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Santa Cruz de la Sierra

$327+ Cheap flights from San Francisco (SFO) to Santa Cruz de la Sierra (VVI)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/18. Fares are subject to change and may not be available on all flights or dates of travel.
SFO — VVI
Apr 13 — Apr 201
Mon 4/13
Mon 4/20
1 adult, Economy
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Find cheap flights from San Francisco to Santa Cruz de la Sierra with Cheapflights

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Cheap flight deals from San Francisco to Santa Cruz de la Sierra

Cheapest flights from San Francisco to Santa Cruz de la Sierra
Explore the most affordable flight options available from San Francisco to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 14, 2026.

This Trip.com deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/116:43 pm
SFO
-
VVI
3 stops28h 47m
Multiple Airlines
Sun 4/193:35 am
VVI
-
SFO
3 stops45h 04m
Multiple Airlines
Deal found 3/9$668
This Copa Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/71:23 am
SFO
-
VVI
1 stop18h 19m
Copa Airlines
Wed 4/221:15 am
VVI
-
SFO
1 stop20h 10m
Copa Airlines
Deal found 3/10$694
This Copa Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/121:23 am
SFO
-
VVI
1 stop18h 19m
Copa Airlines
Tue 4/211:15 am
VVI
-
SFO
1 stop20h 10m
Copa Airlines
Deal found 3/9$714
This Copa Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/71:23 am
SFO
-
VVI
1 stop18h 19m
Copa Airlines
Tue 4/211:15 am
VVI
-
SFO
1 stop20h 10m
Copa Airlines
Deal found 3/9$734
This Justfly.com deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/72:30 am
SFO
-
VVI
2 stops21h 00m
Avianca
Tue 4/213:35 am
VVI
-
SFO
2 stops22h 00m
Avianca
Deal found 3/9$738
This United Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/712:45 am
SFO
-
VVI
2 stops18h 57m
United Airlines
Thu 4/2311:48 am
VVI
-
SFO
2 stops24h 01m
United Airlines
Deal found 3/10$749
This United Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/227:00 am
SFO
-
VVI
2 stops36h 50m
United Airlines
Tue 3/3111:58 am
VVI
-
SFO
2 stops46h 18m
United Airlines
Deal found 3/9$756
This Mytrip deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/201:23 am
SFO
-
VVI
1 stop18h 19m
Copa Airlines
Tue 5/1911:47 am
VVI
-
SFO
1 stop33h 27m
Copa Airlines
Deal found 3/10$771
This Gotogate deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/238:37 pm
SFO
-
VVI
1 stop23h 05m
Copa Airlines
Wed 5/201:12 am
VVI
-
SFO
1 stop20h 02m
Copa Airlines
Deal found 3/10$772

Find flight deals from San Francisco to Santa Cruz de la Sierra

Discover tips and strategies to find the most affordable flight options for your journey from San Francisco (SFO) to Santa Cruz de la Sierra (VVI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 14, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$668
(Trip.com)

One-way from

$327
(Kiwi.com)

Popular in

December

Cheapest in

March

Average price

$356
Provider with most accurate pricing for San Francisco-Santa Cruz de la Sierra Viru Viru Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for San Francisco-Santa Cruz de la Sierra Viru Viru Intl flights.
Search Deals
From San Francisco to Santa Cruz de la Sierra Viru Viru Intl
Search Deals
One-way flight from San Francisco to Santa Cruz de la Sierra Viru Viru Intl
Search Deals
Highest demand for flights based on searches. 22% potential increase in price ($250 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 8% potential price decrease ($72 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from San Francisco to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 14, 2026.
Use the filters below to find and compare flights from San Francisco to Santa Cruz de la Sierra that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

San FranciscoSanta Cruz de la Sierra

SFO - VVI

SFOVVI

San Francisco

Sun 4/12

1:23 am-10:42 pm

1 stop18h 19m

Santa Cruz de la Sierra Viru Viru Intl

Tue 4/21

1:15 am-6:25 pm

1 stop20h 10m

$714

San FranciscoSanta Cruz de la Sierra

SFO - VVI

SFOVVI

San Francisco

Tue 4/7

1:23 am-10:42 pm

1 stop18h 19m

Santa Cruz de la Sierra Viru Viru Intl

Tue 4/21

1:15 am-6:25 pm

1 stop20h 10m

$724

San FranciscoSanta Cruz de la Sierra

SFO - VVI

SFOVVI

San Francisco

Mon 4/13

12:45 am-10:42 pm

2 stops18h 57m

Santa Cruz de la Sierra Viru Viru Intl

Tue 4/21

11:48 am-6:58 pm

2 stops34h 10m

$749

San FranciscoSanta Cruz de la Sierra

SFO - VVI

SFOVVI

San Francisco

Sun 8/30

1:12 am-10:40 pm

1 stop18h 28m

Santa Cruz de la Sierra Viru Viru Intl

Wed 9/30

1:12 am-6:10 pm

1 stop19h 58m

$754
Quickest round-trip

San FranciscoSanta Cruz de la Sierra

SFO - VVI

SFOVVI

San Francisco

Tue 4/7

1:23 am-10:42 pm

1 stop18h 19m

Santa Cruz de la Sierra Viru Viru Intl

Thu 4/23

11:48 am-11:40 pm

1 stop14h 52m

$754
Cheapest one-way

San FranciscoSanta Cruz de la Sierra

SFO - VVI

SFOVVI

San Francisco

Sat 4/18

6:00 am-10:42 pm

3 stops37h 42m

$327

San FranciscoSanta Cruz de la Sierra

SFO - VVI

SFOVVI

San Francisco

Sat 5/30

6:54 pm-10:38 pm

2 stops24h 44m

$355

San FranciscoSanta Cruz de la Sierra

SFO - VVI

SFOVVI

San Francisco

Sat 4/18

6:55 pm-3:40 am

2 stops29h 45m

$355

San FranciscoSanta Cruz de la Sierra

SFO - VVI

SFOVVI

San Francisco

Fri 5/29

1:12 am-10:38 pm

1 stop18h 26m

$370
Quickest one-way

San FranciscoSanta Cruz de la Sierra

SFO - VVI

SFOVVI

San Francisco

Fri 4/17

1:23 am-10:42 pm

1 stop18h 19m

$370

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/9

Showing 1-10 of 13 resultsSorted by cheapest first
1
2

Compare providers for flights from San Francisco to Santa Cruz de la Sierra

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from San Francisco to Santa Cruz de la Sierra in March.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
OvagoPrice Accuracy2 starsTrust Score*3 stars
AranGrantPrice Accuracy2 starsTrust Score*2 stars
CheapfaremartPrice Accuracy-Trust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on San Francisco-Santa Cruz de la Sierra flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on San Francisco-Santa Cruz de la Sierra flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from San Francisco-Santa Cruz de la Sierra flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on San Francisco-Santa Cruz de la Sierra flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Francisco-Santa Cruz de la Sierra flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from San Francisco to Santa Cruz de la Sierra

Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from San Francisco with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Francisco to Santa Cruz de la Sierra

What is the cheapest month to book a flight from San Francisco to Santa Cruz de la Sierra?

Currently, March is the cheapest month in which you can book a flight from San Francisco to Santa Cruz de la Sierra (average of $317). Flying from San Francisco to Santa Cruz de la Sierra in May is currently the most expensive (average of $811). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Santa Cruz de la Sierra

Get insights into the airlines that provide service to Santa Cruz de la Sierra. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Cruz de la Sierra. Reviews last updated March 14, 2026.
Get a feel of what it's like to fly with Copa Airlines,United Airlines, andAvianca from San Francisco to Santa Cruz de la Sierra by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.5
Good
1,570 reviews

Overall

7.5

Comfort

7.4

Entertainment

6.8

Boarding

7.8

Crew

8.1

Food

6.8

Reviews

1 / 20
2.0
Mediocre

Katerine,Mar 2026

LAX - PTY

Really i was expecting be more friendly with family’s, more when you travel with a infant. We expected like a priority to boarding or be friendly with the spots on the aeroplane.
Copa Airlines
7.5
Good
1,570 reviews
Copa Airlines
7.5
Good
1,570 reviews

Overall

7.5

Comfort

7.4

Entertainment

6.8

Boarding

7.8

Crew

8.1

Food

6.8

Reviews

1 / 20
2.0
Mediocre

Katerine,Mar 2026

LAX - PTY

Really i was expecting be more friendly with family’s, more when you travel with a infant. We expected like a priority to boarding or be friendly with the spots on the aeroplane.
United Airlines
7.4
Good
9,422 reviews
Copa Airlines
7.5
Good
1,570 reviews

Overall

7.5

Comfort

7.4

Entertainment

6.8

Boarding

7.8

Crew

8.1

Food

6.8

Reviews

1 / 20
2.0
Mediocre

Katerine,Mar 2026

LAX - PTY

Really i was expecting be more friendly with family’s, more when you travel with a infant. We expected like a priority to boarding or be friendly with the spots on the aeroplane.
Avianca
6.5
Okay
2,499 reviews
Copa Airlines
7.5
Good
1,570 reviews

Overall

7.5

Comfort

7.4

Entertainment

6.8

Boarding

7.8

Crew

8.1

Food

6.8

Reviews

1 / 20
2.0
Mediocre

Katerine,Mar 2026

LAX - PTY

Really i was expecting be more friendly with family’s, more when you travel with a infant. We expected like a priority to boarding or be friendly with the spots on the aeroplane.

Related info for your journey

Find useful and relevant information for your journey from San Francisco to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from San Francisco to Santa Cruz de la Sierra?

    For as low as $714, Copa Airlines can have you in Santa Cruz de la Sierra from San Francisco in 18h 19m. The distance from San Francisco to Santa Cruz de la Sierra is about 5414 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from San Francisco to Santa Cruz de la Sierra round-trip?

    Cheapflights users have booked flights from San Francisco to Santa Cruz de la Sierra round-trip from $622. Other airlines that can offer you cheap pricing are Avianca, from $633, and United Airlines, from $637. Copa Airlines is priced at 29% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from San Francisco to Santa Cruz de la Sierra that include hotel bookings?

    Yes. In addition to deals on San Francisco to Santa Cruz de la Sierra flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from San Francisco to Santa Cruz de la Sierra?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Francisco to Santa Cruz de la Sierra.

  • Can I find deals for business class flights from San Francisco to Santa Cruz de la Sierra?

    Yes. Cheapflights offers flight deals from San Francisco to Santa Cruz de la Sierra by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from San Francisco to Santa Cruz de la Sierra?

    Currently, March is the cheapest month in which you can book a flight from San Francisco to Santa Cruz de la Sierra (average of $317). Flying from San Francisco to Santa Cruz de la Sierra in May is currently the most expensive (average of $811). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top 3 airlines flying from San Francisco to Santa Cruz de la Sierra

Discover the top 3 airlines that operate flights from San Francisco to Santa Cruz de la Sierra. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 14, 2026.
AirlineCheapestAverageFlexibilityOn-time
Copa AirlinesCheapest$622Average$838FlexibilityNo cancel feeOn-time70%
AviancaCheapest$633Average$777FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$637Average$925FlexibilityNo cancel feeOn-time69%

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