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Santa Cruz de la Sierra

$310+ Cheap flights from San Francisco (SFO) to Santa Cruz de la Sierra (VVI)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/9. Fares are subject to change and may not be available on all flights or dates of travel.
SFO — VVI
feb. 26 — mar. 51
jue. 2/26
jue. 3/5
1 adult, Economy
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Cheap flight deals from San Francisco to Santa Cruz de la Sierra

Cheapest flights from San Francisco to Santa Cruz de la Sierra
Explore the most affordable flight options available from San Francisco to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on enero 27, 2026.

This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 4/87:00 am
SFO
-
VVI
2 stops17h 40m
United Airlines
jue. 4/2311:48 am
VVI
-
SFO
2 stops24h 01m
United Airlines
Deal found 1/27$659
This Copa Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 8/301:12 am
SFO
-
VVI
1 stop18h 28m
Copa Airlines
mié. 9/301:12 am
VVI
-
SFO
1 stop19h 58m
Copa Airlines
Deal found 1/27$664
This United Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 4/26:40 am
SFO
-
VVI
2 stops42h 00m
United Airlines
sáb. 4/1811:48 am
VVI
-
SFO
2 stops46h 28m
United Airlines
Deal found 1/26$667
This BusinessClass deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 4/71:23 am
SFO
-
VVI
1 stop18h 19m
Copa Airlines
mié. 4/221:15 am
VVI
-
SFO
1 stop20h 10m
Copa Airlines
Deal found 1/26$694
This United Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 4/146:25 pm
SFO
-
VVI
2 stops30h 15m
United Airlines
sáb. 4/1811:48 am
VVI
-
SFO
2 stops46h 17m
United Airlines
Deal found 1/26$696
This Ovago deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 4/112:45 am
SFO
-
VVI
2 stops18h 57m
Copa Airlines
sáb. 4/1811:48 am
VVI
-
SFO
2 stops46h 28m
Copa Airlines
Deal found 1/24$702
This Copa Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 4/71:23 am
SFO
-
VVI
1 stop18h 19m
Copa Airlines
mar. 4/211:15 am
VVI
-
SFO
1 stop20h 10m
Copa Airlines
Deal found 1/27$712
This BusinessClass deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 4/98:35 pm
SFO
-
VVI
1 stop28h 05m
Copa Airlines
mié. 4/221:15 am
VVI
-
SFO
1 stop20h 10m
Copa Airlines
Deal found 1/25$714
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 8/2912:45 am
SFO
-
VVI
2 stops18h 55m
United Airlines
jue. 10/111:47 am
VVI
-
SFO
2 stops22h 48m
United Airlines
Deal found 1/27$733
This Copa Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 8/308:21 pm
SFO
-
VVI
1 stop23h 19m
Copa Airlines
lun. 9/2811:47 am
VVI
-
SFO
1 stop14h 53m
Copa Airlines
Deal found 1/26$739
This Ovago deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 4/1512:45 am
SFO
-
VVI
2 stops18h 57m
Multiple Airlines
dom. 5/312:00 pm
VVI
-
SFO
2 stops46h 15m
Multiple Airlines
Deal found 1/26$746
This Ovago deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 4/1512:45 am
SFO
-
VVI
2 stops18h 57m
Multiple Airlines
dom. 5/1012:00 pm
VVI
-
SFO
2 stops36h 49m
Multiple Airlines
Deal found 1/26$748

Find flight deals from San Francisco to Santa Cruz de la Sierra

Discover tips and strategies to find the most affordable flight options for your journey from San Francisco (SFO) to Santa Cruz de la Sierra (VVI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated enero 27, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$659
(United Airlines)

One-way from

$310
(United Airlines)

Popular in

December

Cheapest in

September

Average price

$1,103
Provider with most accurate pricing for San Francisco-Santa Cruz de la Sierra Viru Viru Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for San Francisco-Santa Cruz de la Sierra Viru Viru Intl flights.
Search Deals
From San Francisco to Santa Cruz de la Sierra Viru Viru Intl
Search Deals
One-way flight from San Francisco to Santa Cruz de la Sierra Viru Viru Intl
Search Deals
Highest demand for flights based on searches. 14% potential increase in price ($167 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($59 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from San Francisco to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated enero 27, 2026.
Use the filters below to find and compare flights from San Francisco to Santa Cruz de la Sierra that are best for you.

Fly from

San Francisco

Fly to

Santa Cruz de la Sierra

Route

Depart

Return

Price

San FranciscoSanta Cruz de la Sierra

SFO - VVI

SFOVVI

San Francisco

mié. 4/1

12:45 am-10:42 pm

2 stops18h 57m

Santa Cruz de la Sierra Viru Viru Intl

sáb. 4/18

11:48 am-7:16 am

2 stops46h 28m

$659

San FranciscoSanta Cruz de la Sierra

SFO - VVI

SFOVVI

San Francisco

sáb. 4/4

6:55 pm-10:42 pm

2 stops24h 47m

Santa Cruz de la Sierra Viru Viru Intl

lun. 4/13

11:48 am-6:58 pm

2 stops34h 10m

$659

San FranciscoSanta Cruz de la Sierra

SFO - VVI

SFOVVI

San Francisco

mié. 4/15

12:45 am-10:42 pm

2 stops18h 57m

Santa Cruz de la Sierra Viru Viru Intl

jue. 4/30

11:48 am-7:05 pm

2 stops34h 17m

$659

San FranciscoSanta Cruz de la Sierra

SFO - VVI

SFOVVI

San Francisco

mié. 4/8

12:45 am-10:42 pm

2 stops18h 57m

Santa Cruz de la Sierra Viru Viru Intl

jue. 4/23

11:48 am-6:58 pm

2 stops34h 10m

$659

San FranciscoSanta Cruz de la Sierra

SFO - VVI

SFOVVI

San Francisco

mar. 4/7

1:23 am-10:42 pm

1 stop18h 19m

Santa Cruz de la Sierra Viru Viru Intl

mié. 4/22

1:15 am-6:25 pm

1 stop20h 10m

$694

San FranciscoSanta Cruz de la Sierra

SFO - VVI

SFOVVI

San Francisco

mar. 4/14

6:25 pm-3:40 am

2 stops30h 15m

Santa Cruz de la Sierra Viru Viru Intl

sáb. 4/18

11:48 am-7:05 am

2 stops46h 17m

$696

San FranciscoSanta Cruz de la Sierra

SFO - VVI

SFOVVI

San Francisco

jue. 4/9

11:59 pm-10:42 pm

2 stops19h 43m

Santa Cruz de la Sierra Viru Viru Intl

jue. 4/23

11:48 am-6:58 pm

2 stops34h 10m

$702

San FranciscoSanta Cruz de la Sierra

SFO - VVI

SFOVVI

San Francisco

mar. 4/7

1:23 am-10:42 pm

1 stop18h 19m

Santa Cruz de la Sierra Viru Viru Intl

mar. 4/21

1:15 am-6:25 pm

1 stop20h 10m

$712

San FranciscoSanta Cruz de la Sierra

SFO - VVI

SFOVVI

San Francisco

jue. 4/9

12:45 am-10:42 pm

2 stops18h 57m

$310

San FranciscoSanta Cruz de la Sierra

SFO - VVI

SFOVVI

San Francisco

vie. 5/29

12:45 am-10:38 pm

2 stops18h 53m

$340

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/25

Showing 1-10 of 16 results
1
2

Compare providers for flights from San Francisco to Santa Cruz de la Sierra

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from San Francisco to Santa Cruz de la Sierra in January.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
AranGrantPrice Accuracy2 starsTrust Score*2 stars
OvagoPrice Accuracy2 starsTrust Score*3 stars
CheapfaremartPrice Accuracy-Trust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on San Francisco-Santa Cruz de la Sierra flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on San Francisco-Santa Cruz de la Sierra flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from San Francisco-Santa Cruz de la Sierra flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on San Francisco-Santa Cruz de la Sierra flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Francisco-Santa Cruz de la Sierra flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from San Francisco to Santa Cruz de la Sierra

Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from San Francisco with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Francisco to Santa Cruz de la Sierra

What is the cheapest month to book a flight from San Francisco to Santa Cruz de la Sierra?

Currently, April is the cheapest month in which you can book a flight from San Francisco to Santa Cruz de la Sierra (average of $355). Flying from San Francisco to Santa Cruz de la Sierra in July is currently the most expensive (average of $921). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Santa Cruz de la Sierra

Get insights into the airlines that provide service to Santa Cruz de la Sierra. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Cruz de la Sierra. Reviews last updated enero 27, 2026.
Get a feel of what it's like to fly with Copa Airlines, United Airlines, and Avianca from San Francisco to Santa Cruz de la Sierra by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,558 reviews

Comfort

7.4

Boarding

7.8

Food

6.8

Entertainment

6.8

Crew

8.1

Overall

7.6

Reviews

1 / 20
2.0
Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it
Copa Airlines
7.6
Good
1,558 reviews
Copa Airlines
7.6
Good
1,558 reviews

Comfort

7.4

Boarding

7.8

Food

6.8

Entertainment

6.8

Crew

8.1

Overall

7.6

Reviews

1 / 20
2.0
Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it
United Airlines
7.4
Good
9,205 reviews
Copa Airlines
7.6
Good
1,558 reviews

Comfort

7.4

Boarding

7.8

Food

6.8

Entertainment

6.8

Crew

8.1

Overall

7.6

Reviews

1 / 20
2.0
Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it
Avianca
6.6
Okay
2,487 reviews
Copa Airlines
7.6
Good
1,558 reviews

Comfort

7.4

Boarding

7.8

Food

6.8

Entertainment

6.8

Crew

8.1

Overall

7.6

Reviews

1 / 20
2.0
Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it

Related info for your journey

Find useful and relevant information for your journey from San Francisco to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from San Francisco to Santa Cruz de la Sierra?

    For as low as $659, United Airlines can have you in Santa Cruz de la Sierra from San Francisco in 18h 57m. The distance from San Francisco to Santa Cruz de la Sierra is about 5414 mi.

  • What are the cheapest airlines flying from San Francisco to Santa Cruz de la Sierra round-trip?

    Cheapflights users have booked flights from San Francisco to Santa Cruz de la Sierra round-trip from $622. Other airlines that can offer you cheap pricing are Avianca, from $633, and United Airlines, from $644. Copa Airlines is priced at 34% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from San Francisco to Santa Cruz de la Sierra that include hotel bookings?

    Yes. In addition to deals on San Francisco to Santa Cruz de la Sierra flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from San Francisco to Santa Cruz de la Sierra?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Francisco to Santa Cruz de la Sierra.

  • Can I find deals for business class flights from San Francisco to Santa Cruz de la Sierra?

    Yes. Cheapflights offers flight deals from San Francisco to Santa Cruz de la Sierra by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from San Francisco to Santa Cruz de la Sierra?

    Currently, April is the cheapest month in which you can book a flight from San Francisco to Santa Cruz de la Sierra (average of $355). Flying from San Francisco to Santa Cruz de la Sierra in July is currently the most expensive (average of $921). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for San Francisco to Santa Cruz de la Sierra

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from San Francisco to Santa Cruz de la Sierra

Discover the top 3 airlines that operate flights from San Francisco to Santa Cruz de la Sierra. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated enero 27, 2026.
AirlineCheapestAverageFlexibilityOn-time
Copa AirlinesCheapest$622Average$951FlexibilityNo cancel feeOn-time70%
AviancaCheapest$633Average$816FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$644Average$925FlexibilityNo cancel feeOn-time69%

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