HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Santiago

$416+ Cheap flights from St. Louis (STL) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/4. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SCL
Mar 6 — Mar 131
Fri 3/6
Fri 3/13
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from St. Louis to Santiago with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from St. Louis to Santiago

Cheapest flights from St. Louis to Santiago
Explore the most affordable flight options available from St. Louis to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 4, 2026.

This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/58:50 am
STL
-
SCL
1 stop21h 00m
United Airlines
Thu 11/2610:45 pm
SCL
-
STL
1 stop20h 50m
United Airlines
Deal found 2/1$825
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/114:47 pm
STL
-
SCL
1 stop13h 03m
United Airlines
Mon 3/239:45 pm
SCL
-
STL
1 stop26h 31m
United Airlines
Deal found 2/2$842
This LATAM Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/310:13 am
STL
-
SCL
1 stop18h 27m
LATAM Airlines
Tue 3/1011:25 pm
SCL
-
STL
2 stops20h 28m
LATAM Airlines
Deal found 2/2$844
This United Airlines deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/910:05 am
STL
-
SCL
1 stop19h 45m
United Airlines
Tue 3/179:45 pm
SCL
-
STL
1 stop20h 20m
United Airlines
Deal found 2/4$858
This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/126:25 am
STL
-
SCL
2 stops23h 25m
United Airlines
Tue 3/249:45 pm
SCL
-
STL
2 stops16h 42m
United Airlines
Deal found 2/1$863
This American Airlines deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/116:20 pm
STL
-
SCL
1 stop12h 45m
American Airlines
Mon 3/239:20 pm
SCL
-
STL
1 stop28h 38m
American Airlines
Deal found 2/4$865
This Delta deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/86:59 pm
STL
-
SCL
1 stop34h 41m
Delta
Thu 3/2610:25 pm
SCL
-
STL
1 stop18h 48m
Delta
Deal found 2/1$866
This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/1210:05 am
STL
-
SCL
1 stop19h 45m
United Airlines
Mon 3/239:45 pm
SCL
-
STL
1 stop26h 31m
United Airlines
Deal found 2/1$867
This KAYAK deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/86:59 pm
STL
-
SCL
1 stop34h 41m
LATAM Airlines
Thu 3/1210:25 pm
SCL
-
STL
1 stop14h 44m
LATAM Airlines
Deal found 2/3$881
This KAYAK deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/141:30 pm
STL
-
SCL
2 stops16h 25m
LATAM Airlines
Fri 8/214:10 am
SCL
-
STL
2 stops20h 27m
LATAM Airlines
Deal found 2/2$890
This Orbitz deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/117:03 am
STL
-
SCL
2 stops20h 32m
LATAM Airlines
Mon 3/238:15 am
SCL
-
STL
3 stops28h 54m
LATAM Airlines
Deal found 2/1$893

Find flight deals from St. Louis to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 4, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$842
(United Airlines)

Popular in

January

Cheapest in

July

Average price

$1,183
Provider with most accurate pricing for Lambert-St Louis-Santiago Arturo Merino Benitez flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-Santiago Arturo Merino Benitez flights.
Search Deals
From Lambert-St Louis to Santiago Arturo Merino Benitez
Search Deals
Highest demand for flights based on searches. 16% potential increase in price ($208 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($56 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from St. Louis to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 4, 2026.
Use the filters below to find and compare flights from St. Louis to Santiago that are best for you.

Fly from

St. Louis

Fly to

Santiago

Route

Depart

Return

Price

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 3/11

4:47 pm-7:50 am

1 stop13h 03m

Santiago Arturo Merino Benitez

Mon 3/23

9:45 pm-10:16 pm

1 stop26h 31m

$842

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Tue 3/3

5:00 pm-2:05 pm

2 stops18h 05m

Santiago Arturo Merino Benitez

Tue 3/10

11:25 pm-5:53 pm

2 stops20h 28m

$844

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Tue 3/10

12:04 pm-7:40 am

1 stop17h 36m

Santiago Arturo Merino Benitez

Mon 3/23

10:40 pm-4:31 pm

1 stop19h 51m

$858

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 3/11

4:47 pm-7:50 am

1 stop13h 03m

Santiago Arturo Merino Benitez

Wed 3/25

9:45 pm-9:21 am

1 stop13h 36m

$858

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Mon 3/9

9:41 am-5:55 am

1 stop18h 14m

Santiago Arturo Merino Benitez

Mon 3/23

10:40 pm-4:31 pm

1 stop19h 51m

$858

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Tue 3/3

4:28 pm-8:50 am

1 stop13h 22m

Santiago Arturo Merino Benitez

Tue 3/10

9:45 pm-9:21 am

1 stop13h 36m

$858

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 3/4

8:17 pm-11:40 pm

3 stops48h 23m

$416

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 3/4

11:46 am-8:05 am

1 stop17h 19m

$417

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/4

Compare providers for flights from St. Louis to Santiago

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Santiago in February.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
OvagoPrice Accuracy2 starsTrust Score*3 stars
AranGrantPrice Accuracy2 starsTrust Score*2 stars
CheapfaremartPrice Accuracy-Trust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on St. Louis-Santiago flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on St. Louis-Santiago flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from St. Louis-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on St. Louis-Santiago flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from St. Louis to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Santiago

What is the cheapest month to book a flight from St. Louis to Santiago?

Currently, March is the cheapest month in which you can book a flight from St. Louis to Santiago (average of $594). Flying from St. Louis to Santiago in June is currently the most expensive (average of $989). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from St. Louis to Santiago?

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated February 4, 2026.
Peruse reviews from past customers who have flown with Delta, LATAM Airlines, and American Airlines from St. Louis to Santiago to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,146 reviews

Boarding

8.1

Comfort

7.9

Crew

8.5

Overall

7.9

Entertainment

7.8

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,146 reviews
Delta
7.9
Good
8,146 reviews

Boarding

8.1

Comfort

7.9

Crew

8.5

Overall

7.9

Entertainment

7.8

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
LATAM Airlines
7.5
Good
1,918 reviews
Delta
7.9
Good
8,146 reviews

Boarding

8.1

Comfort

7.9

Crew

8.5

Overall

7.9

Entertainment

7.8

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,222 reviews
Delta
7.9
Good
8,146 reviews

Boarding

8.1

Comfort

7.9

Crew

8.5

Overall

7.9

Entertainment

7.8

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from St. Louis to Santiago?

    Airlines like United Airlines fly from St. Louis to Santiago in about 13h 03m. The time it takes to get you to your destination can typically vary by up to . The distance between St. Louis and Santiago is about 5137 mi.

  • What are the cheapest airlines flying from St. Louis to Santiago round-trip?

    Flying on American Airlines is currently your cheapest option to Santiago, with prices starting at $689. Additional round-trip tickets that might be worth considering are offered by Delta and LATAM Airlines, with the lowest prices starting at $755 and $801, respectively. These flights start at 33% lower than the current average price 3 months from now.

  • Can I find deals for flights from St. Louis to Santiago that include hotel bookings?

    Yes. In addition to deals on St. Louis to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Santiago.

  • Can I find deals for business class flights from St. Louis to Santiago?

    Yes. Cheapflights offers flight deals from St. Louis to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from St. Louis to Santiago?

    Currently, March is the cheapest month in which you can book a flight from St. Louis to Santiago (average of $594). Flying from St. Louis to Santiago in June is currently the most expensive (average of $989). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for St. Louis to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
Kansas City to Santiago flights
Springfield to Santiago flights
Kansas City to Balmaceda flights
St. Louis to Easter Island flights

Top 3 airlines flying from St. Louis to Santiago

Discover the top 3 airlines that operate flights from St. Louis to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 4, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$689Average$1,074FlexibilityNo cancel feeOn-time71%
DeltaCheapest$755Average$1,013FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$801Average$913FlexibilityNo cancel feeOn-time81%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.