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$177+ Cheap flights from Mexico City (MEX) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/27. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — PTY
May 6 — May 131
Tue 5/6
Tue 5/13
1 adult, Economy
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Cheap flight deals from Mexico City to Panama

Keep the following information in mind while searching for Mexico City to Panama flight deals. Data was last updated May 1, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$363
(Priceline)

One-way from

$177
(Cheapflightsfares)

Popular in

July

Cheapest in

February

Average price

$453

Good round-trip deal

$381 or less

Good one-way deal

$247 or less
Provider with most accurate pricing for Mexico City Benito Juarez-Panama City Tocumen Intl flight deals.
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Provider most trusted by Cheapflights users for Mexico City Benito Juarez-Panama City Tocumen Intl flights.
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From Mexico City Benito Juarez to Panama
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One-way flight from Mexico City Benito Juarez to Panama
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Highest demand for flights based on searches. 9% potential increase in price ($47 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).
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Average for round-trip flights in May 2025
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Price to beat on a round-trip flight from Mexico City Benito Juarez to Panama.
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Price to beat on a one-way flight from Mexico City Benito Juarez to Panama.
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Find flight deals from Mexico City to Panama

Cheapest flights from Mexico City to Panama
Explore the most affordable flight options available from Mexico City to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

This Priceline deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/3112:40 amMEX - PTY
1 stop8h 30mAvianca
Sun 11/3011:25 amPTY - MEX
1 stop12h 30mAvianca
Deal found 4/30$363
This Copa Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/192:00 amMEX - PTY
Nonstop3h 44mCopa Airlines
Fri 10/249:21 pmPTY - MEX
Nonstop3h 54mCopa Airlines
Deal found 4/30$379
This Mytrip deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/14:50 pmMEX - PTY
1 stop16h 35mMultiple Airlines
Mon 5/123:25 amPTY - MEX
1 stop8h 45mMultiple Airlines
Deal found 4/29$519
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/1012:50 pmMEX - PTY
1 stop14h 15mUnited Airlines
Tue 5/1310:55 pmPTY - MEX
2 stops15h 20mUnited Airlines
Deal found 4/29$1,106

Cheapflights Fare Finder

Customize your flight search to find flights from Mexico City to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
Use the filters below to find and compare flights from Mexico City to Panama that are best for you.

Fly from

Mexico City

Fly to

Panama

Route

Depart

Return

Price

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Thu 7/31

12:40 am-10:10 am

1 stop8h 30m

Panama City Tocumen Intl

Sun 11/30

11:25 am-10:55 pm

1 stop12h 30m

$363

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Sat 7/19

5:50 am-10:34 am

Nonstop3h 44m

Panama City Tocumen Intl

Wed 10/29

7:03 pm-10:05 pm

Nonstop4h 02m

$379

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Tue 6/10

5:00 am-2:40 pm

1 stop8h 40m

Panama City Tocumen Intl

Thu 7/31

9:30 pm-12:15 am

Nonstop3h 45m

$960

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Sat 5/10

12:50 pm-4:05 am

1 stop14h 15m

Panama City Tocumen Intl

Tue 5/13

10:55 pm-1:15 pm

2 stops15h 20m

$1,106

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Tue 5/27

12:55 pm-12:10 am

2 stops10h 15m

$177

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Mon 5/26

1:40 am-6:18 am

Nonstop3h 38m

$429

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Tue 5/27

5:00 am-12:19 pm

2 stops30h 19m

$767

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Mon 5/26

12:15 am-7:31 pm

2 stops18h 16m

$1,186

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/30

Best time to book a flight from Mexico City to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Mexico City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Panama

What is the cheapest month to book a flight from Mexico City to Panama?

Currently, October is the cheapest month in which you can book a flight from Mexico City to Panama (average of $478). Flying from Mexico City to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MEX to PA?

Find hourly flight availability from Mexico City to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 1, 2025.

It’s typically best to fly out from Mexico City to Panama in the evening. Doing so could potentially save you 14% on the flight price compared to flying in the afternoon, which is usually more expensive.

What is the cheapest day to fly from Mexico City to Panama?

Use this chart to determine the cheapest time to fly round-trip from Mexico City to Panama. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Mexico City to Panama flight should consider departing on Wednesday evenings when fares are most often at their lowest. Sunday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Mexico City to Panama

Explore weekly flight availability from Mexico City to Panama. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated May 1, 2025.

The most flights from MEX to PA0 are scheduled on a Monday (9 on average). You will have fewer flight options on Saturday, which is when the least amount of flights are scheduled (6 on average).

Rainfall in Panama by month

Plan your trip to Panama by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Panama ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama when rainfall is around 0.4 in.

Temperature in Panama by month

Plan your trip to Panama by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Panama, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated May 1, 2025.
Copa Airlines
7.5
Good
1,415 reviews

Food

6.8

Boarding

7.8

Crew

8.1

Entertainment

6.8

Comfort

7.4

Overall

7.5

Reviews

1 / 20
8.0
Excellent

Anonymous,Mar 2025

LIM - PTY

you go security buy an expensive bottle of water to take on the plane and then you have to go to another security point where they confiscate your water, the planes left on time and arrived on time. excellent food was mostly tasteless and overheated, no entertainment. wifi was glitchy.
Copa Airlines
7.5
Good
1,415 reviews
Copa Airlines
7.5
Good
1,415 reviews

Food

6.8

Boarding

7.8

Crew

8.1

Entertainment

6.8

Comfort

7.4

Overall

7.5

Reviews

1 / 20
8.0
Excellent

Anonymous,Mar 2025

LIM - PTY

you go security buy an expensive bottle of water to take on the plane and then you have to go to another security point where they confiscate your water, the planes left on time and arrived on time. excellent food was mostly tasteless and overheated, no entertainment. wifi was glitchy.
United Airlines
7.4
Good
8,696 reviews
Copa Airlines
7.5
Good
1,415 reviews

Food

6.8

Boarding

7.8

Crew

8.1

Entertainment

6.8

Comfort

7.4

Overall

7.5

Reviews

1 / 20
8.0
Excellent

Anonymous,Mar 2025

LIM - PTY

you go security buy an expensive bottle of water to take on the plane and then you have to go to another security point where they confiscate your water, the planes left on time and arrived on time. excellent food was mostly tasteless and overheated, no entertainment. wifi was glitchy.
American Airlines
7.2
Good
10,000 reviews
Copa Airlines
7.5
Good
1,415 reviews

Food

6.8

Boarding

7.8

Crew

8.1

Entertainment

6.8

Comfort

7.4

Overall

7.5

Reviews

1 / 20
8.0
Excellent

Anonymous,Mar 2025

LIM - PTY

you go security buy an expensive bottle of water to take on the plane and then you have to go to another security point where they confiscate your water, the planes left on time and arrived on time. excellent food was mostly tasteless and overheated, no entertainment. wifi was glitchy.
Avianca
6.7
Okay
2,317 reviews
Copa Airlines
7.5
Good
1,415 reviews

Food

6.8

Boarding

7.8

Crew

8.1

Entertainment

6.8

Comfort

7.4

Overall

7.5

Reviews

1 / 20
8.0
Excellent

Anonymous,Mar 2025

LIM - PTY

you go security buy an expensive bottle of water to take on the plane and then you have to go to another security point where they confiscate your water, the planes left on time and arrived on time. excellent food was mostly tasteless and overheated, no entertainment. wifi was glitchy.

Related info for your journey

Find useful and relevant information for your journey from Mexico City to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Mexico City to Panama?

    If you book a flight to Panama from Mexico City, you will be flying from Benito Juarez, which is the city’s only airport. Mexico City Benito Juarez (MEX) is located 5.5 mi from the center of Mexico City.

  • How popular is this Mexico City to Panama flight route?

    The Mexico City Benito Juarez to Panama flight path was viewed by 15 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What are the cheapest airlines to fly from Mexico City to Panama one-way?

    The cheapest airlines for a one-way flight from Mexico City to Panama are Avianca ($177), Copa Airlines ($429), and American Airlines ($767).

  • What are the cheapest flights from Mexico City to Panama?

    Looking at all options, your cheapest flight can be booked for $171. While the most popular route (Mexico City Benito Juarez - Panama City Tocumen Intl) can be booked for $324 on average our data indicates $449 when flying from Mexico City to Panama.

  • Can I find deals for flights from Mexico City to Panama that include hotel bookings?

    Yes. In addition to deals on Mexico City to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mexico City to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Panama.

  • Can I find deals for business class flights from Mexico City to Panama?

    Yes. Cheapflights offers flight deals from Mexico City to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mexico City to Panama?

    Currently, October is the cheapest month in which you can book a flight from Mexico City to Panama (average of $478). Flying from Mexico City to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top 2 airlines flying from Mexico City to Panama

Discover the top 2 airlines that operate flights from Mexico City to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$348Average$475FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$392Average$520FlexibilityNo cancel feeOn-time70%

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