HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
San Francisco

$149+ Cheap flights from Detroit to San Francisco (DTT - SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/4. Fares are subject to change and may not be available on all flights or dates of travel.
DTT — SFO
Dec 6 — Dec 131
Sat 12/6
Sat 12/13
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Detroit to San Francisco with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Detroit All airports to San Francisco are usually found in July or May, booked 37 days in advance, depart on a Friday or Thursday and return on a Wednesday

Find flight deals from Detroit to San Francisco

Cheapest flights from Detroit to San Francisco
Explore the most affordable flight options available from Detroit to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 6, 2025.

This Kiwi.com deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/186:29 pmDTW - SFO
2 stops29h 53mFrontier
Fri 11/216:32 amSFO - DTW
1 stop8h 35mFrontier
Deal found 11/4$308
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/57:16 amDTW - SFO
1 stop9h 18mAmerican Airlines
Sat 12/612:25 amSFO - DTW
1 stop7h 49mAmerican Airlines
Deal found 11/3$309
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1211:03 amDTW - SFO
1 stop28h 57mMultiple Airlines
Wed 11/198:55 pmSFO - DTW
1 stop12h 27mMultiple Airlines
Deal found 11/5$310
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/187:50 amDTW - SFO
1 stop7h 44mFrontier
Thu 1/14:07 pmSFO - DTW
1 stop16h 18mFrontier
Deal found 11/5$311
This Trip.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/2611:03 amDTW - SFO
2 stops24h 05mMultiple Airlines
Tue 12/26:00 amSFO - DTW
2 stops27h 44mMultiple Airlines
Deal found 11/3$312
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/157:00 amDTW - SFO
1 stop17h 11mMultiple Airlines
Tue 11/188:02 amSFO - DTW
2 stops20h 41mMultiple Airlines
Deal found 11/5$313
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/126:29 pmDTW - SFO
2 stops20h 46mFrontier
Mon 11/176:34 amSFO - DTW
1 stop6h 45mFrontier
Deal found 11/5$314
This United Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/89:10 amDTW - SFO
1 stop9h 06mUnited Airlines
Sat 12/1311:25 amSFO - DTW
Nonstop4h 39mUnited Airlines
Deal found 11/4$315
This CheapOair deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/135:14 pmDTW - SFO
1 stop24h 26mFrontier
Sun 11/166:34 amSFO - DTW
1 stop10h 46mFrontier
Deal found 11/4$317
This Kiwi.com deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/259:01 amDTW - SFO
1 stop13h 22mMultiple Airlines
Sun 11/304:54 pmSFO - DTW
1 stop24h 54mMultiple Airlines
Deal found 11/4$319
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/309:46 amDTW - SFO
1 stop13h 44mMultiple Airlines
Sun 1/49:56 pmSFO - DTW
1 stop18h 55mMultiple Airlines
Deal found 11/5$320
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/125:20 pmDTW - SFO
1 stop10h 04mMultiple Airlines
Tue 12/3011:59 pmSFO - DTW
1 stop7h 26mMultiple Airlines
Deal found 11/5$321

Cheap flight deals from Detroit to San Francisco

Discover tips and strategies to find the most affordable flight options for your journey from Detroit (DTT) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 6, 2025.

Most accurate provider

Mytrip
3 stars

Most trusted provider

Mytrip
3 stars

Round-trip from

$307
(Kiwi.com)

One-way from

$149
(JetBlue)

Popular in

January

Cheapest in

July

Average price

$529

Good round-trip deal

$428 or less

Good one-way deal

$253 or less
Provider with most accurate pricing for Detroit (DTT)-San Francisco flight deals.
Search Deals
Provider most trusted by Cheapflights users for Detroit (DTT)-San Francisco flights.
Search Deals
From Detroit (DTT) to San Francisco
Search Deals
One-way flight from Detroit (DTT) to San Francisco
Search Deals
Highest demand for flights based on searches. 21% potential increase in price ($127 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($15 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals
Price to beat on a round-trip flight from Detroit (DTT) to San Francisco.
Search Deals
Price to beat on a one-way flight from Detroit (DTT) to San Francisco.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Detroit to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
Use the filters below to find and compare flights from Detroit to San Francisco that are best for you.

Fly from

Detroit

Fly to

San Francisco

Route

Depart

Return

Price

DetroitSan Francisco

DTW - SFO

DTWSFO

Detroit Metropolitan Wayne County

Sat 1/24

5:15 pm-11:03 pm

1 stop8h 48m

San Francisco

Sat 1/31

6:18 pm-4:19 pm

1 stop19h 01m

$308

DetroitSan Francisco

DTW - SFO

DTWSFO

Detroit Metropolitan Wayne County

Wed 11/26

4:30 pm-8:57 pm

1 stop7h 27m

San Francisco

Tue 12/2

10:45 pm-10:02 am

1 stop8h 17m

$309

DetroitSan Francisco

DTW - SFO

DTWSFO

Detroit Metropolitan Wayne County

Thu 1/22

5:15 pm-11:03 pm

1 stop8h 48m

San Francisco

Sun 1/25

11:36 am-4:19 pm

2 stops25h 43m

$362

DetroitSan Francisco

DTW - SFO

DTWSFO

Detroit Metropolitan Wayne County

Fri 1/23

6:50 am-2:20 pm

2 stops10h 30m

San Francisco

Sun 1/25

9:10 am-10:10 pm

2 stops10h 00m

$368

DetroitSan Francisco

DTW - SFO

DTWSFO

Detroit Metropolitan Wayne County

Fri 12/12

8:00 am-3:20 pm

2 stops10h 20m

San Francisco

Tue 12/16

10:35 am-10:40 pm

2 stops9h 05m

$368

DetroitSan Francisco

DTW - SFO

DTWSFO

Detroit Metropolitan Wayne County

Fri 12/5

7:05 am-9:30 am

Nonstop5h 25m

San Francisco

Sun 12/7

11:25 am-7:04 pm

Nonstop4h 39m

$389

DetroitSan Francisco

DTW - SFO

DTWSFO

Detroit Metropolitan Wayne County

Mon 1/26

7:10 am-9:31 am

Nonstop5h 21m

San Francisco

Sun 2/1

4:10 pm-11:48 pm

Nonstop4h 38m

$389

DetroitSan Francisco

DTW - SFO

DTWSFO

Detroit Metropolitan Wayne County

Thu 12/11

7:05 am-9:30 am

Nonstop5h 25m

San Francisco

Sun 12/14

11:25 am-7:04 pm

Nonstop4h 39m

$389

DetroitSan Francisco

DTW - SFO

DTWSFO

Detroit Metropolitan Wayne County

Fri 12/19

7:10 am-9:35 am

Nonstop5h 25m

San Francisco

Sun 12/28

11:05 pm-10:33 am

1 stop8h 28m

$394

DetroitSan Francisco

DTW - SFO

DTWSFO

Detroit Metropolitan Wayne County

Thu 1/22

9:00 am-3:35 pm

1 stop9h 35m

San Francisco

Sun 1/25

4:10 pm-11:48 pm

Nonstop4h 38m

$399

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/6

Showing 1-10 of 22 results
1
2
3

Compare providers for flights from Detroit to San Francisco

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Detroit to San Francisco in November.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars
MytripPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Detroit-San Francisco flights, users find the pricing of Mytrip to be most consistent on Cheapflights vs. Mytrip Users can find the same prices on Detroit-San Francisco flight deals on Cheapflights vs. Mytrip >95% of the time. Price accuracy is based on data collected from Detroit-San Francisco flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Detroit-San Francisco flights, Cheapflights users trust Mytrip the most. Mytrip has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Detroit-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Detroit to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Detroit with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Detroit to San Francisco

How far ahead should I book a flight from Detroit to San Francisco?

Use this chart to determine the optimal time to book a round-trip flight from Detroit to San Francisco. Price data was last updated on October 31, 2025.

Booking 37 days in advance of your planned departure date is, on average, the best time to get cheap flights from Detroit to San Francisco. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Detroit to San Francisco?

Currently, March is the cheapest month in which you can book a flight from Detroit to San Francisco (average of $130). Flying from Detroit to San Francisco in August is currently the most expensive (average of $256). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DTT to SFO?

Find hourly flight availability from Detroit to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 6, 2025.

It’s optimal to fly from Detroit to San Francisco in the afternoon. By choosing this option you can save up to 40% on the cost of your flight, compared to a flight at noon.

What is the cheapest day to fly from Detroit to San Francisco?

Use this chart to determine the cheapest time to fly round-trip from Detroit to San Francisco. Price data was last updated on November 2, 2025.

Travelers seeking maximum savings on their Detroit to San Francisco flight should consider departing on Friday evenings when fares are most often at their lowest. Monday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Detroit to San Francisco

Explore weekly flight availability from Detroit to San Francisco. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated November 6, 2025.

The most flights from DTT to SFO are scheduled on a Thursday (12 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (1 on average).

How much does it cost to fly round-trip from Detroit to San Francisco?

What’s the top layover airport for flights from Detroit to San Francisco?

Share of 1-stop round-trip flights from Detroit to San Francisco chosen by Cheapflights users in the past 12 months, using the same layover each way.

Chicago (ORD) – chosen by Cheapflights users on 50% of 1-stop itineraries from Detroit to San Francisco on Cheapflights.

What’s the cheapest layover airport for flights from Detroit to San Francisco?

Average round-trip fare for 1-stop flights from Detroit to San Francisco, chosen by Cheapflights users in the past 12 months, with the same layover each way.

Denver (DEN) is the most affordable 1-stop option, with an average round-trip price of $155.

What’s the fastest layover option from Detroit to San Francisco?

Shortest average travel time for 1-stop one-way flights from Detroit to San Francisco, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.

Flights via Chicago (ORD) have the shortest average one-way travel time for 1-stop routes: 7h 20m.

Which airport typically offers the quickest layover for flights from Detroit to San Francisco?

Average layover duration for 1-stop one-way flights from Detroit to San Francisco, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.

Flights via Chicago (ORD) offer the fastest connection on this route, with an average layover time of 1h 11m.

Reviews of airlines servicing San Francisco

Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated November 6, 2025.
Read reviews from past customers who have flown Southwest, Delta, and United Airlines from Detroit to San Francisco. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,241 reviews

Comfort

8.0

Overall

8.0

Crew

8.6

Boarding

8.1

Food

7.0

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Southwest
8.0
Very good
4,241 reviews
Southwest
8.0
Very good
4,241 reviews

Comfort

8.0

Overall

8.0

Crew

8.6

Boarding

8.1

Food

7.0

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Delta
7.9
Good
8,001 reviews
Southwest
8.0
Very good
4,241 reviews

Comfort

8.0

Overall

8.0

Crew

8.6

Boarding

8.1

Food

7.0

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
United Airlines
7.4
Good
9,007 reviews
Southwest
8.0
Very good
4,241 reviews

Comfort

8.0

Overall

8.0

Crew

8.6

Boarding

8.1

Food

7.0

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
American Airlines
7.2
Good
11,040 reviews
Southwest
8.0
Very good
4,241 reviews

Comfort

8.0

Overall

8.0

Crew

8.6

Boarding

8.1

Food

7.0

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Frontier
5.8
Fair
3,115 reviews
Southwest
8.0
Very good
4,241 reviews

Comfort

8.0

Overall

8.0

Crew

8.6

Boarding

8.1

Food

7.0

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.

Related info for your journey

Find useful and relevant information for your journey from Detroit to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Detroit to San Francisco?

    You will need to book a flight from Detroit All airports to San Francisco if you want to fly from Detroit to San Francisco. At least 8 different airlines have flights from All airports (DTT) to San Francisco (SFO) on a regular basis. There are 7 flights to San Francisco from the Detroit airport per day. If you manage to book one that is nonstop, then you can expect the flight time from DTT to SFO to be around 5h 08m.

  • How long is the flight from Detroit to San Francisco?

    Alaska Airlines, United Airlines, and Southwest can get you from Detroit to San Francisco in just under 7h 27m. Your travel time can differ by up to 3h 03m. The distance from Detroit to San Francisco is about 2072 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Detroit to San Francisco round-trip?

    Currently priced at $101, Spirit Airlines will fly you from Detroit to San Francisco and back. In addition to Spirit Airlines, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from Sun Country Air and Frontier - these airlines can fly you to your destination from $128 and $130, respectively. Spirit Airlines is 79% cheaper than the average price of flights available within the next 90 days to this destination.

  • What are the most reliable airlines from Detroit to San Francisco?

    No one likes to see their flight delayed. When booking a flight from Detroit to San Francisco consider choosing China Eastern (100%), Virgin Atlantic (92%) or Korean Air (89%) as they are the most reliable in getting you off to your destination on time.

  • What are the cheapest flights from Detroit to San Francisco?

    While on average a flight from Detroit to San Francisco is generally $646, our data shows the cheapest flight currently is $158. When looking at the most popular route, (Detroit Metropolitan Wayne County - San Francisco), you can expect to pay $144 for that flight.

  • Can I find deals for flights from Detroit to San Francisco that include hotel bookings?

    Yes. In addition to deals on Detroit to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Detroit to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Detroit to San Francisco.

  • Can I find deals for business class flights from Detroit to San Francisco?

    Yes. Cheapflights offers flight deals from Detroit to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Detroit to San Francisco?

    Currently, March is the cheapest month in which you can book a flight from Detroit to San Francisco (average of $130). Flying from Detroit to San Francisco in August is currently the most expensive (average of $256). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Roseville
South San Francisco
Santa Cruz
Livermore
Turlock
Manteca
Watsonville
Sunnyvale
Santa Clara
Vallejo
Hollister
San Bruno
Foster City
Redwood City
Union City
Burlingame
Lodi
San Mateo
Vacaville
Lathrop

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Detroit to San Francisco

See prices for flight routes from nearby airports that may be better suited for you.
O'Hare Intl to Las Vegas flights
O'Hare Intl to Los Angeles flights
O'Hare Intl to San Francisco flights
Detroit to Las Vegas flights
Detroit to Los Angeles flights
Midway to Las Vegas flights
O'Hare Intl to San Diego flights
Midway to Los Angeles flights
O'Hare Intl to Santa Ana flights
O'Hare Intl to Ontario flights
O'Hare Intl to Palm Springs flights
Detroit to San Francisco flights
Midway to San Francisco flights
Detroit to San Diego flights
O'Hare Intl to San Jose flights
Detroit to Santa Ana flights
O'Hare Intl to Reno flights
Detroit to Ontario flights
O'Hare Intl to Burbank flights
Midway to San Diego flights
O'Hare Intl to Sacramento flights
Rockford to Las Vegas flights
Grand Rapids to Las Vegas flights
Detroit to Burbank flights
Midway to Ontario flights
Midway to Santa Ana flights
O'Hare Intl to Oakland flights
Grand Rapids to Los Angeles flights
Midway to Palm Springs flights
Midway to San Jose flights
South Bend to Las Vegas flights
Detroit to Palm Springs flights
Detroit to Reno flights
Detroit to Sacramento flights
Flint to Las Vegas flights
O'Hare Intl to Santa Barbara flights
O'Hare Intl to Long Beach flights
Detroit to San Jose flights
Grand Rapids to Ontario flights
Traverse City to Las Vegas flights
Midway to Burbank flights
Midway to Reno flights
South Bend to Los Angeles flights
Grand Rapids to San Diego flights
Traverse City to Los Angeles flights
Grand Rapids to Santa Ana flights
Midway to Sacramento flights
Grand Rapids to San Francisco flights
Midway to Oakland flights
Midway to Long Beach flights

Top 8 airlines flying from Detroit to San Francisco

Discover the top 8 airlines that operate flights from Detroit to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$101Average$284FlexibilityNo cancel feeOn-time65%
Sun Country AirCheapest$128Average$310FlexibilityNo cancel feeOn-time83%
FrontierCheapest$130Average$247FlexibilityNo cancel feeOn-time62%
JetBlueCheapest$267Average$298FlexibilityNo cancel feeOn-time62%
United AirlinesCheapest$289Average$435FlexibilityNo cancel feeOn-time69%
DeltaCheapest$289Average$546FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$306Average$505FlexibilityNo cancel feeOn-time63%
American AirlinesCheapest$308Average$413FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.