$734+ Cheap flights from Mississippi to Panama
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/1. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — PTY
Dec 9 — Dec 161
Round-trip
1 adult, Economy
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Find cheap flights from Mississippi to Panama with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Mississippi to Panama
Cheapest
Best
Last-minute
Cheapest flights from Mississippi to PanamaExplore the most affordable flight options available from Mississippi to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 9, 2026.
Explore the most affordable flight options available from Mississippi to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 9, 2026.
This United Airlines deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/711:58 am -
1 stop6h 40m
Mon 12/148:55 am -
1 stop8h 39m
Deal found 11/7![United Airlines logo]()
$775
This American Airlines deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/75:53 pm -
2 stops19h 20m
Mon 12/143:13 pm -
2 stops21h 26m
Deal found 11/7![American Airlines logo]()
$883
This Delta deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/246:00 am -
1 stop14h 45m
Thu 12/318:00 am -
1 stop15h 04m
Deal found 11/9![Delta logo]()
$1,026
This United Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/249:00 am -
1 stop9h 38m
Thu 12/318:55 am -
1 stop14h 04m
Deal found 11/8![United Airlines logo]()
$1,279
This American Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/2412:18 pm -
2 stops24h 23m
Thu 12/312:41 pm -
2 stops22h 05m
Deal found 11/9![American Airlines logo]()
$1,580
Best flights from Mississippi to PanamaDiscover carefully curated flight deals from Mississippi to Panama that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 9, 2026.
Discover carefully curated flight deals from Mississippi to Panama that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 9, 2026.
This United Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/17:00 am -
1 stop11h 37m
Wed 5/510:00 am -
1 stop9h 42m
Deal found 11/4![United Airlines logo]()
$734
This American Airlines deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/164:58 pm -
2 stops21h 57m
Mon 1/254:55 pm -
2 stops19h 44m
Deal found 11/7![American Airlines logo]()
$792
This Delta deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/246:00 am -
1 stop14h 45m
Thu 12/318:00 am -
1 stop15h 04m
Deal found 11/9![Delta logo]()
$1,026
This United Airlines deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/162:00 pm -
1 stop23h 45m
Mon 1/258:55 am -
1 stop27h 31m
Deal found 11/7![United Airlines logo]()
$814
This United Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/249:00 am -
1 stop9h 38m
Thu 12/318:55 am -
1 stop14h 04m
Deal found 11/8![United Airlines logo]()
$1,279
This BusinessClass deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/162:00 pm -
2 stops16h 49m
Mon 1/258:55 am -
1 stop8h 38m
Deal found 11/7![Copa Airlines logo]()
$3,389
This American Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/247:14 pm -
3 stops17h 27m
Thu 12/312:41 pm -
3 stops19h 16m
Deal found 11/9![American Airlines logo]()
$2,911
This United Airlines deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/711:58 am -
1 stop6h 40m
Mon 12/149:25 am -
2 stops13h 16m
Deal found 11/7![United Airlines logo]()
$5,097
This United Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/267:00 am -
2 stops13h 34m
Wed 4/288:28 am -
2 stops12h 50m
Deal found 11/4![United Airlines logo]()
$5,276
Last-minute flights from Mississippi to PanamaDiscover last-minute flight deals from Mississippi to Panama. Data last updated November 9, 2026 and is based on user searches.
Discover last-minute flight deals from Mississippi to Panama. Data last updated November 9, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/711:58 am -
1 stop6h 40m
Mon 12/148:55 am -
1 stop8h 39m
Deal found 11/7![United Airlines logo]()
$775
This American Airlines deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/75:53 pm -
2 stops19h 20m
Mon 12/143:13 pm -
2 stops21h 26m
Deal found 11/7![American Airlines logo]()
$883
This Delta deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/246:00 am -
1 stop14h 45m
Thu 12/318:00 am -
1 stop15h 04m
Deal found 11/9![Delta logo]()
$1,026
This United Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/249:00 am -
1 stop9h 38m
Thu 12/318:55 am -
1 stop14h 04m
Deal found 11/8![United Airlines logo]()
$1,279
This American Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/2412:18 pm -
2 stops24h 23m
Thu 12/312:41 pm -
2 stops22h 05m
Deal found 11/9![American Airlines logo]()
$1,580
Find flight deals from Mississippi to Panama
Keep the following information in mind while searching for Mississippi to Panama flight deals. Data was last updated November 9, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $681 (United Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Mississippi to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 9, 2026.
Use the filters below to find and compare flights from Mississippi to Panama that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
GulfportPanama City
GPT Gulfport Biloxi Regional - PTY Panama City Tocumen Intl
GPTPTY
Gulfport Biloxi Regional
Sat 5/1
7:00 am-6:37 pm
1 stop11h 37m
Panama City Tocumen Intl
Wed 5/5
10:00 am-7:42 pm
1 stop9h 42m
$734
JacksonPanama City
JAN Jackson-Evers Intl - PTY Panama City Tocumen Intl
JANPTY
Jackson-Evers Intl
Sat 1/16
4:58 pm-3:55 pm
2 stops21h 57m
Panama City Tocumen Intl
Mon 1/25
4:55 pm-11:39 am
2 stops19h 44m
$792
JacksonPanama City
JAN Jackson-Evers Intl - PTY Panama City Tocumen Intl
JANPTY
Jackson-Evers Intl
Sat 1/16
2:00 pm-2:45 pm
1 stop23h 45m
Panama City Tocumen Intl
Mon 1/25
8:55 am-11:26 am
1 stop27h 31m
$814
JacksonPanama City
JAN Jackson-Evers Intl - PTY Panama City Tocumen Intl
JANPTY
Jackson-Evers Intl
Thu 12/24
6:00 am-9:45 pm
1 stop14h 45m
Panama City Tocumen Intl
Thu 12/31
8:00 am-10:04 pm
1 stop15h 04m
$1,026
JacksonPanama City
JAN Jackson-Evers Intl - PTY Panama City Tocumen Intl
JANPTY
Jackson-Evers Intl
Thu 12/24
9:00 am-7:38 pm
1 stop9h 38m
Panama City Tocumen Intl
Thu 12/31
8:55 am-9:59 pm
1 stop14h 04m
$1,279
JacksonPanama City
JAN Jackson-Evers Intl - PTY Panama City Tocumen Intl
JANPTY
Jackson-Evers Intl
Thu 12/24
7:14 pm-1:41 pm
3 stops17h 27m
Panama City Tocumen Intl
Thu 12/31
2:41 pm-8:57 am
3 stops19h 16m
$2,911
JacksonPanama City
JAN Jackson-Evers Intl - PTY Panama City Tocumen Intl
JANPTY
Jackson-Evers Intl
Sat 1/16
2:00 pm-7:49 am
2 stops16h 49m
Panama City Tocumen Intl
Mon 1/25
8:55 am-4:33 pm
1 stop8h 38m
$3,389
Quickest round-trip
JacksonPanama City
JAN Jackson-Evers Intl - PTY Panama City Tocumen Intl
JANPTY
Jackson-Evers Intl
Mon 12/7
11:58 am-7:38 pm
1 stop6h 40m
Panama City Tocumen Intl
Mon 12/14
9:25 am-9:41 pm
2 stops13h 16m
$5,097
JacksonPanama City
JAN Jackson-Evers Intl - PTY Panama City Tocumen Intl
JANPTY
Jackson-Evers Intl
Mon 4/26
7:00 am-8:34 pm
2 stops13h 34m
Panama City Tocumen Intl
Wed 4/28
8:28 am-9:18 pm
2 stops12h 50m
$5,276
Sorted by cheapest first
Best time to book a flight from Mississippi to Panama
Have a flexible travel schedule? Discover the best time to fly to Panama from Mississippi with our price prediction graph.
GPT-PTY
JAN-PTY
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Mississippi to Panama
USMS-PA0
GPT-PTY
JAN-PTY
No data available for this route at this time. Please check back soon.
Related info for your journey
Find useful and relevant information for your journey from Mississippi to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Mississippi to Panama
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Panama by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Mississippi to Panama by cabin class
Find flights from Mississippi to Panama, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Mississippi and Panama flights
Browse other Mississippi and Panama flight options. Last updated on November 9, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from Panama
Find the right flight back to Mississippi after your stay in Panama
Mississippi to Panama flights
Consider these flights traveling from Mississippi to Panama.
Top 2 airlines flying from Mississippi to Panama
Discover the top 2 airlines that operate flights from Mississippi to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 9, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$524 | Average$786 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$786 | Average$1,058 | FlexibilityNo cancel fee | On-timeN/A |