How long is the flight from Santo Domingo to San Francisco?

A quick flight from Santo Domingo to San Francisco can take about 15h 53m. Avianca provides one of the quickest options available for as low as $501. Santo Domingo and San Francisco are separated by a distance of 3424 mi. Both multi-stop and nonstop flights can be found to your destination and back.

What are the cheapest airlines flying from Santo Domingo to San Francisco round-trip?

Our cheapest airline available from Santo Domingo to San Francisco is JetBlue. Our recent data shows that you can find tickets from as low as $458 on this airline. An additional option worth looking into is American Airlines, starting at $689. JetBlue is currently priced 31% below the average price you’ll pay for this route.

What are the cheapest airlines to fly from Santo Domingo to San Francisco one-way?

For one-way options, check prices for JetBlue. According to our data, you can fly for as low as $177. Users have also found prices from $274 and $348 on Copa Airlines and Aeromexico, respectively.

In terms of precipitation, rainfall in San Francisco ranges from 0.0 - 4.4 inches per month. January is typically the wettest month, when rainfall can reach 4.4 in. July is typically the driest time to visit San Francisco when rainfall is around 0.0 in.

If weather is an important factor for your trip to San Francisco, use this chart to help with planning. For those seeking warmer temperatures, September is the ideal time of year to visit, when temperatures reach an average of 62.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 51.8 F).

Most accurate provider : When it comes to deals on Santo Domingo-San Francisco flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Santo Domingo-San Francisco flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Santo Domingo-San Francisco flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Santo Domingo-San Francisco flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santo Domingo-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Santo Domingo to San Francisco that include hotel bookings?

Yes. In addition to deals on Santo Domingo to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Santo Domingo to San Francisco?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to San Francisco.

Can I find deals for business class flights from Santo Domingo to San Francisco?

Yes. Cheapflights offers flight deals from Santo Domingo to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$190+ Flights from Santo Domingo to San Francisco

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Cheap flight deals from Santo Domingo to San Francisco

Cheapest flights from Santo Domingo to San Francisco
Explore the most affordable flight options available from Santo Domingo to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

Thu 12/254:39 pmSDQ - SFO

1 stop24h 34mFrontier

Mon 12/296:24 amSFO - SDQ

2 stops28h 55mFrontier

Deal found 12/9

$725

Sun 12/286:57 pmSDQ - SFO

1 stop20h 12mAmerican Airlines

Wed 1/710:59 pmSFO - SDQ

1 stop12h 44mAmerican Airlines

Deal found 12/11

$935

Sun 12/286:57 pmSDQ - SFO

1 stop20h 12mAmerican Airlines

Mon 1/59:47 pmSFO - SDQ

1 stop13h 56mAmerican Airlines

Deal found 12/10

$953

Thu 12/254:51 pmSDQ - SFO

2 stops21h 01mAmerican Airlines

Mon 12/293:51 pmSFO - SDQ

2 stops14h 16mAmerican Airlines

Deal found 12/9

$963

Best flights from Santo Domingo to San Francisco
Discover carefully curated flight deals from Santo Domingo to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 12, 2025.

Thu 1/154:42 pmSDQ - SFO

1 stop24h 42mMultiple Airlines

Wed 1/282:08 pmSFO - SDQ

2 stops20h 19mMultiple Airlines

Deal found 12/11

$436

Thu 1/2212:20 pmSDQ - SFO

2 stops27h 40mAvianca

Thu 1/291:20 pmSFO - SDQ

2 stops23h 30mAvianca

Deal found 12/11

$492

Thu 1/156:01 amSDQ - SFO

1 stop15h 53mJetBlue

Wed 1/288:00 amSFO - SDQ

1 stop26h 14mJetBlue

Deal found 12/11

$501

Thu 1/2212:20 pmSDQ - SFO

2 stops27h 40mMultiple Airlines

Thu 1/2910:50 amSFO - SDQ

1 stop12h 03mMultiple Airlines

Deal found 12/11

$495

Sat 1/243:30 pmSDQ - SFO

1 stop11h 58mJetBlue

Sat 1/3110:37 pmSFO - SDQ

1 stop11h 17mJetBlue

Deal found 12/10

$527

Sat 1/243:32 pmSDQ - SFO

1 stop11h 56mMultiple Airlines

Sat 1/318:00 amSFO - SDQ

1 stop26h 27mMultiple Airlines

Deal found 12/10

$524

Sun 1/255:10 pmSDQ - SFO

2 stops35h 18mMultiple Airlines

Sun 2/16:15 amSFO - SDQ

3 stops34h 04mMultiple Airlines

Deal found 12/11

$543

Sun 1/253:30 pmSDQ - SFO

1 stop11h 59mJetBlue

Sun 2/112:40 pmSFO - SDQ

1 stop10h 13mJetBlue

Deal found 12/10

$601

Last-minute flights from Santo Domingo to San Francisco
Discover last-minute flight deals from Santo Domingo to San Francisco. Data last updated December 12, 2025 and is based on user searches.

Thu 1/154:42 pmSDQ - SFO

1 stop24h 42mMultiple Airlines

Wed 1/282:08 pmSFO - SDQ

2 stops20h 19mMultiple Airlines

Deal found 12/11

$436

Thu 1/156:01 amSDQ - SFO

1 stop15h 53mJetBlue

Wed 1/288:00 amSFO - SDQ

1 stop26h 14mJetBlue

Deal found 12/11

$501

Thu 1/2212:20 pmSDQ - SFO

2 stops27h 40mAvianca

Thu 1/291:20 pmSFO - SDQ

2 stops23h 30mAvianca

Deal found 12/11

$492

Thu 1/2212:20 pmSDQ - SFO

2 stops27h 40mMultiple Airlines

Thu 1/2910:50 amSFO - SDQ

1 stop12h 03mMultiple Airlines

Deal found 12/11

$495

Sat 1/243:32 pmSDQ - SFO

1 stop11h 56mMultiple Airlines

Sat 1/318:00 amSFO - SDQ

1 stop26h 27mMultiple Airlines

Deal found 12/10

$524

Sat 1/243:30 pmSDQ - SFO

1 stop11h 58mJetBlue

Sat 1/3110:37 pmSFO - SDQ

1 stop11h 17mJetBlue

Deal found 12/10

$527

Sun 1/253:30 pmSDQ - SFO

1 stop11h 59mJetBlue

Sun 2/111:59 pmSFO - SDQ

1 stop10h 15mJetBlue

Deal found 12/11

$480

Sun 1/255:10 pmSDQ - SFO

2 stops35h 18mMultiple Airlines

Sun 2/16:15 amSFO - SDQ

3 stops34h 04mMultiple Airlines

Deal found 12/11

$543

One-way flights from Santo Domingo to San Francisco
Search for one-way flight options from Santo Domingo to San Francisco. Find affordable one-way fares based on user searches. Data last updated December 12, 2025.

Thu 2/2612:31 pmSDQ - SFO

2 stops33h 27mFrontier

Deal found 12/10

$190

Mon 2/2310:19 amSDQ - SFO

2 stops39h 42mMultiple Airlines

Deal found 12/10

$212

Tue 2/173:35 pmSDQ - SFO

2 stops44h 28mMultiple Airlines

Deal found 12/10

$223

Fri 2/2010:19 amSDQ - SFO

3 stops51h 37mMultiple Airlines

Deal found 12/10

$232

Wed 2/1810:19 amSDQ - SFO

2 stops49h 44mMultiple Airlines

Deal found 12/10

$234

Sun 2/223:32 pmSDQ - SFO

3 stops36h 56mMultiple Airlines

Deal found 12/10

$235

Thu 2/193:32 pmSDQ - SFO

3 stops44h 31mMultiple Airlines

Deal found 12/10

$241

Tue 2/243:28 pmSDQ - SFO

1 stop12h 30mJetBlue

Deal found 12/10

$243

Sun 2/2210:46 amSDQ - SFO

2 stops32h 22mFrontier

Deal found 12/10

$246

Tue 3/105:19 amSDQ - SFO

1 stop14h 23mJetBlue

Deal found 12/10

$249

Find flight deals from Santo Domingo to San Francisco

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$436 (Kiwi.com)
One-way from	$190 (Kiwi.com)
Popular in	January
Cheapest in	September
Average price	$747

Provider with most accurate pricing for Santo Domingo Las Americas-San Francisco flight deals.

Search Deals

Provider most trusted by Cheapflights users for Santo Domingo Las Americas-San Francisco flights.

Search Deals

From Santo Domingo Las Americas to San Francisco

Search Deals

One-way flight from Santo Domingo Las Americas to San Francisco

Search Deals

Highest demand for flights based on searches. 16% potential increase in price ($126 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 2% potential price decrease ($17 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in December 2025

Search Deals

Cheapflights Fare Finder

Use the filters below to find and compare flights from Santo Domingo to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Thu 1/15

4:42 pm-1:24 pm

1 stop24h 42m

San Francisco

Wed 1/28

2:08 pm-2:27 pm

2 stops20h 19m

$436

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Thu 1/22

12:20 pm-12:00 pm

2 stops27h 40m

San Francisco

Thu 1/29

1:20 pm-4:50 pm

2 stops23h 30m

$492

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Thu 1/22

12:20 pm-12:00 pm

2 stops27h 40m

San Francisco

Thu 1/29

10:50 am-2:53 am

1 stop12h 03m

$495

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Thu 1/15

6:01 am-5:54 pm

1 stop15h 53m

San Francisco

Wed 1/28

8:00 am-2:14 pm

1 stop26h 14m

$501

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Sat 1/24

3:32 pm-11:28 pm

1 stop11h 56m

San Francisco

Sat 1/31

8:00 am-2:27 pm

1 stop26h 27m

$524

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Sat 1/24

3:30 pm-11:28 pm

1 stop11h 58m

San Francisco

Sat 1/31

10:37 pm-1:54 pm

1 stop11h 17m

$527

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Sun 1/25

5:10 pm-12:28 am

2 stops35h 18m

San Francisco

Sun 2/1

6:15 am-8:19 pm

3 stops34h 04m

$543

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Sun 1/25

3:30 pm-11:29 pm

1 stop11h 59m

San Francisco

Sun 2/1

12:40 pm-2:53 am

1 stop10h 13m

$601

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Thu 2/26

12:31 pm-5:58 pm

2 stops33h 27m

$190

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Tue 2/24

3:35 pm-12:28 am

2 stops36h 53m

$212

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/10

Showing 1-10 of 17 results

Compare providers for flights from Santo Domingo to San Francisco

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santo Domingo to San Francisco in December.

Provider	Price Accuracy	Trust Score*
FlightHub	Price Accuracy3 stars	Trust Score*1 star
eDreams	Price Accuracy3 stars	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Santo Domingo-San Francisco flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Santo Domingo-San Francisco flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Santo Domingo-San Francisco flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Santo Domingo-San Francisco flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santo Domingo-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santo Domingo to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Santo Domingo with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to San Francisco

What is the cheapest month to book a flight from Santo Domingo to San Francisco?

Currently, September is the cheapest month in which you can book a flight from Santo Domingo to San Francisco (average of $261). Flying from Santo Domingo to San Francisco in August is currently the most expensive (average of $714). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SDQ to SFO?

It’s typically best to fly out from Santo Domingo to San Francisco in the evening. Doing so could potentially save you 66% on the flight price compared to flying at noon, which is usually more expensive.

Reviews of airlines servicing San Francisco

Peruse reviews from past customers who have flown with American Airlines and JetBlue from Santo Domingo to San Francisco to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

American Airlines

7.2

Good

11,048 reviews

Reviews

1 / 20

10.0

Excellent

Anonymous,Jan 2024

LHR - SAN

This was the best flight I have experienced in all the years I have been f doing this journey with BA. Flight, food and service A1. Well done BA.

American Airlines

7.2

Good

11,048 reviews

American Airlines

7.2

Good

11,048 reviews

Reviews

1 / 20

10.0

Excellent

Anonymous,Jan 2024

LHR - SAN

This was the best flight I have experienced in all the years I have been f doing this journey with BA. Flight, food and service A1. Well done BA.

JetBlue

7.2

Good

2,898 reviews

American Airlines

7.2

Good

11,048 reviews

Reviews

1 / 20

10.0

Excellent

Anonymous,Jan 2024

LHR - SAN

This was the best flight I have experienced in all the years I have been f doing this journey with BA. Flight, food and service A1. Well done BA.

Related info for your journey

How long is the flight from Santo Domingo to San Francisco?
A quick flight from Santo Domingo to San Francisco can take about 15h 53m. Avianca provides one of the quickest options available for as low as $501. Santo Domingo and San Francisco are separated by a distance of 3424 mi. Both multi-stop and nonstop flights can be found to your destination and back.
What are the cheapest airlines flying from Santo Domingo to San Francisco round-trip?
Our cheapest airline available from Santo Domingo to San Francisco is JetBlue. Our recent data shows that you can find tickets from as low as $458 on this airline. An additional option worth looking into is American Airlines, starting at $689. JetBlue is currently priced 31% below the average price you’ll pay for this route.
What are the cheapest airlines to fly from Santo Domingo to San Francisco one-way?
For one-way options, check prices for JetBlue. According to our data, you can fly for as low as $177. Users have also found prices from $274 and $348 on Copa Airlines and Aeromexico, respectively.
Can I find deals for flights from Santo Domingo to San Francisco that include hotel bookings?
Yes. In addition to deals on Santo Domingo to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Santo Domingo to San Francisco?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to San Francisco.
Can I find deals for business class flights from Santo Domingo to San Francisco?
Yes. Cheapflights offers flight deals from Santo Domingo to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Santo Domingo to San Francisco?
Currently, September is the cheapest month in which you can book a flight from Santo Domingo to San Francisco (average of $261). Flying from Santo Domingo to San Francisco in August is currently the most expensive (average of $714). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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South San Francisco

Santa Cruz

Livermore

Turlock

Manteca

Watsonville

Sunnyvale

Santa Clara

San Bruno

Redwood City

Daly City

Vallejo

Hollister

Foster City

Union City

Davis

San Ramon

Burlingame

Milpitas

Browse thousands of different options on Cheapflights for your next trip

Alternative routes for Santo Domingo to San Francisco

Top 2 airlines flying from Santo Domingo to San Francisco

Airline	Cheapest	Average	Flexibility	On-time
JetBlue	Cheapest$486	Average$600	FlexibilityNo cancel fee	On-time62%
American Airlines	Cheapest$689	Average$790	FlexibilityNo cancel fee	On-time71%

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$190+ Cheap flights from Santo Domingo (SDQ) to San Francisco (SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/26. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Santo Domingo to San Francisco with Cheapflights

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Cheap flight deals from Santo Domingo to San Francisco

Cheapest flights from Santo Domingo to San FranciscoExplore the most affordable flight options available from Santo Domingo to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

Explore the most affordable flight options available from Santo Domingo to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

Find flight deals from Santo Domingo to San Francisco

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Cheapflights Fare Finder

Use the filters below to find and compare flights from Santo Domingo to San Francisco that are best for you.

Compare providers for flights from Santo Domingo to San Francisco

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santo Domingo to San Francisco in December.

Best time to book a flight from Santo Domingo to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Santo Domingo with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to San Francisco

What is the cheapest month to book a flight from Santo Domingo to San Francisco?

What is the cheapest time of day to fly from SDQ to SFO?

Reviews of airlines servicing San Francisco

Peruse reviews from past customers who have flown with American Airlines and JetBlue from Santo Domingo to San Francisco to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Santo Domingo to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from Santo Domingo to San Francisco?

What are the cheapest airlines flying from Santo Domingo to San Francisco round-trip?

What are the cheapest airlines to fly from Santo Domingo to San Francisco one-way?

Can I find deals for flights from Santo Domingo to San Francisco that include hotel bookings?

How can I find direct flights from Santo Domingo to San Francisco?

Can I find deals for business class flights from Santo Domingo to San Francisco?

What is the cheapest month to book a flight from Santo Domingo to San Francisco?

Traveling to a place near San Francisco?

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Alternative routes for Santo Domingo to San Francisco

See prices for flight routes from nearby airports that may be better suited for you.

Top 2 airlines flying from Santo Domingo to San Francisco

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Cheapest flights from Santo Domingo to San Francisco
Explore the most affordable flight options available from Santo Domingo to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.