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$732+ Cheap flights from Buffalo (BUF) to Santiago (SCL)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/8. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — SCL
Oct 16 — Oct 231
Thu 10/16
Thu 10/23
1 adult, Economy
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Cheap flight deals from Buffalo to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Buffalo (BUF) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 16, 2025.

Round-trip from

$732
(LATAM Airlines)
From Buffalo to Santiago Arturo Merino Benitez
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Find flight deals from Buffalo to Santiago

Cheapest flights from Buffalo to Santiago
Explore the most affordable flight options available from Buffalo to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

This LATAM Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/83:57 pmBUF - SCL
1 stop12h 48mLATAM Airlines
Tue 10/1410:55 pmSCL - BUF
1 stop17h 15mLATAM Airlines
Deal found 9/15$732
This LATAM Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/86:00 amBUF - SCL
1 stop22h 45mMultiple Airlines
Mon 10/1312:10 amSCL - BUF
2 stops35h 51mMultiple Airlines
Deal found 9/15$772
This FlightHub deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/266:55 pmBUF - SCL
1 stop34h 45mLATAM Airlines
Thu 1/812:25 amSCL - BUF
2 stops38h 37mLATAM Airlines
Deal found 9/15$1,173
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/1512:43 pmBUF - SCL
2 stops18h 12mAmerican Airlines
Thu 1/811:55 pmSCL - BUF
2 stops20h 09mAmerican Airlines
Deal found 9/14$1,332
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/1512:43 pmBUF - SCL
2 stops18h 12mAmerican Airlines
Sun 1/1110:15 pmSCL - BUF
2 stops44h 15mAmerican Airlines
Deal found 9/14$1,371
This LATAM Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/153:55 pmBUF - SCL
1 stop13h 00mLATAM Airlines
Wed 1/76:30 pmSCL - BUF
2 stops18h 46mLATAM Airlines
Deal found 9/14$1,396
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/1512:43 pmBUF - SCL
2 stops18h 12mAmerican Airlines
Wed 1/710:15 pmSCL - BUF
2 stops18h 09mAmerican Airlines
Deal found 9/14$1,397

Cheapflights Fare Finder

 
Customize your flight search to find flights from Buffalo to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
Use the filters below to find and compare flights from Buffalo to Santiago that are best for you.

Fly from

Buffalo

Fly to

Santiago

Route

Depart

Return

Price

BuffaloSantiago

BUF - SCL

BUFSCL

Buffalo

Wed 10/8

3:57 pm-5:45 am

1 stop12h 48m

Santiago Arturo Merino Benitez

Tue 10/14

10:55 pm-3:10 pm

1 stop17h 15m

$732

BuffaloSantiago

BUF - SCL

BUFSCL

Buffalo

Wed 10/8

6:00 am-5:45 am

1 stop22h 45m

Santiago Arturo Merino Benitez

Mon 10/13

12:10 am-11:01 am

2 stops35h 51m

$772

BuffaloSantiago

BUF - SCL

BUFSCL

Buffalo

Fri 12/26

6:55 pm-7:40 am

1 stop34h 45m

Santiago Arturo Merino Benitez

Thu 1/8

12:25 am-1:02 pm

2 stops38h 37m

$1,173

BuffaloSantiago

BUF - SCL

BUFSCL

Buffalo

Mon 12/15

12:43 pm-8:55 am

2 stops18h 12m

Santiago Arturo Merino Benitez

Thu 1/8

11:55 pm-6:04 pm

2 stops20h 09m

$1,332

BuffaloSantiago

BUF - SCL

BUFSCL

Buffalo

Mon 12/15

12:43 pm-8:55 am

2 stops18h 12m

Santiago Arturo Merino Benitez

Sun 1/11

10:15 pm-4:30 pm

2 stops44h 15m

$1,371

BuffaloSantiago

BUF - SCL

BUFSCL

Buffalo

Tue 12/16

6:00 am-6:40 am

2 stops22h 40m

Santiago Arturo Merino Benitez

Wed 1/7

6:30 pm-11:16 am

2 stops18h 46m

$1,396

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Best time to book a flight from Buffalo to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Buffalo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Buffalo to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Buffalo to Santiago?

    LATAM Airlines can get you from Buffalo to Santiago in just under 12h 48m. Your travel time can differ by up to . The distance between Buffalo and Santiago is about 5294 mi.

  • Can I find deals for flights from Buffalo to Santiago that include hotel bookings?

    Yes. In addition to deals on Buffalo to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Buffalo to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to Santiago.

  • Can I find deals for business class flights from Buffalo to Santiago?

    Yes. Cheapflights offers flight deals from Buffalo to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Buffalo to Santiago?

    Currently, April is the cheapest month in which you can book a flight from Buffalo to Santiago (average of $752). Flying from Buffalo to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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