How long is the flight from Mississippi to Panama?

For as low as $456, United Airlines can have you in Panama from Mississippi in 7h 07m. Airlines will cover a distance of 1598 mi. This flight may include one or multiple stops.

In terms of precipitation, rainfall in Panama ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama when rainfall is around 0.4 in.

If weather is an important factor for your trip to Panama, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

What is the cheapest time of day to fly from MS to PA?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Mississippi to Panama as you normally would.

Can I find deals for flights from Mississippi to Panama that include hotel bookings?

Yes. In addition to deals on Mississippi to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Mississippi to Panama?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to Panama.

Can I find deals for business class flights from Mississippi to Panama?

Yes. Cheapflights offers flight deals from Mississippi to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$225+ Flights from Mississippi to Panama

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Cheap flight deals from Mississippi to Panama

Cheapest flights from Mississippi to Panama
Explore the most affordable flight options available from Mississippi to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

Thu 12/256:30 amMEM - PTY

1 stop12h 08mUnited Airlines

Sun 12/288:55 amPTY - MEM

1 stop10h 21mUnited Airlines

Deal found 12/16

$719

Thu 12/255:12 pmMEM - PTY

2 stops21h 42mAmerican Airlines

Sun 12/284:55 pmPTY - MEM

1 stop8h 45mAmerican Airlines

Deal found 12/16

$832

Wed 12/246:30 amMEM - PTY

1 stop12h 08mUnited Airlines

Sat 1/38:55 amPTY - MEM

1 stop13h 51mUnited Airlines

Deal found 12/16

$1,182

Wed 12/249:15 amMEM - PTY

2 stops27h 38mAmerican Airlines

Sat 1/32:53 pmPTY - MEM

2 stops20h 32mAmerican Airlines

Deal found 12/17

$1,231

Mon 12/297:00 amGPT - PTY

1 stop9h 07mUnited Airlines

Thu 1/84:41 pmPTY - GPT

1 stop21h 41mUnited Airlines

Deal found 12/17

$1,300

Sat 12/206:45 pmMOB - PTY

2 stops20h 09mAmerican Airlines

Sun 1/44:55 pmPTY - MOB

2 stops18h 30mAmerican Airlines

Deal found 12/16

$1,414

Sat 12/207:00 amMOB - PTY

1 stop6h 45mUnited Airlines

Sun 1/44:41 pmPTY - MOB

1 stop20h 43mUnited Airlines

Deal found 12/17

$1,416

Mon 12/294:48 pmGPT - PTY

2 stops22h 06mAmerican Airlines

Thu 1/84:50 pmPTY - GPT

2 stops26h 13mAmerican Airlines

Deal found 12/17

$1,478

Fri 12/196:20 amMOB - PTY

1 stop12h 39mDelta

Sun 1/48:00 amPTY - MOB

1 stop16h 11mDelta

Deal found 12/17

$1,483

Fri 12/196:45 pmMOB - PTY

2 stops20h 09mAmerican Airlines

Sun 1/44:55 pmPTY - MOB

2 stops18h 30mAmerican Airlines

Deal found 12/17

$1,536

Best flights from Mississippi to Panama
Discover carefully curated flight deals from Mississippi to Panama that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 18, 2025.

Sat 2/289:00 amMOB - PTY

1 stop7h 07mUnited Airlines

Wed 3/48:55 amPTY - MOB

1 stop8h 18mUnited Airlines

Deal found 12/15

$456

Wed 2/111:03 pmGPT - PTY

2 stops23h 47mAmerican Airlines

Wed 2/182:50 pmPTY - GPT

2 stops20h 26mAmerican Airlines

Deal found 12/16

$480

Wed 1/216:18 amBTR - PTY

1 stop6h 37mDelta

Tue 1/273:20 pmPTY - BTR

1 stop7h 41mDelta

Deal found 12/17

$622

Sat 2/75:13 pmGPT - PTY

1 stop20h 32mUnited Airlines

Wed 2/118:55 amPTY - GPT

1 stop8h 03mUnited Airlines

Deal found 12/17

$463

Sat 1/315:34 pmGPT - PTY

2 stops18h 53mAmerican Airlines

Sat 2/75:00 pmPTY - GPT

2 stops20h 31mAmerican Airlines

Deal found 12/17

$500

Tue 2/37:00 amJAN - PTY

1 stop11h 38mUnited Airlines

Sat 2/74:41 pmPTY - JAN

1 stop21h 41mUnited Airlines

Deal found 12/15

$463

Sat 1/106:33 pmGPT - PTY

2 stops17h 54mAmerican Airlines

Fri 1/304:50 pmPTY - GPT

2 stops26h 13mAmerican Airlines

Deal found 12/17

$520

Mon 1/261:57 pmGPT - PTY

1 stop26h 10mUnited Airlines

Thu 1/298:55 amPTY - GPT

1 stop11h 53mUnited Airlines

Deal found 12/15

$483

Sat 1/2412:01 pmJAN - PTY

1 stop6h 37mUnited Airlines

Wed 1/288:55 amPTY - JAN

1 stop8h 07mUnited Airlines

Deal found 12/16

$496

Fri 1/94:17 pmMEM - PTY

2 stops20h 10mAmerican Airlines

Fri 1/164:50 pmPTY - MEM

1 stop8h 03mAmerican Airlines

Deal found 12/16

$574

Sat 1/315:13 pmGPT - PTY

1 stop22h 54mUnited Airlines

Sat 2/74:41 pmPTY - GPT

1 stop21h 41mUnited Airlines

Deal found 12/17

$511

Fri 1/306:47 pmBTR - PTY

2 stops20h 05mAmerican Airlines

Fri 2/64:50 pmPTY - BTR

2 stops25h 11mAmerican Airlines

Deal found 12/15

$576

Sun 1/255:00 pmMEM - PTY

1 stop23h 07mUnited Airlines

Thu 1/298:55 amPTY - MEM

1 stop14h 03mUnited Airlines

Deal found 12/15

$538

Wed 1/141:27 pmMEM - PTY

2 stops23h 00mAmerican Airlines

Wed 1/212:27 pmPTY - MEM

2 stops20h 14mAmerican Airlines

Deal found 12/16

$629

Sat 1/105:13 pmGPT - PTY

1 stop22h 54mUnited Airlines

Fri 1/308:55 amPTY - GPT

1 stop8h 03mUnited Airlines

Deal found 12/17

$544

Fri 4/35:57 pmBTR - PTY

2 stops18h 43mAmerican Airlines

Tue 4/71:55 pmPTY - BTR

2 stops19h 47mAmerican Airlines

Deal found 12/17

$631

Fri 1/306:15 amMEM - PTY

1 stop12h 23mUnited Airlines

Fri 2/64:41 pmPTY - MEM

1 stop17h 32mUnited Airlines

Deal found 12/15

$550

Wed 2/184:30 pmBTR - PTY

2 stops21h 45mAmerican Airlines

Sun 2/224:05 pmPTY - BTR

2 stops24h 54mAmerican Airlines

Deal found 12/16

$631

Fri 4/35:00 amBTR - PTY

1 stop11h 12mUnited Airlines

Tue 4/77:55 amPTY - BTR

1 stop11h 38mUnited Airlines

Deal found 12/17

$552

Wed 2/189:30 amBTR - PTY

1 stop6h 37mUnited Airlines

Sun 2/224:41 pmPTY - BTR

1 stop23h 52mUnited Airlines

Deal found 12/16

$559

Sun 1/185:15 pmBTR - PTY

1 stop25h 23mUnited Airlines

Thu 1/228:55 amPTY - BTR

1 stop8h 03mUnited Airlines

Deal found 12/15

$579

Wed 2/115:13 pmGPT - PTY

1 stop25h 25mUnited Airlines

Wed 2/184:41 pmPTY - GPT

1 stop21h 39mUnited Airlines

Deal found 12/16

$598

Fri 1/309:30 amBTR - PTY

1 stop9h 08mUnited Airlines

Fri 2/64:41 pmPTY - BTR

1 stop19h 44mUnited Airlines

Deal found 12/15

$599

Wed 1/146:15 amMEM - PTY

1 stop7h 30mUnited Airlines

Wed 1/218:55 amPTY - MEM

1 stop8h 14mUnited Airlines

Deal found 12/16

$651

Wed 1/2110:32 amBTR - PTY

2 stops21h 48mWestJet

Tue 1/2710:20 amPTY - BTR

2 stops48h 32mWestJet

Deal found 12/17

$5,344

Tue 2/39:28 amJAN - PTY

2 stops46h 52mWestJet

Sat 2/710:20 amPTY - JAN

2 stops33h 30mWestJet

Deal found 12/15

$5,387

Last-minute flights from Mississippi to Panama
Discover last-minute flight deals from Mississippi to Panama. Data last updated December 18, 2025 and is based on user searches.

Fri 1/94:17 pmMEM - PTY

2 stops20h 10mAmerican Airlines

Fri 1/164:50 pmPTY - MEM

1 stop8h 03mAmerican Airlines

Deal found 12/16

$574

Sat 1/106:33 pmGPT - PTY

2 stops17h 54mAmerican Airlines

Fri 1/304:50 pmPTY - GPT

2 stops26h 13mAmerican Airlines

Deal found 12/17

$520

Sat 1/105:13 pmGPT - PTY

1 stop22h 54mUnited Airlines

Fri 1/308:55 amPTY - GPT

1 stop8h 03mUnited Airlines

Deal found 12/17

$544

Sun 1/185:15 pmBTR - PTY

1 stop25h 23mUnited Airlines

Thu 1/228:55 amPTY - BTR

1 stop8h 03mUnited Airlines

Deal found 12/15

$579

Sat 1/2412:01 pmJAN - PTY

1 stop6h 37mUnited Airlines

Wed 1/288:55 amPTY - JAN

1 stop8h 07mUnited Airlines

Deal found 12/16

$496

Sun 1/255:00 pmMEM - PTY

1 stop23h 07mUnited Airlines

Thu 1/298:55 amPTY - MEM

1 stop14h 03mUnited Airlines

Deal found 12/15

$538

Mon 1/261:57 pmGPT - PTY

1 stop26h 10mUnited Airlines

Thu 1/298:55 amPTY - GPT

1 stop11h 53mUnited Airlines

Deal found 12/15

$483

Fri 1/306:15 amMEM - PTY

1 stop12h 23mUnited Airlines

Fri 2/64:41 pmPTY - MEM

1 stop17h 32mUnited Airlines

Deal found 12/15

$550

Fri 1/306:47 pmBTR - PTY

2 stops20h 05mAmerican Airlines

Fri 2/64:50 pmPTY - BTR

2 stops25h 11mAmerican Airlines

Deal found 12/15

$576

Fri 1/309:30 amBTR - PTY

1 stop9h 08mUnited Airlines

Fri 2/64:41 pmPTY - BTR

1 stop19h 44mUnited Airlines

Deal found 12/15

$599

Sat 1/315:34 pmGPT - PTY

2 stops18h 53mAmerican Airlines

Sat 2/75:00 pmPTY - GPT

2 stops20h 31mAmerican Airlines

Deal found 12/17

$500

Sat 1/315:13 pmGPT - PTY

1 stop22h 54mUnited Airlines

Sat 2/74:41 pmPTY - GPT

1 stop21h 41mUnited Airlines

Deal found 12/17

$511

One-way flights from Mississippi to Panama
Search for one-way flight options from Mississippi to Panama. Find affordable one-way fares based on user searches. Data last updated December 18, 2025.

Sat 5/3012:00 pmJAN - PTY

1 stop6h 37mUnited Airlines

Deal found 12/15

$225

Sat 5/3010:01 amJAN - PTY

2 stops26h 24mAmerican Airlines

Deal found 12/15

$231

Sat 5/307:05 pmMEM - PTY

2 stops17h 20mAmerican Airlines

Deal found 12/15

$252

Sat 5/303:15 pmMEM - PTY

1 stop27h 22mUnited Airlines

Deal found 12/15

$267

Thu 12/256:00 amMEM - PTY

1 stop6h 57mDelta

Deal found 12/17

$306

Thu 12/256:30 amMEM - PTY

1 stop7h 15mUnited Airlines

Deal found 12/16

$311

Sat 5/3012:24 pmMEM - PTY

3 stops32h 46mMultiple Airlines

Deal found 12/15

$369

Thu 12/255:12 pmMEM - PTY

2 stops19h 41mAmerican Airlines

Deal found 12/17

$464

Find flight deals from Mississippi to Panama

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$448 (American Airlines)
One-way from	$225 (United Airlines)

Provider with most accurate pricing for Jackson-Evers Intl-Panama City Tocumen Intl flight deals.

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From Mississippi to Panama

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One-way flight from Mississippi to Panama

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Cheapflights Fare Finder

Use the filters below to find and compare flights from Mississippi to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

MobilePanama City

MOB - PTY

MOBPTY

Mobile

Sat 2/28

9:00 am-5:07 pm

1 stop7h 07m

Panama City Tocumen Intl

Wed 3/4

8:55 am-4:13 pm

1 stop8h 18m

$456

GulfportPanama City

GPT - PTY

GPTPTY

Gulfport Biloxi Regional

Sat 2/7

5:13 pm-2:45 pm

1 stop20h 32m

Panama City Tocumen Intl

Wed 2/11

8:55 am-3:58 pm

1 stop8h 03m

$463

JacksonPanama City

JAN - PTY

JANPTY

Jackson-Evers Intl

Tue 2/3

7:00 am-7:38 pm

1 stop11h 38m

Panama City Tocumen Intl

Sat 2/7

4:41 pm-1:22 pm

1 stop21h 41m

$463

GulfportPanama City

GPT - PTY

GPTPTY

Gulfport Biloxi Regional

Wed 2/11

1:03 pm-1:50 pm

2 stops23h 47m

Panama City Tocumen Intl

Wed 2/18

2:50 pm-10:16 am

2 stops20h 26m

$480

GulfportPanama City

GPT - PTY

GPTPTY

Gulfport Biloxi Regional

Mon 1/26

1:57 pm-5:07 pm

1 stop26h 10m

Panama City Tocumen Intl

Thu 1/29

8:55 am-7:48 pm

1 stop11h 53m

$483

JacksonPanama City

JAN - PTY

JANPTY

Jackson-Evers Intl

Sat 1/24

12:01 pm-7:38 pm

1 stop6h 37m

Panama City Tocumen Intl

Wed 1/28

8:55 am-4:02 pm

1 stop8h 07m

$496

GulfportPanama City

GPT - PTY

GPTPTY

Gulfport Biloxi Regional

Sat 1/31

5:34 pm-1:27 pm

2 stops18h 53m

Panama City Tocumen Intl

Sat 2/7

5:00 pm-12:31 pm

2 stops20h 31m

$500

GulfportPanama City

GPT - PTY

GPTPTY

Gulfport Biloxi Regional

Sat 1/31

5:13 pm-5:07 pm

1 stop22h 54m

Panama City Tocumen Intl

Sat 2/7

4:41 pm-1:22 pm

1 stop21h 41m

$511

GulfportPanama City

GPT - PTY

GPTPTY

Gulfport Biloxi Regional

Sat 1/10

6:33 pm-1:27 pm

2 stops17h 54m

Panama City Tocumen Intl

Fri 1/30

4:50 pm-6:03 pm

2 stops26h 13m

$520

MemphisPanama City

MEM - PTY

MEMPTY

Memphis

Sun 1/25

5:00 pm-5:07 pm

1 stop23h 07m

Panama City Tocumen Intl

Thu 1/29

8:55 am-9:58 pm

1 stop14h 03m

$538

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/15

Showing 1-10 of 34 results

Best time to book a flight from Mississippi to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Mississippi with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to Panama

No data available for this route at this time. Please check back soon.

Related info for your journey

How long is the flight from Mississippi to Panama?
For as low as $456, United Airlines can have you in Panama from Mississippi in 7h 07m. Airlines will cover a distance of 1598 mi. This flight may include one or multiple stops.
Can I find deals for flights from Mississippi to Panama that include hotel bookings?
Yes. In addition to deals on Mississippi to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Mississippi to Panama?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to Panama.
Can I find deals for business class flights from Mississippi to Panama?
Yes. Cheapflights offers flight deals from Mississippi to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Alternative routes for Mississippi to Panama

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O'Hare Intl to Liberia flights

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Top airline flying from Mississippi to Panama

Airline	Cheapest	Average	Flexibility	On-time
United Airlines	Cheapest$445	Average$609	FlexibilityNo cancel fee	On-time69%

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$225+ Cheap flights from Mississippi to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/30. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Mississippi to Panama with Cheapflights

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Cheap flight deals from Mississippi to Panama

Cheapest flights from Mississippi to PanamaExplore the most affordable flight options available from Mississippi to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

Explore the most affordable flight options available from Mississippi to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

Find flight deals from Mississippi to Panama

Keep the following information in mind while searching for Mississippi to Panama flight deals. Data was last updated December 18, 2025.

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Cheapflights Fare Finder

Use the filters below to find and compare flights from Mississippi to Panama that are best for you.

Best time to book a flight from Mississippi to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Mississippi with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to Panama

Related info for your journey

Find useful and relevant information for your journey from Mississippi to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from Mississippi to Panama?

Can I find deals for flights from Mississippi to Panama that include hotel bookings?

How can I find direct flights from Mississippi to Panama?

Can I find deals for business class flights from Mississippi to Panama?

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Mississippi to Panama

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Top airline flying from Mississippi to Panama

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Cheapest flights from Mississippi to Panama
Explore the most affordable flight options available from Mississippi to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.