What’s the top layover airport for flights from Fort Myers to San Francisco?

Chicago (ORD) – chosen by Cheapflights users on 50% of 1-stop itineraries from Fort Myers to San Francisco on Cheapflights.

Which airport typically offers the quickest layover for flights from Fort Myers to San Francisco?

Flights via Chicago (ORD) offer the fastest connection on this route, with an average layover time of 1h 24m.

What’s the fastest layover option from Fort Myers to San Francisco?

Flights via St. Louis (STL) have the shortest average one-way travel time for 1-stop routes: 9h 06m.

What’s the cheapest layover airport for flights from Fort Myers to San Francisco?

St. Louis (STL) is the most affordable 1-stop option, with an average round-trip price of $362.

How popular is this Fort Myers to San Francisco flight route?

Within the past month, 1 users have taken a look at flights from Fort Myers SW Florida Intl to San Francisco.

How long is the flight from Fort Myers to San Francisco?

There are many flights that can get you from Fort Myers to San Francisco in 8h 57m. Fly via JetBlue or United Airlines to get the fastest option. The distance between Fort Myers and San Francisco is about 2475 mi. Both multi-stop and nonstop flights can be found to your destination and back.

What are the cheapest airlines flying from Fort Myers to San Francisco round-trip?

Flying on American Airlines is currently your cheapest option to San Francisco, with prices starting at $204. Additional round-trip tickets that might be worth considering are offered by United Airlines and Delta, with the lowest prices starting at $256 and $256, respectively. American Airlines is currently priced 49% below the average price you’ll pay for this route.

In terms of precipitation, rainfall in San Francisco ranges from 0.0 - 4.4 inches per month. January is typically the wettest month, when rainfall can reach 4.4 in. July is typically the driest time to visit San Francisco when rainfall is around 0.0 in.

If weather is an important factor for your trip to San Francisco, use this chart to help with planning. For those seeking warmer temperatures, September is the ideal time of year to visit, when temperatures reach an average of 62.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 51.8 F).

What are the cheapest flights from Fort Myers to San Francisco?

While on average a flight from Fort Myers to San Francisco is generally $416, our data shows the cheapest flight currently is $273. When looking at the most popular route, (Fort Myers SW Florida Intl - San Francisco), you can expect to pay $272 for that flight.

What are the most popular airlines that fly from Fort Myers to San Francisco?

American Airlines, United Airlines and Delta are the most popular airlines when flying from Fort Myers to San Francisco.

Most accurate provider : When it comes to deals on Fort Myers-San Francisco flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Fort Myers-San Francisco flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Fort Myers-San Francisco flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Fort Myers-San Francisco flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Fort Myers-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Fort Myers to San Francisco that include hotel bookings?

Yes. In addition to deals on Fort Myers to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Fort Myers to San Francisco?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Fort Myers to San Francisco.

Can I find deals for business class flights from Fort Myers to San Francisco?

Yes. Cheapflights offers flight deals from Fort Myers to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$65+ Flights from Fort Myers to San Francisco

Home Search by date Vacation packages Hotels Flight deals Car rental Travel tips & news

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1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Fort Myers SW Florida Intl to San Francisco are usually found in July or May, booked 59 days in advance, depart on a Tuesday or Sunday and return on a Tuesday

Cheap flight deals from Fort Myers to San Francisco

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$285 (JetBlue)
One-way from	$65 (Priceline)
Popular in	December
Cheapest in	July
Average price	$482

Provider with most accurate pricing for Fort Myers SW Florida Intl-San Francisco flight deals.

Search Deals

Provider most trusted by Cheapflights users for Fort Myers SW Florida Intl-San Francisco flights.

Search Deals

From Fort Myers SW Florida Intl to San Francisco

Search Deals

One-way flight from Fort Myers SW Florida Intl to San Francisco

Search Deals

Highest demand for flights based on searches. 12% potential increase in price ($60 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 3% potential price decrease ($13 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in October 2025

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Find flight deals from Fort Myers to San Francisco

Cheapest flights from Fort Myers to San Francisco
Explore the most affordable flight options available from Fort Myers to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 29, 2025.

Sat 12/62:00 pmRSW - SFO

1 stop12h 59mJetBlue

Sat 12/139:16 pmSFO - RSW

1 stop10h 26mJetBlue

Deal found 10/28

$285

Sat 12/69:02 pmRSW - SFO

2 stops18h 03mBreeze Airways

Sat 12/1312:39 pmSFO - RSW

1 stop27h 03mBreeze Airways

Deal found 10/28

$288

Thu 12/115:05 pmRSW - SFO

1 stop8h 54mUnited Airlines

Sun 12/148:25 amSFO - RSW

Nonstop5h 03mUnited Airlines

Deal found 10/28

$295

Thu 12/45:38 pmRSW - SFO

1 stop8h 42mDelta

Tue 12/1610:30 pmSFO - RSW

1 stop8h 14mDelta

Deal found 10/29

$309

Thu 12/111:15 pmRSW - SFO

2 stops31h 20mMultiple Airlines

Sun 12/1411:33 pmSFO - RSW

1 stop14h 17mMultiple Airlines

Deal found 10/28

$312

Thu 12/47:15 pmRSW - SFO

1 stop8h 19mAmerican Airlines

Tue 12/1611:59 pmSFO - RSW

2 stops9h 33mAmerican Airlines

Deal found 10/27

$314

Sat 12/205:27 pmRSW - SFO

1 stop10h 05mAmerican Airlines

Sat 1/36:00 amSFO - RSW

1 stop7h 37mAmerican Airlines

Deal found 10/28

$319

Thu 12/188:30 amRSW - SFO

Nonstop6h 19mUnited Airlines

Tue 12/236:28 pmSFO - RSW

1 stop9h 15mUnited Airlines

Deal found 10/26

$320

Best flights from Fort Myers to San Francisco
Discover carefully curated flight deals from Fort Myers to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 29, 2025.

Thu 2/269:55 amRSW - SFO

1 stop13h 24mJetBlue

Mon 3/27:00 amSFO - RSW

1 stop12h 54mJetBlue

Deal found 10/26

$285

Wed 1/145:02 pmRSW - SFO

1 stop8h 57mUnited Airlines

Wed 1/218:25 amSFO - RSW

Nonstop5h 20mUnited Airlines

Deal found 10/28

$295

Sat 12/204:41 pmRSW - SFO

1 stop8h 27mDelta

Sun 1/410:45 pmSFO - RSW

1 stop9h 55mDelta

Deal found 10/29

$309

Thu 12/412:04 pmRSW - SFO

1 stop11h 35mDelta

Thu 12/115:55 amSFO - RSW

1 stop8h 15mDelta

Deal found 10/27

$309

Tue 11/187:00 amRSW - SFO

1 stop8h 10mUnited Airlines

Wed 12/310:40 pmSFO - RSW

1 stop9h 46mUnited Airlines

Deal found 10/27

$309

Thu 12/42:25 pmRSW - SFO

1 stop11h 48mDelta

Tue 12/167:15 amSFO - RSW

1 stop8h 29mDelta

Deal found 10/28

$309

Tue 11/183:48 pmRSW - SFO

1 stop10h 07mUnited Airlines

Tue 12/211:59 pmSFO - RSW

1 stop7h 51mUnited Airlines

Deal found 10/27

$309

Last-minute flights from Fort Myers to San Francisco
Discover last-minute flight deals from Fort Myers to San Francisco. Data last updated October 29, 2025 and is based on user searches.

Tue 11/114:45 pmRSW - SFO

1 stop22h 09mMultiple Airlines

Sat 11/158:55 pmSFO - RSW

2 stops38h 23mMultiple Airlines

Deal found 10/27

$356

Tue 11/112:57 pmRSW - SFO

1 stop10h 11mAmerican Airlines

Fri 11/1412:27 amSFO - RSW

1 stop9h 36mAmerican Airlines

Deal found 10/27

$369

Thu 11/135:37 pmRSW - SFO

1 stop9h 58mAmerican Airlines

Mon 11/179:00 amSFO - RSW

1 stop7h 52mAmerican Airlines

Deal found 10/27

$339

Thu 11/138:00 amRSW - SFO

1 stop9h 43mDelta

Sun 11/1612:30 amSFO - RSW

1 stop10h 03mDelta

Deal found 10/27

$349

Thu 11/131:13 pmRSW - SFO

1 stop10h 58mMultiple Airlines

Sat 11/296:12 pmSFO - RSW

1 stop13h 11mMultiple Airlines

Deal found 10/28

$363

Tue 11/188:00 amRSW - SFO

1 stop10h 16mUnited Airlines

Mon 12/112:43 amSFO - RSW

1 stop6h 59mUnited Airlines

Deal found 10/27

$309

Tue 11/186:44 amRSW - SFO

2 stops12h 17mAmerican Airlines

Mon 12/112:59 amSFO - RSW

1 stop6h 53mAmerican Airlines

Deal found 10/27

$314

Sat 11/226:24 pmRSW - SFO

1 stop8h 48mDelta

Fri 11/285:45 amSFO - RSW

1 stop8h 19mDelta

Deal found 10/28

$359

Mon 11/246:24 pmRSW - SFO

1 stop8h 48mDelta

Fri 11/285:45 amSFO - RSW

1 stop8h 19mDelta

Deal found 10/27

$334

One-way flights from Fort Myers to San Francisco
Search for one-way flight options from Fort Myers to San Francisco. Find affordable one-way fares based on user searches. Data last updated October 29, 2025.

Thu 11/131:13 pmRSW - SFO

1 stop10h 58mFrontier

Deal found 10/28

$65

Sat 1/101:19 pmRSW - SFO

2 stops21h 54mFrontier

Deal found 10/28

$131

Thu 12/185:40 pmRSW - SFO

1 stop9h 44mFrontier

Deal found 10/28

$135

Sat 12/68:29 pmRSW - SFO

2 stops38h 24mMultiple Airlines

Deal found 10/27

$137

Wed 12/319:53 amRSW - SFO

2 stops17h 31mFrontier

Deal found 10/28

$139

Thu 3/126:00 amRSW - SFO

1 stop10h 39mJetBlue

Deal found 10/28

$143

Mon 1/126:00 amRSW - SFO

1 stop10h 54mJetBlue

Deal found 10/28

$147

Sun 12/146:25 amRSW - SFO

2 stops28h 28mMultiple Airlines

Deal found 10/27

$148

Sat 1/109:00 amRSW - SFO

1 stop11h 59mAlaska Airlines

Deal found 10/28

$154

Wed 11/197:50 amRSW - SFO

1 stop9h 05mSouthwest

Deal found 10/28

$155

Tue 11/188:00 amRSW - SFO

3 stops40h 22mMultiple Airlines

Deal found 10/27

$163

Wed 11/265:45 pmRSW - SFO

1 stop9h 39mFrontier

Deal found 10/27

$167

Cheapflights Fare Finder

Use the filters below to find and compare flights from Fort Myers to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Fort MyersSan Francisco

RSW - SFO

RSWSFO

Fort Myers SW Florida Intl

Thu 2/26

9:55 am-8:19 pm

1 stop13h 24m

San Francisco

Mon 3/2

7:00 am-10:54 pm

1 stop12h 54m

$285

Fort MyersSan Francisco

RSW - SFO

RSWSFO

Fort Myers SW Florida Intl

Wed 1/14

5:02 pm-10:59 pm

1 stop8h 57m

San Francisco

Wed 1/21

8:25 am-4:45 pm

Nonstop5h 20m

$295

Fort MyersSan Francisco

RSW - SFO

RSWSFO

Fort Myers SW Florida Intl

Sat 12/20

4:41 pm-10:08 pm

1 stop8h 27m

San Francisco

Sun 1/4

10:45 pm-11:40 am

1 stop9h 55m

$309

Fort MyersSan Francisco

RSW - SFO

RSWSFO

Fort Myers SW Florida Intl

Thu 12/4

12:04 pm-8:39 pm

1 stop11h 35m

San Francisco

Thu 12/11

5:55 am-5:10 pm

1 stop8h 15m

$309

Fort MyersSan Francisco

RSW - SFO

RSWSFO

Fort Myers SW Florida Intl

Tue 11/18

7:00 am-12:10 pm

1 stop8h 10m

San Francisco

Wed 12/3

10:40 pm-11:26 am

1 stop9h 46m

$309

Fort MyersSan Francisco

RSW - SFO

RSWSFO

Fort Myers SW Florida Intl

Thu 12/4

2:25 pm-11:13 pm

1 stop11h 48m

San Francisco

Tue 12/16

7:15 am-6:44 pm

1 stop8h 29m

$309

Fort MyersSan Francisco

RSW - SFO

RSWSFO

Fort Myers SW Florida Intl

Tue 11/18

3:48 pm-10:55 pm

1 stop10h 07m

San Francisco

Tue 12/2

11:59 pm-10:50 am

1 stop7h 51m

$309

Fort MyersSan Francisco

RSW - SFO

RSWSFO

Fort Myers SW Florida Intl

Sat 12/6

2:00 pm-11:59 pm

1 stop12h 59m

$143

Fort MyersSan Francisco

RSW - SFO

RSWSFO

Fort Myers SW Florida Intl

Thu 3/19

9:55 am-8:19 pm

1 stop13h 24m

$143

Fort MyersSan Francisco

RSW - SFO

RSWSFO

Fort Myers SW Florida Intl

Fri 3/20

6:00 am-1:39 pm

1 stop10h 39m

$143

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/27

Showing 1-10 of 17 results

Compare providers for flights from Fort Myers to San Francisco

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Fort Myers to San Francisco in October.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy2 stars	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*1 star
eDreams	Price Accuracy3 stars	Trust Score*3 stars
JustAirTicket	Price Accuracy-	Trust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Fort Myers-San Francisco flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Fort Myers-San Francisco flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Fort Myers-San Francisco flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Fort Myers-San Francisco flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Fort Myers-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Fort Myers to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Fort Myers with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Fort Myers to San Francisco

Prices

How far ahead should I book a flight from Fort Myers to San Francisco?

To ensure you get the cheapest price possible for a flight from Fort Myers to San Francisco, you should look to book at least 59 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Fort Myers to San Francisco?

Currently, July is the cheapest month in which you can book a flight from Fort Myers to San Francisco (average of $136). Flying from Fort Myers to San Francisco in December is currently the most expensive (average of $286). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from RSW to SFO?

When flying from Fort Myers to San Francisco, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 39% versus a flight in the afternoon.

What is the cheapest day to fly from Fort Myers to San Francisco?

Travelers seeking maximum savings on their Fort Myers to San Francisco flight should consider departing on Monday afternoons when fares are most often at their lowest. Saturday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing San Francisco

Get a feel of what it's like to fly with Southwest, Delta, and United Airlines from Fort Myers to San Francisco by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Southwest

8.0

Very good

4,241 reviews

Reviews

1 / 20

8.0

Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.

Southwest

8.0

Very good

4,241 reviews

Southwest

8.0

Very good

4,241 reviews

Reviews

1 / 20

8.0

Excellent

Walter,Aug 2025

OAK - SAN

Delta

7.9

Good

7,992 reviews

Southwest

8.0

Very good

4,241 reviews

Reviews

1 / 20

8.0

Excellent

Walter,Aug 2025

OAK - SAN

United Airlines

7.4

Good

8,999 reviews

Southwest

8.0

Very good

4,241 reviews

Reviews

1 / 20

8.0

Excellent

Walter,Aug 2025

OAK - SAN

American Airlines

7.2

Good

11,032 reviews

Southwest

8.0

Very good

4,241 reviews

Reviews

1 / 20

8.0

Excellent

Walter,Aug 2025

OAK - SAN

Related info for your journey

How popular is this Fort Myers to San Francisco flight route?
Within the past month, 1 users have taken a look at flights from Fort Myers SW Florida Intl to San Francisco.
How long is the flight from Fort Myers to San Francisco?
There are many flights that can get you from Fort Myers to San Francisco in 8h 57m. Fly via JetBlue or United Airlines to get the fastest option. The distance between Fort Myers and San Francisco is about 2475 mi. Both multi-stop and nonstop flights can be found to your destination and back.
What are the cheapest airlines flying from Fort Myers to San Francisco round-trip?
Flying on American Airlines is currently your cheapest option to San Francisco, with prices starting at $204. Additional round-trip tickets that might be worth considering are offered by United Airlines and Delta, with the lowest prices starting at $256 and $256, respectively. American Airlines is currently priced 49% below the average price you’ll pay for this route.
What are the cheapest flights from Fort Myers to San Francisco?
While on average a flight from Fort Myers to San Francisco is generally $416, our data shows the cheapest flight currently is $273. When looking at the most popular route, (Fort Myers SW Florida Intl - San Francisco), you can expect to pay $272 for that flight.
Can I find deals for flights from Fort Myers to San Francisco that include hotel bookings?
Yes. In addition to deals on Fort Myers to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Fort Myers to San Francisco?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Fort Myers to San Francisco.
Can I find deals for business class flights from Fort Myers to San Francisco?
Yes. Cheapflights offers flight deals from Fort Myers to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Fort Myers to San Francisco?
Currently, July is the cheapest month in which you can book a flight from Fort Myers to San Francisco (average of $136). Flying from Fort Myers to San Francisco in December is currently the most expensive (average of $286). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Roseville

South San Francisco

Santa Cruz

Livermore

Turlock

Watsonville

Sunnyvale

Santa Clara

Antioch

Manteca

Vallejo

Hollister

Vacaville

San Bruno

Foster City

Redwood City

Union City

Fairfield

Burlingame

Lodi

Browse thousands of different options on Cheapflights for your next trip

Top 4 airlines flying from Fort Myers to San Francisco

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$204	Average$369	FlexibilityNo cancel fee	On-time71%
United Airlines	Cheapest$256	Average$452	FlexibilityNo cancel fee	On-time69%
Delta	Cheapest$256	Average$336	FlexibilityNo cancel fee	On-timeN/A
Southwest	Cheapest$264	Average$458	FlexibilityNo cancel fee	On-time63%

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$65+ Cheap flights from Fort Myers to San Francisco (RSW - SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/13. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Fort Myers to San Francisco with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from Fort Myers SW Florida Intl to San Francisco are usually found in July or May, booked 59 days in advance, depart on a Tuesday or Sunday and return on a Tuesday

Cheap flight deals from Fort Myers to San Francisco

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Fort Myers to San Francisco

Cheapest flights from Fort Myers to San FranciscoExplore the most affordable flight options available from Fort Myers to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 29, 2025.

Explore the most affordable flight options available from Fort Myers to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 29, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Fort Myers to San Francisco that are best for you.

Compare providers for flights from Fort Myers to San Francisco

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Fort Myers to San Francisco in October.

Best time to book a flight from Fort Myers to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Fort Myers with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Fort Myers to San Francisco

How far ahead should I book a flight from Fort Myers to San Francisco?

What is the cheapest month to book a flight from Fort Myers to San Francisco?

What is the cheapest time of day to fly from RSW to SFO?

What is the cheapest day to fly from Fort Myers to San Francisco?

What’s the top layover airport for flights from Fort Myers to San Francisco?

What’s the fastest layover option from Fort Myers to San Francisco?

What’s the fastest layover option from Fort Myers to San Francisco?

Which airport typically offers the quickest layover for flights from Fort Myers to San Francisco?

Reviews of airlines servicing San Francisco

Get a feel of what it's like to fly with Southwest, Delta, and United Airlines from Fort Myers to San Francisco by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Fort Myers to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How popular is this Fort Myers to San Francisco flight route?

How long is the flight from Fort Myers to San Francisco?

What are the cheapest airlines flying from Fort Myers to San Francisco round-trip?

What are the cheapest flights from Fort Myers to San Francisco?

Can I find deals for flights from Fort Myers to San Francisco that include hotel bookings?

How can I find direct flights from Fort Myers to San Francisco?

Can I find deals for business class flights from Fort Myers to San Francisco?

What is the cheapest month to book a flight from Fort Myers to San Francisco?

Traveling to a place near San Francisco?

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Fort Myers to San Francisco

See prices for flight routes from nearby airports that may be better suited for you.

Top 4 airlines flying from Fort Myers to San Francisco

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Cheapest flights from Fort Myers to San Francisco
Explore the most affordable flight options available from Fort Myers to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 29, 2025.