$259+ Cheap flights from Panama City (PTY) to Santa Cruz de la Sierra (VVI)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/29. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — VVI
Mar 6 — Mar 131
1 adult, Economy
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Find cheap flights from Panama City to Santa Cruz de la Sierra with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Panama City Tocumen Intl to Santa Cruz de la Sierra Viru Viru Intl are usually found in April or June, booked 65 days in advance, depart on a Monday or Thursday and return on a Saturday
Cheap flight deals from Panama City to Santa Cruz de la Sierra
Cheapest
Best
Last-minute
One-way
Cheapest flights from Panama City to Santa Cruz de la SierraExplore the most affordable flight options available from Panama City to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 4, 2026.
Explore the most affordable flight options available from Panama City to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 4, 2026.
This Avianca deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/285:50 pm
PTY
- VVI
1 stop7h 45m
Avianca
Fri 3/63:40 am
VVI
- PTY
1 stop14h 15m
Avianca
Deal found 2/3![Avianca logo]()
$492
This Avianca deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/303:10 pm
PTY
- VVI
1 stop10h 20m
Avianca
Fri 6/53:35 am
VVI
- PTY
1 stop14h 25m
Avianca
Deal found 2/3![Avianca logo]()
$552
This Copa Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/14:40 pm
PTY
- VVI
Nonstop4h 58m
Copa Airlines
Sat 5/2311:47 am
VVI
- PTY
Nonstop4h 52m
Copa Airlines
Deal found 2/3![Copa Airlines logo]()
$555
This Copa Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/59:43 pm
PTY
- VVI
Nonstop4h 52m
Copa Airlines
Sun 7/121:12 am
VVI
- PTY
Nonstop4h 52m
Copa Airlines
Deal found 2/2![Copa Airlines logo]()
$573
This Avianca deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/242:55 pm
PTY
- VVI
1 stop10h 40m
Avianca
Wed 2/253:40 am
VVI
- PTY
1 stop14h 15m
Avianca
Deal found 2/2![Avianca logo]()
$591
This Copa Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/74:40 pm
PTY
- VVI
Nonstop5h 00m
Copa Airlines
Sun 7/121:12 am
VVI
- PTY
Nonstop4h 52m
Copa Airlines
Deal found 2/3![Copa Airlines logo]()
$595
This Copa Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/284:40 pm
PTY
- VVI
Nonstop5h 10m
Copa Airlines
Fri 3/61:14 am
VVI
- PTY
Nonstop4h 50m
Copa Airlines
Deal found 2/3![Copa Airlines logo]()
$678
This Copa Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/54:40 pm
PTY
- VVI
Nonstop5h 00m
Copa Airlines
Thu 7/91:12 am
VVI
- PTY
Nonstop4h 52m
Copa Airlines
Deal found 2/3![Copa Airlines logo]()
$710
This FlightHub deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/245:50 pm
PTY
- VVI
2 stops11h 45m
Multiple Airlines
Wed 2/253:40 am
VVI
- PTY
1 stop11h 20m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$728
This FlightHub deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/265:50 pm
PTY
- VVI
1 stop7h 45m
Multiple Airlines
Thu 4/29:50 pm
VVI
- PTY
2 stops12h 25m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$760
Best flights from Panama City to Santa Cruz de la SierraDiscover carefully curated flight deals from Panama City to Santa Cruz de la Sierra that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 4, 2026.
Discover carefully curated flight deals from Panama City to Santa Cruz de la Sierra that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 4, 2026.
This Avianca deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/303:10 pm
PTY
- VVI
1 stop10h 20m
Avianca
Fri 6/53:35 am
VVI
- PTY
1 stop14h 25m
Avianca
Deal found 2/3![Avianca logo]()
$552
This Copa Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/14:40 pm
PTY
- VVI
Nonstop4h 58m
Copa Airlines
Sat 5/2311:47 am
VVI
- PTY
Nonstop4h 52m
Copa Airlines
Deal found 2/2![Copa Airlines logo]()
$555
This FlightHub deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/245:50 pm
PTY
- VVI
2 stops11h 45m
Multiple Airlines
Wed 2/253:40 am
VVI
- PTY
1 stop11h 20m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$728
This Copa Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/59:43 pm
PTY
- VVI
Nonstop4h 52m
Copa Airlines
Sun 7/121:12 am
VVI
- PTY
Nonstop4h 52m
Copa Airlines
Deal found 2/2![Copa Airlines logo]()
$573
This Avianca deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/242:55 pm
PTY
- VVI
1 stop10h 40m
Avianca
Wed 2/253:40 am
VVI
- PTY
1 stop14h 15m
Avianca
Deal found 2/2![Avianca logo]()
$591
This Copa Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/74:40 pm
PTY
- VVI
Nonstop5h 00m
Copa Airlines
Sun 7/121:12 am
VVI
- PTY
Nonstop4h 52m
Copa Airlines
Deal found 2/3![Copa Airlines logo]()
$595
This Copa Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/74:40 pm
PTY
- VVI
Nonstop5h 00m
Copa Airlines
Mon 7/131:12 am
VVI
- PTY
Nonstop4h 52m
Copa Airlines
Deal found 2/2![Copa Airlines logo]()
$595
This Copa Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/284:40 pm
PTY
- VVI
Nonstop5h 10m
Copa Airlines
Fri 3/61:14 am
VVI
- PTY
Nonstop4h 50m
Copa Airlines
Deal found 2/3![Copa Airlines logo]()
$678
This Copa Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/14:40 pm
PTY
- VVI
Nonstop5h 10m
Copa Airlines
Sat 3/141:14 am
VVI
- PTY
Nonstop4h 50m
Copa Airlines
Deal found 2/3![Copa Airlines logo]()
$678
This Copa Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/54:40 pm
PTY
- VVI
Nonstop5h 00m
Copa Airlines
Thu 7/91:12 am
VVI
- PTY
Nonstop4h 52m
Copa Airlines
Deal found 2/3![Copa Airlines logo]()
$710
Last-minute flights from Panama City to Santa Cruz de la SierraDiscover last-minute flight deals from Panama City to Santa Cruz de la Sierra. Data last updated February 4, 2026 and is based on user searches.
Discover last-minute flight deals from Panama City to Santa Cruz de la Sierra. Data last updated February 4, 2026 and is based on user searches.
This Avianca deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/242:55 pm
PTY
- VVI
1 stop10h 40m
Avianca
Wed 2/253:40 am
VVI
- PTY
1 stop14h 15m
Avianca
Deal found 2/2![Avianca logo]()
$591
This FlightHub deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/249:45 am
PTY
- VVI
1 stop15h 50m
Multiple Airlines
Thu 2/2611:00 am
VVI
- PTY
3 stops15h 00m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$728
This Copa Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/244:40 pm
PTY
- VVI
Nonstop5h 10m
Copa Airlines
Wed 2/251:15 am
VVI
- PTY
Nonstop4h 49m
Copa Airlines
Deal found 2/2![Copa Airlines logo]()
$839
This Avianca deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/285:50 pm
PTY
- VVI
1 stop7h 45m
Avianca
Fri 3/63:40 am
VVI
- PTY
1 stop14h 15m
Avianca
Deal found 2/3![Avianca logo]()
$492
This Copa Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/284:40 pm
PTY
- VVI
Nonstop5h 10m
Copa Airlines
Fri 3/61:14 am
VVI
- PTY
Nonstop4h 50m
Copa Airlines
Deal found 2/3![Copa Airlines logo]()
$678
This FlightHub deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/2811:25 am
PTY
- VVI
2 stops38h 10m
Multiple Airlines
Sat 3/77:20 am
VVI
- PTY
3 stops18h 40m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$896
This Avianca deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/1911:25 am
PTY
- VVI
2 stops14h 10m
Avianca
Wed 3/253:40 am
VVI
- PTY
1 stop14h 15m
Avianca
Deal found 2/2![Avianca logo]()
$824
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/197:04 pm
PTY
- VVI
1 stop8h 31m
Multiple Airlines
Thu 3/265:25 am
VVI
- PTY
1 stop9h 47m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$928
This FlightHub deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/265:50 pm
PTY
- VVI
1 stop7h 45m
Multiple Airlines
Thu 4/29:50 pm
VVI
- PTY
2 stops12h 25m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$760
One-way flights from Panama City to Santa Cruz de la SierraSearch for one-way flight options from Panama City to Santa Cruz de la Sierra. Find affordable one-way fares based on user searches. Data last updated February 4, 2026.
Search for one-way flight options from Panama City to Santa Cruz de la Sierra. Find affordable one-way fares based on user searches. Data last updated February 4, 2026.
This Avianca deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/293:10 pm
PTY
- VVI
1 stop10h 20m
Avianca
Deal found 2/2![Avianca logo]()
$259
This Avianca deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/259:45 am
PTY
- VVI
1 stop15h 50m
Avianca
Deal found 2/2![Avianca logo]()
$262
This FlightHub deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/252:55 am
PTY
- VVI
1 stop22h 40m
Avianca
Deal found 2/2![Avianca logo]()
$282
This Avianca deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/1810:10 am
PTY
- VVI
1 stop15h 20m
Avianca
Deal found 2/2![Avianca logo]()
$288
This FlightHub deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/232:55 am
PTY
- VVI
1 stop22h 40m
Avianca
Deal found 2/2![Avianca logo]()
$321
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/193:25 am
PTY
- VVI
3 stops20h 25m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$339
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/195:55 pm
PTY
- VVI
2 stops13h 15m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$351
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/232:55 am
PTY
- VVI
3 stops16h 40m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$353
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/225:55 pm
PTY
- VVI
2 stops13h 15m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$365
This Avianca deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/172:55 am
PTY
- VVI
1 stop22h 40m
Avianca
Deal found 2/2![Avianca logo]()
$431
This FlightHub deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/162:55 pm
PTY
- VVI
2 stops16h 15m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$439
Find flight deals from Panama City to Santa Cruz de la Sierra
Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Santa Cruz de la Sierra (VVI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 4, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $492 (Avianca) |
One-way from | $259 (Avianca) |
Popular in | January |
Cheapest in | April |
Average price | $635 |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama City to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 4, 2026.
Use the filters below to find and compare flights from Panama City to Santa Cruz de la Sierra that are best for you.
Fly from
Panama City
Fly to
Santa Cruz de la Sierra
Route
Depart
Return
Price
Panama CitySanta Cruz de la Sierra
PTY - VVI
PTYVVI
Panama City Tocumen Intl
Sat 5/30
3:10 pm-2:30 am
1 stop10h 20m
Santa Cruz de la Sierra Viru Viru Intl
Fri 6/5
3:35 am-5:00 pm
1 stop14h 25m
$552
Panama CitySanta Cruz de la Sierra
PTY - VVI
PTYVVI
Panama City Tocumen Intl
Fri 5/1
4:40 pm-10:38 pm
Nonstop4h 58m
Santa Cruz de la Sierra Viru Viru Intl
Sat 5/23
11:47 am-3:39 pm
Nonstop4h 52m
$555
Panama CitySanta Cruz de la Sierra
PTY - VVI
PTYVVI
Panama City Tocumen Intl
Sun 7/5
9:43 pm-3:35 am
Nonstop4h 52m
Santa Cruz de la Sierra Viru Viru Intl
Sun 7/12
1:12 am-5:04 am
Nonstop4h 52m
$573
Panama CitySanta Cruz de la Sierra
PTY - VVI
PTYVVI
Panama City Tocumen Intl
Tue 2/24
2:55 pm-2:35 am
1 stop10h 40m
Santa Cruz de la Sierra Viru Viru Intl
Wed 2/25
3:40 am-4:55 pm
1 stop14h 15m
$591
Panama CitySanta Cruz de la Sierra
PTY - VVI
PTYVVI
Panama City Tocumen Intl
Tue 7/7
4:40 pm-10:40 pm
Nonstop5h 00m
Santa Cruz de la Sierra Viru Viru Intl
Sun 7/12
1:12 am-5:04 am
Nonstop4h 52m
$595
Panama CitySanta Cruz de la Sierra
PTY - VVI
PTYVVI
Panama City Tocumen Intl
Tue 7/7
4:40 pm-10:40 pm
Nonstop5h 00m
Santa Cruz de la Sierra Viru Viru Intl
Mon 7/13
1:12 am-5:04 am
Nonstop4h 52m
$595
Panama CitySanta Cruz de la Sierra
PTY - VVI
PTYVVI
Panama City Tocumen Intl
Sat 2/28
4:40 pm-10:50 pm
Nonstop5h 10m
Santa Cruz de la Sierra Viru Viru Intl
Fri 3/6
1:14 am-5:04 am
Nonstop4h 50m
$678
Panama CitySanta Cruz de la Sierra
PTY - VVI
PTYVVI
Panama City Tocumen Intl
Sun 3/1
4:40 pm-10:50 pm
Nonstop5h 10m
Santa Cruz de la Sierra Viru Viru Intl
Sat 3/14
1:14 am-5:04 am
Nonstop4h 50m
$678
Panama CitySanta Cruz de la Sierra
PTY - VVI
PTYVVI
Panama City Tocumen Intl
Sun 7/5
4:40 pm-10:40 pm
Nonstop5h 00m
Santa Cruz de la Sierra Viru Viru Intl
Thu 7/9
1:12 am-5:04 am
Nonstop4h 52m
$710
Panama CitySanta Cruz de la Sierra
PTY - VVI
PTYVVI
Panama City Tocumen Intl
Tue 2/24
5:50 pm-6:35 am
2 stops11h 45m
Santa Cruz de la Sierra Viru Viru Intl
Wed 2/25
3:40 am-2:00 pm
1 stop11h 20m
$728
Showing 1-10 of 21 results
- Most accurate provider: When it comes to deals on Panama City-Santa Cruz de la Sierra flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-Santa Cruz de la Sierra flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-Santa Cruz de la Sierra flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Panama City-Santa Cruz de la Sierra flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Santa Cruz de la Sierra flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Panama City to Santa Cruz de la Sierra
Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Panama City with our price prediction graph.
PTY-VVI
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama City to Santa Cruz de la Sierra
Prices
Airlines
Delays
How far ahead should I book a flight from Panama City to Santa Cruz de la Sierra?
Use this chart to determine the optimal time to book a round-trip flight from Panama City to Santa Cruz de la Sierra. Price data was last updated on January 30, 2026.
The price you pay for your flight from Panama City to Santa Cruz de la Sierra may vary depending on when you book. For the best chance of a lower fare, look to book 64 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Panama City to Santa Cruz de la Sierra?
Currently, April is the cheapest month in which you can book a flight from Panama City to Santa Cruz de la Sierra (average of $172). Flying from Panama City to Santa Cruz de la Sierra in December is currently the most expensive (average of $566). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from PTY to VVI?
Find hourly flight availability from Panama City to Santa Cruz de la Sierra. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 4, 2026.
When flying from Panama City to Santa Cruz de la Sierra, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.
How often are flights from Panama City to Santa Cruz de la Sierra delayed?
About 18% of weekly flights between Panama City and Santa Cruz de la Sierra have experienced delays in the past year, with the average delay time being 136 minutes.
What is the most punctual flight time for Panama City to Santa Cruz de la Sierra flights?
Historically, flights departing in the early afternoon are less likely to be delayed, whereas flights leaving at night tend to experience delays more often.
What day of the week experiences the fewest flight delays on this route?
Monday tends to have the lowest number of delays on this route, whereas Sunday has historically faced a higher average of delays compared to other days of the week.
Which airline has the best punctuality record on Panama City to Santa Cruz de la Sierra flights?
Over the last year, Copa Airlines have had the lowest number of delays on this route, with just 13% of flights being delayed.
Reviews of airlines servicing Santa Cruz de la Sierra
Get insights into the airlines that provide service to Santa Cruz de la Sierra. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Cruz de la Sierra. Reviews last updated February 4, 2026.
See what other customers who have flown with Copa Airlines from Panama City to Santa Cruz de la Sierra have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.4
Food
6.8
Overall
7.6
Entertainment
6.8
Boarding
7.8
Crew
8.1
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Comfort
7.4
Food
6.8
Overall
7.6
Entertainment
6.8
Boarding
7.8
Crew
8.1
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Related info for your journey
Find useful and relevant information for your journey from Panama City to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Complete your trip to Santa Cruz de la Sierra by adding a car rental and/or hotel reservation to your travel itinerary.
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Panama City and Santa Cruz de la Sierra flights
Browse other Panama City and Santa Cruz de la Sierra flight options. Last updated on February 4, 2026.
Other flights from Panama City
Browse through other flights departing from Panama City. Flights are based on user searches made on Cheapflights and were last updated on February 4, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top airline flying from Panama City to Santa Cruz de la Sierra
Discover the top airline that operate flights from Panama City to Santa Cruz de la Sierra. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 4, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$356 | Average$619 | FlexibilityNo cancel fee | On-time70% |