How long is the flight from Santa Cruz de la Sierra to San Francisco?

United Airlines can get you from Santa Cruz de la Sierra to San Francisco in just under 25h 51m. Your travel time can differ by up to . Airlines will cover a distance of 5414 mi.

In terms of precipitation, rainfall in San Francisco ranges from 0.0 - 4.4 inches per month. January is typically the wettest month, when rainfall can reach 4.4 in. July is typically the driest time to visit San Francisco when rainfall is around 0.0 in.

If weather is an important factor for your trip to San Francisco, use this chart to help with planning. For those seeking warmer temperatures, September is the ideal time of year to visit, when temperatures reach an average of 62.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 51.8 F).

What are the most popular airlines that fly from Santa Cruz de la Sierra to San Francisco?

Copa Airlines, United Airlines and Avianca are the most popular airlines when flying from Santa Cruz de la Sierra to San Francisco.

What is the cheapest time of day to fly from VVI to SFO?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Santa Cruz de la Sierra to San Francisco as you normally would.

Most accurate provider : When it comes to deals on Santa Cruz de la Sierra-San Francisco flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Santa Cruz de la Sierra-San Francisco flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Santa Cruz de la Sierra-San Francisco flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Santa Cruz de la Sierra-San Francisco flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santa Cruz de la Sierra-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

How can I find direct flights from Santa Cruz de la Sierra to San Francisco?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santa Cruz de la Sierra to San Francisco.

Can I find deals for business class flights from Santa Cruz de la Sierra to San Francisco?

Yes. Cheapflights offers flight deals from Santa Cruz de la Sierra to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$427+ Flights from Santa Cruz de la Sierra to San Francisco

Home Search by date Vacation packages Hotels Flight deals Car rental Travel tips & news

Find cheap flights from Santa Cruz de la Sierra to San Francisco with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Santa Cruz de la Sierra to San Francisco

Cheapest flights from Santa Cruz de la Sierra to San Francisco
Explore the most affordable flight options available from Santa Cruz de la Sierra to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

Thu 12/253:40 amVVI - SFO

2 stops22h 10mMultiple Airlines

Mon 12/2912:36 amSFO - VVI

1 stop18h 10mMultiple Airlines

Deal found 12/10

$1,156

Wed 12/173:40 amVVI - SFO

2 stops22h 10mAvianca

Tue 1/61:35 amSFO - VVI

2 stops21h 00mAvianca

Deal found 12/10

$1,388

Thu 12/1811:40 amVVI - SFO

1 stop15h 37mUnited Airlines

Wed 1/75:40 pmSFO - VVI

2 stops25h 10mUnited Airlines

Deal found 12/10

$1,645

Best flights from Santa Cruz de la Sierra to San Francisco
Discover carefully curated flight deals from Santa Cruz de la Sierra to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 12, 2025.

Thu 2/1911:44 amVVI - SFO

2 stops25h 51mUnited Airlines

Sun 2/225:00 amSFO - VVI

2 stops18h 44mUnited Airlines

Deal found 12/9

$820

Thu 12/253:40 amVVI - SFO

2 stops22h 10mMultiple Airlines

Mon 12/2912:36 amSFO - VVI

1 stop18h 10mMultiple Airlines

Deal found 12/10

$1,156

Mon 1/2611:44 amVVI - SFO

2 stops33h 35mUnited Airlines

Mon 2/211:18 amSFO - VVI

2 stops31h 32mUnited Airlines

Deal found 12/11

$1,246

Last-minute flights from Santa Cruz de la Sierra to San Francisco
Discover last-minute flight deals from Santa Cruz de la Sierra to San Francisco. Data last updated December 12, 2025 and is based on user searches.

Wed 12/173:40 amVVI - SFO

2 stops22h 10mAvianca

Tue 1/61:35 amSFO - VVI

2 stops21h 00mAvianca

Deal found 12/10

$1,388

Thu 12/1811:40 amVVI - SFO

1 stop15h 37mUnited Airlines

Wed 1/75:40 pmSFO - VVI

2 stops25h 10mUnited Airlines

Deal found 12/10

$1,645

Thu 12/253:40 amVVI - SFO

2 stops22h 10mMultiple Airlines

Mon 12/2912:36 amSFO - VVI

1 stop18h 10mMultiple Airlines

Deal found 12/10

$1,156

Wed 1/143:40 amVVI - SFO

2 stops22h 49mMultiple Airlines

Mon 2/2311:10 pmSFO - VVI

2 stops23h 25mMultiple Airlines

Deal found 12/10

$1,399

Mon 1/2611:44 amVVI - SFO

2 stops33h 35mUnited Airlines

Mon 2/211:18 amSFO - VVI

2 stops31h 32mUnited Airlines

Deal found 12/11

$1,246

One-way flights from Santa Cruz de la Sierra to San Francisco
Search for one-way flight options from Santa Cruz de la Sierra to San Francisco. Find affordable one-way fares based on user searches. Data last updated December 12, 2025.

Thu 1/293:40 amVVI - SFO

3 stops48h 01mMultiple Airlines

Deal found 12/10

$427

Thu 2/511:44 amVVI - SFO

2 stops25h 09mUnited Airlines

Deal found 12/10

$461

Thu 12/2511:40 amVVI - SFO

1 stop15h 37mCopa Airlines

Deal found 12/10

$467

Thu 2/53:40 amVVI - SFO

2 stops22h 10mAvianca

Deal found 12/11

$470

Tue 12/163:40 amVVI - SFO

2 stops22h 10mAvianca

Deal found 12/11

$553

Fri 2/65:25 amVVI - SFO

3 stops35h 07mLATAM Airlines

Deal found 12/9

$605

Tue 12/163:40 amVVI - SFO

3 stops45h 56mMultiple Airlines

Deal found 12/11

$625

Thu 12/2511:40 amVVI - SFO

2 stops38h 02mUnited Airlines

Deal found 12/10

$674

Find flight deals from Santa Cruz de la Sierra to San Francisco

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$820 (United Airlines)
One-way from	$427 (Kiwi.com)
Popular in	March
Cheapest in	September
Average price	$1,035

Provider with most accurate pricing for Santa Cruz de la Sierra Viru Viru Intl-San Francisco flight deals.

Search Deals

Provider most trusted by Cheapflights users for Santa Cruz de la Sierra Viru Viru Intl-San Francisco flights.

Search Deals

From Santa Cruz de la Sierra Viru Viru Intl to San Francisco

Search Deals

One-way flight from Santa Cruz de la Sierra Viru Viru Intl to San Francisco

Search Deals

Highest demand for flights based on searches. 16% potential increase in price ($170 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 2% potential price decrease ($25 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in December 2025

Search Deals

Cheapflights Fare Finder

Use the filters below to find and compare flights from Santa Cruz de la Sierra to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Santa Cruz de la SierraSan Francisco

VVI - SFO

VVISFO

Santa Cruz de la Sierra Viru Viru Intl

Thu 2/19

11:44 am-9:35 am

2 stops25h 51m

San Francisco

Sun 2/22

5:00 am-3:44 am

2 stops18h 44m

$820

Santa Cruz de la SierraSan Francisco

VVI - SFO

VVISFO

Santa Cruz de la Sierra Viru Viru Intl

Thu 12/25

3:40 am-9:50 pm

2 stops22h 10m

San Francisco

Mon 12/29

12:36 am-10:46 pm

1 stop18h 10m

$1,156

Santa Cruz de la SierraSan Francisco

VVI - SFO

VVISFO

Santa Cruz de la Sierra Viru Viru Intl

Mon 1/26

11:44 am-5:19 pm

2 stops33h 35m

San Francisco

Mon 2/2

11:18 am-10:50 pm

2 stops31h 32m

$1,246

Santa Cruz de la SierraSan Francisco

VVI - SFO

VVISFO

Santa Cruz de la Sierra Viru Viru Intl

Thu 1/29

3:40 am-11:41 pm

3 stops48h 01m

$427

Santa Cruz de la SierraSan Francisco

VVI - SFO

VVISFO

Santa Cruz de la Sierra Viru Viru Intl

Thu 2/5

11:44 am-11:12 pm

2 stops39h 28m

$461

Santa Cruz de la SierraSan Francisco

VVI - SFO

VVISFO

Santa Cruz de la Sierra Viru Viru Intl

Thu 2/5

11:44 am-11:20 pm

1 stop15h 36m

$467

Santa Cruz de la SierraSan Francisco

VVI - SFO

VVISFO

Santa Cruz de la Sierra Viru Viru Intl

Thu 12/25

11:40 am-11:17 pm

1 stop15h 37m

$467

Santa Cruz de la SierraSan Francisco

VVI - SFO

VVISFO

Santa Cruz de la Sierra Viru Viru Intl

Thu 2/5

3:40 am-9:50 pm

2 stops22h 10m

$470

Santa Cruz de la SierraSan Francisco

VVI - SFO

VVISFO

Santa Cruz de la Sierra Viru Viru Intl

Tue 12/16

3:40 am-9:50 pm

2 stops22h 10m

$553

Santa Cruz de la SierraSan Francisco

VVI - SFO

VVISFO

Santa Cruz de la Sierra Viru Viru Intl

Fri 2/6

5:25 am-12:32 pm

3 stops35h 07m

$605

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/10

Showing 1-10 of 11 results

Compare providers for flights from Santa Cruz de la Sierra to San Francisco

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santa Cruz de la Sierra to San Francisco in December.

Provider	Price Accuracy	Trust Score*
eDreams	Price Accuracy3 stars	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Santa Cruz de la Sierra-San Francisco flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Santa Cruz de la Sierra-San Francisco flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Santa Cruz de la Sierra-San Francisco flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Santa Cruz de la Sierra-San Francisco flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santa Cruz de la Sierra-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santa Cruz de la Sierra to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Santa Cruz de la Sierra with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santa Cruz de la Sierra to San Francisco

What is the cheapest month to book a flight from Santa Cruz de la Sierra to San Francisco?

Currently, May is the cheapest month in which you can book a flight from Santa Cruz de la Sierra to San Francisco (average of $323). Flying from Santa Cruz de la Sierra to San Francisco in March is currently the most expensive (average of $956). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing San Francisco

Read reviews from past customers who have flown Copa Airlines, United Airlines, and Avianca from Santa Cruz de la Sierra to San Francisco. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Copa Airlines

7.6

Good

1,558 reviews

Reviews

1 / 20

10.0

Excellent

Juan Pablo,Sep 2025

MEX - PTY

never better, had a very plesent trip to panama, cant say the same thing of my trip, from panama to santa cruz... it was very poor, unconftrable and boring

Copa Airlines

7.6

Good

1,558 reviews

Copa Airlines

7.6

Good

1,558 reviews

Reviews

1 / 20

10.0

Excellent

Juan Pablo,Sep 2025

MEX - PTY

never better, had a very plesent trip to panama, cant say the same thing of my trip, from panama to santa cruz... it was very poor, unconftrable and boring

United Airlines

7.4

Good

9,095 reviews

Copa Airlines

7.6

Good

1,558 reviews

Reviews

1 / 20

10.0

Excellent

Juan Pablo,Sep 2025

MEX - PTY

never better, had a very plesent trip to panama, cant say the same thing of my trip, from panama to santa cruz... it was very poor, unconftrable and boring

Avianca

6.6

Okay

2,479 reviews

Copa Airlines

7.6

Good

1,558 reviews

Reviews

1 / 20

10.0

Excellent

Juan Pablo,Sep 2025

MEX - PTY

never better, had a very plesent trip to panama, cant say the same thing of my trip, from panama to santa cruz... it was very poor, unconftrable and boring

Related info for your journey

How long is the flight from Santa Cruz de la Sierra to San Francisco?
United Airlines can get you from Santa Cruz de la Sierra to San Francisco in just under 25h 51m. Your travel time can differ by up to . Airlines will cover a distance of 5414 mi.
What are the cheapest airlines flying from Santa Cruz de la Sierra to San Francisco round-trip?
According to our current data, United Airlines ($324), Copa Airlines ($401), and Avianca ($706) offers the cheapest pricing from Santa Cruz de la Sierra to San Francisco. United Airlines is 62% cheaper than the average price of flights available within the next 90 days to this destination.
Can I find deals for flights from Santa Cruz de la Sierra to San Francisco that include hotel bookings?
Yes. In addition to deals on Santa Cruz de la Sierra to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Santa Cruz de la Sierra to San Francisco?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santa Cruz de la Sierra to San Francisco.
Can I find deals for business class flights from Santa Cruz de la Sierra to San Francisco?
Yes. Cheapflights offers flight deals from Santa Cruz de la Sierra to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Santa Cruz de la Sierra to San Francisco?
Currently, May is the cheapest month in which you can book a flight from Santa Cruz de la Sierra to San Francisco (average of $323). Flying from Santa Cruz de la Sierra to San Francisco in March is currently the most expensive (average of $956). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Roseville

South San Francisco

Santa Cruz

Livermore

Turlock

Manteca

Watsonville

Sunnyvale

Santa Clara

San Bruno

Redwood City

Daly City

Vallejo

Hollister

Foster City

Union City

Davis

San Ramon

Burlingame

Milpitas

Browse thousands of different options on Cheapflights for your next trip

Top 3 airlines flying from Santa Cruz de la Sierra to San Francisco

Airline	Cheapest	Average	Flexibility	On-time
United Airlines	Cheapest$324	Average$837	FlexibilityNo cancel fee	On-time69%
Copa Airlines	Cheapest$413	Average$1,122	FlexibilityNo cancel fee	On-time70%
Avianca	Cheapest$706	Average$1,067	FlexibilityNo cancel fee	On-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.

$427+ Cheap flights from Santa Cruz de la Sierra (VVI) to San Francisco (SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/29. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Santa Cruz de la Sierra to San Francisco with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Santa Cruz de la Sierra to San Francisco

Cheapest flights from Santa Cruz de la Sierra to San FranciscoExplore the most affordable flight options available from Santa Cruz de la Sierra to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

Explore the most affordable flight options available from Santa Cruz de la Sierra to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

Find flight deals from Santa Cruz de la Sierra to San Francisco

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Cheapflights Fare Finder

Use the filters below to find and compare flights from Santa Cruz de la Sierra to San Francisco that are best for you.

Compare providers for flights from Santa Cruz de la Sierra to San Francisco

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santa Cruz de la Sierra to San Francisco in December.

Best time to book a flight from Santa Cruz de la Sierra to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Santa Cruz de la Sierra with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Santa Cruz de la Sierra to San Francisco

What is the cheapest month to book a flight from Santa Cruz de la Sierra to San Francisco?

Reviews of airlines servicing San Francisco

Related info for your journey

Find useful and relevant information for your journey from Santa Cruz de la Sierra to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from Santa Cruz de la Sierra to San Francisco?

What are the cheapest airlines flying from Santa Cruz de la Sierra to San Francisco round-trip?

Can I find deals for flights from Santa Cruz de la Sierra to San Francisco that include hotel bookings?

How can I find direct flights from Santa Cruz de la Sierra to San Francisco?

Can I find deals for business class flights from Santa Cruz de la Sierra to San Francisco?

What is the cheapest month to book a flight from Santa Cruz de la Sierra to San Francisco?

Traveling to a place near San Francisco?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Santa Cruz de la Sierra to San Francisco

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from Santa Cruz de la Sierra to San Francisco

100% Free

Book with Flexibility

Travel Smart

Cheapest flights from Santa Cruz de la Sierra to San Francisco
Explore the most affordable flight options available from Santa Cruz de la Sierra to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.