What are the cheapest airlines to fly from Mississippi to Panama one-way?

The cheapest airlines for a one-way flight from Mississippi to Panama are United Airlines ($252), Delta ($272), and American Airlines ($448).

What is the cheapest month to book a flight from Mississippi to Panama?

Currently, October is the cheapest month in which you can book a flight from Mississippi to Panama (average of $478). Flying from Mississippi to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MS to PA?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Mississippi to Panama as you normally would.

Can I find deals for flights from Mississippi to Panama that include hotel bookings?

Yes. In addition to deals on Mississippi to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Mississippi to Panama?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to Panama.

Can I find deals for business class flights from Mississippi to Panama?

Yes. Cheapflights offers flight deals from Mississippi to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$533+ Flights from Mississippi to Panama

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Cheap flight deals from Mississippi to Panama

Round-trip from	$420 (Delta)
One-way from	$252 (United Airlines)

From Mississippi to Panama

Search Deals

One-way flight from Mississippi to Panama

Search Deals

Find flight deals from Mississippi to Panama

Cheapest flights from Mississippi to Panama
Explore the most affordable flight options available from Mississippi to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

Fri 8/17:30 amMEM - PTY

1 stop12h 01mDelta

Sat 8/92:28 pmPTY - MEM

1 stop17h 22mDelta

Deal found 6/11

$420

Mon 10/277:00 amJAN - PTY

1 stop6h 45mUnited Airlines

Mon 11/108:55 amPTY - JAN

1 stop11h 46mUnited Airlines

Deal found 6/10

$467

Thu 7/319:00 amMEM - PTY

1 stop7h 12mUnited Airlines

Thu 8/77:55 amPTY - MEM

1 stop12h 17mUnited Airlines

Deal found 6/11

$489

Fri 8/13:43 pmMEM - PTY

2 stops21h 11mAmerican Airlines

Mon 8/43:10 pmPTY - MEM

2 stops18h 37mAmerican Airlines

Deal found 6/11

$494

Mon 10/276:52 pmJAN - PTY

2 stops17h 33mAmerican Airlines

Mon 11/104:20 pmPTY - JAN

2 stops18h 56mAmerican Airlines

Deal found 6/10

$501

Thu 9/255:00 amMEM - PTY

2 stops19h 10mMultiple Airlines

Sat 9/273:20 amPTY - MEM

2 stops19h 37mMultiple Airlines

Deal found 6/10

$518

Sat 7/269:10 amMOB - PTY

1 stop9h 27mUnited Airlines

Sat 8/23:30 pmPTY - MOB

1 stop30h 05mUnited Airlines

Deal found 6/11

$535

Fri 9/2612:10 pmBTR - PTY

1 stop6h 27mUnited Airlines

Tue 9/303:30 pmPTY - BTR

1 stop7h 52mUnited Airlines

Deal found 6/10

$551

Sat 7/266:01 pmMOB - PTY

2 stops20h 14mAmerican Airlines

Sat 8/23:10 pmPTY - MOB

2 stops26h 21mAmerican Airlines

Deal found 6/11

$552

Fri 8/112:56 pmBTR - PTY

2 stops23h 58mAmerican Airlines

Fri 8/83:30 pmPTY - BTR

2 stops26h 38mAmerican Airlines

Deal found 6/10

$556

Fri 8/16:10 amBTR - PTY

1 stop7h 03mDelta

Fri 8/82:28 pmPTY - BTR

1 stop7h 30mDelta

Deal found 6/10

$571

Mon 6/239:10 amGPT - PTY

1 stop7h 02mUnited Airlines

Sat 7/263:30 pmPTY - GPT

1 stop21h 58mUnited Airlines

Deal found 6/10

$1,048

Best flights from Mississippi to Panama
Discover carefully curated flight deals from Mississippi to Panama that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 12, 2025.

Fri 8/17:30 amMEM - PTY

1 stop12h 01mDelta

Sat 8/92:28 pmPTY - MEM

1 stop17h 22mDelta

Deal found 6/11

$420

Thu 7/319:00 amMEM - PTY

1 stop7h 12mUnited Airlines

Thu 8/77:55 amPTY - MEM

1 stop12h 17mUnited Airlines

Deal found 6/11

$489

Fri 8/13:43 pmMEM - PTY

2 stops21h 11mAmerican Airlines

Mon 8/43:10 pmPTY - MEM

2 stops18h 37mAmerican Airlines

Deal found 6/11

$494

Thu 9/255:00 amMEM - PTY

2 stops19h 10mMultiple Airlines

Sat 9/273:20 amPTY - MEM

2 stops19h 37mMultiple Airlines

Deal found 6/10

$518

Sat 7/199:00 amJAN - PTY

1 stop9h 37mUnited Airlines

Thu 7/2410:00 amPTY - JAN

1 stop11h 59mUnited Airlines

Deal found 6/10

$527

Sat 7/266:01 pmMOB - PTY

2 stops20h 14mAmerican Airlines

Sat 8/23:10 pmPTY - MOB

2 stops26h 21mAmerican Airlines

Deal found 6/11

$552

Fri 8/16:10 amBTR - PTY

1 stop7h 03mDelta

Fri 8/82:28 pmPTY - BTR

1 stop7h 30mDelta

Deal found 6/10

$571

Sat 7/269:10 amMOB - PTY

1 stop9h 27mUnited Airlines

Sat 8/23:30 pmPTY - MOB

1 stop30h 05mUnited Airlines

Deal found 6/11

$535

Fri 8/112:56 pmBTR - PTY

2 stops23h 58mAmerican Airlines

Fri 8/83:30 pmPTY - BTR

2 stops26h 38mAmerican Airlines

Deal found 6/10

$556

Fri 9/267:00 amBTR - PTY

1 stop7h 14mUnited Airlines

Mon 9/2910:00 amPTY - BTR

1 stop13h 22mUnited Airlines

Deal found 6/10

$551

Sat 7/194:28 pmJAN - PTY

2 stops21h 47mAmerican Airlines

Thu 7/241:55 pmPTY - JAN

2 stops18h 58mAmerican Airlines

Deal found 6/10

$582

Mon 6/239:10 amGPT - PTY

1 stop7h 02mUnited Airlines

Sat 7/263:30 pmPTY - GPT

1 stop21h 58mUnited Airlines

Deal found 6/10

$1,048

Last-minute flights from Mississippi to Panama
Discover last-minute flight deals from Mississippi to Panama. Data last updated June 12, 2025 and is based on user searches.

Mon 6/239:10 amGPT - PTY

1 stop7h 02mUnited Airlines

Sat 7/263:30 pmPTY - GPT

1 stop21h 58mUnited Airlines

Deal found 6/10

$1,048

Fri 7/1110:59 amMEM - PTY

1 stop8h 32mDelta

Fri 7/182:28 pmPTY - MEM

1 stop9h 16mDelta

Deal found 6/11

$569

Sun 7/135:34 pmMEM - PTY

2 stops27h 36mMultiple Airlines

Wed 7/163:20 amPTY - MEM

3 stops30h 02mMultiple Airlines

Deal found 6/11

$543

Sat 7/199:00 amJAN - PTY

1 stop9h 37mUnited Airlines

Thu 7/2410:00 amPTY - JAN

1 stop11h 59mUnited Airlines

Deal found 6/10

$527

Sat 7/194:28 pmJAN - PTY

2 stops21h 47mAmerican Airlines

Thu 7/241:55 pmPTY - JAN

2 stops18h 58mAmerican Airlines

Deal found 6/10

$582

Sat 7/269:10 amMOB - PTY

1 stop9h 27mUnited Airlines

Sat 8/23:30 pmPTY - MOB

1 stop30h 05mUnited Airlines

Deal found 6/11

$535

Sat 7/266:01 pmMOB - PTY

2 stops20h 14mAmerican Airlines

Sat 8/23:10 pmPTY - MOB

2 stops26h 21mAmerican Airlines

Deal found 6/11

$552

Sat 7/266:21 pmBTR - PTY

2 stops18h 33mAmerican Airlines

Fri 8/293:30 pmPTY - BTR

2 stops20h 17mAmerican Airlines

Deal found 6/10

$621

Sun 7/274:02 pmBTR - PTY

1 stop22h 12mUnited Airlines

Sun 8/37:55 amPTY - BTR

1 stop15h 29mUnited Airlines

Deal found 6/12

$579

Thu 7/317:00 amMEM - PTY

1 stop11h 37mUnited Airlines

Wed 8/610:00 amPTY - MEM

1 stop12h 14mUnited Airlines

Deal found 6/11

$489

Thu 7/313:43 pmMEM - PTY

2 stops21h 11mAmerican Airlines

Tue 8/51:55 pmPTY - MEM

2 stops19h 08mAmerican Airlines

Deal found 6/11

$581

One-way flights from Mississippi to Panama
Search for one-way flight options from Mississippi to Panama. Find affordable one-way fares based on user searches. Data last updated June 12, 2025.

Tue 7/19:00 amMEM - PTY

1 stop7h 12mUnited Airlines

Deal found 6/12

$252

Sat 7/512:55 pmMEM - PTY

1 stop6h 07mDelta

Deal found 6/10

$272

Mon 6/167:00 amJAN - PTY

1 stop7h 14mUnited Airlines

Deal found 6/11

$311

Mon 6/165:18 pmJAN - PTY

2 stops19h 17mMultiple Airlines

Deal found 6/11

$417

Tue 7/16:05 pmMEM - PTY

2 stops18h 55mAmerican Airlines

Deal found 6/11

$448

Fri 6/205:00 pmJAN - PTY

2 stops20h 00mAmerican Airlines

Deal found 6/10

$531

Cheapflights Fare Finder

Use the filters below to find and compare flights from Mississippi to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

MemphisPanama City

MEM - PTY

MEMPTY

Memphis

Fri 8/1

6:26 am-1:13 pm

1 stop6h 47m

Panama City Tocumen Intl

Sun 8/3

2:28 pm-11:44 pm

1 stop9h 16m

$420

MemphisPanama City

MEM - PTY

MEMPTY

Memphis

Thu 7/31

7:00 am-6:37 pm

1 stop11h 37m

Panama City Tocumen Intl

Wed 8/6

10:00 am-10:14 pm

1 stop12h 14m

$489

MemphisPanama City

MEM - PTY

MEMPTY

Memphis

Fri 8/1

3:43 pm-12:54 pm

2 stops21h 11m

Panama City Tocumen Intl

Mon 8/4

3:10 pm-9:47 am

2 stops18h 37m

$494

MemphisPanama City

MEM - PTY

MEMPTY

Memphis

Thu 9/25

5:00 am-12:10 am

2 stops19h 10m

Panama City Tocumen Intl

Sat 9/27

3:20 am-10:57 pm

2 stops19h 37m

$518

JacksonPanama City

JAN - PTY

JANPTY

Jackson-Evers Intl

Sat 7/19

9:00 am-6:37 pm

1 stop9h 37m

Panama City Tocumen Intl

Thu 7/24

10:00 am-9:59 pm

1 stop11h 59m

$527

MobilePanama City

MOB - PTY

MOBPTY

Mobile

Sat 7/26

9:10 am-6:37 pm

1 stop9h 27m

Panama City Tocumen Intl

Sat 8/2

3:30 pm-9:35 pm

1 stop30h 05m

$535

Baton RougePanama City

BTR - PTY

BTRPTY

Baton Rouge Ryan

Fri 9/26

12:10 pm-6:37 pm

1 stop6h 27m

Panama City Tocumen Intl

Tue 9/30

3:30 pm-11:22 pm

1 stop7h 52m

$551

MobilePanama City

MOB - PTY

MOBPTY

Mobile

Sat 7/26

6:01 pm-2:15 pm

2 stops20h 14m

Panama City Tocumen Intl

Sat 8/2

3:10 pm-5:31 pm

2 stops26h 21m

$552

Baton RougePanama City

BTR - PTY

BTRPTY

Baton Rouge Ryan

Fri 8/1

12:56 pm-12:54 pm

2 stops23h 58m

Panama City Tocumen Intl

Fri 8/8

3:30 pm-6:08 pm

2 stops26h 38m

$556

Baton RougePanama City

BTR - PTY

BTRPTY

Baton Rouge Ryan

Fri 8/1

6:10 am-1:13 pm

1 stop7h 03m

Panama City Tocumen Intl

Fri 8/8

2:28 pm-9:58 pm

1 stop7h 30m

$571

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/12

Showing 1-10 of 18 results

Best time to book a flight from Mississippi to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Mississippi with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to Panama

Rainfall in Panama by month

In terms of precipitation, rainfall in Panama ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama when rainfall is around 0.4 in.

Temperature in Panama by month

If weather is an important factor for your trip to Panama, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

Reviews of airlines servicing Panama

Get a feel of what it's like to fly with Delta, United Airlines and American Airlines from Mississippi to Panama by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,946 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Delta

8.0

Very good

7,946 reviews

Delta

8.0

Very good

7,946 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

United Airlines

7.4

Good

8,790 reviews

Delta

8.0

Very good

7,946 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,946 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

What are the cheapest airlines to fly from Mississippi to Panama one-way?
The cheapest airlines for a one-way flight from Mississippi to Panama are United Airlines ($252), Delta ($272), and American Airlines ($448).
Can I find deals for flights from Mississippi to Panama that include hotel bookings?
Yes. In addition to deals on Mississippi to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Mississippi to Panama?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to Panama.
Can I find deals for business class flights from Mississippi to Panama?
Yes. Cheapflights offers flight deals from Mississippi to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Mississippi to Panama?
Currently, October is the cheapest month in which you can book a flight from Mississippi to Panama (average of $478). Flying from Mississippi to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Alternative routes for Mississippi to Panama

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Top 2 airlines flying from Mississippi to Panama

Airline	Cheapest	Average	Flexibility	On-time
Delta	Cheapest$377	Average$417	FlexibilityNo cancel fee	On-timeN/A
United Airlines	Cheapest$417	Average$570	FlexibilityNo cancel fee	On-time69%

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$252+ Cheap flights from Mississippi to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/1. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Mississippi to Panama with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Mississippi to Panama

Keep the following information in mind while searching for Mississippi to Panama flight deals. Data was last updated June 12, 2025.

Round-trip from

One-way from

Find flight deals from Mississippi to Panama

Cheapest flights from Mississippi to PanamaExplore the most affordable flight options available from Mississippi to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

Explore the most affordable flight options available from Mississippi to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Mississippi to Panama that are best for you.

Best time to book a flight from Mississippi to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Mississippi with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to Panama

Rainfall in Panama by month

Plan your trip to Panama by taking into account the average rainfall totals by month.

Temperature in Panama by month

Plan your trip to Panama by taking into account the average temperature totals by month.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated June 12, 2025.

Get a feel of what it's like to fly with Delta, United Airlines and American Airlines from Mississippi to Panama by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Mississippi to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines to fly from Mississippi to Panama one-way?

Can I find deals for flights from Mississippi to Panama that include hotel bookings?

How can I find direct flights from Mississippi to Panama?

Can I find deals for business class flights from Mississippi to Panama?

What is the cheapest month to book a flight from Mississippi to Panama?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Mississippi to Panama

See prices for flight routes from nearby airports that may be better suited for you.

Top 2 airlines flying from Mississippi to Panama

100% Free

Book with Flexibility

Travel Smart

Cheapest flights from Mississippi to Panama
Explore the most affordable flight options available from Mississippi to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.