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Panama

$170+ Cheap flights from Mexico City (MEX) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/30. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — PTY
Sep 14 — Sep 211
Mon 9/14
Mon 9/21
1 adult, Economy
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Cheap flight deals from Mexico City to Panama

Cheapest flights from Mexico City to Panama
Explore the most affordable flight options available from Mexico City to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 15, 2026.

This Kiwi.com deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/89:05 am -
Nonstop3h 50m
Thu 10/153:05 pm -
Nonstop3h 55m
Deal found 8/12$345
This Kiwi.com deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/42:10 am -
Nonstop3h 41m
Mon 10/1211:53 am -
Nonstop3h 37m
Deal found 8/14$351
This Kiwi.com deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/101:20 am -
Nonstop3h 41m
Sun 10/184:12 pm -
Nonstop3h 53m
Deal found 8/14$352
This Kiwi.com deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/23:30 pm -
Nonstop3h 44m
Fri 10/910:13 pm -
Nonstop3h 47m
Deal found 8/14$353
This Trip.com deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/209:05 am -
Nonstop3h 55m
Sun 9/273:05 pm -
Nonstop3h 55m
Deal found 8/14$359
This Trip.com deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/229:05 am -
Nonstop3h 55m
Tue 9/293:05 pm -
Nonstop3h 55m
Deal found 8/13$360
This Kiwi.com deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/272:10 am -
Nonstop3h 41m
Mon 10/59:29 am -
Nonstop3h 41m
Deal found 8/14$361
This Kiwi.com deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/312:25 am -
Nonstop3h 41m
Sun 10/1111:53 am -
Nonstop3h 37m
Deal found 8/15$364
This Kiwi.com deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1012:25 am -
Nonstop3h 41m
Fri 9/1811:47 am -
Nonstop3h 43m
Deal found 8/14$365
This Kiwi.com deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/182:10 am -
Nonstop3h 41m
Sat 9/2611:47 am -
Nonstop3h 43m
Deal found 8/14$366
This Kiwi.com deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/281:20 am -
Nonstop3h 41m
Mon 9/1411:47 am -
Nonstop3h 43m
Deal found 8/13$373
This Kiwi.com deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/275:50 am -
Nonstop3h 51m
Thu 9/310:12 pm -
Nonstop3h 48m
Deal found 8/13$374

Find flight deals from Mexico City to Panama

Keep the following information in mind while searching for Mexico City to Panama flight deals. Data was last updated August 15, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$345
(Kiwi.com)

One-way from

$170
(Copa Airlines)

Popular in

July

Cheapest in

January

Average price

$374

Good round-trip deal

$412 or less

Good one-way deal

$295 or less
Provider with most accurate pricing for Mexico City Benito Juarez-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Mexico City Benito Juarez-Panama City Tocumen Intl flights.
Search Deals
From Mexico City Benito Juarez to Panama
Search Deals
One-way flight from Mexico City Benito Juarez to Panama
Search Deals
Highest demand for flights based on searches. 3% potential increase in price ($13 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($5 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in August 2026
Search Deals
Price to beat on a round-trip flight from Mexico City Benito Juarez to Panama.
Search Deals
Price to beat on a one-way flight from Mexico City Benito Juarez to Panama.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mexico City to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 15, 2026.
Use the filters below to find and compare flights from Mexico City to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Mexico CityPanama City

MEX Mexico City Benito Juarez - PTY Panama City Tocumen Intl

MEXPTY

Mexico City Benito Juarez

Wed 9/23

3:30 pm-8:14 pm

Nonstop3h 44m

Panama City Tocumen Intl

Wed 9/30

9:27 pm-12:15 am

Nonstop3h 48m

$394

Mexico CityPanama City

MEX Mexico City Benito Juarez - PTY Panama City Tocumen Intl

MEXPTY

Mexico City Benito Juarez

Fri 9/25

3:30 pm-8:14 pm

Nonstop3h 44m

Panama City Tocumen Intl

Mon 10/5

4:12 pm-7:05 pm

Nonstop3h 53m

$394

Mexico CityPanama City

MEX Mexico City Benito Juarez - PTY Panama City Tocumen Intl

MEXPTY

Mexico City Benito Juarez

Mon 10/12

5:50 am-10:41 am

Nonstop3h 51m

Panama City Tocumen Intl

Mon 10/19

4:12 pm-7:05 pm

Nonstop3h 53m

$394

Mexico CityPanama City

MEX Mexico City Benito Juarez - PTY Panama City Tocumen Intl

MEXPTY

Mexico City Benito Juarez

Thu 9/17

5:50 am-10:41 am

Nonstop3h 51m

Panama City Tocumen Intl

Thu 9/24

9:27 pm-12:15 am

Nonstop3h 48m

$394

Mexico CityPanama City

MEX Mexico City Benito Juarez - PTY Panama City Tocumen Intl

MEXPTY

Mexico City Benito Juarez

Fri 9/18

3:30 pm-8:14 pm

Nonstop3h 44m

Panama City Tocumen Intl

Fri 9/25

7:12 pm-10:05 pm

Nonstop3h 53m

$394
Quickest round-trip

Mexico CityPanama City

MEX Mexico City Benito Juarez - PTY Panama City Tocumen Intl

MEXPTY

Mexico City Benito Juarez

Sat 8/29

1:20 am-6:01 am

Nonstop3h 41m

Panama City Tocumen Intl

Sun 9/6

9:27 pm-12:15 am

Nonstop3h 48m

$401

Mexico CityPanama City

MEX Mexico City Benito Juarez - PTY Panama City Tocumen Intl

MEXPTY

Mexico City Benito Juarez

Thu 11/12

1:10 pm-5:59 pm

Nonstop3h 49m

Panama City Tocumen Intl

Thu 11/19

11:45 am-2:30 pm

Nonstop3h 45m

$404

Mexico CityPanama City

MEX Mexico City Benito Juarez - PTY Panama City Tocumen Intl

MEXPTY

Mexico City Benito Juarez

Tue 10/6

5:50 am-10:41 am

Nonstop3h 51m

Panama City Tocumen Intl

Sat 10/10

9:29 am-12:10 pm

Nonstop3h 41m

$408

Mexico CityPanama City

MEX Mexico City Benito Juarez - PTY Panama City Tocumen Intl

MEXPTY

Mexico City Benito Juarez

Thu 9/3

2:10 am-6:51 am

Nonstop3h 41m

Panama City Tocumen Intl

Sun 9/13

4:12 pm-7:05 pm

Nonstop3h 53m

$408

Mexico CityPanama City

MEX Mexico City Benito Juarez - PTY Panama City Tocumen Intl

MEXPTY

Mexico City Benito Juarez

Thu 9/3

2:10 am-6:51 am

Nonstop3h 41m

Panama City Tocumen Intl

Fri 9/11

4:12 pm-7:05 pm

Nonstop3h 53m

$408

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/14

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

Best time to book a flight from Mexico City to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Mexico City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Panama

What is the cheapest month to book a flight from Mexico City to Panama?

Currently, January is the cheapest month in which you can book a flight from Mexico City to Panama (average of $364). Flying from Mexico City to Panama in July is currently the most expensive (average of $445). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MEX to PA?

Find hourly flight availability from Mexico City to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 15, 2026.

It’s typically best to fly out from Mexico City to Panama in the evening. Doing so could potentially save you 7% on the flight price compared to flying at noon, which is usually more expensive.

Weekly flight availability from Mexico City to Panama

Explore weekly flight availability from Mexico City to Panama. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated August 15, 2026.

The most flights from MEX to PA0 are scheduled on a Friday (9 on average). You will have fewer flight options on Wednesday, which is when the least amount of flights are scheduled (4 on average).

How often are flights from Mexico City to Panama delayed?

About 4% of weekly flights between Mexico City and Panama have experienced delays in the past year, with the average delay time being 118 minutes.

What is the most punctual flight time for Mexico City to Panama flights?

Historically, flights departing at night are less likely to be delayed, whereas flights leaving in the early afternoon tend to experience delays more often.

What day of the week experiences the fewest flight delays on this route?

Friday tends to have the lowest number of delays on this route, whereas Wednesday has historically faced a higher average of delays compared to other days of the week.

Which airline has the best punctuality record on Mexico City to Panama flights?

Over the last year, Copa Airlines have had the lowest number of delays on this route, with just 4% of flights being delayed.

How far ahead should I book a flight from Mexico City to Panama?

The price you pay for your flight from Mexico City to Panama may vary depending on when you book. For the best chance of a lower fare, look to book 78 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest day to fly from Mexico City to Panama?

Use this chart to determine the cheapest time to fly round-trip from Mexico City to Panama. Price data was last updated on August 15, 2026.

Travelers seeking maximum savings on their Mexico City to Panama flight should consider departing on Thursday afternoons when fares are most often at their lowest. Tuesday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated August 15, 2026.
Peruse reviews from past customers who have flown with Copa Airlines,Aeromexico, andAvianca from Mexico City to Panama to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,558 reviews

Boarding

7.8

Entertainment

6.8

Overall

7.6

Comfort

7.4

Food

6.9

Crew

8.1

Reviews

1 / 20
2.0
Mediocre

Anonymous,Jul 2026

BOS - PTY

Airline was delayed 1 hour, that made my layover flight be missed, gave wrong information about gates, they closed the gates in my face, rebooked me, and had business class, and rebooked me not business class
Copa Airlines
7.6
Good
1,558 reviews
Copa Airlines
7.6
Good
1,558 reviews

Boarding

7.8

Entertainment

6.8

Overall

7.6

Comfort

7.4

Food

6.9

Crew

8.1

Reviews

1 / 20
2.0
Mediocre

Anonymous,Jul 2026

BOS - PTY

Airline was delayed 1 hour, that made my layover flight be missed, gave wrong information about gates, they closed the gates in my face, rebooked me, and had business class, and rebooked me not business class
Aeromexico
7.4
Good
1,469 reviews
Copa Airlines
7.6
Good
1,558 reviews

Boarding

7.8

Entertainment

6.8

Overall

7.6

Comfort

7.4

Food

6.9

Crew

8.1

Reviews

1 / 20
2.0
Mediocre

Anonymous,Jul 2026

BOS - PTY

Airline was delayed 1 hour, that made my layover flight be missed, gave wrong information about gates, they closed the gates in my face, rebooked me, and had business class, and rebooked me not business class
Avianca
6.5
Okay
2,538 reviews
Copa Airlines
7.6
Good
1,558 reviews

Boarding

7.8

Entertainment

6.8

Overall

7.6

Comfort

7.4

Food

6.9

Crew

8.1

Reviews

1 / 20
2.0
Mediocre

Anonymous,Jul 2026

BOS - PTY

Airline was delayed 1 hour, that made my layover flight be missed, gave wrong information about gates, they closed the gates in my face, rebooked me, and had business class, and rebooked me not business class

Related info for your journey

Find useful and relevant information for your journey from Mexico City to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Mexico City to Panama?

    If you book a flight to Panama from Mexico City, you will be flying from Benito Juarez, which is the city’s only airport. Mexico City Benito Juarez (MEX) is located 5.5 mi from the center of Mexico City.

  • How popular is this Mexico City to Panama flight route?

    The Mexico City Benito Juarez to Panama flight path was viewed by 10 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Mexico City to Panama?

    Copa Airlines can get you from Mexico City to Panama in just under 3h 44m. Your travel time will be generally consistent. Airlines will cover a distance of 1497 mi. All flights are typically nonstop.

  • What are the cheapest airlines to fly from Mexico City to Panama one-way?

    The cheapest airlines for a one-way flight from Mexico City to Panama are Avianca ($151), Aeromexico ($161), and Copa Airlines ($336).

  • What are the most reliable airlines from Mexico City to Panama?

    No one likes to see their flight delayed. When booking a flight from Mexico City to Panama consider choosing AeroMexico Connect (96%), Aeromexico (95%) or Copa Airlines (93%) as they are the most reliable in getting you off to your destination on time.

  • What are the cheapest flights from Mexico City to Panama?

    Looking at all options, your cheapest flight can be booked for $192. While the most popular route (Mexico City Benito Juarez - Panama City Tocumen Intl) can be booked for $374 on average, our data indicates $503 when flying from Mexico City to Panama.

  • Can I find deals for flights from Mexico City to Panama that include hotel bookings?

    Yes. In addition to deals on Mexico City to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mexico City to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Panama.

  • Can I find deals for business class flights from Mexico City to Panama?

    Yes. Cheapflights offers flight deals from Mexico City to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mexico City to Panama?

    Currently, January is the cheapest month in which you can book a flight from Mexico City to Panama (average of $364). Flying from Mexico City to Panama in July is currently the most expensive (average of $445). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top 3 airlines flying from Mexico City to Panama

Discover the top 3 airlines that operate flights from Mexico City to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 15, 2026.
AirlineCheapestAverageFlexibilityOn-time
Copa AirlinesCheapest$212Average$429FlexibilityNo cancel feeOn-time70%
AeromexicoCheapest$226Average$376FlexibilityNo cancel feeOn-timeN/A
AviancaCheapest$337Average$409FlexibilityNo cancel feeOn-time71%

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