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Santa Cruz de la Sierra

$512+ Cheap flights from Panama City (PTY) to Santa Cruz de la Sierra (VVI)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/15. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — VVI
Jan 14 — Jan 211
Wed 1/14
Wed 1/21
1 adult, Economy
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Find cheap flights from Panama City to Santa Cruz de la Sierra with Cheapflights

1. Tell us where you want to go

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2. Select your favorite providers

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Cheapflights Tip: The best prices from Panama City Tocumen Intl to Santa Cruz de la Sierra Viru Viru Intl are usually found in May or April, booked 65 days in advance, depart on a Wednesday or Tuesday and return on a Saturday

Cheap flight deals from Panama City to Santa Cruz de la Sierra

Cheapest flights from Panama City to Santa Cruz de la Sierra
Explore the most affordable flight options available from Panama City to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 15, 2025.

This Copa Airlines deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/284:40 pmPTY - VVI
Nonstop5h 06mCopa Airlines
Thu 1/11:15 amVVI - PTY
Nonstop4h 49mCopa Airlines
Deal found 12/13$721
This Avianca deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/189:45 amPTY - VVI
1 stop15h 50mAvianca
Fri 1/93:40 amVVI - PTY
1 stop14h 15mAvianca
Deal found 12/15$889
This Copa Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/164:40 pmPTY - VVI
Nonstop5h 06mCopa Airlines
Tue 12/2311:40 amVVI - PTY
Nonstop4h 55mCopa Airlines
Deal found 12/15$914
This Copa Airlines deal was found by Cheapflights users on 12/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/134:40 pmPTY - VVI
Nonstop5h 06mCopa Airlines
Sun 12/141:09 amVVI - PTY
Nonstop4h 55mCopa Airlines
Deal found 12/12$946
This Copa Airlines deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/184:40 pmPTY - VVI
Nonstop5h 06mCopa Airlines
Fri 1/91:15 amVVI - PTY
Nonstop4h 49mCopa Airlines
Deal found 12/14$1,068
This Copa Airlines deal was found by Cheapflights users on 12/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/194:40 pmPTY - VVI
Nonstop5h 06mCopa Airlines
Sat 1/31:15 amVVI - PTY
Nonstop4h 49mCopa Airlines
Deal found 12/12$1,356

Find flight deals from Panama City to Santa Cruz de la Sierra

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Santa Cruz de la Sierra (VVI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 15, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$512
(Avianca)

Popular in

January

Cheapest in

May

Average price

$641
Provider with most accurate pricing for Panama City Tocumen Intl-Santa Cruz de la Sierra Viru Viru Intl flight deals.
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Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Santa Cruz de la Sierra Viru Viru Intl flights.
Search Deals
From Panama City Tocumen Intl to Santa Cruz de la Sierra Viru Viru Intl
Search Deals
Highest demand for flights based on searches. 17% potential increase in price ($116 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($25 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 15, 2025.
Use the filters below to find and compare flights from Panama City to Santa Cruz de la Sierra that are best for you.

Fly from

Panama City

Fly to

Santa Cruz de la Sierra

Route

Depart

Return

Price

Panama CitySanta Cruz de la Sierra

PTY - VVI

PTYVVI

Panama City Tocumen Intl

Thu 1/15

9:45 am-2:35 am

1 stop15h 50m

Santa Cruz de la Sierra Viru Viru Intl

Wed 1/21

3:40 am-2:00 pm

1 stop11h 20m

$512

Panama CitySanta Cruz de la Sierra

PTY - VVI

PTYVVI

Panama City Tocumen Intl

Mon 3/16

4:40 pm-10:50 pm

Nonstop5h 10m

Santa Cruz de la Sierra Viru Viru Intl

Fri 3/20

1:14 am-5:04 am

Nonstop4h 50m

$534

Panama CitySanta Cruz de la Sierra

PTY - VVI

PTYVVI

Panama City Tocumen Intl

Mon 3/2

9:43 pm-3:38 am

Nonstop4h 55m

Santa Cruz de la Sierra Viru Viru Intl

Thu 3/5

1:14 am-5:04 am

Nonstop4h 50m

$534

Panama CitySanta Cruz de la Sierra

PTY - VVI

PTYVVI

Panama City Tocumen Intl

Mon 4/27

9:43 pm-3:40 am

Nonstop4h 57m

Santa Cruz de la Sierra Viru Viru Intl

Sat 5/2

1:12 am-5:04 am

Nonstop4h 52m

$534

Panama CitySanta Cruz de la Sierra

PTY - VVI

PTYVVI

Panama City Tocumen Intl

Tue 4/28

4:40 pm-10:42 pm

Nonstop5h 02m

Santa Cruz de la Sierra Viru Viru Intl

Sat 5/2

1:12 am-5:04 am

Nonstop4h 52m

$534

Panama CitySanta Cruz de la Sierra

PTY - VVI

PTYVVI

Panama City Tocumen Intl

Mon 5/18

9:43 pm-3:31 am

Nonstop4h 48m

Santa Cruz de la Sierra Viru Viru Intl

Mon 5/25

11:47 am-3:39 pm

Nonstop4h 52m

$534

Panama CitySanta Cruz de la Sierra

PTY - VVI

PTYVVI

Panama City Tocumen Intl

Fri 3/13

5:50 pm-2:35 am

1 stop7h 45m

Santa Cruz de la Sierra Viru Viru Intl

Thu 3/19

3:40 am-2:00 pm

1 stop11h 20m

$552

Panama CitySanta Cruz de la Sierra

PTY - VVI

PTYVVI

Panama City Tocumen Intl

Fri 1/16

4:40 pm-10:50 pm

Nonstop5h 10m

Santa Cruz de la Sierra Viru Viru Intl

Sun 1/18

1:15 am-5:04 am

Nonstop4h 49m

$566

Panama CitySanta Cruz de la Sierra

PTY - VVI

PTYVVI

Panama City Tocumen Intl

Tue 1/13

4:40 pm-10:50 pm

Nonstop5h 10m

Santa Cruz de la Sierra Viru Viru Intl

Mon 1/19

1:15 am-5:04 am

Nonstop4h 49m

$566

Panama CitySanta Cruz de la Sierra

PTY - VVI

PTYVVI

Panama City Tocumen Intl

Mon 1/12

4:40 pm-10:50 pm

Nonstop5h 10m

Santa Cruz de la Sierra Viru Viru Intl

Tue 1/27

1:15 am-5:04 am

Nonstop4h 49m

$568

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/13

Showing 1-10 of 15 results
1
2

Compare providers for flights from Panama City to Santa Cruz de la Sierra

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Santa Cruz de la Sierra in December.
ProviderPrice AccuracyTrust Score*
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City-Santa Cruz de la Sierra flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Panama City-Santa Cruz de la Sierra flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Panama City-Santa Cruz de la Sierra flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City-Santa Cruz de la Sierra flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Santa Cruz de la Sierra flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Santa Cruz de la Sierra

Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Santa Cruz de la Sierra

How far ahead should I book a flight from Panama City to Santa Cruz de la Sierra?

Use this chart to determine the optimal time to book a round-trip flight from Panama City to Santa Cruz de la Sierra. Price data was last updated on December 12, 2025.

The price you pay for your flight from Panama City to Santa Cruz de la Sierra may vary depending on when you book. For the best chance of a lower fare, look to book 64 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Panama City to Santa Cruz de la Sierra?

Currently, April is the cheapest month in which you can book a flight from Panama City to Santa Cruz de la Sierra (average of $172). Flying from Panama City to Santa Cruz de la Sierra in December is currently the most expensive (average of $563). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to VVI?

Find hourly flight availability from Panama City to Santa Cruz de la Sierra. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 15, 2025.

When flying from Panama City to Santa Cruz de la Sierra, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing Santa Cruz de la Sierra

Get insights into the airlines that provide service to Santa Cruz de la Sierra. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Cruz de la Sierra. Reviews last updated December 15, 2025.
See what other customers who have flown with Copa Airlines and Avianca from Panama City to Santa Cruz de la Sierra have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,557 reviews

Entertainment

6.8

Boarding

7.8

Comfort

7.4

Food

6.8

Overall

7.6

Crew

8.1

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Copa Airlines
7.6
Good
1,557 reviews
Copa Airlines
7.6
Good
1,557 reviews

Entertainment

6.8

Boarding

7.8

Comfort

7.4

Food

6.8

Overall

7.6

Crew

8.1

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Avianca
6.6
Okay
2,485 reviews
Copa Airlines
7.6
Good
1,557 reviews

Entertainment

6.8

Boarding

7.8

Comfort

7.4

Food

6.8

Overall

7.6

Crew

8.1

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip

Related info for your journey

Find useful and relevant information for your journey from Panama City to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Panama City to Santa Cruz de la Sierra?

    To fly from Panama City to Santa Cruz de la Sierra, you need to book a flight from Tocumen Intl (PTY) to Viru Viru Intl (VVI). Nonstop flights to Santa Cruz de la Sierra Viru Viru Intl from Panama City Tocumen Intl take 5h 06m on average. When it comes time to book airfare, you have a few options: there are 2 outbound flights from Tocumen Intl to Viru Viru Intl offered by 2 different airlines.

  • How long is the flight from Panama City to Santa Cruz de la Sierra?

    For as low as $534, Avianca can have you in Santa Cruz de la Sierra from Panama City in 4h 55m. Panama City and Santa Cruz de la Sierra are separated by a distance of 2152 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Panama City to Santa Cruz de la Sierra round-trip?

    Our cheapest airline available from Panama City to Santa Cruz de la Sierra is Avianca. Our recent data shows that you can find tickets from as low as $263 on this airline. An additional option worth looking into is Copa Airlines, starting at $279. Avianca is priced at 53% lower than the current average price of a flight leaving 3 months from now.

  • What are the most reliable airlines from Panama City to Santa Cruz de la Sierra?

    The top 3 most reliable airlines when flying from Panama City to Santa Cruz de la Sierra are Copa Airlines (86%), United Airlines (85%) and BoA (63%).

  • Can I find deals for flights from Panama City to Santa Cruz de la Sierra that include hotel bookings?

    Yes. In addition to deals on Panama City to Santa Cruz de la Sierra flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Santa Cruz de la Sierra?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Santa Cruz de la Sierra.

  • Can I find deals for business class flights from Panama City to Santa Cruz de la Sierra?

    Yes. Cheapflights offers flight deals from Panama City to Santa Cruz de la Sierra by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Santa Cruz de la Sierra?

    Currently, April is the cheapest month in which you can book a flight from Panama City to Santa Cruz de la Sierra (average of $172). Flying from Panama City to Santa Cruz de la Sierra in December is currently the most expensive (average of $563). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Complete your trip

Complete your trip to Santa Cruz de la Sierra by adding a car rental and/or hotel reservation to your travel itinerary.
Santa Cruz de la Sierra car rentals
Santa Cruz de la Sierra Viru Viru Intl Airport car rentals
La Paz car rentals
Cochabamba car rentals
Tarija car rentals

Top 2 airlines flying from Panama City to Santa Cruz de la Sierra

Discover the top 2 airlines that operate flights from Panama City to Santa Cruz de la Sierra. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$321Average$363FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$356Average$619FlexibilityNo cancel feeOn-time70%

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