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$180+ Cheap flights from Portland, ME (PWM) to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/12. Fares are subject to change and may not be available on all flights or dates of travel.
PWM — STL
Nov 28 — Dec 51
Fri 11/28
Fri 12/5
1 adult, Economy
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Cheap flight deals from Portland to Missouri

Keep the following information in mind while searching for Portland to Missouri flight deals. Data was last updated October 29, 2025.

Most accurate provider

Gotogate
3 stars

Most trusted provider

Gotogate
3 stars

Round-trip from

$281
(Kiwi.com)

One-way from

$180
(Kiwi.com)

Popular in

December

Cheapest in

February

Average price

$364
Provider with most accurate pricing for Portland-Lambert-St Louis flight deals.
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Provider most trusted by Cheapflights users for Portland-Lambert-St Louis flights.
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From Portland to Missouri
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One-way flight from Portland to Missouri
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Highest demand for flights based on searches. 12% potential increase in price ($55 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($14 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Portland to Missouri

Cheapest flights from Portland to Missouri
Explore the most affordable flight options available from Portland to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 29, 2025.

This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1911:21 amPWM - MCI
2 stops25h 42mMultiple Airlines
Thu 12/43:47 pmMCI - PWM
1 stop16h 19mMultiple Airlines
Deal found 10/27$281
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/85:17 pmPWM - STL
1 stop5h 30mAmerican Airlines
Thu 12/119:53 amSTL - PWM
1 stop5h 35mAmerican Airlines
Deal found 10/27$299
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/36:18 pmPWM - MCI
1 stop22h 27mMultiple Airlines
Sun 12/73:47 pmMCI - PWM
1 stop16h 19mMultiple Airlines
Deal found 10/27$306
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/33:55 pmPWM - MCI
1 stop6h 56mAmerican Airlines
Mon 12/86:00 amMCI - PWM
1 stop4h 37mAmerican Airlines
Deal found 10/27$313
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/114:57 pmPWM - SGF
1 stop6h 16mUnited Airlines
Sat 11/153:20 pmSGF - PWM
1 stop5h 30mUnited Airlines
Deal found 10/27$319
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/35:34 amPWM - MCI
2 stops9h 16mAmerican Airlines
Sun 12/76:00 amMCI - PWM
1 stop4h 37mAmerican Airlines
Deal found 10/27$320
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/116:00 amPWM - SGF
2 stops12h 30mAmerican Airlines
Sat 11/154:28 pmSGF - PWM
1 stop5h 04mAmerican Airlines
Deal found 10/27$324
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/89:46 amPWM - STL
1 stop13h 47mMultiple Airlines
Thu 12/1112:04 pmSTL - PWM
2 stops21h 37mMultiple Airlines
Deal found 10/27$333
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/23:52 pmPWM - MCI
1 stop8h 20mAmerican Airlines
Sun 12/76:00 amMCI - PWM
1 stop5h 11mAmerican Airlines
Deal found 10/27$337
This Southwest deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/93:30 pmPWM - STL
1 stop7h 30mSouthwest
Thu 12/117:00 amSTL - PWM
2 stops6h 55mSouthwest
Deal found 10/27$344
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/126:00 amPWM - SGF
2 stops13h 15mDelta
Mon 11/174:02 pmSGF - PWM
1 stop5h 17mDelta
Deal found 10/28$344
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/216:00 amPWM - STL
1 stop8h 00mDelta
Mon 11/242:00 pmSTL - PWM
1 stop7h 19mDelta
Deal found 10/27$349

Cheapflights Fare Finder

 
Customize your flight search to find flights from Portland to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 29, 2025.
Use the filters below to find and compare flights from Portland to Missouri that are best for you.

Fly from

Portland

Fly to

Missouri

Route

Depart

Return

Price

PortlandKansas City

PWM - MCI

PWMMCI

Portland

Wed 11/19

11:21 am-12:03 pm

2 stops25h 42m

Kansas City

Thu 12/4

3:47 pm-9:06 am

1 stop16h 19m

$281

PortlandSt. Louis

PWM - STL

PWMSTL

Portland

Tue 12/9

7:00 am-1:18 pm

1 stop7h 18m

Lambert-St Louis

Thu 12/11

9:53 am-4:28 pm

1 stop5h 35m

$299

PortlandSt. Louis

PWM - STL

PWMSTL

Portland

Mon 12/8

5:17 pm-9:47 pm

1 stop5h 30m

Lambert-St Louis

Thu 12/11

9:53 am-4:28 pm

1 stop5h 35m

$299

PortlandKansas City

PWM - MCI

PWMMCI

Portland

Tue 3/3

11:25 am-4:12 pm

1 stop5h 47m

Kansas City

Wed 3/4

6:00 am-11:57 am

1 stop4h 57m

$313

PortlandKansas City

PWM - MCI

PWMMCI

Portland

Wed 12/3

3:55 pm-9:51 pm

1 stop6h 56m

Kansas City

Mon 12/8

6:00 am-11:37 am

1 stop4h 37m

$313

PortlandSpringfield

PWM - SGF

PWMSGF

Portland

Tue 11/11

4:57 pm-10:13 pm

1 stop6h 16m

Springfield-Branson

Sat 11/15

3:20 pm-9:50 pm

1 stop5h 30m

$319

PortlandSpringfield

PWM - SGF

PWMSGF

Portland

Wed 11/12

7:02 am-12:20 pm

1 stop6h 18m

Springfield-Branson

Mon 11/17

1:25 pm-9:35 pm

1 stop7h 10m

$319

PortlandSpringfield

PWM - SGF

PWMSGF

Portland

Thu 11/13

10:45 am-10:13 pm

2 stops12h 28m

Springfield-Branson

Wed 11/19

8:00 am-2:12 pm

1 stop5h 12m

$324

PortlandKansas City

PWM - MCI

PWMMCI

Portland

Wed 12/3

5:34 am-1:50 pm

2 stops9h 16m

Kansas City

Sun 12/7

5:13 am-3:27 pm

2 stops9h 14m

$325

PortlandKansas City

PWM - MCI

PWMMCI

Portland

Tue 12/2

3:52 pm-11:12 pm

1 stop8h 20m

Kansas City

Sun 12/7

6:00 am-12:11 pm

1 stop5h 11m

$337

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/27

Showing 1-10 of 40 results
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Best time to book a flight from Portland to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Portland with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Portland to Missouri

What is the cheapest month to book a flight from Portland, Maine to Missouri?

Currently, December is the cheapest month in which you can book a flight from Portland, Maine to Missouri (average of $107). Flying from Portland, Maine to Missouri in June is currently the most expensive (average of $287). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PWM to MO?

Find hourly flight availability from Portland to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 29, 2025.

When flying from Portland, Maine to Missouri, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 40% versus a flight in the morning.

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated October 29, 2025.
See what other customers who have flown with Southwest, Delta, and United Airlines from Portland to Missouri have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,241 reviews

Boarding

8.1

Crew

8.6

Comfort

8.0

Entertainment

7.5

Overall

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,241 reviews
Southwest
8.0
Very good
4,241 reviews

Boarding

8.1

Crew

8.6

Comfort

8.0

Entertainment

7.5

Overall

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Delta
7.9
Good
7,992 reviews
Southwest
8.0
Very good
4,241 reviews

Boarding

8.1

Crew

8.6

Comfort

8.0

Entertainment

7.5

Overall

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
United Airlines
7.4
Good
8,999 reviews
Southwest
8.0
Very good
4,241 reviews

Boarding

8.1

Crew

8.6

Comfort

8.0

Entertainment

7.5

Overall

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
11,032 reviews
Southwest
8.0
Very good
4,241 reviews

Boarding

8.1

Crew

8.6

Comfort

8.0

Entertainment

7.5

Overall

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Portland to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Portland to Missouri?

    Located just 2.9 mi from the city center, Portland (PWM) is the airport most travelers will use when flying to Missouri from Portland.

  • How long is the flight from Portland, Maine to Missouri?

    There are many flights that can get you from Portland, Maine to Missouri in 5h 47m. Fly via American Airlines, Delta, or United Airlines to get the fastest option. Portland, Maine and Missouri are separated by a distance of 1293 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Portland, Maine to Missouri one-way?

    One-way options have recently been found by users for as low as $214 on American Airlines. Other airlines that offer cheap prices include United Airlines from $214 and Delta from $214 one-way.

  • What are the most popular routes from Portland, Maine to Missouri?

    When deciding which route to take from Portland, Maine to Missouri consider Portland - Kansas City, Portland - Lambert-St Louis or Portland - Springfield-Branson as they are the most popular.

  • Can I find deals for flights from Portland to Missouri that include hotel bookings?

    Yes. In addition to deals on Portland to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Portland to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Portland to Missouri.

  • Can I find deals for business class flights from Portland to Missouri?

    Yes. Cheapflights offers flight deals from Portland to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Portland, Maine to Missouri?

    Currently, December is the cheapest month in which you can book a flight from Portland, Maine to Missouri (average of $107). Flying from Portland, Maine to Missouri in June is currently the most expensive (average of $287). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Portland to Missouri

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Portland to Missouri

Discover the top 4 airlines that operate flights from Portland to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$173Average$400FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$237Average$490FlexibilityNo cancel feeOn-time63%
American AirlinesCheapest$243Average$463FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$268Average$648FlexibilityNo cancel feeOn-time69%

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