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$150+ Cheap flights from Mexico City (MEX) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/12. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — PTY
Aug 23 — Aug 301
Sat 8/23
Sat 8/30
1 adult, Economy
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Cheap flight deals from Mexico City to Panama

Keep the following information in mind while searching for Mexico City to Panama flight deals. Data was last updated August 18, 2025.

Round-trip from

$315
(Priceline)

One-way from

$150
(Cheapflightsfares)

Popular in

October

Cheapest in

July

Average price

$386

Good round-trip deal

$333 or less

Good one-way deal

$260 or less
From Mexico City Benito Juarez to Panama
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One-way flight from Mexico City Benito Juarez to Panama
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Highest demand for flights based on searches. 9% potential increase in price ($43 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($5 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Price to beat on a round-trip flight from Mexico City Benito Juarez to Panama.
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Price to beat on a one-way flight from Mexico City Benito Juarez to Panama.
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Find flight deals from Mexico City to Panama

Cheapest flights from Mexico City to Panama
Explore the most affordable flight options available from Mexico City to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 18, 2025.

This Priceline deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/2511:15 pmMEX - PTY
1 stop13h 45mAvianca
Sat 11/298:25 pmPTY - MEX
1 stop15h 55mAvianca
Deal found 8/15$315
This Kiwi.com deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/261:05 pmMEX - PTY
Nonstop3h 44mCopa Airlines
Wed 10/110:21 pmPTY - MEX
Nonstop3h 39mCopa Airlines
Deal found 8/16$318
This Kiwi.com deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/293:30 pmMEX - PTY
Nonstop3h 44mCopa Airlines
Mon 10/69:24 amPTY - MEX
Nonstop3h 46mCopa Airlines
Deal found 8/15$319
This Kiwi.com deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/143:30 pmMEX - PTY
Nonstop3h 44mCopa Airlines
Sun 9/2110:21 pmPTY - MEX
Nonstop3h 39mCopa Airlines
Deal found 8/15$321
This Kiwi.com deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/303:30 pmMEX - PTY
Nonstop3h 44mCopa Airlines
Tue 10/79:24 amPTY - MEX
Nonstop3h 46mCopa Airlines
Deal found 8/16$322
This Kiwi.com deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/153:30 pmMEX - PTY
Nonstop3h 44mCopa Airlines
Mon 9/2210:21 pmPTY - MEX
Nonstop3h 39mCopa Airlines
Deal found 8/16$323
This Avianca deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/2812:40 amMEX - PTY
1 stop38h 50mAvianca
Mon 10/611:00 amPTY - MEX
1 stop13h 00mAvianca
Deal found 8/15$328
This Copa Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/31:05 pmMEX - PTY
Nonstop3h 45mCopa Airlines
Sat 10/119:24 amPTY - MEX
Nonstop3h 46mCopa Airlines
Deal found 8/17$329
This deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/167:40 amMEX - PTY
Nonstop3h 59mAeromexico
Wed 9/242:44 pmPTY - MEX
Nonstop3h 56mAeromexico
Deal found 8/15$330
This Avianca deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/104:20 amMEX - PTY
1 stop5h 00mAvianca
Sun 11/233:35 pmPTY - MEX
1 stop10h 40mAvianca
Deal found 8/16$331
This Cheapflightsfares deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/611:20 pmMEX - PTY
1 stop16h 10mAvianca
Tue 10/148:10 pmPTY - MEX
1 stop15h 45mAvianca
Deal found 8/17$336

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mexico City to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 18, 2025.
Use the filters below to find and compare flights from Mexico City to Panama that are best for you.

Fly from

Mexico City

Fly to

Panama

Route

Depart

Return

Price

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Tue 11/25

11:15 pm-2:00 pm

1 stop13h 45m

Panama City Tocumen Intl

Sat 11/29

8:25 pm-11:20 am

1 stop15h 55m

$315

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Fri 9/26

1:05 pm-5:49 pm

Nonstop3h 44m

Panama City Tocumen Intl

Wed 10/1

10:21 pm-1:00 am

Nonstop3h 39m

$318

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Mon 9/29

3:30 pm-8:14 pm

Nonstop3h 44m

Panama City Tocumen Intl

Mon 10/6

9:24 am-12:10 pm

Nonstop3h 46m

$319

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Fri 2/13

12:40 am-2:00 pm

1 stop12h 20m

Panama City Tocumen Intl

Sun 2/22

8:25 pm-1:15 am

1 stop5h 50m

$319

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Fri 2/6

11:15 pm-8:50 am

1 stop8h 35m

Panama City Tocumen Intl

Sun 2/15

8:25 pm-1:15 am

1 stop5h 50m

$319

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Sun 9/14

3:30 pm-8:14 pm

Nonstop3h 44m

Panama City Tocumen Intl

Sun 9/21

10:21 pm-1:00 am

Nonstop3h 39m

$321

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Tue 9/30

3:30 pm-8:14 pm

Nonstop3h 44m

Panama City Tocumen Intl

Tue 10/7

9:24 am-12:10 pm

Nonstop3h 46m

$322

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Mon 9/15

3:30 pm-8:14 pm

Nonstop3h 44m

Panama City Tocumen Intl

Mon 9/22

10:21 pm-1:00 am

Nonstop3h 39m

$323

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Wed 1/14

12:55 pm-7:25 pm

1 stop5h 30m

Panama City Tocumen Intl

Wed 1/21

2:55 am-10:55 pm

1 stop21h 00m

$325

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Wed 11/12

12:55 pm-7:25 pm

1 stop5h 30m

$150

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/15

Showing 1-10 of 14 results
1
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Best time to book a flight from Mexico City to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Mexico City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Panama

What is the cheapest month to book a flight from Mexico City to Panama?

Currently, October is the cheapest month in which you can book a flight from Mexico City to Panama (average of $478). Flying from Mexico City to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MEX to PA?

Find hourly flight availability from Mexico City to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 18, 2025.

It’s typically best to fly out from Mexico City to Panama in the evening. Doing so could potentially save you 18% on the flight price compared to flying in the morning, which is usually more expensive.

What is the cheapest day to fly from Mexico City to Panama?

Use this chart to determine the cheapest time to fly round-trip from Mexico City to Panama. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Mexico City to Panama flight should consider departing on Wednesday evenings when fares are most often at their lowest. Sunday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Mexico City to Panama

Explore weekly flight availability from Mexico City to Panama. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated August 18, 2025.

The most flights from MEX to PA0 are scheduled on a Friday (8 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (4 on average).

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated August 18, 2025.
Peruse reviews from past customers who have flown with Copa Airlines and Avianca from Mexico City to Panama to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.5
Good
1,510 reviews

Overall

7.5

Entertainment

6.8

Boarding

7.8

Crew

8.1

Comfort

7.4

Food

6.8

Reviews

1 / 20
4.0
Okay

Paul,Jun 2025

PTY - MIA

The boarding process was terrible. No one followed the group numbers. Everyone got up and stood in the tiles upon landing. People kept getting up during the meal and beverage service to go the bathrooms, the crew had to go back and forth in the isles, the service took forever.
Copa Airlines
7.5
Good
1,510 reviews
Copa Airlines
7.5
Good
1,510 reviews

Overall

7.5

Entertainment

6.8

Boarding

7.8

Crew

8.1

Comfort

7.4

Food

6.8

Reviews

1 / 20
4.0
Okay

Paul,Jun 2025

PTY - MIA

The boarding process was terrible. No one followed the group numbers. Everyone got up and stood in the tiles upon landing. People kept getting up during the meal and beverage service to go the bathrooms, the crew had to go back and forth in the isles, the service took forever.
Avianca
6.7
Okay
2,407 reviews
Copa Airlines
7.5
Good
1,510 reviews

Overall

7.5

Entertainment

6.8

Boarding

7.8

Crew

8.1

Comfort

7.4

Food

6.8

Reviews

1 / 20
4.0
Okay

Paul,Jun 2025

PTY - MIA

The boarding process was terrible. No one followed the group numbers. Everyone got up and stood in the tiles upon landing. People kept getting up during the meal and beverage service to go the bathrooms, the crew had to go back and forth in the isles, the service took forever.

Related info for your journey

Find useful and relevant information for your journey from Mexico City to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Mexico City to Panama?

    If you book a flight to Panama from Mexico City, you will be flying from Benito Juarez, which is the city’s only airport. Mexico City Benito Juarez (MEX) is located 5.5 mi from the center of Mexico City.

  • How popular is this Mexico City to Panama flight route?

    The Mexico City Benito Juarez to Panama flight path was viewed by 19 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What are the most reliable airlines from Mexico City to Panama?

    No one likes to see their flight delayed. When booking a flight from Mexico City to Panama consider choosing Emirates (98%), Copa Airlines (94%) or Aeromexico (89%) as they are the most reliable in getting you off to your destination on time.

  • What are the cheapest flights from Mexico City to Panama?

    Looking at all options, your cheapest flight can be booked for $165. While the most popular route (Mexico City Benito Juarez - Panama City Tocumen Intl) can be booked for $315 on average our data indicates $558 when flying from Mexico City to Panama.

  • Can I find deals for flights from Mexico City to Panama that include hotel bookings?

    Yes. In addition to deals on Mexico City to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mexico City to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Panama.

  • Can I find deals for business class flights from Mexico City to Panama?

    Yes. Cheapflights offers flight deals from Mexico City to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mexico City to Panama?

    Currently, October is the cheapest month in which you can book a flight from Mexico City to Panama (average of $478). Flying from Mexico City to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top 2 airlines flying from Mexico City to Panama

Discover the top 2 airlines that operate flights from Mexico City to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$343Average$473FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$378Average$474FlexibilityNo cancel feeOn-time70%

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