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$238+ Cheap flights from Santo Domingo (SDQ) to San Francisco (SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/16. Fares are subject to change and may not be available on all flights or dates of travel.
SDQ — SFO
Feb 25 — Mar 41
Wed 2/25
Wed 3/4
1 adult, Economy
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Cheap flight deals from Santo Domingo to San Francisco

Cheapest flights from Santo Domingo to San Francisco
Explore the most affordable flight options available from Santo Domingo to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 26, 2026.

This Trip.com deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/105:19 am
SDQ
-
SFO
1 stop17h 15m
JetBlue
Mon 3/168:20 am
SFO
-
SDQ
1 stop16h 11m
JetBlue
Deal found 1/25$461
This Copa Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/302:12 pm
SDQ
-
SFO
1 stop12h 28m
Copa Airlines
Mon 5/41:12 am
SFO
-
SDQ
1 stop12h 03m
Copa Airlines
Deal found 1/25$463
This Trip.com deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/105:19 am
SDQ
-
SFO
1 stop14h 34m
JetBlue
Sun 3/158:20 am
SFO
-
SDQ
1 stop16h 11m
JetBlue
Deal found 1/25$464
This SmartFares deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/119:36 pm
SDQ
-
SFO
1 stop16h 09m
JetBlue
Wed 3/188:25 am
SFO
-
SDQ
1 stop13h 05m
JetBlue
Deal found 1/25$482
This Copa Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/1211:56 am
SDQ
-
SFO
1 stop14h 44m
Copa Airlines
Wed 3/258:42 pm
SFO
-
SDQ
1 stop11h 06m
Copa Airlines
Deal found 1/25$509
This Frontier deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/112:35 pm
SDQ
-
SFO
2 stops15h 53m
Frontier
Tue 3/3110:38 pm
SFO
-
SDQ
1 stop13h 15m
Frontier
Deal found 1/26$511
This Expedia deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/109:36 pm
SDQ
-
SFO
1 stop18h 21m
Multiple Airlines
Mon 3/162:20 pm
SFO
-
SDQ
2 stops18h 05m
Multiple Airlines
Deal found 1/25$516
This Kiwi.com deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/102:32 pm
SDQ
-
SFO
2 stops23h 13m
Multiple Airlines
Sun 3/156:00 am
SFO
-
SDQ
1 stop20h 25m
Multiple Airlines
Deal found 1/25$519
This JetBlue deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/13:20 am
SDQ
-
SFO
1 stop17h 15m
JetBlue
Tue 5/512:20 pm
SFO
-
SDQ
1 stop11h 07m
JetBlue
Deal found 1/24$523

Find flight deals from Santo Domingo to San Francisco

Discover tips and strategies to find the most affordable flight options for your journey from Santo Domingo (SDQ) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 26, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
1 star

Round-trip from

$461
(Trip.com)

One-way from

$238
(Kiwi.com)

Popular in

February

Cheapest in

March

Average price

$557
Provider with most accurate pricing for Santo Domingo Las Americas-San Francisco flight deals.
Search Deals
Provider most trusted by Cheapflights users for Santo Domingo Las Americas-San Francisco flights.
Search Deals
From Santo Domingo Las Americas to San Francisco
Search Deals
One-way flight from Santo Domingo Las Americas to San Francisco
Search Deals
High demand for flights, 2% potential price rise
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($14 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Santo Domingo to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 26, 2026.
Use the filters below to find and compare flights from Santo Domingo to San Francisco that are best for you.

Fly from

Santo Domingo

Fly to

San Francisco

Route

Depart

Return

Price

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Thu 4/30

2:12 pm-11:40 pm

1 stop12h 28m

San Francisco

Mon 5/4

1:12 am-4:15 pm

1 stop12h 03m

$463

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Tue 3/10

5:19 am-4:53 pm

1 stop14h 34m

San Francisco

Sun 3/15

8:20 am-3:31 am

1 stop16h 11m

$464

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Thu 3/12

11:56 am-11:40 pm

1 stop14h 44m

San Francisco

Wed 3/25

8:42 pm-10:48 am

1 stop11h 06m

$509

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Sun 3/1

12:35 pm-12:28 am

2 stops15h 53m

San Francisco

Tue 3/31

10:38 pm-2:53 pm

1 stop13h 15m

$511

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Wed 3/11

10:20 am-11:57 pm

1 stop16h 37m

San Francisco

Wed 3/18

8:25 am-12:30 am

1 stop13h 05m

$515

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Fri 5/1

3:20 am-5:35 pm

1 stop17h 15m

San Francisco

Tue 5/5

12:20 pm-2:27 am

1 stop11h 07m

$523

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Mon 3/16

2:59 am-6:37 pm

3 stops18h 38m

$238

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Tue 3/17

6:28 am-7:31 pm

1 stop16h 03m

$248

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Tue 3/10

9:36 pm-11:28 am

1 stop16h 52m

$250

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Sat 4/11

2:59 am-12:23 am

3 stops48h 24m

$275

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/26

Showing 1-10 of 12 results
1
2
  • Most accurate provider: When it comes to deals on Santo Domingo-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santo Domingo-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santo Domingo-San Francisco flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Santo Domingo-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santo Domingo-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santo Domingo to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Santo Domingo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to San Francisco

What is the cheapest month to book a flight from Santo Domingo to San Francisco?

Currently, March is the cheapest month in which you can book a flight from Santo Domingo to San Francisco (average of $225). Flying from Santo Domingo to San Francisco in August is currently the most expensive (average of $714). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing San Francisco

Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated January 26, 2026.
Peruse reviews from past customers who have flown with JetBlue from Santo Domingo to San Francisco to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
JetBlue
7.2
Good
2,892 reviews

Boarding

7.4

Overall

7.2

Entertainment

7.2

Food

6.6

Comfort

7.5

Crew

8.0

Reviews

1 / 20
4.0
Okay

Jeff,Dec 2025

LAX - BOS

We boarded an hour and a half late and the crew was very salty when asked why. Still got no reason other than someone took the intended plane? Won't fly with them again.
JetBlue
7.2
Good
2,892 reviews
JetBlue
7.2
Good
2,892 reviews

Boarding

7.4

Overall

7.2

Entertainment

7.2

Food

6.6

Comfort

7.5

Crew

8.0

Reviews

1 / 20
4.0
Okay

Jeff,Dec 2025

LAX - BOS

We boarded an hour and a half late and the crew was very salty when asked why. Still got no reason other than someone took the intended plane? Won't fly with them again.

Related info for your journey

Find useful and relevant information for your journey from Santo Domingo to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Santo Domingo to San Francisco?

    A quick flight from Santo Domingo to San Francisco can take about 12h 28m. Copa Airlines provides one of the quickest options available for as low as $463. Santo Domingo and San Francisco are separated by a distance of 3424 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What is the cheapest airline to fly from Santo Domingo to San Francisco round-trip?

    Our cheapest airline available from Santo Domingo to San Francisco is JetBlue. Our recent data shows that you can find tickets from as low as $388 on this airline. JetBlue is currently priced 38% below the average price you’ll pay for this route.

  • What are the cheapest airlines to fly from Santo Domingo to San Francisco one-way?

    For one-way options, check prices for JetBlue. According to our data, you can fly for as low as $246. Users have also found prices from $274 and $311 on Copa Airlines and Delta, respectively.

  • Can I find deals for flights from Santo Domingo to San Francisco that include hotel bookings?

    Yes. In addition to deals on Santo Domingo to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santo Domingo to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to San Francisco.

  • Can I find deals for business class flights from Santo Domingo to San Francisco?

    Yes. Cheapflights offers flight deals from Santo Domingo to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santo Domingo to San Francisco?

    Currently, March is the cheapest month in which you can book a flight from Santo Domingo to San Francisco (average of $225). Flying from Santo Domingo to San Francisco in August is currently the most expensive (average of $714). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
South San Francisco
Santa Cruz
Roseville
Santa Clara
Livermore
Watsonville
San Bruno
Daly City
Sunnyvale
Turlock
Vacaville
San Carlos
San Ramon
Manteca
Vallejo
San Lorenzo
Davis
Hollister
Redwood City
Union City

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Santo Domingo to San Francisco

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Santo Domingo to San Francisco

Discover the top airline that operate flights from Santo Domingo to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 26, 2026.
AirlineCheapestAverageFlexibilityOn-time
JetBlueCheapest$388Average$581FlexibilityNo cancel feeOn-time62%

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