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$64+ Cheap flights from Mendoza (MDZ) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/4. Fares are subject to change and may not be available on all flights or dates of travel.
MDZ — SCL
Feb 25 — Mar 41
Wed 2/25
Wed 3/4
1 adult, Economy
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Cheapflights Tip: The best prices from Mendoza El Plumerillo to Santiago Arturo Merino Benitez are usually found in May or March, booked 88 days in advance, depart on a Saturday or Friday and return on a Friday

Cheap flight deals from Mendoza to Santiago

Cheapest flights from Mendoza to Santiago
Explore the most affordable flight options available from Mendoza to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 26, 2026.

This Mytrip deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/279:00 pm
MDZ
-
SCL
Nonstop1h 05m
Sky Airline
Wed 3/117:05 pm
SCL
-
MDZ
Nonstop1h 05m
Sky Airline
Deal found 1/25$98
This FlightHub deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/39:00 pm
MDZ
-
SCL
Nonstop1h 05m
Sky Airline
Thu 3/121:45 pm
SCL
-
MDZ
Nonstop1h 05m
Sky Airline
Deal found 1/25$109
This Booking.com deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/299:00 pm
MDZ
-
SCL
Nonstop1h 05m
Sky Airline
Thu 2/57:05 pm
SCL
-
MDZ
Nonstop1h 05m
Sky Airline
Deal found 1/25$118
This Trip.com deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/219:00 pm
MDZ
-
SCL
Nonstop1h 05m
Multiple Airlines
Sun 4/267:24 pm
SCL
-
MDZ
Nonstop1h 06m
Multiple Airlines
Deal found 1/26$119
This JetSMART deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetSMART is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/36:30 pm
MDZ
-
SCL
Nonstop0h 56m
JetSMART
Sat 6/137:24 pm
SCL
-
MDZ
Nonstop1h 06m
JetSMART
Deal found 1/24$121
This JetSMART deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetSMART is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/210:20 pm
MDZ
-
SCL
Nonstop1h 04m
JetSMART
Wed 5/272:09 pm
SCL
-
MDZ
Nonstop1h 06m
JetSMART
Deal found 1/25$122
This Sky Airline deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Sky Airline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/53:40 pm
MDZ
-
SCL
Nonstop1h 05m
Sky Airline
Sun 2/81:45 pm
SCL
-
MDZ
Nonstop1h 05m
Sky Airline
Deal found 1/24$130
This CheapOair deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/165:05 pm
MDZ
-
SCL
Nonstop1h 04m
Multiple Airlines
Thu 7/94:58 pm
SCL
-
MDZ
Nonstop1h 05m
Multiple Airlines
Deal found 1/26$131
This JetSMART deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetSMART is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/226:30 pm
MDZ
-
SCL
Nonstop1h 00m
JetSMART
Sat 3/219:20 pm
SCL
-
MDZ
Nonstop1h 05m
JetSMART
Deal found 1/26$132
This Mytrip deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/239:00 pm
MDZ
-
SCL
Nonstop1h 05m
Sky Airline
Mon 3/21:45 pm
SCL
-
MDZ
Nonstop1h 05m
Sky Airline
Deal found 1/26$133
This Trip.com deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/69:15 pm
MDZ
-
SCL
Nonstop1h 05m
Sky Airline
Sat 8/16:10 pm
SCL
-
MDZ
Nonstop1h 05m
Sky Airline
Deal found 1/24$134

Find flight deals from Mendoza to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Mendoza (MDZ) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 26, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$98
(Trip.com)

One-way from

$64
(Trip.com)

Popular in

January

Cheapest in

May

Average price

$151

Good round-trip deal

$146 or less

Good one-way deal

$87 or less
Provider with most accurate pricing for Mendoza El Plumerillo-Santiago Arturo Merino Benitez flight deals.
Search Deals
Provider most trusted by Cheapflights users for Mendoza El Plumerillo-Santiago Arturo Merino Benitez flights.
Search Deals
From Mendoza El Plumerillo to Santiago Arturo Merino Benitez
Search Deals
One-way flight from Mendoza El Plumerillo to Santiago Arturo Merino Benitez
Search Deals
Highest demand for flights based on searches. 2% potential increase in price ($4 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 0% potential price decrease ($2 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals
Price to beat on a round-trip flight from Mendoza El Plumerillo to Santiago Arturo Merino Benitez.
Search Deals
Price to beat on a one-way flight from Mendoza El Plumerillo to Santiago Arturo Merino Benitez.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mendoza to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 26, 2026.
Use the filters below to find and compare flights from Mendoza to Santiago that are best for you.

Fly from

Mendoza

Fly to

Santiago

Route

Depart

Return

Price

MendozaSantiago

MDZ - SCL

MDZSCL

Mendoza El Plumerillo

Fri 4/3

6:30 pm-7:26 pm

Nonstop0h 56m

Santiago Arturo Merino Benitez

Sat 6/13

7:24 pm-9:30 pm

Nonstop1h 06m

$121

MendozaSantiago

MDZ - SCL

MDZSCL

Mendoza El Plumerillo

Thu 5/28

5:05 pm-5:09 pm

Nonstop1h 04m

Santiago Arturo Merino Benitez

Sun 6/7

7:24 pm-9:30 pm

Nonstop1h 06m

$122

MendozaSantiago

MDZ - SCL

MDZSCL

Mendoza El Plumerillo

Sat 5/2

10:20 pm-10:24 pm

Nonstop1h 04m

Santiago Arturo Merino Benitez

Wed 5/27

2:09 pm-4:15 pm

Nonstop1h 06m

$122

MendozaSantiago

MDZ - SCL

MDZSCL

Mendoza El Plumerillo

Sat 2/14

9:00 pm-10:05 pm

Nonstop1h 05m

Santiago Arturo Merino Benitez

Sat 2/21

7:05 pm-8:10 pm

Nonstop1h 05m

$130

MendozaSantiago

MDZ - SCL

MDZSCL

Mendoza El Plumerillo

Thu 2/5

3:40 pm-4:45 pm

Nonstop1h 05m

Santiago Arturo Merino Benitez

Sun 2/8

1:45 pm-2:50 pm

Nonstop1h 05m

$130

MendozaSantiago

MDZ - SCL

MDZSCL

Mendoza El Plumerillo

Tue 3/3

3:40 pm-4:45 pm

Nonstop1h 05m

Santiago Arturo Merino Benitez

Sun 3/15

1:45 pm-2:50 pm

Nonstop1h 05m

$130

MendozaSantiago

MDZ - SCL

MDZSCL

Mendoza El Plumerillo

Wed 2/18

6:20 pm-7:25 pm

Nonstop1h 05m

Santiago Arturo Merino Benitez

Mon 4/13

12:45 pm-2:50 pm

Nonstop1h 05m

$130

MendozaSantiago

MDZ - SCL

MDZSCL

Mendoza El Plumerillo

Tue 6/16

5:05 pm-5:09 pm

Nonstop1h 04m

Santiago Arturo Merino Benitez

Wed 7/8

9:00 am-11:06 am

Nonstop1h 06m

$131

MendozaSantiago

MDZ - SCL

MDZSCL

Mendoza El Plumerillo

Mon 2/23

9:00 pm-10:05 pm

Nonstop1h 05m

Santiago Arturo Merino Benitez

Mon 3/2

1:45 pm-2:50 pm

Nonstop1h 05m

$133

MendozaSantiago

MDZ - SCL

MDZSCL

Mendoza El Plumerillo

Sun 3/1

6:30 pm-7:26 pm

Nonstop0h 56m

Santiago Arturo Merino Benitez

Sun 3/8

6:56 am-8:00 am

Nonstop1h 04m

$136

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/25

Showing 1-10 of 21 results
1
2
3
  • Most accurate provider: When it comes to deals on Mendoza-Santiago flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Mendoza-Santiago flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Mendoza-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Mendoza-Santiago flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Mendoza-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Mendoza to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Mendoza with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mendoza to Santiago

How far ahead should I book a flight from Mendoza to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from Mendoza to Santiago. Price data was last updated on January 23, 2026.

The best time to book flights from Mendoza to Santiago is 88 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Mendoza to Santiago?

Currently, June is the cheapest month in which you can book a flight from Mendoza to Santiago (average of $41). Flying from Mendoza to Santiago in September is currently the most expensive (average of $76). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MDZ to SCL?

Find hourly flight availability from Mendoza to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 26, 2026.

One of the essential ways to save on airfare from Mendoza to Santiago is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the afternoon could potentially save you up to 84% on airfare.

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated January 26, 2026.
Peruse reviews from past customers who have flown with LATAM Airlines and JetSMART from Mendoza to Santiago to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
LATAM Airlines
7.5
Good
1,912 reviews

Comfort

7.3

Food

6.7

Boarding

7.6

Crew

8.0

Overall

7.5

Entertainment

7.0

Reviews

1 / 20
2.0
Mediocre

JC,Jan 2026

FLN - GRU

Plane was late in FLN and missed connection in GRU. No alternative was given to me until 6 hours later and I was delayed by over 12 hours total.
LATAM Airlines
7.5
Good
1,912 reviews
LATAM Airlines
7.5
Good
1,912 reviews

Comfort

7.3

Food

6.7

Boarding

7.6

Crew

8.0

Overall

7.5

Entertainment

7.0

Reviews

1 / 20
2.0
Mediocre

JC,Jan 2026

FLN - GRU

Plane was late in FLN and missed connection in GRU. No alternative was given to me until 6 hours later and I was delayed by over 12 hours total.
JetSMART
6.7
Okay
261 reviews
LATAM Airlines
7.5
Good
1,912 reviews

Comfort

7.3

Food

6.7

Boarding

7.6

Crew

8.0

Overall

7.5

Entertainment

7.0

Reviews

1 / 20
2.0
Mediocre

JC,Jan 2026

FLN - GRU

Plane was late in FLN and missed connection in GRU. No alternative was given to me until 6 hours later and I was delayed by over 12 hours total.

Related info for your journey

Find useful and relevant information for your journey from Mendoza to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Mendoza to Santiago?

    If you wish to fly to Santiago from Mendoza, then you need to book flights from Mendoza El Plumerillo to Santiago Arturo Merino Benitez. There are 4 flights from El Plumerillo (MDZ) to Arturo Merino Benitez (SCL) per day to choose from. Flights to Santiago from El Plumerillo are available from 3 different airlines, which means you should have some options if you want to compare airfare deals. 1h 05m is how long a nonstop flight from Mendoza to Santiago Arturo Merino Benitez typically takes.

  • How popular is this Mendoza to Santiago flight route?

    This flight path from Mendoza El Plumerillo to Santiago Arturo Merino Benitez was viewed by 2 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Mendoza to Santiago?

    There are many flights that can get you from Mendoza to Santiago in 1h 05m. Fly via Sky Airline to get the fastest option. The distance between Mendoza and Santiago is about 122 mi. Most flights are nonstop.

  • What are the cheapest airlines flying from Mendoza to Santiago round-trip?

    Cheapflights users have booked flights from Mendoza to Santiago round-trip from $33. Other airlines that can offer you cheap pricing are Sky Airline, from $80, and LATAM Airlines, from $82. Users have found that JetSMART is 76% cheaper than the other options available to this destination.

  • What are the cheapest airlines to fly from Mendoza to Santiago one-way?

    To fly one-way, consider booking your trip with JetSMART, which is currently one of the cheapest options available, starting at $54. Sky Airline flights start at $62 while deals on Aerolineas Argentinas start at $68 one-way.

  • What are the most reliable airlines from Mendoza to Santiago?

    Consider Sky Airline (96%), Iberia (92%) or LATAM Airlines (90%) when booking your flight. These represent the most reliable airlines when flying from Mendoza to Santiago.

  • What are the cheapest flights from Mendoza to Santiago?

    On average you can expect to pay $204 for a flight from Mendoza to Santiago. The cheapest flight overall is $69 while the most popular route, (Mendoza El Plumerillo - Santiago Arturo Merino Benitez) is currently priced at $96.

  • Can I find deals for flights from Mendoza to Santiago that include hotel bookings?

    Yes. In addition to deals on Mendoza to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mendoza to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mendoza to Santiago.

  • Can I find deals for business class flights from Mendoza to Santiago?

    Yes. Cheapflights offers flight deals from Mendoza to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mendoza to Santiago?

    Currently, June is the cheapest month in which you can book a flight from Mendoza to Santiago (average of $41). Flying from Mendoza to Santiago in September is currently the most expensive (average of $76). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Mendoza to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
Ministro Pistarini to Santiago flights
Jorge Newbery to Santiago flights
Cordoba to Santiago flights
Ushuaia to Santiago flights
Ministro Pistarini to Arica flights

Top 3 airlines flying from Mendoza to Santiago

Discover the top 3 airlines that operate flights from Mendoza to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 26, 2026.
AirlineCheapestAverageFlexibilityOn-time
JetSMARTCheapest$33Average$110FlexibilityNo cancel feeOn-timeN/A
Sky AirlineCheapest$80Average$135FlexibilityNo cancel feeOn-time73%
LATAM AirlinesCheapest$82Average$163FlexibilityNo cancel feeOn-time81%

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