HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Panama

$145+ Cheap flights from Mexico City (MEX) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/24. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — PTY
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Mexico City to Panama with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Mexico City to Panama

Keep the following information in mind while searching for Mexico City to Panama flight deals. Data was last updated September 17, 2025.

Round-trip from

$323
(Kiwi.com)

One-way from

$145
(Avianca)

Popular in

December

Cheapest in

July

Average price

$432

Good round-trip deal

$330 or less

Good one-way deal

$240 or less
From Mexico City Benito Juarez to Panama
Search Deals
One-way flight from Mexico City Benito Juarez to Panama
Search Deals
Highest demand for flights based on searches. 7% potential increase in price ($32 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in September 2025
Search Deals
Price to beat on a round-trip flight from Mexico City Benito Juarez to Panama.
Search Deals
Price to beat on a one-way flight from Mexico City Benito Juarez to Panama.
Search Deals

Find flight deals from Mexico City to Panama

Cheapest flights from Mexico City to Panama
Explore the most affordable flight options available from Mexico City to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This Kiwi.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/63:30 pmMEX - PTY
Nonstop3h 43mCopa Airlines
Sat 10/1110:21 pmPTY - MEX
Nonstop3h 39mCopa Airlines
Deal found 9/17$323
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/261:05 pmMEX - PTY
Nonstop3h 44mCopa Airlines
Mon 9/2911:46 amPTY - MEX
Nonstop3h 44mCopa Airlines
Deal found 9/15$324
This Cheapflightsfares deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3111:15 pmMEX - PTY
1 stop13h 45mAvianca
Wed 11/53:35 pmPTY - MEX
1 stop10h 40mAvianca
Deal found 9/15$326
This Copa Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/33:30 pmMEX - PTY
Nonstop3h 43mCopa Airlines
Sun 10/1210:21 pmPTY - MEX
Nonstop3h 39mCopa Airlines
Deal found 9/17$329
This Aeromexico deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/318:40 amMEX - PTY
Nonstop3h 52mAeromexico
Wed 11/52:44 pmPTY - MEX
Nonstop4h 01mAeromexico
Deal found 9/16$330
This Aeromexico deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/268:40 amMEX - PTY
Nonstop3h 52mAeromexico
Tue 12/162:36 pmPTY - MEX
Nonstop3h 59mAeromexico
Deal found 9/17$343
This Copa Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/201:05 pmMEX - PTY
Nonstop3h 44mCopa Airlines
Sat 10/49:26 amPTY - MEX
Nonstop3h 44mCopa Airlines
Deal found 9/16$355
This Aeromexico deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/128:40 amMEX - PTY
Nonstop3h 52mAeromexico
Wed 1/73:02 pmPTY - MEX
Nonstop3h 38mAeromexico
Deal found 9/16$356
This Priceline deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2912:40 amMEX - PTY
1 stop12h 20mAvianca
Thu 11/69:45 amPTY - MEX
1 stop14h 10mAvianca
Deal found 9/15$362
This Priceline deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2212:40 amMEX - PTY
1 stop14h 50mAvianca
Sun 10/267:50 pmPTY - MEX
1 stop6h 25mAvianca
Deal found 9/16$364
This Aeromexico deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/308:40 amMEX - PTY
Nonstop3h 52mAeromexico
Sat 11/82:36 pmPTY - MEX
Nonstop3h 59mAeromexico
Deal found 9/16$369

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mexico City to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Mexico City to Panama that are best for you.

Fly from

Mexico City

Fly to

Panama

Route

Depart

Return

Price

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Fri 10/31

1:10 pm-5:55 pm

Nonstop3h 45m

Panama City Tocumen Intl

Wed 11/5

10:03 pm-1:00 am

Nonstop3h 57m

$329

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Fri 10/3

3:30 pm-8:13 pm

Nonstop3h 43m

Panama City Tocumen Intl

Sun 10/12

10:21 pm-1:00 am

Nonstop3h 39m

$329

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Fri 10/3

9:50 am-2:39 pm

Nonstop3h 49m

Panama City Tocumen Intl

Tue 10/7

11:50 am-2:30 pm

Nonstop3h 40m

$329

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Thu 10/9

9:50 am-2:39 pm

Nonstop3h 49m

Panama City Tocumen Intl

Sun 10/12

10:21 pm-1:00 am

Nonstop3h 39m

$329

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Fri 10/3

3:30 pm-8:13 pm

Nonstop3h 43m

Panama City Tocumen Intl

Wed 10/8

9:26 am-12:10 pm

Nonstop3h 44m

$329

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Sat 9/27

3:30 pm-8:14 pm

Nonstop3h 44m

Panama City Tocumen Intl

Sat 10/4

9:26 am-12:10 pm

Nonstop3h 44m

$329

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Mon 10/6

9:50 am-2:39 pm

Nonstop3h 49m

Panama City Tocumen Intl

Mon 10/13

9:26 am-12:10 pm

Nonstop3h 44m

$329

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Tue 1/27

9:25 am-2:06 pm

Nonstop3h 41m

Panama City Tocumen Intl

Tue 2/3

7:02 pm-10:05 pm

Nonstop4h 03m

$355

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Sun 2/1

5:55 am-10:35 am

Nonstop3h 40m

Panama City Tocumen Intl

Sun 2/15

4:17 pm-7:20 pm

Nonstop4h 03m

$355

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Mon 10/6

1:40 am-6:20 am

Nonstop3h 40m

Panama City Tocumen Intl

Tue 10/14

9:26 am-12:10 pm

Nonstop3h 44m

$358

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Showing 1-10 of 18 results
1
2

Best time to book a flight from Mexico City to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Mexico City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Panama

What is the cheapest month to book a flight from Mexico City to Panama?

Currently, October is the cheapest month in which you can book a flight from Mexico City to Panama (average of $478). Flying from Mexico City to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MEX to PA?

Find hourly flight availability from Mexico City to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 17, 2025.

It’s typically best to fly out from Mexico City to Panama in the evening. Doing so could potentially save you 17% on the flight price compared to flying in the afternoon, which is usually more expensive.

What is the cheapest day to fly from Mexico City to Panama?

Use this chart to determine the cheapest time to fly round-trip from Mexico City to Panama. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Mexico City to Panama flight should consider departing on Wednesday evenings when fares are most often at their lowest. Sunday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Mexico City to Panama

Explore weekly flight availability from Mexico City to Panama. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated September 17, 2025.

The most flights from MEX to PA0 are scheduled on a Monday (9 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (6 on average).

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated September 17, 2025.
Peruse reviews from past customers who have flown with Copa Airlines, Aeromexico, and Avianca from Mexico City to Panama to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,533 reviews

Crew

8.1

Comfort

7.4

Entertainment

6.8

Overall

7.6

Food

6.8

Boarding

7.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Copa Airlines
7.6
Good
1,533 reviews
Copa Airlines
7.6
Good
1,533 reviews

Crew

8.1

Comfort

7.4

Entertainment

6.8

Overall

7.6

Food

6.8

Boarding

7.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Aeromexico
7.5
Good
1,696 reviews
Copa Airlines
7.6
Good
1,533 reviews

Crew

8.1

Comfort

7.4

Entertainment

6.8

Overall

7.6

Food

6.8

Boarding

7.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Avianca
6.7
Okay
2,436 reviews
Copa Airlines
7.6
Good
1,533 reviews

Crew

8.1

Comfort

7.4

Entertainment

6.8

Overall

7.6

Food

6.8

Boarding

7.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip

Related info for your journey

Find useful and relevant information for your journey from Mexico City to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Mexico City to Panama?

    If you book a flight to Panama from Mexico City, you will be flying from Benito Juarez, which is the city’s only airport. Mexico City Benito Juarez (MEX) is located 5.5 mi from the center of Mexico City.

  • How popular is this Mexico City to Panama flight route?

    The Mexico City Benito Juarez to Panama flight path was viewed by 22 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Mexico City to Panama?

    Copa Airlines can get you from Mexico City to Panama in just under 3h 45m. Your travel time will be generally consistent. Airlines will cover a distance of 1497 mi. All flights are typically nonstop.

  • What are the most reliable airlines from Mexico City to Panama?

    No one likes to see their flight delayed. When booking a flight from Mexico City to Panama consider choosing AeroMexico Connect (100%), Emirates (95%) or Aeromexico (89%) as they are the most reliable in getting you off to your destination on time.

  • What are the cheapest flights from Mexico City to Panama?

    Looking at all options, your cheapest flight can be booked for $160. While the most popular route (Mexico City Benito Juarez - Panama City Tocumen Intl) can be booked for $324 on average, our data indicates $773 when flying from Mexico City to Panama.

  • Can I find deals for flights from Mexico City to Panama that include hotel bookings?

    Yes. In addition to deals on Mexico City to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mexico City to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Panama.

  • Can I find deals for business class flights from Mexico City to Panama?

    Yes. Cheapflights offers flight deals from Mexico City to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mexico City to Panama?

    Currently, October is the cheapest month in which you can book a flight from Mexico City to Panama (average of $478). Flying from Mexico City to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top 3 airlines flying from Mexico City to Panama

Discover the top 3 airlines that operate flights from Mexico City to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
AeromexicoCheapest$303Average$329FlexibilityNo cancel feeOn-timeN/A
AviancaCheapest$343Average$521FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$354Average$441FlexibilityNo cancel feeOn-time70%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.