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$222+ Cheap flights from Mississippi to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/28. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — PTY
mai 6 — mai 131
ter 5/6
ter 5/13
1 adult, Economy
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Cheap flight deals from Mississippi to Panama

Keep the following information in mind while searching for Mississippi to Panama flight deals. Data was last updated maio 1, 2025.

Most accurate provider

AranGrant
3 stars

Most trusted provider

AranGrant
3 stars

Round-trip from

$422
(United Airlines)

One-way from

$222
(Delta)
Provider with most accurate pricing for Jackson-Evers Intl-Panama City Tocumen Intl flight deals.
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Provider most trusted by Cheapflights users for Jackson-Evers Intl-Panama City Tocumen Intl flights.
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From Mississippi to Panama
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One-way flight from Mississippi to Panama
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Find flight deals from Mississippi to Panama

Cheapest flights from Mississippi to Panama
Explore the most affordable flight options available from Mississippi to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on maio 1, 2025.

This United Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
qua 7/235:25 pmGPT - PTY
1 stop22h 47mUnited Airlines
seg 7/287:55 amPTY - GPT
1 stop8h 19mUnited Airlines
Deal found 4/30$422
This United Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
qua 7/239:10 amMOB - PTY
1 stop9h 27mUnited Airlines
dom 7/273:30 pmPTY - MOB
1 stop30h 05mUnited Airlines
Deal found 4/30$438
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
qua 7/236:36 pmGPT - PTY
2 stops18h 18mAmerican Airlines
seg 7/283:10 pmPTY - GPT
2 stops26h 50mAmerican Airlines
Deal found 4/30$480
This United Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
seg 6/26:45 amMEM - PTY
1 stop9h 27mUnited Airlines
qui 7/310:00 amPTY - MEM
1 stop12h 14mUnited Airlines
Deal found 4/30$489
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
qua 5/282:26 pmMEM - PTY
2 stops21h 53mAmerican Airlines
qui 7/31:50 pmPTY - MEM
2 stops22h 47mAmerican Airlines
Deal found 4/30$494
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sex 6/135:00 pmJAN - PTY
2 stops21h 25mAmerican Airlines
dom 6/153:20 pmPTY - JAN
2 stops20h 59mAmerican Airlines
Deal found 4/29$500
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sex 6/139:00 amJAN - PTY
1 stop9h 37mUnited Airlines
dom 6/153:30 pmPTY - JAN
1 stop19h 59mUnited Airlines
Deal found 4/29$503
This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
qua 6/46:00 amMEM - PTY
1 stop6h 48mDelta
ter 7/12:23 pmPTY - MEM
1 stop21h 00mDelta
Deal found 4/30$517
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
seg 5/126:51 pmMOB - PTY
2 stops17h 28mAmerican Airlines
dom 5/181:20 pmPTY - MOB
2 stops22h 50mAmerican Airlines
Deal found 4/30$550
This United Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb 6/149:45 amBTR - PTY
1 stop8h 52mUnited Airlines
sáb 6/213:30 pmPTY - BTR
1 stop17h 29mUnited Airlines
Deal found 4/30$571
This Mytrip deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
seg 6/99:16 amMEM - PTY
3 stops38h 54mMultiple Airlines
qua 6/183:20 amPTY - MEM
2 stops30h 05mMultiple Airlines
Deal found 5/1$610
This American Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
qui 5/224:32 pmBTR - PTY
2 stops19h 47mAmerican Airlines
seg 5/261:20 pmPTY - BTR
2 stops26h 40mAmerican Airlines
Deal found 5/1$716

Cheapflights Fare Finder

Customize your flight search to find flights from Mississippi to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated maio 1, 2025.
Use the filters below to find and compare flights from Mississippi to Panama that are best for you.

Fly from

Mississippi

Fly to

Panama

Route

Depart

Return

Price

GulfportPanama City

GPT - PTY

GPTPTY

Gulfport Biloxi Regional

qua 7/23

5:25 pm-4:12 pm

1 stop22h 47m

Panama City Tocumen Intl

seg 7/28

7:55 am-4:14 pm

1 stop8h 19m

$422

MobilePanama City

MOB - PTY

MOBPTY

Mobile

qua 7/23

9:10 am-6:37 pm

1 stop9h 27m

Panama City Tocumen Intl

dom 7/27

3:30 pm-9:35 pm

1 stop30h 05m

$438

GulfportPanama City

GPT - PTY

GPTPTY

Gulfport Biloxi Regional

qua 7/23

6:36 pm-12:54 pm

2 stops18h 18m

Panama City Tocumen Intl

seg 7/28

3:10 pm-6:00 pm

2 stops26h 50m

$480

MemphisPanama City

MEM - PTY

MEMPTY

Memphis

seg 6/2

6:45 am-4:12 pm

1 stop9h 27m

Panama City Tocumen Intl

ter 7/1

3:30 pm-9:12 am

1 stop17h 42m

$489

MemphisPanama City

MEM - PTY

MEMPTY

Memphis

qua 5/28

2:26 pm-12:19 pm

2 stops21h 53m

Panama City Tocumen Intl

qui 7/3

1:50 pm-12:37 pm

2 stops22h 47m

$494

JacksonPanama City

JAN - PTY

JANPTY

Jackson-Evers Intl

sex 6/13

5:00 pm-2:25 pm

2 stops21h 25m

Panama City Tocumen Intl

dom 6/15

3:20 pm-12:19 pm

2 stops20h 59m

$500

JacksonPanama City

JAN - PTY

JANPTY

Jackson-Evers Intl

sex 6/13

9:00 am-6:37 pm

1 stop9h 37m

Panama City Tocumen Intl

dom 6/15

3:30 pm-11:29 am

1 stop19h 59m

$503

MemphisPanama City

MEM - PTY

MEMPTY

Memphis

qua 6/4

6:00 am-12:48 pm

1 stop6h 48m

Panama City Tocumen Intl

ter 7/1

2:23 pm-11:23 am

1 stop21h 00m

$517

MobilePanama City

MOB - PTY

MOBPTY

Mobile

seg 5/12

6:51 pm-12:19 pm

2 stops17h 28m

Panama City Tocumen Intl

dom 5/18

1:20 pm-12:10 pm

2 stops22h 50m

$550

Baton RougePanama City

BTR - PTY

BTRPTY

Baton Rouge Ryan

sáb 6/14

9:45 am-6:37 pm

1 stop8h 52m

Panama City Tocumen Intl

sáb 6/21

3:30 pm-8:59 am

1 stop17h 29m

$571

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/30

Showing 1-10 of 18 results
1
2

Best time to book a flight from Mississippi to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Mississippi with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to Panama

Rainfall in Panama by month

Plan your trip to Panama by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Panama ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama when rainfall is around 0.4 in.

Temperature in Panama by month

Plan your trip to Panama by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Panama, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated maio 1, 2025.
Get a feel of what it's like to fly with Delta, United Airlines and American Airlines from Mississippi to Panama by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,934 reviews

Crew

8.5

Overall

8.0

Food

7.3

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Delta
8.0
Very good
7,934 reviews
Delta
8.0
Very good
7,934 reviews

Crew

8.5

Overall

8.0

Food

7.3

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
United Airlines
7.4
Good
8,696 reviews
Delta
8.0
Very good
7,934 reviews

Crew

8.5

Overall

8.0

Food

7.3

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,934 reviews

Crew

8.5

Overall

8.0

Food

7.3

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from Mississippi to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines to fly from Mississippi to Panama one-way?

    The cheapest airlines for a one-way flight from Mississippi to Panama are Delta ($222), United Airlines ($243), and American Airlines ($301).

  • Can I find deals for flights from Mississippi to Panama that include hotel bookings?

    Yes. In addition to deals on Mississippi to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mississippi to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to Panama.

  • Can I find deals for business class flights from Mississippi to Panama?

    Yes. Cheapflights offers flight deals from Mississippi to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mississippi to Panama?

    Currently, October is the cheapest month in which you can book a flight from Mississippi to Panama (average of $478). Flying from Mississippi to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Mississippi to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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John F Kennedy Intl to San José flights
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Atlanta to Panama City flights
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Miami to Managua flights
Reagan-National to San Salvador flights
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Denver to Liberia flights
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Top 2 airlines flying from Mississippi to Panama

Discover the top 2 airlines that operate flights from Mississippi to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated maio 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$377Average$417FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$384Average$569FlexibilityNo cancel feeOn-time69%

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