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$160+ Cheap flights from Key Largo, FL to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/29. Fares are subject to change and may not be available on all flights or dates of travel.
MIA — PTY
Mar 9 — Mar 161
Mon 3/9
Mon 3/16
1 adult, Economy
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Cheapflights Tip: The best prices from Key Largo to Panama City Tocumen Intl are usually found in May or July, booked 78 days in advance, depart on a Thursday or Wednesday and return on a Tuesday

Cheap flight deals from Key Largo to Panama City

Cheapest flights from Key Largo to Panama City
Explore the most affordable flight options available from Key Largo to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 7, 2026.

This Avianca deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/202:00 pm
MIA
-
PTY
1 stop11h 40m
Avianca
Sun 3/222:55 am
PTY
-
MIA
1 stop8h 35m
Avianca
Deal found 2/6$329
This Avianca deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/104:50 pm
MIA
-
PTY
2 stops17h 40m
Avianca
Sat 2/142:55 pm
PTY
-
MIA
1 stop7h 35m
Avianca
Deal found 2/6$330
This Avianca deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/145:35 pm
MIA
-
PTY
1 stop8h 25m
Avianca
Sun 3/222:55 pm
PTY
-
MIA
1 stop12h 15m
Avianca
Deal found 2/4$332
This United Airlines deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/266:15 am
MIA
-
PTY
1 stop8h 30m
United Airlines
Fri 2/274:41 pm
PTY
-
MIA
1 stop18h 14m
United Airlines
Deal found 2/6$333
This Avianca deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/104:50 pm
MIA
-
PTY
2 stops17h 40m
Avianca
Tue 2/172:55 pm
PTY
-
MIA
1 stop7h 35m
Avianca
Deal found 2/5$334
This Avianca deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/203:50 pm
MIA
-
PTY
1 stop11h 05m
Avianca
Tue 5/265:30 am
PTY
-
MIA
2 stops7h 30m
Avianca
Deal found 2/3$335
This Avianca deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/145:35 pm
MIA
-
PTY
1 stop8h 25m
Avianca
Sat 3/215:50 pm
PTY
-
MIA
1 stop9h 20m
Avianca
Deal found 2/3$336
This American Airlines deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1812:05 pm
MIA
-
PTY
Nonstop3h 15m
American Airlines
Sun 8/233:20 pm
PTY
-
MIA
Nonstop3h 05m
American Airlines
Deal found 2/6$337
This Trip.com deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/97:00 am
MIA
-
PTY
1 stop17h 40m
Avianca
Wed 2/112:55 pm
PTY
-
MIA
1 stop7h 35m
Avianca
Deal found 2/6$338
This Avianca deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/254:50 pm
MIA
-
PTY
3 stops16h 00m
Avianca
Sun 3/15:50 pm
PTY
-
MIA
1 stop9h 20m
Avianca
Deal found 2/4$339
This Gotogate deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/215:35 pm
MIA
-
PTY
1 stop21h 25m
Avianca
Sun 3/295:55 pm
PTY
-
MIA
1 stop28h 35m
Avianca
Deal found 2/4$340
This Gotogate deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/67:00 am
MIA
-
PTY
1 stop25h 50m
Avianca
Mon 2/99:45 am
PTY
-
MIA
1 stop12h 45m
Avianca
Deal found 2/5$341

Find flight deals from Key Largo to Panama City

Keep the following information in mind while searching for Key Largo to Panama City flight deals. Data was last updated February 7, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$329
(Avianca)

One-way from

$160
(Avianca)

Popular in

December

Cheapest in

May

Average price

$338
Provider with most accurate pricing for Miami-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Miami-Panama City Tocumen Intl flights.
Search Deals
From Key Largo to Panama City Tocumen Intl
Search Deals
One-way flight from Key Largo to Panama City Tocumen Intl
Search Deals
Highest demand for flights based on searches. 17% potential increase in price ($69 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($13 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Key Largo to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 7, 2026.
Use the filters below to find and compare flights from Key Largo to Panama City that are best for you.

Fly from

Key Largo

Fly to

Panama City

Route

Depart

Return

Price

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Wed 4/1

9:00 am-6:37 pm

1 stop10h 37m

Panama City Tocumen Intl

Mon 4/6

3:30 pm-11:09 am

1 stop18h 39m

$333

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Mon 2/23

6:15 am-5:07 pm

1 stop10h 52m

Panama City Tocumen Intl

Wed 3/4

8:55 am-6:16 pm

1 stop9h 21m

$333

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Sat 4/11

6:15 am-6:37 pm

1 stop13h 22m

Panama City Tocumen Intl

Mon 4/13

3:30 pm-11:09 am

1 stop18h 39m

$333

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Wed 4/1

9:00 am-4:12 pm

1 stop8h 12m

Panama City Tocumen Intl

Tue 4/7

3:30 pm-11:09 am

1 stop18h 39m

$333

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Tue 3/17

10:22 am-6:38 pm

1 stop9h 16m

Panama City Tocumen Intl

Tue 3/24

3:41 pm-10:55 am

1 stop18h 14m

$333

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Wed 2/25

8:45 am-7:38 pm

1 stop10h 53m

Panama City Tocumen Intl

Thu 3/5

8:55 am-6:31 pm

1 stop9h 36m

$343

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Tue 2/24

8:45 am-7:38 pm

1 stop10h 53m

Panama City Tocumen Intl

Thu 3/5

8:55 am-6:31 pm

1 stop9h 36m

$343

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Thu 2/26

8:45 am-5:07 pm

1 stop8h 22m

Panama City Tocumen Intl

Tue 3/3

8:55 am-9:59 pm

1 stop13h 04m

$343

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Tue 2/24

8:45 am-5:07 pm

1 stop8h 22m

Panama City Tocumen Intl

Tue 3/3

8:55 am-6:16 pm

1 stop9h 21m

$343

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Fri 3/20

5:35 pm-12:40 am

1 stop8h 05m

Panama City Tocumen Intl

Thu 3/26

2:55 am-12:30 pm

1 stop8h 35m

$350

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/5

Showing 1-10 of 21 results
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Best time to book a flight from Key Largo to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Key Largo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key Largo to Panama City

How far ahead should I book a flight from Key Largo to Panama City?

Use this chart to determine the optimal time to book a round-trip flight from Key Largo to Panama City. Price data was last updated on January 30, 2026.

Booking 78 days in advance of your planned departure date is, on average, the best time to get cheap flights from Key Largo to Panama City. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Key Largo to Panama City?

Currently, July is the cheapest month in which you can book a flight from Key Largo to Panama City (average of $166). Flying from Key Largo to Panama City in March is currently the most expensive (average of $278). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from KE9 to PTY?

Find hourly flight availability from Key Largo to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 7, 2026.

It’s typically best to fly out from Key Largo to Panama City at noon. Doing so could potentially save you 18% on the flight price compared to flying in the evening, which is usually more expensive.

What is the cheapest day to fly from Key Largo to Panama City?

Use this chart to determine the cheapest time to fly round-trip from Key Largo to Panama City. Price data was last updated on January 31, 2026.

Travelers seeking maximum savings on their Key Largo to Panama City flight should consider departing on Tuesday at noon when fares are most often at their lowest. Tuesday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Key Largo to Panama City

Explore weekly flight availability from Key Largo to Panama City. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated February 7, 2026.

The most flights from KE9 to PTY are scheduled on a Thursday (15 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (11 on average).

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated February 7, 2026.
See what other customers who have flown with Copa Airlines, United Airlines, and American Airlines from Key Largo to Panama City have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.5
Good
1,556 reviews

Crew

8.1

Food

6.8

Entertainment

6.8

Overall

7.5

Comfort

7.4

Boarding

7.8

Reviews

1 / 20
2.0
Mediocre

Juan,Dec 2025

EZE - PTY

The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.
Copa Airlines
7.5
Good
1,556 reviews
Copa Airlines
7.5
Good
1,556 reviews

Crew

8.1

Food

6.8

Entertainment

6.8

Overall

7.5

Comfort

7.4

Boarding

7.8

Reviews

1 / 20
2.0
Mediocre

Juan,Dec 2025

EZE - PTY

The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.
United Airlines
7.4
Good
9,245 reviews
Copa Airlines
7.5
Good
1,556 reviews

Crew

8.1

Food

6.8

Entertainment

6.8

Overall

7.5

Comfort

7.4

Boarding

7.8

Reviews

1 / 20
2.0
Mediocre

Juan,Dec 2025

EZE - PTY

The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.
American Airlines
7.2
Good
11,247 reviews
Copa Airlines
7.5
Good
1,556 reviews

Crew

8.1

Food

6.8

Entertainment

6.8

Overall

7.5

Comfort

7.4

Boarding

7.8

Reviews

1 / 20
2.0
Mediocre

Juan,Dec 2025

EZE - PTY

The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.
Avianca
6.5
Okay
2,498 reviews
Copa Airlines
7.5
Good
1,556 reviews

Crew

8.1

Food

6.8

Entertainment

6.8

Overall

7.5

Comfort

7.4

Boarding

7.8

Reviews

1 / 20
2.0
Mediocre

Juan,Dec 2025

EZE - PTY

The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.

Related info for your journey

Find useful and relevant information for your journey from Key Largo to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Panama City from Key Largo?

    For a flight from Key Largo to Panama City, you will be flying into Tocumen Intl. Panama City Tocumen Intl (PTY) is just 11.4 mi from the center of the city. Tocumen Intl is the only Panama City airport and it handles 13 inbound flights from Key Largo per day. 4 airlines have flights to Panama City Tocumen Intl from Key Largo on a regular basis.

  • How popular is this Key Largo to Panama City flight route?

    Flights from Key Largo to Panama City Tocumen Intl have been viewed 316 times in the past calendar month.

  • How long is the flight from Key Largo to Panama City?

    A quick flight from Key Largo to Panama City can take about 10h 37m. United Airlines provides one of the quickest options available for as low as $333. Airlines will cover a distance of 1156 mi.

  • What are the cheapest airlines to fly from Key Largo to Panama City one-way?

    The cheapest airline one-way is Avianca, with whom users have recently found tickets for as low as $92. However, be on the lookout for offers from Copa Airlines and American Airlines, as they are both options that can get you from Key Largo to Panama City for a low price.

  • What are the most reliable airlines from Key Largo to Panama City?

    The top 3 most reliable airlines when flying from Key Largo to Panama City are Qatar Airways (93%), United Airlines (91%) and American Airlines (89%).

  • What are the cheapest flights from Key Largo to Panama City?

    Looking at all options, your cheapest flight can be booked for $150. While the most popular route (Miami - Panama City Tocumen Intl) can be booked for $312 on average, our data indicates $827 when flying from Key Largo to Panama City.

  • Can I find deals for flights from Key Largo to Panama City that include hotel bookings?

    Yes. In addition to deals on Key Largo to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key Largo to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key Largo to Panama City.

  • Can I find deals for business class flights from Key Largo to Panama City?

    Yes. Cheapflights offers flight deals from Key Largo to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Key Largo to Panama City?

    Currently, July is the cheapest month in which you can book a flight from Key Largo to Panama City (average of $166). Flying from Key Largo to Panama City in March is currently the most expensive (average of $278). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 4 airlines flying from Key Largo to Panama City

Discover the top 4 airlines that operate flights from Key Largo to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 7, 2026.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$127Average$352FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$265Average$331FlexibilityNo cancel feeOn-time70%
American AirlinesCheapest$275Average$431FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$290Average$661FlexibilityNo cancel feeOn-time69%

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