HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Panama City

$126+ Cheap flights from Key Largo, FL to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/14. Fares are subject to change and may not be available on all flights or dates of travel.
MIA — PTY
Dec 6 — Dec 131
Sat 12/6
Sat 12/13
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Key Largo to Panama City with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Key Largo to Panama City Tocumen Intl are usually found in May or July, booked 78 days in advance, depart on a Thursday or Wednesday and return on a Thursday

Find flight deals from Key Largo to Panama City

Cheapest flights from Key Largo to Panama City
Explore the most affordable flight options available from Key Largo to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 6, 2025.

This Copa Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/44:59 amMIA - PTY
Nonstop3h 07mCopa Airlines
Sat 2/286:34 pmPTY - MIA
Nonstop3h 09mCopa Airlines
Deal found 11/6$276
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/812:25 pmMIA - PTY
Nonstop3h 17mAmerican Airlines
Sun 12/144:43 pmPTY - MIA
Nonstop3h 17mAmerican Airlines
Deal found 11/5$281
This Copa Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/44:59 amMIA - PTY
Nonstop3h 07mCopa Airlines
Tue 12/98:10 amPTY - MIA
Nonstop3h 11mCopa Airlines
Deal found 11/6$286
This Kiwi.com deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/131:28 pmMIA - PTY
Nonstop3h 08mCopa Airlines
Fri 11/148:25 amPTY - MIA
Nonstop3h 11mCopa Airlines
Deal found 11/6$293
This Cheapflightsfares deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/131:00 pmMIA - PTY
1 stop12h 00mAvianca
Mon 11/172:55 amPTY - MIA
1 stop8h 35mAvianca
Deal found 11/6$309
This Cheapflightsfares deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/135:10 amMIA - PTY
2 stops13h 45mAvianca
Sun 11/162:55 pmPTY - MIA
1 stop7h 35mAvianca
Deal found 11/5$310
This Kiwi.com deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/34:59 amMIA - PTY
Nonstop3h 07mCopa Airlines
Thu 12/116:34 pmPTY - MIA
Nonstop3h 11mCopa Airlines
Deal found 11/6$313
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/54:59 amMIA - PTY
Nonstop3h 07mCopa Airlines
Thu 12/119:33 pmPTY - MIA
Nonstop3h 12mCopa Airlines
Deal found 11/5$315
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/45:34 amMIA - PTY
Nonstop3h 06mCopa Airlines
Tue 12/96:34 pmPTY - MIA
Nonstop3h 11mCopa Airlines
Deal found 11/5$317
This Cheapflightsfares deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/262:05 amMIA - PTY
1 stop6h 45mAvianca
Mon 12/15:50 pmPTY - MIA
1 stop9h 20mAvianca
Deal found 11/6$318
This FlightHub deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/95:10 amMIA - PTY
1 stop13h 45mAvianca
Fri 11/142:55 amPTY - MIA
1 stop14h 10mAvianca
Deal found 11/5$319
This Cheapflightsfares deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/74:50 pmMIA - PTY
2 stops17h 40mAvianca
Sat 11/159:45 amPTY - MIA
1 stop12h 45mAvianca
Deal found 11/5$320

Cheap flight deals from Key Largo to Panama City

Keep the following information in mind while searching for Key Largo to Panama City flight deals. Data was last updated November 6, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$276
(Copa Airlines)

One-way from

$126
(Mytrip)

Popular in

December

Cheapest in

May

Average price

$312
Provider with most accurate pricing for Miami-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Miami-Panama City Tocumen Intl flights.
Search Deals
From Key Largo to Panama City Tocumen Intl
Search Deals
One-way flight from Key Largo to Panama City Tocumen Intl
Search Deals
Highest demand for flights based on searches. 13% potential increase in price ($49 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($13 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Key Largo to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
Use the filters below to find and compare flights from Key Largo to Panama City that are best for you.

Fly from

Key Largo

Fly to

Panama City

Route

Depart

Return

Price

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Wed 2/18

5:01 am-8:06 am

Nonstop3h 05m

Panama City Tocumen Intl

Sun 2/22

3:39 pm-6:56 pm

Nonstop3h 17m

$276

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Thu 1/8

4:12 pm-7:20 pm

Nonstop3h 08m

Panama City Tocumen Intl

Sat 1/17

6:34 pm-9:43 pm

Nonstop3h 09m

$276

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Sun 2/8

5:36 am-8:40 am

Nonstop3h 04m

Panama City Tocumen Intl

Sun 2/22

3:39 pm-6:56 pm

Nonstop3h 17m

$276

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Mon 1/5

5:01 am-8:06 am

Nonstop3h 05m

Panama City Tocumen Intl

Fri 1/16

6:34 pm-9:43 pm

Nonstop3h 09m

$276

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Mon 2/9

5:36 am-8:40 am

Nonstop3h 04m

Panama City Tocumen Intl

Mon 2/23

3:39 pm-6:56 pm

Nonstop3h 17m

$276

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Thu 1/8

5:26 am-8:30 am

Nonstop3h 04m

Panama City Tocumen Intl

Fri 1/23

6:15 pm-9:24 pm

Nonstop3h 09m

$276

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Mon 2/16

5:36 am-8:40 am

Nonstop3h 04m

Panama City Tocumen Intl

Mon 2/23

9:33 pm-12:37 am

Nonstop3h 04m

$276

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Wed 2/18

5:01 am-8:06 am

Nonstop3h 05m

Panama City Tocumen Intl

Wed 2/18

12:33 pm-3:41 pm

Nonstop3h 08m

$286

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Fri 12/26

4:10 pm-7:20 pm

Nonstop3h 10m

Panama City Tocumen Intl

Sat 2/28

6:34 pm-9:43 pm

Nonstop3h 09m

$329

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Thu 12/4

4:59 am-8:06 am

Nonstop3h 07m

Panama City Tocumen Intl

Fri 12/12

6:34 pm-9:45 pm

Nonstop3h 11m

$343

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/6

Showing 1-10 of 18 results
1
2

Best time to book a flight from Key Largo to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Key Largo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key Largo to Panama City

How far ahead should I book a flight from Key Largo to Panama City?

Use this chart to determine the optimal time to book a round-trip flight from Key Largo to Panama City. Price data was last updated on October 31, 2025.

Booking 78 days in advance of your planned departure date is, on average, the best time to get cheap flights from Key Largo to Panama City. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Key Largo to Panama City?

Currently, July is the cheapest month in which you can book a flight from Key Largo to Panama City (average of $132). Flying from Key Largo to Panama City in March is currently the most expensive (average of $271). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from KE9 to PTY?

Find hourly flight availability from Key Largo to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 6, 2025.

It’s typically best to fly out from Key Largo to Panama City in the evening. Doing so could potentially save you 41% on the flight price compared to flying in the afternoon, which is usually more expensive.

What is the cheapest day to fly from Key Largo to Panama City?

Use this chart to determine the cheapest time to fly round-trip from Key Largo to Panama City. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Key Largo to Panama City flight should consider departing on Tuesday evenings when fares are most often at their lowest. Saturday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Key Largo to Panama City

Explore weekly flight availability from Key Largo to Panama City. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated November 6, 2025.

The most flights from KE9 to PTY are scheduled on a Tuesday (14 on average). You will have fewer flight options on Friday, which is when the least amount of flights are scheduled (11 on average).

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated November 6, 2025.
See what other customers who have flown with Copa Airlines, United Airlines, and American Airlines from Key Largo to Panama City have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,561 reviews

Food

6.9

Comfort

7.4

Boarding

7.8

Overall

7.6

Crew

8.1

Entertainment

6.8

Reviews

1 / 20
10.0
Excellent

Juan Pablo,Sep 2025

MEX - PTY

never better, had a very plesent trip to panama, cant say the same thing of my trip, from panama to santa cruz... it was very poor, unconftrable and boring
Copa Airlines
7.6
Good
1,561 reviews
Copa Airlines
7.6
Good
1,561 reviews

Food

6.9

Comfort

7.4

Boarding

7.8

Overall

7.6

Crew

8.1

Entertainment

6.8

Reviews

1 / 20
10.0
Excellent

Juan Pablo,Sep 2025

MEX - PTY

never better, had a very plesent trip to panama, cant say the same thing of my trip, from panama to santa cruz... it was very poor, unconftrable and boring
United Airlines
7.4
Good
9,003 reviews
Copa Airlines
7.6
Good
1,561 reviews

Food

6.9

Comfort

7.4

Boarding

7.8

Overall

7.6

Crew

8.1

Entertainment

6.8

Reviews

1 / 20
10.0
Excellent

Juan Pablo,Sep 2025

MEX - PTY

never better, had a very plesent trip to panama, cant say the same thing of my trip, from panama to santa cruz... it was very poor, unconftrable and boring
American Airlines
7.2
Good
11,041 reviews
Copa Airlines
7.6
Good
1,561 reviews

Food

6.9

Comfort

7.4

Boarding

7.8

Overall

7.6

Crew

8.1

Entertainment

6.8

Reviews

1 / 20
10.0
Excellent

Juan Pablo,Sep 2025

MEX - PTY

never better, had a very plesent trip to panama, cant say the same thing of my trip, from panama to santa cruz... it was very poor, unconftrable and boring
Avianca
6.6
Okay
2,469 reviews
Copa Airlines
7.6
Good
1,561 reviews

Food

6.9

Comfort

7.4

Boarding

7.8

Overall

7.6

Crew

8.1

Entertainment

6.8

Reviews

1 / 20
10.0
Excellent

Juan Pablo,Sep 2025

MEX - PTY

never better, had a very plesent trip to panama, cant say the same thing of my trip, from panama to santa cruz... it was very poor, unconftrable and boring

Related info for your journey

Find useful and relevant information for your journey from Key Largo to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Panama City from Key Largo?

    For a flight from Key Largo to Panama City, you will be flying into Tocumen Intl. Panama City Tocumen Intl (PTY) is just 11.4 mi from the center of the city. Tocumen Intl is the only Panama City airport and it handles 12 inbound flights from Key Largo per day. 4 airlines have flights to Panama City Tocumen Intl from Key Largo on a regular basis.

  • How popular is this Key Largo to Panama City flight route?

    Flights from Key Largo to Panama City Tocumen Intl have been viewed 305 times in the past calendar month.

  • How long is the flight from Key Largo to Panama City?

    A quick flight from Key Largo to Panama City can take about 3h 05m. Copa Airlines provides one of the quickest options available for as low as $276. Airlines will cover a distance of 1156 mi. All flights are typically nonstop.

  • What are the cheapest airlines to fly from Key Largo to Panama City one-way?

    The cheapest airline one-way is Avianca, with whom users have recently found tickets for as low as $134. However, be on the lookout for offers from Copa Airlines and United Airlines, as they are both options that can get you from Key Largo to Panama City for a low price.

  • What are the most reliable airlines from Key Largo to Panama City?

    The top 3 most reliable airlines when flying from Key Largo to Panama City are Qatar Airways (100%), American Airlines (91%) and Iberia (91%).

  • What are the cheapest flights from Key Largo to Panama City?

    Looking at all options, your cheapest flight can be booked for $126. While the most popular route (Miami - Panama City Tocumen Intl) can be booked for $247 on average, our data indicates $802 when flying from Key Largo to Panama City.

  • Can I find deals for flights from Key Largo to Panama City that include hotel bookings?

    Yes. In addition to deals on Key Largo to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key Largo to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key Largo to Panama City.

  • Can I find deals for business class flights from Key Largo to Panama City?

    Yes. Cheapflights offers flight deals from Key Largo to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Key Largo to Panama City?

    Currently, July is the cheapest month in which you can book a flight from Key Largo to Panama City (average of $132). Flying from Key Largo to Panama City in March is currently the most expensive (average of $271). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top 4 airlines flying from Key Largo to Panama City

Discover the top 4 airlines that operate flights from Key Largo to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$136Average$354FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$263Average$312FlexibilityNo cancel feeOn-time70%
American AirlinesCheapest$271Average$408FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$290Average$437FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.