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$185+ Cheap flights from Detroit Metropolitan Wayne County Airport (DTW) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/25. Fares are subject to change and may not be available on all flights or dates of travel.
DTW — PTY
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheap flight deals from Detroit to Panama

Keep the following information in mind while searching for Detroit to Panama flight deals. Data was last updated September 11, 2025.

Round-trip from

$419
(Avianca Connect)

One-way from

$185
(Kiwi.com)

Popular in

September

Cheapest in

August

Average price

$1,558
From Detroit Metropolitan Wayne County to Panama
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One-way flight from Detroit Metropolitan Wayne County to Panama
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Highest demand for flights based on searches. 14% potential increase in price ($137 potential increase over avg. RT price).
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Cheapest flight prices on average. 8% potential price decrease ($66 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Detroit to Panama

Cheapest flights from Detroit to Panama
Explore the most affordable flight options available from Detroit to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/116:17 amDTW - PTY
1 stop11h 08mMultiple Airlines
Sat 10/1810:25 amPTY - DTW
1 stop8h 35mMultiple Airlines
Deal found 9/11$472
This Avianca Connect deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/196:30 amDTW - PTY
2 stops15h 40mMultiple Airlines
Tue 9/2310:05 pmPTY - DTW
2 stops21h 09mMultiple Airlines
Deal found 9/10$482
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/256:43 amDTW - PTY
1 stop14h 36mMultiple Airlines
Sat 11/112:03 pmPTY - DTW
1 stop10h 27mMultiple Airlines
Deal found 9/9$486
This Avianca Connect deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/137:00 amDTW - PTY
2 stops18h 00mMultiple Airlines
Tue 11/185:55 pmPTY - DTW
2 stops20h 14mMultiple Airlines
Deal found 9/10$497
This Avianca Connect deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/137:00 amDTW - PTY
2 stops18h 00mMultiple Airlines
Sun 11/162:55 amPTY - DTW
2 stops15h 59mMultiple Airlines
Deal found 9/10$503
This Avianca Connect deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1410:49 amDTW - PTY
2 stops13h 51mMultiple Airlines
Sun 11/162:55 amPTY - DTW
2 stops15h 59mMultiple Airlines
Deal found 9/10$542
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/186:30 amDTW - PTY
1 stop10h 56mMultiple Airlines
Thu 9/2510:25 amPTY - DTW
1 stop8h 49mMultiple Airlines
Deal found 9/11$545
This Avianca Connect deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/77:00 amDTW - PTY
2 stops17h 40mMultiple Airlines
Sun 11/92:55 pmPTY - DTW
2 stops23h 14mMultiple Airlines
Deal found 9/10$558
This Avianca Connect deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/216:30 amDTW - PTY
2 stops18h 40mMultiple Airlines
Fri 9/263:25 amPTY - DTW
2 stops15h 49mMultiple Airlines
Deal found 9/10$566

Cheapflights Fare Finder

 
Customize your flight search to find flights from Detroit to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to Panama that are best for you.

Fly from

Detroit

Fly to

Panama

Route

Depart

Return

Price

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Sat 10/11

6:17 am-4:25 pm

1 stop11h 08m

Panama City Tocumen Intl

Sat 10/18

8:25 am-8:00 pm

1 stop10h 35m

$472

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Sat 10/25

6:43 am-8:19 pm

1 stop14h 36m

Panama City Tocumen Intl

Sat 11/1

12:03 pm-11:30 pm

1 stop10h 27m

$486

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Fri 11/14

7:00 am-12:40 am

2 stops17h 40m

Panama City Tocumen Intl

Mon 11/17

2:55 pm-2:09 pm

2 stops23h 14m

$497

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Thu 11/13

7:00 am-1:00 am

2 stops18h 00m

Panama City Tocumen Intl

Sun 11/16

2:55 am-6:54 pm

2 stops15h 59m

$503

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Sun 2/15

8:20 pm-2:00 pm

2 stops17h 40m

Panama City Tocumen Intl

Wed 2/25

2:55 pm-2:09 pm

2 stops23h 14m

$519

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Thu 11/13

7:00 am-1:00 am

2 stops18h 00m

Panama City Tocumen Intl

Mon 11/17

2:55 am-6:54 pm

2 stops15h 59m

$540

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Sun 9/21

6:30 am-12:10 am

2 stops18h 40m

Panama City Tocumen Intl

Fri 9/26

3:25 am-8:14 pm

2 stops15h 49m

$566

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Sun 9/21

9:12 am-12:10 am

2 stops15h 58m

Panama City Tocumen Intl

Sat 9/27

3:20 am-8:14 pm

2 stops15h 54m

$596

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Fri 11/7

7:00 am-12:40 am

2 stops17h 40m

Panama City Tocumen Intl

Sat 11/8

2:55 am-6:54 pm

2 stops15h 59m

$613

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Sat 10/25

7:15 pm-1:00 am

2 stops30h 45m

$185

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Showing 1-10 of 11 results
1
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Best time to book a flight from Detroit to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Detroit with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Detroit Metropolitan Wayne County Airport to Panama

What is the cheapest month to book a flight from Detroit Metropolitan Wayne County Airport to Panama?

Currently, October is the cheapest month in which you can book a flight from Detroit Metropolitan Wayne County Airport to Panama (average of $478). Flying from Detroit Metropolitan Wayne County Airport to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DTW to PA?

Find hourly flight availability from Detroit to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 11, 2025.

When flying from Detroit Metropolitan Wayne County Airport to Panama, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated September 11, 2025.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Detroit Metropolitan Wayne County Airport to Panama. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,960 reviews

Boarding

8.2

Crew

8.5

Entertainment

7.9

Overall

8.0

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,960 reviews
Delta
8.0
Very good
7,960 reviews

Boarding

8.2

Crew

8.5

Entertainment

7.9

Overall

8.0

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,937 reviews
Delta
8.0
Very good
7,960 reviews

Boarding

8.2

Crew

8.5

Entertainment

7.9

Overall

8.0

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,960 reviews

Boarding

8.2

Crew

8.5

Entertainment

7.9

Overall

8.0

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Detroit to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Detroit to Panama?

    Detroit Metropolitan Wayne County (DTW) is the airport you will fly out of if you book a flight from Detroit to Panama. It is only a 17.3 mi journey to Detroit Metropolitan Wayne County (DTW) from Detroit’s city center.

  • Can I find deals for flights from Detroit to Panama that include hotel bookings?

    Yes. In addition to deals on Detroit to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Detroit to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Detroit to Panama.

  • Can I find deals for business class flights from Detroit to Panama?

    Yes. Cheapflights offers flight deals from Detroit to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Detroit Metropolitan Wayne County Airport to Panama?

    Currently, October is the cheapest month in which you can book a flight from Detroit Metropolitan Wayne County Airport to Panama (average of $478). Flying from Detroit Metropolitan Wayne County Airport to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top 3 airlines flying from Detroit to Panama

Discover the top 3 airlines that operate flights from Detroit to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$578Average$781FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$608Average$855FlexibilityNo cancel feeOn-time69%
DeltaCheapest$608Average$918FlexibilityNo cancel feeOn-timeN/A

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