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$241+ Cheap flights from Mississippi to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/18. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — PTY
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheap flight deals from Mississippi to Panama

Keep the following information in mind while searching for Mississippi to Panama flight deals. Data was last updated September 15, 2025.

Round-trip from

$492
(American Airlines)

One-way from

$241
(United Airlines)
From Mississippi to Panama
Search Deals
One-way flight from Mississippi to Panama
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Find flight deals from Mississippi to Panama

Cheapest flights from Mississippi to Panama
Explore the most affordable flight options available from Mississippi to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/307:06 pmGPT - PTY
2 stops18h 57mAmerican Airlines
Thu 11/62:49 pmPTY - GPT
2 stops27h 51mAmerican Airlines
Deal found 9/15$492
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/59:15 amJAN - PTY
2 stops27h 34mAmerican Airlines
Tue 11/112:49 pmPTY - JAN
2 stops18h 55mAmerican Airlines
Deal found 9/14$492
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/307:00 amMOB - PTY
1 stop6h 45mUnited Airlines
Thu 11/68:55 amPTY - MOB
1 stop13h 54mUnited Airlines
Deal found 9/14$506
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/307:05 amGPT - PTY
1 stop6h 40mUnited Airlines
Thu 11/68:55 amPTY - GPT
1 stop8h 07mUnited Airlines
Deal found 9/14$506
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/1311:30 amMOB - PTY
1 stop7h 07mUnited Airlines
Thu 10/2310:00 amPTY - MOB
1 stop8h 49mUnited Airlines
Deal found 9/14$507
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/205:32 amJAN - PTY
1 stop7h 24mDelta
Thu 10/302:21 pmPTY - JAN
1 stop8h 29mDelta
Deal found 9/14$507
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2811:37 amMEM - PTY
1 stop7h 01mUnited Airlines
Tue 11/44:41 pmPTY - MEM
1 stop17h 31mUnited Airlines
Deal found 9/13$509
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/206:15 pmJAN - PTY
2 stops19h 48mAmerican Airlines
Tue 10/283:15 pmPTY - JAN
2 stops18h 17mAmerican Airlines
Deal found 9/15$512
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/283:47 pmMEM - PTY
2 stops22h 16mAmerican Airlines
Tue 11/42:49 pmPTY - MEM
2 stops19h 55mAmerican Airlines
Deal found 9/13$514
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/1311:30 amMOB - PTY
1 stop7h 07mUnited Airlines
Mon 10/203:30 pmPTY - MOB
1 stop20h 13mUnited Airlines
Deal found 9/14$515
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/121:17 pmMOB - PTY
1 stop23h 39mDelta
Thu 10/232:21 pmPTY - MOB
1 stop18h 12mDelta
Deal found 9/14$522
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/169:20 amMOB - PTY
1 stop9h 17mUnited Airlines
Tue 10/2110:00 amPTY - MOB
1 stop8h 49mUnited Airlines
Deal found 9/14$526

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mississippi to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Mississippi to Panama that are best for you.

Fly from

Mississippi

Fly to

Panama

Route

Depart

Return

Price

GulfportPanama City

GPT - PTY

GPTPTY

Gulfport Biloxi Regional

Thu 10/30

7:06 pm-2:03 pm

2 stops18h 57m

Panama City Tocumen Intl

Thu 11/6

2:49 pm-5:40 pm

2 stops27h 51m

$492

MobilePanama City

MOB - PTY

MOBPTY

Mobile

Thu 10/30

7:00 am-1:45 pm

1 stop6h 45m

Panama City Tocumen Intl

Thu 11/6

8:55 am-9:49 pm

1 stop13h 54m

$506

GulfportPanama City

GPT - PTY

GPTPTY

Gulfport Biloxi Regional

Thu 10/30

7:05 am-1:45 pm

1 stop6h 40m

Panama City Tocumen Intl

Thu 11/6

8:55 am-4:02 pm

1 stop8h 07m

$506

MobilePanama City

MOB - PTY

MOBPTY

Mobile

Mon 10/13

5:43 am-12:56 pm

1 stop7h 13m

Panama City Tocumen Intl

Wed 10/22

2:21 pm-10:48 pm

1 stop8h 27m

$507

JacksonPanama City

JAN - PTY

JANPTY

Jackson-Evers Intl

Tue 10/21

5:32 am-12:56 pm

1 stop7h 24m

Panama City Tocumen Intl

Wed 10/29

2:21 pm-10:50 pm

1 stop8h 29m

$507

MobilePanama City

MOB - PTY

MOBPTY

Mobile

Mon 10/13

7:00 am-2:14 pm

1 stop7h 14m

Panama City Tocumen Intl

Thu 10/23

10:00 am-6:49 pm

1 stop8h 49m

$507

MobilePanama City

MOB - PTY

MOBPTY

Mobile

Tue 10/14

7:00 am-6:37 pm

1 stop11h 37m

Panama City Tocumen Intl

Wed 10/22

10:00 am-6:49 pm

1 stop8h 49m

$507

MobilePanama City

MOB - PTY

MOBPTY

Mobile

Tue 10/14

7:00 am-6:37 pm

1 stop11h 37m

Panama City Tocumen Intl

Tue 10/21

10:00 am-6:49 pm

1 stop8h 49m

$507

MobilePanama City

MOB - PTY

MOBPTY

Mobile

Wed 10/15

7:00 am-6:37 pm

1 stop11h 37m

Panama City Tocumen Intl

Wed 10/22

10:00 am-6:49 pm

1 stop8h 49m

$507

MobilePanama City

MOB - PTY

MOBPTY

Mobile

Mon 10/13

11:30 am-6:37 pm

1 stop7h 07m

Panama City Tocumen Intl

Tue 10/21

10:00 am-6:49 pm

1 stop8h 49m

$507

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Showing 1-10 of 36 results
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Best time to book a flight from Mississippi to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Mississippi with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to Panama
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Mississippi to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Mississippi to Panama?

    For as low as $506, American Airlines can have you in Panama from Mississippi in 6h 45m. Airlines will cover a distance of 1598 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Mississippi to Panama one-way?

    The cheapest airlines for a one-way flight from Mississippi to Panama are American Airlines ($241), United Airlines ($241), and Delta ($293).

  • Can I find deals for flights from Mississippi to Panama that include hotel bookings?

    Yes. In addition to deals on Mississippi to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mississippi to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to Panama.

  • Can I find deals for business class flights from Mississippi to Panama?

    Yes. Cheapflights offers flight deals from Mississippi to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mississippi to Panama?

    Currently, October is the cheapest month in which you can book a flight from Mississippi to Panama (average of $478). Flying from Mississippi to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Mississippi to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Baltimore to San José flights
San Francisco to San José flights
Reagan-National to San José flights
LaGuardia to Guatemala City flights
Reagan-National to San Salvador flights
Atlanta to San Salvador flights
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O'Hare Intl to Liberia flights
Miami to San José flights
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Top airline flying from Mississippi to Panama

Discover the top airline that operate flights from Mississippi to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$445Average$611FlexibilityNo cancel feeOn-time69%

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