HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Santiago

$769+ Cheap flights from Buffalo (BUF) to Santiago (SCL)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/11. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — SCL
Nov 15 — Nov 221
Sat 11/15
Sat 11/22
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Buffalo to Santiago with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Find flight deals from Buffalo to Santiago

Cheapest flights from Buffalo to Santiago
Explore the most affordable flight options available from Buffalo to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 16, 2025.

This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1112:53 pmBUF - SCL
2 stops18h 07mAmerican Airlines
Tue 11/1811:15 pmSCL - BUF
1 stop19h 11mAmerican Airlines
Deal found 10/15$769
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/286:12 amBUF - SCL
1 stop23h 48mAmerican Airlines
Wed 12/311:15 pmSCL - BUF
1 stop25h 22mAmerican Airlines
Deal found 10/15$817
This KAYAK deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/113:45 pmBUF - SCL
1 stop13h 10mLATAM Airlines
Tue 11/1811:30 pmSCL - BUF
1 stop17h 35mLATAM Airlines
Deal found 10/15$1,086
This LATAM Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/287:00 amBUF - SCL
3 stops26h 05mMultiple Airlines
Wed 12/38:50 pmSCL - BUF
2 stops25h 54mMultiple Airlines
Deal found 10/15$1,164
This Copa Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/117:30 pmBUF - SCL
2 stops26h 11mCopa Airlines
Mon 11/173:23 amSCL - BUF
2 stops32h 25mCopa Airlines
Deal found 10/15$1,277
This KAYAK deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/266:00 amBUF - SCL
3 stops30h 25mLATAM Airlines
Thu 1/812:20 amSCL - BUF
2 stops25h 37mLATAM Airlines
Deal found 10/15$1,373
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/2612:50 pmBUF - SCL
2 stops18h 35mAmerican Airlines
Fri 1/911:15 pmSCL - BUF
1 stop23h 51mAmerican Airlines
Deal found 10/16$1,469

Cheap flight deals from Buffalo to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Buffalo (BUF) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 16, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$764
(LATAM Airlines)
Provider with most accurate pricing for Buffalo-Santiago Arturo Merino Benitez flight deals.
Search Deals
Provider most trusted by Cheapflights users for Buffalo-Santiago Arturo Merino Benitez flights.
Search Deals
From Buffalo to Santiago Arturo Merino Benitez
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Buffalo to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 16, 2025.
Use the filters below to find and compare flights from Buffalo to Santiago that are best for you.

Fly from

Buffalo

Fly to

Santiago

Route

Depart

Return

Price

BuffaloSantiago

BUF - SCL

BUFSCL

Buffalo

Tue 11/11

12:53 pm-9:00 am

2 stops18h 07m

Santiago Arturo Merino Benitez

Tue 11/18

11:15 pm-4:26 pm

1 stop19h 11m

$769

BuffaloSantiago

BUF - SCL

BUFSCL

Buffalo

Thu 4/2

12:09 pm-6:50 am

2 stops17h 41m

Santiago Arturo Merino Benitez

Sun 4/12

11:25 pm-11:58 pm

2 stops24h 33m

$804

BuffaloSantiago

BUF - SCL

BUFSCL

Buffalo

Wed 4/1

12:09 pm-4:30 am

2 stops15h 21m

Santiago Arturo Merino Benitez

Sun 4/12

11:25 pm-11:58 pm

2 stops24h 33m

$804

BuffaloSantiago

BUF - SCL

BUFSCL

Buffalo

Tue 3/31

12:09 pm-5:45 am

2 stops16h 36m

Santiago Arturo Merino Benitez

Sun 4/12

11:25 pm-11:58 pm

2 stops24h 33m

$804

BuffaloSantiago

BUF - SCL

BUFSCL

Buffalo

Wed 4/1

6:50 pm-8:00 am

1 stop12h 10m

Santiago Arturo Merino Benitez

Sun 4/12

11:25 pm-11:58 pm

2 stops24h 33m

$804

BuffaloSantiago

BUF - SCL

BUFSCL

Buffalo

Wed 4/1

6:50 pm-8:00 am

1 stop12h 10m

Santiago Arturo Merino Benitez

Fri 4/10

5:35 am-11:57 pm

2 stops18h 22m

$844

BuffaloSantiago

BUF - SCL

BUFSCL

Buffalo

Tue 3/31

12:09 pm-6:50 am

2 stops17h 41m

Santiago Arturo Merino Benitez

Fri 4/10

5:35 am-11:57 pm

2 stops18h 22m

$844

BuffaloSantiago

BUF - SCL

BUFSCL

Buffalo

Thu 4/2

12:09 pm-8:00 am

1 stop18h 51m

Santiago Arturo Merino Benitez

Sat 4/11

7:15 am-11:16 am

3 stops28h 01m

$849

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/15

Compare providers for flights from Buffalo to Santiago

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Buffalo to Santiago in October.
ProviderPrice AccuracyTrust Score*
FlightHubPrice Accuracy3 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars
AranGrantPrice Accuracy3 starsTrust Score*3 stars
JustAirTicketPrice Accuracy-Trust Score*3 stars
SmartFaresPrice Accuracy1 starTrust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Buffalo-Santiago flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Buffalo-Santiago flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Buffalo-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Buffalo-Santiago flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Buffalo-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Buffalo to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Buffalo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated October 16, 2025.
Get a feel of what it's like to fly with LATAM Airlines from Buffalo to Santiago by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
LATAM Airlines
7.5
Good
1,866 reviews

Comfort

7.3

Crew

8.0

Overall

7.5

Boarding

7.6

Entertainment

7.0

Food

6.7

Reviews

1 / 20
8.0
Excellent

LUIS JOSE,Oct 2025

LIM - AEP

Smiles because se upgraded to premiums economy. That was similar to LAN economy years ahí!
LATAM Airlines
7.5
Good
1,866 reviews
LATAM Airlines
7.5
Good
1,866 reviews

Comfort

7.3

Crew

8.0

Overall

7.5

Boarding

7.6

Entertainment

7.0

Food

6.7

Reviews

1 / 20
8.0
Excellent

LUIS JOSE,Oct 2025

LIM - AEP

Smiles because se upgraded to premiums economy. That was similar to LAN economy years ahí!

Related info for your journey

Find useful and relevant information for your journey from Buffalo to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Buffalo to Santiago?

    American Airlines, Delta, and LATAM Airlines can get you from Buffalo to Santiago in just under 15h 21m. Your travel time can differ by up to 2h 46m. The distance between Buffalo and Santiago is about 5294 mi. This flight may include one or multiple stops.

  • What is the cheapest airline to fly from Buffalo to Santiago round-trip?

    Flying on LATAM Airlines is currently your cheapest option to Santiago, with prices starting at $763.

  • Can I find deals for flights from Buffalo to Santiago that include hotel bookings?

    Yes. In addition to deals on Buffalo to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Buffalo to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to Santiago.

  • Can I find deals for business class flights from Buffalo to Santiago?

    Yes. Cheapflights offers flight deals from Buffalo to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top airline flying from Buffalo to Santiago

Discover the top airline that operate flights from Buffalo to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
LATAM AirlinesCheapest$763Average$1,251FlexibilityNo cancel feeOn-time81%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.