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$66+ Cheap flights from Mendoza (MDZ) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/13. Fares are subject to change and may not be available on all flights or dates of travel.
MDZ — SCL
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheapflights Tip: The best prices from Mendoza El Plumerillo to Santiago Arturo Merino Benitez are usually found in October or November, booked 88 days in advance, depart on a Friday or Saturday and return on a Sunday

Cheap flight deals from Mendoza to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Mendoza (MDZ) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$103
(Mytrip)

One-way from

$66
(Booking.com)

Popular in

January

Cheapest in

October

Average price

$131

Good round-trip deal

$219 or less

Good one-way deal

$82 or less
From Mendoza El Plumerillo to Santiago Arturo Merino Benitez
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One-way flight from Mendoza El Plumerillo to Santiago Arturo Merino Benitez
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Highest demand for flights based on searches. 5% potential increase in price ($6 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($3 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Price to beat on a round-trip flight from Mendoza El Plumerillo to Santiago Arturo Merino Benitez.
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Price to beat on a one-way flight from Mendoza El Plumerillo to Santiago Arturo Merino Benitez.
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Find flight deals from Mendoza to Santiago

Cheapest flights from Mendoza to Santiago
Explore the most affordable flight options available from Mendoza to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This Mytrip deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/83:40 pmMDZ - SCL
Nonstop1h 00mSky Airline
Wed 10/151:45 pmSCL - MDZ
Nonstop1h 05mSky Airline
Deal found 9/9$103
This Mytrip deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/309:00 pmMDZ - SCL
Nonstop1h 00mSky Airline
Tue 12/91:45 pmSCL - MDZ
Nonstop1h 05mSky Airline
Deal found 9/11$105
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1010:20 pmMDZ - SCL
Nonstop0h 56mJetSMART
Sun 10/128:31 pmSCL - MDZ
Nonstop1h 04mJetSMART
Deal found 9/10$110
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/23:40 pmMDZ - SCL
Nonstop1h 05mMultiple Airlines
Mon 1/128:15 amSCL - MDZ
Nonstop1h 05mMultiple Airlines
Deal found 9/10$111
This CheapOair deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/233:40 pmMDZ - SCL
Nonstop1h 00mSky Airline
Mon 10/271:45 pmSCL - MDZ
Nonstop1h 05mSky Airline
Deal found 9/10$114
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1010:20 pmMDZ - SCL
Nonstop0h 56mMultiple Airlines
Wed 10/151:45 pmSCL - MDZ
Nonstop1h 05mMultiple Airlines
Deal found 9/10$115
This Sky Airline deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Sky Airline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/263:40 pmMDZ - SCL
Nonstop1h 01mSky Airline
Fri 10/37:05 pmSCL - MDZ
Nonstop1h 05mSky Airline
Deal found 9/10$116
This Booking.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/23:40 pmMDZ - SCL
Nonstop1h 05mSky Airline
Mon 1/121:45 pmSCL - MDZ
Nonstop1h 05mSky Airline
Deal found 9/11$119
This Mytrip deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/123:40 pmMDZ - SCL
Nonstop1h 05mMultiple Airlines
Sun 1/116:55 amSCL - MDZ
Nonstop1h 05mMultiple Airlines
Deal found 9/11$120
This Expedia deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/2610:20 pmMDZ - SCL
Nonstop1h 00mMultiple Airlines
Sun 11/28:15 amSCL - MDZ
Nonstop1h 05mMultiple Airlines
Deal found 9/11$123
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/103:40 pmMDZ - SCL
Nonstop1h 00mMultiple Airlines
Fri 10/108:31 pmSCL - MDZ
Nonstop1h 04mMultiple Airlines
Deal found 9/10$128

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mendoza to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Mendoza to Santiago that are best for you.

Fly from

Mendoza

Fly to

Santiago

Route

Depart

Return

Price

MendozaSantiago

MDZ - SCL

MDZSCL

Mendoza El Plumerillo

Wed 10/8

3:40 pm-4:40 pm

Nonstop1h 00m

Santiago Arturo Merino Benitez

Wed 10/15

1:45 pm-2:50 pm

Nonstop1h 05m

$103

MendozaSantiago

MDZ - SCL

MDZSCL

Mendoza El Plumerillo

Tue 9/30

9:00 pm-10:00 pm

Nonstop1h 00m

Santiago Arturo Merino Benitez

Tue 12/9

1:45 pm-2:50 pm

Nonstop1h 05m

$105

MendozaSantiago

MDZ - SCL

MDZSCL

Mendoza El Plumerillo

Sat 11/15

3:40 pm-4:45 pm

Nonstop1h 05m

Santiago Arturo Merino Benitez

Mon 12/8

7:05 pm-8:10 pm

Nonstop1h 05m

$114

MendozaSantiago

MDZ - SCL

MDZSCL

Mendoza El Plumerillo

Thu 10/23

3:40 pm-4:40 pm

Nonstop1h 00m

Santiago Arturo Merino Benitez

Mon 10/27

1:45 pm-2:50 pm

Nonstop1h 05m

$114

MendozaSantiago

MDZ - SCL

MDZSCL

Mendoza El Plumerillo

Fri 12/5

3:40 pm-4:45 pm

Nonstop1h 05m

Santiago Arturo Merino Benitez

Mon 12/8

7:05 pm-8:10 pm

Nonstop1h 05m

$114

MendozaSantiago

MDZ - SCL

MDZSCL

Mendoza El Plumerillo

Tue 10/14

3:40 pm-4:40 pm

Nonstop1h 00m

Santiago Arturo Merino Benitez

Fri 10/17

7:05 pm-8:10 pm

Nonstop1h 05m

$114

MendozaSantiago

MDZ - SCL

MDZSCL

Mendoza El Plumerillo

Fri 9/26

3:40 pm-4:41 pm

Nonstop1h 01m

Santiago Arturo Merino Benitez

Fri 10/3

7:05 pm-8:10 pm

Nonstop1h 05m

$116

MendozaSantiago

MDZ - SCL

MDZSCL

Mendoza El Plumerillo

Fri 10/10

3:40 pm-4:40 pm

Nonstop1h 00m

Santiago Arturo Merino Benitez

Fri 10/10

8:31 pm-9:35 pm

Nonstop1h 04m

$128

MendozaSantiago

MDZ - SCL

MDZSCL

Mendoza El Plumerillo

Fri 10/10

9:00 pm-10:00 pm

Nonstop1h 00m

Santiago Arturo Merino Benitez

Mon 10/13

1:45 pm-2:50 pm

Nonstop1h 05m

$136

MendozaSantiago

MDZ - SCL

MDZSCL

Mendoza El Plumerillo

Wed 9/24

9:00 pm-10:01 pm

Nonstop1h 01m

Santiago Arturo Merino Benitez

Wed 10/15

1:45 pm-2:50 pm

Nonstop1h 05m

$136

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Showing 1-10 of 19 results
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Best time to book a flight from Mendoza to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Mendoza with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mendoza to Santiago

How far ahead should I book a flight from Mendoza to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from Mendoza to Santiago. Price data was last updated on August 29, 2025.

The best time to book flights from Mendoza to Santiago is 88 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Mendoza to Santiago?

Currently, April is the cheapest month in which you can book a flight from Mendoza to Santiago (average of $752). Flying from Mendoza to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MDZ to SCL?

Find hourly flight availability from Mendoza to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 11, 2025.

One of the essential ways to save on airfare from Mendoza to Santiago is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the afternoon could potentially save you up to 66% on airfare.

How much does it cost to fly round-trip from Mendoza to Santiago?

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated September 11, 2025.
Peruse reviews from past customers who have flown with LATAM Airlines and JetSMART from Mendoza to Santiago to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
LATAM Airlines
7.5
Good
1,847 reviews

Overall

7.5

Comfort

7.4

Boarding

7.6

Crew

8.0

Food

6.7

Entertainment

7.0

Reviews

1 / 20
8.0
Excellent

Darrel,Sep 2025

LIM - GRU

The Wi-Fi was not working, so there was no in-flight entertainment. The biggest disappointment was that my Delta diamond status did not transfer any status to my LATAM flight. I WOULD’VE THOUGHT THAT THERE WOULD BE A BETTER WORKING AGREEMENT BETWEEN THE AIRLINES.
LATAM Airlines
7.5
Good
1,847 reviews
LATAM Airlines
7.5
Good
1,847 reviews

Overall

7.5

Comfort

7.4

Boarding

7.6

Crew

8.0

Food

6.7

Entertainment

7.0

Reviews

1 / 20
8.0
Excellent

Darrel,Sep 2025

LIM - GRU

The Wi-Fi was not working, so there was no in-flight entertainment. The biggest disappointment was that my Delta diamond status did not transfer any status to my LATAM flight. I WOULD’VE THOUGHT THAT THERE WOULD BE A BETTER WORKING AGREEMENT BETWEEN THE AIRLINES.
JetSMART
6.5
Okay
225 reviews
LATAM Airlines
7.5
Good
1,847 reviews

Overall

7.5

Comfort

7.4

Boarding

7.6

Crew

8.0

Food

6.7

Entertainment

7.0

Reviews

1 / 20
8.0
Excellent

Darrel,Sep 2025

LIM - GRU

The Wi-Fi was not working, so there was no in-flight entertainment. The biggest disappointment was that my Delta diamond status did not transfer any status to my LATAM flight. I WOULD’VE THOUGHT THAT THERE WOULD BE A BETTER WORKING AGREEMENT BETWEEN THE AIRLINES.

Related info for your journey

Find useful and relevant information for your journey from Mendoza to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Mendoza to Santiago?

    If you wish to fly to Santiago from Mendoza, then you need to book flights from Mendoza El Plumerillo to Santiago Arturo Merino Benitez. There is 1 flight from El Plumerillo (MDZ) to Arturo Merino Benitez (SCL) per day to choose from. Flights to Santiago from El Plumerillo are available from 3 different airlines, which means you should have some options if you want to compare airfare deals. 0h 56m is how long a nonstop flight from Mendoza to Santiago Arturo Merino Benitez typically takes.

  • How popular is this Mendoza to Santiago flight route?

    This flight path from Mendoza El Plumerillo to Santiago Arturo Merino Benitez was viewed by 2 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Mendoza to Santiago?

    There are many flights that can get you from Mendoza to Santiago in 1h. Fly via Sky Airline to get the fastest option. The distance between Mendoza and Santiago is about 122 mi. Most flights are nonstop.

  • What are the cheapest airlines flying from Mendoza to Santiago round-trip?

    Cheapflights users have booked flights from Mendoza to Santiago round-trip from $37. Other airlines that can offer you cheap pricing are LATAM Airlines, from $65, and Sky Airline, from $81. Users have found that JetSMART is 72% cheaper than the other options available to this destination.

  • What are the most reliable airlines from Mendoza to Santiago?

    Consider Aerolineas Argentinas (94%), Sky Airline (90%) or Iberia (86%) when booking your flight. These represent the most reliable airlines when flying from Mendoza to Santiago.

  • What are the cheapest flights from Mendoza to Santiago?

    On average you can expect to pay $438 for a flight from Mendoza to Santiago. The cheapest flight overall is $65 while the most popular route, (Mendoza El Plumerillo - Santiago Arturo Merino Benitez) is currently priced at $125.

  • Can I find deals for flights from Mendoza to Santiago that include hotel bookings?

    Yes. In addition to deals on Mendoza to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mendoza to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mendoza to Santiago.

  • Can I find deals for business class flights from Mendoza to Santiago?

    Yes. Cheapflights offers flight deals from Mendoza to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mendoza to Santiago?

    Currently, April is the cheapest month in which you can book a flight from Mendoza to Santiago (average of $752). Flying from Mendoza to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Mendoza to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
Ministro Pistarini to Santiago flights
Jorge Newbery to Santiago flights
Cordoba to Santiago flights
Ushuaia to Santiago flights
Ministro Pistarini to Arica flights

Top 3 airlines flying from Mendoza to Santiago

Discover the top 3 airlines that operate flights from Mendoza to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
JetSMARTCheapest$37Average$115FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$65Average$147FlexibilityNo cancel feeOn-time81%
Sky AirlineCheapest$81Average$122FlexibilityNo cancel feeOn-time73%

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