Consider using Fast Track at FCO for a quicker security and passport control experience, especially if you're not flying business class.

Most accurate provider | eDreams 3 stars |
|---|---|
Most trusted provider | eDreams 3 stars |
Round-trip from | $506 |
Popular in | January |
Cheapest in | February |
Average price | $849 |
Good round-trip deal | $3,340 or less |
Good one-way deal | $837 or less |
Fly from
Fly to
Route
Depart
Return
Price
RomeSan Francisco
FCO - SFO
FCOSFO
Rome Fiumicino
Thu 2/26
4:40 pm-4:05 pm
1 stop32h 25m
San Francisco
Wed 3/4
4:35 pm-12:05 am
1 stop22h 30m
RomeSan Francisco
FCO - SFO
FCOSFO
Rome Fiumicino
Thu 2/26
10:40 am-8:42 pm
2 stops19h 02m
San Francisco
Wed 3/4
6:10 am-9:00 am
1 stop17h 50m
RomeSan Francisco
FCO - SFO
FCOSFO
Rome Fiumicino
Mon 1/12
6:50 pm-3:00 pm
1 stop29h 10m
San Francisco
Fri 1/30
8:40 pm-9:55 pm
1 stop16h 15m
RomeSan Francisco
FCO - SFO
FCOSFO
Rome Fiumicino
Fri 1/16
8:00 pm-3:00 pm
1 stop28h 00m
San Francisco
Tue 1/27
5:30 pm-7:40 pm
1 stop17h 10m
RomeSan Francisco
FCO - SFO
FCOSFO
Rome Fiumicino
Tue 1/13
8:25 pm-3:00 pm
1 stop27h 35m
San Francisco
Wed 1/28
4:30 pm-9:55 pm
2 stops20h 25m
RomeSan Francisco
FCO - SFO
FCOSFO
Rome Fiumicino
Sat 1/17
7:00 pm-3:00 pm
1 stop29h 00m
San Francisco
Sun 2/1
2:36 pm-7:55 pm
2 stops20h 19m
RomeSan Francisco
FCO - SFO
FCOSFO
Rome Fiumicino
Thu 1/15
8:10 pm-3:00 pm
1 stop27h 50m
San Francisco
Wed 1/28
4:30 pm-9:55 pm
2 stops20h 25m
RomeSan Francisco
FCO - SFO
FCOSFO
Rome Fiumicino
Fri 1/16
8:00 pm-3:00 pm
1 stop28h 00m
San Francisco
Mon 1/26
8:40 pm-11:25 am
1 stop29h 45m
RomeSan Francisco
CIA - SFO
CIASFO
Rome Ciampino
Sat 1/31
6:00 am-2:35 pm
2 stops17h 35m
San Francisco
Sat 2/7
4:40 pm-8:30 pm
2 stops18h 50m
RomeSan Francisco
CIA - SFO
CIASFO
Rome Ciampino
Fri 1/30
10:50 am-2:45 pm
3 stops36h 55m
San Francisco
Fri 2/6
2:40 pm-8:15 pm
2 stops20h 35m
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy2 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*1 star | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*2 stars |
The best time to book flights from Rome to San Francisco is 73 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
Currently, November is the cheapest month in which you can book a flight from Rome to San Francisco (average of $459). Flying from Rome to San Francisco in July is currently the most expensive (average of $700). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
One of the essential ways to save on airfare from Rome to San Francisco is to remain as flexible as possible. Flights that are in the afternoon tend to be the most expensive. A flight in the evening could potentially save you up to 29% on airfare.
Frankfurt am Main (FRA) – chosen by Cheapflights users on 50% of 1-stop itineraries from Rome to San Francisco on Cheapflights.
London (LHR) is the most affordable 1-stop option, with an average round-trip price of $777.
Flights via Frankfurt am Main (FRA) have the shortest average one-way travel time for 1-stop routes: 15h 20m.
Flights via Frankfurt am Main (FRA) offer the fastest connection on this route, with an average layover time of 1h 30m.
About 22% of weekly flights between Rome and San Francisco have experienced delays in the past year, with the average delay time being 135 minutes.
Historically, flights departing in the early afternoon are less likely to be delayed, whereas flights leaving in the morning tend to experience delays more often.
Saturday tends to have the lowest number of delays on this route, whereas Friday has historically faced a higher average of delays compared to other days of the week.
Over the last year, United Airlines have had the lowest number of delays on this route, with just 21% of flights being delayed.
Food
Boarding
Entertainment
Crew
Overall
Comfort
Reviews
Anonymous,Sep 2025
FRA - SFO
Food
Boarding
Entertainment
Crew
Overall
Comfort
Reviews
Anonymous,Sep 2025
FRA - SFO
Food
Boarding
Entertainment
Crew
Overall
Comfort
Reviews
Anonymous,Sep 2025
FRA - SFO
Food
Boarding
Entertainment
Crew
Overall
Comfort
Reviews
Anonymous,Sep 2025
FRA - SFO
Food
Boarding
Entertainment
Crew
Overall
Comfort
Reviews
Anonymous,Sep 2025
FRA - SFO
Food
Boarding
Entertainment
Crew
Overall
Comfort
Reviews
Anonymous,Sep 2025
FRA - SFO
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$565 | Average$766 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$580 | Average$769 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$629 | Average$818 | FlexibilityNo cancel fee | On-time76% | |
| Cheapest$636 | Average$814 | FlexibilityNo cancel fee | On-time70% |