prices starting at $611. Additional round-trip tickets that might be worth considering are offered by American Airlines and LATAM Airlines, with the lowest prices starting at $689 and $792, respectively. These flights start at 48% lower than the current average price 3 months from now.

  • Can I find deals for flights from St. Louis to Santiago that include hotel bookings?

    Yes. In addition to deals on St. Louis to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Santiago.

  • Can I find deals for business class flights from St. Louis to Santiago?

    Yes. Cheapflights offers flight deals from St. Louis to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from St. Louis to Santiago?

    Currently, March is the cheapest month in which you can book a flight from St. Louis to Santiago (average of $823). Flying from St. Louis to Santiago in January is currently the most expensive (average of $1,948). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for St. Louis to Santiago

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from St. Louis to Santiago

Discover the top 3 airlines that operate flights from St. Louis to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 21, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$574Average$894FlexibilityNo cancel feeOn-time71%
DeltaCheapest$611Average$1,112FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$792Average$908FlexibilityNo cancel feeOn-time81%

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