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Santa Cruz de la Sierra

$341+ Cheap flights from Santo Domingo (SDQ) to Santa Cruz de la Sierra (VVI)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/21. Fares are subject to change and may not be available on all flights or dates of travel.
SDQ — VVI
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheapflights Tip: The best prices from Santo Domingo Las Americas to Santa Cruz de la Sierra Viru Viru Intl are usually found in April or October, booked 29 days in advance, depart on a Monday or Wednesday and return on a Tuesday

Cheap flight deals from Santo Domingo to Santa Cruz de la Sierra

Discover tips and strategies to find the most affordable flight options for your journey from Santo Domingo (SDQ) to Santa Cruz de la Sierra (VVI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 15, 2025.

Round-trip from

$660
(Gotogate)

One-way from

$341
(Kiwi.com)

Popular in

December

Cheapest in

April

Average price

$665
From Santo Domingo Las Americas to Santa Cruz de la Sierra Viru Viru Intl
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One-way flight from Santo Domingo Las Americas to Santa Cruz de la Sierra Viru Viru Intl
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Highest demand for flights based on searches. 9% potential increase in price ($73 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($24 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Santo Domingo to Santa Cruz de la Sierra

Cheapest flights from Santo Domingo to Santa Cruz de la Sierra
Explore the most affordable flight options available from Santo Domingo to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This Gotogate deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/16:10 pmSDQ - VVI
1 stop7h 40mAvianca
Tue 10/72:50 amVVI - SDQ
1 stop14h 25mAvianca
Deal found 9/12$660
This Copa Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/162:09 pmSDQ - VVI
1 stop13h 27mCopa Airlines
Tue 9/2312:15 pmVVI - SDQ
1 stop10h 11mCopa Airlines
Deal found 9/12$666
This Priceline deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/255:45 pmSDQ - VVI
1 stop8h 50mAvianca
Wed 1/73:40 amVVI - SDQ
1 stop7h 45mAvianca
Deal found 9/13$668
This Copa Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2511:57 amSDQ - VVI
1 stop10h 43mCopa Airlines
Tue 11/2511:40 amVVI - SDQ
1 stop10h 45mCopa Airlines
Deal found 9/12$694
This Copa Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/711:57 amSDQ - VVI
1 stop10h 43mCopa Airlines
Tue 10/1411:59 amVVI - SDQ
1 stop10h 26mCopa Airlines
Deal found 9/13$779
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/259:00 pmSDQ - VVI
1 stop31h 35mMultiple Airlines
Wed 10/82:50 amVVI - SDQ
2 stops18h 55mMultiple Airlines
Deal found 9/13$784
This Mytrip deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/2211:45 amSDQ - VVI
1 stop14h 05mMultiple Airlines
Mon 9/292:50 amVVI - SDQ
2 stops18h 55mMultiple Airlines
Deal found 9/15$797
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/165:41 pmSDQ - VVI
1 stop9h 55mMultiple Airlines
Mon 9/222:50 amVVI - SDQ
2 stops37h 10mMultiple Airlines
Deal found 9/12$803
This Copa Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/156:17 pmSDQ - VVI
1 stop9h 19mCopa Airlines
Sat 9/2012:15 pmVVI - SDQ
1 stop14h 21mCopa Airlines
Deal found 9/15$829
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/14:25 pmSDQ - VVI
1 stop9h 25mMultiple Airlines
Wed 10/85:20 amVVI - SDQ
2 stops17h 20mMultiple Airlines
Deal found 9/12$843

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santo Domingo to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Santo Domingo to Santa Cruz de la Sierra that are best for you.

Fly from

Santo Domingo

Fly to

Santa Cruz de la Sierra

Route

Depart

Return

Price

Santo DomingoSanta Cruz de la Sierra

SDQ - VVI

SDQVVI

Santo Domingo Las Americas

Wed 10/1

6:10 pm-1:50 am

1 stop7h 40m

Santa Cruz de la Sierra Viru Viru Intl

Tue 10/7

2:50 am-5:15 pm

1 stop14h 25m

$660

Santo DomingoSanta Cruz de la Sierra

SDQ - VVI

SDQVVI

Santo Domingo Las Americas

Tue 10/14

2:10 pm-10:40 pm

1 stop8h 30m

Santa Cruz de la Sierra Viru Viru Intl

Tue 10/21

11:59 am-10:25 pm

1 stop10h 26m

$666

Santo DomingoSanta Cruz de la Sierra

SDQ - VVI

SDQVVI

Santo Domingo Las Americas

Thu 9/25

11:45 am-1:50 am

1 stop14h 05m

Santa Cruz de la Sierra Viru Viru Intl

Wed 10/8

2:50 am-5:15 pm

1 stop14h 25m

$666

Santo DomingoSanta Cruz de la Sierra

SDQ - VVI

SDQVVI

Santo Domingo Las Americas

Thu 9/25

11:56 am-10:25 pm

1 stop10h 29m

Santa Cruz de la Sierra Viru Viru Intl

Thu 10/9

11:59 am-10:25 pm

1 stop10h 26m

$666

Santo DomingoSanta Cruz de la Sierra

SDQ - VVI

SDQVVI

Santo Domingo Las Americas

Tue 10/7

6:10 pm-1:50 am

1 stop7h 40m

Santa Cruz de la Sierra Viru Viru Intl

Mon 10/13

2:50 am-5:15 pm

1 stop14h 25m

$666

Santo DomingoSanta Cruz de la Sierra

SDQ - VVI

SDQVVI

Santo Domingo Las Americas

Mon 10/13

11:57 am-3:36 am

1 stop15h 39m

Santa Cruz de la Sierra Viru Viru Intl

Mon 10/20

11:59 am-10:25 pm

1 stop10h 26m

$666

Santo DomingoSanta Cruz de la Sierra

SDQ - VVI

SDQVVI

Santo Domingo Las Americas

Thu 12/25

5:45 pm-2:35 am

1 stop8h 50m

Santa Cruz de la Sierra Viru Viru Intl

Wed 1/7

3:40 am-11:25 am

1 stop7h 45m

$668

Santo DomingoSanta Cruz de la Sierra

SDQ - VVI

SDQVVI

Santo Domingo Las Americas

Sat 10/25

11:57 am-10:40 pm

1 stop10h 43m

Santa Cruz de la Sierra Viru Viru Intl

Tue 11/25

11:40 am-10:25 pm

1 stop10h 45m

$694

Santo DomingoSanta Cruz de la Sierra

SDQ - VVI

SDQVVI

Santo Domingo Las Americas

Sat 1/17

8:50 am-10:50 pm

1 stop14h 00m

Santa Cruz de la Sierra Viru Viru Intl

Sat 1/31

1:15 am-10:50 am

1 stop9h 35m

$696

Santo DomingoSanta Cruz de la Sierra

SDQ - VVI

SDQVVI

Santo Domingo Las Americas

Tue 10/7

11:57 am-10:40 pm

1 stop10h 43m

Santa Cruz de la Sierra Viru Viru Intl

Tue 10/14

11:59 am-10:25 pm

1 stop10h 26m

$779

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Showing 1-10 of 13 results
1
2

Best time to book a flight from Santo Domingo to Santa Cruz de la Sierra

Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Santo Domingo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to Santa Cruz de la Sierra

How far ahead should I book a flight from Santo Domingo to Santa Cruz de la Sierra?

Use this chart to determine the optimal time to book a round-trip flight from Santo Domingo to Santa Cruz de la Sierra. Price data was last updated on September 12, 2025.

The price you pay for your flight from Santo Domingo to Santa Cruz de la Sierra may vary depending on when you book. For the best chance of a lower fare, look to book 28 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Santo Domingo to Santa Cruz de la Sierra?

Currently, October is the cheapest month in which you can book a flight from Santo Domingo to Santa Cruz de la Sierra (average of $597). Flying from Santo Domingo to Santa Cruz de la Sierra in December is currently the most expensive (average of $822). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Santa Cruz de la Sierra

Get insights into the airlines that provide service to Santa Cruz de la Sierra. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Cruz de la Sierra. Reviews last updated September 15, 2025.
See what other customers who have flown with Avianca from Santo Domingo to Santa Cruz de la Sierra have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Avianca
6.7
Okay
2,435 reviews

Entertainment

5.4

Comfort

6.3

Overall

6.7

Crew

7.2

Boarding

7.0

Food

5.1

Reviews

1 / 20
8.0
Excellent

Anonymous,Aug 2025

BOG - LPB

no meals provided. Staff was nice. no entertainment behind seats
Avianca
6.7
Okay
2,435 reviews
Avianca
6.7
Okay
2,435 reviews

Entertainment

5.4

Comfort

6.3

Overall

6.7

Crew

7.2

Boarding

7.0

Food

5.1

Reviews

1 / 20
8.0
Excellent

Anonymous,Aug 2025

BOG - LPB

no meals provided. Staff was nice. no entertainment behind seats

Related info for your journey

Find useful and relevant information for your journey from Santo Domingo to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Santo Domingo to Santa Cruz de la Sierra?

    There are many flights that can get you from Santo Domingo to Santa Cruz de la Sierra in 7h 40m. Fly via Avianca or Copa Airlines to get the fastest option. Santo Domingo and Santa Cruz de la Sierra are separated by a distance of 2530 mi. This flight may include one or multiple stops.

  • What is the cheapest airline to fly from Santo Domingo to Santa Cruz de la Sierra round-trip?

    Avianca, at $505, was found to be the cheapest airline from Santo Domingo to Santa Cruz de la Sierra.. Avianca is 25% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Santo Domingo to Santa Cruz de la Sierra that include hotel bookings?

    Yes. In addition to deals on Santo Domingo to Santa Cruz de la Sierra flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santo Domingo to Santa Cruz de la Sierra?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to Santa Cruz de la Sierra.

  • Can I find deals for business class flights from Santo Domingo to Santa Cruz de la Sierra?

    Yes. Cheapflights offers flight deals from Santo Domingo to Santa Cruz de la Sierra by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santo Domingo to Santa Cruz de la Sierra?

    Currently, October is the cheapest month in which you can book a flight from Santo Domingo to Santa Cruz de la Sierra (average of $597). Flying from Santo Domingo to Santa Cruz de la Sierra in December is currently the most expensive (average of $822). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Complete your trip

Complete your trip to Santa Cruz de la Sierra by adding a car rental and/or hotel reservation to your travel itinerary.
Santa Cruz de la Sierra car rentals
Santa Cruz de la Sierra Viru Viru Intl Airport car rentals
La Paz car rentals
Cochabamba car rentals
Tarija car rentals

Top airline flying from Santo Domingo to Santa Cruz de la Sierra

Discover the top airline that operate flights from Santo Domingo to Santa Cruz de la Sierra. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$505Average$611FlexibilityNo cancel feeOn-time71%

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