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$281+ Cheap flights from Missouri to Rome (ROM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/18. Fares are subject to change and may not be available on all flights or dates of travel.
STL — ROM
Dec 5 — Dec 121
Fri 12/5
Fri 12/12
1 adult, Economy
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Cheap flight deals from Missouri to Rome

Keep the following information in mind while searching for Missouri to Rome flight deals. Data was last updated November 5, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$435
(Kiwi.com)

One-way from

$281
(Kiwi.com)

Popular in

June

Cheapest in

February

Average price

$729
Provider with most accurate pricing for Lambert-St Louis-Rome (ROM) flight deals.
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Provider most trusted by Cheapflights users for Lambert-St Louis-Rome (ROM) flights.
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From Missouri to Rome (ROM)
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One-way flight from Missouri to Rome (ROM)
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Highest demand for flights based on searches. 25% potential increase in price ($357 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($52 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Find flight deals from Missouri to Rome

Cheapest flights from Missouri to Rome
Explore the most affordable flight options available from Missouri to Rome. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 5, 2025.

This Kiwi.com deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/86:42 pmSTL - FCO
2 stops21h 18mLufthansa
Wed 12/247:05 amFCO - STL
1 stop13h 50mLufthansa
Deal found 11/4$435
This United Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/211:36 amMCI - FCO
1 stop13h 09mUnited Airlines
Fri 12/121:10 pmFCO - MCI
2 stops37h 28mUnited Airlines
Deal found 11/4$483
This Orbitz deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/304:05 pmSTL - FCO
2 stops34h 15mAir Canada
Wed 1/1411:15 amFCO - STL
2 stops34h 15mAir Canada
Deal found 11/4$485
This United Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/812:55 pmSTL - FCO
1 stop12h 35mUnited Airlines
Wed 12/247:05 amFCO - STL
1 stop13h 50mUnited Airlines
Deal found 11/4$487
This United Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/306:35 pmSTL - FCO
2 stops30h 20mUnited Airlines
Wed 1/1411:15 amFCO - STL
2 stops34h 15mUnited Airlines
Deal found 11/4$488
This United Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/48:30 amSTL - FCO
1 stop17h 00mUnited Airlines
Tue 12/91:10 pmFCO - STL
2 stops30h 05mUnited Airlines
Deal found 11/4$489
This United Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/411:36 amMCI - FCO
2 stops38h 49mUnited Airlines
Thu 12/1110:55 amFCO - MCI
2 stops39h 32mUnited Airlines
Deal found 11/4$489
This United Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/58:00 amCOU - FCO
1 stop16h 45mUnited Airlines
Tue 12/91:10 pmFCO - COU
2 stops35h 30mUnited Airlines
Deal found 11/4$489
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/26:27 pmMCI - FCO
1 stop30h 18mUnited Airlines
Mon 12/810:55 amFCO - MCI
2 stops42h 03mUnited Airlines
Deal found 11/3$490
This United deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/86:30 amSTL - FCO
2 stops18h 25mMultiple Airlines
Wed 12/241:30 pmFCO - STL
2 stops33h 57mMultiple Airlines
Deal found 11/4$493
This Priceline deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/26:27 pmMCI - FCO
2 stops31h 58mAir Canada
Mon 12/810:55 amFCO - MCI
2 stops37h 30mAir Canada
Deal found 11/3$495
This Booking.com deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/26:27 pmMCI - FCO
2 stops31h 58mAir Canada
Sun 12/71:10 pmFCO - MCI
2 stops37h 17mAir Canada
Deal found 11/4$497

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Rome that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 5, 2025.
Use the filters below to find and compare flights from Missouri to Rome that are best for you.

Fly from

Missouri

Fly to

Rome

Route

Depart

Return

Price

Kansas CityRome

MCI - FCO

MCIFCO

Kansas City

Tue 12/2

6:27 pm-7:45 am

1 stop30h 18m

Rome Fiumicino

Fri 12/12

1:10 pm-5:29 pm

2 stops35h 19m

$483

Kansas CityRome

MCI - FCO

MCIFCO

Kansas City

Tue 12/2

6:27 pm-9:25 am

3 stops31h 58m

Rome Fiumicino

Fri 12/12

1:10 pm-7:38 pm

2 stops37h 28m

$483

St. LouisRome

STL - FCO

STLFCO

Lambert-St Louis

Thu 12/4

8:30 am-8:30 am

1 stop17h 00m

Rome Fiumicino

Tue 12/9

1:10 pm-12:15 pm

2 stops30h 05m

$489

Kansas CityRome

MCI - FCO

MCIFCO

Kansas City

Thu 12/4

11:36 am-9:25 am

2 stops38h 49m

Rome Fiumicino

Thu 12/11

10:55 am-7:27 pm

2 stops39h 32m

$489

ColumbiaRome

COU - FCO

COUFCO

Columbia Regional

Fri 12/5

8:00 am-7:45 am

1 stop16h 45m

Rome Fiumicino

Tue 12/9

1:10 pm-5:40 pm

2 stops35h 30m

$489

Kansas CityRome

MCI - FCO

MCIFCO

Kansas City

Thu 1/8

12:35 pm-6:15 pm

2 stops22h 40m

Rome Fiumicino

Tue 1/13

1:10 pm-3:10 pm

2 stops33h 00m

$497

Kansas CityRome

MCI - FCO

MCIFCO

Kansas City

Wed 1/7

6:30 pm-6:15 pm

2 stops16h 45m

Rome Fiumicino

Tue 1/13

1:10 pm-4:08 pm

2 stops33h 58m

$497

St. LouisRome

STL - FCO

STLFCO

Lambert-St Louis

Sun 2/1

6:30 am-9:25 am

2 stops19h 55m

Rome Fiumicino

Tue 2/10

7:05 am-3:29 pm

2 stops39h 24m

$499

Kansas CityRome

MCI - FCO

MCIFCO

Kansas City

Thu 12/4

10:00 am-8:30 am

2 stops15h 30m

Rome Fiumicino

Thu 12/11

9:40 am-7:27 pm

2 stops16h 47m

$502

Kansas CityRome

MCI - FCO

MCIFCO

Kansas City

Tue 12/2

6:27 pm-9:25 am

3 stops31h 58m

Rome Fiumicino

Tue 12/9

7:05 am-11:44 pm

2 stops23h 39m

$502

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/2

Showing 1-10 of 48 results
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Best time to book a flight from Missouri to Rome

Have a flexible travel schedule? Discover the best time to fly to Rome from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Rome

What is the cheapest month to book a flight from Missouri to Rome?

Currently, June is the cheapest month in which you can book a flight from Missouri to Rome (average of $450). Flying from Missouri to Rome in July is currently the most expensive (average of $999). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to ROM?

Find hourly flight availability from Missouri to Rome. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 5, 2025.

One of the essential ways to save on airfare from Missouri to Rome is to remain as flexible as possible. Flights that are in the afternoon tend to be the most expensive. A flight in the evening could potentially save you up to 31% on airfare.

How much does it cost to fly round-trip from Missouri to Rome?

Related info for your journey

Find useful and relevant information for your journey from Missouri to Rome. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Missouri to Rome?

    A quick flight from Missouri to Rome can take about 14h 51m. United Airlines provides one of the quickest options available for as low as $506. There are 5050 mi between Missouri and Rome. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Missouri to Rome one-way?

    The cheapest airline one-way is Scandinavian Airlines, with whom users have recently found tickets for as low as $365. However, be on the lookout for offers from Air Canada and Lufthansa, as they are both options that can get you from Missouri to Rome for a low price.

  • What are the most popular routes from Missouri to Rome?

    While some choose either Lambert-St Louis - Rome Fiumicino or Springfield-Branson - Rome Fiumicino, Kansas City - Rome Fiumicino is the most popular route from Missouri to Rome.

  • Can I find deals for flights from Missouri to Rome that include hotel bookings?

    Yes. In addition to deals on Missouri to Rome flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Rome?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Rome.

  • Can I find deals for business class flights from Missouri to Rome?

    Yes. Cheapflights offers flight deals from Missouri to Rome by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Rome?

    Currently, June is the cheapest month in which you can book a flight from Missouri to Rome (average of $450). Flying from Missouri to Rome in July is currently the most expensive (average of $999). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Rome?

Book flights to Rome if you plan to visit one of these locations
Fiumicino
Montepulciano
Santa Marinella

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Alternative routes for Missouri to Rome

See prices for flight routes from nearby airports that may be better suited for you.
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Top 9 airlines flying from Missouri to Rome

Discover the top 9 airlines that operate flights from Missouri to Rome. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 5, 2025.
AirlineCheapestAverageFlexibilityOn-time
IberiaCheapest$536Average$1,226FlexibilityNo cancel feeOn-time77%
United AirlinesCheapest$549Average$1,095FlexibilityNo cancel feeOn-time69%
DeltaCheapest$554Average$856FlexibilityNo cancel feeOn-timeN/A
KLMCheapest$566Average$1,004FlexibilityNo cancel feeOn-time75%
Air FranceCheapest$655Average$1,282FlexibilityNo cancel feeOn-time77%
American AirlinesCheapest$665Average$1,185FlexibilityNo cancel feeOn-time71%
LufthansaCheapest$671Average$1,094FlexibilityNo cancel feeOn-time76%
Air CanadaCheapest$705Average$1,157FlexibilityNo cancel feeOn-time67%
British AirwaysCheapest$711Average$1,146FlexibilityNo cancel feeOn-time70%

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