$199+ Cheap flights from Mexico City (MEX) to Panama
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/28. Fares are subject to change and may not be available on all flights or dates of travel.
Find cheap flights from Mexico City to Panama with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Mexico City to Panama
Keep the following information in mind while searching for Mexico City to Panama flight deals. Data was last updated January 20, 2026.
Most accurate provider | eDreams 3 stars |
|---|---|
Most trusted provider | eDreams 3 stars |
Round-trip from | $315 (Gotogate) |
One-way from | $199 (Kiwi.com) |
Popular in | April |
Cheapest in | July |
Average price | $403 |
Good round-trip deal | $355 or less |
Good one-way deal | $235 or less |
Find flight deals from Mexico City to Panama
Cheapest flights from Mexico City to PanamaExplore the most affordable flight options available from Mexico City to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 20, 2026.
Explore the most affordable flight options available from Mexico City to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 20, 2026.
This Super.com deal was found by Cheapflights users on 1/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Super.com deal was found by Cheapflights users on 1/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Gotogate deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Gotogate deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Gotogate deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Priceline deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Priceline deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Avianca deal was found by Cheapflights users on 1/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Priceline deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Priceline deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Kiwi.com deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Cheapflights Fare Finder
Use the filters below to find and compare flights from Mexico City to Panama that are best for you.
Fly from
Fly to
Route
Depart
Return
Price
Mexico CityPanama City
MEX - PTY
MEXPTY
Mexico City Benito Juarez
Wed 2/4
5:00 am-4:55 pm
1 stop10h 55m
Panama City Tocumen Intl
Sun 2/8
5:50 pm-3:00 am
1 stop10h 10m
Mexico CityPanama City
MEX - PTY
MEXPTY
Mexico City Benito Juarez
Fri 2/13
5:00 am-4:55 pm
1 stop10h 55m
Panama City Tocumen Intl
Fri 2/20
2:55 pm-3:00 am
1 stop13h 05m
Mexico CityPanama City
MEX - PTY
MEXPTY
Mexico City Benito Juarez
Mon 3/9
11:10 pm-8:50 am
1 stop8h 40m
Panama City Tocumen Intl
Wed 3/11
9:45 am-10:55 pm
1 stop14h 10m
Mexico CityPanama City
MEX - PTY
MEXPTY
Mexico City Benito Juarez
Sat 2/21
5:00 am-4:55 pm
1 stop10h 55m
Panama City Tocumen Intl
Sat 2/28
9:45 am-10:55 pm
1 stop14h 10m
Mexico CityPanama City
MEX - PTY
MEXPTY
Mexico City Benito Juarez
Wed 4/15
12:40 am-8:55 am
1 stop7h 15m
Panama City Tocumen Intl
Sun 4/26
11:05 am-11:00 pm
1 stop12h 55m
Mexico CityPanama City
MEX - PTY
MEXPTY
Mexico City Benito Juarez
Wed 3/11
9:25 am-2:04 pm
Nonstop3h 39m
Panama City Tocumen Intl
Wed 3/18
11:41 am-2:30 pm
Nonstop3h 49m
Mexico CityPanama City
MEX - PTY
MEXPTY
Mexico City Benito Juarez
Tue 2/24
1:20 am-6:00 am
Nonstop3h 40m
Panama City Tocumen Intl
Wed 3/4
11:41 am-2:30 pm
Nonstop3h 49m
Mexico CityPanama City
MEX - PTY
MEXPTY
Mexico City Benito Juarez
Sat 2/21
2:00 am-6:41 am
Nonstop3h 41m
Panama City Tocumen Intl
Sun 3/1
4:23 pm-7:20 pm
Nonstop3h 57m
Mexico CityPanama City
MEX - PTY
MEXPTY
Mexico City Benito Juarez
Tue 4/14
9:50 am-2:30 pm
Nonstop3h 40m
Panama City Tocumen Intl
Sat 4/25
9:19 am-12:10 pm
Nonstop3h 51m
Mexico CityPanama City
MEX - PTY
MEXPTY
Mexico City Benito Juarez
Wed 1/28
5:35 am-12:40 am
2 stops18h 05m
Best time to book a flight from Mexico City to Panama
Have a flexible travel schedule? Discover the best time to fly to Panama from Mexico City with our price prediction graph.
Cheapflights Insights
Everything you need to know about your flight from Mexico City to Panama
What is the cheapest month to book a flight from Mexico City to Panama?
Currently, September is the cheapest month in which you can book a flight from Mexico City to Panama (average of $175). Flying from Mexico City to Panama in April is currently the most expensive (average of $312). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from MEX to PA?
Find hourly flight availability from Mexico City to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 20, 2026.
It’s typically best to fly out from Mexico City to Panama in the evening. Doing so could potentially save you 24% on the flight price compared to flying at noon, which is usually more expensive.
What is the cheapest day to fly from Mexico City to Panama?
Use this chart to determine the cheapest time to fly round-trip from Mexico City to Panama. Price data was last updated on January 17, 2026.
Travelers seeking maximum savings on their Mexico City to Panama flight should consider departing on Wednesday evenings when fares are most often at their lowest. Sunday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.
Weekly flight availability from Mexico City to Panama
Explore weekly flight availability from Mexico City to Panama. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated January 20, 2026.
The most flights from MEX to PA0 are scheduled on a Tuesday (9 on average). You will have fewer flight options on Wednesday, which is when the least amount of flights are scheduled (6 on average).
How often are flights from Mexico City to Panama delayed?
About 3% of weekly flights between Mexico City and Panama have experienced delays in the past year, with the average delay time being 138 minutes.
What is the most punctual flight time for Mexico City to Panama flights?
Historically, flights departing at night are less likely to be delayed, whereas flights leaving in the early afternoon tend to experience delays more often.
What day of the week experiences the fewest flight delays on this route?
Saturday tends to have the lowest number of delays on this route, whereas Thursday has historically faced a higher average of delays compared to other days of the week.
Which airline has the best punctuality record on Mexico City to Panama flights?
Over the last year, Copa Airlines have had the lowest number of delays on this route, with just 3% of flights being delayed.
Reviews of airlines servicing Panama
Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated January 20, 2026.
Peruse reviews from past customers who have flown with Copa Airlines, Aeromexico, and Avianca from Mexico City to Panama to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
Crew
Comfort
Overall
Boarding
Food
Reviews
Juan,Dec 2025
EZE - PTY
Entertainment
Crew
Comfort
Overall
Boarding
Food
Reviews
Juan,Dec 2025
EZE - PTY
Entertainment
Crew
Comfort
Overall
Boarding
Food
Reviews
Juan,Dec 2025
EZE - PTY
Entertainment
Crew
Comfort
Overall
Boarding
Food
Reviews
Juan,Dec 2025
EZE - PTY
Related info for your journey
Find useful and relevant information for your journey from Mexico City to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Mexico City to Panama
See prices for flight routes from nearby airports that may be better suited for you.
Top 3 airlines flying from Mexico City to Panama
Discover the top 3 airlines that operate flights from Mexico City to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 20, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$171 | Average$446 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$225 | Average$363 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$328 | Average$424 | FlexibilityNo cancel fee | On-time70% |