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$547+ Cheap flights from Panama City (PTY) to Rome (ROM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/23. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — ROM
Apr 9 — Apr 161
Thu 4/9
Thu 4/16
1 adult, Economy
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Cheap flight deals from Panama City to Rome

Cheapest flights from Panama City to Rome
Explore the most affordable flight options available from Panama City to Rome. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 10, 2026.

This Booking.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2210:20 pm
PTY
-
FCO
1 stop37h 05m
Turkish Airlines
Wed 4/297:05 am
FCO
-
PTY
1 stop20h 20m
Turkish Airlines
Deal found 3/8$696
This Booking.com deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/2010:20 pm
PTY
-
FCO
1 stop32h 45m
Turkish Airlines
Mon 4/277:05 am
FCO
-
PTY
1 stop20h 20m
Turkish Airlines
Deal found 3/6$698
This Turkish Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Turkish Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/2710:20 pm
PTY
-
FCO
1 stop32h 45m
Turkish Airlines
Mon 6/17:05 am
FCO
-
PTY
1 stop20h 20m
Turkish Airlines
Deal found 3/5$730
This Air France deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/292:27 pm
PTY
-
FCO
1 stop37h 23m
Multiple Airlines
Sun 5/107:45 pm
FCO
-
PTY
1 stop28h 05m
Multiple Airlines
Deal found 3/6$736
This FlightHub deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/268:05 pm
PTY
-
FCO
1 stop39h 20m
Turkish Airlines
Sun 6/283:10 pm
FCO
-
PTY
1 stop36h 15m
Turkish Airlines
Deal found 3/10$772
This Air France deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/152:27 pm
PTY
-
FCO
1 stop37h 23m
Multiple Airlines
Wed 5/1310:35 am
FCO
-
PTY
1 stop37h 15m
Multiple Airlines
Deal found 3/6$783
This KLM deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/316:50 pm
PTY
-
FCO
1 stop20h 55m
Multiple Airlines
Thu 6/46:05 am
FCO
-
PTY
1 stop20h 40m
Multiple Airlines
Deal found 3/7$785
This Trip.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/48:25 pm
PTY
-
FCO
1 stop14h 00m
Air Europa
Mon 5/1110:30 am
FCO
-
PTY
1 stop15h 10m
Air Europa
Deal found 3/8$788
This KLM deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/186:50 pm
PTY
-
FCO
1 stop31h 45m
KLM
Sun 5/317:45 pm
FCO
-
PTY
1 stop28h 05m
KLM
Deal found 3/5$795

Find flight deals from Panama City to Rome

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Rome (ROM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 10, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$696
(Booking.com)

One-way from

$547
(Kiwi.com)

Popular in

January

Cheapest in

April

Average price

$880
Provider with most accurate pricing for Panama City Tocumen Intl-Rome (ROM) flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Rome (ROM) flights.
Search Deals
From Panama City Tocumen Intl to Rome (ROM)
Search Deals
One-way flight from Panama City Tocumen Intl to Rome (ROM)
Search Deals
Highest demand for flights based on searches. 7% potential increase in price ($72 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($17 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Rome that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 10, 2026.
Use the filters below to find and compare flights from Panama City to Rome that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CityRome

PTY - FCO

PTYFCO

Panama City Tocumen Intl

Mon 4/27

10:20 pm-2:05 pm

1 stop32h 45m

Rome Fiumicino

Mon 6/1

7:05 am-8:25 pm

1 stop20h 20m

$730

Panama CityRome

PTY - FCO

PTYFCO

Panama City Tocumen Intl

Wed 4/29

10:20 pm-11:35 pm

1 stop18h 15m

Rome Fiumicino

Sun 5/10

3:10 pm-6:30 pm

2 stops34h 20m

$862

Panama CityRome

PTY - FCO

PTYFCO

Panama City Tocumen Intl

Mon 4/27

9:45 am-10:55 am

1 stop18h 10m

Rome Fiumicino

Mon 6/1

3:20 pm-7:31 pm

2 stops35h 11m

$918

Panama CityRome

PTY - FCO

PTYFCO

Panama City Tocumen Intl

Mon 4/13

10:55 pm-7:55 am

2 stops26h 00m

Rome Fiumicino

Sat 5/9

9:45 am-4:04 am

2 stops25h 19m

$918

Panama CityRome

PTY - FCO

PTYFCO

Panama City Tocumen Intl

Tue 5/19

9:45 am-9:15 am

2 stops40h 30m

Rome Fiumicino

Fri 5/29

10:20 am-7:31 pm

2 stops40h 11m

$922

Panama CityRome

PTY - FCO

PTYFCO

Panama City Tocumen Intl

Sun 5/10

9:45 am-10:55 am

1 stop18h 10m

Rome Fiumicino

Mon 5/25

11:30 am-7:31 pm

2 stops39h 01m

$926
Quickest round-trip

Panama CityRome

PTY - FCO

PTYFCO

Panama City Tocumen Intl

Sat 4/25

9:45 am-10:55 am

1 stop18h 10m

Rome Fiumicino

Sat 5/16

9:45 am-4:04 am

2 stops25h 19m

$927

Panama CityRome

PTY - FCO

PTYFCO

Panama City Tocumen Intl

Mon 3/23

6:45 pm-11:10 pm

1 stop22h 25m

Rome Fiumicino

Tue 3/31

7:45 pm-4:50 pm

1 stop28h 05m

$965
Cheapest one-way

Panama CityRome

PTY - FCO

PTYFCO

Panama City Tocumen Intl

Thu 4/23

8:25 pm-7:30 pm

2 stops40h 05m

$547

Panama CityRome

PTY - FCO

PTYFCO

Panama City Tocumen Intl

Tue 8/11

5:55 pm-6:35 pm

2 stops17h 40m

$620

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/6

Showing 1-10 of 13 resultsSorted by cheapest first
1
2
  • Most accurate provider: When it comes to deals on Panama City-Rome flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-Rome flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-Rome flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City-Rome flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Rome flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Rome

Have a flexible travel schedule? Discover the best time to fly to Rome from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Rome

How far ahead should I book a flight from Panama City to Rome?

Use this chart to determine the optimal time to book a round-trip flight from Panama City to Rome. Price data was last updated on March 6, 2026.

The price you pay for your flight from Panama City to Rome may vary depending on when you book. For the best chance of a lower fare, look to book 52 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Panama City to Rome?

Currently, August is the cheapest month in which you can book a flight from Panama City to Rome (average of $453). Flying from Panama City to Rome in January is currently the most expensive (average of $774). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Panama City to Rome?

What’s the top layover airport for flights from Panama City to Rome?

Share of 1-stop round-trip flights from Panama City to Rome chosen by Cheapflights users in the past 12 months, using the same layover each way.

Amsterdam (AMS) – chosen by Cheapflights users on 56% of 1-stop itineraries from Panama City to Rome on Cheapflights.

What’s the cheapest layover airport for flights from Panama City to Rome?

Average round-trip fare for 1-stop flights from Panama City to Rome, chosen by Cheapflights users in the past 12 months, with the same layover each way.

Madrid (MAD) is the most affordable 1-stop option, with an average round-trip price of $1,113.

What’s the fastest layover option from Panama City to Rome?

Shortest average travel time for 1-stop one-way flights from Panama City to Rome, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.

Flights via Madrid (MAD) have the shortest average one-way travel time for 1-stop routes: 14h 00m.

Which airport typically offers the quickest layover for flights from Panama City to Rome?

Average layover duration for 1-stop one-way flights from Panama City to Rome, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.

Flights via Madrid (MAD) offer the fastest connection on this route, with an average layover time of 2h 13m.

Reviews of airlines servicing Rome

Get insights into the airlines that provide service to Rome. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Rome. Reviews last updated March 10, 2026.
Read reviews from past customers who have flown KLM,Air France, andTurkish Airlines from Panama City to Rome. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
KLM
7.8
Good
1,468 reviews

Boarding

7.8

Comfort

7.6

Crew

8.4

Food

7.3

Entertainment

7.1

Overall

7.8

Reviews

1 / 20
2.0
Mediocre

Anonymous,Feb 2026

EZE - SCL

It was a short trip The aeroplane was delay I arrived in Chile late and I lost my fly with Qantas
KLM
7.8
Good
1,468 reviews
KLM
7.8
Good
1,468 reviews

Boarding

7.8

Comfort

7.6

Crew

8.4

Food

7.3

Entertainment

7.1

Overall

7.8

Reviews

1 / 20
2.0
Mediocre

Anonymous,Feb 2026

EZE - SCL

It was a short trip The aeroplane was delay I arrived in Chile late and I lost my fly with Qantas
Air France
7.4
Good
1,543 reviews
KLM
7.8
Good
1,468 reviews

Boarding

7.8

Comfort

7.6

Crew

8.4

Food

7.3

Entertainment

7.1

Overall

7.8

Reviews

1 / 20
2.0
Mediocre

Anonymous,Feb 2026

EZE - SCL

It was a short trip The aeroplane was delay I arrived in Chile late and I lost my fly with Qantas
Turkish Airlines
7.3
Good
4,249 reviews
KLM
7.8
Good
1,468 reviews

Boarding

7.8

Comfort

7.6

Crew

8.4

Food

7.3

Entertainment

7.1

Overall

7.8

Reviews

1 / 20
2.0
Mediocre

Anonymous,Feb 2026

EZE - SCL

It was a short trip The aeroplane was delay I arrived in Chile late and I lost my fly with Qantas
Iberia
7.0
Good
3,133 reviews
KLM
7.8
Good
1,468 reviews

Boarding

7.8

Comfort

7.6

Crew

8.4

Food

7.3

Entertainment

7.1

Overall

7.8

Reviews

1 / 20
2.0
Mediocre

Anonymous,Feb 2026

EZE - SCL

It was a short trip The aeroplane was delay I arrived in Chile late and I lost my fly with Qantas
Air Europa
6.9
Okay
593 reviews
KLM
7.8
Good
1,468 reviews

Boarding

7.8

Comfort

7.6

Crew

8.4

Food

7.3

Entertainment

7.1

Overall

7.8

Reviews

1 / 20
2.0
Mediocre

Anonymous,Feb 2026

EZE - SCL

It was a short trip The aeroplane was delay I arrived in Chile late and I lost my fly with Qantas

Related info for your journey

Find useful and relevant information for your journey from Panama City to Rome. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to Rome?

    Located just 11.4 mi from the city center, Panama City Tocumen Intl is the airport most travelers will use when flying to Rome from Panama City. Booking flights from Tocumen Intl (PTY) to Rome should be relatively easy as there are 0 daily outbound flights to Rome from 3 different airlines.

  • How long is the flight from Panama City to Rome?

    Airlines like United Airlines fly from Panama City to Rome in about 39h 15m. The time it takes to get you to your destination can typically vary by up to . Panama City and Rome are separated by a distance of 5881 mi.

  • What are the cheapest airlines flying from Panama City to Rome round-trip?

    Flying on Air Europa is currently your cheapest option to Rome, with prices starting at $679. Additional round-trip tickets that might be worth considering are offered by Turkish Airlines and Air France, with the lowest prices starting at $690 and $818, respectively. You may be able to fly from Panama City to Rome for 22% less than the average price by searching for these airlines.

  • Can I find deals for flights from Panama City to Rome that include hotel bookings?

    Yes. In addition to deals on Panama City to Rome flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Rome?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Rome.

  • Can I find deals for business class flights from Panama City to Rome?

    Yes. Cheapflights offers flight deals from Panama City to Rome by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Rome?

    Currently, August is the cheapest month in which you can book a flight from Panama City to Rome (average of $453). Flying from Panama City to Rome in January is currently the most expensive (average of $774). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Rome?

Book flights to Rome if you plan to visit one of these locations
Fiumicino
Montepulciano
Santa Marinella

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Alternative routes for Panama City to Rome

See prices for flight routes from nearby airports that may be better suited for you.
Panama City to Leonardo da Vinci/Fiumicino flights

Top 3 airlines flying from Panama City to Rome

Discover the top 3 airlines that operate flights from Panama City to Rome. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 10, 2026.
AirlineCheapestAverageFlexibilityOn-time
Air EuropaCheapest$679Average$952FlexibilityNo cancel feeOn-time83%
Turkish AirlinesCheapest$690Average$752FlexibilityNo cancel feeOn-time77%
Air FranceCheapest$818Average$972FlexibilityNo cancel feeOn-time77%

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