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$389+ Cheap flights from Panama City (PTY) to Rome (ROM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/10. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — ROM
Dec 4 — Dec 111
Thu 12/4
Thu 12/11
1 adult, Economy
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1. Tell us where you want to go

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Cheapflights Tip: The best prices from Panama City Tocumen Intl to Rome are usually found in March or May, booked 31 days in advance, depart on a Wednesday or Friday and return on a Monday

Cheap flight deals from Panama City to Rome

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Rome (ROM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 4, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$699
(Turkish Airlines)

One-way from

$389
(Kiwi.com)

Popular in

January

Cheapest in

March

Average price

$829
Provider with most accurate pricing for Panama City Tocumen Intl-Rome (ROM) flight deals.
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Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Rome (ROM) flights.
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From Panama City Tocumen Intl to Rome (ROM)
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One-way flight from Panama City Tocumen Intl to Rome (ROM)
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Highest demand for flights based on searches. 6% potential increase in price ($62 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($12 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Find flight deals from Panama City to Rome

Cheapest flights from Panama City to Rome
Explore the most affordable flight options available from Panama City to Rome. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 4, 2025.

This Turkish Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Turkish Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/229:45 pmPTY - FCO
1 stop38h 50mTurkish Airlines
Fri 12/57:45 pmFCO - PTY
1 stop30h 05mTurkish Airlines
Deal found 11/3$768
This Air France deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/273:22 pmPTY - FCO
1 stop34h 33mMultiple Airlines
Fri 1/235:15 pmFCO - PTY
1 stop32h 40mMultiple Airlines
Deal found 11/2$841
This KLM deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/256:45 pmPTY - FCO
1 stop22h 25mMultiple Airlines
Mon 1/126:25 pmFCO - PTY
1 stop31h 45mMultiple Airlines
Deal found 11/2$888
This Turkish Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Turkish Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/229:45 pmPTY - FCO
1 stop18h 10mTurkish Airlines
Wed 12/106:45 amFCO - PTY
1 stop19h 05mTurkish Airlines
Deal found 11/3$905
This SmartFares deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/279:45 pmPTY - FCO
1 stop34h 05mTurkish Airlines
Fri 1/236:45 amFCO - PTY
2 stops40h 20mTurkish Airlines
Deal found 11/2$910
This United Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/410:00 amPTY - FCO
1 stop15h 55mUnited Airlines
Thu 12/1110:30 amFCO - PTY
2 stops34h 15mUnited Airlines
Deal found 11/4$918
This KLM deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/66:45 pmPTY - FCO
1 stop22h 25mMultiple Airlines
Sat 11/224:20 pmFCO - PTY
1 stop33h 50mMultiple Airlines
Deal found 11/3$936
This Turkish Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Turkish Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/256:45 pmPTY - FCO
1 stop33h 05mTurkish Airlines
Fri 12/57:45 pmFCO - PTY
1 stop30h 05mTurkish Airlines
Deal found 11/3$954
This Mytrip deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/257:05 pmPTY - FCO
2 stops31h 10mMultiple Airlines
Sat 1/36:45 amFCO - PTY
1 stop19h 05mMultiple Airlines
Deal found 11/2$962

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Rome that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 4, 2025.
Use the filters below to find and compare flights from Panama City to Rome that are best for you.

Fly from

Panama City

Fly to

Rome

Route

Depart

Return

Price

Panama CityRome

PTY - FCO

PTYFCO

Panama City Tocumen Intl

Mon 3/16

9:45 pm-9:55 pm

1 stop18h 10m

Rome Fiumicino

Mon 3/30

7:05 am-8:20 pm

1 stop20h 15m

$699

Panama CityRome

PTY - FCO

PTYFCO

Panama City Tocumen Intl

Mon 3/30

10:15 pm-9:20 am

1 stop28h 05m

Rome Fiumicino

Wed 4/8

10:45 am-6:30 pm

2 stops38h 45m

$746

Panama CityRome

PTY - FCO

PTYFCO

Panama City Tocumen Intl

Sat 2/7

10:05 pm-7:25 pm

1 stop15h 20m

Rome Fiumicino

Mon 2/23

8:25 pm-4:30 pm

1 stop26h 05m

$838

Panama CityRome

PTY - FCO

PTYFCO

Panama City Tocumen Intl

Tue 3/31

8:10 pm-11:35 pm

1 stop20h 25m

Rome Fiumicino

Sat 5/2

10:45 am-6:30 pm

2 stops38h 45m

$878

Panama CityRome

PTY - FCO

PTYFCO

Panama City Tocumen Intl

Thu 12/25

6:45 pm-11:10 pm

1 stop22h 25m

Rome Fiumicino

Mon 1/12

6:25 pm-8:10 pm

1 stop31h 45m

$888

Panama CityRome

PTY - FCO

PTYFCO

Panama City Tocumen Intl

Wed 4/29

1:55 pm-11:05 pm

2 stops26h 10m

Rome Fiumicino

Fri 5/8

7:35 am-8:00 pm

1 stop19h 25m

$899

Panama CityRome

PTY - FCO

PTYFCO

Panama City Tocumen Intl

Mon 3/23

9:45 pm-1:50 pm

1 stop34h 05m

Rome Fiumicino

Tue 3/31

7:05 am-6:30 pm

2 stops42h 25m

$907

Panama CityRome

PTY - FCO

PTYFCO

Panama City Tocumen Intl

Sun 3/15

9:30 pm-5:25 pm

1 stop13h 55m

Rome Fiumicino

Thu 3/19

10:30 am-7:45 pm

1 stop15h 15m

$909

Panama CityRome

PTY - FCO

PTYFCO

Panama City Tocumen Intl

Sat 12/27

9:45 pm-1:50 pm

1 stop34h 05m

Rome Fiumicino

Fri 1/23

6:45 am-5:05 pm

2 stops40h 20m

$910

Panama CityRome

PTY - FCO

PTYFCO

Panama City Tocumen Intl

Mon 11/10

7:05 pm-9:50 am

2 stops32h 45m

$389

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/2

Showing 1-10 of 18 results
1
2

Compare providers for flights from Panama City to Rome

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Rome in November.
ProviderPrice AccuracyTrust Score*
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City-Rome flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Panama City-Rome flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Panama City-Rome flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City-Rome flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Rome flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Rome

Have a flexible travel schedule? Discover the best time to fly to Rome from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Rome

How far ahead should I book a flight from Panama City to Rome?

Use this chart to determine the optimal time to book a round-trip flight from Panama City to Rome. Price data was last updated on October 31, 2025.

The price you pay for your flight from Panama City to Rome may vary depending on when you book. For the best chance of a lower fare, look to book 31 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Panama City to Rome?

Currently, August is the cheapest month in which you can book a flight from Panama City to Rome (average of $454). Flying from Panama City to Rome in March is currently the most expensive (average of $762). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to ROM?

Find hourly flight availability from Panama City to Rome. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 4, 2025.

One of the essential ways to save on airfare from Panama City to Rome is to remain as flexible as possible. Flights that are in the afternoon tend to be the most expensive. A flight in the evening could potentially save you up to 4% on airfare.

How much does it cost to fly round-trip from Panama City to Rome?

What’s the top layover airport for flights from Panama City to Rome?

Share of 1-stop round-trip flights from Panama City to Rome chosen by Cheapflights users in the past 12 months, using the same layover each way.

Amsterdam (AMS) – chosen by Cheapflights users on 63% of 1-stop itineraries from Panama City to Rome on Cheapflights.

What’s the cheapest layover airport for flights from Panama City to Rome?

Average round-trip fare for 1-stop flights from Panama City to Rome, chosen by Cheapflights users in the past 12 months, with the same layover each way.

Amsterdam (AMS) is the most affordable 1-stop option, with an average round-trip price of $1,415.

What’s the fastest layover option from Panama City to Rome?

Shortest average travel time for 1-stop one-way flights from Panama City to Rome, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.

Flights via Madrid (MAD) have the shortest average one-way travel time for 1-stop routes: 14h 50m.

Which airport typically offers the quickest layover for flights from Panama City to Rome?

Average layover duration for 1-stop one-way flights from Panama City to Rome, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.

Flights via Madrid (MAD) offer the fastest connection on this route, with an average layover time of 2h 13m.

Reviews of airlines servicing Rome

Get insights into the airlines that provide service to Rome. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Rome. Reviews last updated November 4, 2025.
Read reviews from past customers who have flown KLM, Air France, and United Airlines from Panama City to Rome. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
KLM
7.7
Good
1,405 reviews

Boarding

7.8

Overall

7.7

Comfort

7.7

Entertainment

7.1

Crew

8.4

Food

7.3

Reviews

1 / 20
2.0
Mediocre

Abisola,Oct 2025

LOS - CDG

The food option was finished and what wa left was vegan pasta so I had to go without food for an 8 hour flight without any sort of empathy from crew that was mean.
KLM
7.7
Good
1,405 reviews
KLM
7.7
Good
1,405 reviews

Boarding

7.8

Overall

7.7

Comfort

7.7

Entertainment

7.1

Crew

8.4

Food

7.3

Reviews

1 / 20
2.0
Mediocre

Abisola,Oct 2025

LOS - CDG

The food option was finished and what wa left was vegan pasta so I had to go without food for an 8 hour flight without any sort of empathy from crew that was mean.
Air France
7.4
Good
1,482 reviews
KLM
7.7
Good
1,405 reviews

Boarding

7.8

Overall

7.7

Comfort

7.7

Entertainment

7.1

Crew

8.4

Food

7.3

Reviews

1 / 20
2.0
Mediocre

Abisola,Oct 2025

LOS - CDG

The food option was finished and what wa left was vegan pasta so I had to go without food for an 8 hour flight without any sort of empathy from crew that was mean.
United Airlines
7.4
Good
8,998 reviews
KLM
7.7
Good
1,405 reviews

Boarding

7.8

Overall

7.7

Comfort

7.7

Entertainment

7.1

Crew

8.4

Food

7.3

Reviews

1 / 20
2.0
Mediocre

Abisola,Oct 2025

LOS - CDG

The food option was finished and what wa left was vegan pasta so I had to go without food for an 8 hour flight without any sort of empathy from crew that was mean.
Turkish Airlines
7.3
Good
4,038 reviews
KLM
7.7
Good
1,405 reviews

Boarding

7.8

Overall

7.7

Comfort

7.7

Entertainment

7.1

Crew

8.4

Food

7.3

Reviews

1 / 20
2.0
Mediocre

Abisola,Oct 2025

LOS - CDG

The food option was finished and what wa left was vegan pasta so I had to go without food for an 8 hour flight without any sort of empathy from crew that was mean.
Air Europa
7.0
Good
568 reviews
KLM
7.7
Good
1,405 reviews

Boarding

7.8

Overall

7.7

Comfort

7.7

Entertainment

7.1

Crew

8.4

Food

7.3

Reviews

1 / 20
2.0
Mediocre

Abisola,Oct 2025

LOS - CDG

The food option was finished and what wa left was vegan pasta so I had to go without food for an 8 hour flight without any sort of empathy from crew that was mean.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Rome. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to Rome?

    Located just 11.4 mi from the city center, Panama City Tocumen Intl is the airport most travelers will use when flying to Rome from Panama City. Booking flights from Tocumen Intl (PTY) to Rome should be relatively easy as there are 0 daily outbound flights to Rome from 4 different airlines.

  • How long is the flight from Panama City to Rome?

    Airlines like Turkish Airlines and KLM fly from Panama City to Rome in about 15h 20m. The time it takes to get you to your destination can typically vary by up to 2h 50m. Panama City and Rome are separated by a distance of 5881 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Panama City to Rome round-trip?

    Flying on Air Europa is currently your cheapest option to Rome, with prices starting at $679. Additional round-trip tickets that might be worth considering are offered by Turkish Airlines and Iberia, with the lowest prices starting at $690 and $767, respectively. You may be able to fly from Panama City to Rome for 22% less than the average price by searching for these airlines.

  • Can I find deals for flights from Panama City to Rome that include hotel bookings?

    Yes. In addition to deals on Panama City to Rome flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Rome?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Rome.

  • Can I find deals for business class flights from Panama City to Rome?

    Yes. Cheapflights offers flight deals from Panama City to Rome by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Rome?

    Currently, August is the cheapest month in which you can book a flight from Panama City to Rome (average of $454). Flying from Panama City to Rome in March is currently the most expensive (average of $762). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Rome?

Book flights to Rome if you plan to visit one of these locations
Fiumicino
Montepulciano
Santa Marinella

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Alternative routes for Panama City to Rome

See prices for flight routes from nearby airports that may be better suited for you.
Panama City to Leonardo da Vinci/Fiumicino flights

Top 4 airlines flying from Panama City to Rome

Discover the top 4 airlines that operate flights from Panama City to Rome. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 4, 2025.
AirlineCheapestAverageFlexibilityOn-time
Air EuropaCheapest$679Average$945FlexibilityNo cancel feeOn-time83%
Turkish AirlinesCheapest$690Average$788FlexibilityNo cancel feeOn-time77%
IberiaCheapest$767Average$778FlexibilityNo cancel feeOn-time77%
Air FranceCheapest$818Average$972FlexibilityNo cancel feeOn-time77%

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