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$752+ Cheap flights from Santiago (SCL) to Missouri

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/11. Fares are subject to change and may not be available on all flights or dates of travel.
SCL — STL
Oct 29 — Nov 51
Wed 10/29
Wed 11/5
1 adult, Economy
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Cheap flight deals from Santiago to Missouri

Keep the following information in mind while searching for Santiago to Missouri flight deals. Data was last updated September 29, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$752
(United Airlines)

Popular in

March

Cheapest in

August

Average price

$1,019
Provider with most accurate pricing for Santiago Arturo Merino Benitez-Lambert-St Louis flight deals.
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Provider most trusted by Cheapflights users for Santiago Arturo Merino Benitez-Lambert-St Louis flights.
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From Santiago Arturo Merino Benitez to Missouri
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Highest demand for flights based on searches. 5% potential increase in price ($60 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($25 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Santiago to Missouri

Cheapest flights from Santiago to Missouri
Explore the most affordable flight options available from Santiago to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 29, 2025.

This United Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1110:45 pmSCL - STL
2 stops21h 54mUnited Airlines
Tue 11/184:35 pmSTL - SCL
1 stop13h 15mUnited Airlines
Deal found 9/27$752
This Delta deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1012:55 amSCL - STL
2 stops20h 40mDelta
Tue 11/1811:39 amSTL - SCL
2 stops16h 21mDelta
Deal found 9/27$755
This LATAM Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/114:35 amSCL - STL
2 stops20h 23mLATAM Airlines
Wed 11/191:55 pmSTL - SCL
1 stop14h 45mLATAM Airlines
Deal found 9/28$761
This Delta deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1311:40 pmSCL - STL
1 stop19h 53mDelta
Mon 11/171:55 pmSTL - SCL
1 stop14h 45mDelta
Deal found 9/28$764
This American Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/2210:25 pmSCL - STL
1 stop27h 10mAmerican Airlines
Thu 1/2211:06 amSTL - SCL
2 stops18h 59mAmerican Airlines
Deal found 9/27$765
This eDestinos deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/291:30 amSCL - STL
2 stops43h 30mMultiple Airlines
Sun 11/22:12 pmSTL - SCL
3 stops37h 48mMultiple Airlines
Deal found 9/29$777
This LATAM Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2912:20 amSCL - STL
2 stops19h 42mLATAM Airlines
Sun 11/21:30 pmSTL - SCL
2 stops13h 30mLATAM Airlines
Deal found 9/29$787
This Delta deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2410:50 pmSCL - STL
1 stop19h 53mDelta
Thu 10/3011:21 amSTL - SCL
2 stops17h 39mDelta
Deal found 9/28$791
This Delta deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2912:20 amSCL - STL
2 stops23h 08mDelta
Sun 11/21:30 pmSTL - SCL
1 stop15h 10mDelta
Deal found 9/29$795
This LATAM Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2312:10 amSCL - STL
2 stops25h 31mLATAM Airlines
Thu 10/307:05 amSTL - SCL
2 stops21h 30mLATAM Airlines
Deal found 9/28$800
This LATAM Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1312:20 amSCL - STL
2 stops20h 37mLATAM Airlines
Sun 11/166:00 amSTL - SCL
2 stops21h 00mLATAM Airlines
Deal found 9/28$827

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santiago to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 29, 2025.
Use the filters below to find and compare flights from Santiago to Missouri that are best for you.

Fly from

Santiago

Fly to

Missouri

Route

Depart

Return

Price

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Tue 11/11

10:45 pm-10:22 pm

1 stop26h 37m

Lambert-St Louis

Tue 11/18

4:35 pm-8:50 am

1 stop13h 15m

$752

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Thu 10/30

9:45 pm-2:25 pm

2 stops18h 40m

Lambert-St Louis

Sun 11/2

6:43 pm-8:50 am

2 stops35h 07m

$752

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Wed 11/12

10:45 pm-2:24 pm

2 stops18h 39m

Lambert-St Louis

Wed 11/19

4:35 pm-8:50 am

1 stop13h 15m

$752

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Thu 11/13

10:45 pm-10:39 am

1 stop14h 54m

Lambert-St Louis

Thu 11/20

6:15 am-8:50 am

1 stop23h 35m

$752

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Mon 12/22

11:10 pm-11:42 pm

1 stop27h 32m

Lambert-St Louis

Thu 1/22

6:00 am-5:35 am

2 stops20h 35m

$755

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Mon 11/10

12:55 am-6:35 pm

2 stops20h 40m

Lambert-St Louis

Tue 11/18

11:39 am-7:00 am

2 stops16h 21m

$755

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/27

Best time to book a flight from Santiago to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Santiago with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santiago to Missouri

What is the cheapest month to book a flight from Santiago to Missouri?

Currently, August is the cheapest month in which you can book a flight from Santiago to Missouri (average of $311). Flying from Santiago to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated September 29, 2025.
Get a feel of what it's like to fly with Delta and American Airlines from Santiago to Missouri by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,964 reviews

Overall

8.0

Comfort

7.9

Crew

8.5

Entertainment

7.9

Food

7.3

Boarding

8.2

Reviews

1 / 20
6.0
Good

Morgan Rae,Aug 2025

BRU - JFK

Typically I choose delta because they do a great job but this time the flight attendant in my zone was very rude and didnt offer the same treatment as she did to others
Delta
8.0
Very good
7,964 reviews
Delta
8.0
Very good
7,964 reviews

Overall

8.0

Comfort

7.9

Crew

8.5

Entertainment

7.9

Food

7.3

Boarding

8.2

Reviews

1 / 20
6.0
Good

Morgan Rae,Aug 2025

BRU - JFK

Typically I choose delta because they do a great job but this time the flight attendant in my zone was very rude and didnt offer the same treatment as she did to others
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,964 reviews

Overall

8.0

Comfort

7.9

Crew

8.5

Entertainment

7.9

Food

7.3

Boarding

8.2

Reviews

1 / 20
6.0
Good

Morgan Rae,Aug 2025

BRU - JFK

Typically I choose delta because they do a great job but this time the flight attendant in my zone was very rude and didnt offer the same treatment as she did to others

Related info for your journey

Find useful and relevant information for your journey from Santiago to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Santiago to Missouri?

    Santiago Arturo Merino Benitez (SCL) is the airport you will fly out of if you book a flight from Santiago to Missouri. It is only a 8.4 mi journey to Arturo Merino Benitez (SCL) from Santiago’s city center.

  • How long is the flight from Santiago to Missouri?

    Airlines like United Airlines fly from Santiago to Missouri in about 26h 37m. The time it takes to get you to your destination can typically vary by up to . Santiago and Missouri are separated by a distance of 5137 mi.

  • Can I find deals for flights from Santiago to Missouri that include hotel bookings?

    Yes. In addition to deals on Santiago to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santiago to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santiago to Missouri.

  • Can I find deals for business class flights from Santiago to Missouri?

    Yes. Cheapflights offers flight deals from Santiago to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santiago to Missouri?

    Currently, August is the cheapest month in which you can book a flight from Santiago to Missouri (average of $311). Flying from Santiago to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Santiago to Missouri

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Santiago to Missouri

Discover the top 2 airlines that operate flights from Santiago to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$782Average$1,076FlexibilityNo cancel feeOn-time71%
DeltaCheapest$843Average$1,065FlexibilityNo cancel feeOn-timeN/A

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