$427+ Cheap flights from St. Louis (STL) to Santiago (SCL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/24. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SCL
mai 11 — mai 181
Round-trip
1 adult, Economy
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Find cheap flights from St. Louis to Santiago with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from St. Louis to Santiago
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Best
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Cheapest flights from St. Louis to SantiagoExplore the most affordable flight options available from St. Louis to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on abril 11, 2026.
Explore the most affordable flight options available from St. Louis to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on abril 11, 2026.
This American Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ter 12/14:21 pm
STL
- SCL
1 stop13h 39m
American Airlines
qui 12/1011:45 pm
SCL
- STL
1 stop15h 47m
American Airlines
Deal found 4/8![American Airlines logo]()
$925
This United Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ter 12/18:15 pm
STL
- SCL
2 stops33h 35m
United Airlines
qui 12/1010:45 pm
SCL
- STL
2 stops18h 33m
United Airlines
Deal found 4/6![United Airlines logo]()
$930
This KAYAK deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ter 12/16:00 am
STL
- SCL
3 stops25h 04m
LATAM Airlines
qui 12/106:45 pm
SCL
- STL
2 stops19h 03m
LATAM Airlines
Deal found 4/6![LATAM Airlines logo]()
$935
This Expedia deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ter 12/14:40 pm
STL
- SCL
1 stop12h 00m
LATAM Airlines
qui 12/1012:10 am
SCL
- STL
1 stop13h 38m
LATAM Airlines
Deal found 4/8![LATAM Airlines logo]()
$956
This Air Canada deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom 10/254:15 pm
STL
- SCL
1 stop16h 00m
Air Canada
sáb 10/317:55 pm
SCL
- STL
1 stop22h 35m
Air Canada
Deal found 4/6![Air Canada logo]()
$965
This American Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ter 5/1211:06 am
STL
- SCL
1 stop18h 59m
American Airlines
ter 6/169:00 pm
SCL
- STL
1 stop14h 35m
American Airlines
Deal found 4/8![American Airlines logo]()
$972
This Air Canada deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
seg 11/94:15 pm
STL
- SCL
1 stop16h 00m
Air Canada
qui 11/127:55 pm
SCL
- STL
1 stop22h 35m
Air Canada
Deal found 4/6![Air Canada logo]()
$975
This American Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
qui 10/110:34 am
STL
- SCL
2 stops20h 16m
American Airlines
sex 10/99:30 pm
SCL
- STL
2 stops17h 25m
American Airlines
Deal found 4/8![American Airlines logo]()
$980
This KAYAK deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
qui 10/11:30 pm
STL
- SCL
1 stop16h 45m
LATAM Airlines
sex 10/98:40 pm
SCL
- STL
1 stop13h 32m
LATAM Airlines
Deal found 4/8![LATAM Airlines logo]()
$985
This Delta deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
seg 5/255:20 pm
STL
- SCL
1 stop12h 55m
Delta
seg 6/17:55 pm
SCL
- STL
2 stops21h 15m
Delta
Deal found 4/10![Delta logo]()
$995
Best flights from St. Louis to SantiagoDiscover carefully curated flight deals from St. Louis to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated abril 11, 2026.
Discover carefully curated flight deals from St. Louis to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated abril 11, 2026.
This American Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ter 5/1211:06 am
STL
- SCL
1 stop18h 59m
American Airlines
ter 6/169:00 pm
SCL
- STL
1 stop14h 35m
American Airlines
Deal found 4/8![American Airlines logo]()
$972
This Delta deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
seg 5/255:20 pm
STL
- SCL
1 stop12h 55m
Delta
seg 6/17:55 pm
SCL
- STL
2 stops21h 15m
Delta
Deal found 4/10![Delta logo]()
$995
This KAYAK deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ter 5/1210:49 am
STL
- SCL
3 stops23h 00m
LATAM Airlines
ter 6/164:10 am
SCL
- STL
2 stops20h 46m
LATAM Airlines
Deal found 4/8![LATAM Airlines logo]()
$1,027
This American Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
qui 10/110:34 am
STL
- SCL
2 stops20h 16m
American Airlines
sex 10/99:30 pm
SCL
- STL
2 stops17h 25m
American Airlines
Deal found 4/8![American Airlines logo]()
$980
This KAYAK deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sex 7/35:07 pm
STL
- SCL
2 stops23h 18m
LATAM Airlines
sáb 7/1111:05 pm
SCL
- STL
2 stops19h 48m
LATAM Airlines
Deal found 4/8![LATAM Airlines logo]()
$1,069
This Delta deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sex 7/310:51 am
STL
- SCL
1 stop19h 24m
Delta
sáb 7/1111:25 pm
SCL
- STL
2 stops20h 34m
Delta
Deal found 4/10![Delta logo]()
$1,090
This American Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sex 7/35:17 am
STL
- SCL
1 stop24h 33m
American Airlines
sáb 7/118:30 pm
SCL
- STL
1 stop14h 54m
American Airlines
Deal found 4/6![American Airlines logo]()
$1,164
This Expedia deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
seg 5/257:01 pm
STL
- SCL
2 stops21h 24m
LATAM Airlines
seg 6/16:00 pm
SCL
- STL
3 stops24h 46m
LATAM Airlines
Deal found 4/10![LATAM Airlines logo]()
$1,231
This KAYAK deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
qua 9/21:30 pm
STL
- SCL
2 stops16h 25m
LATAM Airlines
seg 9/77:45 am
SCL
- STL
2 stops17h 52m
LATAM Airlines
Deal found 4/7![LATAM Airlines logo]()
$1,234
This KAYAK deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
qui 6/253:45 pm
STL
- SCL
1 stop14h 30m
LATAM Airlines
ter 6/308:40 pm
SCL
- STL
1 stop20h 18m
LATAM Airlines
Deal found 4/6![LATAM Airlines logo]()
$1,235
Last-minute flights from St. Louis to SantiagoDiscover last-minute flight deals from St. Louis to Santiago. Data last updated abril 11, 2026 and is based on user searches.
Discover last-minute flight deals from St. Louis to Santiago. Data last updated abril 11, 2026 and is based on user searches.
This BusinessClass deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sex 4/1010:12 am
STL
- SCL
2 stops19h 43m
LATAM Airlines
dom 4/127:45 am
SCL
- STL
2 stops17h 13m
LATAM Airlines
Deal found 4/6![LATAM Airlines logo]()
$6,461
This American Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ter 5/1211:06 am
STL
- SCL
1 stop18h 59m
American Airlines
ter 6/169:00 pm
SCL
- STL
1 stop14h 35m
American Airlines
Deal found 4/8![American Airlines logo]()
$972
This KAYAK deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ter 5/1210:49 am
STL
- SCL
3 stops23h 00m
LATAM Airlines
ter 6/164:10 am
SCL
- STL
2 stops20h 46m
LATAM Airlines
Deal found 4/8![LATAM Airlines logo]()
$1,027
This Mytrip deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ter 5/121:05 pm
STL
- SCL
3 stops33h 15m
Multiple Airlines
ter 6/167:45 am
SCL
- STL
3 stops29h 21m
Multiple Airlines
Deal found 4/8![Multiple Airlines logo]()
$1,263
This Delta deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
seg 5/255:20 pm
STL
- SCL
1 stop12h 55m
Delta
seg 6/17:55 pm
SCL
- STL
2 stops21h 15m
Delta
Deal found 4/10![Delta logo]()
$995
This Expedia deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
seg 5/255:20 pm
STL
- SCL
1 stop12h 55m
LATAM Airlines
seg 6/16:00 pm
SCL
- STL
3 stops24h 46m
LATAM Airlines
Deal found 4/10![LATAM Airlines logo]()
$1,026
This Mytrip deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
seg 5/252:15 pm
STL
- SCL
3 stops35h 20m
Multiple Airlines
seg 6/15:00 am
SCL
- STL
3 stops32h 06m
Multiple Airlines
Deal found 4/10![Multiple Airlines logo]()
$1,200
One-way flights from St. Louis to SantiagoSearch for one-way flight options from St. Louis to Santiago. Find affordable one-way fares based on user searches. Data last updated abril 11, 2026.
Search for one-way flight options from St. Louis to Santiago. Find affordable one-way fares based on user searches. Data last updated abril 11, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
qua 6/245:33 pm
STL
- SCL
3 stops34h 12m
Multiple Airlines
Deal found 4/6![Multiple Airlines logo]()
$427
This KAYAK deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
qua 6/2410:51 am
STL
- SCL
2 stops17h 44m
LATAM Airlines
Deal found 4/7![LATAM Airlines logo]()
$580
This American Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
qua 6/2411:15 am
STL
- SCL
1 stop18h 50m
American Airlines
Deal found 4/6![American Airlines logo]()
$603
Find flight deals from St. Louis to Santiago
Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated abril 11, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $972 (American Airlines) |
One-way from | $427 (Kiwi.com) |
Popular in | January |
Cheapest in | March |
Average price | $935 |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated abril 11, 2026.
Use the filters below to find and compare flights from St. Louis to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
ter 5/12
11:06 am-7:05 am
1 stop18h 59m
Santiago Arturo Merino Benitez
ter 6/16
9:00 pm-10:35 am
1 stop14h 35m
$972
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
qui 10/1
10:34 am-8:50 am
2 stops20h 16m
Santiago Arturo Merino Benitez
sex 10/9
9:30 pm-12:55 pm
2 stops17h 25m
$980
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
seg 5/25
5:20 pm-7:15 am
1 stop12h 55m
Santiago Arturo Merino Benitez
seg 6/1
7:55 pm-4:10 pm
2 stops21h 15m
$995
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
ter 5/12
10:49 am-10:49 am
3 stops23h 00m
Santiago Arturo Merino Benitez
ter 6/16
4:10 am-11:56 pm
2 stops20h 46m
$1,027
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
sex 7/3
5:07 pm-5:25 pm
2 stops23h 18m
Santiago Arturo Merino Benitez
sáb 7/11
11:05 pm-5:53 pm
2 stops19h 48m
$1,069
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
sex 7/3
10:51 am-7:15 am
1 stop19h 24m
Santiago Arturo Merino Benitez
sáb 7/11
11:25 pm-6:59 pm
2 stops20h 34m
$1,090
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
sex 7/3
5:17 am-6:50 am
1 stop24h 33m
Santiago Arturo Merino Benitez
sáb 7/11
8:30 pm-10:24 am
1 stop14h 54m
$1,164
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
seg 5/25
7:01 pm-5:25 pm
2 stops21h 24m
Santiago Arturo Merino Benitez
seg 6/1
6:00 pm-5:46 pm
3 stops24h 46m
$1,231
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
qua 9/2
1:30 pm-6:55 am
2 stops16h 25m
Santiago Arturo Merino Benitez
seg 9/7
7:45 am-11:37 pm
2 stops17h 52m
$1,234
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
qui 6/25
3:45 pm-7:15 am
1 stop14h 30m
Santiago Arturo Merino Benitez
ter 6/30
8:40 pm-3:58 pm
1 stop20h 18m
$1,235
Showing 1-10 of 13 resultsSorted by cheapest first
Compare providers for flights from St. Louis to Santiago
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Santiago in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*2 stars |
- Most accurate provider: When it comes to deals on St. Louis-Santiago flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on St. Louis-Santiago flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from St. Louis-Santiago flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on St. Louis-Santiago flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from St. Louis to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from St. Louis with our price prediction graph.
STL-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to Santiago
What is the cheapest month to book a flight from St. Louis to Santiago?
Currently, March is the cheapest month in which you can book a flight from St. Louis to Santiago (average of $538). Flying from St. Louis to Santiago in June is currently the most expensive (average of $1,115). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from St. Louis to Santiago?
Reviews of airlines servicing Santiago
Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated abril 11, 2026.
Peruse reviews from past customers who have flown with Delta,LATAM Airlines, andAmerican Airlines from St. Louis to Santiago to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.9
Crew
8.5
Boarding
8.1
Entertainment
7.8
Food
7.2
Comfort
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Overall
7.9
Crew
8.5
Boarding
8.1
Entertainment
7.8
Food
7.2
Comfort
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Overall
7.9
Crew
8.5
Boarding
8.1
Entertainment
7.8
Food
7.2
Comfort
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Overall
7.9
Crew
8.5
Boarding
8.1
Entertainment
7.8
Food
7.2
Comfort
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Related info for your journey
Find useful and relevant information for your journey from St. Louis to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Other flights from St. Louis
Popular flights
Santiago flight routes
Alternative routes for St. Louis to Santiago
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from St. Louis to Santiago by cabin class
Find flights from St. Louis to Santiago, based on your preferred cabin class, be it economy, premium economy, business, or first class.
St. Louis and Santiago flights
Browse other St. Louis and Santiago flight options. Last updated on abril 11, 2026.
Other flights from St. Louis
Browse through other flights departing from St. Louis. Flights are based on user searches made on Cheapflights and were last updated on abril 11, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on abril 11, 2026.
Top 3 airlines flying from St. Louis to Santiago
Discover the top 3 airlines that operate flights from St. Louis to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated abril 11, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$611 | Average$1,083 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$689 | Average$1,053 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$803 | Average$908 | FlexibilityNo cancel fee | On-time81% |