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$160+ Cheap flights from Mexico City (MEX) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/25. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — PTY
Mar 5 — Mar 121
Thu 3/5
Thu 3/12
1 adult, Economy
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Cheap flight deals from Mexico City to Panama

Cheapest flights from Mexico City to Panama
Explore the most affordable flight options available from Mexico City to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 3, 2026.

This Avianca deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/2712:40 am
MEX
-
PTY
1 stop12h 20m
Avianca
Sat 3/75:50 pm
PTY
-
MEX
1 stop10h 10m
Avianca
Deal found 1/31$319
This Avianca deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/114:00 am
MEX
-
PTY
1 stop5h 30m
Avianca
Thu 2/192:55 pm
PTY
-
MEX
1 stop9h 00m
Avianca
Deal found 1/31$320
This Trip.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/115:00 am
MEX
-
PTY
1 stop10h 55m
Avianca
Wed 2/252:55 pm
PTY
-
MEX
1 stop9h 00m
Avianca
Deal found 2/3$346
This Avianca deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/511:10 pm
MEX
-
PTY
1 stop8h 40m
Avianca
Fri 2/62:55 pm
PTY
-
MEX
1 stop9h 00m
Avianca
Deal found 2/2$349
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/43:30 pm
MEX
-
PTY
Nonstop3h 43m
Copa Airlines
Wed 3/1111:41 am
PTY
-
MEX
Nonstop3h 49m
Copa Airlines
Deal found 2/2$356
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/282:00 am
MEX
-
PTY
Nonstop3h 40m
Copa Airlines
Fri 3/209:22 am
PTY
-
MEX
Nonstop3h 48m
Copa Airlines
Deal found 2/1$357
This Kiwi.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/159:50 am
MEX
-
PTY
Nonstop3h 40m
Copa Airlines
Wed 4/2211:44 am
PTY
-
MEX
Nonstop3h 46m
Copa Airlines
Deal found 1/31$358
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/103:30 pm
MEX
-
PTY
Nonstop3h 40m
Copa Airlines
Mon 4/209:19 am
PTY
-
MEX
Nonstop3h 51m
Copa Airlines
Deal found 2/3$359
This Copa Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/125:55 am
MEX
-
PTY
Nonstop3h 40m
Copa Airlines
Thu 2/194:17 pm
PTY
-
MEX
Nonstop4h 03m
Copa Airlines
Deal found 1/31$364
This Copa Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/151:10 pm
MEX
-
PTY
Nonstop3h 40m
Copa Airlines
Mon 4/279:19 am
PTY
-
MEX
Nonstop3h 51m
Copa Airlines
Deal found 2/3$366

Find flight deals from Mexico City to Panama

Keep the following information in mind while searching for Mexico City to Panama flight deals. Data was last updated February 3, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$319
(Avianca)

One-way from

$157
(FlightHub)

Popular in

April

Cheapest in

July

Average price

$397

Good round-trip deal

$347 or less

Good one-way deal

$243 or less
Provider with most accurate pricing for Mexico City Benito Juarez-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Mexico City Benito Juarez-Panama City Tocumen Intl flights.
Search Deals
From Mexico City Benito Juarez to Panama
Search Deals
One-way flight from Mexico City Benito Juarez to Panama
Search Deals
Highest demand for flights based on searches. 7% potential increase in price ($30 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($4 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals
Price to beat on a round-trip flight from Mexico City Benito Juarez to Panama.
Search Deals
Price to beat on a one-way flight from Mexico City Benito Juarez to Panama.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mexico City to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 3, 2026.
Use the filters below to find and compare flights from Mexico City to Panama that are best for you.

Fly from

Mexico City

Fly to

Panama

Route

Depart

Return

Price

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Mon 3/16

11:10 pm-2:00 pm

1 stop13h 50m

Panama City Tocumen Intl

Sat 3/21

5:50 pm-3:00 am

1 stop10h 10m

$319

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Sun 5/3

11:20 pm-2:15 pm

1 stop13h 55m

Panama City Tocumen Intl

Sun 5/10

3:10 pm-11:00 pm

1 stop8h 50m

$326

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Thu 5/7

12:40 am-2:15 pm

1 stop12h 35m

Panama City Tocumen Intl

Sun 5/17

3:10 pm-11:00 pm

1 stop8h 50m

$326

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Mon 4/20

12:40 am-5:00 pm

1 stop15h 20m

Panama City Tocumen Intl

Fri 4/24

5:55 pm-3:05 am

1 stop10h 10m

$326

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Fri 4/10

4:55 am-2:15 pm

1 stop8h 20m

Panama City Tocumen Intl

Mon 4/20

5:30 am-10:55 am

1 stop6h 25m

$351

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Thu 4/16

4:55 am-2:15 pm

1 stop8h 20m

Panama City Tocumen Intl

Sun 4/26

5:30 am-10:55 am

1 stop6h 25m

$351

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Sat 5/2

1:10 pm-5:50 pm

Nonstop3h 40m

Panama City Tocumen Intl

Sun 5/10

9:22 am-12:10 pm

Nonstop3h 48m

$364

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Thu 2/26

1:10 pm-5:48 pm

Nonstop3h 38m

Panama City Tocumen Intl

Sun 3/8

9:22 am-12:10 pm

Nonstop3h 48m

$364

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Wed 2/25

1:10 pm-5:48 pm

Nonstop3h 38m

Panama City Tocumen Intl

Wed 3/4

9:22 am-12:10 pm

Nonstop3h 48m

$366

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Mon 5/4

9:50 am-2:30 pm

Nonstop3h 40m

Panama City Tocumen Intl

Thu 5/14

9:22 am-12:10 pm

Nonstop3h 48m

$366

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/2

Showing 1-10 of 22 results
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Best time to book a flight from Mexico City to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Mexico City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Panama

What is the cheapest month to book a flight from Mexico City to Panama?

Currently, November is the cheapest month in which you can book a flight from Mexico City to Panama (average of $175). Flying from Mexico City to Panama in April is currently the most expensive (average of $310). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MEX to PA?

Find hourly flight availability from Mexico City to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 3, 2026.

It’s typically best to fly out from Mexico City to Panama in the evening. Doing so could potentially save you 23% on the flight price compared to flying at noon, which is usually more expensive.

What is the cheapest day to fly from Mexico City to Panama?

Use this chart to determine the cheapest time to fly round-trip from Mexico City to Panama. Price data was last updated on January 31, 2026.

Travelers seeking maximum savings on their Mexico City to Panama flight should consider departing on Wednesday evenings when fares are most often at their lowest. Sunday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Mexico City to Panama

Explore weekly flight availability from Mexico City to Panama. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated February 3, 2026.

The most flights from MEX to PA0 are scheduled on a Monday (8 on average). You will have fewer flight options on Thursday, which is when the least amount of flights are scheduled (7 on average).

How often are flights from Mexico City to Panama delayed?

About 3% of weekly flights between Mexico City and Panama have experienced delays in the past year, with the average delay time being 138 minutes.

What is the most punctual flight time for Mexico City to Panama flights?

Historically, flights departing at night are less likely to be delayed, whereas flights leaving in the early afternoon tend to experience delays more often.

What day of the week experiences the fewest flight delays on this route?

Saturday tends to have the lowest number of delays on this route, whereas Wednesday has historically faced a higher average of delays compared to other days of the week.

Which airline has the best punctuality record on Mexico City to Panama flights?

Over the last year, Copa Airlines have had the lowest number of delays on this route, with just 3% of flights being delayed.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated February 3, 2026.
Peruse reviews from past customers who have flown with Copa Airlines, Aeromexico, and Avianca from Mexico City to Panama to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,558 reviews

Comfort

7.4

Boarding

7.8

Food

6.8

Crew

8.1

Overall

7.6

Entertainment

6.8

Reviews

1 / 20
2.0
Mediocre

Juan,Dec 2025

EZE - PTY

The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.
Copa Airlines
7.6
Good
1,558 reviews
Copa Airlines
7.6
Good
1,558 reviews

Comfort

7.4

Boarding

7.8

Food

6.8

Crew

8.1

Overall

7.6

Entertainment

6.8

Reviews

1 / 20
2.0
Mediocre

Juan,Dec 2025

EZE - PTY

The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.
Aeromexico
7.4
Good
1,583 reviews
Copa Airlines
7.6
Good
1,558 reviews

Comfort

7.4

Boarding

7.8

Food

6.8

Crew

8.1

Overall

7.6

Entertainment

6.8

Reviews

1 / 20
2.0
Mediocre

Juan,Dec 2025

EZE - PTY

The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.
Avianca
6.5
Okay
2,498 reviews
Copa Airlines
7.6
Good
1,558 reviews

Comfort

7.4

Boarding

7.8

Food

6.8

Crew

8.1

Overall

7.6

Entertainment

6.8

Reviews

1 / 20
2.0
Mediocre

Juan,Dec 2025

EZE - PTY

The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.

Related info for your journey

Find useful and relevant information for your journey from Mexico City to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Mexico City to Panama?

    If you book a flight to Panama from Mexico City, you will be flying from Benito Juarez, which is the city’s only airport. Mexico City Benito Juarez (MEX) is located 5.5 mi from the center of Mexico City.

  • How popular is this Mexico City to Panama flight route?

    The Mexico City Benito Juarez to Panama flight path was viewed by 15 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Mexico City to Panama?

    Avianca and Copa Airlines can get you from Mexico City to Panama in just under 3h 38m. Your travel time can differ by up to 10h 17m. Airlines will cover a distance of 1497 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Mexico City to Panama one-way?

    The cheapest airlines for a one-way flight from Mexico City to Panama are Avianca ($143), Aeromexico ($168), and Copa Airlines ($334).

  • What are the most reliable airlines from Mexico City to Panama?

    No one likes to see their flight delayed. When booking a flight from Mexico City to Panama consider choosing Copa Airlines (91%), Emirates (89%) or AeroMexico Connect (86%) as they are the most reliable in getting you off to your destination on time.

  • What are the cheapest flights from Mexico City to Panama?

    Looking at all options, your cheapest flight can be booked for $164. While the most popular route (Mexico City Benito Juarez - Panama City Tocumen Intl) can be booked for $358 on average, our data indicates $487 when flying from Mexico City to Panama.

  • Can I find deals for flights from Mexico City to Panama that include hotel bookings?

    Yes. In addition to deals on Mexico City to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mexico City to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Panama.

  • Can I find deals for business class flights from Mexico City to Panama?

    Yes. Cheapflights offers flight deals from Mexico City to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mexico City to Panama?

    Currently, November is the cheapest month in which you can book a flight from Mexico City to Panama (average of $175). Flying from Mexico City to Panama in April is currently the most expensive (average of $310). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from Mexico City to Panama

Discover the top 3 airlines that operate flights from Mexico City to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 3, 2026.
AirlineCheapestAverageFlexibilityOn-time
AeromexicoCheapest$225Average$363FlexibilityNo cancel feeOn-timeN/A
Copa AirlinesCheapest$328Average$419FlexibilityNo cancel feeOn-time70%
AviancaCheapest$337Average$446FlexibilityNo cancel feeOn-time71%

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