What are the cheapest airlines to fly from San Francisco to Santa Cruz de la Sierra one-way?

To fly one-way, consider booking your trip with United Airlines, which is currently one of the cheapest options available, starting at $305. Copa Airlines flights start at $345 while deals on Avianca start at $408 one-way.

What is the cheapest day to fly from San Francisco to Santa Cruz de la Sierra?

Travelers seeking maximum savings on their San Francisco to Santa Cruz de la Sierra flight should consider departing on Saturday at noon when fares are most often at their lowest. Sunday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

What are the most popular airlines that fly from San Francisco to Santa Cruz de la Sierra?

Avianca, Copa Airlines and United Airlines are the most popular airlines when flying from San Francisco to Santa Cruz de la Sierra.

What is the cheapest day to fly round-trip from San Francisco to Santa Cruz de la Sierra?

Saturday flights are generally found to be more expensive for flights from San Francisco to Santa Cruz de la Sierra. This shouldn’t discourage you from searching, as you can still find great deals by being flexible with your options. Use our search form to find deals on tickets to Santa Cruz de la Sierra.

What is the cheapest month to fly from San Francisco to Santa Cruz de la Sierra?

Due to multiple factors, expect to potentially pay more when booking in December. For low rates, March can be a great choice for travel to Santa Cruz de la Sierra. Flights to Santa Cruz de la Sierra from San Francisco in March are about $950 on average during March, but can be found for as low as $585.

How can I find direct flights from San Francisco to Santa Cruz de la Sierra?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Francisco to Santa Cruz de la Sierra.

Can I find deals for business class flights from San Francisco to Santa Cruz de la Sierra?

Yes. Cheapflights offers flight deals from San Francisco to Santa Cruz de la Sierra by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$305+ Flights from San Francisco to Santa Cruz de la Sierra

Q: How far in advance should I book a flight from San Francisco to Santa Cruz de la Sierra?

To save up to 31% on this flight, we recommend booking at least 58 days prior to travel. The price may fluctuate and will likely increase closer to your departure date. Users on Cheapflights have found tickets from San Francisco to Santa Cruz de la Sierra from $656 1-2 weeks out and tickets from $903 for flights departing within the next 72 hours.

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Find cheap flights from San Francisco to Santa Cruz de la Sierra with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

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3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from San Francisco to Santa Cruz de la Sierra Viru Viru Intl are usually found in March or October, booked 68 days in advance, depart on a Friday or Saturday and return on a Tuesday

Cheap flight deals from San Francisco to Santa Cruz de la Sierra

Round-trip from	$623 (United Airlines)
One-way from	$305 (United Airlines)
Popular in	December
Cheapest in	March
Average price	$1,097

From San Francisco to Santa Cruz de la Sierra Viru Viru Intl

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One-way flight from San Francisco to Santa Cruz de la Sierra Viru Viru Intl

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Highest demand for flights based on searches. 19% potential increase in price ($232 potential increase over avg. RT price).

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Cheapest flight prices on average. 7% potential price decrease ($65 potential savings vs. average RT price).

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Average for round-trip flights in June 2025

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Find flight deals from San Francisco to Santa Cruz de la Sierra

Cheapest flights from San Francisco to Santa Cruz de la Sierra
Explore the most affordable flight options available from San Francisco to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on junio 12, 2025.

sáb. 8/99:15 pmSFO - VVI

2 stops22h 04mUnited Airlines

mié. 8/131:09 amVVI - SFO

1 stop23h 06mUnited Airlines

Deal found 6/12

$623

sáb. 10/410:55 amSFO - VVI

1 stop32h 22mMultiple Airlines

vie. 10/172:55 amVVI - SFO

2 stops19h 00mMultiple Airlines

Deal found 6/10

$632

mar. 7/812:05 amSFO - VVI

2 stops22h 45mAvianca

mar. 7/152:55 amVVI - SFO

2 stops22h 50mAvianca

Deal found 6/11

$863

mié. 7/21:25 amSFO - VVI

1 stop17h 54mCopa Airlines

lun. 7/712:15 pmVVI - SFO

1 stop14h 25mCopa Airlines

Deal found 6/11

$991

dom. 10/126:00 amSFO - VVI

2 stops19h 35mLATAM Airlines

dom. 10/2610:16 amVVI - SFO

2 stops31h 53mLATAM Airlines

Deal found 6/11

$1,069

lun. 8/1112:15 pmSFO - VVI

2 stops43h 50mGOL

vie. 8/2212:00 pmVVI - SFO

2 stops25h 11mGOL

Deal found 6/11

$10,038

Best flights from San Francisco to Santa Cruz de la Sierra
Discover carefully curated flight deals from San Francisco to Santa Cruz de la Sierra that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated junio 12, 2025.

sáb. 8/99:15 pmSFO - VVI

2 stops22h 04mUnited Airlines

mié. 8/131:09 amVVI - SFO

1 stop23h 06mUnited Airlines

Deal found 6/12

$623

sáb. 10/410:55 amSFO - VVI

1 stop32h 22mMultiple Airlines

vie. 10/172:55 amVVI - SFO

2 stops19h 00mMultiple Airlines

Deal found 6/10

$632

mar. 7/812:05 amSFO - VVI

2 stops22h 45mAvianca

mar. 7/152:55 amVVI - SFO

2 stops22h 50mAvianca

Deal found 6/11

$863

mié. 7/21:25 amSFO - VVI

1 stop17h 54mCopa Airlines

lun. 7/712:15 pmVVI - SFO

1 stop14h 25mCopa Airlines

Deal found 6/11

$991

dom. 10/126:00 amSFO - VVI

2 stops19h 35mLATAM Airlines

dom. 10/2610:16 amVVI - SFO

2 stops31h 53mLATAM Airlines

Deal found 6/12

$1,069

Last-minute flights from San Francisco to Santa Cruz de la Sierra
Discover last-minute flight deals from San Francisco to Santa Cruz de la Sierra. Data last updated junio 12, 2025 and is based on user searches.

jue. 6/191:37 amSFO - VVI

1 stop22h 57mCopa Airlines

jue. 7/1012:15 pmVVI - SFO

1 stop14h 25mCopa Airlines

Deal found 6/11

$1,002

vie. 6/2010:55 amSFO - VVI

1 stop32h 18mMultiple Airlines

mié. 7/92:55 amVVI - SFO

2 stops24h 04mMultiple Airlines

Deal found 6/11

$765

vie. 6/2011:59 pmSFO - VVI

3 stops25h 36mLATAM Airlines

jue. 7/105:20 amVVI - SFO

3 stops22h 20mLATAM Airlines

Deal found 6/11

$1,289

mié. 7/21:25 amSFO - VVI

1 stop17h 54mCopa Airlines

lun. 7/712:15 pmVVI - SFO

1 stop14h 25mCopa Airlines

Deal found 6/11

$991

mar. 7/812:05 amSFO - VVI

2 stops22h 45mAvianca

mar. 7/152:55 amVVI - SFO

2 stops22h 50mAvianca

Deal found 6/11

$863

mié. 7/98:55 amSFO - VVI

2 stops40h 40mLATAM Airlines

mié. 7/168:26 amVVI - SFO

2 stops33h 24mLATAM Airlines

Deal found 6/11

$1,090

lun. 7/2812:20 amSFO - VVI

2 stops18h 59mUnited Airlines

lun. 9/11:09 amVVI - SFO

1 stop23h 01mUnited Airlines

Deal found 6/11

$917

One-way flights from San Francisco to Santa Cruz de la Sierra
Search for one-way flight options from San Francisco to Santa Cruz de la Sierra. Find affordable one-way fares based on user searches. Data last updated junio 12, 2025.

vie. 9/2610:55 amSFO - VVI

1 stop32h 30mUnited Airlines

Deal found 6/10

$305

sáb. 7/191:25 amSFO - VVI

1 stop23h 14mCopa Airlines

Deal found 6/11

$345

jue. 9/252:30 amSFO - VVI

2 stops20h 20mAvianca

Deal found 6/12

$408

dom. 7/202:20 pmSFO - VVI

3 stops35h 15mMultiple Airlines

Deal found 6/11

$495

Cheapflights Fare Finder

Use the filters below to find and compare flights from San Francisco to Santa Cruz de la Sierra that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San FranciscoSanta Cruz de la Sierra

SFO - VVI

SFOVVI

San Francisco

sáb. 8/9

12:30 am-10:19 pm

2 stops18h 49m

Santa Cruz de la Sierra Viru Viru Intl

jue. 8/14

1:09 am-9:15 pm

1 stop23h 06m

$623

San FranciscoSanta Cruz de la Sierra

SFO - VVI

SFOVVI

San Francisco

sáb. 10/4

10:55 am-10:17 pm

1 stop32h 22m

Santa Cruz de la Sierra Viru Viru Intl

vie. 10/17

2:55 am-6:55 pm

2 stops19h 00m

$632

San FranciscoSanta Cruz de la Sierra

SFO - VVI

SFOVVI

San Francisco

mar. 7/8

12:05 am-1:50 am

2 stops22h 45m

Santa Cruz de la Sierra Viru Viru Intl

mar. 7/15

2:55 am-10:45 pm

2 stops22h 50m

$863

San FranciscoSanta Cruz de la Sierra

SFO - VVI

SFOVVI

San Francisco

mié. 7/2

1:25 am-10:19 pm

1 stop17h 54m

Santa Cruz de la Sierra Viru Viru Intl

lun. 7/7

12:15 pm-11:40 pm

1 stop14h 25m

$991

San FranciscoSanta Cruz de la Sierra

SFO - VVI

SFOVVI

San Francisco

dom. 10/12

6:00 am-4:35 am

2 stops19h 35m

Santa Cruz de la Sierra Viru Viru Intl

dom. 10/26

10:16 am-3:09 pm

2 stops31h 53m

$1,069

San FranciscoSanta Cruz de la Sierra

SFO - VVI

SFOVVI

San Francisco

lun. 8/11

12:15 pm-11:05 am

2 stops43h 50m

Santa Cruz de la Sierra Viru Viru Intl

vie. 8/22

12:00 pm-10:11 am

2 stops25h 11m

$10,038

San FranciscoSanta Cruz de la Sierra

SFO - VVI

SFOVVI

San Francisco

vie. 9/26

10:55 am-10:25 pm

1 stop32h 30m

$305

San FranciscoSanta Cruz de la Sierra

SFO - VVI

SFOVVI

San Francisco

sáb. 7/19

1:25 am-3:39 am

1 stop23h 14m

$345

San FranciscoSanta Cruz de la Sierra

SFO - VVI

SFOVVI

San Francisco

jue. 9/25

2:30 am-1:50 am

2 stops20h 20m

$408

San FranciscoSanta Cruz de la Sierra

SFO - VVI

SFOVVI

San Francisco

dom. 7/20

2:20 pm-4:35 am

3 stops35h 15m

$495

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/10

Best time to book a flight from San Francisco to Santa Cruz de la Sierra

Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from San Francisco with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Francisco to Santa Cruz de la Sierra

How far ahead should I book a flight from San Francisco to Santa Cruz de la Sierra?

Booking 68 days in advance of your planned departure date is, on average, the best time to get cheap flights from San Francisco to Santa Cruz de la Sierra. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from San Francisco to Santa Cruz de la Sierra?

Currently, October is the cheapest month in which you can book a flight from San Francisco to Santa Cruz de la Sierra (average of $597). Flying from San Francisco to Santa Cruz de la Sierra in December is currently the most expensive (average of $822). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SFO to VVI?

It’s optimal to fly from San Francisco to Santa Cruz de la Sierra at noon. By choosing this option you can save up to 26% on the cost of your flight, compared to a flight in the afternoon.

Reviews of airlines servicing Santa Cruz de la Sierra

Read reviews from past customers who have flown LATAM Airlines, Copa Airlines and United Airlines from San Francisco to Santa Cruz de la Sierra. In addition to providing an overall rating, users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

LATAM Airlines

7.5

Good

1,785 reviews

Reviews

1 / 20

6.0

Good

Anonymous,Mar 2025

MCO - BOG

The problem was the delayed departure for airport reason I understood it was not a Latam responsibility. The crew could give something to drink and not only a candy.

LATAM Airlines

7.5

Good

1,785 reviews

LATAM Airlines

7.5

Good

1,785 reviews

Reviews

1 / 20

6.0

Good

Anonymous,Mar 2025

MCO - BOG

The problem was the delayed departure for airport reason I understood it was not a Latam responsibility. The crew could give something to drink and not only a candy.

Copa Airlines

7.5

Good

1,451 reviews

LATAM Airlines

7.5

Good

1,785 reviews

Reviews

1 / 20

6.0

Good

Anonymous,Mar 2025

MCO - BOG

The problem was the delayed departure for airport reason I understood it was not a Latam responsibility. The crew could give something to drink and not only a candy.

United Airlines

7.4

Good

8,790 reviews

LATAM Airlines

7.5

Good

1,785 reviews

Reviews

1 / 20

6.0

Good

Anonymous,Mar 2025

MCO - BOG

The problem was the delayed departure for airport reason I understood it was not a Latam responsibility. The crew could give something to drink and not only a candy.

Avianca

6.7

Okay

2,345 reviews

LATAM Airlines

7.5

Good

1,785 reviews

Reviews

1 / 20

6.0

Good

Anonymous,Mar 2025

MCO - BOG

The problem was the delayed departure for airport reason I understood it was not a Latam responsibility. The crew could give something to drink and not only a candy.

Related info for your journey

What are the cheapest airlines flying from San Francisco to Santa Cruz de la Sierra round-trip?
Cheapflights users have booked flights from San Francisco to Santa Cruz de la Sierra round-trip from $623. Other airlines that can offer you cheap pricing are Avianca, from $863, and Copa Airlines, from $991. United Airlines is priced at 34% lower than the current average price of a flight leaving 3 months from now.
What are the cheapest airlines to fly from San Francisco to Santa Cruz de la Sierra one-way?
To fly one-way, consider booking your trip with United Airlines, which is currently one of the cheapest options available, starting at $305. Copa Airlines flights start at $345 while deals on Avianca start at $408 one-way.
Can I find deals for flights from San Francisco to Santa Cruz de la Sierra that include hotel bookings?
Yes. In addition to deals on San Francisco to Santa Cruz de la Sierra flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from San Francisco to Santa Cruz de la Sierra?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Francisco to Santa Cruz de la Sierra.
Can I find deals for business class flights from San Francisco to Santa Cruz de la Sierra?
Yes. Cheapflights offers flight deals from San Francisco to Santa Cruz de la Sierra by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from San Francisco to Santa Cruz de la Sierra?
Currently, October is the cheapest month in which you can book a flight from San Francisco to Santa Cruz de la Sierra (average of $597). Flying from San Francisco to Santa Cruz de la Sierra in December is currently the most expensive (average of $822). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Alternative routes for San Francisco to Santa Cruz de la Sierra

Top 3 airlines flying from San Francisco to Santa Cruz de la Sierra

Airline	Cheapest	Average	Flexibility	On-time
Avianca	Cheapest$585	Average$920	FlexibilityNo cancel fee	On-time71%
United Airlines	Cheapest$589	Average$822	FlexibilityNo cancel fee	On-time69%
Copa Airlines	Cheapest$608	Average$967	FlexibilityNo cancel fee	On-time70%

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$305+ Cheap flights from San Francisco (SFO) to Santa Cruz de la Sierra (VVI)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/26. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from San Francisco to Santa Cruz de la Sierra with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from San Francisco to Santa Cruz de la Sierra Viru Viru Intl are usually found in March or October, booked 68 days in advance, depart on a Friday or Saturday and return on a Tuesday

Cheap flight deals from San Francisco to Santa Cruz de la Sierra

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from San Francisco to Santa Cruz de la Sierra

Cheapest flights from San Francisco to Santa Cruz de la SierraExplore the most affordable flight options available from San Francisco to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on junio 12, 2025.

Explore the most affordable flight options available from San Francisco to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on junio 12, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from San Francisco to Santa Cruz de la Sierra that are best for you.

Best time to book a flight from San Francisco to Santa Cruz de la Sierra

Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from San Francisco with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from San Francisco to Santa Cruz de la Sierra

How far ahead should I book a flight from San Francisco to Santa Cruz de la Sierra?

Use this chart to determine the optimal time to book a round-trip flight from San Francisco to Santa Cruz de la Sierra. Price data was last updated on June 9, 2025.

What is the cheapest month to book a flight from San Francisco to Santa Cruz de la Sierra?

What is the cheapest time of day to fly from SFO to VVI?

Find hourly flight availability from San Francisco to Santa Cruz de la Sierra. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated junio 12, 2025.

Reviews of airlines servicing Santa Cruz de la Sierra

Related info for your journey

Find useful and relevant information for your journey from San Francisco to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from San Francisco to Santa Cruz de la Sierra round-trip?

What are the cheapest airlines to fly from San Francisco to Santa Cruz de la Sierra one-way?

Can I find deals for flights from San Francisco to Santa Cruz de la Sierra that include hotel bookings?

How can I find direct flights from San Francisco to Santa Cruz de la Sierra?

Can I find deals for business class flights from San Francisco to Santa Cruz de la Sierra?

What is the cheapest month to book a flight from San Francisco to Santa Cruz de la Sierra?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for San Francisco to Santa Cruz de la Sierra

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from San Francisco to Santa Cruz de la Sierra

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Cheapest flights from San Francisco to Santa Cruz de la Sierra
Explore the most affordable flight options available from San Francisco to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on junio 12, 2025.