What is the cheapest day to fly from Panama City to Santa Cruz de la Sierra?

Travelers seeking maximum savings on their Panama City to Santa Cruz de la Sierra flight should consider departing on Friday afternoons when fares are most often at their lowest. Thursday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

What is the cheapest day to fly round-trip from Panama City to Santa Cruz de la Sierra?

Departing on a Thursday is a good option for securing a great price. You can expect to save up to 24% when planning your travel around this day of the week.

How far in advance should I book a flight from Panama City to Santa Cruz de la Sierra?

Travelers have found it’s best to book a flight 41 days in advance to save up to 108% compared to booking the same week of travel. As your travel date approaches, the cost of this flight route may potentially increase. While opting to book 41 days out may not be an option for all, there are still additional ways to secure a deal in the near future. You might find a flight from Panama City to Santa Cruz de la Sierra 1-2 weeks in advance for as low as $335, or $376 for flights within the next 24 hours.

What is the cheapest month to fly from Panama City to Santa Cruz de la Sierra?

April can be a great time to fly to Santa Cruz de la Sierra from Panama City with a flight ticket averaging about $484. Cheapflights users have found deals in the month of April for as cheap as $170. The most expensive prices can be found in the month of July.

What airports do I use to fly from Panama City to Santa Cruz de la Sierra?

To fly from Panama City to Santa Cruz de la Sierra, you need to book a flight from Tocumen Intl (PTY) to Viru Viru Intl (VVI). Nonstop flights to Santa Cruz de la Sierra Viru Viru Intl from Panama City Tocumen Intl take 7h 25m on average. When it comes time to book airfare, you have a few options: there is 1 outbound flight from Tocumen Intl to Viru Viru Intl offered by 2 different airlines.

How can I find direct flights from Panama City to Santa Cruz de la Sierra?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Santa Cruz de la Sierra.

Can I find deals for business class flights from Panama City to Santa Cruz de la Sierra?

Yes. Cheapflights offers flight deals from Panama City to Santa Cruz de la Sierra by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$563+ Flights from Panama City to Santa Cruz de la Sierra

Q: How much does it cost to fly round-trip from Panama City to Santa Cruz de la Sierra?

Airfare is typical for this route at the moment. Panama City to Santa Cruz de la Sierra flights typically cost between $360 and $614 in September. The cheapest round-trip price found within the last 3 days was $563 on Avianca (Sep 23-Sep 28).

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1. Tell us where you want to go

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Cheapflights Tip: The best prices from Panama City Tocumen Intl to Santa Cruz de la Sierra Viru Viru Intl are usually found in April or September, booked 40 days in advance, depart on a Wednesday or Monday and return on a Monday

Cheap flight deals from Panama City to Santa Cruz de la Sierra

Round-trip from	$563 (Avianca)
Popular in	July
Cheapest in	April
Average price	$620

From Panama City Tocumen Intl to Santa Cruz de la Sierra Viru Viru Intl

Search Deals

Highest demand for flights based on searches. 10% potential increase in price ($57 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 2% potential price decrease ($13 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in July 2025

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Find flight deals from Panama City to Santa Cruz de la Sierra

Cheapest flights from Panama City to Santa Cruz de la Sierra
Explore the most affordable flight options available from Panama City to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 31, 2025.

Tue 9/2310:05 pmPTY - VVI

1 stop26h 45mAvianca

Sun 9/282:50 amVVI - PTY

1 stop14h 40mAvianca

Deal found 7/31

$563

Mon 9/159:43 pmPTY - VVI

Nonstop4h 53mCopa Airlines

Sun 10/191:09 amVVI - PTY

Nonstop4h 55mCopa Airlines

Deal found 7/31

$593

Thu 8/283:20 amPTY - VVI

2 stops28h 30mMultiple Airlines

Thu 9/42:50 amVVI - PTY

1 stop22h 55mMultiple Airlines

Deal found 7/30

$777

Best flights from Panama City to Santa Cruz de la Sierra
Discover carefully curated flight deals from Panama City to Santa Cruz de la Sierra that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 31, 2025.

Tue 9/2310:05 pmPTY - VVI

1 stop26h 45mAvianca

Sun 9/282:50 amVVI - PTY

1 stop14h 40mAvianca

Deal found 7/31

$563

Mon 9/159:43 pmPTY - VVI

Nonstop4h 53mCopa Airlines

Sun 10/191:09 amVVI - PTY

Nonstop4h 55mCopa Airlines

Deal found 7/31

$593

Thu 8/283:20 amPTY - VVI

2 stops28h 30mMultiple Airlines

Thu 9/42:50 amVVI - PTY

1 stop22h 55mMultiple Airlines

Deal found 7/30

$777

Last-minute flights from Panama City to Santa Cruz de la Sierra
Discover last-minute flight deals from Panama City to Santa Cruz de la Sierra. Data last updated July 31, 2025 and is based on user searches.

Sat 8/95:25 pmPTY - VVI

1 stop7h 25mAvianca

Thu 8/282:50 amVVI - PTY

1 stop8h 20mAvianca

Deal found 7/30

$758

Sun 8/104:17 pmPTY - VVI

Nonstop5h 02mCopa Airlines

Sat 8/161:09 amVVI - PTY

Nonstop4h 55mCopa Airlines

Deal found 7/31

$721

Tue 8/123:20 amPTY - VVI

1 stop21h 30mAvianca

Tue 8/262:50 amVVI - PTY

1 stop19h 20mAvianca

Deal found 7/31

$566

Sat 8/234:17 pmPTY - VVI

Nonstop5h 02mCopa Airlines

Tue 8/2612:15 pmVVI - PTY

Nonstop4h 55mCopa Airlines

Deal found 7/31

$635

Thu 8/283:20 amPTY - VVI

2 stops28h 30mMultiple Airlines

Thu 9/42:50 amVVI - PTY

1 stop22h 55mMultiple Airlines

Deal found 7/30

$777

One-way flights from Panama City to Santa Cruz de la Sierra
Search for one-way flight options from Panama City to Santa Cruz de la Sierra. Find affordable one-way fares based on user searches. Data last updated July 31, 2025.

Sat 10/184:17 pmPTY - VVI

Nonstop5h 00mCopa Airlines

Deal found 7/31

$671

Cheapflights Fare Finder

Use the filters below to find and compare flights from Panama City to Santa Cruz de la Sierra that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CitySanta Cruz de la Sierra

PTY - VVI

PTYVVI

Panama City Tocumen Intl

Tue 9/23

10:05 pm-1:50 am

1 stop26h 45m

Santa Cruz de la Sierra Viru Viru Intl

Sun 9/28

2:50 am-4:30 pm

1 stop14h 40m

$563

Panama CitySanta Cruz de la Sierra

PTY - VVI

PTYVVI

Panama City Tocumen Intl

Mon 9/15

9:43 pm-3:36 am

Nonstop4h 53m

Santa Cruz de la Sierra Viru Viru Intl

Sun 10/19

1:09 am-5:04 am

Nonstop4h 55m

$593

Panama CitySanta Cruz de la Sierra

PTY - VVI

PTYVVI

Panama City Tocumen Intl

Thu 8/28

3:20 am-8:50 am

2 stops28h 30m

Santa Cruz de la Sierra Viru Viru Intl

Thu 9/4

2:50 am-12:45 am

1 stop22h 55m

$777

Panama CitySanta Cruz de la Sierra

PTY - VVI

PTYVVI

Panama City Tocumen Intl

Sat 10/18

4:17 pm-10:17 pm

Nonstop5h 00m

$671

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/31

Best time to book a flight from Panama City to Santa Cruz de la Sierra

Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Panama City with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Santa Cruz de la Sierra

How far ahead should I book a flight from Panama City to Santa Cruz de la Sierra?

The price you pay for your flight from Panama City to Santa Cruz de la Sierra may vary depending on when you book. For the best chance of a lower fare, look to book 40 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Panama City to Santa Cruz de la Sierra?

Currently, October is the cheapest month in which you can book a flight from Panama City to Santa Cruz de la Sierra (average of $597). Flying from Panama City to Santa Cruz de la Sierra in December is currently the most expensive (average of $822). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to VVI?

It’s optimal to fly from Panama City to Santa Cruz de la Sierra in the morning. By choosing this option you can save up to 4% on the cost of your flight, compared to a flight at noon.

How much does it cost to fly round-trip from Panama City to Santa Cruz de la Sierra?

Reviews of airlines servicing Santa Cruz de la Sierra

See what other customers who have flown with Copa Airlines and Avianca from Panama City to Santa Cruz de la Sierra have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Copa Airlines

7.5

Good

1,493 reviews

Reviews

1 / 20

4.0

Okay

Paul,Jun 2025

PTY - MIA

The boarding process was terrible. No one followed the group numbers. Everyone got up and stood in the tiles upon landing. People kept getting up during the meal and beverage service to go the bathrooms, the crew had to go back and forth in the isles, the service took forever.

Copa Airlines

7.5

Good

1,493 reviews

Copa Airlines

7.5

Good

1,493 reviews

Reviews

1 / 20

4.0

Okay

Paul,Jun 2025

PTY - MIA

Avianca

6.7

Okay

2,388 reviews

Copa Airlines

7.5

Good

1,493 reviews

Reviews

1 / 20

4.0

Okay

Paul,Jun 2025

PTY - MIA

Related info for your journey

What airports do I use to fly from Panama City to Santa Cruz de la Sierra?
To fly from Panama City to Santa Cruz de la Sierra, you need to book a flight from Tocumen Intl (PTY) to Viru Viru Intl (VVI). Nonstop flights to Santa Cruz de la Sierra Viru Viru Intl from Panama City Tocumen Intl take 7h 25m on average. When it comes time to book airfare, you have a few options: there is 1 outbound flight from Tocumen Intl to Viru Viru Intl offered by 2 different airlines.
What are the cheapest airlines flying from Panama City to Santa Cruz de la Sierra round-trip?
Our cheapest airline available from Panama City to Santa Cruz de la Sierra is Avianca. Our recent data shows that you can find tickets from as low as $563 on this airline. An additional option worth looking into is Copa Airlines, starting at $593.
Can I find deals for flights from Panama City to Santa Cruz de la Sierra that include hotel bookings?
Yes. In addition to deals on Panama City to Santa Cruz de la Sierra flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Panama City to Santa Cruz de la Sierra?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Santa Cruz de la Sierra.
Can I find deals for business class flights from Panama City to Santa Cruz de la Sierra?
Yes. Cheapflights offers flight deals from Panama City to Santa Cruz de la Sierra by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Panama City to Santa Cruz de la Sierra?
Currently, October is the cheapest month in which you can book a flight from Panama City to Santa Cruz de la Sierra (average of $597). Flying from Panama City to Santa Cruz de la Sierra in December is currently the most expensive (average of $822). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Complete your trip

Santa Cruz de la Sierra car rentals

Santa Cruz de la Sierra Viru Viru Intl Airport car rentals

Cochabamba car rentals

Top 2 airlines flying from Panama City to Santa Cruz de la Sierra

Airline	Cheapest	Average	Flexibility	On-time
Avianca	Cheapest$321	Average$358	FlexibilityNo cancel fee	On-time71%
Copa Airlines	Cheapest$405	Average$573	FlexibilityNo cancel fee	On-time70%

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$563+ Cheap flights from Panama City (PTY) to Santa Cruz de la Sierra (VVI)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/23. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Panama City to Santa Cruz de la Sierra with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from Panama City Tocumen Intl to Santa Cruz de la Sierra Viru Viru Intl are usually found in April or September, booked 40 days in advance, depart on a Wednesday or Monday and return on a Monday

Cheap flight deals from Panama City to Santa Cruz de la Sierra

Round-trip from

Popular in

Cheapest in

Average price

Find flight deals from Panama City to Santa Cruz de la Sierra

Cheapest flights from Panama City to Santa Cruz de la SierraExplore the most affordable flight options available from Panama City to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 31, 2025.

Explore the most affordable flight options available from Panama City to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 31, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Panama City to Santa Cruz de la Sierra that are best for you.

Best time to book a flight from Panama City to Santa Cruz de la Sierra

Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Panama City with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Santa Cruz de la Sierra

How far ahead should I book a flight from Panama City to Santa Cruz de la Sierra?

Use this chart to determine the optimal time to book a round-trip flight from Panama City to Santa Cruz de la Sierra. Price data was last updated on July 25, 2025.

What is the cheapest month to book a flight from Panama City to Santa Cruz de la Sierra?

What is the cheapest time of day to fly from PTY to VVI?

Find hourly flight availability from Panama City to Santa Cruz de la Sierra. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 31, 2025.

How much does it cost to fly round-trip from Panama City to Santa Cruz de la Sierra?

Reviews of airlines servicing Santa Cruz de la Sierra

See what other customers who have flown with Copa Airlines and Avianca from Panama City to Santa Cruz de la Sierra have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airports do I use to fly from Panama City to Santa Cruz de la Sierra?

What are the cheapest airlines flying from Panama City to Santa Cruz de la Sierra round-trip?

Can I find deals for flights from Panama City to Santa Cruz de la Sierra that include hotel bookings?

How can I find direct flights from Panama City to Santa Cruz de la Sierra?

Can I find deals for business class flights from Panama City to Santa Cruz de la Sierra?

What is the cheapest month to book a flight from Panama City to Santa Cruz de la Sierra?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Complete your trip

Complete your trip to Santa Cruz de la Sierra by adding a car rental and/or hotel reservation to your travel itinerary.

Top 2 airlines flying from Panama City to Santa Cruz de la Sierra

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Book with Flexibility

Travel Smart

Cheapest flights from Panama City to Santa Cruz de la Sierra
Explore the most affordable flight options available from Panama City to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 31, 2025.