$319+ Cheap flights from Santo Domingo (SDQ) to Santa Cruz de la Sierra (VVI)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/17. Fares are subject to change and may not be available on all flights or dates of travel.
SDQ — VVI
mar. 4 — mar. 111
1 adult, Economy
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Find cheap flights from Santo Domingo to Santa Cruz de la Sierra with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Santo Domingo to Santa Cruz de la Sierra
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Cheapest flights from Santo Domingo to Santa Cruz de la SierraExplore the most affordable flight options available from Santo Domingo to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on febrero 2, 2026.
Explore the most affordable flight options available from Santo Domingo to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on febrero 2, 2026.
This Copa Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 5/48:45 am
SDQ
- VVI
1 stop13h 53m
Copa Airlines
dom. 5/171:12 am
VVI
- SDQ
1 stop9h 43m
Copa Airlines
Deal found 1/31![Copa Airlines logo]()
$716
This Copa Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 10/62:16 pm
SDQ
- VVI
1 stop8h 28m
Copa Airlines
sáb. 10/101:12 am
VVI
- SDQ
1 stop10h 29m
Copa Airlines
Deal found 1/30![Copa Airlines logo]()
$743
This Copa Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 7/128:48 am
SDQ
- VVI
1 stop13h 52m
Copa Airlines
sáb. 7/181:12 am
VVI
- SDQ
1 stop10h 30m
Copa Airlines
Deal found 1/31![Copa Airlines logo]()
$794
This FlightHub deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 6/812:45 pm
SDQ
- VVI
1 stop13h 45m
Avianca
jue. 6/113:35 am
VVI
- SDQ
1 stop14h 20m
Avianca
Deal found 2/2![Avianca logo]()
$826
This Avianca deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 6/66:50 pm
SDQ
- VVI
1 stop7h 40m
Avianca
jue. 6/113:35 am
VVI
- SDQ
1 stop14h 20m
Avianca
Deal found 2/2![Avianca logo]()
$838
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 6/1012:45 pm
SDQ
- VVI
2 stops15h 50m
Multiple Airlines
vie. 6/129:30 pm
VVI
- SDQ
1 stop16h 15m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$955
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 6/712:45 pm
SDQ
- VVI
2 stops15h 50m
Multiple Airlines
vie. 6/129:30 pm
VVI
- SDQ
1 stop16h 15m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$958
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 6/612:45 pm
SDQ
- VVI
1 stop13h 45m
Multiple Airlines
vie. 6/125:25 am
VVI
- SDQ
2 stops21h 38m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$1,051
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 6/810:19 am
SDQ
- VVI
2 stops17h 12m
Multiple Airlines
vie. 6/129:30 pm
VVI
- SDQ
1 stop16h 15m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$1,052
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 6/117:40 am
SDQ
- VVI
1 stop18h 50m
Multiple Airlines
vie. 6/129:30 pm
VVI
- SDQ
1 stop16h 15m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$1,099
This Copa Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 2/311:57 am
SDQ
- VVI
1 stop10h 53m
Copa Airlines
vie. 2/61:15 am
VVI
- SDQ
1 stop9h 35m
Copa Airlines
Deal found 1/30![Copa Airlines logo]()
$1,110
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 6/97:40 am
SDQ
- VVI
2 stops14h 58m
Multiple Airlines
vie. 6/129:30 pm
VVI
- SDQ
1 stop16h 15m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$1,137
Best flights from Santo Domingo to Santa Cruz de la SierraDiscover carefully curated flight deals from Santo Domingo to Santa Cruz de la Sierra that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated febrero 2, 2026.
Discover carefully curated flight deals from Santo Domingo to Santa Cruz de la Sierra that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated febrero 2, 2026.
This Copa Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 6/98:45 am
SDQ
- VVI
1 stop13h 53m
Copa Airlines
jue. 6/111:12 am
VVI
- SDQ
1 stop12h 01m
Copa Airlines
Deal found 2/2![Copa Airlines logo]()
$716
This FlightHub deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 6/812:45 pm
SDQ
- VVI
1 stop13h 45m
Avianca
jue. 6/113:35 am
VVI
- SDQ
1 stop14h 20m
Avianca
Deal found 2/2![Avianca logo]()
$826
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 6/1012:45 pm
SDQ
- VVI
2 stops15h 50m
Multiple Airlines
vie. 6/129:30 pm
VVI
- SDQ
1 stop16h 15m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$955
This Copa Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 6/218:45 am
SDQ
- VVI
1 stop13h 53m
Copa Airlines
mar. 8/41:12 am
VVI
- SDQ
1 stop15h 03m
Copa Airlines
Deal found 1/31![Copa Airlines logo]()
$716
This Copa Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 5/48:45 am
SDQ
- VVI
1 stop13h 53m
Copa Airlines
dom. 5/171:12 am
VVI
- SDQ
1 stop9h 43m
Copa Airlines
Deal found 1/31![Copa Airlines logo]()
$716
This FlightHub deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 6/106:50 pm
SDQ
- VVI
1 stop7h 40m
Avianca
jue. 6/113:35 am
VVI
- SDQ
1 stop14h 20m
Avianca
Deal found 2/2![Avianca logo]()
$826
This Avianca deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 6/66:50 pm
SDQ
- VVI
1 stop7h 40m
Avianca
jue. 6/113:35 am
VVI
- SDQ
1 stop14h 20m
Avianca
Deal found 2/2![Avianca logo]()
$838
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 6/712:45 pm
SDQ
- VVI
2 stops15h 50m
Multiple Airlines
vie. 6/129:30 pm
VVI
- SDQ
1 stop16h 15m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$958
This Copa Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 7/128:48 am
SDQ
- VVI
1 stop13h 52m
Copa Airlines
sáb. 7/181:12 am
VVI
- SDQ
1 stop10h 30m
Copa Airlines
Deal found 1/31![Copa Airlines logo]()
$794
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 6/612:45 pm
SDQ
- VVI
1 stop13h 45m
Multiple Airlines
vie. 6/125:25 am
VVI
- SDQ
2 stops21h 38m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$1,051
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 6/810:19 am
SDQ
- VVI
2 stops17h 12m
Multiple Airlines
vie. 6/129:30 pm
VVI
- SDQ
1 stop16h 15m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$1,052
Last-minute flights from Santo Domingo to Santa Cruz de la SierraDiscover last-minute flight deals from Santo Domingo to Santa Cruz de la Sierra. Data last updated febrero 2, 2026 and is based on user searches.
Discover last-minute flight deals from Santo Domingo to Santa Cruz de la Sierra. Data last updated febrero 2, 2026 and is based on user searches.
This Copa Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 2/311:57 am
SDQ
- VVI
1 stop10h 53m
Copa Airlines
vie. 2/61:15 am
VVI
- SDQ
1 stop9h 35m
Copa Airlines
Deal found 1/30![Copa Airlines logo]()
$1,110
This FlightHub deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 2/35:45 pm
SDQ
- VVI
1 stop8h 50m
Multiple Airlines
vie. 2/63:40 am
VVI
- SDQ
2 stops16h 04m
Multiple Airlines
Deal found 1/30![Multiple Airlines logo]()
$1,863
One-way flights from Santo Domingo to Santa Cruz de la SierraSearch for one-way flight options from Santo Domingo to Santa Cruz de la Sierra. Find affordable one-way fares based on user searches. Data last updated febrero 2, 2026.
Search for one-way flight options from Santo Domingo to Santa Cruz de la Sierra. Find affordable one-way fares based on user searches. Data last updated febrero 2, 2026.
This Avianca deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 3/175:45 pm
SDQ
- VVI
1 stop8h 50m
Avianca
Deal found 1/31![Avianca logo]()
$319
This Kiwi.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 3/176:41 pm
SDQ
- VVI
3 stops31h 54m
Multiple Airlines
Deal found 1/31![Multiple Airlines logo]()
$360
Find flight deals from Santo Domingo to Santa Cruz de la Sierra
Discover tips and strategies to find the most affordable flight options for your journey from Santo Domingo (SDQ) to Santa Cruz de la Sierra (VVI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated febrero 2, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $716 (Copa Airlines) |
One-way from | $319 (Avianca) |
Popular in | May |
Cheapest in | April |
Average price | $637 |
Cheapflights Fare Finder
Customize your flight search to find flights from Santo Domingo to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated febrero 2, 2026.
Use the filters below to find and compare flights from Santo Domingo to Santa Cruz de la Sierra that are best for you.
Fly from
Santo Domingo
Fly to
Santa Cruz de la Sierra
Route
Depart
Return
Price
Santo DomingoSanta Cruz de la Sierra
SDQ - VVI
SDQVVI
Santo Domingo Las Americas
mar. 6/9
8:45 am-10:38 pm
1 stop13h 53m
Santa Cruz de la Sierra Viru Viru Intl
jue. 6/11
1:12 am-1:13 pm
1 stop12h 01m
$716
Santo DomingoSanta Cruz de la Sierra
SDQ - VVI
SDQVVI
Santo Domingo Las Americas
dom. 6/21
8:45 am-10:38 pm
1 stop13h 53m
Santa Cruz de la Sierra Viru Viru Intl
mar. 8/4
1:12 am-4:15 pm
1 stop15h 03m
$716
Santo DomingoSanta Cruz de la Sierra
SDQ - VVI
SDQVVI
Santo Domingo Las Americas
lun. 5/4
8:45 am-10:38 pm
1 stop13h 53m
Santa Cruz de la Sierra Viru Viru Intl
dom. 5/17
1:12 am-10:55 am
1 stop9h 43m
$716
Santo DomingoSanta Cruz de la Sierra
SDQ - VVI
SDQVVI
Santo Domingo Las Americas
dom. 7/12
8:48 am-10:40 pm
1 stop13h 52m
Santa Cruz de la Sierra Viru Viru Intl
sáb. 7/18
1:12 am-11:42 am
1 stop10h 30m
$794
Santo DomingoSanta Cruz de la Sierra
SDQ - VVI
SDQVVI
Santo Domingo Las Americas
lun. 6/8
12:45 pm-2:30 am
1 stop13h 45m
Santa Cruz de la Sierra Viru Viru Intl
jue. 6/11
3:35 am-5:55 pm
1 stop14h 20m
$826
Santo DomingoSanta Cruz de la Sierra
SDQ - VVI
SDQVVI
Santo Domingo Las Americas
mié. 6/10
6:50 pm-2:30 am
1 stop7h 40m
Santa Cruz de la Sierra Viru Viru Intl
jue. 6/11
3:35 am-5:55 pm
1 stop14h 20m
$826
Santo DomingoSanta Cruz de la Sierra
SDQ - VVI
SDQVVI
Santo Domingo Las Americas
sáb. 6/6
6:50 pm-2:30 am
1 stop7h 40m
Santa Cruz de la Sierra Viru Viru Intl
jue. 6/11
3:35 am-5:55 pm
1 stop14h 20m
$838
Santo DomingoSanta Cruz de la Sierra
SDQ - VVI
SDQVVI
Santo Domingo Las Americas
mié. 6/10
12:45 pm-4:35 am
2 stops15h 50m
Santa Cruz de la Sierra Viru Viru Intl
vie. 6/12
9:30 pm-1:45 pm
1 stop16h 15m
$955
Santo DomingoSanta Cruz de la Sierra
SDQ - VVI
SDQVVI
Santo Domingo Las Americas
dom. 6/7
12:45 pm-4:35 am
2 stops15h 50m
Santa Cruz de la Sierra Viru Viru Intl
vie. 6/12
9:30 pm-1:45 pm
1 stop16h 15m
$958
Santo DomingoSanta Cruz de la Sierra
SDQ - VVI
SDQVVI
Santo Domingo Las Americas
sáb. 6/6
12:45 pm-2:30 am
1 stop13h 45m
Santa Cruz de la Sierra Viru Viru Intl
vie. 6/12
5:25 am-3:03 am
2 stops21h 38m
$1,051
Showing 1-10 of 13 results
- Most accurate provider: When it comes to deals on Santo Domingo-Santa Cruz de la Sierra flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santo Domingo-Santa Cruz de la Sierra flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santo Domingo-Santa Cruz de la Sierra flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Santo Domingo-Santa Cruz de la Sierra flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santo Domingo-Santa Cruz de la Sierra flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Santo Domingo to Santa Cruz de la Sierra
Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Santo Domingo with our price prediction graph.
SDQ-VVI
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Santo Domingo to Santa Cruz de la Sierra
How far ahead should I book a flight from Santo Domingo to Santa Cruz de la Sierra?
Use this chart to determine the optimal time to book a round-trip flight from Santo Domingo to Santa Cruz de la Sierra. Price data was last updated on January 30, 2026.
The price you pay for your flight from Santo Domingo to Santa Cruz de la Sierra may vary depending on when you book. For the best chance of a lower fare, look to book 28 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Santo Domingo to Santa Cruz de la Sierra?
Currently, April is the cheapest month in which you can book a flight from Santo Domingo to Santa Cruz de la Sierra (average of $293). Flying from Santo Domingo to Santa Cruz de la Sierra in August is currently the most expensive (average of $665). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Santo Domingo to Santa Cruz de la Sierra?
Reviews of airlines servicing Santa Cruz de la Sierra
Get insights into the airlines that provide service to Santa Cruz de la Sierra. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Cruz de la Sierra. Reviews last updated febrero 2, 2026.
See what other customers who have flown with Avianca from Santo Domingo to Santa Cruz de la Sierra have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
6.5
Entertainment
5.4
Boarding
6.9
Food
5.0
Comfort
6.2
Crew
7.2
Reviews
1 / 20
8.0
ExcellentAnonymous,Aug 2025
BOG - LPB
Overall
6.5
Entertainment
5.4
Boarding
6.9
Food
5.0
Comfort
6.2
Crew
7.2
Reviews
1 / 20
8.0
ExcellentAnonymous,Aug 2025
BOG - LPB
Related info for your journey
Find useful and relevant information for your journey from Santo Domingo to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Complete your trip
Complete your trip to Santa Cruz de la Sierra by adding a car rental and/or hotel reservation to your travel itinerary.
Top airline flying from Santo Domingo to Santa Cruz de la Sierra
Discover the top airline that operate flights from Santo Domingo to Santa Cruz de la Sierra. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated febrero 2, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$284 | Average$737 | FlexibilityNo cancel fee | On-time71% |