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$102+ Cheap flights from Portland, ME (PWM) to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/28. Fares are subject to change and may not be available on all flights or dates of travel.
PWM — STL
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheap flight deals from Portland to Missouri

Keep the following information in mind while searching for Portland to Missouri flight deals. Data was last updated September 11, 2025.

Round-trip from

$229
(United Airlines)

One-way from

$102
(Southwest)

Popular in

April

Cheapest in

September

Average price

$316
From Portland to Missouri
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One-way flight from Portland to Missouri
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Highest demand for flights based on searches. 17% potential increase in price ($94 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($24 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Portland to Missouri

Cheapest flights from Portland to Missouri
Explore the most affordable flight options available from Portland to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/306:00 amPWM - STL
1 stop5h 48mUnited Airlines
Tue 9/303:23 pmSTL - PWM
1 stop5h 21mUnited Airlines
Deal found 9/11$229
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/305:20 pmPWM - MCI
1 stop5h 50mAmerican Airlines
Wed 10/84:54 pmMCI - PWM
1 stop5h 57mAmerican Airlines
Deal found 9/10$239
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/85:42 amPWM - STL
2 stops11h 13mDelta
Wed 10/156:40 amSTL - PWM
1 stop4h 20mDelta
Deal found 9/10$242
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/165:59 pmPWM - STL
1 stop6h 59mAmerican Airlines
Sat 10/186:00 amSTL - PWM
1 stop5h 42mAmerican Airlines
Deal found 9/10$243
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/306:14 amPWM - MCI
1 stop5h 23mUnited Airlines
Tue 10/71:00 pmMCI - PWM
2 stops9h 13mUnited Airlines
Deal found 9/10$244
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/31:35 pmPWM - STL
1 stop5h 12mDelta
Mon 10/61:30 pmSTL - PWM
1 stop7h 49mDelta
Deal found 9/10$272
This Delta deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/291:27 pmPWM - STL
1 stop5h 35mDelta
Sun 11/25:00 amSTL - PWM
1 stop5h 32mDelta
Deal found 9/11$277
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/243:28 pmPWM - MCI
1 stop7h 45mAmerican Airlines
Sat 11/16:00 amMCI - PWM
1 stop7h 10mAmerican Airlines
Deal found 9/10$278
This Delta deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/311:46 pmPWM - MCI
1 stop5h 18mDelta
Sat 11/16:15 amMCI - PWM
1 stop4h 45mDelta
Deal found 9/11$287
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/304:57 pmPWM - MCI
1 stop5h 48mUnited Airlines
Wed 10/810:01 amMCI - PWM
2 stops8h 40mUnited Airlines
Deal found 9/10$294
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/105:21 pmPWM - MCI
1 stop6h 44mAmerican Airlines
Sat 11/156:00 amMCI - PWM
1 stop5h 08mAmerican Airlines
Deal found 9/10$295
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/86:00 amPWM - STL
1 stop5h 17mAmerican Airlines
Fri 12/122:04 pmSTL - PWM
1 stop6h 33mAmerican Airlines
Deal found 9/9$317

Cheapflights Fare Finder

 
Customize your flight search to find flights from Portland to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Portland to Missouri that are best for you.

Fly from

Portland

Fly to

Missouri

Route

Depart

Return

Price

PortlandSt. Louis

PWM - STL

PWMSTL

Portland

Tue 9/30

6:00 am-12:51 pm

1 stop7h 51m

Lambert-St Louis

Tue 9/30

6:00 pm-11:45 pm

1 stop4h 45m

$229

PortlandSt. Louis

PWM - STL

PWMSTL

Portland

Tue 9/30

6:14 am-10:49 am

1 stop5h 35m

Lambert-St Louis

Tue 9/30

3:23 pm-11:59 pm

2 stops7h 36m

$234

PortlandSt. Louis

PWM - STL

PWMSTL

Portland

Wed 10/8

5:42 am-3:55 pm

2 stops11h 13m

Lambert-St Louis

Wed 10/15

6:40 am-12:00 pm

1 stop4h 20m

$242

PortlandKansas City

PWM - MCI

PWMMCI

Portland

Tue 9/30

6:14 am-10:37 am

1 stop5h 23m

Kansas City

Tue 10/7

1:00 pm-11:13 pm

2 stops9h 13m

$244

PortlandKansas City

PWM - MCI

PWMMCI

Portland

Tue 3/3

12:50 pm-5:22 pm

1 stop5h 32m

Kansas City

Wed 3/4

2:55 pm-9:59 pm

1 stop6h 04m

$257

PortlandSt. Louis

PWM - STL

PWMSTL

Portland

Fri 10/3

5:10 pm-11:07 pm

1 stop6h 57m

Lambert-St Louis

Mon 10/6

4:34 pm-10:45 pm

1 stop5h 11m

$272

PortlandSt. Louis

PWM - STL

PWMSTL

Portland

Fri 10/3

1:35 pm-5:47 pm

1 stop5h 12m

Lambert-St Louis

Mon 10/6

1:30 pm-10:19 pm

1 stop7h 49m

$272

PortlandSt. Louis

PWM - STL

PWMSTL

Portland

Mon 12/8

6:00 am-10:17 am

1 stop5h 17m

Lambert-St Louis

Fri 12/12

2:04 pm-9:37 pm

1 stop6h 33m

$272

PortlandSt. Louis

PWM - STL

PWMSTL

Portland

Wed 10/29

11:30 am-3:29 pm

1 stop4h 59m

Lambert-St Louis

Sun 11/2

4:10 pm-12:05 am

1 stop6h 55m

$277

PortlandKansas City

PWM - MCI

PWMMCI

Portland

Fri 10/24

3:28 pm-10:13 pm

1 stop7h 45m

Kansas City

Sat 11/1

6:00 am-2:10 pm

1 stop7h 10m

$278

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Showing 1-10 of 36 results
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Best time to book a flight from Portland to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Portland with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Portland to Missouri

What is the cheapest month to book a flight from Portland, Maine to Missouri?

Currently, August is the cheapest month in which you can book a flight from Portland, Maine to Missouri (average of $311). Flying from Portland, Maine to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PWM to MO?

Find hourly flight availability from Portland to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 11, 2025.

When flying from Portland, Maine to Missouri, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

How much does it cost to fly round-trip from Portland, Maine to Missouri?

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated September 11, 2025.
See what other customers who have flown with Southwest, Delta, and United Airlines from Portland to Missouri have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,248 reviews

Overall

8.0

Comfort

8.0

Boarding

8.1

Crew

8.6

Food

7.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,248 reviews
Southwest
8.0
Very good
4,248 reviews

Overall

8.0

Comfort

8.0

Boarding

8.1

Crew

8.6

Food

7.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Delta
8.0
Very good
7,960 reviews
Southwest
8.0
Very good
4,248 reviews

Overall

8.0

Comfort

8.0

Boarding

8.1

Crew

8.6

Food

7.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
United Airlines
7.4
Good
8,937 reviews
Southwest
8.0
Very good
4,248 reviews

Overall

8.0

Comfort

8.0

Boarding

8.1

Crew

8.6

Food

7.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,248 reviews

Overall

8.0

Comfort

8.0

Boarding

8.1

Crew

8.6

Food

7.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Portland to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Portland to Missouri?

    Located just 2.9 mi from the city center, Portland (PWM) is the airport most travelers will use when flying to Missouri from Portland.

  • How long is the flight from Portland, Maine to Missouri?

    There are many flights that can get you from Portland, Maine to Missouri in 5h 35m. Fly via American Airlines, United Airlines, or Delta to get the fastest option. Portland, Maine and Missouri are separated by a distance of 1092 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Portland, Maine to Missouri one-way?

    One-way options have recently been found by users for as low as $102 on Southwest. Other airlines that offer cheap prices include American Airlines from $129 and Delta from $189 one-way.

  • What are the most popular routes from Portland, Maine to Missouri?

    When deciding which route to take from Portland, Maine to Missouri consider Portland - Lambert-St Louis, Portland - Kansas City or Portland - Springfield-Branson as they are the most popular.

  • Can I find deals for flights from Portland to Missouri that include hotel bookings?

    Yes. In addition to deals on Portland to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Portland to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Portland to Missouri.

  • Can I find deals for business class flights from Portland to Missouri?

    Yes. Cheapflights offers flight deals from Portland to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Portland, Maine to Missouri?

    Currently, August is the cheapest month in which you can book a flight from Portland, Maine to Missouri (average of $311). Flying from Portland, Maine to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Portland to Missouri

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Top 4 airlines flying from Portland to Missouri

Discover the top 4 airlines that operate flights from Portland to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$173Average$399FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$237Average$482FlexibilityNo cancel feeOn-time63%
American AirlinesCheapest$243Average$452FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$268Average$549FlexibilityNo cancel feeOn-time69%

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