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$450+ Cheap flights from Buffalo (BUF) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/16. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — SCL
Mar 21 — Mar 281
Sat 3/21
Sat 3/28
1 adult, Economy
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Cheap flight deals from Buffalo to Santiago

Cheapest flights from Buffalo to Santiago
Explore the most affordable flight options available from Buffalo to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 19, 2026.

This KAYAK deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:00 am
BUF
-
SCL
2 stops19h 25m
LATAM Airlines
Thu 11/197:45 am
SCL
-
BUF
2 stops18h 10m
LATAM Airlines
Deal found 2/17$825
This KAYAK deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/183:50 pm
BUF
-
SCL
1 stop14h 00m
LATAM Airlines
Sun 10/254:50 pm
SCL
-
BUF
2 stops20h 43m
LATAM Airlines
Deal found 2/15$845
This LATAM Airlines deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2212:09 pm
BUF
-
SCL
2 stops16h 41m
LATAM Airlines
Wed 4/298:40 pm
SCL
-
BUF
1 stop14h 21m
LATAM Airlines
Deal found 2/17$858
This LATAM Airlines deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/134:00 pm
BUF
-
SCL
1 stop13h 50m
LATAM Airlines
Thu 12/246:45 pm
SCL
-
BUF
2 stops18h 30m
LATAM Airlines
Deal found 2/18$865
This LATAM Airlines deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/196:00 am
BUF
-
SCL
2 stops21h 30m
LATAM Airlines
Mon 3/234:20 pm
SCL
-
BUF
2 stops27h 23m
LATAM Airlines
Deal found 2/18$873
This KAYAK deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/187:59 pm
BUF
-
SCL
1 stop33h 51m
Multiple Airlines
Sun 10/2510:55 pm
SCL
-
BUF
1 stop20h 19m
Multiple Airlines
Deal found 2/17$880
This LATAM Airlines deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/23:56 pm
BUF
-
SCL
1 stop14h 29m
LATAM Airlines
Sat 4/1110:55 pm
SCL
-
BUF
1 stop16h 19m
LATAM Airlines
Deal found 2/15$883
This Delta deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/212:07 pm
BUF
-
SCL
2 stops17h 53m
Delta
Sat 4/1110:55 pm
SCL
-
BUF
1 stop16h 19m
Delta
Deal found 2/16$898

Find flight deals from Buffalo to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Buffalo (BUF) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 19, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$858
(LATAM Airlines)

One-way from

$450
(FlightHub)
Provider with most accurate pricing for Buffalo-Santiago Arturo Merino Benitez flight deals.
Search Deals
Provider most trusted by Cheapflights users for Buffalo-Santiago Arturo Merino Benitez flights.
Search Deals
From Buffalo to Santiago Arturo Merino Benitez
Search Deals
One-way flight from Buffalo to Santiago Arturo Merino Benitez
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Buffalo to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 19, 2026.
Use the filters below to find and compare flights from Buffalo to Santiago that are best for you.

Fly from

Buffalo

Fly to

Santiago

Route

Depart

Return

Price

BuffaloSantiago

BUF - SCL

BUFSCL

Buffalo

Wed 4/22

12:09 pm-4:50 am

2 stops16h 41m

Santiago Arturo Merino Benitez

Wed 4/29

8:40 pm-11:01 am

1 stop14h 21m

$858

BuffaloSantiago

BUF - SCL

BUFSCL

Buffalo

Thu 3/19

3:56 pm-5:55 am

1 stop12h 59m

Santiago Arturo Merino Benitez

Mon 3/23

4:20 pm-11:46 pm

2 stops32h 26m

$873

BuffaloSantiago

BUF - SCL

BUFSCL

Buffalo

Thu 4/2

3:56 pm-7:25 am

1 stop14h 29m

Santiago Arturo Merino Benitez

Sat 4/11

10:55 pm-3:14 pm

1 stop16h 19m

$883

BuffaloSantiago

BUF - SCL

BUFSCL

Buffalo

Thu 4/2

12:07 pm-7:00 am

2 stops17h 53m

Santiago Arturo Merino Benitez

Sat 4/11

10:55 pm-7:16 pm

1 stop20h 21m

$898

BuffaloSantiago

BUF - SCL

BUFSCL

Buffalo

Mon 3/16

12:07 pm-7:40 am

1 stop18h 33m

$450

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/15

Compare providers for flights from Buffalo to Santiago

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Buffalo to Santiago in February.
ProviderPrice AccuracyTrust Score*
FlightHubPrice Accuracy3 starsTrust Score*3 stars
JustAirTicketPrice Accuracy-Trust Score*1 star
SmartFaresPrice Accuracy1 starTrust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Buffalo-Santiago flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Buffalo-Santiago flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Buffalo-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Buffalo-Santiago flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Buffalo-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Buffalo to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Buffalo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated February 19, 2026.
Get a feel of what it's like to fly with LATAM Airlines from Buffalo to Santiago by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
LATAM Airlines
7.5
Good
1,921 reviews

Food

6.7

Comfort

7.3

Crew

8.0

Entertainment

7.0

Boarding

7.5

Overall

7.5

Reviews

1 / 20
8.0
Excellent

LUIS JOSE,Oct 2025

LIM - AEP

Smiles because se upgraded to premiums economy. That was similar to LAN economy years ahí!
LATAM Airlines
7.5
Good
1,921 reviews
LATAM Airlines
7.5
Good
1,921 reviews

Food

6.7

Comfort

7.3

Crew

8.0

Entertainment

7.0

Boarding

7.5

Overall

7.5

Reviews

1 / 20
8.0
Excellent

LUIS JOSE,Oct 2025

LIM - AEP

Smiles because se upgraded to premiums economy. That was similar to LAN economy years ahí!

Related info for your journey

Find useful and relevant information for your journey from Buffalo to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Buffalo to Santiago?

    LATAM Airlines can get you from Buffalo to Santiago in just under 16h 41m. Your travel time can differ by up to . The distance between Buffalo and Santiago is about 5294 mi.

  • What is the cheapest airline to fly from Buffalo to Santiago round-trip?

    Flying on LATAM Airlines is currently your cheapest option to Santiago, with prices starting at $763.

  • Can I find deals for flights from Buffalo to Santiago that include hotel bookings?

    Yes. In addition to deals on Buffalo to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Buffalo to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to Santiago.

  • Can I find deals for business class flights from Buffalo to Santiago?

    Yes. Cheapflights offers flight deals from Buffalo to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Top airline flying from Buffalo to Santiago

Discover the top airline that operate flights from Buffalo to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 19, 2026.
AirlineCheapestAverageFlexibilityOn-time
LATAM AirlinesCheapest$763Average$842FlexibilityNo cancel feeOn-time81%

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