HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Panama

$212+ Cheap flights from Detroit Metropolitan Wayne County Airport (DTW) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/10. Fares are subject to change and may not be available on all flights or dates of travel.
DTW — PTY
Feb 28 — Mar 71
Sat 2/28
Sat 3/7
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Detroit to Panama with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Detroit to Panama

Cheapest flights from Detroit to Panama
Explore the most affordable flight options available from Detroit to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 29, 2026.

This Avianca Connect deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/184:50 pm
DTW
-
PTY
2 stops17h 00m
Multiple Airlines
Wed 3/259:45 am
PTY
-
DTW
2 stops13h 14m
Multiple Airlines
Deal found 1/27$461
This Avianca Connect deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/56:05 am
DTW
-
PTY
2 stops18h 55m
Multiple Airlines
Fri 3/132:55 am
PTY
-
DTW
2 stops15h 27m
Multiple Airlines
Deal found 1/28$465
This Mytrip deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/35:09 am
DTW
-
PTY
3 stops27h 41m
Multiple Airlines
Wed 3/411:25 am
PTY
-
DTW
3 stops23h 36m
Multiple Airlines
Deal found 1/26$479
This Mytrip deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/285:00 am
DTW
-
PTY
2 stops27h 50m
Multiple Airlines
Tue 2/32:55 am
PTY
-
DTW
2 stops21h 24m
Multiple Airlines
Deal found 1/27$480
This Avianca Connect deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/105:45 am
DTW
-
PTY
2 stops20h 15m
Multiple Airlines
Mon 3/162:55 am
PTY
-
DTW
2 stops15h 51m
Multiple Airlines
Deal found 1/27$481
This Avianca Connect deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/48:49 am
DTW
-
PTY
2 stops15h 51m
Multiple Airlines
Tue 3/319:55 am
PTY
-
DTW
2 stops13h 04m
Multiple Airlines
Deal found 1/26$482
This Avianca Connect deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/45:45 am
DTW
-
PTY
2 stops18h 55m
Multiple Airlines
Wed 3/112:55 am
PTY
-
DTW
2 stops15h 51m
Multiple Airlines
Deal found 1/27$485
This Avianca Connect deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/1212:22 pm
DTW
-
PTY
2 stops14h 33m
Multiple Airlines
Thu 4/163:20 am
PTY
-
DTW
2 stops19h 39m
Multiple Airlines
Deal found 1/28$495
This Avianca Connect deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/135:00 am
DTW
-
PTY
2 stops20h 45m
Multiple Airlines
Tue 5/193:20 am
PTY
-
DTW
2 stops17h 14m
Multiple Airlines
Deal found 1/27$502
This Mytrip deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/106:00 am
DTW
-
PTY
3 stops19h 00m
Multiple Airlines
Wed 2/115:50 pm
PTY
-
DTW
3 stops19h 40m
Multiple Airlines
Deal found 1/27$508

Find flight deals from Detroit to Panama

Keep the following information in mind while searching for Detroit to Panama flight deals. Data was last updated January 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$461
(Avianca Connect)

One-way from

$212
(Kiwi.com)

Popular in

December

Cheapest in

January

Average price

$578
Provider with most accurate pricing for Detroit (DTT)-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Detroit (DTT)-Panama City Tocumen Intl flights.
Search Deals
From Detroit Metropolitan Wayne County to Panama
Search Deals
One-way flight from Detroit Metropolitan Wayne County to Panama
Search Deals
Highest demand for flights based on searches. 10% potential increase in price ($93 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($36 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Detroit to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to Panama that are best for you.

Fly from

Detroit

Fly to

Panama

Route

Depart

Return

Price

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Wed 3/18

4:50 pm-8:50 am

2 stops17h 00m

Panama City Tocumen Intl

Wed 3/25

9:45 am-11:59 pm

2 stops13h 14m

$461

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Thu 3/5

6:05 am-1:00 am

2 stops18h 55m

Panama City Tocumen Intl

Fri 3/13

2:55 am-7:22 pm

2 stops15h 27m

$465

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Wed 3/11

8:49 am-12:40 am

2 stops16h 51m

Panama City Tocumen Intl

Mon 3/16

2:55 am-7:46 pm

2 stops15h 51m

$481

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Tue 3/10

5:45 am-1:00 am

2 stops20h 15m

Panama City Tocumen Intl

Mon 3/16

2:55 am-7:46 pm

2 stops15h 51m

$481

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Wed 3/4

5:45 am-12:40 am

2 stops18h 55m

Panama City Tocumen Intl

Wed 3/11

2:55 am-7:46 pm

2 stops15h 51m

$485

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Wed 5/13

5:00 am-12:45 am

2 stops20h 45m

Panama City Tocumen Intl

Tue 5/19

3:20 am-9:34 pm

2 stops17h 14m

$502

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Thu 3/19

12:22 pm-1:00 am

2 stops13h 38m

Panama City Tocumen Intl

Mon 3/23

9:45 am-11:59 pm

2 stops13h 14m

$514

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Fri 4/24

8:00 am-12:45 am

2 stops17h 45m

Panama City Tocumen Intl

Wed 4/29

3:20 am-11:59 pm

2 stops19h 39m

$518

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Tue 3/10

8:49 am-1:00 am

2 stops17h 11m

Panama City Tocumen Intl

Sun 3/15

2:55 am-10:32 pm

2 stops18h 37m

$519

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Sat 2/14

11:20 am-1:00 am

2 stops13h 40m

Panama City Tocumen Intl

Mon 2/16

2:55 pm-9:11 am

2 stops18h 16m

$565

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/27

Showing 1-10 of 13 results
1
2

Best time to book a flight from Detroit to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Detroit with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Detroit Metropolitan Wayne County Airport to Panama

What is the cheapest month to book a flight from Detroit Metropolitan Wayne County Airport to Panama?

Currently, June is the cheapest month in which you can book a flight from Detroit Metropolitan Wayne County Airport to Panama (average of $592). Flying from Detroit Metropolitan Wayne County Airport to Panama in February is currently the most expensive (average of $811). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated January 29, 2026.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Detroit Metropolitan Wayne County Airport to Panama. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,128 reviews

Overall

7.9

Crew

8.5

Comfort

7.9

Boarding

8.1

Entertainment

7.8

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,128 reviews
Delta
7.9
Good
8,128 reviews

Overall

7.9

Crew

8.5

Comfort

7.9

Boarding

8.1

Entertainment

7.8

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,215 reviews
Delta
7.9
Good
8,128 reviews

Overall

7.9

Crew

8.5

Comfort

7.9

Boarding

8.1

Entertainment

7.8

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,205 reviews
Delta
7.9
Good
8,128 reviews

Overall

7.9

Crew

8.5

Comfort

7.9

Boarding

8.1

Entertainment

7.8

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Detroit to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Detroit to Panama?

    Detroit Metropolitan Wayne County (DTW) is the airport you will fly out of if you book a flight from Detroit to Panama. It is only a 17.3 mi journey to Detroit Metropolitan Wayne County (DTW) from Detroit’s city center.

  • Can I find deals for flights from Detroit to Panama that include hotel bookings?

    Yes. In addition to deals on Detroit to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Detroit to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Detroit to Panama.

  • Can I find deals for business class flights from Detroit to Panama?

    Yes. Cheapflights offers flight deals from Detroit to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Detroit Metropolitan Wayne County Airport to Panama?

    Currently, June is the cheapest month in which you can book a flight from Detroit Metropolitan Wayne County Airport to Panama (average of $592). Flying from Detroit Metropolitan Wayne County Airport to Panama in February is currently the most expensive (average of $811). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top 3 airlines flying from Detroit to Panama

Discover the top 3 airlines that operate flights from Detroit to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$578Average$816FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$608Average$811FlexibilityNo cancel feeOn-time69%
DeltaCheapest$608Average$934FlexibilityNo cancel feeOn-timeN/A

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.