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$342+ Cheap flights from St. Louis (STL) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/14. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SCL
Oct 16 — Oct 231
Thu 10/16
Thu 10/23
1 adult, Economy
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Cheapflights Tip: The best prices from Lambert-St Louis to Santiago Arturo Merino Benitez are usually found in October or September, booked 1 days in advance, depart on a Wednesday or Monday and return on a Tuesday

Cheap flight deals from St. Louis to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 16, 2025.

Round-trip from

$764
(Delta)

One-way from

$342
(Trip.com)

Popular in

December

Cheapest in

October

Average price

$843
From Lambert-St Louis to Santiago Arturo Merino Benitez
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One-way flight from Lambert-St Louis to Santiago Arturo Merino Benitez
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Highest demand for flights based on searches. 8% potential increase in price ($85 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($21 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from St. Louis to Santiago

Cheapest flights from St. Louis to Santiago
Explore the most affordable flight options available from St. Louis to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2711:04 amSTL - SCL
1 stop17h 36mDelta
Mon 12/88:20 amSCL - STL
2 stops18h 21mDelta
Deal found 9/15$764
This LATAM Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/119:30 amSTL - SCL
2 stops17h 05mLATAM Airlines
Mon 12/1510:35 amSCL - STL
2 stops16h 06mLATAM Airlines
Deal found 9/13$768
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/25:28 amSTL - SCL
1 stop24h 27mAmerican Airlines
Wed 10/89:55 pmSCL - STL
1 stop21h 33mAmerican Airlines
Deal found 9/13$774
This LATAM Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/255:17 pmSTL - SCL
2 stops25h 38mLATAM Airlines
Sun 1/116:30 pmSCL - STL
2 stops26h 34mLATAM Airlines
Deal found 9/16$804
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/43:55 pmSTL - SCL
2 stops20h 30mDelta
Sat 10/115:55 pmSCL - STL
2 stops20h 40mDelta
Deal found 9/16$844
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/17:05 amSTL - SCL
2 stops20h 55mDelta
Sat 11/2211:25 pmSCL - STL
2 stops20h 44mDelta
Deal found 9/15$848
This Expedia deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/235:17 pmSTL - SCL
2 stops33h 18mLATAM Airlines
Tue 12/3012:25 amSCL - STL
2 stops26h 14mLATAM Airlines
Deal found 9/15$861
This Mytrip deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/294:05 pmSTL - SCL
3 stops35h 55mMultiple Airlines
Thu 10/25:55 amSCL - STL
3 stops35h 23mMultiple Airlines
Deal found 9/15$884
This LATAM Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2711:04 amSTL - SCL
2 stops16h 31mLATAM Airlines
Sun 12/712:25 amSCL - STL
2 stops20h 32mLATAM Airlines
Deal found 9/14$894

Cheapflights Fare Finder

 
Customize your flight search to find flights from St. Louis to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
Use the filters below to find and compare flights from St. Louis to Santiago that are best for you.

Fly from

St. Louis

Fly to

Santiago

Route

Depart

Return

Price

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Thu 11/27

11:04 am-6:35 am

2 stops16h 31m

Santiago Arturo Merino Benitez

Mon 12/8

9:30 pm-1:00 pm

1 stop18h 30m

$764

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Thu 12/11

5:12 pm-2:05 pm

2 stops17h 53m

Santiago Arturo Merino Benitez

Mon 12/15

9:30 pm-8:25 am

1 stop13h 55m

$764

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Thu 11/27

7:05 am-7:40 am

1 stop21h 35m

Santiago Arturo Merino Benitez

Mon 12/8

11:10 pm-6:34 pm

1 stop22h 24m

$764

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Thu 10/2

11:04 am-5:45 am

2 stops16h 41m

Santiago Arturo Merino Benitez

Wed 10/8

5:55 pm-10:26 am

2 stops18h 31m

$764

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Thu 10/2

5:28 am-7:55 am

1 stop24h 27m

Santiago Arturo Merino Benitez

Wed 10/8

9:55 pm-5:28 pm

1 stop21h 33m

$774

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Tue 10/14

10:22 am-2:45 pm

2 stops26h 23m

$342

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Mon 1/12

7:43 pm-10:15 pm

3 stops23h 32m

$366

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Mon 10/13

9:59 pm-8:20 pm

3 stops44h 21m

$382

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Mon 1/12

5:02 pm-9:05 am

1 stop13h 03m

$543

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Tue 10/14

9:10 am-7:00 am

1 stop19h 50m

$543

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Showing 1-10 of 12 results
1
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Best time to book a flight from St. Louis to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Santiago

How far ahead should I book a flight from St. Louis to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from St. Louis to Santiago. Price data was last updated on September 12, 2025.

To ensure you get the cheapest price possible for a flight from St. Louis to Santiago, you should look to book at least 1 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from St. Louis to Santiago?

Currently, April is the cheapest month in which you can book a flight from St. Louis to Santiago (average of $752). Flying from St. Louis to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from STL to SCL?

Find hourly flight availability from St. Louis to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 16, 2025.

A simple way to save on the total cost of your ticket is to fly from St. Louis to Santiago at noon. If you’re flexible enough to do this you can expect to save up to 9% on your trip compared to booking a flight in the morning.

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated September 16, 2025.
Peruse reviews from past customers who have flown with Delta, LATAM Airlines, and United Airlines from St. Louis to Santiago to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,957 reviews

Overall

8.0

Boarding

8.2

Food

7.3

Crew

8.5

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,957 reviews
Delta
8.0
Very good
7,957 reviews

Overall

8.0

Boarding

8.2

Food

7.3

Crew

8.5

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
LATAM Airlines
7.5
Good
1,847 reviews
Delta
8.0
Very good
7,957 reviews

Overall

8.0

Boarding

8.2

Food

7.3

Crew

8.5

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,924 reviews
Delta
8.0
Very good
7,957 reviews

Overall

8.0

Boarding

8.2

Food

7.3

Crew

8.5

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,957 reviews

Overall

8.0

Boarding

8.2

Food

7.3

Crew

8.5

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from St. Louis to Santiago?

    Airlines like Delta and LATAM Airlines fly from St. Louis to Santiago in about 16h 31m. The time it takes to get you to your destination can typically vary by up to 1h 22m. The distance between St. Louis and Santiago is about 5137 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from St. Louis to Santiago round-trip?

    Flying on LATAM Airlines is currently your cheapest option to Santiago, with prices starting at $762. Additional round-trip tickets that might be worth considering are offered by Delta and American Airlines, with the lowest prices starting at $803 and $823, respectively. These flights start at 21% lower than the current average price 3 months from now.

  • Can I find deals for flights from St. Louis to Santiago that include hotel bookings?

    Yes. In addition to deals on St. Louis to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Santiago.

  • Can I find deals for business class flights from St. Louis to Santiago?

    Yes. Cheapflights offers flight deals from St. Louis to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from St. Louis to Santiago?

    Currently, April is the cheapest month in which you can book a flight from St. Louis to Santiago (average of $752). Flying from St. Louis to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for St. Louis to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from St. Louis to Santiago

Discover the top 4 airlines that operate flights from St. Louis to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
LATAM AirlinesCheapest$762Average$911FlexibilityNo cancel feeOn-time81%
DeltaCheapest$803Average$1,007FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$823Average$992FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$883Average$1,047FlexibilityNo cancel feeOn-time69%

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