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$292+ Cheap flights from Missouri to Rome (ROM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/18. Fares are subject to change and may not be available on all flights or dates of travel.
STL — ROM
Dec 20 — Dec 271
Sat 12/20
Sat 12/27
1 adult, Economy
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Cheap flight deals from Missouri to Rome

Keep the following information in mind while searching for Missouri to Rome flight deals. Data was last updated November 20, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$437
(Kiwi.com)

One-way from

$292
(Kiwi.com)

Popular in

June

Cheapest in

November

Average price

$709
Provider with most accurate pricing for Lambert-St Louis-Rome (ROM) flight deals.
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Provider most trusted by Cheapflights users for Lambert-St Louis-Rome (ROM) flights.
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From Missouri to Rome (ROM)
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One-way flight from Missouri to Rome (ROM)
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Highest demand for flights based on searches. 26% potential increase in price ($353 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($55 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Find flight deals from Missouri to Rome

Cheapest flights from Missouri to Rome
Explore the most affordable flight options available from Missouri to Rome. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 20, 2025.

This United Airlines deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/305:02 pmSTL - FCO
2 stops36h 38mUnited Airlines
Wed 1/1411:15 amFCO - STL
2 stops34h 15mUnited Airlines
Deal found 11/20$502
This KLM deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/307:00 amSTL - FCO
1 stop20h 30mKLM
Wed 1/1412:45 pmFCO - STL
2 stops17h 54mKLM
Deal found 11/18$507
This Delta deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/306:00 amSTL - FCO
2 stops18h 55mDelta
Wed 1/1412:45 pmFCO - STL
2 stops17h 54mDelta
Deal found 11/18$511
This Kiwi.com deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/711:36 amMCI - FCO
1 stop13h 09mLufthansa
Sun 12/1412:20 pmFCO - MCI
2 stops16h 38mLufthansa
Deal found 11/20$637
This FlightHub deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/412:55 pmSTL - FCO
1 stop12h 35mMultiple Airlines
Tue 12/91:10 pmFCO - STL
1 stop33h 19mMultiple Airlines
Deal found 11/20$668
This United Airlines deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/711:36 amMCI - FCO
1 stop13h 09mUnited Airlines
Sun 12/141:10 pmFCO - MCI
3 stops37h 17mUnited Airlines
Deal found 11/20$683
This United Airlines deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/103:05 pmCOU - FCO
1 stop33h 40mUnited Airlines
Sun 12/141:10 pmFCO - COU
2 stops56h 16mUnited Airlines
Deal found 11/18$684
This Cheapflightsfares deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/412:55 pmSTL - FCO
1 stop12h 35mLufthansa
Tue 12/911:00 amFCO - STL
1 stop15h 13mLufthansa
Deal found 11/19$688
This United Airlines deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/512:55 pmSTL - FCO
1 stop12h 35mUnited Airlines
Sat 12/1310:55 amFCO - STL
2 stops35h 45mUnited Airlines
Deal found 11/18$690
This Air Canada deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/41:00 pmSTL - FCO
2 stops37h 25mAir Canada
Tue 12/91:10 pmFCO - STL
2 stops32h 15mAir Canada
Deal found 11/19$695
This Delta deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/85:50 amMCI - FCO
1 stop21h 40mDelta
Mon 12/156:10 amFCO - MCI
2 stops21h 58mDelta
Deal found 11/20$707
This Finnair deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Finnair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/86:44 amMCI - FCO
2 stops19h 16mMultiple Airlines
Mon 12/1511:00 amFCO - MCI
2 stops19h 45mMultiple Airlines
Deal found 11/20$711

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Rome that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 20, 2025.
Use the filters below to find and compare flights from Missouri to Rome that are best for you.

Fly from

Missouri

Fly to

Rome

Route

Depart

Return

Price

St. LouisRome

STL - FCO

STLFCO

Lambert-St Louis

Wed 1/14

9:57 am-1:25 pm

2 stops20h 28m

Rome Fiumicino

Wed 1/21

11:15 am-7:27 pm

2 stops39h 12m

$491

St. LouisRome

STL - FCO

STLFCO

Lambert-St Louis

Tue 1/20

11:22 am-7:55 am

1 stop13h 33m

Rome Fiumicino

Wed 1/28

7:05 am-1:55 pm

1 stop13h 50m

$493

SpringfieldRome

SGF - FCO

SGFFCO

Springfield-Branson

Thu 1/1

6:00 am-7:55 am

2 stops18h 55m

Rome Fiumicino

Sat 1/17

12:40 pm-12:11 pm

1 stop30h 31m

$497

St. LouisRome

STL - FCO

STLFCO

Lambert-St Louis

Wed 1/21

9:57 am-7:55 am

2 stops14h 58m

Rome Fiumicino

Wed 1/28

7:05 am-1:55 pm

1 stop13h 50m

$498

SpringfieldRome

SGF - FCO

SGFFCO

Springfield-Branson

Fri 1/23

7:45 am-9:25 am

2 stops18h 40m

Rome Fiumicino

Tue 1/27

7:05 am-12:46 pm

2 stops36h 41m

$502

St. LouisRome

STL - FCO

STLFCO

Lambert-St Louis

Tue 2/3

11:22 am-7:55 am

1 stop13h 33m

Rome Fiumicino

Fri 2/13

9:45 am-9:00 pm

2 stops18h 15m

$503

St. LouisRome

STL - FCO

STLFCO

Lambert-St Louis

Tue 1/20

12:44 pm-8:30 am

1 stop12h 46m

Rome Fiumicino

Tue 1/27

7:05 am-4:03 pm

2 stops15h 58m

$503

St. LouisRome

STL - FCO

STLFCO

Lambert-St Louis

Wed 1/21

11:22 am-7:55 am

1 stop13h 33m

Rome Fiumicino

Tue 1/27

7:05 am-7:27 pm

2 stops19h 22m

$503

St. LouisRome

STL - FCO

STLFCO

Lambert-St Louis

Wed 1/28

11:22 am-7:55 am

1 stop13h 33m

Rome Fiumicino

Sun 2/1

12:45 pm-3:29 pm

1 stop33h 44m

$503

St. LouisRome

STL - FCO

STLFCO

Lambert-St Louis

Mon 1/19

4:05 pm-10:55 am

1 stop11h 50m

Rome Fiumicino

Tue 1/27

7:05 am-5:43 pm

2 stops17h 38m

$505

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/19

Showing 1-10 of 60 results
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Best time to book a flight from Missouri to Rome

Have a flexible travel schedule? Discover the best time to fly to Rome from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Rome

What is the cheapest month to book a flight from Missouri to Rome?

Currently, January is the cheapest month in which you can book a flight from Missouri to Rome (average of $541). Flying from Missouri to Rome in July is currently the most expensive (average of $999). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to ROM?

Find hourly flight availability from Missouri to Rome. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 20, 2025.

One of the essential ways to save on airfare from Missouri to Rome is to remain as flexible as possible. Flights that are in the afternoon tend to be the most expensive. A flight in the evening could potentially save you up to 31% on airfare.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Rome. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Missouri to Rome?

    A quick flight from Missouri to Rome can take about 13h 33m. United Airlines provides one of the quickest options available for as low as $493. There are 5050 mi between Missouri and Rome. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Missouri to Rome one-way?

    The cheapest airline one-way is Scandinavian Airlines, with whom users have recently found tickets for as low as $365. However, be on the lookout for offers from Brussels Airlines and United Airlines, as they are both options that can get you from Missouri to Rome for a low price.

  • What are the most popular routes from Missouri to Rome?

    While some choose either Lambert-St Louis - Rome Fiumicino or Springfield-Branson - Rome Fiumicino, Kansas City - Rome Fiumicino is the most popular route from Missouri to Rome.

  • Can I find deals for flights from Missouri to Rome that include hotel bookings?

    Yes. In addition to deals on Missouri to Rome flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Rome?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Rome.

  • Can I find deals for business class flights from Missouri to Rome?

    Yes. Cheapflights offers flight deals from Missouri to Rome by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Rome?

    Currently, January is the cheapest month in which you can book a flight from Missouri to Rome (average of $541). Flying from Missouri to Rome in July is currently the most expensive (average of $999). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Rome?

Book flights to Rome if you plan to visit one of these locations
Fiumicino
Montepulciano
Santa Marinella

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Alternative routes for Missouri to Rome

See prices for flight routes from nearby airports that may be better suited for you.
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Top 9 airlines flying from Missouri to Rome

Discover the top 9 airlines that operate flights from Missouri to Rome. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 20, 2025.
AirlineCheapestAverageFlexibilityOn-time
IberiaCheapest$536Average$1,226FlexibilityNo cancel feeOn-time77%
United AirlinesCheapest$549Average$1,095FlexibilityNo cancel feeOn-time69%
DeltaCheapest$554Average$856FlexibilityNo cancel feeOn-timeN/A
KLMCheapest$566Average$1,004FlexibilityNo cancel feeOn-time75%
Air FranceCheapest$655Average$1,282FlexibilityNo cancel feeOn-time77%
American AirlinesCheapest$665Average$1,185FlexibilityNo cancel feeOn-time71%
LufthansaCheapest$671Average$1,094FlexibilityNo cancel feeOn-time76%
Air CanadaCheapest$705Average$1,157FlexibilityNo cancel feeOn-time67%
British AirwaysCheapest$711Average$1,146FlexibilityNo cancel feeOn-time70%

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