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$435+ Cheap flights from Santa Cruz de la Sierra (VVI) to San Francisco (SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/4. Fares are subject to change and may not be available on all flights or dates of travel.
VVI — SFO
oct. 11 — oct. 181
sáb. 10/11
sáb. 10/18
1 adult, Economy
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Cheap flight deals from Santa Cruz de la Sierra to San Francisco

Discover tips and strategies to find the most affordable flight options for your journey from Santa Cruz de la Sierra (VVI) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated septiembre 11, 2025.

Round-trip from

$806
(Copa Airlines)

One-way from

$435
(Kiwi.com)

Popular in

March

Cheapest in

August

Average price

$478
From Santa Cruz de la Sierra Viru Viru Intl to San Francisco
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One-way flight from Santa Cruz de la Sierra Viru Viru Intl to San Francisco
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Highest demand for flights based on searches. 17% potential increase in price ($176 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($28 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Santa Cruz de la Sierra to San Francisco

Cheapest flights from Santa Cruz de la Sierra to San Francisco
Explore the most affordable flight options available from Santa Cruz de la Sierra to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on septiembre 11, 2025.

This Copa Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 9/2212:15 pmVVI - SFO
1 stop14h 10mCopa Airlines
sáb. 10/181:31 amSFO - VVI
1 stop18h 09mCopa Airlines
Deal found 9/11$806
This United deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 10/202:50 amVVI - SFO
2 stops17h 56mMultiple Airlines
mié. 11/1911:59 pmSFO - VVI
2 stops18h 47mMultiple Airlines
Deal found 9/11$810
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 9/211:09 amVVI - SFO
2 stops19h 37mUnited Airlines
dom. 10/195:00 amSFO - VVI
2 stops38h 40mUnited Airlines
Deal found 9/11$811
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 11/171:09 amVVI - SFO
2 stops24h 14mUnited Airlines
dom. 11/3012:43 amSFO - VVI
2 stops18h 03mUnited Airlines
Deal found 9/11$828
This United deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/242:50 amVVI - SFO
2 stops17h 56mMultiple Airlines
lun. 12/111:59 pmSFO - VVI
2 stops18h 47mMultiple Airlines
Deal found 9/9$844
This Booking.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 10/202:50 amVVI - SFO
2 stops22h 55mAvianca
mar. 11/181:35 amSFO - VVI
2 stops21h 00mAvianca
Deal found 9/11$1,001
This Copa Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 11/1811:40 amVVI - SFO
1 stop15h 37mCopa Airlines
dom. 11/3012:36 amSFO - VVI
1 stop18h 10mCopa Airlines
Deal found 9/10$1,010
This Cheapflightsfares deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/173:40 amVVI - SFO
2 stops23h 40mAvianca
mié. 1/711:10 pmSFO - VVI
2 stops23h 25mAvianca
Deal found 9/10$1,048
This Cheapflightsfares deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 9/212:50 amVVI - SFO
2 stops22h 55mAvianca
sáb. 10/1812:05 amSFO - VVI
2 stops22h 45mAvianca
Deal found 9/11$1,058

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santa Cruz de la Sierra to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 11, 2025.
Use the filters below to find and compare flights from Santa Cruz de la Sierra to San Francisco that are best for you.

Fly from

Santa Cruz de la Sierra

Fly to

San Francisco

Route

Depart

Return

Price

Santa Cruz de la SierraSan Francisco

VVI - SFO

VVISFO

Santa Cruz de la Sierra Viru Viru Intl

dom. 9/21

1:09 am-11:59 pm

2 stops25h 50m

San Francisco

dom. 10/19

11:59 pm-10:40 pm

2 stops19h 41m

$811

Santa Cruz de la SierraSan Francisco

VVI - SFO

VVISFO

Santa Cruz de la Sierra Viru Viru Intl

vie. 10/24

1:09 am-11:57 pm

3 stops25h 48m

San Francisco

lun. 12/1

11:59 pm-10:46 pm

2 stops18h 47m

$828

Santa Cruz de la SierraSan Francisco

VVI - SFO

VVISFO

Santa Cruz de la Sierra Viru Viru Intl

lun. 11/17

1:09 am-9:36 am

2 stops36h 27m

San Francisco

lun. 12/1

11:59 pm-10:46 pm

2 stops18h 47m

$828

Santa Cruz de la SierraSan Francisco

VVI - SFO

VVISFO

Santa Cruz de la Sierra Viru Viru Intl

lun. 3/2

3:40 am-11:55 pm

2 stops24h 15m

San Francisco

mié. 4/15

2:45 pm-10:13 pm

2 stops28h 28m

$844

Santa Cruz de la SierraSan Francisco

VVI - SFO

VVISFO

Santa Cruz de la Sierra Viru Viru Intl

mar. 3/3

11:42 am-11:16 pm

1 stop15h 34m

San Francisco

mar. 4/14

1:37 am-10:50 pm

1 stop18h 13m

$883

Santa Cruz de la SierraSan Francisco

VVI - SFO

VVISFO

Santa Cruz de la Sierra Viru Viru Intl

mié. 12/17

3:40 am-11:20 pm

2 stops23h 40m

San Francisco

mié. 1/7

11:10 pm-2:35 am

2 stops23h 25m

$1,048

Santa Cruz de la SierraSan Francisco

VVI - SFO

VVISFO

Santa Cruz de la Sierra Viru Viru Intl

mar. 11/18

11:40 am-11:17 pm

1 stop15h 37m

San Francisco

dom. 11/30

12:36 am-3:36 am

1 stop23h 00m

$1,049

Santa Cruz de la SierraSan Francisco

VVI - SFO

VVISFO

Santa Cruz de la Sierra Viru Viru Intl

lun. 10/20

2:50 am-12:19 pm

2 stops36h 29m

San Francisco

mié. 11/19

8:45 am-10:46 pm

1 stop34h 01m

$1,104

Santa Cruz de la SierraSan Francisco

VVI - SFO

VVISFO

Santa Cruz de la Sierra Viru Viru Intl

mar. 11/4

3:40 am-12:15 pm

2 stops36h 35m

$435

Santa Cruz de la SierraSan Francisco

VVI - SFO

VVISFO

Santa Cruz de la Sierra Viru Viru Intl

sáb. 11/1

3:40 am-1:10 pm

2 stops36h 30m

$435

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Showing 1-10 of 19 results
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Best time to book a flight from Santa Cruz de la Sierra to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Santa Cruz de la Sierra with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santa Cruz de la Sierra to San Francisco

What is the cheapest month to book a flight from Santa Cruz de la Sierra to San Francisco?

Currently, January is the cheapest month in which you can book a flight from Santa Cruz de la Sierra to San Francisco (average of $276). Flying from Santa Cruz de la Sierra to San Francisco in June is currently the most expensive (average of $357). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing San Francisco

Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated septiembre 11, 2025.
Read reviews from past customers who have flown Copa Airlines, United Airlines, and Avianca from Santa Cruz de la Sierra to San Francisco. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,531 reviews

Comfort

7.4

Entertainment

6.8

Overall

7.6

Food

6.8

Crew

8.1

Boarding

7.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Copa Airlines
7.6
Good
1,531 reviews
Copa Airlines
7.6
Good
1,531 reviews

Comfort

7.4

Entertainment

6.8

Overall

7.6

Food

6.8

Crew

8.1

Boarding

7.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
United Airlines
7.4
Good
8,937 reviews
Copa Airlines
7.6
Good
1,531 reviews

Comfort

7.4

Entertainment

6.8

Overall

7.6

Food

6.8

Crew

8.1

Boarding

7.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Avianca
6.7
Okay
2,436 reviews
Copa Airlines
7.6
Good
1,531 reviews

Comfort

7.4

Entertainment

6.8

Overall

7.6

Food

6.8

Crew

8.1

Boarding

7.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip

Related info for your journey

Find useful and relevant information for your journey from Santa Cruz de la Sierra to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Santa Cruz de la Sierra to San Francisco?

    United Airlines can get you from Santa Cruz de la Sierra to San Francisco in just under 25h 50m. Your travel time can differ by up to . Airlines will cover a distance of 5414 mi.

  • What are the cheapest airlines flying from Santa Cruz de la Sierra to San Francisco round-trip?

    According to our current data, United Airlines ($324), Copa Airlines ($422), and Avianca ($706) offers the cheapest pricing from Santa Cruz de la Sierra to San Francisco. United Airlines is 60% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Santa Cruz de la Sierra to San Francisco that include hotel bookings?

    Yes. In addition to deals on Santa Cruz de la Sierra to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santa Cruz de la Sierra to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santa Cruz de la Sierra to San Francisco.

  • Can I find deals for business class flights from Santa Cruz de la Sierra to San Francisco?

    Yes. Cheapflights offers flight deals from Santa Cruz de la Sierra to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santa Cruz de la Sierra to San Francisco?

    Currently, January is the cheapest month in which you can book a flight from Santa Cruz de la Sierra to San Francisco (average of $276). Flying from Santa Cruz de la Sierra to San Francisco in June is currently the most expensive (average of $357). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Roseville
Santa Cruz
Livermore
South San Francisco
Turlock
Antioch
Watsonville
Manteca
Santa Clara
Sunnyvale
Hollister
Vacaville
Foster City
Vallejo
Burlingame
Redwood City
Union City
San Leandro
San Mateo
Lathrop

Browse thousands of different options on Cheapflights for your next trip

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Top 3 airlines flying from Santa Cruz de la Sierra to San Francisco

Discover the top 3 airlines that operate flights from Santa Cruz de la Sierra to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$324Average$835FlexibilityNo cancel feeOn-time69%
Copa AirlinesCheapest$422Average$1,080FlexibilityNo cancel feeOn-time70%
AviancaCheapest$706Average$1,087FlexibilityNo cancel feeOn-time71%

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