HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Santa Cruz de la Sierra

$788+ Cheap flights from St. Louis (STL) to Santa Cruz de la Sierra (VVI)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/23. Fares are subject to change and may not be available on all flights or dates of travel.
STL — VVI
Feb 26 — Mar 51
Thu 2/26
Thu 3/5
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from St. Louis to Santa Cruz de la Sierra with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from St. Louis to Santa Cruz de la Sierra

Cheapest flights from St. Louis to Santa Cruz de la Sierra
Explore the most affordable flight options available from St. Louis to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 27, 2026.

This United Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/238:17 am
STL
-
VVI
2 stops36h 33m
United Airlines
Thu 2/2611:44 am
VVI
-
STL
2 stops23h 39m
United Airlines
Deal found 1/26$788
This KAYAK deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/166:25 am
STL
-
VVI
2 stops38h 25m
Copa Airlines
Mon 3/911:54 am
VVI
-
STL
2 stops23h 18m
Copa Airlines
Deal found 1/25$871
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/147:41 am
STL
-
VVI
2 stops38h 09m
United Airlines
Thu 3/1911:42 am
VVI
-
STL
2 stops46h 39m
United Airlines
Deal found 1/27$1,120
This BusinessClass deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/1512:15 pm
STL
-
VVI
2 stops14h 16m
Copa Airlines
Sat 3/211:14 am
VVI
-
STL
2 stops19h 00m
Copa Airlines
Deal found 1/26$1,401
This FlightHub deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/49:59 am
STL
-
VVI
2 stops40h 36m
LATAM Airlines
Wed 3/47:26 am
VVI
-
STL
2 stops27h 40m
LATAM Airlines
Deal found 1/25$1,419
This KAYAK deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/156:20 pm
STL
-
VVI
2 stops39h 55m
GOL
Sun 3/2212:15 pm
VVI
-
STL
2 stops23h 17m
GOL
Deal found 1/27$2,207
This FlightHub deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/278:25 am
STL
-
VVI
2 stops17h 19m
Multiple Airlines
Sat 1/93:40 am
VVI
-
STL
2 stops16h 53m
Multiple Airlines
Deal found 1/25$2,601
This FlightHub deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/289:30 am
STL
-
VVI
2 stops16h 14m
Multiple Airlines
Sun 1/103:40 am
VVI
-
STL
2 stops16h 53m
Multiple Airlines
Deal found 1/25$2,894

Find flight deals from St. Louis to Santa Cruz de la Sierra

Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Santa Cruz de la Sierra (VVI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 27, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$788
(United Airlines)
Provider with most accurate pricing for Lambert-St Louis-Santa Cruz de la Sierra Viru Viru Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-Santa Cruz de la Sierra Viru Viru Intl flights.
Search Deals
From Lambert-St Louis to Santa Cruz de la Sierra Viru Viru Intl
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from St. Louis to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 27, 2026.
Use the filters below to find and compare flights from St. Louis to Santa Cruz de la Sierra that are best for you.

Fly from

St. Louis

Fly to

Santa Cruz de la Sierra

Route

Depart

Return

Price

St. LouisSanta Cruz de la Sierra

STL - VVI

STLVVI

Lambert-St Louis

Mon 2/23

6:55 pm-10:50 pm

2 stops25h 55m

Santa Cruz de la Sierra Viru Viru Intl

Thu 2/26

11:44 am-10:14 pm

2 stops36h 30m

$788

St. LouisSanta Cruz de la Sierra

STL - VVI

STLVVI

Lambert-St Louis

Mon 2/16

6:25 am-3:44 am

2 stops19h 19m

Santa Cruz de la Sierra Viru Viru Intl

Mon 3/9

11:42 am-10:12 am

2 stops23h 30m

$788

St. LouisSanta Cruz de la Sierra

STL - VVI

STLVVI

Lambert-St Louis

Mon 2/16

6:25 am-10:50 pm

2 stops38h 25m

Santa Cruz de la Sierra Viru Viru Intl

Mon 3/9

11:54 am-10:12 am

2 stops23h 18m

$871

St. LouisSanta Cruz de la Sierra

STL - VVI

STLVVI

Lambert-St Louis

Sat 3/14

7:41 am-10:50 pm

2 stops38h 09m

Santa Cruz de la Sierra Viru Viru Intl

Thu 3/19

11:42 am-9:21 am

2 stops46h 39m

$1,120

St. LouisSanta Cruz de la Sierra

STL - VVI

STLVVI

Lambert-St Louis

Sun 3/15

12:15 pm-3:31 am

2 stops14h 16m

Santa Cruz de la Sierra Viru Viru Intl

Sat 3/21

1:14 am-7:14 pm

2 stops19h 00m

$1,401

St. LouisSanta Cruz de la Sierra

STL - VVI

STLVVI

Lambert-St Louis

Sun 3/15

6:20 pm-11:15 am

2 stops39h 55m

Santa Cruz de la Sierra Viru Viru Intl

Sun 3/22

12:15 pm-10:32 am

2 stops23h 17m

$2,207

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/24

Compare providers for flights from St. Louis to Santa Cruz de la Sierra

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Santa Cruz de la Sierra in January.
ProviderPrice AccuracyTrust Score*
FlightHubPrice Accuracy3 starsTrust Score*3 stars
ExpediaPrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on St. Louis-Santa Cruz de la Sierra flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on St. Louis-Santa Cruz de la Sierra flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from St. Louis-Santa Cruz de la Sierra flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on St. Louis-Santa Cruz de la Sierra flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Santa Cruz de la Sierra flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from St. Louis to Santa Cruz de la Sierra

Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Santa Cruz de la Sierra

Get insights into the airlines that provide service to Santa Cruz de la Sierra. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Cruz de la Sierra. Reviews last updated January 27, 2026.
Get a feel of what it's like to fly with United Airlines from St. Louis to Santa Cruz de la Sierra by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,205 reviews

Entertainment

7.1

Crew

8.1

Food

6.6

Overall

7.4

Comfort

7.3

Boarding

7.7

Reviews

1 / 20
10.0
Excellent

Dane,Jan 2026

TYS - IAD

It was a short flight, so no time for amenities. Just glad everything was quick and easy from boarding to arriving at my destination with my family
United Airlines
7.4
Good
9,205 reviews
United Airlines
7.4
Good
9,205 reviews

Entertainment

7.1

Crew

8.1

Food

6.6

Overall

7.4

Comfort

7.3

Boarding

7.7

Reviews

1 / 20
10.0
Excellent

Dane,Jan 2026

TYS - IAD

It was a short flight, so no time for amenities. Just glad everything was quick and easy from boarding to arriving at my destination with my family

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from St. Louis to Santa Cruz de la Sierra?

    A quick flight from St. Louis to Santa Cruz de la Sierra can take about 25h 55m. United Airlines provides one of the quickest options available for as low as $788. St. Louis and Santa Cruz de la Sierra are separated by a distance of 4274 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from St. Louis to Santa Cruz de la Sierra that include hotel bookings?

    Yes. In addition to deals on St. Louis to Santa Cruz de la Sierra flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to Santa Cruz de la Sierra?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Santa Cruz de la Sierra.

  • Can I find deals for business class flights from St. Louis to Santa Cruz de la Sierra?

    Yes. Cheapflights offers flight deals from St. Louis to Santa Cruz de la Sierra by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for St. Louis to Santa Cruz de la Sierra

See prices for flight routes from nearby airports that may be better suited for you.
St. Louis to La Paz flights
Kansas City to Santa Cruz de la Sierra flights

Top airline flying from St. Louis to Santa Cruz de la Sierra

Discover the top airline that operate flights from St. Louis to Santa Cruz de la Sierra. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 27, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$653Average$781FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.