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$483+ Cheap flights from Santa Cruz de la Sierra (VVI) to San Francisco (SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/5. Fares are subject to change and may not be available on all flights or dates of travel.
VVI — SFO
Feb 26 — Mar 51
Thu 2/26
Thu 3/5
1 adult, Economy
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Cheap flight deals from Santa Cruz de la Sierra to San Francisco

Cheapest flights from Santa Cruz de la Sierra to San Francisco
Explore the most affordable flight options available from Santa Cruz de la Sierra to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 27, 2026.

This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/711:42 am
VVI
-
SFO
2 stops24h 40m
United Airlines
Wed 3/185:15 pm
SFO
-
VVI
2 stops26h 35m
United Airlines
Deal found 1/27$855
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/211:42 am
VVI
-
SFO
2 stops23h 49m
United Airlines
Mon 3/1610:45 pm
SFO
-
VVI
2 stops21h 05m
United Airlines
Deal found 1/27$872
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/211:42 am
VVI
-
SFO
2 stops33h 26m
United Airlines
Sun 3/1511:59 pm
SFO
-
VVI
2 stops19h 51m
United Airlines
Deal found 1/27$889
This Priceline deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/233:40 am
VVI
-
SFO
2 stops23h 00m
Avianca
Tue 4/711:55 pm
SFO
-
VVI
2 stops22h 55m
Avianca
Deal found 1/26$919
This Gotogate deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/233:40 am
VVI
-
SFO
2 stops23h 00m
Avianca
Mon 4/611:55 pm
SFO
-
VVI
2 stops22h 55m
Avianca
Deal found 1/26$992
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/311:42 am
VVI
-
SFO
2 stops26h 11m
United Airlines
Tue 3/1711:20 pm
SFO
-
VVI
2 stops20h 30m
United Airlines
Deal found 1/27$1,058
This Mytrip deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/245:20 am
VVI
-
SFO
3 stops34h 40m
Multiple Airlines
Tue 3/311:10 pm
SFO
-
VVI
2 stops23h 25m
Multiple Airlines
Deal found 1/26$1,059
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/311:42 am
VVI
-
SFO
2 stops37h 03m
United Airlines
Sun 3/1511:59 pm
SFO
-
VVI
2 stops19h 51m
United Airlines
Deal found 1/27$1,075
This Mytrip deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/2412:15 pm
VVI
-
SFO
3 stops27h 45m
Multiple Airlines
Tue 4/711:55 pm
SFO
-
VVI
2 stops22h 55m
Multiple Airlines
Deal found 1/26$1,122
This Orbitz deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/233:40 am
VVI
-
SFO
2 stops36h 20m
Avianca
Tue 3/31:20 pm
SFO
-
VVI
2 stops33h 15m
Avianca
Deal found 1/26$1,136
This Mytrip deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/2412:15 pm
VVI
-
SFO
3 stops27h 45m
Multiple Airlines
Mon 4/611:55 pm
SFO
-
VVI
2 stops22h 55m
Multiple Airlines
Deal found 1/26$1,190
This FlightHub deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/33:40 am
VVI
-
SFO
2 stops22h 10m
Avianca
Sat 3/142:35 am
SFO
-
VVI
2 stops21h 00m
Avianca
Deal found 1/27$1,192

Find flight deals from Santa Cruz de la Sierra to San Francisco

Discover tips and strategies to find the most affordable flight options for your journey from Santa Cruz de la Sierra (VVI) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 27, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$855
(United Airlines)

One-way from

$483
(United Airlines)

Popular in

March

Cheapest in

September

Average price

$932
Provider with most accurate pricing for Santa Cruz de la Sierra Viru Viru Intl-San Francisco flight deals.
Search Deals
Provider most trusted by Cheapflights users for Santa Cruz de la Sierra Viru Viru Intl-San Francisco flights.
Search Deals
From Santa Cruz de la Sierra Viru Viru Intl to San Francisco
Search Deals
One-way flight from Santa Cruz de la Sierra Viru Viru Intl to San Francisco
Search Deals
Highest demand for flights based on searches. 19% potential increase in price ($211 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($27 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santa Cruz de la Sierra to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 27, 2026.
Use the filters below to find and compare flights from Santa Cruz de la Sierra to San Francisco that are best for you.

Fly from

Santa Cruz de la Sierra

Fly to

San Francisco

Route

Depart

Return

Price

Santa Cruz de la SierraSan Francisco

VVI - SFO

VVISFO

Santa Cruz de la Sierra Viru Viru Intl

Sat 3/7

11:42 am-8:22 am

2 stops24h 40m

San Francisco

Mon 3/16

11:20 pm-10:50 pm

2 stops20h 30m

$855

Santa Cruz de la SierraSan Francisco

VVI - SFO

VVISFO

Santa Cruz de la Sierra Viru Viru Intl

Sat 3/7

11:42 am-8:22 am

2 stops24h 40m

San Francisco

Wed 3/18

5:15 pm-10:50 pm

2 stops26h 35m

$855

Santa Cruz de la SierraSan Francisco

VVI - SFO

VVISFO

Santa Cruz de la Sierra Viru Viru Intl

Thu 3/5

11:42 am-9:30 am

2 stops25h 48m

San Francisco

Wed 3/18

10:45 pm-10:50 pm

2 stops21h 05m

$872

Santa Cruz de la SierraSan Francisco

VVI - SFO

VVISFO

Santa Cruz de la Sierra Viru Viru Intl

Mon 3/2

11:42 am-5:08 pm

2 stops33h 26m

San Francisco

Tue 3/17

9:30 pm-10:50 pm

2 stops22h 20m

$872

Santa Cruz de la SierraSan Francisco

VVI - SFO

VVISFO

Santa Cruz de la Sierra Viru Viru Intl

Thu 3/5

11:42 am-9:30 am

2 stops25h 48m

San Francisco

Mon 3/16

11:59 pm-10:50 pm

2 stops19h 51m

$872

Santa Cruz de la SierraSan Francisco

VVI - SFO

VVISFO

Santa Cruz de la Sierra Viru Viru Intl

Sat 3/7

11:42 am-8:22 am

2 stops24h 40m

San Francisco

Sun 3/15

11:59 pm-10:50 pm

2 stops19h 51m

$872

Santa Cruz de la SierraSan Francisco

VVI - SFO

VVISFO

Santa Cruz de la Sierra Viru Viru Intl

Mon 3/2

11:42 am-7:31 am

2 stops23h 49m

San Francisco

Mon 3/16

10:45 pm-10:50 pm

2 stops21h 05m

$872

Santa Cruz de la SierraSan Francisco

VVI - SFO

VVISFO

Santa Cruz de la Sierra Viru Viru Intl

Mon 3/2

11:42 am-5:08 pm

2 stops33h 26m

San Francisco

Wed 3/18

10:45 pm-10:50 pm

2 stops21h 05m

$872

Santa Cruz de la SierraSan Francisco

VVI - SFO

VVISFO

Santa Cruz de la Sierra Viru Viru Intl

Sat 3/7

11:42 am-8:22 am

2 stops24h 40m

San Francisco

Fri 3/13

6:44 pm-10:50 pm

2 stops25h 06m

$872

Santa Cruz de la SierraSan Francisco

VVI - SFO

VVISFO

Santa Cruz de la Sierra Viru Viru Intl

Thu 3/5

11:42 am-9:30 am

2 stops25h 48m

San Francisco

Tue 3/17

11:20 pm-10:50 pm

2 stops20h 30m

$872

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/25

Showing 1-10 of 18 results
1
2
  • Most accurate provider: When it comes to deals on Santa Cruz de la Sierra-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santa Cruz de la Sierra-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santa Cruz de la Sierra-San Francisco flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Santa Cruz de la Sierra-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santa Cruz de la Sierra-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santa Cruz de la Sierra to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Santa Cruz de la Sierra with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santa Cruz de la Sierra to San Francisco

What is the cheapest month to book a flight from Santa Cruz de la Sierra to San Francisco?

Currently, December is the cheapest month in which you can book a flight from Santa Cruz de la Sierra to San Francisco (average of $322). Flying from Santa Cruz de la Sierra to San Francisco in March is currently the most expensive (average of $956). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing San Francisco

Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated January 27, 2026.
Read reviews from past customers who have flown Copa Airlines, United Airlines, and Avianca from Santa Cruz de la Sierra to San Francisco. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,558 reviews

Crew

8.1

Food

6.8

Comfort

7.4

Overall

7.6

Boarding

7.8

Entertainment

6.8

Reviews

1 / 20
2.0
Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it
Copa Airlines
7.6
Good
1,558 reviews
Copa Airlines
7.6
Good
1,558 reviews

Crew

8.1

Food

6.8

Comfort

7.4

Overall

7.6

Boarding

7.8

Entertainment

6.8

Reviews

1 / 20
2.0
Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it
United Airlines
7.4
Good
9,205 reviews
Copa Airlines
7.6
Good
1,558 reviews

Crew

8.1

Food

6.8

Comfort

7.4

Overall

7.6

Boarding

7.8

Entertainment

6.8

Reviews

1 / 20
2.0
Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it
Avianca
6.6
Okay
2,487 reviews
Copa Airlines
7.6
Good
1,558 reviews

Crew

8.1

Food

6.8

Comfort

7.4

Overall

7.6

Boarding

7.8

Entertainment

6.8

Reviews

1 / 20
2.0
Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it

Related info for your journey

Find useful and relevant information for your journey from Santa Cruz de la Sierra to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Santa Cruz de la Sierra to San Francisco?

    United Airlines can get you from Santa Cruz de la Sierra to San Francisco in just under 24h 40m. Your travel time can differ by up to . Airlines will cover a distance of 5414 mi.

  • What are the cheapest airlines flying from Santa Cruz de la Sierra to San Francisco round-trip?

    According to our current data, United Airlines ($299), Copa Airlines ($401), and Avianca ($706) offers the cheapest pricing from Santa Cruz de la Sierra to San Francisco. United Airlines is 64% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Santa Cruz de la Sierra to San Francisco that include hotel bookings?

    Yes. In addition to deals on Santa Cruz de la Sierra to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santa Cruz de la Sierra to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santa Cruz de la Sierra to San Francisco.

  • Can I find deals for business class flights from Santa Cruz de la Sierra to San Francisco?

    Yes. Cheapflights offers flight deals from Santa Cruz de la Sierra to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santa Cruz de la Sierra to San Francisco?

    Currently, December is the cheapest month in which you can book a flight from Santa Cruz de la Sierra to San Francisco (average of $322). Flying from Santa Cruz de la Sierra to San Francisco in March is currently the most expensive (average of $956). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
South San Francisco
Santa Cruz
Roseville
Santa Clara
Livermore
Watsonville
San Bruno
Daly City
Sunnyvale
Turlock
Vacaville
San Carlos
San Ramon
Manteca
Vallejo
San Lorenzo
Davis
Hollister
Redwood City
Union City

Browse thousands of different options on Cheapflights for your next trip

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Top 3 airlines flying from Santa Cruz de la Sierra to San Francisco

Discover the top 3 airlines that operate flights from Santa Cruz de la Sierra to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 27, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$299Average$837FlexibilityNo cancel feeOn-time69%
Copa AirlinesCheapest$401Average$1,102FlexibilityNo cancel feeOn-time70%
AviancaCheapest$706Average$1,067FlexibilityNo cancel feeOn-time71%

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