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$245+ Cheap flights from Santo Domingo (SDQ) to San Francisco (SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/7. Fares are subject to change and may not be available on all flights or dates of travel.
SDQ — SFO
Apr 9 — Apr 161
Thu 4/9
Thu 4/16
1 adult, Economy
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Cheap flight deals from Santo Domingo to San Francisco

Cheapest flights from Santo Domingo to San Francisco
Explore the most affordable flight options available from Santo Domingo to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 10, 2026.

This Expedia deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/14:08 pm
SDQ
-
SFO
1 stop30h 06m
Multiple Airlines
Wed 4/82:15 pm
SFO
-
SDQ
2 stops18h 35m
Multiple Airlines
Deal found 3/7$517
This Copa Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/2312:42 pm
SDQ
-
SFO
1 stop13h 58m
Copa Airlines
Sun 10/48:21 pm
SFO
-
SDQ
1 stop12h 20m
Copa Airlines
Deal found 3/6$519
This Frontier deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/310:15 am
SDQ
-
SFO
1 stop15h 37m
Frontier
Sun 8/98:20 pm
SFO
-
SDQ
2 stops11h 37m
Frontier
Deal found 3/5$523
This Orbitz deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/64:08 pm
SDQ
-
SFO
1 stop30h 11m
Multiple Airlines
Mon 4/1311:59 pm
SFO
-
SDQ
1 stop9h 29m
Multiple Airlines
Deal found 3/7$524
This Kiwi.com deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/207:10 pm
SDQ
-
SFO
1 stop29h 42m
Multiple Airlines
Mon 4/2710:38 pm
SFO
-
SDQ
2 stops20h 07m
Multiple Airlines
Deal found 3/6$553
This JetBlue deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/245:40 am
SDQ
-
SFO
1 stop16h 42m
JetBlue
Mon 4/2711:05 pm
SFO
-
SDQ
1 stop10h 23m
JetBlue
Deal found 3/8$555
This Travelocity deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/211:39 pm
SDQ
-
SFO
1 stop13h 17m
Multiple Airlines
Thu 5/1411:55 pm
SFO
-
SDQ
2 stops32h 55m
Multiple Airlines
Deal found 3/5$560
This Orbitz deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/210:20 am
SDQ
-
SFO
1 stop17h 38m
Multiple Airlines
Wed 4/82:15 pm
SFO
-
SDQ
2 stops24h 40m
Multiple Airlines
Deal found 3/9$565
This Kiwi.com deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/1510:19 am
SDQ
-
SFO
2 stops34h 15m
Multiple Airlines
Wed 4/227:40 am
SFO
-
SDQ
1 stop18h 49m
Multiple Airlines
Deal found 3/5$568

Find flight deals from Santo Domingo to San Francisco

Discover tips and strategies to find the most affordable flight options for your journey from Santo Domingo (SDQ) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 10, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$517
(Expedia)

One-way from

$245
(Kiwi.com)

Popular in

August

Cheapest in

June

Average price

$505
Provider with most accurate pricing for Santo Domingo Las Americas-San Francisco flight deals.
Search Deals
Provider most trusted by Cheapflights users for Santo Domingo Las Americas-San Francisco flights.
Search Deals
From Santo Domingo Las Americas to San Francisco
Search Deals
One-way flight from Santo Domingo Las Americas to San Francisco
Search Deals
Highest demand for flights based on searches. 9% potential increase in price ($58 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($15 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santo Domingo to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 10, 2026.
Use the filters below to find and compare flights from Santo Domingo to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Mon 4/20

7:10 pm-9:52 pm

1 stop29h 42m

San Francisco

Mon 4/27

10:38 pm-9:45 pm

2 stops20h 07m

$553
Quickest round-trip

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Fri 4/24

5:40 am-7:22 pm

1 stop16h 42m

San Francisco

Mon 4/27

11:05 pm-12:28 pm

1 stop10h 23m

$555

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Tue 4/21

1:39 pm-11:56 pm

1 stop13h 17m

San Francisco

Thu 5/14

11:55 pm-11:50 am

2 stops32h 55m

$560

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Tue 4/21

2:10 pm-11:55 pm

1 stop12h 45m

San Francisco

Tue 4/28

8:45 pm-2:50 pm

1 stop15h 05m

$584

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Wed 4/22

6:50 pm-12:50 pm

2 stops21h 00m

San Francisco

Wed 4/29

11:55 pm-5:55 pm

2 stops15h 00m

$593

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Wed 4/22

1:40 pm-11:56 pm

1 stop13h 16m

San Francisco

Wed 4/29

7:00 am-1:54 am

1 stop15h 54m

$596

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Tue 6/23

12:14 pm-12:36 am

1 stop15h 22m

San Francisco

Tue 7/14

7:45 am-5:55 pm

3 stops55h 10m

$608

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Thu 4/9

10:20 am-12:58 am

1 stop17h 38m

San Francisco

Sun 4/19

11:05 pm-12:28 pm

1 stop10h 23m

$608

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Thu 4/2

10:20 am-12:58 am

1 stop17h 38m

San Francisco

Wed 4/8

11:59 pm-6:31 pm

1 stop15h 32m

$610

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Sat 5/2

5:50 am-9:57 pm

1 stop19h 07m

San Francisco

Tue 5/5

10:50 pm-2:13 pm

1 stop12h 23m

$616

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/8

Showing 1-10 of 17 resultsSorted by cheapest first
1
2
  • Most accurate provider: When it comes to deals on Santo Domingo-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santo Domingo-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santo Domingo-San Francisco flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Santo Domingo-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santo Domingo-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santo Domingo to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Santo Domingo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to San Francisco

What is the cheapest month to book a flight from Santo Domingo to San Francisco?

Currently, March is the cheapest month in which you can book a flight from Santo Domingo to San Francisco (average of $218). Flying from Santo Domingo to San Francisco in August is currently the most expensive (average of $714). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing San Francisco

Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated March 10, 2026.
Peruse reviews from past customers who have flown with JetBlue from Santo Domingo to San Francisco to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
JetBlue
7.2
Good
2,900 reviews

Food

6.6

Comfort

7.5

Entertainment

7.2

Overall

7.2

Boarding

7.4

Crew

8.0

Reviews

1 / 20
6.0
Good

Anonymous,Mar 2026

FLL - ORH

I pay extra for an even more seat row 3, but the luggage area has no more spots so i have to place my luggage in row 10. This was totally un accepatable.
JetBlue
7.2
Good
2,900 reviews
JetBlue
7.2
Good
2,900 reviews

Food

6.6

Comfort

7.5

Entertainment

7.2

Overall

7.2

Boarding

7.4

Crew

8.0

Reviews

1 / 20
6.0
Good

Anonymous,Mar 2026

FLL - ORH

I pay extra for an even more seat row 3, but the luggage area has no more spots so i have to place my luggage in row 10. This was totally un accepatable.

Related info for your journey

Find useful and relevant information for your journey from Santo Domingo to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Santo Domingo to San Francisco?

    A quick flight from Santo Domingo to San Francisco can take about 16h 42m. JetBlue provides one of the quickest options available for as low as $555. Santo Domingo and San Francisco are separated by a distance of 3424 mi.

  • What is the cheapest airline to fly from Santo Domingo to San Francisco round-trip?

    Our cheapest airline available from Santo Domingo to San Francisco is JetBlue. Our recent data shows that you can find tickets from as low as $388 on this airline. JetBlue is currently priced 34% below the average price you’ll pay for this route.

  • What are the cheapest airlines to fly from Santo Domingo to San Francisco one-way?

    For one-way options, check prices for JetBlue. According to our data, you can fly for as low as $177. Users have also found prices from $274 and $317 on Copa Airlines and Delta, respectively.

  • Can I find deals for flights from Santo Domingo to San Francisco that include hotel bookings?

    Yes. In addition to deals on Santo Domingo to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santo Domingo to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to San Francisco.

  • Can I find deals for business class flights from Santo Domingo to San Francisco?

    Yes. Cheapflights offers flight deals from Santo Domingo to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santo Domingo to San Francisco?

    Currently, March is the cheapest month in which you can book a flight from Santo Domingo to San Francisco (average of $218). Flying from Santo Domingo to San Francisco in August is currently the most expensive (average of $714). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
South San Francisco
Santa Clara
Santa Cruz
Livermore
Roseville
Watsonville
San Bruno
Sunnyvale
Vacaville
Turlock
San Carlos
San Ramon
Redwood City
Daly City
Rancho Cordova
San Lorenzo
Davis
Hollister
Manteca
Union City

Browse thousands of different options on Cheapflights for your next trip

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Top airline flying from Santo Domingo to San Francisco

Discover the top airline that operate flights from Santo Domingo to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 10, 2026.
AirlineCheapestAverageFlexibilityOn-time
JetBlueCheapest$388Average$564FlexibilityNo cancel feeOn-time62%

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