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$253+ Cheap flights from Syracuse (SYR) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/14. Fares are subject to change and may not be available on all flights or dates of travel.
SYR — PTY
Mar 27 — Apr 31
Fri 3/27
Fri 4/3
1 adult, Economy
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Cheap flight deals from Syracuse to Panama

Cheapest flights from Syracuse to Panama
Explore the most affordable flight options available from Syracuse to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 25, 2026.

This American Airlines deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/281:19 pm
SYR
-
PTY
2 stops23h 51m
American Airlines
Sat 8/83:20 pm
PTY
-
SYR
2 stops18h 59m
American Airlines
Deal found 2/24$573
This BusinessClass deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/142:55 pm
SYR
-
PTY
1 stop14h 09m
Copa Airlines
Sat 4/183:30 pm
PTY
-
SYR
2 stops17h 25m
Copa Airlines
Deal found 2/21$575
This BusinessClass deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/146:15 am
SYR
-
PTY
1 stop14h 16m
Multiple Airlines
Sat 4/1810:55 pm
PTY
-
SYR
1 stop20h 25m
Multiple Airlines
Deal found 2/21$577
This American Airlines deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/77:36 pm
SYR
-
PTY
2 stops18h 10m
American Airlines
Thu 4/91:49 pm
PTY
-
SYR
2 stops20h 44m
American Airlines
Deal found 2/23$619
This Delta deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/56:09 am
SYR
-
PTY
1 stop7h 41m
Delta
Thu 3/122:28 pm
PTY
-
SYR
1 stop8h 31m
Delta
Deal found 2/23$646
This United Airlines deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/56:25 am
SYR
-
PTY
2 stops13h 37m
United Airlines
Thu 3/1211:35 am
PTY
-
SYR
2 stops21h 07m
United Airlines
Deal found 2/23$650
This KAYAK deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/72:55 pm
SYR
-
PTY
1 stop14h 09m
Multiple Airlines
Thu 4/99:45 am
PTY
-
SYR
1 stop9h 35m
Multiple Airlines
Deal found 2/23$717
This KAYAK deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/72:45 pm
SYR
-
PTY
2 stops14h 19m
Copa Airlines
Thu 4/99:45 am
PTY
-
SYR
1 stop9h 35m
Copa Airlines
Deal found 2/23$721
This United Airlines deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/297:40 pm
SYR
-
PTY
2 stops23h 57m
United Airlines
Thu 4/29:45 am
PTY
-
SYR
1 stop9h 35m
United Airlines
Deal found 2/22$727
This Ovago deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/145:00 pm
SYR
-
PTY
2 stops21h 13m
LATAM Airlines
Thu 8/202:28 pm
PTY
-
SYR
1 stop19h 44m
LATAM Airlines
Deal found 2/22$732
This United Airlines deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/252:43 pm
SYR
-
PTY
2 stops24h 02m
United Airlines
Sun 4/53:30 pm
PTY
-
SYR
2 stops28h 17m
United Airlines
Deal found 2/24$745

Find flight deals from Syracuse to Panama

Keep the following information in mind while searching for Syracuse to Panama flight deals. Data was last updated February 25, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$573
(United Airlines)

One-way from

$253
(United Airlines)

Popular in

February

Cheapest in

October

Average price

$948
Provider with most accurate pricing for Syracuse Hancock Intl-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Syracuse Hancock Intl-Panama City Tocumen Intl flights.
Search Deals
From Syracuse Hancock Intl to Panama
Search Deals
One-way flight from Syracuse Hancock Intl to Panama
Search Deals
Highest demand for flights based on searches. 16% potential increase in price ($119 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($37 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Syracuse to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 25, 2026.
Use the filters below to find and compare flights from Syracuse to Panama that are best for you.

Fly from

Syracuse

Fly to

Panama

Route

Depart

Return

Price

SyracusePanama City

SYR - PTY

SYRPTY

Syracuse Hancock Intl

Tue 4/14

5:42 pm-2:14 pm

2 stops21h 32m

Panama City Tocumen Intl

Sat 4/18

3:30 pm-9:55 am

2 stops17h 25m

$573

SyracusePanama City

SYR - PTY

SYRPTY

Syracuse Hancock Intl

Sun 3/29

6:11 pm-12:41 pm

2 stops19h 30m

Panama City Tocumen Intl

Thu 4/2

3:51 pm-2:59 pm

2 stops22h 08m

$573

SyracusePanama City

SYR - PTY

SYRPTY

Syracuse Hancock Intl

Thu 6/18

5:44 pm-4:12 pm

2 stops23h 28m

Panama City Tocumen Intl

Fri 6/26

3:30 pm-4:48 pm

2 stops24h 18m

$573

SyracusePanama City

SYR - PTY

SYRPTY

Syracuse Hancock Intl

Fri 4/10

7:40 pm-2:14 pm

2 stops19h 34m

Panama City Tocumen Intl

Fri 4/17

9:45 am-11:50 pm

2 stops13h 05m

$573

SyracusePanama City

SYR - PTY

SYRPTY

Syracuse Hancock Intl

Tue 4/14

6:15 am-7:31 pm

1 stop14h 16m

Panama City Tocumen Intl

Sat 4/18

10:55 pm-8:20 pm

1 stop20h 25m

$577

SyracusePanama City

SYR - PTY

SYRPTY

Syracuse Hancock Intl

Tue 4/7

7:36 pm-12:46 pm

2 stops18h 10m

Panama City Tocumen Intl

Thu 4/9

1:49 pm-11:33 am

2 stops20h 44m

$619

SyracusePanama City

SYR - PTY

SYRPTY

Syracuse Hancock Intl

Wed 3/25

2:43 pm-1:45 pm

2 stops24h 02m

Panama City Tocumen Intl

Sun 4/5

3:30 pm-8:47 pm

2 stops28h 17m

$745

SyracusePanama City

SYR - PTY

SYRPTY

Syracuse Hancock Intl

Fri 4/10

6:01 am-1:03 pm

1 stop8h 02m

Panama City Tocumen Intl

Fri 4/17

2:27 pm-12:03 am

1 stop8h 36m

$800

SyracusePanama City

SYR - PTY

SYRPTY

Syracuse Hancock Intl

Sat 8/22

6:30 am-6:37 pm

2 stops13h 07m

Panama City Tocumen Intl

Wed 8/26

3:20 pm-1:39 pm

2 stops21h 19m

$956

SyracusePanama City

SYR - PTY

SYRPTY

Syracuse Hancock Intl

Sat 3/14

6:25 am-4:10 am

2 stops22h 45m

$253

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/21

Showing 1-10 of 14 results
1
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Best time to book a flight from Syracuse to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Syracuse with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Syracuse to Panama

What is the cheapest month to book a flight from Syracuse to Panama?

Currently, March is the cheapest month in which you can book a flight from Syracuse to Panama (average of $261). Flying from Syracuse to Panama in December is currently the most expensive (average of $646). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated February 25, 2026.
Read reviews from past customers who have flown Delta and United Airlines from Syracuse to Panama. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,238 reviews

Overall

7.9

Entertainment

7.8

Boarding

8.1

Crew

8.5

Comfort

7.9

Food

7.2

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
Delta
7.9
Good
8,238 reviews
Delta
7.9
Good
8,238 reviews

Overall

7.9

Entertainment

7.8

Boarding

8.1

Crew

8.5

Comfort

7.9

Food

7.2

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
United Airlines
7.4
Good
9,345 reviews
Delta
7.9
Good
8,238 reviews

Overall

7.9

Entertainment

7.8

Boarding

8.1

Crew

8.5

Comfort

7.9

Food

7.2

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.

Related info for your journey

Find useful and relevant information for your journey from Syracuse to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Syracuse to Panama?

    If you book a flight to Panama from Syracuse, you will be flying from Hancock Intl, which is the city’s only airport. Syracuse Hancock Intl (SYR) is located 4.8 mi from the center of Syracuse.

  • How long is the flight from Syracuse to Panama?

    For as low as $573, United Airlines can have you in Panama from Syracuse in 21h 32m. Syracuse and Panama are separated by a distance of 2359 mi.

  • Can I find deals for flights from Syracuse to Panama that include hotel bookings?

    Yes. In addition to deals on Syracuse to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Syracuse to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Syracuse to Panama.

  • Can I find deals for business class flights from Syracuse to Panama?

    Yes. Cheapflights offers flight deals from Syracuse to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Syracuse to Panama?

    Currently, March is the cheapest month in which you can book a flight from Syracuse to Panama (average of $261). Flying from Syracuse to Panama in December is currently the most expensive (average of $646). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top 2 airlines flying from Syracuse to Panama

Discover the top 2 airlines that operate flights from Syracuse to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 25, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$308Average$623FlexibilityNo cancel feeOn-time69%
DeltaCheapest$491Average$551FlexibilityNo cancel feeOn-timeN/A

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