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$216+ Cheap flights from Santo Domingo (SDQ) to San Francisco (SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/14. Fares are subject to change and may not be available on all flights or dates of travel.
SDQ — SFO
Nov 27 — Dec 41
Thu 11/27
Thu 12/4
1 adult, Economy
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Cheap flight deals from Santo Domingo to San Francisco

Discover tips and strategies to find the most affordable flight options for your journey from Santo Domingo (SDQ) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 28, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$488
(Expedia)

One-way from

$216
(Kiwi.com)

Popular in

February

Cheapest in

September

Average price

$544
Provider with most accurate pricing for Santo Domingo Las Americas-San Francisco flight deals.
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Provider most trusted by Cheapflights users for Santo Domingo Las Americas-San Francisco flights.
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From Santo Domingo Las Americas to San Francisco
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One-way flight from Santo Domingo Las Americas to San Francisco
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Highest demand for flights based on searches. 6% potential increase in price ($42 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($14 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Santo Domingo to San Francisco

Cheapest flights from Santo Domingo to San Francisco
Explore the most affordable flight options available from Santo Domingo to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 28, 2025.

This Expedia deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/1511:50 amSDQ - SFO
1 stop15h 41mJetBlue
Sat 11/297:00 amSFO - SDQ
1 stop27h 10mJetBlue
Deal found 10/26$488
This Trip.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/206:38 pmSDQ - SFO
1 stop18h 07mJetBlue
Wed 12/38:15 amSFO - SDQ
1 stop12h 40mJetBlue
Deal found 10/27$540
This Kiwi.com deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/116:10 amSDQ - SFO
2 stops43h 12mMultiple Airlines
Tue 11/1810:43 pmSFO - SDQ
1 stop13h 43mMultiple Airlines
Deal found 10/26$558
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/144:25 pmSDQ - SFO
2 stops32h 46mMultiple Airlines
Mon 12/159:59 pmSFO - SDQ
1 stop27h 26mMultiple Airlines
Deal found 10/27$561
This Expedia deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/113:27 pmSDQ - SFO
1 stop21h 58mJetBlue
Tue 11/187:00 amSFO - SDQ
1 stop14h 53mJetBlue
Deal found 10/26$569
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/186:10 amSDQ - SFO
2 stops35h 40mMultiple Airlines
Mon 12/159:59 pmSFO - SDQ
1 stop27h 26mMultiple Airlines
Deal found 10/28$599
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/56:10 amSDQ - SFO
1 stop14h 40mMultiple Airlines
Thu 12/117:00 amSFO - SDQ
1 stop13h 45mMultiple Airlines
Deal found 10/28$614
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/57:10 pmSDQ - SFO
2 stops30h 40mMultiple Airlines
Sun 12/1410:56 pmSFO - SDQ
1 stop26h 29mMultiple Airlines
Deal found 10/27$617

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santo Domingo to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 28, 2025.
Use the filters below to find and compare flights from Santo Domingo to San Francisco that are best for you.

Fly from

Santo Domingo

Fly to

San Francisco

Route

Depart

Return

Price

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Sat 11/15

11:50 am-11:31 pm

1 stop15h 41m

San Francisco

Sat 11/29

7:00 am-2:10 pm

1 stop27h 10m

$488

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Mon 2/9

5:45 pm-11:20 pm

2 stops33h 35m

San Francisco

Sun 2/15

1:20 pm-4:50 pm

2 stops23h 30m

$531

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Tue 11/11

6:10 am-9:22 pm

2 stops43h 12m

San Francisco

Tue 11/18

10:43 pm-4:26 pm

1 stop13h 43m

$558

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Mon 2/9

6:10 am-11:03 pm

2 stops20h 53m

San Francisco

Sun 2/15

8:00 am-5:25 am

1 stop17h 25m

$568

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Sun 2/1

3:25 pm-10:31 am

1 stop23h 06m

San Francisco

Sat 2/7

11:59 pm-2:39 pm

1 stop10h 40m

$580

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Mon 11/10

4:10 am-10:20 am

1 stop34h 10m

San Francisco

Tue 11/18

7:00 am-1:53 am

1 stop14h 53m

$584

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Tue 11/18

6:10 am-1:50 pm

2 stops35h 40m

San Francisco

Mon 12/15

9:59 pm-5:25 am

1 stop27h 26m

$599

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Sun 2/1

11:57 am-11:20 pm

1 stop15h 23m

San Francisco

Fri 2/6

12:42 am-6:05 pm

1 stop13h 23m

$606

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Thu 2/19

2:35 am-12:46 pm

1 stop14h 11m

San Francisco

Mon 2/23

10:40 pm-3:17 pm

1 stop12h 37m

$620

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Fri 11/14

4:25 pm-10:27 pm

3 stops34h 02m

$216

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/28

Showing 1-10 of 18 results
1
2

Compare providers for flights from Santo Domingo to San Francisco

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santo Domingo to San Francisco in October.
ProviderPrice AccuracyTrust Score*
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Santo Domingo-San Francisco flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Santo Domingo-San Francisco flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Santo Domingo-San Francisco flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Santo Domingo-San Francisco flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santo Domingo-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santo Domingo to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Santo Domingo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to San Francisco

What is the cheapest month to book a flight from Santo Domingo to San Francisco?

Currently, September is the cheapest month in which you can book a flight from Santo Domingo to San Francisco (average of $261). Flying from Santo Domingo to San Francisco in August is currently the most expensive (average of $714). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SDQ to SFO?

Find hourly flight availability from Santo Domingo to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 28, 2025.

It’s typically best to fly out from Santo Domingo to San Francisco in the evening. Doing so could potentially save you 66% on the flight price compared to flying at noon, which is usually more expensive.

Reviews of airlines servicing San Francisco

Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated October 28, 2025.
Peruse reviews from past customers who have flown with American Airlines and JetBlue from Santo Domingo to San Francisco to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,033 reviews

Comfort

7.2

Boarding

7.5

Crew

8.0

Food

6.4

Overall

7.2

Entertainment

6.9

Reviews

1 / 20
10.0
Excellent

Anonymous,Jan 2024

LHR - SAN

This was the best flight I have experienced in all the years I have been f doing this journey with BA. Flight, food and service A1. Well done BA.
American Airlines
7.2
Good
11,033 reviews
American Airlines
7.2
Good
11,033 reviews

Comfort

7.2

Boarding

7.5

Crew

8.0

Food

6.4

Overall

7.2

Entertainment

6.9

Reviews

1 / 20
10.0
Excellent

Anonymous,Jan 2024

LHR - SAN

This was the best flight I have experienced in all the years I have been f doing this journey with BA. Flight, food and service A1. Well done BA.
JetBlue
7.2
Good
2,907 reviews
American Airlines
7.2
Good
11,033 reviews

Comfort

7.2

Boarding

7.5

Crew

8.0

Food

6.4

Overall

7.2

Entertainment

6.9

Reviews

1 / 20
10.0
Excellent

Anonymous,Jan 2024

LHR - SAN

This was the best flight I have experienced in all the years I have been f doing this journey with BA. Flight, food and service A1. Well done BA.

Related info for your journey

Find useful and relevant information for your journey from Santo Domingo to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Santo Domingo to San Francisco?

    A quick flight from Santo Domingo to San Francisco can take about 15h 41m. JetBlue provides one of the quickest options available for as low as $488. Santo Domingo and San Francisco are separated by a distance of 3424 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Santo Domingo to San Francisco round-trip?

    Our cheapest airline available from Santo Domingo to San Francisco is JetBlue. Our recent data shows that you can find tickets from as low as $486 on this airline. An additional option worth looking into is American Airlines, starting at $689. JetBlue is currently priced 25% below the average price you’ll pay for this route.

  • Can I find deals for flights from Santo Domingo to San Francisco that include hotel bookings?

    Yes. In addition to deals on Santo Domingo to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santo Domingo to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to San Francisco.

  • Can I find deals for business class flights from Santo Domingo to San Francisco?

    Yes. Cheapflights offers flight deals from Santo Domingo to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santo Domingo to San Francisco?

    Currently, September is the cheapest month in which you can book a flight from Santo Domingo to San Francisco (average of $261). Flying from Santo Domingo to San Francisco in August is currently the most expensive (average of $714). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Roseville
South San Francisco
Santa Cruz
Livermore
Turlock
Watsonville
Sunnyvale
Santa Clara
Antioch
Manteca
Vallejo
Hollister
Vacaville
San Bruno
Foster City
Redwood City
Union City
Fairfield
Burlingame
Lodi

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Santo Domingo to San Francisco

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Top 2 airlines flying from Santo Domingo to San Francisco

Discover the top 2 airlines that operate flights from Santo Domingo to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
JetBlueCheapest$486Average$595FlexibilityNo cancel feeOn-time62%
American AirlinesCheapest$689Average$790FlexibilityNo cancel feeOn-time71%

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