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$228+ Cheap flights from Santo Domingo (SDQ) to San Francisco (SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/16. Fares are subject to change and may not be available on all flights or dates of travel.
SDQ — SFO
oct. 11 — oct. 181
sáb. 10/11
sáb. 10/18
1 adult, Economy
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Cheap flight deals from Santo Domingo to San Francisco

Discover tips and strategies to find the most affordable flight options for your journey from Santo Domingo (SDQ) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated septiembre 11, 2025.

Round-trip from

$428
(SmartFares)

One-way from

$228
(Kiwi.com)

Popular in

February

Cheapest in

September

Average price

$537
From Santo Domingo Las Americas to San Francisco
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One-way flight from Santo Domingo Las Americas to San Francisco
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Highest demand for flights based on searches. 4% potential increase in price ($33 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($12 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Santo Domingo to San Francisco

Cheapest flights from Santo Domingo to San Francisco
Explore the most affordable flight options available from Santo Domingo to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on septiembre 11, 2025.

This SmartFares deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 10/202:34 pmSDQ - SFO
1 stop22h 50mJetBlue
sáb. 10/2511:20 pmSFO - SDQ
1 stop10h 57mJetBlue
Deal found 9/9$428
This Expedia deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/248:10 amSDQ - SFO
1 stop15h 51mJetBlue
mié. 10/298:00 amSFO - SDQ
1 stop26h 17mJetBlue
Deal found 9/10$472
This JetBlue deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 10/2112:47 pmSDQ - SFO
1 stop15h 12mJetBlue
sáb. 10/2511:20 pmSFO - SDQ
1 stop10h 57mJetBlue
Deal found 9/10$473
This JetBlue deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 10/212:54 pmSDQ - SFO
1 stop11h 22mJetBlue
dom. 10/269:44 pmSFO - SDQ
1 stop12h 33mJetBlue
Deal found 9/10$478
This JetBlue deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/63:45 pmSDQ - SFO
1 stop11h 46mJetBlue
dom. 11/99:10 pmSFO - SDQ
1 stop15h 48mJetBlue
Deal found 9/11$480
This JetBlue deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 10/252:34 pmSDQ - SFO
1 stop11h 42mJetBlue
sáb. 11/19:43 pmSFO - SDQ
1 stop13h 48mJetBlue
Deal found 9/10$485
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 10/212:10 pmSDQ - SFO
1 stop12h 29mMultiple Airlines
dom. 10/266:34 amSFO - SDQ
2 stops30h 55mMultiple Airlines
Deal found 9/10$491
This Expedia deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/242:34 pmSDQ - SFO
1 stop11h 31mJetBlue
vie. 10/318:00 amSFO - SDQ
1 stop22h 32mJetBlue
Deal found 9/11$498
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 10/2010:19 amSDQ - SFO
2 stops38h 03mMultiple Airlines
sáb. 10/2510:23 pmSFO - SDQ
1 stop12h 38mMultiple Airlines
Deal found 9/9$504
This JetBlue deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 10/112:34 pmSDQ - SFO
1 stop11h 42mJetBlue
sáb. 10/186:00 amSFO - SDQ
1 stop13h 04mJetBlue
Deal found 9/11$507
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/245:12 pmSDQ - SFO
2 stops31h 11mMultiple Airlines
mar. 10/281:36 amSFO - SDQ
1 stop11h 39mMultiple Airlines
Deal found 9/10$511

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santo Domingo to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 11, 2025.
Use the filters below to find and compare flights from Santo Domingo to San Francisco that are best for you.

Fly from

Santo Domingo

Fly to

San Francisco

Route

Depart

Return

Price

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

lun. 10/20

2:34 pm-10:24 am

1 stop22h 50m

San Francisco

sáb. 10/25

11:20 pm-1:17 pm

1 stop10h 57m

$428

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

mar. 10/21

2:54 pm-11:16 pm

1 stop11h 22m

San Francisco

dom. 10/26

9:44 pm-1:17 pm

1 stop12h 33m

$478

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

jue. 11/6

3:45 pm-11:31 pm

1 stop11h 46m

San Francisco

dom. 11/9

9:10 pm-4:58 pm

1 stop15h 48m

$480

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

sáb. 10/25

2:34 pm-11:16 pm

1 stop11h 42m

San Francisco

sáb. 11/1

9:43 pm-2:31 pm

1 stop13h 48m

$485

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

sáb. 10/11

2:34 pm-11:16 pm

1 stop11h 42m

San Francisco

sáb. 10/18

6:00 am-10:04 pm

1 stop13h 04m

$507

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

sáb. 10/25

11:45 am-10:45 pm

2 stops14h 00m

San Francisco

vie. 10/31

1:36 am-2:26 am

1 stop21h 50m

$535

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

jue. 11/6

2:15 pm-11:17 pm

1 stop13h 02m

San Francisco

dom. 11/9

6:33 pm-5:50 pm

2 stops19h 17m

$536

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

jue. 2/19

2:35 am-10:49 am

1 stop12h 14m

San Francisco

lun. 2/23

10:40 pm-3:17 pm

1 stop12h 37m

$593

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

sáb. 10/25

11:57 am-11:39 pm

1 stop14h 42m

San Francisco

vie. 10/31

1:36 am-2:26 am

1 stop21h 50m

$596

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

sáb. 10/25

11:45 am-11:55 pm

2 stops15h 10m

San Francisco

sáb. 11/1

2:20 pm-4:50 pm

2 stops23h 30m

$605

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Showing 1-10 of 20 results
1
2

Best time to book a flight from Santo Domingo to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Santo Domingo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to San Francisco

What is the cheapest month to book a flight from Santo Domingo to San Francisco?

Currently, January is the cheapest month in which you can book a flight from Santo Domingo to San Francisco (average of $276). Flying from Santo Domingo to San Francisco in June is currently the most expensive (average of $357). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SDQ to SFO?

Find hourly flight availability from Santo Domingo to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated septiembre 11, 2025.

It’s typically best to fly out from Santo Domingo to San Francisco in the evening. Doing so could potentially save you 67% on the flight price compared to flying at noon, which is usually more expensive.

Reviews of airlines servicing San Francisco

Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated septiembre 11, 2025.
Peruse reviews from past customers who have flown with American Airlines and JetBlue from Santo Domingo to San Francisco to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
10,000 reviews

Crew

8.0

Boarding

7.5

Entertainment

6.9

Overall

7.2

Food

6.4

Comfort

7.2

Reviews

1 / 20
10.0
Excellent

Anonymous,Jan 2024

LHR - SAN

This was the best flight I have experienced in all the years I have been f doing this journey with BA. Flight, food and service A1. Well done BA.
American Airlines
7.2
Good
10,000 reviews
American Airlines
7.2
Good
10,000 reviews

Crew

8.0

Boarding

7.5

Entertainment

6.9

Overall

7.2

Food

6.4

Comfort

7.2

Reviews

1 / 20
10.0
Excellent

Anonymous,Jan 2024

LHR - SAN

This was the best flight I have experienced in all the years I have been f doing this journey with BA. Flight, food and service A1. Well done BA.
JetBlue
7.2
Good
2,913 reviews
American Airlines
7.2
Good
10,000 reviews

Crew

8.0

Boarding

7.5

Entertainment

6.9

Overall

7.2

Food

6.4

Comfort

7.2

Reviews

1 / 20
10.0
Excellent

Anonymous,Jan 2024

LHR - SAN

This was the best flight I have experienced in all the years I have been f doing this journey with BA. Flight, food and service A1. Well done BA.

Related info for your journey

Find useful and relevant information for your journey from Santo Domingo to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Santo Domingo to San Francisco?

    A quick flight from Santo Domingo to San Francisco can take about 22h 50m. JetBlue provides one of the quickest options available for as low as $428. Santo Domingo and San Francisco are separated by a distance of 3424 mi.

  • What are the cheapest airlines flying from Santo Domingo to San Francisco round-trip?

    Our cheapest airline available from Santo Domingo to San Francisco is JetBlue. Our recent data shows that you can find tickets from as low as $480 on this airline. An additional option worth looking into is American Airlines, starting at $689. JetBlue is currently priced 27% below the average price you’ll pay for this route.

  • Can I find deals for flights from Santo Domingo to San Francisco that include hotel bookings?

    Yes. In addition to deals on Santo Domingo to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santo Domingo to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to San Francisco.

  • Can I find deals for business class flights from Santo Domingo to San Francisco?

    Yes. Cheapflights offers flight deals from Santo Domingo to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santo Domingo to San Francisco?

    Currently, January is the cheapest month in which you can book a flight from Santo Domingo to San Francisco (average of $276). Flying from Santo Domingo to San Francisco in June is currently the most expensive (average of $357). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Roseville
Santa Cruz
Livermore
South San Francisco
Turlock
Antioch
Watsonville
Manteca
Santa Clara
Sunnyvale
Hollister
Vacaville
Foster City
Vallejo
Burlingame
Redwood City
Union City
San Leandro
San Mateo
Lathrop

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Santo Domingo to San Francisco

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Top 2 airlines flying from Santo Domingo to San Francisco

Discover the top 2 airlines that operate flights from Santo Domingo to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
JetBlueCheapest$480Average$630FlexibilityNo cancel feeOn-time62%
American AirlinesCheapest$689Average$790FlexibilityNo cancel feeOn-time71%

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