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$574+ Cheap flights from Buffalo (BUF) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/22. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — SCL
Dec 26 — Jan 21
Fri 12/26
Fri 1/2
1 adult, Economy
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Find flight deals from Buffalo to Santiago

Cheapest flights from Buffalo to Santiago
Explore the most affordable flight options available from Buffalo to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 26, 2025.

This Delta deal was found by Cheapflights users on 11/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/67:59 pmBUF - SCL
2 stops16h 06mDelta
Tue 12/94:35 amSCL - BUF
2 stops21h 24mDelta
Deal found 11/23$804
This KAYAK deal was found by Cheapflights users on 11/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/263:50 pmBUF - SCL
1 stop13h 05mLATAM Airlines
Fri 1/911:25 pmSCL - BUF
2 stops15h 49mLATAM Airlines
Deal found 11/26$1,514
This Delta deal was found by Cheapflights users on 11/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/266:10 amBUF - SCL
2 stops23h 30mDelta
Fri 1/911:25 pmSCL - BUF
2 stops22h 27mDelta
Deal found 11/26$1,702

Cheap flight deals from Buffalo to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Buffalo (BUF) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 26, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$804
(Delta)

One-way from

$574
(FlightHub)
Provider with most accurate pricing for Buffalo-Santiago Arturo Merino Benitez flight deals.
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Provider most trusted by Cheapflights users for Buffalo-Santiago Arturo Merino Benitez flights.
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From Buffalo to Santiago Arturo Merino Benitez
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One-way flight from Buffalo to Santiago Arturo Merino Benitez
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Buffalo to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 26, 2025.
Use the filters below to find and compare flights from Buffalo to Santiago that are best for you.

Fly from

Buffalo

Fly to

Santiago

Route

Depart

Return

Price

BuffaloSantiago

BUF - SCL

BUFSCL

Buffalo

Sat 12/6

3:55 pm-6:55 am

1 stop13h 00m

Santiago Arturo Merino Benitez

Wed 12/10

5:15 am-11:59 pm

2 stops20h 44m

$804

BuffaloSantiago

BUF - SCL

BUFSCL

Buffalo

Sat 12/6

7:59 pm-2:05 pm

2 stops16h 06m

Santiago Arturo Merino Benitez

Tue 12/9

4:35 am-11:59 pm

2 stops21h 24m

$804

BuffaloSantiago

BUF - SCL

BUFSCL

Buffalo

Thu 1/29

3:38 pm-6:55 am

1 stop13h 17m

$574

BuffaloSantiago

BUF - SCL

BUFSCL

Buffalo

Tue 2/3

3:38 pm-6:55 am

1 stop13h 17m

$574

BuffaloSantiago

BUF - SCL

BUFSCL

Buffalo

Thu 1/22

12:13 pm-7:40 am

1 stop17h 27m

$574

BuffaloSantiago

BUF - SCL

BUFSCL

Buffalo

Mon 2/2

6:00 am-7:40 am

1 stop23h 40m

$574

BuffaloSantiago

BUF - SCL

BUFSCL

Buffalo

Fri 1/23

12:13 pm-6:10 am

1 stop15h 57m

$615

BuffaloSantiago

BUF - SCL

BUFSCL

Buffalo

Sun 2/1

3:38 pm-6:55 am

1 stop13h 17m

$615

BuffaloSantiago

BUF - SCL

BUFSCL

Buffalo

Sat 1/31

3:43 pm-6:55 am

1 stop13h 12m

$615

BuffaloSantiago

BUF - SCL

BUFSCL

Buffalo

Fri 1/30

3:38 pm-6:55 am

1 stop13h 17m

$615

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/26

Showing 1-10 of 11 results
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Compare providers for flights from Buffalo to Santiago

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Buffalo to Santiago in November.
ProviderPrice AccuracyTrust Score*
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars
AranGrantPrice Accuracy2 starsTrust Score*3 stars
JustAirTicketPrice Accuracy-Trust Score*1 star
SmartFaresPrice Accuracy1 starTrust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Buffalo-Santiago flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Buffalo-Santiago flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Buffalo-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Buffalo-Santiago flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Buffalo-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Buffalo to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Buffalo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated November 26, 2025.
Get a feel of what it's like to fly with LATAM Airlines from Buffalo to Santiago by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
LATAM Airlines
7.5
Good
1,886 reviews

Comfort

7.3

Crew

8.0

Overall

7.5

Food

6.7

Entertainment

7.0

Boarding

7.6

Reviews

1 / 20
8.0
Excellent

LUIS JOSE,Oct 2025

LIM - AEP

Smiles because se upgraded to premiums economy. That was similar to LAN economy years ahí!
LATAM Airlines
7.5
Good
1,886 reviews
LATAM Airlines
7.5
Good
1,886 reviews

Comfort

7.3

Crew

8.0

Overall

7.5

Food

6.7

Entertainment

7.0

Boarding

7.6

Reviews

1 / 20
8.0
Excellent

LUIS JOSE,Oct 2025

LIM - AEP

Smiles because se upgraded to premiums economy. That was similar to LAN economy years ahí!

Related info for your journey

Find useful and relevant information for your journey from Buffalo to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Buffalo to Santiago?

    Delta and LATAM Airlines can get you from Buffalo to Santiago in just under 14h 04m. Your travel time can differ by up to 2h 02m. The distance between Buffalo and Santiago is about 5294 mi. This flight may include one or multiple stops.

  • What is the cheapest airline to fly from Buffalo to Santiago round-trip?

    Flying on LATAM Airlines is currently your cheapest option to Santiago, with prices starting at $763.

  • Can I find deals for flights from Buffalo to Santiago that include hotel bookings?

    Yes. In addition to deals on Buffalo to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Buffalo to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to Santiago.

  • Can I find deals for business class flights from Buffalo to Santiago?

    Yes. Cheapflights offers flight deals from Buffalo to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top airline flying from Buffalo to Santiago

Discover the top airline that operate flights from Buffalo to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 26, 2025.
AirlineCheapestAverageFlexibilityOn-time
LATAM AirlinesCheapest$763Average$844FlexibilityNo cancel feeOn-time81%

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