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$880+ Cheap flights from Des Moines (DSM) to OR Tambo (JNB)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/6. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — JNB
Nov 27 — Dec 41
Thu 11/27
Thu 12/4
1 adult, Economy
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Cheap flight deals from Des Moines to OR Tambo

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to OR Tambo (JNB). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 28, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$1,236
(American Airlines)

One-way from

$880
(American Airlines)

Popular in

June

Cheapest in

January

Average price

$1,882
Provider with most accurate pricing for Des Moines-Johannesburg OR Tambo flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Johannesburg OR Tambo flights.
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From Des Moines to Johannesburg OR Tambo
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One-way flight from Des Moines to Johannesburg OR Tambo
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Highest demand for flights based on searches. 11% potential increase in price ($219 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($47 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Des Moines to OR Tambo

Cheapest flights from Des Moines to OR Tambo
Explore the most affordable flight options available from Des Moines to OR Tambo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 28, 2025.

This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/305:26 pmDSM - JNB
2 stops32h 59mAmerican Airlines
Mon 12/2910:00 pmJNB - DSM
2 stops28h 22mAmerican Airlines
Deal found 10/27$1,236
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/95:01 pmDSM - JNB
2 stops33h 24mAmerican Airlines
Tue 12/167:35 pmJNB - DSM
2 stops31h 00mAmerican Airlines
Deal found 10/28$1,388
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/105:01 pmDSM - JNB
2 stops33h 24mAmerican Airlines
Wed 12/1710:00 pmJNB - DSM
2 stops33h 30mAmerican Airlines
Deal found 10/26$1,557
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/114:07 pmDSM - JNB
2 stops31h 28mAmerican Airlines
Thu 12/187:35 pmJNB - DSM
2 stops29h 34mAmerican Airlines
Deal found 10/27$1,608
This Flysmarter deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flysmarter is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/114:07 pmDSM - JNB
2 stops31h 28mBritish Airways
Thu 12/187:35 pmJNB - DSM
2 stops36h 00mBritish Airways
Deal found 10/27$1,618
This lastminute.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure lastminute.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/101:17 pmDSM - JNB
2 stops37h 08mBritish Airways
Wed 12/177:35 pmJNB - DSM
2 stops49h 13mBritish Airways
Deal found 10/27$1,743

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to OR Tambo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 28, 2025.
Use the filters below to find and compare flights from Des Moines to Johannesburg OR Tambo Airport that are best for you.

Fly from

Des Moines

Fly to

OR Tambo

Route

Depart

Return

Price

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Sun 11/30

5:26 pm-10:25 am

2 stops32h 59m

Johannesburg OR Tambo

Mon 12/29

10:00 pm-6:22 pm

2 stops28h 22m

$1,236

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Thu 3/5

4:27 pm-7:35 am

2 stops31h 08m

Johannesburg OR Tambo

Mon 3/9

7:35 pm-9:53 pm

2 stops33h 18m

$1,236

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Sun 4/5

6:20 pm-9:25 am

2 stops32h 05m

Johannesburg OR Tambo

Sun 4/12

9:15 pm-6:04 pm

2 stops27h 49m

$1,511

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Wed 12/10

5:01 pm-10:25 am

2 stops33h 24m

Johannesburg OR Tambo

Wed 12/17

10:00 pm-11:30 pm

2 stops33h 30m

$1,572

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Thu 12/11

4:07 pm-7:35 am

2 stops31h 28m

Johannesburg OR Tambo

Thu 12/18

7:35 pm-11:35 pm

2 stops36h 00m

$1,618

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Thu 3/5

5:45 am-7:00 pm

1 stop29h 15m

Johannesburg OR Tambo

Mon 3/9

11:59 pm-10:28 pm

2 stops29h 29m

$1,633

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Sun 4/5

11:04 am-7:40 pm

1 stop25h 36m

Johannesburg OR Tambo

Sun 4/12

11:15 pm-9:17 pm

2 stops29h 02m

$1,733

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Wed 12/10

5:01 pm-10:25 am

2 stops33h 24m

Johannesburg OR Tambo

Wed 12/17

7:35 pm-12:48 pm

2 stops49h 13m

$1,798

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Thu 12/11

11:35 am-6:35 pm

2 stops23h 00m

$1,273

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Sat 12/6

3:00 pm-7:00 pm

1 stop20h 00m

$1,273

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/27

Showing 1-10 of 17 results
1
2

Compare providers for flights from Des Moines to OR Tambo

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to OR Tambo in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
OvagoPrice Accuracy2 starsTrust Score*2 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars
AranGrantPrice Accuracy2 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Johannesburg OR Tambo Airport flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Des Moines-Johannesburg OR Tambo Airport flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Des Moines-Johannesburg OR Tambo Airport flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Johannesburg OR Tambo Airport flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Johannesburg OR Tambo Airport flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to OR Tambo

Have a flexible travel schedule? Discover the best time to fly to OR Tambo from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Johannesburg OR Tambo Airport

What is the cheapest month to book a flight from Des Moines to Johannesburg OR Tambo Airport?

Currently, January is the cheapest month in which you can book a flight from Des Moines to Johannesburg OR Tambo Airport (average of $1,219). Flying from Des Moines to Johannesburg OR Tambo Airport in October is currently the most expensive (average of $1,882). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to JNB?

Find hourly flight availability from Des Moines to OR Tambo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 28, 2025.

It’s optimal to fly from Des Moines to Johannesburg OR Tambo Airport in the afternoon. By choosing this option you can save up to 20% on the cost of your flight, compared to a flight at noon.

Reviews of airlines servicing OR Tambo

Get insights into the airlines that provide service to OR Tambo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to OR Tambo. Reviews last updated October 28, 2025.
See what other customers who have flown with Delta and United Airlines from Des Moines to Johannesburg OR Tambo Airport have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,994 reviews

Boarding

8.2

Crew

8.5

Overall

7.9

Comfort

7.9

Food

7.3

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
7.9
Good
7,994 reviews
Delta
7.9
Good
7,994 reviews

Boarding

8.2

Crew

8.5

Overall

7.9

Comfort

7.9

Food

7.3

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
United Airlines
7.4
Good
9,001 reviews
Delta
7.9
Good
7,994 reviews

Boarding

8.2

Crew

8.5

Overall

7.9

Comfort

7.9

Food

7.3

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to OR Tambo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Johannesburg OR Tambo?

    Des Moines (DSM), located 3.6 mi from the city center, is the airport you fly out of when you book flights from Des Moines to Johannesburg OR Tambo. 2 airlines have flights from Des Moines to Johannesburg OR Tambo on a regular basis. Booking flights from Des Moines to Johannesburg OR Tambo should not be difficult; the airport handles an average of 0 outbound flights to Johannesburg OR Tambo per day.

  • How long is the flight from Des Moines to Johannesburg OR Tambo Airport?

    For as low as $1,236, American Airlines can have you in Johannesburg OR Tambo Airport from Des Moines in 32h 59m. Airlines will cover a distance of 8998 mi.

  • What are the cheapest airlines flying from Des Moines to Johannesburg OR Tambo Airport round-trip?

    Cheapflights users have booked flights from Des Moines to Johannesburg OR Tambo Airport round-trip from $1,322. Another airline that can offer you cheap pricing is Delta. You may be able to fly from Des Moines to Johannesburg OR Tambo Airport for 21% less than the average price by searching for these airlines.

  • What are the cheapest airlines to fly from Des Moines to Johannesburg OR Tambo Airport one-way?

    The cheapest airlines for a one-way flight from Des Moines to Johannesburg OR Tambo Airport are United Airlines ($1,273), Virgin Atlantic ($1,273), and KLM ($1,281).

  • Can I find deals for flights from Des Moines to OR Tambo that include hotel bookings?

    Yes. In addition to deals on Des Moines to OR Tambo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to OR Tambo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to OR Tambo.

  • Can I find deals for business class flights from Des Moines to OR Tambo?

    Yes. Cheapflights offers flight deals from Des Moines to OR Tambo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Johannesburg OR Tambo Airport?

    Currently, January is the cheapest month in which you can book a flight from Des Moines to Johannesburg OR Tambo Airport (average of $1,219). Flying from Des Moines to Johannesburg OR Tambo Airport in October is currently the most expensive (average of $1,882). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Johannesburg OR Tambo Airport?

Book flights to Johannesburg OR Tambo Airport if you plan to visit one of these locations
Sandton
Kempton Park
Edenvale

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Alternative routes for Des Moines to OR Tambo

See prices for flight routes from nearby airports that may be better suited for you.
Moline to OR Tambo flights
Omaha to OR Tambo flights

Top 2 airlines flying from Des Moines to OR Tambo

Discover the top 2 airlines that operate flights from Des Moines to OR Tambo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$1,322Average$1,503FlexibilityNo cancel feeOn-time69%
DeltaCheapest$1,410Average$1,973FlexibilityNo cancel feeOn-timeN/A

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