$353+ Cheap flights from St. Louis (STL) to Santiago (SCL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/14. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SCL
Jul 7 — Jul 141
Round-trip
1 adult, Economy
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Find cheap flights from St. Louis to Santiago with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Best
Last-minute
One-way
Cheapest flights from St. Louis to SantiagoExplore the most affordable flight options available from St. Louis to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 7, 2026.
Explore the most affordable flight options available from St. Louis to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 7, 2026.
This American Airlines deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/511:35 am
STL
- SCL
1 stop18h 30m
American Airlines
Wed 8/128:50 pm
SCL
- STL
1 stop14h 55m
American Airlines
Deal found 6/6![American Airlines logo]()
$957
This Travelocity deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/231:30 pm
STL
- SCL
2 stops28h 15m
LATAM Airlines
Wed 12/301:40 am
SCL
- STL
2 stops19h 21m
LATAM Airlines
Deal found 6/7![LATAM Airlines logo]()
$993
This American Airlines deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/95:10 pm
STL
- SCL
1 stop13h 40m
American Airlines
Fri 9/189:30 pm
SCL
- STL
1 stop20h 45m
American Airlines
Deal found 6/6![American Airlines logo]()
$997
This KAYAK deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/91:30 pm
STL
- SCL
3 stops21h 55m
LATAM Airlines
Fri 9/187:50 am
SCL
- STL
2 stops17h 46m
LATAM Airlines
Deal found 6/6![LATAM Airlines logo]()
$1,022
This Orbitz deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/910:55 am
STL
- SCL
1 stop19h 20m
LATAM Airlines
Fri 9/1812:00 am
SCL
- STL
2 stops25h 36m
LATAM Airlines
Deal found 6/6![LATAM Airlines logo]()
$1,038
This American Airlines deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/1311:00 am
STL
- SCL
1 stop19h 00m
American Airlines
Thu 8/208:50 pm
SCL
- STL
1 stop14h 55m
American Airlines
Deal found 6/2![American Airlines logo]()
$1,051
This Ovago deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/15:30 pm
STL
- SCL
2 stops28h 52m
Copa Airlines
Sun 9/65:14 am
SCL
- STL
2 stops32h 48m
Copa Airlines
Deal found 6/3![Copa Airlines logo]()
$1,057
Best flights from St. Louis to SantiagoDiscover carefully curated flight deals from St. Louis to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 7, 2026.
Discover carefully curated flight deals from St. Louis to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 7, 2026.
This American Airlines deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/53:25 pm
STL
- SCL
2 stops14h 40m
American Airlines
Wed 8/128:50 pm
SCL
- STL
2 stops17h 12m
American Airlines
Deal found 6/6![American Airlines logo]()
$981
This Ovago deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/15:30 pm
STL
- SCL
2 stops34h 40m
Copa Airlines
Sat 9/51:43 am
SCL
- STL
2 stops22h 17m
Copa Airlines
Deal found 6/5![Copa Airlines logo]()
$1,113
This Delta deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/139:24 am
STL
- SCL
1 stop20h 51m
Delta
Wed 7/2211:05 pm
SCL
- STL
2 stops19h 48m
Delta
Deal found 6/3![Delta logo]()
$1,155
This Expedia deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/512:52 pm
STL
- SCL
2 stops27h 33m
LATAM Airlines
Wed 8/128:30 am
SCL
- STL
3 stops28h 16m
LATAM Airlines
Deal found 6/6![LATAM Airlines logo]()
$1,172
This Delta deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/1510:51 am
STL
- SCL
2 stops16h 49m
Delta
Wed 7/228:40 pm
SCL
- STL
1 stop22h 13m
Delta
Deal found 6/3![Delta logo]()
$1,155
This eDestinos deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/31:39 pm
STL
- SCL
2 stops14h 56m
LATAM Airlines
Fri 7/107:25 am
SCL
- STL
2 stops17h 28m
LATAM Airlines
Deal found 6/4![LATAM Airlines logo]()
$1,229
This Delta deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/1410:51 am
STL
- SCL
2 stops18h 09m
Delta
Wed 7/2211:05 pm
SCL
- STL
2 stops19h 48m
Delta
Deal found 6/3![Delta logo]()
$1,155
This American Airlines deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/211:35 am
STL
- SCL
1 stop18h 30m
American Airlines
Mon 9/79:50 pm
SCL
- STL
1 stop14h 49m
American Airlines
Deal found 6/7![American Airlines logo]()
$1,295
This Delta deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/136:58 pm
STL
- SCL
2 stops18h 07m
Delta
Tue 7/214:10 am
SCL
- STL
2 stops20h 43m
Delta
Deal found 6/3![Delta logo]()
$1,155
This Delta deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/181:15 pm
STL
- SCL
1 stop17h 00m
Delta
Sat 7/258:40 pm
SCL
- STL
1 stop19h 08m
Delta
Deal found 6/3![Delta logo]()
$1,235
Last-minute flights from St. Louis to SantiagoDiscover last-minute flight deals from St. Louis to Santiago. Data last updated June 7, 2026 and is based on user searches.
Discover last-minute flight deals from St. Louis to Santiago. Data last updated June 7, 2026 and is based on user searches.
This Mytrip deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/102:15 pm
STL
- SCL
3 stops35h 20m
Multiple Airlines
Mon 6/154:10 am
SCL
- STL
3 stops32h 56m
Multiple Airlines
Deal found 6/3![Multiple Airlines logo]()
$1,176
This eDestinos deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/36:00 am
STL
- SCL
2 stops22h 35m
LATAM Airlines
Fri 7/108:40 pm
SCL
- STL
1 stop16h 50m
LATAM Airlines
Deal found 6/4![LATAM Airlines logo]()
$1,188
This American Airlines deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/1311:00 am
STL
- SCL
1 stop19h 00m
American Airlines
Thu 8/208:50 pm
SCL
- STL
1 stop14h 55m
American Airlines
Deal found 6/2![American Airlines logo]()
$1,051
This Delta deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/139:24 am
STL
- SCL
1 stop20h 51m
Delta
Wed 7/2211:05 pm
SCL
- STL
2 stops19h 48m
Delta
Deal found 6/3![Delta logo]()
$1,155
This KAYAK deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/133:58 pm
STL
- SCL
3 stops20h 27m
LATAM Airlines
Thu 8/204:10 am
SCL
- STL
2 stops20h 48m
LATAM Airlines
Deal found 6/2![LATAM Airlines logo]()
$1,160
This American Airlines deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/1411:00 am
STL
- SCL
1 stop19h 00m
American Airlines
Tue 7/219:00 pm
SCL
- STL
1 stop14h 24m
American Airlines
Deal found 6/3![American Airlines logo]()
$1,145
This KAYAK deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/1410:51 am
STL
- SCL
3 stops22h 58m
LATAM Airlines
Tue 7/214:10 am
SCL
- STL
2 stops20h 43m
LATAM Airlines
Deal found 6/3![LATAM Airlines logo]()
$1,165
This KAYAK deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/206:00 am
STL
- SCL
2 stops22h 14m
Copa Airlines
Thu 7/3011:22 am
SCL
- STL
2 stops29h 24m
Copa Airlines
Deal found 6/3![Copa Airlines logo]()
$1,156
This Kiwi.com deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/255:42 pm
STL
- SCL
1 stop12h 33m
Multiple Airlines
Fri 7/318:40 am
SCL
- STL
3 stops31h 16m
Multiple Airlines
Deal found 6/3![Multiple Airlines logo]()
$1,209
One-way flights from St. Louis to SantiagoSearch for one-way flight options from St. Louis to Santiago. Find affordable one-way fares based on user searches. Data last updated June 7, 2026.
Search for one-way flight options from St. Louis to Santiago. Find affordable one-way fares based on user searches. Data last updated June 7, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/144:57 pm
STL
- SCL
3 stops33h 03m
Multiple Airlines
Deal found 6/6![Multiple Airlines logo]()
$353
This Kiwi.com deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/136:34 pm
STL
- SCL
3 stops30h 46m
Multiple Airlines
Deal found 6/6![Multiple Airlines logo]()
$357
This Kiwi.com deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/124:09 pm
STL
- SCL
2 stops26h 27m
Multiple Airlines
Deal found 6/6![Multiple Airlines logo]()
$391
This American Airlines deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1211:35 am
STL
- SCL
1 stop18h 30m
American Airlines
Deal found 6/6![American Airlines logo]()
$624
This American Airlines deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/2411:35 am
STL
- SCL
1 stop18h 30m
American Airlines
Deal found 6/4![American Airlines logo]()
$628
This KAYAK deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/2412:52 pm
STL
- SCL
3 stops23h 33m
LATAM Airlines
Deal found 6/4![LATAM Airlines logo]()
$633
This American Airlines deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/1411:35 am
STL
- SCL
1 stop18h 30m
American Airlines
Deal found 6/6![American Airlines logo]()
$673
Find flight deals from St. Louis to Santiago
Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 7, 2026.
Most accurate provider | Ovago 3 stars |
|---|---|
Most trusted provider | Ovago 3 stars |
Round-trip from | $957 (American Airlines) |
One-way from | $348 (Kiwi.com) |
Popular in | January |
Cheapest in | March |
Average price | $1,489 |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 7, 2026.
Use the filters below to find and compare flights from St. Louis to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Wed 8/5
3:25 pm-7:05 am
2 stops14h 40m
Santiago Arturo Merino Benitez
Wed 8/12
8:50 pm-1:02 pm
2 stops17h 12m
$981
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Tue 9/1
5:30 pm-5:10 am
2 stops34h 40m
Santiago Arturo Merino Benitez
Sat 9/5
1:43 am-10:00 pm
2 stops22h 17m
$1,113
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Mon 7/13
9:24 am-7:15 am
1 stop20h 51m
Santiago Arturo Merino Benitez
Wed 7/22
11:05 pm-5:53 pm
2 stops19h 48m
$1,155
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Wed 7/15
10:51 am-4:40 am
2 stops16h 49m
Santiago Arturo Merino Benitez
Wed 7/22
8:40 pm-5:53 pm
1 stop22h 13m
$1,155
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Tue 7/14
10:51 am-6:00 am
2 stops18h 09m
Santiago Arturo Merino Benitez
Wed 7/22
11:05 pm-5:53 pm
2 stops19h 48m
$1,155
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Mon 7/13
6:58 pm-2:05 pm
2 stops18h 07m
Santiago Arturo Merino Benitez
Tue 7/21
4:10 am-11:53 pm
2 stops20h 43m
$1,155
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Wed 8/5
12:52 pm-5:25 pm
2 stops27h 33m
Santiago Arturo Merino Benitez
Wed 8/12
8:30 am-11:46 am
3 stops28h 16m
$1,172
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Fri 7/3
1:39 pm-5:35 am
2 stops14h 56m
Santiago Arturo Merino Benitez
Fri 7/10
7:25 am-11:53 pm
2 stops17h 28m
$1,229
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Sat 7/18
1:15 pm-7:15 am
1 stop17h 00m
Santiago Arturo Merino Benitez
Sat 7/25
8:40 pm-2:48 pm
1 stop19h 08m
$1,235
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Wed 9/2
11:35 am-7:05 am
1 stop18h 30m
Santiago Arturo Merino Benitez
Mon 9/7
9:50 pm-10:39 am
1 stop14h 49m
$1,295
Showing 1-10 of 14 resultsSorted by cheapest first
Compare providers for flights from St. Louis to Santiago
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Santiago in June.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on St. Louis-Santiago flights, users find the pricing of Ovago to be most consistent on Cheapflights vs. Ovago Users can find the same prices on St. Louis-Santiago flight deals on Cheapflights vs. Ovago >95% of the time. Price accuracy is based on data collected from St. Louis-Santiago flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on St. Louis-Santiago flights, Cheapflights users trust Ovago the most. Ovago has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from St. Louis to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from St. Louis with our price prediction graph.
STL-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to Santiago
What is the cheapest month to book a flight from St. Louis to Santiago?
Currently, March is the cheapest month in which you can book a flight from St. Louis to Santiago (average of $793). Flying from St. Louis to Santiago in January is currently the most expensive (average of $1,852). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from St. Louis to Santiago?
Reviews of airlines servicing Santiago
Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated June 7, 2026.
Peruse reviews from past customers who have flown with Delta,LATAM Airlines, andAmerican Airlines from St. Louis to Santiago to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.8
Entertainment
7.8
Food
7.2
Boarding
8.1
Crew
8.5
Overall
7.9
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Comfort
7.8
Entertainment
7.8
Food
7.2
Boarding
8.1
Crew
8.5
Overall
7.9
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Comfort
7.8
Entertainment
7.8
Food
7.2
Boarding
8.1
Crew
8.5
Overall
7.9
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Comfort
7.8
Entertainment
7.8
Food
7.2
Boarding
8.1
Crew
8.5
Overall
7.9
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from St. Louis to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from St. Louis to Santiago by cabin class
Find flights from St. Louis to Santiago, based on your preferred cabin class, be it economy, premium economy, business, or first class.
St. Louis and Santiago flights
Browse other St. Louis and Santiago flight options. Last updated on June 7, 2026.
Other flights from St. Louis
Browse through other flights departing from St. Louis. Flights are based on user searches made on Cheapflights and were last updated on June 7, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on June 7, 2026.
Top 3 airlines flying from St. Louis to Santiago
Discover the top 3 airlines that operate flights from St. Louis to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 7, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$574 | Average$894 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$611 | Average$1,112 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$792 | Average$908 | FlexibilityNo cancel fee | On-time81% |