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$132+ Cheap flights from Mexico City (MEX) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/21. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — PTY
Dec 13 — Dec 201
Sat 12/13
Sat 12/20
1 adult, Economy
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Cheap flight deals from Mexico City to Panama

Keep the following information in mind while searching for Mexico City to Panama flight deals. Data was last updated November 13, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$287
(Cheapflightsfares)

One-way from

$132
(Cheapflightsfares)

Popular in

December

Cheapest in

July

Average price

$431

Good round-trip deal

$468 or less

Good one-way deal

$221 or less
Provider with most accurate pricing for Mexico City Benito Juarez-Panama City Tocumen Intl flight deals.
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Provider most trusted by Cheapflights users for Mexico City Benito Juarez-Panama City Tocumen Intl flights.
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From Mexico City Benito Juarez to Panama
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One-way flight from Mexico City Benito Juarez to Panama
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Highest demand for flights based on searches. 10% potential increase in price ($46 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($8 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Price to beat on a round-trip flight from Mexico City Benito Juarez to Panama.
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Price to beat on a one-way flight from Mexico City Benito Juarez to Panama.
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Find flight deals from Mexico City to Panama

Cheapest flights from Mexico City to Panama
Explore the most affordable flight options available from Mexico City to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 13, 2025.

This Cheapflightsfares deal was found by Cheapflights users on 11/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/34:00 amMEX - PTY
1 stop13h 55mAvianca
Thu 12/112:55 pmPTY - MEX
1 stop13h 05mAvianca
Deal found 11/13$290
This Cheapflightsfares deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/314:00 amMEX - PTY
1 stop13h 55mAvianca
Sun 1/117:50 pmPTY - MEX
1 stop6h 25mAvianca
Deal found 11/11$291
This Cheapflightsfares deal was found by Cheapflights users on 11/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/314:00 amMEX - PTY
1 stop5h 30mAvianca
Thu 1/157:50 pmPTY - MEX
1 stop16h 30mAvianca
Deal found 11/13$304
This Kiwi.com deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/314:00 amMEX - PTY
1 stop5h 30mAvianca
Fri 1/97:50 pmPTY - MEX
1 stop6h 25mAvianca
Deal found 11/10$307
This Copa Airlines deal was found by Cheapflights users on 11/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/311:20 amMEX - PTY
Nonstop3h 40mCopa Airlines
Thu 1/1510:13 pmPTY - MEX
Nonstop3h 47mCopa Airlines
Deal found 11/13$313
This Priceline deal was found by Cheapflights users on 11/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/284:50 pmMEX - PTY
1 stop16h 40mAvianca
Sat 12/65:50 pmPTY - MEX
1 stop10h 10mAvianca
Deal found 11/13$314
This Priceline deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/284:50 pmMEX - PTY
1 stop16h 40mAvianca
Tue 12/22:55 pmPTY - MEX
1 stop9h 00mAvianca
Deal found 11/12$325
This Copa Airlines deal was found by Cheapflights users on 11/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/271:20 amMEX - PTY
Nonstop3h 39mCopa Airlines
Sat 12/69:28 pmPTY - MEX
Nonstop3h 47mCopa Airlines
Deal found 11/13$339
This Aeromexico deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/318:55 amMEX - PTY
Nonstop3h 45mAeromexico
Sat 1/103:00 pmPTY - MEX
Nonstop4h 05mAeromexico
Deal found 11/11$348
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/41:20 amMEX - PTY
Nonstop3h 40mCopa Airlines
Sun 12/710:14 pmPTY - MEX
Nonstop3h 46mCopa Airlines
Deal found 11/11$372
This Copa Airlines deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/81:20 amMEX - PTY
Nonstop3h 40mCopa Airlines
Tue 12/1610:14 pmPTY - MEX
Nonstop3h 46mCopa Airlines
Deal found 11/12$377

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mexico City to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 13, 2025.
Use the filters below to find and compare flights from Mexico City to Panama that are best for you.

Fly from

Mexico City

Fly to

Panama

Route

Depart

Return

Price

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Fri 11/28

3:30 pm-8:14 pm

Nonstop3h 44m

Panama City Tocumen Intl

Sat 12/6

9:18 am-12:10 pm

Nonstop3h 52m

$339

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Mon 12/1

3:30 pm-8:15 pm

Nonstop3h 45m

Panama City Tocumen Intl

Mon 12/8

10:14 pm-1:00 am

Nonstop3h 46m

$377

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Wed 12/3

1:20 am-6:00 am

Nonstop3h 40m

Panama City Tocumen Intl

Thu 12/11

10:14 pm-1:00 am

Nonstop3h 46m

$377

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Thu 2/12

3:30 pm-8:07 pm

Nonstop3h 37m

Panama City Tocumen Intl

Thu 2/19

10:10 pm-1:00 am

Nonstop3h 50m

$377

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Mon 12/22

2:00 am-6:41 am

Nonstop3h 41m

Panama City Tocumen Intl

Tue 12/30

10:14 pm-1:00 am

Nonstop3h 46m

$377

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Thu 11/27

1:20 am-5:59 am

Nonstop3h 39m

Panama City Tocumen Intl

Fri 12/5

10:14 pm-1:00 am

Nonstop3h 46m

$377

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Sat 1/10

2:00 am-6:41 am

Nonstop3h 41m

Panama City Tocumen Intl

Mon 1/19

10:13 pm-1:00 am

Nonstop3h 47m

$384

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Tue 2/17

5:00 am-2:00 pm

1 stop8h 00m

$137

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Sun 12/7

4:00 am-10:30 am

1 stop5h 30m

$146

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Wed 11/19

4:50 pm-10:30 am

1 stop16h 40m

$163

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/11

Showing 1-10 of 13 results
1
2

Best time to book a flight from Mexico City to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Mexico City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Panama

What is the cheapest month to book a flight from Mexico City to Panama?

Currently, September is the cheapest month in which you can book a flight from Mexico City to Panama (average of $176). Flying from Mexico City to Panama in April is currently the most expensive (average of $378). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MEX to PA?

Find hourly flight availability from Mexico City to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 13, 2025.

It’s typically best to fly out from Mexico City to Panama in the evening. Doing so could potentially save you 8% on the flight price compared to flying in the morning, which is usually more expensive.

What is the cheapest day to fly from Mexico City to Panama?

Use this chart to determine the cheapest time to fly round-trip from Mexico City to Panama. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Mexico City to Panama flight should consider departing on Wednesday evenings when fares are most often at their lowest. Tuesday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Mexico City to Panama

Explore weekly flight availability from Mexico City to Panama. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated November 13, 2025.

The most flights from MEX to PA0 are scheduled on a Wednesday (9 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (7 on average).

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated November 13, 2025.
Peruse reviews from past customers who have flown with Copa Airlines, Aeromexico, and Avianca from Mexico City to Panama to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,565 reviews

Comfort

7.4

Entertainment

6.8

Food

6.9

Boarding

7.8

Crew

8.1

Overall

7.6

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Copa Airlines
7.6
Good
1,565 reviews
Copa Airlines
7.6
Good
1,565 reviews

Comfort

7.4

Entertainment

6.8

Food

6.9

Boarding

7.8

Crew

8.1

Overall

7.6

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Aeromexico
7.4
Good
1,668 reviews
Copa Airlines
7.6
Good
1,565 reviews

Comfort

7.4

Entertainment

6.8

Food

6.9

Boarding

7.8

Crew

8.1

Overall

7.6

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Avianca
6.6
Okay
2,475 reviews
Copa Airlines
7.6
Good
1,565 reviews

Comfort

7.4

Entertainment

6.8

Food

6.9

Boarding

7.8

Crew

8.1

Overall

7.6

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip

Related info for your journey

Find useful and relevant information for your journey from Mexico City to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Mexico City to Panama?

    If you book a flight to Panama from Mexico City, you will be flying from Benito Juarez, which is the city’s only airport. Mexico City Benito Juarez (MEX) is located 5.5 mi from the center of Mexico City.

  • How popular is this Mexico City to Panama flight route?

    The Mexico City Benito Juarez to Panama flight path was viewed by 20 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Mexico City to Panama?

    Copa Airlines can get you from Mexico City to Panama in just under 3h 44m. Your travel time will be generally consistent. Airlines will cover a distance of 1497 mi. All flights are typically nonstop.

  • What are the most reliable airlines from Mexico City to Panama?

    No one likes to see their flight delayed. When booking a flight from Mexico City to Panama consider choosing Aeromexico (92%), Copa Airlines (92%) or Emirates (91%) as they are the most reliable in getting you off to your destination on time.

  • What are the cheapest flights from Mexico City to Panama?

    Looking at all options, your cheapest flight can be booked for $190. While the most popular route (Mexico City Benito Juarez - Panama City Tocumen Intl) can be booked for $298 on average, our data indicates $754 when flying from Mexico City to Panama.

  • Can I find deals for flights from Mexico City to Panama that include hotel bookings?

    Yes. In addition to deals on Mexico City to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mexico City to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Panama.

  • Can I find deals for business class flights from Mexico City to Panama?

    Yes. Cheapflights offers flight deals from Mexico City to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mexico City to Panama?

    Currently, September is the cheapest month in which you can book a flight from Mexico City to Panama (average of $176). Flying from Mexico City to Panama in April is currently the most expensive (average of $378). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top 3 airlines flying from Mexico City to Panama

Discover the top 3 airlines that operate flights from Mexico City to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 13, 2025.
AirlineCheapestAverageFlexibilityOn-time
AeromexicoCheapest$304Average$343FlexibilityNo cancel feeOn-timeN/A
Copa AirlinesCheapest$329Average$439FlexibilityNo cancel feeOn-time70%
AviancaCheapest$337Average$521FlexibilityNo cancel feeOn-time71%

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