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$149+ Cheap flights from Portland, ME (PWM) to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/4. Fares are subject to change and may not be available on all flights or dates of travel.
PWM — STL
Aug 4 — Aug 111
Mon 8/4
Mon 8/11
1 adult, Economy
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Cheap flight deals from Portland to Missouri

Keep the following information in mind while searching for Portland to Missouri flight deals. Data was last updated July 30, 2025.

Round-trip from

$297
(United Airlines)

One-way from

$149
(American Airlines)

Popular in

April

Cheapest in

August

Average price

$402
From Portland to Missouri
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One-way flight from Portland to Missouri
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Highest demand for flights based on searches. 16% potential increase in price ($88 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($23 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from Portland to Missouri

Cheapest flights from Portland to Missouri
Explore the most affordable flight options available from Portland to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 30, 2025.

This United Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/244:56 pmPWM - STL
1 stop6h 39mUnited Airlines
Sat 9/273:23 pmSTL - PWM
1 stop5h 21mUnited Airlines
Deal found 7/30$297
This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/294:05 pmPWM - MCI
1 stop6h 53mAmerican Airlines
Fri 9/55:40 pmMCI - PWM
1 stop5h 05mAmerican Airlines
Deal found 7/30$297
This Delta deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/246:00 amPWM - STL
2 stops11h 05mDelta
Sat 9/2710:40 amSTL - PWM
2 stops10h 20mDelta
Deal found 7/30$307
This Southwest deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/155:40 amPWM - MCI
1 stop6h 10mSouthwest
Thu 11/206:00 amMCI - PWM
1 stop5h 10mSouthwest
Deal found 7/29$312
This Mytrip deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/96:58 pmPWM - STL
1 stop29h 49mFrontier
Fri 8/155:40 pmSTL - PWM
1 stop23h 33mFrontier
Deal found 7/28$337
This Southwest deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/235:45 amPWM - STL
2 stops8h 15mSouthwest
Tue 8/261:35 pmSTL - PWM
2 stops7h 50mSouthwest
Deal found 7/30$382
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/209:08 amPWM - SGF
1 stop7h 40mAmerican Airlines
Sun 8/243:45 pmSGF - PWM
1 stop7h 14mAmerican Airlines
Deal found 7/29$389
This United Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/134:56 pmPWM - MCI
1 stop7h 18mUnited Airlines
Tue 8/197:30 amMCI - PWM
1 stop5h 56mUnited Airlines
Deal found 7/29$402
This American Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/146:00 amPWM - STL
1 stop4h 40mAmerican Airlines
Sun 8/175:27 amSTL - PWM
1 stop7h 24mAmerican Airlines
Deal found 7/28$447
This Delta deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/255:40 amPWM - MCI
1 stop9h 14mDelta
Fri 11/286:00 amMCI - PWM
1 stop4h 51mDelta
Deal found 7/29$447
This United Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/166:14 amPWM - SGF
1 stop5h 36mUnited Airlines
Fri 9/196:20 pmSGF - PWM
1 stop19h 06mUnited Airlines
Deal found 7/28$462
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/161:40 pmPWM - SGF
2 stops9h 22mDelta
Fri 9/194:13 pmSGF - PWM
1 stop6h 58mDelta
Deal found 7/28$473

Cheapflights Fare Finder

 
Customize your flight search to find flights from Portland to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 30, 2025.
Use the filters below to find and compare flights from Portland to Missouri that are best for you.

Fly from

Portland

Fly to

Missouri

Route

Depart

Return

Price

PortlandSt. Louis

PWM - STL

PWMSTL

Portland

Wed 9/24

4:56 pm-10:35 pm

1 stop6h 39m

Lambert-St Louis

Sat 9/27

3:23 pm-9:44 pm

1 stop5h 21m

$297

PortlandKansas City

PWM - MCI

PWMMCI

Portland

Fri 8/29

4:05 pm-9:58 pm

1 stop6h 53m

Kansas City

Fri 9/5

5:40 pm-11:45 pm

1 stop5h 05m

$297

PortlandSt. Louis

PWM - STL

PWMSTL

Portland

Wed 9/24

6:00 am-4:05 pm

2 stops11h 05m

Lambert-St Louis

Sat 9/27

10:40 am-10:00 pm

2 stops10h 20m

$307

PortlandKansas City

PWM - MCI

PWMMCI

Portland

Sat 11/15

5:40 am-10:50 am

1 stop6h 10m

Kansas City

Thu 11/20

6:00 am-12:10 pm

1 stop5h 10m

$312

PortlandSt. Louis

PWM - STL

PWMSTL

Portland

Sat 8/9

6:58 pm-11:47 pm

1 stop29h 49m

Lambert-St Louis

Fri 8/15

5:40 pm-6:13 pm

1 stop23h 33m

$337

PortlandSt. Louis

PWM - STL

PWMSTL

Portland

Sat 8/23

5:45 am-1:00 pm

2 stops8h 15m

Lambert-St Louis

Tue 8/26

1:35 pm-10:25 pm

2 stops7h 50m

$382

PortlandSpringfield

PWM - SGF

PWMSGF

Portland

Wed 8/20

9:08 am-3:48 pm

1 stop7h 40m

Springfield-Branson

Sun 8/24

3:45 pm-11:59 pm

1 stop7h 14m

$389

PortlandKansas City

PWM - MCI

PWMMCI

Portland

Wed 8/13

4:56 pm-11:14 pm

1 stop7h 18m

Kansas City

Tue 8/19

7:30 am-2:26 pm

1 stop5h 56m

$402

PortlandKansas City

PWM - MCI

PWMMCI

Portland

Tue 11/25

5:40 am-1:54 pm

1 stop9h 14m

Kansas City

Fri 11/28

6:00 am-11:51 am

1 stop4h 51m

$447

PortlandSt. Louis

PWM - STL

PWMSTL

Portland

Thu 8/14

6:00 am-9:40 am

1 stop4h 40m

Lambert-St Louis

Sun 8/17

5:27 am-1:51 pm

1 stop7h 24m

$447

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/29

Showing 1-10 of 25 results
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2
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Best time to book a flight from Portland to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Portland with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Portland to Missouri

What is the cheapest month to book a flight from Portland, Maine to Missouri?

Currently, August is the cheapest month in which you can book a flight from Portland, Maine to Missouri (average of $311). Flying from Portland, Maine to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PWM to MO?

Find hourly flight availability from Portland to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 30, 2025.

When flying from Portland, Maine to Missouri, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

How much does it cost to fly round-trip from Portland, Maine to Missouri?

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated July 30, 2025.
See what other customers who have flown with Southwest, Delta, and United Airlines from Portland to Missouri have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,241 reviews

Boarding

8.1

Crew

8.6

Food

7.0

Overall

8.0

Comfort

8.0

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Southwest
8.0
Very good
4,241 reviews
Southwest
8.0
Very good
4,241 reviews

Boarding

8.1

Crew

8.6

Food

7.0

Overall

8.0

Comfort

8.0

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Delta
8.0
Very good
7,980 reviews
Southwest
8.0
Very good
4,241 reviews

Boarding

8.1

Crew

8.6

Food

7.0

Overall

8.0

Comfort

8.0

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
United Airlines
7.4
Good
8,896 reviews
Southwest
8.0
Very good
4,241 reviews

Boarding

8.1

Crew

8.6

Food

7.0

Overall

8.0

Comfort

8.0

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,241 reviews

Boarding

8.1

Crew

8.6

Food

7.0

Overall

8.0

Comfort

8.0

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Frontier
5.9
Fair
3,237 reviews
Southwest
8.0
Very good
4,241 reviews

Boarding

8.1

Crew

8.6

Food

7.0

Overall

8.0

Comfort

8.0

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.

Related info for your journey

Find useful and relevant information for your journey from Portland to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Portland to Missouri?

    Located just 2.9 mi from the city center, Portland (PWM) is the airport most travelers will use when flying to Missouri from Portland.

  • What are the cheapest airlines to fly from Portland, Maine to Missouri one-way?

    One-way options have recently been found by users for as low as $149 on American Airlines. Other airlines that offer cheap prices include Delta from $154 and United Airlines from $166 one-way.

  • What are the most popular routes from Portland, Maine to Missouri?

    When deciding which route to take from Portland, Maine to Missouri consider Portland - Kansas City, Portland - Springfield-Branson or Portland - Lambert-St Louis as they are the most popular.

  • Can I find deals for flights from Portland to Missouri that include hotel bookings?

    Yes. In addition to deals on Portland to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Portland to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Portland to Missouri.

  • Can I find deals for business class flights from Portland to Missouri?

    Yes. Cheapflights offers flight deals from Portland to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Portland, Maine to Missouri?

    Currently, August is the cheapest month in which you can book a flight from Portland, Maine to Missouri (average of $311). Flying from Portland, Maine to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Portland to Missouri

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Portland to Missouri

Discover the top 4 airlines that operate flights from Portland to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$236Average$395FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$237Average$482FlexibilityNo cancel feeOn-time63%
American AirlinesCheapest$243Average$445FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$268Average$549FlexibilityNo cancel feeOn-time69%

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