HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Santa Cruz de la Sierra

$289+ Cheap flights from Panama City (PTY) to Santa Cruz de la Sierra (VVI)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/5. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — VVI
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Panama City to Santa Cruz de la Sierra with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Panama City Tocumen Intl to Santa Cruz de la Sierra Viru Viru Intl are usually found in April or November, booked 40 days in advance, depart on a Wednesday or Monday and return on a Monday

Cheap flight deals from Panama City to Santa Cruz de la Sierra

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Santa Cruz de la Sierra (VVI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 15, 2025.

Round-trip from

$467
(Copa Airlines)

One-way from

$289
(Priceline)

Popular in

July

Cheapest in

April

Average price

$544
From Panama City Tocumen Intl to Santa Cruz de la Sierra Viru Viru Intl
Search Deals
One-way flight from Panama City Tocumen Intl to Santa Cruz de la Sierra Viru Viru Intl
Search Deals
Highest demand for flights based on searches. 6% potential increase in price ($34 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($12 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in September 2025
Search Deals

Find flight deals from Panama City to Santa Cruz de la Sierra

Cheapest flights from Panama City to Santa Cruz de la Sierra
Explore the most affordable flight options available from Panama City to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This Copa Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/34:40 pmPTY - VVI
Nonstop5h 06mCopa Airlines
Sat 11/811:40 amVVI - PTY
Nonstop4h 55mCopa Airlines
Deal found 9/14$467
This Copa Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/309:43 pmPTY - VVI
Nonstop4h 53mCopa Airlines
Tue 12/231:09 amVVI - PTY
Nonstop4h 55mCopa Airlines
Deal found 9/14$530
This Avianca deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/109:45 amPTY - VVI
1 stop15h 50mAvianca
Tue 12/233:40 amVVI - PTY
1 stop11h 20mAvianca
Deal found 9/14$566
This Copa Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/219:43 pmPTY - VVI
Nonstop4h 53mCopa Airlines
Sat 9/271:09 amVVI - PTY
Nonstop4h 55mCopa Airlines
Deal found 9/14$594
This Copa Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/159:43 pmPTY - VVI
Nonstop4h 53mCopa Airlines
Sat 10/181:09 amVVI - PTY
Nonstop4h 55mCopa Airlines
Deal found 9/13$607
This Copa Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/104:40 pmPTY - VVI
Nonstop5h 06mCopa Airlines
Tue 12/231:09 amVVI - PTY
Nonstop4h 55mCopa Airlines
Deal found 9/15$614
This Copa Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/219:43 pmPTY - VVI
Nonstop4h 53mCopa Airlines
Tue 1/201:15 amVVI - PTY
Nonstop4h 49mCopa Airlines
Deal found 9/13$625
This Copa Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/249:43 pmPTY - VVI
Nonstop4h 53mCopa Airlines
Sat 1/31:15 amVVI - PTY
Nonstop4h 49mCopa Airlines
Deal found 9/13$630
This Avianca deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/212:55 pmPTY - VVI
1 stop10h 40mAvianca
Tue 1/203:40 amVVI - PTY
1 stop11h 20mAvianca
Deal found 9/13$633
This Copa Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/114:40 pmPTY - VVI
Nonstop5h 06mCopa Airlines
Sat 1/31:15 amVVI - PTY
Nonstop4h 49mCopa Airlines
Deal found 9/13$651
This Copa Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/179:43 pmPTY - VVI
Nonstop4h 53mCopa Airlines
Thu 12/251:09 amVVI - PTY
Nonstop4h 55mCopa Airlines
Deal found 9/12$699

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Panama City to Santa Cruz de la Sierra that are best for you.

Fly from

Panama City

Fly to

Santa Cruz de la Sierra

Route

Depart

Return

Price

Panama CitySanta Cruz de la Sierra

PTY - VVI

PTYVVI

Panama City Tocumen Intl

Mon 11/3

9:43 pm-3:36 am

Nonstop4h 53m

Santa Cruz de la Sierra Viru Viru Intl

Fri 11/7

1:09 am-5:04 am

Nonstop4h 55m

$467

Panama CitySanta Cruz de la Sierra

PTY - VVI

PTYVVI

Panama City Tocumen Intl

Mon 11/3

4:40 pm-10:46 pm

Nonstop5h 06m

Santa Cruz de la Sierra Viru Viru Intl

Thu 11/6

1:09 am-5:04 am

Nonstop4h 55m

$467

Panama CitySanta Cruz de la Sierra

PTY - VVI

PTYVVI

Panama City Tocumen Intl

Tue 12/2

4:40 pm-10:46 pm

Nonstop5h 06m

Santa Cruz de la Sierra Viru Viru Intl

Sat 12/6

1:09 am-5:04 am

Nonstop4h 55m

$467

Panama CitySanta Cruz de la Sierra

PTY - VVI

PTYVVI

Panama City Tocumen Intl

Fri 10/31

9:43 pm-3:36 am

Nonstop4h 53m

Santa Cruz de la Sierra Viru Viru Intl

Tue 11/4

1:09 am-5:04 am

Nonstop4h 55m

$467

Panama CitySanta Cruz de la Sierra

PTY - VVI

PTYVVI

Panama City Tocumen Intl

Wed 11/5

4:40 pm-10:46 pm

Nonstop5h 06m

Santa Cruz de la Sierra Viru Viru Intl

Tue 11/11

11:40 am-3:35 pm

Nonstop4h 55m

$467

Panama CitySanta Cruz de la Sierra

PTY - VVI

PTYVVI

Panama City Tocumen Intl

Mon 10/13

9:43 pm-3:36 am

Nonstop4h 53m

Santa Cruz de la Sierra Viru Viru Intl

Tue 10/21

1:09 am-5:04 am

Nonstop4h 55m

$467

Panama CitySanta Cruz de la Sierra

PTY - VVI

PTYVVI

Panama City Tocumen Intl

Sun 11/30

9:43 pm-3:36 am

Nonstop4h 53m

Santa Cruz de la Sierra Viru Viru Intl

Tue 12/23

1:09 am-5:04 am

Nonstop4h 55m

$530

Panama CitySanta Cruz de la Sierra

PTY - VVI

PTYVVI

Panama City Tocumen Intl

Wed 12/10

9:45 am-2:35 am

1 stop15h 50m

Santa Cruz de la Sierra Viru Viru Intl

Tue 12/23

3:40 am-2:00 pm

1 stop11h 20m

$566

Panama CitySanta Cruz de la Sierra

PTY - VVI

PTYVVI

Panama City Tocumen Intl

Wed 11/5

2:55 pm-2:35 am

1 stop10h 40m

$289

Panama CitySanta Cruz de la Sierra

PTY - VVI

PTYVVI

Panama City Tocumen Intl

Wed 11/5

2:55 pm-8:30 am

2 stops16h 35m

$409

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/13

Showing 1-10 of 13 results
1
2

Best time to book a flight from Panama City to Santa Cruz de la Sierra

Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Santa Cruz de la Sierra

How far ahead should I book a flight from Panama City to Santa Cruz de la Sierra?

Use this chart to determine the optimal time to book a round-trip flight from Panama City to Santa Cruz de la Sierra. Price data was last updated on September 12, 2025.

The price you pay for your flight from Panama City to Santa Cruz de la Sierra may vary depending on when you book. For the best chance of a lower fare, look to book 40 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Panama City to Santa Cruz de la Sierra?

Currently, October is the cheapest month in which you can book a flight from Panama City to Santa Cruz de la Sierra (average of $597). Flying from Panama City to Santa Cruz de la Sierra in December is currently the most expensive (average of $822). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to VVI?

Find hourly flight availability from Panama City to Santa Cruz de la Sierra. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 15, 2025.

It’s optimal to fly from Panama City to Santa Cruz de la Sierra in the morning. By choosing this option you can save up to 4% on the cost of your flight, compared to a flight at noon.

Reviews of airlines servicing Santa Cruz de la Sierra

Get insights into the airlines that provide service to Santa Cruz de la Sierra. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Cruz de la Sierra. Reviews last updated September 15, 2025.
See what other customers who have flown with Copa Airlines and Avianca from Panama City to Santa Cruz de la Sierra have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,531 reviews

Boarding

7.8

Comfort

7.4

Food

6.8

Overall

7.6

Crew

8.1

Entertainment

6.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Copa Airlines
7.6
Good
1,531 reviews
Copa Airlines
7.6
Good
1,531 reviews

Boarding

7.8

Comfort

7.4

Food

6.8

Overall

7.6

Crew

8.1

Entertainment

6.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Avianca
6.7
Okay
2,435 reviews
Copa Airlines
7.6
Good
1,531 reviews

Boarding

7.8

Comfort

7.4

Food

6.8

Overall

7.6

Crew

8.1

Entertainment

6.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip

Related info for your journey

Find useful and relevant information for your journey from Panama City to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Panama City to Santa Cruz de la Sierra?

    To fly from Panama City to Santa Cruz de la Sierra, you need to book a flight from Tocumen Intl (PTY) to Viru Viru Intl (VVI). Nonstop flights to Santa Cruz de la Sierra Viru Viru Intl from Panama City Tocumen Intl take 15h 50m on average. When it comes time to book airfare, you have a few options: there are 2 outbound flights from Tocumen Intl to Viru Viru Intl offered by 2 different airlines.

  • How long is the flight from Panama City to Santa Cruz de la Sierra?

    For as low as $467, Copa Airlines can have you in Santa Cruz de la Sierra from Panama City in 4h 53m. Panama City and Santa Cruz de la Sierra are separated by a distance of 2152 mi. Generally, flights for this route are nonstop.

  • What are the cheapest airlines flying from Panama City to Santa Cruz de la Sierra round-trip?

    Our cheapest airline available from Panama City to Santa Cruz de la Sierra is Avianca. Our recent data shows that you can find tickets from as low as $321 on this airline. An additional option worth looking into is Copa Airlines, starting at $405. Avianca is priced at 37% lower than the current average price of a flight leaving 3 months from now.

  • What are the most reliable airlines from Panama City to Santa Cruz de la Sierra?

    The top 3 most reliable airlines when flying from Panama City to Santa Cruz de la Sierra are United Airlines (93%), BoA (90%) and Copa Airlines (85%).

  • Can I find deals for flights from Panama City to Santa Cruz de la Sierra that include hotel bookings?

    Yes. In addition to deals on Panama City to Santa Cruz de la Sierra flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Santa Cruz de la Sierra?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Santa Cruz de la Sierra.

  • Can I find deals for business class flights from Panama City to Santa Cruz de la Sierra?

    Yes. Cheapflights offers flight deals from Panama City to Santa Cruz de la Sierra by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Santa Cruz de la Sierra?

    Currently, October is the cheapest month in which you can book a flight from Panama City to Santa Cruz de la Sierra (average of $597). Flying from Panama City to Santa Cruz de la Sierra in December is currently the most expensive (average of $822). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Complete your trip

Complete your trip to Santa Cruz de la Sierra by adding a car rental and/or hotel reservation to your travel itinerary.
Santa Cruz de la Sierra car rentals
Santa Cruz de la Sierra Viru Viru Intl Airport car rentals
La Paz car rentals
Cochabamba car rentals
Tarija car rentals

Top 2 airlines flying from Panama City to Santa Cruz de la Sierra

Discover the top 2 airlines that operate flights from Panama City to Santa Cruz de la Sierra. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$321Average$363FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$405Average$574FlexibilityNo cancel feeOn-time70%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.