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$209+ Cheap flights from Detroit Metropolitan Wayne County Airport (DTW) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/3. Fares are subject to change and may not be available on all flights or dates of travel.
DTW — PTY
Nov 28 — Dec 51
Fri 11/28
Fri 12/5
1 adult, Economy
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Cheap flight deals from Detroit to Panama

Keep the following information in mind while searching for Detroit to Panama flight deals. Data was last updated October 29, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$490
(Kiwi.com)

One-way from

$209
(Kiwi.com)

Popular in

December

Cheapest in

August

Average price

$748
Provider with most accurate pricing for Detroit (DTT)-Panama City Tocumen Intl flight deals.
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Provider most trusted by Cheapflights users for Detroit (DTT)-Panama City Tocumen Intl flights.
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From Detroit Metropolitan Wayne County to Panama
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One-way flight from Detroit Metropolitan Wayne County to Panama
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Highest demand for flights based on searches. 14% potential increase in price ($138 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($30 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Detroit to Panama

Cheapest flights from Detroit to Panama
Explore the most affordable flight options available from Detroit to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 29, 2025.

This Mytrip deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/310:47 amDTW - PTY
3 stops32h 08mMultiple Airlines
Sat 12/1311:25 amPTY - DTW
2 stops12h 54mMultiple Airlines
Deal found 10/28$515
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/127:10 amDTW - PTY
2 stops27h 20mMultiple Airlines
Wed 11/1910:47 amPTY - DTW
1 stop10h 55mMultiple Airlines
Deal found 10/29$557
This Mytrip deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/183:12 pmDTW - PTY
3 stops17h 38mMultiple Airlines
Wed 11/1911:25 amPTY - DTW
2 stops12h 29mMultiple Airlines
Deal found 10/26$562
This Mytrip deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/107:17 pmDTW - PTY
2 stops23h 38mMultiple Airlines
Tue 12/25:50 pmPTY - DTW
3 stops30h 08mMultiple Airlines
Deal found 10/27$564
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/127:10 amDTW - PTY
2 stops27h 20mMultiple Airlines
Tue 11/189:33 pmPTY - DTW
1 stop16h 56mMultiple Airlines
Deal found 10/29$570
This Mytrip deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/113:12 pmDTW - PTY
3 stops33h 28mMultiple Airlines
Tue 12/25:50 pmPTY - DTW
3 stops29h 10mMultiple Airlines
Deal found 10/27$571

Cheapflights Fare Finder

 
Customize your flight search to find flights from Detroit to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 29, 2025.
Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to Panama that are best for you.

Fly from

Detroit

Fly to

Panama

Route

Depart

Return

Price

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Tue 2/3

7:00 am-1:00 am

2 stops18h 00m

Panama City Tocumen Intl

Thu 2/5

2:55 am-9:23 pm

2 stops18h 28m

$503

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Wed 2/18

8:20 pm-8:50 am

2 stops12h 30m

Panama City Tocumen Intl

Wed 2/25

2:55 pm-10:05 am

2 stops19h 10m

$514

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Wed 12/3

10:47 am-6:55 pm

3 stops32h 08m

Panama City Tocumen Intl

Fri 12/12

2:55 am-12:09 am

3 stops21h 14m

$548

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Sun 2/15

8:20 pm-2:00 pm

2 stops17h 40m

Panama City Tocumen Intl

Sun 2/22

5:50 pm-10:05 am

2 stops16h 15m

$561

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Thu 11/13

7:10 am-1:00 am

2 stops17h 50m

Panama City Tocumen Intl

Fri 12/12

2:55 am-9:03 pm

2 stops18h 08m

$565

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Tue 11/25

6:35 am-1:00 am

2 stops18h 25m

Panama City Tocumen Intl

Mon 12/1

2:55 am-11:54 pm

2 stops20h 59m

$565

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Wed 11/12

7:10 am-10:30 am

2 stops27h 20m

Panama City Tocumen Intl

Tue 11/18

9:33 pm-2:29 pm

1 stop16h 56m

$570

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Tue 11/18

3:12 pm-8:50 am

3 stops17h 38m

Panama City Tocumen Intl

Wed 11/19

11:25 am-1:00 pm

3 stops25h 35m

$586

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Mon 11/10

7:17 pm-6:55 pm

2 stops23h 38m

Panama City Tocumen Intl

Tue 12/2

5:50 pm-2:29 pm

2 stops20h 39m

$588

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Wed 12/3

7:10 am-10:30 am

2 stops27h 20m

$209

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/27

Showing 1-10 of 12 results
1
2

Best time to book a flight from Detroit to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Detroit with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Detroit Metropolitan Wayne County Airport to Panama

What is the cheapest month to book a flight from Detroit Metropolitan Wayne County Airport to Panama?

Currently, June is the cheapest month in which you can book a flight from Detroit Metropolitan Wayne County Airport to Panama (average of $594). Flying from Detroit Metropolitan Wayne County Airport to Panama in August is currently the most expensive (average of $756). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DTW to PA?

Find hourly flight availability from Detroit to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 29, 2025.

It’s typically best to fly out from Detroit Metropolitan Wayne County Airport to Panama in the morning. Doing so could potentially save you 73% on the flight price compared to flying in the afternoon, which is usually more expensive.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated October 29, 2025.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Detroit Metropolitan Wayne County Airport to Panama. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,992 reviews

Crew

8.5

Food

7.3

Boarding

8.2

Entertainment

7.9

Overall

7.9

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
7.9
Good
7,992 reviews
Delta
7.9
Good
7,992 reviews

Crew

8.5

Food

7.3

Boarding

8.2

Entertainment

7.9

Overall

7.9

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
United Airlines
7.4
Good
8,999 reviews
Delta
7.9
Good
7,992 reviews

Crew

8.5

Food

7.3

Boarding

8.2

Entertainment

7.9

Overall

7.9

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,032 reviews
Delta
7.9
Good
7,992 reviews

Crew

8.5

Food

7.3

Boarding

8.2

Entertainment

7.9

Overall

7.9

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Detroit to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Detroit to Panama?

    Detroit Metropolitan Wayne County (DTW) is the airport you will fly out of if you book a flight from Detroit to Panama. It is only a 17.3 mi journey to Detroit Metropolitan Wayne County (DTW) from Detroit’s city center.

  • Can I find deals for flights from Detroit to Panama that include hotel bookings?

    Yes. In addition to deals on Detroit to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Detroit to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Detroit to Panama.

  • Can I find deals for business class flights from Detroit to Panama?

    Yes. Cheapflights offers flight deals from Detroit to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Detroit Metropolitan Wayne County Airport to Panama?

    Currently, June is the cheapest month in which you can book a flight from Detroit Metropolitan Wayne County Airport to Panama (average of $594). Flying from Detroit Metropolitan Wayne County Airport to Panama in August is currently the most expensive (average of $756). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from Detroit to Panama

Discover the top 3 airlines that operate flights from Detroit to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$578Average$800FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$608Average$851FlexibilityNo cancel feeOn-time69%
DeltaCheapest$608Average$937FlexibilityNo cancel feeOn-timeN/A

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