HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Santa Cruz de la Sierra

$299+ Cheap flights from San Francisco (SFO) to Santa Cruz de la Sierra (VVI)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/21. Fares are subject to change and may not be available on all flights or dates of travel.
SFO — VVI
Oct 14 — Oct 211
Tue 10/14
Tue 10/21
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from San Francisco to Santa Cruz de la Sierra with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from San Francisco to Santa Cruz de la Sierra

Discover tips and strategies to find the most affordable flight options for your journey from San Francisco (SFO) to Santa Cruz de la Sierra (VVI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 14, 2025.

Round-trip from

$617
(Cheapflightsfares)

One-way from

$299
(United Airlines)

Popular in

December

Cheapest in

March

Average price

$741
From San Francisco to Santa Cruz de la Sierra Viru Viru Intl
Search Deals
One-way flight from San Francisco to Santa Cruz de la Sierra Viru Viru Intl
Search Deals
Highest demand for flights based on searches. 15% potential increase in price ($164 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($58 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in September 2025
Search Deals

Find flight deals from San Francisco to Santa Cruz de la Sierra

Cheapest flights from San Francisco to Santa Cruz de la Sierra
Explore the most affordable flight options available from San Francisco to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 14, 2025.

This Cheapflightsfares deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/112:05 amSFO - VVI
2 stops22h 45mAvianca
Tue 10/72:50 amVVI - SFO
2 stops22h 55mAvianca
Deal found 9/12$617
This Copa Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/412:36 amSFO - VVI
1 stop23h 00mCopa Airlines
Tue 11/1811:40 amVVI - SFO
1 stop15h 37mCopa Airlines
Deal found 9/12$623
This Cheapflightsfares deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/112:05 amSFO - VVI
2 stops22h 45mAvianca
Thu 10/92:50 amVVI - SFO
2 stops22h 55mAvianca
Deal found 9/12$627
This Priceline deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/272:20 pmSFO - VVI
2 stops33h 15mAvianca
Sun 11/23:40 amVVI - SFO
2 stops22h 10mAvianca
Deal found 9/11$633
This Cheapflightsfares deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/22:20 pmSFO - VVI
2 stops32h 30mAvianca
Wed 10/82:50 amVVI - SFO
2 stops24h 05mAvianca
Deal found 9/12$634
This United deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/412:43 amSFO - VVI
2 stops18h 03mMultiple Airlines
Sun 11/163:40 amVVI - SFO
2 stops24h 32mMultiple Airlines
Deal found 9/12$636
This United Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1310:54 amSFO - VVI
2 stops31h 52mUnited Airlines
Wed 11/191:09 amVVI - SFO
2 stops36h 29mUnited Airlines
Deal found 9/12$637
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/2510:36 pmSFO - VVI
2 stops44h 49mUnited Airlines
Mon 11/171:09 amVVI - SFO
2 stops36h 27mUnited Airlines
Deal found 9/14$644
This United deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/66:45 pmSFO - VVI
2 stops48h 01mMultiple Airlines
Wed 11/123:40 amVVI - SFO
2 stops23h 19mMultiple Airlines
Deal found 9/12$645
This United Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/66:45 pmSFO - VVI
2 stops48h 01mUnited Airlines
Mon 11/171:09 amVVI - SFO
2 stops36h 27mUnited Airlines
Deal found 9/12$646

Cheapflights Fare Finder

 
Customize your flight search to find flights from San Francisco to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 14, 2025.
Use the filters below to find and compare flights from San Francisco to Santa Cruz de la Sierra that are best for you.

Fly from

San Francisco

Fly to

Santa Cruz de la Sierra

Route

Depart

Return

Price

San FranciscoSanta Cruz de la Sierra

SFO - VVI

SFOVVI

San Francisco

Wed 11/5

11:10 pm-2:35 am

2 stops23h 25m

Santa Cruz de la Sierra Viru Viru Intl

Mon 11/17

3:40 am-9:50 pm

2 stops22h 10m

$617

San FranciscoSanta Cruz de la Sierra

SFO - VVI

SFOVVI

San Francisco

Wed 11/5

11:10 pm-2:35 am

2 stops23h 25m

Santa Cruz de la Sierra Viru Viru Intl

Sun 11/16

3:40 am-9:50 pm

2 stops22h 10m

$617

San FranciscoSanta Cruz de la Sierra

SFO - VVI

SFOVVI

San Francisco

Thu 11/6

11:10 pm-2:35 am

2 stops23h 25m

Santa Cruz de la Sierra Viru Viru Intl

Sun 11/16

3:40 am-9:50 pm

2 stops22h 10m

$617

San FranciscoSanta Cruz de la Sierra

SFO - VVI

SFOVVI

San Francisco

Thu 11/6

11:10 pm-2:35 am

2 stops23h 25m

Santa Cruz de la Sierra Viru Viru Intl

Mon 11/17

3:40 am-9:50 pm

2 stops22h 10m

$617

San FranciscoSanta Cruz de la Sierra

SFO - VVI

SFOVVI

San Francisco

Wed 10/1

12:05 am-1:50 am

2 stops22h 45m

Santa Cruz de la Sierra Viru Viru Intl

Tue 10/7

2:50 am-10:45 pm

2 stops22h 55m

$617

San FranciscoSanta Cruz de la Sierra

SFO - VVI

SFOVVI

San Francisco

Tue 11/4

12:36 am-3:36 am

1 stop23h 00m

Santa Cruz de la Sierra Viru Viru Intl

Tue 11/18

11:40 am-11:17 pm

1 stop15h 37m

$623

San FranciscoSanta Cruz de la Sierra

SFO - VVI

SFOVVI

San Francisco

Tue 11/4

12:36 am-10:46 pm

1 stop18h 10m

Santa Cruz de la Sierra Viru Viru Intl

Thu 11/13

11:40 am-11:17 pm

1 stop15h 37m

$623

San FranciscoSanta Cruz de la Sierra

SFO - VVI

SFOVVI

San Francisco

Wed 10/1

12:05 am-1:50 am

2 stops22h 45m

Santa Cruz de la Sierra Viru Viru Intl

Thu 10/9

2:50 am-10:45 pm

2 stops22h 55m

$627

San FranciscoSanta Cruz de la Sierra

SFO - VVI

SFOVVI

San Francisco

Sun 9/28

11:56 pm-10:25 pm

2 stops43h 29m

$299

San FranciscoSanta Cruz de la Sierra

SFO - VVI

SFOVVI

San Francisco

Thu 9/25

12:43 am-10:25 pm

2 stops42h 42m

$299

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/12

Showing 1-10 of 11 results
1
2

Best time to book a flight from San Francisco to Santa Cruz de la Sierra

Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from San Francisco with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Francisco to Santa Cruz de la Sierra

What is the cheapest month to book a flight from San Francisco to Santa Cruz de la Sierra?

Currently, October is the cheapest month in which you can book a flight from San Francisco to Santa Cruz de la Sierra (average of $597). Flying from San Francisco to Santa Cruz de la Sierra in December is currently the most expensive (average of $822). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SFO to VVI?

Find hourly flight availability from San Francisco to Santa Cruz de la Sierra. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 14, 2025.

It’s optimal to fly from San Francisco to Santa Cruz de la Sierra at noon. By choosing this option you can save up to 26% on the cost of your flight, compared to a flight in the afternoon.

Reviews of airlines servicing Santa Cruz de la Sierra

Get insights into the airlines that provide service to Santa Cruz de la Sierra. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Cruz de la Sierra. Reviews last updated September 14, 2025.
Get a feel of what it's like to fly with Copa Airlines, United Airlines, and Avianca from San Francisco to Santa Cruz de la Sierra by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,531 reviews

Overall

7.6

Crew

8.1

Comfort

7.4

Entertainment

6.8

Food

6.8

Boarding

7.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Copa Airlines
7.6
Good
1,531 reviews
Copa Airlines
7.6
Good
1,531 reviews

Overall

7.6

Crew

8.1

Comfort

7.4

Entertainment

6.8

Food

6.8

Boarding

7.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
United Airlines
7.4
Good
8,934 reviews
Copa Airlines
7.6
Good
1,531 reviews

Overall

7.6

Crew

8.1

Comfort

7.4

Entertainment

6.8

Food

6.8

Boarding

7.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Avianca
6.7
Okay
2,435 reviews
Copa Airlines
7.6
Good
1,531 reviews

Overall

7.6

Crew

8.1

Comfort

7.4

Entertainment

6.8

Food

6.8

Boarding

7.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip

Related info for your journey

Find useful and relevant information for your journey from San Francisco to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from San Francisco to Santa Cruz de la Sierra?

    For as low as $617, Avianca can have you in Santa Cruz de la Sierra from San Francisco in 23h 25m. The distance from San Francisco to Santa Cruz de la Sierra is about 5414 mi.

  • What are the cheapest airlines flying from San Francisco to Santa Cruz de la Sierra round-trip?

    Cheapflights users have booked flights from San Francisco to Santa Cruz de la Sierra round-trip from $585. Other airlines that can offer you cheap pricing are United Airlines, from $589, and Copa Airlines, from $608. Avianca is priced at 36% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from San Francisco to Santa Cruz de la Sierra that include hotel bookings?

    Yes. In addition to deals on San Francisco to Santa Cruz de la Sierra flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from San Francisco to Santa Cruz de la Sierra?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Francisco to Santa Cruz de la Sierra.

  • Can I find deals for business class flights from San Francisco to Santa Cruz de la Sierra?

    Yes. Cheapflights offers flight deals from San Francisco to Santa Cruz de la Sierra by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from San Francisco to Santa Cruz de la Sierra?

    Currently, October is the cheapest month in which you can book a flight from San Francisco to Santa Cruz de la Sierra (average of $597). Flying from San Francisco to Santa Cruz de la Sierra in December is currently the most expensive (average of $822). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for San Francisco to Santa Cruz de la Sierra

See prices for flight routes from nearby airports that may be better suited for you.
Los Angeles to Santa Cruz de la Sierra flights
Los Angeles to La Paz flights
San Francisco to La Paz flights
San Diego to La Paz flights
Los Angeles to Cochabamba flights
Ontario to Santa Cruz de la Sierra flights
Las Vegas to La Paz flights
San Jose to La Paz flights
Las Vegas to Santa Cruz de la Sierra flights
Ontario to La Paz flights
San Diego to Santa Cruz de la Sierra flights
Santa Ana to La Paz flights
Long Beach to La Paz flights
Sacramento to La Paz flights
San Jose to Santa Cruz de la Sierra flights
Reno to La Paz flights
Santa Ana to Santa Cruz de la Sierra flights
San Francisco to Sucre flights
San Francisco to Cochabamba flights
Burbank to La Paz flights
Oakland to La Paz flights
Los Angeles to Trinidad flights
Burbank to Santa Cruz de la Sierra flights

Top 3 airlines flying from San Francisco to Santa Cruz de la Sierra

Discover the top 3 airlines that operate flights from San Francisco to Santa Cruz de la Sierra. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$585Average$892FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$589Average$899FlexibilityNo cancel feeOn-time69%
Copa AirlinesCheapest$608Average$921FlexibilityNo cancel feeOn-time70%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.