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$300+ Cheap flights from Detroit (DTT) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/14. Fares are subject to change and may not be available on all flights or dates of travel.
DTT — SCL
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
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Find flight deals from Detroit to Santiago

Cheapest flights from Detroit to Santiago
Explore the most affordable flight options available from Detroit to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This Mytrip deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/273:43 pmDTW - SCL
3 stops28h 32mMultiple Airlines
Thu 12/49:10 pmSCL - DTW
2 stops20h 24mMultiple Airlines
Deal found 10/30$629
This Mytrip deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/126:00 amDTW - SCL
3 stops30h 40mMultiple Airlines
Mon 12/156:00 amSCL - DTW
3 stops27h 44mMultiple Airlines
Deal found 10/30$691
This Mytrip deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/269:53 pmDTW - SCL
3 stops30h 32mMultiple Airlines
Sat 12/69:10 pmSCL - DTW
3 stops28h 49mMultiple Airlines
Deal found 10/29$721

Cheap flight deals from Detroit to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Detroit (DTT) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 30, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$629
(Mytrip)

One-way from

$300
(Kiwi.com)

Popular in

December

Cheapest in

October

Average price

$873
Provider with most accurate pricing for Detroit (DTT)-Santiago Arturo Merino Benitez flight deals.
Search Deals
Provider most trusted by Cheapflights users for Detroit (DTT)-Santiago Arturo Merino Benitez flights.
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From Detroit (DTT) to Santiago Arturo Merino Benitez
Search Deals
One-way flight from Detroit (DTT) to Santiago Arturo Merino Benitez
Search Deals
Highest demand for flights based on searches. 4% potential increase in price ($52 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($16 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Detroit to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Detroit to Santiago that are best for you.

Fly from

Detroit

Fly to

Santiago

Route

Depart

Return

Price

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Thu 11/27

7:10 am-10:15 pm

2 stops37h 05m

Santiago Arturo Merino Benitez

Thu 12/4

11:25 pm-3:34 pm

1 stop18h 09m

$634

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Wed 1/28

7:58 am-10:39 am

2 stops24h 41m

Santiago Arturo Merino Benitez

Wed 2/4

9:05 pm-2:09 pm

2 stops19h 04m

$680

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Fri 1/2

7:45 am-6:40 am

2 stops20h 55m

Santiago Arturo Merino Benitez

Sat 1/10

11:24 am-3:40 pm

3 stops30h 16m

$725

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Fri 12/12

6:00 am-2:34 pm

2 stops30h 34m

Santiago Arturo Merino Benitez

Mon 12/15

11:24 am-10:08 am

2 stops24h 44m

$762

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Tue 1/6

11:30 am-8:15 am

2 stops18h 45m

Santiago Arturo Merino Benitez

Tue 1/20

11:15 pm-2:01 pm

2 stops16h 46m

$869

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Sun 12/14

5:50 am-4:55 am

3 stops21h 05m

$300

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Sun 3/1

12:35 pm-10:15 pm

3 stops31h 40m

$309

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Wed 2/25

4:40 pm-8:50 am

1 stop14h 10m

$543

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Thu 2/26

11:00 am-8:50 am

1 stop19h 50m

$543

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Thu 3/26

10:49 am-7:50 am

1 stop20h 01m

$543

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/30

Showing 1-10 of 11 results
1
2

Compare providers for flights from Detroit to Santiago

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Detroit to Santiago in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
AranGrantPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Detroit-Santiago flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Detroit-Santiago flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Detroit-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Detroit-Santiago flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Detroit-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Detroit to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Detroit with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Detroit to Santiago

What is the cheapest time of day to fly from DTT to SCL?

Find hourly flight availability from Detroit to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 30, 2025.

A simple way to save on the total cost of your ticket is to fly from Detroit to Santiago in the evening. If you’re flexible enough to do this you can expect to save up to 18% on your trip compared to booking a flight at noon.

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated October 30, 2025.
Read through reviews of airlines operating flights from Detroit to Santiago, such as Delta and LATAM Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,993 reviews

Boarding

8.2

Crew

8.5

Overall

7.9

Food

7.3

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
7.9
Good
7,993 reviews
Delta
7.9
Good
7,993 reviews

Boarding

8.2

Crew

8.5

Overall

7.9

Food

7.3

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
LATAM Airlines
7.5
Good
1,872 reviews
Delta
7.9
Good
7,993 reviews

Boarding

8.2

Crew

8.5

Overall

7.9

Food

7.3

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Detroit to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Detroit to Santiago round-trip?

    According to our current data, Air Canada ($684), LATAM Airlines ($733), and Delta ($768) offers the cheapest pricing from Detroit to Santiago. You may be able to fly from Detroit to Santiago for 33% less than the average price by searching for these airlines.

  • Can I find deals for flights from Detroit to Santiago that include hotel bookings?

    Yes. In addition to deals on Detroit to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Detroit to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Detroit to Santiago.

  • Can I find deals for business class flights from Detroit to Santiago?

    Yes. Cheapflights offers flight deals from Detroit to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Top 4 airlines flying from Detroit to Santiago

Discover the top 4 airlines that operate flights from Detroit to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
Air CanadaCheapest$684Average$946FlexibilityNo cancel feeOn-time67%
LATAM AirlinesCheapest$733Average$1,418FlexibilityNo cancel feeOn-time81%
DeltaCheapest$768Average$1,273FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$822Average$1,047FlexibilityNo cancel feeOn-time71%

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